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https://www.readbyqxmd.com/read/29049814/cost-effectiveness-of-testing-and-treatment-for-latent-tuberculosis-infection-in-residents-born-outside-the-united-states-with-and-without-medical-comorbidities-in-a-simulation-model
#1
Abriana Tasillo, Joshua A Salomon, Thomas A Trikalinos, C Robert Horsburgh, Suzanne M Marks, Benjamin P Linas
Importance: Testing for and treating latent tuberculosis infection (LTBI) is among the main strategies to achieve TB elimination in the United States. The best approach to testing among non-US born residents, particularly those with comorbid conditions, is uncertain. Objective: To estimate health outcomes, costs, and cost-effectiveness of LTBI testing and treatment among non-US born residents with and without medical comorbidities. Design, Setting, and Participants: Decision analytic tree and Markov cohort simulation model among non-US born residents with no comorbidities, with diabetes, with HIV infection, or with end-stage renal disease (ESRD) using a health care sector perspective with 3% annual discounting...
October 16, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29026744/profile-of-drug-resistant-tuberculosis-in-western-maharashtra
#2
Sudhakar W More, Malangori Abdulgani Parande, Sanjeev W Kamble, Manjunath S Kamble
CONTEXT: Drug-resistant tuberculosis (TB) strains have evolved mainly due to incomplete or improper treatment of TB patients and are one of the hurdles in controlling TB problem. It is better to understand the magnitude and comorbidities associated with drug-resistant TB. AIM AND OBJECTIVES: (1) To study some of the sociodemographic profile and history of TB treatment of drug-resistant TB cases. (2) To study their drug-resistance pattern and their comorbidity profile...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28947405/risk-factors-for-mortality-in-patients-with-tuberculosis-and-hiv-in-douala-cameroon
#3
N E Essomba, P G Ngaba, M P Halle, Y Afane-Voundi, Y Coppieters
Despite prevention efforts, and free treatment, TB-HIV co-infection still occurs in Cameroon. The objective of this work is to present the risk factors for mortality in patients co-infected with TB and HIV in Douala from 2009 to 2014. This transversal, analytic, and retrospective study took place from November 2014 to May 2015 in the Laquintinie Hospital in Douala. A review of our records identified patients aged at least 15 years, with this co-infection who received TB treatment, with or without antiretroviral agents...
August 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28947041/treatment-outcomes-of-rifampin-sparing-treatment-in-patients-with-pulmonary-tuberculosis-with-rifampin-mono-resistance-or-rifampin-adverse-events-a-retrospective-cohort-analysis
#4
Shinhee Park, Kyung-Wook Jo, Sang Do Lee, Woo Sung Kim, Tae Sun Shim
BACKGROUND: Rifampin (RIF) mono-resistant tuberculosis (RMR-TB) is a rare disease. Current guidelines recommend that RMR-TB be treated as multidrug-resistant TB (MDR-TB) but the evidence is scarce. METHODS: We conducted a retrospective cohort study on pulmonary TB patients to investigate the characteristics and outcomes of RMR-TB. The characteristics of RMR-TB were compared with those with adverse events to rifampin (RAE-TB). RESULTS: Forty-four RMR-TB and 29 RAE-TB patients were enrolled...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28912165/holistic-care-of-complicated-tuberculosis-in-healthcare-settings-with-limited-resources
#5
Trevor Duke, Sharon Kasa Tom, Harry Poka, Henry Welch
In recent years, most of the focus on improving the quality of paediatric care in low-income countries has been on improving primary care using the Integrated Management of Childhood Illness, and improving triage and emergency treatment in hospitals aimed at reducing deaths in the first 24 hours. There has been little attention paid to improving the quality of care for children with chronic or complex diseases. Children with complicated forms of tuberculosis (TB), including central nervous system and chronic pulmonary TB, provide examples of acute and chronic multisystem paediatric illnesses that commonly present to district-level and second-level referral hospitals in low-income countries...
September 14, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28910369/heightened-circulating-levels-of-antimicrobial-peptides-in-tuberculosis-diabetes-co-morbidity-and-reversal-upon-treatment
#6
Nathella Pavan Kumar, Kadar Moideen, Vijay Viswanathan, Shanmugam Sivakumar, Pradeep A Menon, Hardy Kornfeld, Subash Babu
BACKGROUND: The association of antimicrobial peptides (AMPs) with tuberculosis-diabetes comorbidity (PTB-DM) is not well understood. METHODS: To study the association of AMPs with PTB-DM, we examined the systemic levels of cathelicidin (LL37), human beta defensin- 2 (HBD2), human neutrophil peptides 1-3, (HNP1-3) and granulysin in individuals with either PTB-DM, PTB, latent TB (LTB) or no TB infection (NTB). RESULTS: Circulating levels of cathelicidin and HBD2 were significantly higher and granulysin levels were significantly lower in PTB-DM compared to PTB, LTB or NTB, while the levels of HNP1-3 were significantly higher in PTB-DM compared to LTB or NTB individuals...
2017: PloS One
https://www.readbyqxmd.com/read/28825568/risk-factors-associated-with-tuberculosis-mortality-in-adults-in-six-provinces-of-argentina
#7
Elsa Zerbini, Adriana Greco, Silvia Estrada, Mario Cisneros, Carlos Colombo, Soledad Beltrame, Carina Boncompain, Sebastián Genero
Tuberculosis (TB) remains a cause of illness and death across the world, especially in developing countries and vulnerable population groups. In 2013, 1.5 million died from the disease worldwide. In Argentina, the largest proportion of TB-related deaths occurred in the northern provinces. Several international studies reported that TB mortality was related to the presence of certain comorbidities and socio-demographic characteristics. Our aim was to investigate the main risk factors associated with TB mortality in adults from six provinces in Argentina, especially those with higher TB mortality rates...
2017: Medicina
https://www.readbyqxmd.com/read/28759425/managing-cutaneous-tuberculosis-a-case-report
#8
Bettina M Brown-Gallardo
Tuberculosis (TB) continues to be a prevalent disease worldwide; an estimated one third of the world's population is infected and 2015 data from the World Health Organization show 10 million people had an active infection. Although TB often is cited as a disease that most commonly occurs in underdeveloped countries, the evolution of drug-resistant forms of TB and infection sensitivity of immunocompromised individuals have made this disease a focal point for indus- trialized countries as well. When TB is spread, it commonly affects the lungs, but it can infect any organ of the body...
July 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28663285/inhibitory-effects-of-selected-antituberculosis-drugs-on-common-human-hepatic-cytochrome-p450-and-udp-glucuronosyltransferase-enzymes
#9
Lei Cao, David J Greenblatt, Awewura Kwara
The comorbidities of tuberculosis and diseases such as HIV require long-term treatment with multiple medications. Despite substantial in vitro and in vivo information on effects of rifampicin and isoniazid on human CYPs, there is limited published data regarding the inhibitory effects of other anti-TB drugs on human CYPs and UGTs. The inhibitory effects of five first-line anti-TB drugs (isoniazid, rifampicin, pyrazinamide, ethambutol, and rifabutin), and the newly approved bedaquiline, were evaluated for six common human hepatic UGT enzymes (UGT1A1, 1A4, 1A6, 1A9, 2B7 and 2B15) in vitro using HLMs...
September 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28515464/systems-immunology-of-diabetes-tuberculosis-comorbidity-reveals-signatures-of-disease-complications
#10
Cesar A Prada-Medina, Kiyoshi F Fukutani, Nathella Pavan Kumar, Leonardo Gil-Santana, Subash Babu, Flávio Lichtenstein, Kim West, Shanmugam Sivakumar, Pradeep A Menon, Vijay Viswanathan, Bruno B Andrade, Helder I Nakaya, Hardy Kornfeld
Comorbid diabetes mellitus (DM) increases tuberculosis (TB) risk and adverse outcomes but the pathological interactions between DM and TB remain incompletely understood. We performed an integrative analysis of whole blood gene expression and plasma analytes, comparing South Indian TB patients with and without DM to diabetic and non-diabetic controls without TB. Luminex assay of plasma cytokines and growth factors delineated a distinct biosignature in comorbid TBDM in this cohort. Transcriptional profiling revealed elements in common with published TB signatures from cohorts that excluded DM...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28514999/severe-hypovitaminosis-d-in-active-tuberculosis-patients-and-its-predictors
#11
Qiuzhen Wang, Yufeng Liu, Yan Ma, Lei Han, Mei Dou, Yue Zou, Limei Sun, Hong Tian, Tongxia Li, Guofeng Jiang, Baoli Du, Tingyan Kou, Jiaqi Song, Frans J Kok, Evert G Schouten
BACKGROUND & AIMS: Tuberculosis (TB) patients have a significant vitamin D deficiency (VDD) endemic, which may be closely related to the onset and progress of the disease. The comorbidity of diabetes (DM) and TB has posed an increasing challenge in recent years. However, the influence of DM on TB and the possible mechanism are still uncertain. We carried out this study to identify the nutritional status of vitamin D (VD) in TB patients in a northern city in China (latitude 36° N) and investigate the possible predictors of severe vitamin D deficiency (SVDD)...
April 30, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28492777/tuberculosis-and-diabetes-probabilistic-linkage-of-databases-to-study-the-association-between-both-diseases
#12
Ricardo Gadelha de Abreu, Artur Iuri Alves de Sousa, Maria Regina Fernandes de Oliveira, Mauro Niskier Sanchez
OBJECTIVE: to describe the profile of cases of tuberculosis and diabetes comorbidity in Brazil. METHODS: this is a descriptive study with data from the Brazilian Information System for Notifiable Diseases - tuberculosis (Sinan-TB) and from the System of Registration and Monitoring of Hypertension and Diabetes Mellitus (Hiperdia), from 2007 to 2011; probabilistic linkage was carried out with Reclink software. RESULTS: 24,443 cases of comorbidity were found, including 3,181 cases not registered on Sinan-TB; of the total number of recovered cases, mostly were males (57...
April 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28423031/comorbidities-of-rheumatoid-arthritis-results-from-the-korean-national-health-and-nutrition-examination-survey
#13
Hyemin Jeong, Sun Young Baek, Seon Woo Kim, Yeong Hee Eun, In Young Kim, Hyungjin Kim, Jaejoon Lee, Eun-Mi Koh, Hoon-Suk Cha
This study aimed to evaluate the prevalence of comorbidities in patients with rheumatoid arthritis (RA) compared with the non-RA population. The 2010-2012 Korea National Health and Nutrition Examination Survey (KNHANES), which assesses the general health status of populations in South Korea using interviews and basic health assessment, was analyzed retrospectively. Weighted prevalence and odds ratio (OR) of comorbidities were analyzed in patients with RA compared with the non-RA population. The overall weighted (n = 37,453,158) prevalence of RA was 1...
2017: PloS One
https://www.readbyqxmd.com/read/28286903/the-risk-of-tuberculosis-in-sle-patients-from-an-asian-tertiary-hospital
#14
Yong Yang, Julian Thumboo, Ban Hock Tan, Thuan Tong Tan, Chern Hui Jeffrey Fong, Han Seong Ng, Kok Yong Fong
Systemic lupus erythematosus (SLE) has been associated with increased risk of tuberculosis (TB). However, little is known about the extent and risk factors for TB among Asian patient with SLE. We aimed to assess the rate of TB in patients with SLE, and investigate the risk of SLE on TB development using hospital administrative database. This is an historical cohort study of hospital discharge database from 2004 to 2011 to identify cases with SLE and TB using International Statistical Classification of Diseases and Related Health Problems, 9th Revision, Australian Modification (ICD-9-AM) codes...
June 2017: Rheumatology International
https://www.readbyqxmd.com/read/28250986/severe-tuberculosis-requiring-intensive-care-a-descriptive-analysis
#15
Raquel Pacheco Duro, Paulo Figueiredo Dias, Alcina Azevedo Ferreira, Sandra Margarida Xerinda, Carlos Lima Alves, António Carlos Sarmento, Lurdes Campos Dos Santos
Background. This study aims to describe the characteristics of tuberculosis (TB) patients requiring intensive care and to determine the in-hospital mortality and the associated predictive factors. Methods. Retrospective cohort study of all TB patients admitted to the ICU of the Infectious Diseases Department of Centro Hospitalar de São João (Porto, Portugal) between January 2007 and July 2014. Comorbid diagnoses, clinical features, radiological and laboratory investigations, and outcomes were reviewed. Univariate analysis was performed to identify risk factors for death...
2017: Critical Care Research and Practice
https://www.readbyqxmd.com/read/28245710/diabetes-and-pulmonary-tuberculosis-a-global-overview-with-special-focus-on-the-situation-in-asian-countries-with-high-tb-dm-burden
#16
Chunlan Zheng, Minhui Hu, Feng Gao
BACKGROUND: The double burden of tuberculosis (TB) and diabetes mellitus (DM) is hitting certain Asian countries harder than other areas. In a global estimate, 15% of all TB cases could be attributable to DM, with 40% of those cases coming from India and China. Many other countries of South, East, and South-East Asia are of particular concern given their TB burdens, large projected increases in DM prevalence, and population size. OBJECTIVE: In this narrative review, we aimed to: (i) give an overall insight into the evidence on TB-DM epidemiology from high double burden Asian countries, (ii) present the evidence on bi-directional screening implementation in this region, (iii) discuss possible factors related to higher TB susceptibility of Asian diabetic patients, and (iv) identify TB-DM comorbidity treatment challenges...
2017: Global Health Action
https://www.readbyqxmd.com/read/28222109/ppd-induced-monocyte-mitochondrial-damage-is-associated-with-a-protective-effect-to-develop-tuberculosis-in-bcg-vaccinated-individuals-a-cohort-study
#17
Diana Marín, Nancy Marín, Helena Del Corral, Lucelly López, María Elena Ramirez-Agudelo, Carlos A Rojas, María P Arbeláez, Luis F García, Mauricio Rojas
INTRODUCTION: The mechanisms of mononuclear phagocyte death have been associated with the permissiveness and resistance to mycobacterial replication, but it remains unknown whether or not they help predict the risk of developing TB. OBJECTIVE: To describe the factors associated with the induction of monocyte mitochondrial and membrane damage in response to PPD as well as determine if this type of damage might predict the susceptibility of developing active tuberculosis in a cohort of household contacts (HHCs) from Medellin, Colombia from 2005 to 2008...
2017: PloS One
https://www.readbyqxmd.com/read/28190404/determinants-of-mortality-in-elderly-patients-with-tuberculosis-a-population-based-follow-up-study
#18
Y-F Yen, J-Y Feng, S-W Pan, P-H Chuang, V Y-F Su, W-J Su
Elderly individuals with tuberculosis (TB) are more likely to have a non-specific clinical presentation of TB and high mortality. However, factors associated with mortality in elderly TB patients have not been extensively studied. This retrospective cohort study aimed to identify factors associated with death among elderly Taiwanese with TB. All elderly patients with TB from 2006 to 2014 in Taipei, Taiwan, were included in a study. Multiple logistic regression was used to identify the factors associated with death in elderly TB patients...
May 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28183335/efficacy-of-vitamin-d3-supplementation-in-reducing-incidence-of-pulmonary-tuberculosis-and-mortality-among-hiv-infected-tanzanian-adults-initiating-antiretroviral-therapy-study-protocol-for-a-randomized-controlled-trial
#19
Christopher R Sudfeld, Ferdinand Mugusi, Said Aboud, Tumaini J Nagu, Molin Wang, Wafaie W Fawzi
BACKGROUND: HIV-infected adults initiating antiretroviral therapy (ART) in sub-Saharan Africa continue to experience high rates of morbidity and mortality during the initial months of treatment. Observational studies in high-income and resource-limited settings indicate that HIV-infected adults with low vitamin D levels may be at increased risk of mortality, HIV disease progression, and incidence of pulmonary tuberculosis (TB). As a result, vitamin D3 supplementation may improve survival and treatment outcomes for HIV-infected adults initiating ART...
February 10, 2017: Trials
https://www.readbyqxmd.com/read/28178122/mortality-after-portal-vein-embolization-two-case-reports
#20
Eung Chang Lee, Sang-Jae Park, Sung-Sik Han, Hyeong Min Park, Seung Duk Lee, Seong Hoon Kim, In Joon Lee, Hyun Beom Kim
Portal vein embolization (PVE) is increasingly performed worldwide to reduce the possibility of liver failure after extended hepatectomy, by inducing future liver remnant (FLR) hypertrophy and atrophy of the liver planned for resection. The procedure is known to be very safe and to have few procedure-related complications.In this study, we described 2 elderly patients with Bismuth-Corlette type IV Klatskin tumor who underwent right trisectional PVE involving the embolization of the right portal vein, the left medial sectional portal branch, and caudate portal vein...
February 2017: Medicine (Baltimore)
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