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https://www.readbyqxmd.com/read/29454162/anxiety-depression-and-asthma-control-changes-after-standardized-treatment
#1
Joaquin Sastre, Astrid Crespo, Toni Fernandez-Sanchez, Manuel Rial, Vicente Plaza
BACKGROUND: It has been documented that anxiety and depression are prevalent in patients with asthma and are associated with greater frequency of exacerbations, increased use of health-care resources, and poor asthma control. OBJECTIVES: Our study examined not only the association of asthma diagnosis with symptoms of depression/anxiety and asthma control at baseline, but also over a 6-month period of specialist supervision. METHODS: We enrolled 3,182 patients with moderate-severe asthma...
February 14, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29454063/characterization-of-nanomedicines-a-reflection-on-a-field-under-construction-needed-for-clinical-translation-success
#2
REVIEW
Jean-Baptiste Coty, Christine Vauthier
The nanotechnology revolution offers many expectations for the improvement of medicine treatments. At present, nanomedicine (NM) development is hampered by methodological barriers for a better characterization and a wider understanding of their in vivo behavior. While regulatory agencies setup guidelines to support NM translation from bench to bedside, the gap is still hardly overcome by main nanomedicines. One lever for filling this gap is a better characterization, thus increasing the global knowledge about the NM itself but also validate the confidence in terms of batch to batch reproducibility of such complex nano-objects...
February 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29453935/evaluation-of-cerebrospinal-fluid-phosphorylated-tau-231-as-a-biomarker-in-the-differential-diagnosis-of-alzheimer-s-disease-and-vascular-dementia
#3
Spomenka Kiđemet-Piskač, Mirjana Babić Leko, Antonela Blažeković, Lea Langer Horvat, Nataša Klepac, Zdenko Sonicki, Danijela Kolenc, Patrick R Hof, Marina Boban, Ninoslav Mimica, Fran Borovečki, Goran Šimić
BACKGROUND: The diagnosis of either Alzheimer's disease (AD) or vascular dementia (VaD) is still largely based on clinical guidelines and exclusion of other diseases that may lead to dementia. AIMS: In this study, we assessed whether the use of sensitive and specific biomarkers such as phosphorylated tau proteins could contribute to an earlier and more accurate diagnosis of AD and VaD, as well as to their differentiation. MATERIAL AND METHODS: A total of 198 patients, of which 152 had AD, 28 VaD, and 18 were healthy controls (HC), were included in the analyses...
February 17, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29453872/effect-of-dermatology-consultation-on-outcomes-for-patients-with-presumed-cellulitis-a-randomized-clinical-trial
#4
Lauren N Ko, Anna C Garza-Mayers, Jessica St John, Lauren Strazzula, Priyanka Vedak, Radhika Shah, Allison S Dobry, Sowmya R Rao, Leslie W Milne, Blair Alden Parry, Daniela Kroshinsky
Importance: Each year, cellulitis leads to 650 000 hospital admissions and is estimated to cost $3.7 billion in the United States. Previous literature has demonstrated a high misdiagnosis rate for cellulitis, which results in unnecessary antibiotic use and health care cost. Objective: To determine whether dermatologic consultation decreases duration of hospital stay or intravenous antibiotic treatment duration in patients with cellulitis. Design, Setting, and Participants: This randomized clinical trial was conducted in a large urban tertiary care hospital between October 2012 and January 2017, with 1-month follow-up duration...
February 16, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29453776/syndromic-sebaceous-nevus-current-findings
#5
Oumama El Ezzi, Anthony S de Buys Roessingh, Michèle Bigorre, Guillaume Captier
BACKGROUND: Sebaceous nevus is a congenital malformation of the skin that usually occurs on the scalp or face. Syndromic forms do rarely exist with associated cerebral and ocular malformations. The skin lesions are pale at birth and become irregular by puberty. In the adult patient, tumors (usually benign) develop from sebaceous nevus. Their surgical excision during childhood can give a better result in terms of the definitive scar. OBJECTIVES: The aim of this study is to analyze our cases of syndromic sebaceous hamartoma, perform a review of the existing literature, and propose guidelines for the therapeutic plan...
February 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29453716/occurrence-and-assessment-of-the-risk-of-ultraviolet-filters-and-light-stabilizers-in-victorian-estuaries
#6
Mayumi Allinson, Yutaka Kameda, Kumiko Kimura, Graeme Allinson
This reconnaissance study was undertaken to examine the occurrence of common ultraviolet filters (UVF) and light stabilizers (UVLS), and preservatives in four different estuaries in Port Philip Bay, Victoria, for the first time. In total, 11 UV filters, 10 UV stabilizers, 12 preservatives and a metabolite, and one fragrance were screened in grab samples of water and sediment using a combination of solid phase extraction and gas and liquid chromatography mass spectrometry measurement techniques. In that context, 16 of the UVF and UVLS and 5 of the preservatives screened were observed in water and/or sediment samples...
February 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29453701/eanm-guidelines-for-radionuclide-therapy-of-bone-metastases-with-beta-emitting-radionuclides
#7
Daria Handkiewicz-Junak, Thorsten D Poeppel, Lisa Bodei, Cumali Aktolun, Samer Ezziddin, Francesco Giammarile, Roberto C Delgado-Bolton, Michael Gabriel
The skeleton is the most common metastatic site in patients with advanced cancer. Pain is a major healthcare problem in patients with bone metastases. Bone-seeking radionuclides that selectively accumulate in the bone are used to treat cancer-induced bone pain and to prolong survival in selected groups of cancer patients. The goals of these guidelines are to assist nuclear medicine practitioners in: (a) evaluating patients who might be candidates for radionuclide treatment of bone metastases using beta-emitting radionuclides such as strontium-89 ( 89 Sr), samarium-153 ( 153 Sm) lexidronam ( 153 Sm-EDTMP), and phosphorus-32 ( 32 P) sodium phosphate; (b) performing the treatments; and...
February 16, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29453567/phagocytosis-by-sertoli-cells-analysis-of-main-phagocytosis-steps-by-confocal-and-electron-microscopy
#8
Marina G Yefimova, Nadia Messaddeq, Annie-Claire Meunier, Anne Cantereau, Bernard Jegou, Nicolas Bourmeyster
Sertoli cells were discovered in the seminiferous tubules by Enrico Sertoli in 1865 (Morgagni 7:31-33, 1865). Intense phagocytosis is, in the context of spermatogenesis cycle, morphologically the most noticeable function of Sertoli cells. In this chapter the major principles of phagocytosis machinery and its specificities in the seminiferous tubules will be briefly reviewed, guidelines of analysis of main phagocytosis steps by confocal and transmission electron microscopy will be described, and a simplified method to assess phagocytosis rate in routine experiments will be given...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29453552/hiv-related-stigma-social-support-and-psychological-distress-among-individuals-initiating-art-in-ethiopia
#9
Angela Parcesepe, Olga Tymejczyk, Robert Remien, Tsigereda Gadisa, Sarah Gorrell Kulkarni, Susie Hoffman, Zenebe Melaku, Batya Elul, Denis Nash
Recent World Health Organization HIV treatment guideline expansion may facilitate timely antiretroviral therapy (ART) initiation. However, large-scale success of universal treatment strategies requires a more comprehensive understanding of known barriers to early ART initiation. This work aims to advance a more comprehensive understanding of interrelationships among three known barriers to ART initiation: psychological distress, HIV-related stigma, and low social support. We analyzed cross-sectional interview data on 1175 adults initiating ART at six HIV treatment clinics in Ethiopia...
February 16, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29453533/the-role-of-autophagy-in-nanoparticles-induced-toxicity-and-its-related-cellular-and-molecular-mechanisms
#10
Yubin Li, Dianwen Ju
In the past decades, nanoparticles have been widely used in industry and pharmaceutical fields for drug delivery, anti-pathogen, and diagnostic imaging purposes because of their unique physicochemical characteristics such as special ultrastructure, dispersity, and effective cellular uptake properties. But the nanotoxicity has been raised over the extensive applications of nanoparticles. Researchers have elucidated series of mechanisms in nanoparticles-induced toxicity, including apoptosis, necrosis, oxidative stress, and autophagy...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29453511/developing-new-age-specific-prostate-specific-antigen-thresholds-for-testing-for-prostate-cancer
#11
Rebecca Gilbert, Kate Tilling, Richard M Martin, J Athene Lane, Michael Davis, Freddie C Hamdy, David E Neal, Jenny L Donovan, Chris Metcalfe
PURPOSE: To examine whether age-related reference ranges for "normal" prostate-specific antigen (PSA) change (determined in men without prostate cancer) can be used to identify men at high risk of having prostate cancer. METHODS: Subjects were men aged 50-69 years with PSA < 10 ng/mL from the UK-based Prostate Testing for cancer and Treatment (ProtecT) study. Men with prostate cancer were categorized as high or low risk of progression (Low risk: Gleason score ≤ 6 and stage T1-T2a; High risk: Gleason score 7-10 or stage T2C)...
February 16, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29453481/ventilator-associated-pneumonia-and-role-of-nurses-in-its-prevention
#12
Chadani Osti, Deepa Wosti, Bimala Pandey, Qinghua Zhao
Ventilator-associated pneumonia (VAP) is one of the most frequent nosocomial infections among ventilated patients in ICUs, associated with an increase in days of ICU stay, morbidity, and mortality. Its prevention is a significant concern in every hospital. Most of the interventions and prevention strategies are part of routine nursing care. Nurses have different vital roles such as care provider, manager, educator, coordinator, and evaluator in preventing VAP. Lack of knowledge of infection prevention and proper nursing care among nurses may become a barrier in adhering to evidence-based guidelines for preventing ventilator-associated pneumonia...
October 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/29453349/ultrasound-and-shock-wave-stimulation-to-promote-axonal-regeneration-following-nerve-surgery-a-systematic-review-and-meta-analysis-of-preclinical-studies
#13
Simeon C Daeschler, Leila Harhaus, Philipp Schoenle, Arne Boecker, Ulrich Kneser, Konstantin D Bergmeister
Limited regeneration after nerve injury often leads to delayed or incomplete reinnervation and consequently insufficient muscle function. Following nerve surgery, application of low-intensity ultrasound or extracorporeal shock waves may promote nerve regeneration and improve functional outcomes. Because currently clinical data is unavailable, we performed a meta-analysis following the PRISMA-guidelines to investigate the therapeutic effect of ultrasound and shock wave therapies on motor nerve regeneration. Ten ultrasound-studies (N = 445 rats) and three shock-wave studies (N = 110 rats) were identified from multiple databases...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453304/protocol-investigating-the-clinical-utility-of-an-objective-measure-of-attention-impulsivity-and-activity-qbtest-for-optimising-medication-management-in-children-and-young-people-with-adhd-qbtest-utility-for-optimising-treatment-in-adhd-quota-a-feasibility
#14
Charlotte L Hall, Marilyn James, Sue Brown, Jennifer L Martin, Nikki Brown, Kim Selby, Julie Clarke, Hena Vijayan, Boliang Guo, Kapil Sayal, Chris Hollis, Madeleine J Groom
INTRODUCTION: Attention-deficit hyperactivity disorder (ADHD) is characterised by symptoms of inattention, hyperactivity and impulsivity. To improve outcomes, the National Institute for Health and Care Excellence ADHD guidelines recommend regular monitoring of symptoms when children commence medication. However, research suggests that routine monitoring rarely happens, and clinicians often rely on subjective information such as reports from parents and teachers to ascertain improvement...
February 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29453301/role-of-the-family-doctor-in-the-management-of-adults-with-obesity-a-scoping-review
#15
Elizabeth A Sturgiss, Nicholas Elmitt, Emily Haelser, Chris van Weel, Kirsty A Douglas
OBJECTIVES: Obesity management is an important issue for the international primary care community. This scoping review examines the literature describing the role of the family doctor in managing adults with obesity. The methods were prospectively published and followed Joanna Briggs Institute methodology. SETTING: Primary care. Adult patients. INCLUDED PAPERS: Peer-reviewed and grey literature with the keywords obesity, primary care and family doctors...
February 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29453298/urban-green-spaces-and-cancer-a-protocol-for-a-scoping-review
#16
Marion Porcherie, Mathilde Lejeune, Marion Gaudel, Jeanine Pommier, Emmanuelle Faure, Zoé Heritage, Stéphane Rican, Jean Simos, Nicola Luca Cantoreggi, Anne Roué Le Gall, Linda Cambon, Jean-Philippe Regnaux
INTRODUCTION: Green space in the built environment is an important topic on the health agenda today. Studies have shown that access to green spaces is associated with better mental and physical health, yet green spaces can also be detrimental to health if they are not managed appropriately. Despite the increasing interest in urban green spaces, little research has so far been conducted into the links between green spaces and cancer. OBJECTIVE: The purpose of this scoping review is therefore to map the literature available on the types of relationship between urban green spaces and cancer...
February 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29453248/is-careful-assessment-of-rare-variants-in-the-ryr2-gene-piercing-the-guidelines-strong-armor
#17
EDITORIAL
Peter J Schwartz, Maria-Christina Kotta
No abstract text is available yet for this article.
February 2018: Circ Genom Precis Med
https://www.readbyqxmd.com/read/29453157/-the-spanish-society-of-paediatric-infectious-diseases-guidelines-on-the-prevention-diagnosis-and-treatment-of-neonatal-herpes-simplex-infections
#18
(no author information available yet)
Neonatal herpes simplex virus infections are rare, but are associated with significant morbidity and mortality. Most newborns acquire herpes simplex virus infection in the peripartum period. For peripartum transmission to occur, women must be shedding the virus in their genital tracts symptomatically or asymptomatically around the time of delivery. There are evidence-based interventions in pregnancy to prevent the transmission to the newborn. Caesarean section should be performed in the presence of herpetic lesions, and antiviral prophylaxis in the last weeks of pregnancy is recommended to suppress genital tract herpes simplex virus at the time of delivery...
February 13, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29453025/material-properties-of-the-brain-in-injury-relevant-conditions-experiments-and-computational-modeling
#19
Wei Zhao, Bryan Choate, Songbai Ji
Material properties of the brain have been extensively studied but remain poorly characterized. The vast variations in constitutive models and material constants are well documented. However, no study exists to translate the variations into disparities in impact-induced brain strains most relevant to brain injury. Here, we reviewed a subset of injury-relevant brain material properties either characterized in experiments or adopted in recent head injury models. To highlight how variations in measured brain material properties manifested in simulated brain strains, we selected six experiments that have provided a complete set of brain material model and constants to implement a common head injury model...
February 6, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29453020/2018-consensus-of-the-taiwan-society-of-cardiology-and-the-diabetes-association-of-republic-of-china-taiwan-on-the-pharmacological-management-of-patients-with-type-2-diabetes-and-cardiovascular-diseases
#20
Chern-En Chiang, Shih-Yi Lin, Tsung-Hsien Lin, Tzung-Dau Wang, Hung-I Yeh, Jung-Fu Chen, Chia-Ti Tsai, Yi-Jen Hung, Yi-Heng Li, Ping-Yen Liu, Kuan-Cheng Chang, Kang-Ling Wang, Ting-Hsing Chao, Kou-Gi Shyu, Wei-Shiung Yang, Kwo-Chang Ueng, Pao-Hsien Chu, Wei-Hsian Yin, Yen-Wen Wu, Hao-Min Cheng, Shyi-Jang Shin, Chien-Ning Huang, Lee-Ming Chuang, Shing-Jong Lin, San-Jou Yeh, Wayne Huey-Herng Sheu, Jiunn-Lee Lin
The global incidence and prevalence of type 2 diabetes have been escalating in recent decades. Patients with type 2 diabetes have an increased risk of atherosclerotic cardiovascular disease (ASCVD). About two-thirds of death in type 2 diabetes are due to ASCVD, including 40% from coronary heart disease (CHD), 15% from heart failure (HF), and 10% from stroke. The association between hyperglycemia and elevated CV risk has been demonstrated in multiple cohort studies. However, clinical trials of intensive glucose reduction did not significantly reduce macrovascular outcomes...
February 13, 2018: Journal of the Chinese Medical Association: JCMA
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