Edgardo Pezzetta, Roger Stupp, Abderrahim Zouhair, Louis Guillou, Patrick Taffé, Christian von Briel, Thorsten Krueger, Hans-Beat Ris
OBJECTIVE: Comparison of prospectively treated patients with neoadjuvant cisplatin-based chemotherapy vs radiochemotherapy followed by resection for mediastinoscopically proven stage III N2 non-small cell lung cancer with respect to postoperative morbidity, pathological nodal downstaging, overall and disease-free survival, and site of recurrence. METHODS: Eighty-two patients were enrolled between January 1994 to June 2003, 36 had cisplatin and doxetacel-based chemotherapy (group I) and 46 cisplatin-based radiochemotherapy up to 44 Gy (group II), either as sequential (25 patients) or concomitant (21 patients) treatment...
June 2005: European Journal of Cardio-thoracic Surgery