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Tb and comorbid diseases

Balewgizie Sileshi Tegegne, Tesfa Dejenie Habtewold, Melkamu Merid Mengesha, Johannes G M Burgerhof
INTRODUCTION: Multi-drug-resistant tuberculosis (MDR-TB) has emerged as a challenge to global tuberculosis (TB) control and remains a major public health concern in many countries. Diabetes mellitus (DM) is an increasingly recognized comorbidity that can both accelerate TB disease and complicate its treatment. The aim of this study is to summarize available evidence on the association of DM and MDR-TB among TB patients and to provide a pooled estimate of risks. METHODS: All studies published in English before October 2016 will be searched using comprehensive search strings through PubMed, EMBASE, Web of Science, and WHO Global Health Library databases which have reported the association of DM and MDR-TB in adults with TB (age > =15)...
January 14, 2017: Systematic Reviews
Ruxana T Sadikot
Several studies have been done in relation to recurrence of tuberculosis (TB) following completion of treatment. However, recurrence of TB is still a major problem from a public health perspective in high-burden countries, where no special attention is being given to this issue. Disease recurrence is an important indicator of the efficacy of antituberculosis treatment. The rate of recurrence is highly variable and has been estimated to range from 4.9% to 25%. This variability is not only a reflection of regional epidemiology of recurrence but differences in the definitions used by the TB control programs...
December 2016: International Journal of Mycobacteriology
Alimuddin Zumla, Markus Maeurer
Tuberculosis (TB) causes 1.3 million deaths annually. There are 0.5 million cases of multidrug resistant TB (MDR-TB) and the number of cases is rising globally. The current status quo of the lengthy treatment duration and poor treatment outcomes associated with MDR/extensively drug-resistant TB, and those with comorbidity of TB with human immunodeficiency virus and noncommunicable diseases in sub-Saharan Africa is unacceptable. The TB drug pipeline remains sparse. New innovations for shortening the duration of therapy and improving treatment outcomes (cure and long-term functional disability due to lung damage) are urgently required...
December 2016: International Journal of Mycobacteriology
Mohammad Delwar Hossain, Jamal Uddin Ahmed, Muhammad Abdur Rahim, A K M Musa, Zafar Ahmed Latif
Tuberculosis (TB) and diabetes mellitus (DM) have synergetic relationship. People with diabetes are 2-3 times at higher risk of getting active TB disease. On the other hand, TB or anti-TB treatment may cause glucose intolerance. The dual disease of DM and TB is more likely to be associated with atypical disease presentation, higher probability of treatment failure and complications. In most of the health-care delivery systems of the world, DM and TB are managed separately by two vertical health-care delivery programs in spite of clear interaction between the two diseases...
November 2016: Indian Journal of Endocrinology and Metabolism
Ji Young Hong, Go Eun Yang, Yousang Ko, Yong Bum Park, Yun Su Sim, Sung Hoon Park, Chang Youl Lee, Ki-Suck Jung, Myung Goo Lee
BACKGROUND: Nutritional assessment is important in patients with pulmonary nontuberculous mycobacterial (PNTM) disease. The therapeutic effect of a cholesterol-rich diet in tuberculosis (TB) patients has been demonstrated, but the role of cholesterol in PNTM disease is unclear. This study evaluated the sequential changes in nutritional markers, including cholesterol, total lymphocyte count and visceral fat volume, according to the PNTM disease course. METHODS: This was an age-, sex- and number of comorbid diseases-matched case-control analysis of 89 patients with PNTM disease and 356 controls, who were participants in a Korean national survey...
October 2016: Journal of Thoracic Disease
Chung-Lin Hung, Po-Lan Su, Chih-Ying Ou
Occupational lung diseases are well recognized risk factors for tuberculosis (TB). However, little research investigated the effect of TB on the clinical course and outcome of occupational lung diseases.We conducted a 13-year observational study of a nationwide cohort to evaluate the risk and prognosis of TB among patients with occupational lung diseases in Taiwan.By using the Taiwan National Health Insurance database, occupational lung diseases cohort was identified according to diagnosis codes from 1998 to 2008 and prospectively monitored until the end of 2010, loss to follow-up, or death...
September 2016: Medicine (Baltimore)
Bibha Marak, Prabhdeep Kaur, Sudha R Rao, Sriram Selvaraju
We did cross-sectional study to estimate the prevalence of tobacco, alcohol use, hypertension and diabetes among tuberculosis (TB) patients in comparison to the non-TB patients in East Garo Hills District, Meghalaya, India. We surveyed 110 TB patients attending outpatient TB clinic and 110 age/sex matched non-TB subjects from the general outpatient department as comparison group. Prevalence of ever smoking was 74.5% and 55.4%; alcohol consumption 31.0% and 22.3%; hypertension 24.5% and 17.3%; diabetes 7.5%, 4...
April 2016: Indian Journal of Tuberculosis
Jun-Jun Yeh, Yu-Chiao Wang, Chia-Hung Kao
PURPOSE: The association between asthma-chronic obstructive pulmonary diseases (COPD) overlap syndrome (ACOS) and tuberculosis (TB) has yet to be studied. METHODS: The newly diagnosed TB patients (age > 20 y) treated from January 2000 to December 2008 were included (ACOS cohort, n = 10 751; non-ACOS cohort, n = 42 966). The non-ACOS cohort involved patients with confirmed absence of ACOS. We calculated incidence rate ratios (IRRs) for TB in the ACOS and non-ACOS cohorts by using poisson regression analysis...
2016: PloS One
Tsai-Ling Liao, Chin-Fu Lin, Yi-Ming Chen, Hung-Jen Liu, Der-Yuan Chen
Increasing evidence indicates that the risk of nontuberculous mycobacteria (NTM) disease is elevated in patients with rheumatoid arthritis (RA). However, the risk factors and outcomes for NTM disease among RA patients remain unclear. We conducted a case-control study and estimated odds ratios (ORs) for RA patients with NTM disease according to comorbidities and anti-rheumatic medications by using conditional logistic regression. Prior tuberculosis history (adjusted OR (aOR) =5.58, p < 0.001), hypertension (aOR = 2...
2016: Scientific Reports
Matthew Bates, Aaron Shibemba, Victor Mudenda, Charles Chimoga, John Tembo, Mwila Kabwe, Moses Chilufya, Michael Hoelscher, Markus Maeurer, Sylvester Sinyangwe, Peter Mwaba, Nathan Kapata, Alimuddin Zumla
BACKGROUND: Autopsy studies are the gold standard for determining cause-of-death and can inform on improved diagnostic strategies and algorithms to improve patient care. We conducted a cross-sectional observational autopsy study to describe the burden of respiratory tract infections in inpatient children who died at the University Teaching Hospital in Lusaka, Zambia. METHODS: Gross pathology was recorded and lung tissue was analysed by histopathology and molecular diagnostics...
July 1, 2016: BMC Medicine
Kamila Romanowski, Edward G Clark, Adeera Levin, Victoria J Cook, James C Johnston
The link between chronic kidney disease (CKD) and tuberculosis (TB) has been known for more than 40 years, but the interaction between these 2 diseases is still poorly understood. Dialysis and renal transplant patients appear to be at a higher risk of TB, in part related to immunosuppression along with socioeconomic, demographic, and comorbid factors. Meanwhile, TB screening and diagnostic test performance is suboptimal in the CKD population, and there is limited evidence to guide protocols. Given the increasing prevalence of CKD in TB endemic areas, a merging of CKD and TB epidemics could have significant public health implications, especially in low- to middle-income countries such as India and China, that are experiencing rapid increases in CKD prevalence and account for more than one-third of global TB prevalence...
July 2016: Kidney International
Adriana Margarit, Sílvia Simó, Librada Rozas, Àngela Deyà-Martínez, Irene Barrabeig, Amadéu Gené, Clàudia Fortuny, Antoni Noguera-Julian
INTRODUCTION: Adolescents may present with adult-type pulmonary tuberculosis (TB), including cavity disease in upper lobes and smear-positive sputum, which involves a significant transmission risk for social and family contacts. PATIENTS AND METHODS: A retrospective (2007-2012) observational study of a case series of TB was conducted in children and adolescents (<18 years) in a paediatric referral centre in Barcelona. Patients aged≤12 and>12 years at diagnosis are compared...
April 11, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
J Paulino, A Martins, M Machado, M Gomes, A R Gaio, R Duarte
BACKGROUND: Tuberculosis (TB) is a major global health problem, and during the last 20 years, industrialised countries have shown similar patterns in TB notifications: decreasing TB incidence in native populations and increasing incidence in foreign-born populations. OBJECTIVES: To characterise risk factors associated with TB among native- and foreign-born TB patients in Portugal and identify barriers to the management of foreign cases. METHODS: Analysis of the data from the national tuberculosis surveillance system and data from an online survey of physicians managing TB cases in the country...
March 2016: International Journal of Tuberculosis and Lung Disease
Ying Wang, Yourong Yang, Hang Li, Yan Liang, Jianyang Liu, Ting Yu, Xueqiong Wu
BACKGROUND: The rapid diagnosis of bacterium-negative pulmonary TB and extra pulmonary TB is a significant problem in clinical practice. METHODS: 466 individuals were prospectively enrolled, 247 patients with TB, 147 with non-tuberculous pulmonary disease, and 65 healthy controls. Whole blood was stimulated in vitro with rCFP10/ESAT6 antigen of Mycobacterium tuberculosis. A chemiluminescence immunoassay was used to detect the stimulated release of interferon-gamma inducible protein 10 (IP-10), and a receiver operating characteristic (ROC) curve was drawn to determine cutoff value for diagnosing TB and to evaluate the diagnostic efficacy of the IP-10 assay...
2016: Clinical Laboratory
Mahteme Haile Workneh, Gunnar Aksel Bjune, Solomon Abebe Yimer
BACKGROUND: There is growing evidence suggesting that diabetes mellitus (DM) affects disease presentation and treatment outcome in tuberculosis (TB) patients. This study aimed at investigating the role of DM on clinical presentations and treatment outcomes among newly diagnosed TB patients. METHODS: A prospective cohort study was conducted in South-Eastern Amhara Region, Ethiopia from September 2013 till March 2015. Study subjects were consecutively recruited from 44 randomly selected health facilities in the study area...
March 21, 2016: Infectious Diseases of Poverty
S M Marks, Y Hirsch-Moverman, K Salcedo, E A Graviss, P Oh, B Seaworth, J Flood, L Armstrong, L Armitige, S Mase
OBJECTIVE: A population-based study of 135 multidrug-resistant tuberculosis (MDR-TB) patients reported to the Centers for Disease Control and Prevention (CDC) during 2005-2007 found 73% were hospitalized. We analyzed factors associated with hospitalization. METHODS: We assessed statistically significant multivariable associations with US in-patient TB diagnosis, frequency of hospitalization, length of hospital stay, and in-patient direct costs to the health care system...
April 2016: International Journal of Tuberculosis and Lung Disease
Rachel Byng-Maddick, Mahdad Noursadeghi
BACKGROUND: The global population is ageing quickly and our understanding of age-related changes in the immune system suggest that the elderly will have less immunological protection from active tuberculosis (TB). DISCUSSION: Ongoing global surveillance of TB notifications shows increasing age of patients with active TB. This effect of age is compounded by changes to clinical manifestations of disease, confounding of diagnostic tests and increased rates of adverse reactions to antimicrobial treatment of TB...
March 11, 2016: BMC Infectious Diseases
Chih-Hao Shen, Chung-Hsing Chou, Feng-Cheng Liu, Te-Yu Lin, Wen-Yen Huang, Yu-Chiao Wang, Chia-Hung Kao
Few studies have investigated the association between tuberculosis (TB) and Parkinson disease (PD). This nationwide, population-based, retrospective cohort study investigated the risk of PD in patients with TB.We selected patients newly diagnosed with TB (International Classification of Diseases, Ninth Revision, Clinical Modification: 011) from 2000 to 2009 in the Taiwan National Health Insurance Database as the TB cohort. The comparison cohort (the non-TB cohort) was frequency matched to the TB cohort at a ratio of 4:1 by sex, age, and the index date...
February 2016: Medicine (Baltimore)
A V Mordyk, L V Puzyreva, T L Batishcheva
AIM: To identify predictors for the poor outcome of infiltrative pulmonary tuberculosis (IPTB). SUBJECTS AND METHODS: The social, epidemiological, and medical risk factors and clinical features of IPTB were assessed in 130 first detected patients. The findings were classified using a cluster analysis and then a variance analysis, followed by the ranking of its results. RESULTS: The primarily diagnosed disseminated destructive process with respiratory and cardiopulmonary failure, excretion of both resistant and multi-resistant pathogenic bacteria had a strong impact on the poor outcome of tuberculosis (TB) in the first detected patients...
2015: Terapevticheskiĭ Arkhiv
W-C Fan, S-M Ou, J-Y Feng, Y-W Hu, C-M Yeh, V Y-F Su, L-Y Hu, S-H Chien, W-J Su, T-J Chen, C-J Liu
BACKGROUND: Previous studies have suggested a close correlation between gastroesophageal reflux disease (GERD) and various respiratory disorders. However, the association between GERD and tuberculosis (TB) remains unexplored. METHODS: Using data retrieved from Taiwan's National Health Insurance Research Database from 2000 to 2009, this longitudinal nationwide cohort study included a total of 63,930 patients with GERD and controls matched by age, sex and comorbidities...
February 2016: International Journal of Tuberculosis and Lung Disease
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