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DOXETACEL TOXICITY

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https://www.readbyqxmd.com/read/19707385/randomized-phase-ii-clinical-trial-of-chemo-immunotherapy-in-advanced-nonsmall-cell-lung-cancer
#1
Eduardo Lasalvia-Prisco, Emilio Garcia-Giralt, Jesús Vázquez, Marta Aghazarian, Eduardo Lasalvia-Galante, Joshemaria Larrañaga, Gonzalo Spera
The purpose of this study was to compare chemotherapy-naive patients with stage IV nonsmall cell lung cancer patients treated with chemotherapy or chemoimmunotherapy. We tested doxetacel plus cisplatinum as chemotherapy protocol. An immunomodulatory adjuvant system was added as chemoimmunotherapy to the previously mentioned protocol. This system contains three well-known and complementary conditioners of protective immune-responses: cyclophosphamide low-dose, granulocyte macrophage-colony stimulant factor and magnesium silicate granuloma...
September 2008: Biologics: Targets & Therapy
https://www.readbyqxmd.com/read/11249048/combination-chemotherapy-with-docetaxel-and-cisplatin-for-locally-advanced-and-metastatic-gastric-cancer
#2
K Ridwelski, T Gebauer, J Fahlke, H Kröning, E Kettner, F Meyer, K Eichelmann, H Lippert
BACKGROUND: Poor treatment results obtained with palliative chemotherapy for advanced gastric cancer indicate the need for new effective and well-tolerated regimens. PATIENTS AND METHODS: Forty-three patients with locally advanced or metastatic gastric cancer were enrolled in a phase II study to evaluate the efficacy and safety of combination chemotherapy with doxetacel 75 mg/m2 and cisplatin 75 mg/m2 given every three weeks. RESULTS: Thirty-nine patients were evaluable for response...
January 2001: Annals of Oncology: Official Journal of the European Society for Medical Oncology
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