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https://www.readbyqxmd.com/read/29451216/does-combined-therapy-of-curcumin-and-epigallocatechin-gallate-have-a-synergistic-neuroprotective-effect-against-spinal-cord-injury
#1
Jiri Ruzicka, Lucia Machova Urdzikova, Barbora Svobodova, Anubhav G Amin, Kristyna Karova, Jana Dubisova, Kristyna Zaviskova, Sarka Kubinova, Meic Schmidt, Meena Jhanwar-Uniyal, Pavla Jendelova
Systematic inflammatory response after spinal cord injury (SCI) is one of the factors leading to lesion development and a profound degree of functional loss. Anti-inflammatory compounds, such as curcumin and epigallocatechin gallate (EGCG) are known for their neuroprotective effects. In this study, we investigated the effect of combined therapy of curcumin and EGCG in a rat model of acute SCI induced by balloon compression. Immediately after SCI, rats received curcumin, EGCG, curcumin + EGCG or saline [daily intraperitoneal doses (curcumin, 6 mg/kg; EGCG 17 mg/kg)] and weekly intramuscular doses (curcumin, 60 mg/kg; EGCG 17 mg/kg)] for 28 days...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29439907/posterior-spinal-cord-shift-does-not-affect-surgical-outcomes-after-muscle-preserving-selective-laminectomy
#2
Satoshi Nori, Tateru Shiraishi, Ryoma Aoyama, Ken Ninomiya, Junichi Yamane, Kazuya Kitamura, Seiji Ueda
Postoperative posterior spinal cord shift (PSS) has been considered a required radiographic endpoint of posterior decompression procedures. To achieve PSS, laminoplasty for cervical compressive myelopathy (CCM) has been consecutively performed on four or more laminae (C2-C7, C3-C7, or C3-C6). However, the clinical significance of PSS remains controversial. By selecting the surgically treated laminae, selective laminectomy (SL) can achieve adequate decompression without disturbing the extensor musculature and facet joints...
February 10, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29436375/scalp-acupuncture-for-the-treatment-of-motor-function-in-acute-spinal-cord-injury-a-case-report
#3
Colette Widrin
An acute spinal cord injury (SCI) is the result of a traumatic injury to the spinal cord caused by a contusion, compression or severing of the spinal cord. There are approximately 17,000 new cases each year, of which, males account for 80%. Approximately 65% of these injuries cause incomplete, or partial, damage to the spinal cord. Comprehensive treatment is essential to restore maximum function. Surgical procedures, stem cell therapy, pharmaceutical agents and physical therapy are employed to minimize and repair damage done to the nervous system...
January 31, 2018: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29429245/-effects-of-expanded-anterolateral-approach-for-tibial-plateau-fractures-involved-the-posterolateral-column
#4
Y W Zhao, J B Xie, G Z Ding
Objective: To explore the short-term effects of expanded anterolateral approach in treating fracture involved the posterolateral tibial plateau. Methods: A retrospective analysis of the clinical data from 16 patients undergoing extended anterolateral approach for fracture involved the posterolateral tibial plateau in the First Affiliated Hospital of Wannan Medical College between January 2013 and July 2016 was done. The patients were treated with 3.5 mm proximal "L" type proximal tibial locking compression plate with four locking screws through the nail row technique...
January 30, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29424166/-case-control-study-on-reduction-for-external-and-posterior-malleolar-fractures-combined-with-compressive-articular-surface-through-tibiafibular-fractures-region
#5
Guo-Fu Chen, Chun-Li Xu, Bin Wang, Jun-Bo Liang, Chuan-Yi Zhang, Wei Wang
OBJECTIVE: To compare clinical outcomes of external and posterior malleolar fractures associated with compressive articular surface through posteriorlateral incision and posteriormedial incision. METHODS: From January 2012 to January 2015, 52 patients with external and posterior malleolar fractures associated with compressive articular surface were treated by interfix. Among them, 24 patients were treated through posteriourlateral incision, including 16 males and 8 females, aged from 20 to 65 years old with an average of(35...
June 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29417777/-effect-of-different-bone-cement-dispersion-types-in-the-treatment-of-osteoporotic-vertebral-compression-fracture
#6
Yong-Sheng Zhao, Qiang Li, Qiang Li, Yan-Ping Zheng
OBJECTIVE: To observe different bone cement dispersion types of PVP, PKP and manipulative reduction PVP and their effects in the treatment of senile osteoporotic vertebral compression fractures and the bone cement leakage rate. METHODS: The clinical data of patients with osteoporotic vertebral compression fractures who underwent unilateral vertebroplasty from January 2012 to January 2015 was retrospectively analyzed. Of them, 56 cases including 22 males and 34 females aged from 60 to 78 years old were treated by PVP operation; Fouty-eight cases including 17 males and 31 females aged from 61 to 79 years old were treated by PKP operation; Forty-three cases including 15 males and 28 females aged from 60 to 76 years old were treated by manipulative reduction PVP operation...
May 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29414122/examining-mechanical-properties-of-various-pharmaceutical-excipients-with-the-gravitation-based-high-velocity-compaction-analysis-method
#7
Timo Tanner, Osmo Antikainen, Henrik Ehlers, David Blanco, Jouko Yliruusi
The compression physics of powders must be considered when developing a suitable tablet formulation. In the present study, the gravitation-based high-velocity method was utilized to analyze mechanical properties of eight common pharmaceutical excipients: two grades of lactose, anhydrous glucose, anhydrous calcium hydrogen phosphate, three grades of microcrystalline cellulose and starch. Samples were compressed five times consecutively with varying pressure and speed so that Setup A produced higher pressure and longer contact time than Setup B...
January 30, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29411738/surgical-management-of-distal-biceps-tendon-anatomical-reinsertion-complications-iatrogenic-posterior-interosseous-nerve-palsy
#8
Paweł Reichert, Aleksandra Królikowska, Jarosław Witkowski, Łukasz Szuba, Andrzej Czamara
BACKGROUND Although iatrogenic posterior interosseous nerve (PIN) palsy is an uncommon complication of ruptured distal biceps brachii tendon surgical anatomical reinsertion, it is the most severe complication leading to functional limitation. The present study investigated possible types of PIN palsy as a postoperative complication of anatomical distal biceps tendon reinsertion, and aimed to clinically assess patients at 2 years after its surgical treatment. MATERIAL AND METHODS The studied sample comprised 7 male patients diagnosed with an iatrogenic PIN palsies after anatomical reinsertion of the distal biceps tendon, who were referred to the reference center for management of a peripheral nervous system injury...
February 7, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29410338/diffusion-tensor-imaging-of-axonal-and-myelin-changes-in-classical-trigeminal-neuralgia
#9
Yanyang Zhang, Zhiqi Mao, Cui Zhiqiang, Zhipei Ling, Longsheng Pan, Xinyun Liu, Jun Zhang, Xinguang Yu
Trigeminal neuralgia (TN) is commonly associated with pathological factors of axonopathy and demyelination resulting from neurovascular compression at the trigeminal root entry zone (REZ). Decompression surgery can relieve TN pain, likely by resolving such structural abnormalities. To test this hypothesis, we used diffusion tensor imaging (DTI) to capture the full extent of trigeminal microarchitecture changes in vivo in TN patients. Twenty-four TN patients were compared to 28 controls. DTI metrics of fractional anisotropy (FA) as well as mean, parallel, and perpendicular diffusivities (MD,λǁ, and λ⊥, respectively) were calculated in isolation at each trigeminal REZ...
February 1, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29408783/incorporation-of-prior-knowledge-of-signal-behavior-into-the-reconstruction-to-accelerate-the-acquisition-of-diffusion-mri-data
#10
Juan F P J Abascal, Manuel Desco, Juan Parra-Robles
Diffusion MRI data are generally acquired using hyperpolarized gases during patient breath-hold, which yields a compromise between achievable image resolution, lung coverage, and number of -values. In this paper, we propose a novel method that accelerates the acquisition of diffusion MRI data by undersampling in both the spatial and -value dimensions and incorporating knowledge about signal decay into the reconstruction (SIDER). SIDER is compared with total variation (TV) reconstruction by assessing its effect on both the recovery of ventilation images and the estimated mean alveolar dimensions (MADs)...
February 2018: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29408649/endoscopic-endonasal-transphenoidal-approachvisual-outcome-in-pituitary-macroadenomas-quantitative-assessment-with-diffusion-tensor-imaging-dti-early-and-long-term-results
#11
Ihsan Anik, Yonca Anik, Burak Cabuk, Melih Caklili, Dilara Pirhan, Onural Ozturk, Musa Cirak, Savas Ceylan
BACKGROUND: Postoperative visual recovery in patients with pituitary adenoma can be influenced by the duration of symptoms, age, and tumor volume. Diffusion tensor imaging (DTI) allows visualization of white matter structure along with quantitative information. The aims of our study were to predict the visual recovery process in the early and long-term periods and to define the parameters affecting the recovery course. MATERIAL METHODS: A total of 200 patients with pituitary macroadenomas underwent endoscopic transphenoidal surgery between January 2009 and July 2016...
February 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29402359/-predictive-value-of-partial-pressure-of-end-tidal-carbon-dioxide-on-the-effect-of-active-abdominal-compression-decompression-cardiopulmonary-resuscitation-and-serum-s100b-protein-on-cerebral-function
#12
Hongwei Wang, Xin Sha, Sisen Zhang, Xianfa Jiao, Longxian Zhao, Yingxin Cen, Wei Song, Jing Li, Lixiang Wang
OBJECTIVE: To explore the predictive value of partial pressure of end-tidal carbon dioxide (PETCO2) on the effect of active abdominal compression-decompression cardiopulmonary resuscitation (AACD-CPR) and serum S100B protein on cerebral function. METHODS: 142 adult patients with in-hospital cardiac arrest (IHCA) AACD-CPR in Zhengzhou People's Hospital, Affiliated Southern Medical University from September 2014 to December 2017 were enrolled. Patients were divided into successful group and failure group according to restoration of spontaneous circulation (ROSC) or not; and then according to Glasgow-Pittsburgh cerebral performance categories (CPC) one month after ROSC, the successful group was divided into good prognosis group (CPC 1-2) and poor prognosis group (CPC 3-5) further...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29399376/isolated-ligamentum-flavum-ossification-in-primary-hypoparathyroidism
#13
Amir H Sohail, Muhammad A A Maan, Muhammad S Khan, Qamar Masood
Background: The ligamenta flava can undergo ossification and calcification resulting in myelopathy. Only seven cases of ligamentum flavum ossification in association with hypoparathyroidism have been reported, most of which had concurrent osseous changes in other spinal ligaments. Here, we report a patient with hypoparathyroidism who presented with ligamentum flavum ossification causing both cervical and thoracic myelopathy. Case Description: A 43-year-old male presented with backache, urinary retention, and lower limb weakness for the last few days...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29399061/neuroprotective-effect-of-local-hypothermia-in-a-computer-controlled-compression-model-in-minipig-correlation-of-tissue-sparing-along-the-rostro-caudal-axis-with-neurological-outcome
#14
Stefania Gedrova, Jan Galik, Martin Marsala, Monika Zavodska, Jaroslav Pavel, Igor Sulla, Miroslav Gajdos, Imrich Lukac, Jozef Kafka, Valent Ledecky, Igor Sulla, Martina Karasova, Peter Reichel, Alexandra Trbolova, Igor Capik, Viktoria Lukacova, Katarina Bimbova, Maria Bacova, Andrea Stropkovska, Nadezda Lukacova
This study investigated the neuroprotective efficacy of local hypothermia in a minipig model of spinal cord injury (SCI) induced by a computer-controlled impactor device. The tissue integrity observed at the injury epicenter, and up to 3 cm cranially and caudally from the lesion site correlated with motor function. A computer-controlled device produced contusion lesions at L3 level with two different degrees of tissue sparing, depending upon pre-set impact parameters (8N- and 15N-force impact). Hypothermia with cold (4°C) saline or Dulbecco's modified Eagle's medium (DMEM)/F12 culture medium was applied 30 min after SCI (for 5 h) via a perfusion chamber (flow 2 ml/min)...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29394951/analysis-of-c5-palsy-in-cervical-myelopathy-with-massive-anterior-compression-following-laminoplasty
#15
Guangdong Chen, Yifan Wang, Zhidong Wang, Ruofu Zhu, Huilin Yang, Zongping Luo
BACKGROUND: Little data is available about comparison of the incidence and clinical characteristics of the C5 palsy between patients of cervical myelopathy with occupying ratio greater than 50% and those with occupying ratio less than 50% following laminoplasty. METHODS: One-hundred eighteen patients with cervical myelopathy who underwent open door laminoplasty were reviewed in this study. The patients were divided into two groups: group A comprising 55 patients with an anterior occupying ratio greater than 50% and group B comprising 63 patients with an anterior occupying less than 50%...
February 2, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29392079/novel-modification-of-potassium-chloride-induced-cardiac-arrest-model-for-aged-mice
#16
Huaqin Liu, Zhui Yu, Ying Li, Bin Xu, Baihui Yan, Wulf Paschen, David S Warner, Wei Yang, Huaxin Sheng
Experimental cardiac arrest (CA) in aging research is infrequently studied in part due to the limitation of animal models. We aimed to develop an easily performed mouse CA model to meet this need. A standard mouse KCl-induced CA model using chest compressions and intravenous epinephrine for resuscitation was modified by blood withdrawal prior to CA onset, so as to decrease the requisite KCl dose to induce CA by decreasing the circulating blood volume. The modification was then compared to the standard model in young adult mice subjected to 8 min CA...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29390530/nonsurgical-management-of-an-extensive-spontaneous-spinal-epidural-hematoma-causing-quadriplegia-and-respiratory-distress-in-a-choledocholithiasis-patient-a-case-report
#17
Kyle Raasck, Jason Khoury, Ahmed Aoude, Fahad Abduljabbar, Peter Jarzem
RATIONALE: Spontaneous spinal epidural hematoma (SSEH) manifests from blood accumulating in the epidural space, compressing the spinal cord, and leading to acute neurological deficits. The disease's cloudy etiology and rarity contribute to dangerously suboptimal therapeutic principles. These neural deficits can be permanent, even fatal, if the SSEH is not treated in a timely and appropriate manner. Standard therapy is decompressive laminectomy, though nonsurgical management is a viable course of action for patients who meet a criterion that is continuously being refined...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390447/cervical-myelopathy-caused-by-invaginated-laminae-of-the-axis-associated-with-occipitalizaion-of-the-atlas-case-report-and-literature-review
#18
Jian-Xiang Xu, Cheng-Gui Wang, Cheng-Wei Zhou, Qian Tang, Jia-Wei Li, Hua-Zi Xu, Fang-Min Mao, Nai-Feng Tian
RATIONALE: In previous studies, few cases of cervical myelopathy caused by invaginated anomalous laminae of the axis have been reported, and none of them was combined with occipitalization of the atlas. PATIENT CONCERNS: A 28-year-old male was brought to our hospital with motor and sensory impairments of the extremities after a car accident. DIAGNOSES: MRI showed the spinal cord was markedly compressed at the C2/3 level. Reconstructed CT scans revealed an invaginated laminae of axis into the spinal canal as well as atlas assimilation...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390439/superior-vena-cava-syndrome-secondary-to-recurrent-coronary-artery-fistula-a-case-report-and-literature-review
#19
Peng-Fei Chen, Liang Tang, Zhen-Zhen Liu, Xinqun Hu
RATIONALE: Coronary artery fistula (CAF) is characterized by an abnormal communication of a coronary artery with a cardiac chamber or a great vessel bypassing the capillary bed. Surgical closure of large or symptomatic CAF is the gold standard treatment. However the previously closed CAF still has the possibility to reopen. Superior vena cava syndrome (SVCS) is defined as a condition that occurs when the obstruction of the superior vena cava interrupts blood flow from the head, upper extremities, and thorax to the right atrium and can present a life-threatening situation...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29383291/orbital-apex-metastasis-from-adenoid-cystic-carcinoma-acute-loss-of-vision-and-subsequent-recovery-with-the-radiation
#20
REVIEW
Lauren Crawford, Sanjeev Sharma
Orbital apex metastasis from adenoid cystic carcinoma (ACC) is rare. We present a patient with known metastatic ACC presented with a rapidly declining vision with visual acuity oculus dexter (OD) equal to counting fingers at two feet. On imaging, she was found to have a right orbital apex tumor causing compressive optic neuropathy. She received the intensity modulated radiation therapy (IMRT). After completion of the therapy, she had regained essentially a full vision with visual acuity OD of 20/30 without corrective lenses...
November 22, 2017: Curēus
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