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https://www.readbyqxmd.com/read/29031215/comprehensive-multipathway-risk-assessment-of-chemicals-associated-with-recycled-crumb-rubber-in-synthetic-turf-fields
#1
Michael K Peterson, Julie C Lemay, Sara Pacheco Shubin, Robyn L Prueitt
BACKGROUND: Thousands of synthetic turf fields in the US are regularly used by millions of individuals (particularly children and adolescents). Although many safety assessments have concluded that there are low or negligible risks related to exposure to chemicals found in the recycled rubber used to make these fields, concerns remain about the safety of this product. Existing studies of recycled rubber's potential health risks have limitations such as small sample sizes and limited evaluation of relevant exposure pathways and scenarios...
October 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/29031119/index-analysis-and-human-health-risk-model-application-for-evaluating-ambient-air-heavy-metal-contamination-in-chemical-valley-sarnia
#2
Richard Olawoyin, Linda Schweitzer, Kuangyuan Zhang, Oladapo Okareh, Kevin Slates
The impacts of air emissions as a consequence of industrial activities around communities of human habitation have been extensively reported. This study is the first to assess potential adverse human health effects in the Chemical Valley Sarnia (CVS) area, around the St. Clair River, using health risk models, ecological and pollution indices. Large quantities of particulate matters (PM) are generated from anthropogenic activities, which contain several heavy metals in trace quantities with potentially adverse effects to humans and environmental health...
October 11, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29031041/concept-analysis-of-growth-failure-in-preterm-infants-in-the-nicu
#3
Lindsay K Schehr, Teresa S Johnson
Growth failure has not been consistently defined for preterm infants, which contributes to unclear clinical guidelines for optimal growth and development. Therefore, the purpose of this concept analysis was to identify all uses and attributes of the concept, present model and contrary cases, identify antecedents and consequences, define empirical referents, and provide an operational definition of growth failure among preterm infants in the NICU.
October 11, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29031037/-evaluation-of-anti-cancer-therapies-with-reimbursement-limited-to-comprehensive-cancer-centres-using-the-european-society-for-medical-oncology-magnitude-of-clinical-benefit-scale
#4
T Büchler, B Melichar, D Vrána, R Lemstrová, J Fínek, L Dušek, K Petráková, J Prausová
BACKGROUND: The costs of oncology treatments are increasing, due to the rising prevalence of malignant diseases and the introduction of expensive novel anti-cancer agents. The new European Society for Clinical Oncology (ESMO) has recently developed a new parametric system to evaluate the clinical benefit of drugs. The Magnitude of Clinical Benefit Scale (ESMO-MCBS) compares the contribution of a novel drug based on overall and progression-free survival and quality of life with those of current treatment options...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29029375/treatment-and-disease-management-of-multiple-sclerosis-patients-a-review-for-nurse-practitioners
#5
Cortnee Roman, Kara Menning
BACKGROUND AND PURPOSE: This review discusses the role of the nurse practitioner (NP) in evaluating the clinical effects, potential side effects, and monitoring requirements for treatment options in multiple sclerosis (MS) and provides guidance on how to help patients understand these issues. METHODS: A literature search was conducted on PubMed to identify publications on monitoring and disease management of MS patients. Additional resources included drug information web sites and package inserts...
October 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29029350/the-british-society-for-rheumatology-guideline-for-the-management-of-systemic-lupus-erythematosus-in-adults
#6
Caroline Gordon, Maame-Boatemaa Amissah-Arthur, Mary Gayed, Sue Brown, Ian N Bruce, David D'Cruz, Benjamin Empson, Bridget Griffiths, David Jayne, Munther Khamashta, Liz Lightstone, Peter Norton, Yvonne Norton, Karen Schreiber, David Isenberg
No abstract text is available yet for this article.
October 6, 2017: Rheumatology
https://www.readbyqxmd.com/read/29029325/guidelines-for-the-use-of-electrophysiological-monitoring-for-surgery-of-the-human-spinal-column-and-spinal-cord
#7
Mark N Hadley, Christopher D Shank, Curtis J Rozzelle, Beverly C Walters
No abstract text is available yet for this article.
September 27, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29029296/the-british-society-for-rheumatology-guideline-for-the-management-of-systemic-lupus-erythematosus-in-adults-executive-summary
#8
Caroline Gordon, Maame-Boatemaa Amissah-Arthur, Mary Gayed, Sue Brown, Ian N Bruce, David D'Cruz, Benjamin Empson, Bridget Griffiths, David Jayne, Munther Khamashta, Liz Lightstone, Peter Norton, Yvonne Norton, Karen Schreiber, David Isenberg
No abstract text is available yet for this article.
October 6, 2017: Rheumatology
https://www.readbyqxmd.com/read/29029294/cardiovascular-events-in-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-a-meta-analysis-of-observational-studies
#9
Eline Houben, Erik L Penne, Alexandre E Voskuyl, Joost W van der Heijden, René H J Otten, Maarten Boers, Tiny Hoekstra
Objectives: Several chronic inflammatory diseases are associated with cardiovascular disease, but the risk in ANCA-associated vasculitis is poorly quantified. The aim of the present study was to review the evidence for an increased cardiovascular risk, including ischaemic heart disease, cerebrovascular accidents and peripheral arterial disease, in patients with ANCA-associated vasculitis. Methods: A comprehensive systematic review was conducted in accordance with guidelines of preferred reporting items for systematic reviews and meta-analyses...
September 18, 2017: Rheumatology
https://www.readbyqxmd.com/read/29029272/bsr-and-bhpr-guideline-for-the-prescription-and-monitoring-of-non-biologic-disease-modifying-anti-rheumatic-drugs
#10
Jo Ledingham, Nicola Gullick, Katherine Irving, Rachel Gorodkin, Melissa Aris, Jean Burke, Patrick Gordon, Dimitrios Christidis, Sarah Galloway, Eranga Hayes, Andrew Jeffries, Scott Mercer, Janice Mooney, Sander van Leuven, James Galloway
No abstract text is available yet for this article.
September 28, 2017: Rheumatology
https://www.readbyqxmd.com/read/29029165/depicting-new-pharmacological-strategies-for-familial-hypercholesterolaemia-involving-lipoprotein-a
#11
Alpo Vuorio, Gerald F Watts, Petri T Kovanen
Approximately 35 million people worldwide suffer from heterozygous familial hypercholesterolaemia (HeFH), a condition characterized by genetically determined life-long elevation of plasma low-density lipoprotein cholesterol (LDL-C). One in three of these patients also inherit an elevated plasma concentration of lipoprotein (a) [Lp(a)], a lipoprotein particle with atherogenic, inflammatory and prothrombotic properties. Accordingly, the combination of high plasma LDL-C and Lp(a) can markedly accelerate premature atherosclerotic cardiovascular disease (ASCVD)...
October 3, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29029123/outcome-of-elevated-ca125-values-from-primary-care-following-implementation-of-ovarian-cancer-guidelines
#12
S Michael Crawford, Colin Evans
Background: Ovarian cancer presents later in the UK compared to economically similar countries. National guidance suggests measuring CA125 in primary care as a means of bringing patients to specialist attention. Aim: To investigate the outcome of CA125 values measured in accordance with this policy. Setting and design: Examination of the laboratory records of female patients from the usual catchment population of one general hospital in whom CA125 was measured from primary care in a calendar year...
September 28, 2017: Family Practice
https://www.readbyqxmd.com/read/29029110/2017-eacts-guidelines-on-perioperative-medication-in-adult-cardiac-surgery
#13
Miguel Sousa-Uva, Stuart J Head, Milan Milojevic, Jean-Philippe Collet, Giovanni Landoni, Manuel Castella, Joel Dunning, Tómas Gudbjartsson, Nick J Linker, Elena Sandoval, Matthias Thielmann, Anders Jeppsson, Ulf Landmesser
No abstract text is available yet for this article.
October 6, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29029100/2017-eacts-eacta-guidelines-on-patient-blood-management-for-adult-cardiac-surgery-the-task-force-on-patient-blood-management-for-adult-cardiac-surgery-of-the-european-association-for-cardio-thoracic-surgery-eacts-and-the-european-association-of-cardiothoracic
#14
Domenico Pagano, Milan Milojevic, Michael I Meesters, Umberto Benedetto, Daniel Bolliger, Christian von Heymann, Anders Jeppsson, Andreas Koster, Ruben L Osnabrugge, Marco Ranucci, Hanne Berg Ravn, Alexander B A Vonk, Alexander Wahba, Christa Boer, Moritz W V Wyler von Ballmoos, Mate Petricevic, Arie Pieter Kappetein, Miguel Sousa-Uva, Georg Trummer, Peter M Rosseel, Michael Sander, Pascal Colson, Adrian Bauer
No abstract text is available yet for this article.
October 3, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29029073/clinical-genetics-and-outcome-of-left-ventricular-non-compaction-cardiomyopathy
#15
Farbod Sedaghat-Hamedani, Jan Haas, Feng Zhu, Christian Geier, Elham Kayvanpour, Martin Liss, Alan Lai, Karen Frese, Regina Pribe-Wolferts, Ali Amr, Daniel Tian Li, Omid Shirvani Samani, Avisha Carstensen, Diana Martins Bordalo, Marion Müller, Christine Fischer, Jing Shao, Jing Wang, Ming Nie, Li Yuan, Sabine Haßfeld, Christine Schwartz, Min Zhou, Zihua Zhou, Yanwen Shu, Min Wang, Kai Huang, Qiutang Zeng, Longxian Cheng, Tobias Fehlmann, Philipp Ehlermann, Andreas Keller, Christoph Dieterich, Katrin Streckfuß-Bömeke, Yuhua Liao, Michael Gotthardt, Hugo A Katus, Benjamin Meder
Aims: In this study, we aimed to clinically and genetically characterize LVNC patients and investigate the prevalence of variants in known and novel LVNC disease genes. Introduction: Left ventricular non-compaction cardiomyopathy (LVNC) is an increasingly recognized cause of heart failure, arrhythmia, thromboembolism, and sudden cardiac death. We sought here to dissect its genetic causes, phenotypic presentation and outcome. Methods and results: In our registry with follow-up of in the median 61 months, we analysed 95 LVNC patients (68 unrelated index patients and 27 affected relatives; definite familial LVNC = 23...
October 6, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29029070/development-and-validation-of-an-lc-tandem-ms-assay-for-the-quantification-of-%C3%AE-lactam-antibiotics-in-the-sputum-of-cystic-fibrosis-patients
#16
Katrien Forier, Virginie Van Heck, Mieke Carlier, Eva Van Braeckel, Sabine Van Daele, Frans De Baets, Petra Schelstraete, Filomeen Haerynck, Veronique Stove, Leen Van Simaey, Mario Vaneechoutte, Alain G Verstraete
Objectives: Antibiotic therapy is of vital importance for the control of infectious exacerbations in cystic fibrosis (CF) patients. However, very little is known regarding the fraction of systemically administered antibiotics reaching the lower respiratory tract secretions. We developed and validated a method to measure the concentrations of piperacillin, ceftazidime, meropenem and aztreonam in CF sputum, and present the validation data. Methods: Ultra-performance LC coupled to tandem MS was used...
September 27, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29029068/considering-health-equity-when-moving-from-evidence-based-guideline-recommendations-to-implementation-a-case-study-from-an-upper-middle-income-country-on-the-grade-approach
#17
Javier Eslava-Schmalbach, Paola Mosquera, Juan Pablo Alzate, Kevin Pottie, Vivian Welch, Elie A Akl, Janet Jull, Eddy Lang, Srinivasa Vittal Katikireddi, Rachel Morton, Lehana Thabane, Bev Shea, Airton T Stein, Jasvinder Singh, Ivan D Florez, Gordon Guyatt, Holger Schünemann, Peter Tugwell
The availability of evidence-based guidelines does not ensure their implementation and use in clinical practice or policy making. Inequities in health have been defined as those inequalities within or between populations that are avoidable, unnecessary and also unjust and unfair. Evidence-based clinical practice and public health guidelines ('guidelines') can be used to target health inequities experienced by disadvantaged populations, although guidelines may unintentionally increase health inequities. For this reason, there is a need for evidence-based clinical practice and public health guidelines to intentionally target health inequities experienced by disadvantaged populations...
October 3, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29029048/general-practitioners-perception-of-being-a-doctor-in-urban-vs-rural-regions-in-germany-a-focus-group-study
#18
Nadine J Pohontsch, Heike Hansen, Ingmar Schäfer, Martin Scherer
Background: Inadequate recruitment numbers for GPs in rural regions give cause for concern. Working in rural regions is less attractive among medical students because of strong associations concerning a higher workload, restriction of privacy and demands exceeding their competences. We aimed to explore perceptions of GPs working in urban versus rural regions to contrast these prejudices. Methods: We conducted nine focus groups with GPs [female = 21, male = 44] from urban and rural regions, using a semi-structured guideline...
September 23, 2017: Family Practice
https://www.readbyqxmd.com/read/29028983/guidelines-on-informed-consent-in-anaesthesia-unrealistic-unethical-untenable%C3%A2
#19
A M Cyna, S W Simmons
No abstract text is available yet for this article.
October 4, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29028930/use-of-a-hand-held-digital-cognitive-aid-in-simulated-crises-the-max-randomized-controlled-trial
#20
R Lelaidier, B Balança, S Boet, A Faure, M Lilot, F Lecomte, J-J Lehot, T Rimmelé, J-C Cejka
Background: Cognitive aids improve the technical performance of individuals and teams dealing with high-stakes crises. Hand-held electronic cognitive aids have rarely been investigated. A randomized controlled trial was conducted to investigate the effects of a smartphone application, named MAX (for Medical Assistance eXpert), on the technical and non-technical performance of anaesthesia residents dealing with simulated crises. Methods: This single-centre randomized, controlled, unblinded trial was conducted in the simulation centre at Lyon, France...
September 27, 2017: British Journal of Anaesthesia
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