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https://www.readbyqxmd.com/read/29330596/cognitive-functioning-is-it-all-or-none
#1
Isabel M Introzzi, María M Richard S, Ana Comesaña, Ana García Coni
Under various circumstances, the cognitive system operates in a global manner that is not very precise and barely discriminatory. This form of operating has been described via a general principal that Diamond (Developmental Psychology 45:130-138, 2009) has denominated the All or None Hypothesis. This author has described a set of corollaries derived from this hypothesis that make it possible to verify it in each one of these domains. Although there is evidence of the global and non-discriminate way in which the cognitive system operates in populations of children, to date, there are no studies that have examined whether this mode of operation is also present in populations of adults...
January 12, 2018: Psychological Research
https://www.readbyqxmd.com/read/29217781/benefits-and-pitfalls-of-peg-interferon-%C3%AE-2a-therapy-in-patients-with-myeloproliferative-neoplasm-associated-myelofibrosis-a-french-intergroup-of-myeloproliferative-neoplasms-fim-study
#2
Jean-Christophe Ianotto, Aurélie Chauveau, Françoise Boyer-Perrard, Emmanuel Gyan, Kamel Laribi, Pascale Cony-Makhoul, Jean-Loup Demory, Benoit de Renzis, Christine Dosquet, Jerome Rey, Lydia Roy, Brigitte Dupriez, Laurent Knoops, Laurence Legros, Mohamed Malou, Pascal Hutin, Dana Ranta, Omar Benbrahim, Valérie Ugo, Eric Lippert, Jean-Jacques Kiladjian
We have previously described the safety and efficacy of pegylated interferon-α2a therapy in a cohort of sixty-two patients with myeloproliferative neoplasm-associated myelofibrosis followed in centers affiliated to the French Intergroup of Myeloproliferative neoplasms. In this study, we report their long-term outcomes and correlations with mutational patterns of driver and non-driver mutations analyzed by targeted next generation sequencing. The median age at diagnosis was 66 years-old, the median follow-up since pegylated interferon initiation was 58 months...
December 7, 2017: Haematologica
https://www.readbyqxmd.com/read/29182199/-an-analysis-of-essential-health-research-in-chile
#3
Rodolfo Armas Merino, Adrián Torres Canales
Essential research studies of health problems affecting the majority of the population, aiming at actions that are feasible to be taken, efficiently and effectively implementing there and seeking solutions to unsolved problems. This is a complex process, which requires long lasting participation and coordinated interaction between different relevant sectors, namely the academic world, health policymakers and health-related industries. An analysis of essential health research in Chile is presented, considering factors such as shared efforts between the academic and health care sectors and the role of the Ministry of Health in research promotion...
July 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29179634/azacytidine-in-combination-with-tyrosine-kinase-inhibitors-induced-durable-responses-in-patients-with-advanced-phase-chronic-myelogenous-leukemia
#4
Mathilde Ruggiu, Florence Oberkampf, David Ghez, Pascale Cony-Makhoul, Florence Beckeriche, Isabelle Cano, Anne L Taksin, Omar Benbrahim, Stéphanie Ghez, Hassan Farhat, Sophie Rigaudeau, Noémie de Gunzburg, Diane Lara, Christine Terre, Victoria Raggueneau, Isabel Garcia, Marc Spentchian, Stéphane De Botton, Philippe Rousselot
Although the tyrosine kinase inhibitor (TKI) era has brought great improvement in outcome in chronic myelogenous leukemia (CML), prognosis of accelerated phase or myeloid blast crisis patients or of de novo Philadelphia chromosome-positive acute myeloid leukemia remains poor. We conducted a retrospective study on patients with advanced phase disease treated with a TKI and azacytidine. Sixteen patients were eligible. Median age was 64.9 years, the median number of previous therapies was 2.5 lines, and median follow-up was 23...
November 28, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29134867/the-best-of-leaders-at-the-worst-of-times-medical-scientist-and-war-premier
#5
Nicholas Coni
Professor Juan Negrín López was Prime Minister of the democratically elected left-wing government of Spain for the latter two-and-a-half years of the three-year Civil War which ravaged the country between 1936 and 1939. The side loyal to the government lost, partly because of the generous aid received by their opponents from Germany and Italy, partly because of the Anglo-French agreement, observed by most countries but ignored by Germany and Italy, to outlaw arms supplies to either side, partly because of internal dissent, and partly because of the greater military capability of the enemy...
January 1, 2017: Journal of Medical Biography
https://www.readbyqxmd.com/read/29130368/blocked-vs-interleaved-presentation-and-proactive-interference-in-episodic-memory
#6
Fabio Del Missier, Alessia Sassano, Valentina Coni, Martina Salomonsson, Timo Mäntylä
Although a number of theoretical accounts of proactive interference (PI) in episodic memory have been proposed, existing empirical evidence does not support conclusively a single view yet. In two experiments we tested the predictions of the temporal discrimination theory of PI against alternative accounts by manipulating the presentation schedule of study materials (lists blocked by category vs. interleaved). In line with the temporal discrimination theory, we observed a clear buildup of (and release from) PI in the blocked condition, in which all the lists of the same category were presented sequentially...
November 13, 2017: Memory
https://www.readbyqxmd.com/read/29114245/the-selective-interaction-of-pistacia-lentiscus-oil-vs-human-streptococci-an-old-functional-food-revisited-with-new-tools
#7
Germano Orrù, Cristina Demontis, Antonello Mameli, Enrica Tuveri, Pierpaolo Coni, Giuseppina Pichiri, Ferdinando Coghe, Antonella Rosa, Paola Rossi, Guy D'hallewin
Pistacia lentiscus berry oil (LBO) represents a typical vegetal product of the Mediterranean basin that has been formally used in traditional cuisine for 100s of years. In addition to its interesting alimentary properties, this product could represent an interesting candidate in the field of research on the study of new anti-infective agents. In fact, in Mediterranean countries, lentisk oil still continues to be widely used in folk medicine for oral and skin affections, in particular, acute gingivitis, pediatric skin infections such as impetigo and foot plaques, and biofilm related infections often associated with Streptococcus spp...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29112443/real-time-observation-of-nonadiabatic-bifurcation-dynamics-at-a-conical-intersection
#8
Kyung Chul Woo, Do Hyung Kang, Sang Kyu Kim
Looking into temporal dynamics of the reactive flux that is precisely located at the well-characterized conical intersection has been one of chemists' longstanding goals. We report here real-time nonadiabatic bifurcation dynamics in the S-CH3 bond predissociation of thioanisole (C6H5SCH3) in the first electronically excited state (S1). It is found that two distinct adiabatic and nonadiabatic reaction pathways are activated simultaneously only when the vibronic state near the first conical intersection is optically accessed...
November 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29096695/floral-micromorphology-and-transcriptome-analyses-of-a-fragrant-vandaceous-orchid-vanda-mimi-palmer-for-its-fragrance-production-sites
#9
Conie Toh, Ab Rahim Mohd-Hairul, Nooraini Mohd Ain, Parameswari Namasivayam, Rusea Go, Nur Ashikin Psyquay Abdullah, Meilina Ong Abdullah, Janna Ong Abdullah
BACKGROUND: Vanda Mimi Palmer (VMP) is commercially valuable for its strong fragrance but little is known regarding the fragrance production and emission sites on the flowers. RESULTS: Olfactory perception detected fragrance only from the petals and sepals. Light and Environmental Scanning Electron microscopy analyses on fresh tissues showed distributions of stomata and trichomes concentrated mostly around the edges. These results paralleled the rich starch deposits and intense neutral red stain, indicating strong fragrance and trichomes as potential main fragrance release sites...
November 2, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29083497/iridium-based-multimetallic-porous-hollow-nanocrystals-for-efficient-overall-water-splitting-catalysis
#10
Jianrui Feng, Fan Lv, Weiyu Zhang, Peihao Li, Kai Wang, Chao Yang, Bin Wang, Yong Yang, Jinhui Zhou, Fei Lin, Gui-Chang Wang, Shaojun Guo
The development of active and durable bifunctional electrocatalysts for overall water splitting is mandatory for renewable energy conversion. This study reports a general method for controllable synthesis of a class of IrM (M = Co, Ni, CoNi) multimetallic porous hollow nanocrystals (PHNCs), through etching Ir-based, multimetallic, solid nanocrystals using Fe(3+) ions, as catalysts for boosting overall water splitting. The Ir-based multimetallic PHNCs show transition-metal-dependent bifunctional electrocatalytic activities for both the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) in acidic electrolyte, with IrCo and IrCoNi PHNCs being the best for HER and OER, respectively...
October 30, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29055107/targeting-class-i-histone-deacetylases-by-the-novel-small-molecule-inhibitor-4sc-202-blocks-oncogenic-hedgehog-gli-signaling-and-overcomes-smoothened-inhibitor-resistance
#11
Wolfgang Gruber, Elisabeth Peer, Dominik P Elmer, Christina Sternberg, Suzana Tesanovic, Pedro Del Burgo, Sonia Coni, Gianluca Canettieri, Daniel Neureiter, René Bartz, Hella Kohlhof, Daniel Vitt, Fritz Aberger
Aberrant activation of Hedgehog (HH)/GLI signaling is causally involved in numerous human malignancies, including basal cell carcinoma (BCC) and medulloblastoma. HH pathway antagonists targeting Smoothened (SMO), an essential effector of canonical HH/GLI signaling, show significant clinical success in BCC patients and have recently been approved for the treatment of advanced and metastatic BCC. However, rapid and frequent development of drug resistance to SMO inhibitors (SMOi) together with severe side effects caused by prolonged SMOi treatment call for alternative treatment strategies targeting HH/GLI signaling downstream of SMO...
October 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28950042/in-situ-anti-solvent-approach-towards-novel-hydrangea-like-hco3o4-nc-coni-ldhs-core-shell-superstructures-for-highly-efficient-water-electrolysis
#12
Hao Zhang, Yinlin Tong, Qingyi Lu, Feng Gao
Highly active, durable and cost-effective electrocatalyst for water oxidation is at the center of renewable energy technologies, including water splitting and metal-air batteries. However, the development of oxygen catalysts with high activity at low cost remains a great challenge. Herein, we report an in situ anti-solvent approach for synthesizing ultrathin Co-Ni layered double hydroxide (CoNi-LDH) nanosheets wrapped on hollow Co3O4 nanoparticle-embedded nitrogen-doped carbon (HCo3O4-NC) as a high-performance catalyst for oxygen evolution reaction (OER)...
September 26, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28912534/multisegmented-nanowires-a-step-towards-the-control-of-the-domain-wall-configuration
#13
E Berganza, M Jaafar, C Bran, J A Fernández-Roldán, O Chubykalo-Fesenko, M Vázquez, A Asenjo
Cylindrical nanowires synthesized by controlled electrodeposition constitute excellent strategic candidates to engineer magnetic domain configurations. In this work, multisegmented CoNi/Ni nanowires are synthesized for tailoring a periodic magnetic structure determined by the balance between magnetocrystalline and magnetostatic energies. High-resolution Transmission Electron Microscopy confirms the segmented growth and the sharp transition between layers. Although both CoNi and Ni segments have similar fcc cubic crystal symmetry, their magnetic configuration is quite different as experimentally revealed by Magnetic Force Microscopy (MFM) imaging...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28815757/first-line-treatment-selection-and-early-monitoring-patterns-in-chronic-phase-chronic-myeloid-leukemia-in-routine-clinical-practice-simplicity
#14
MULTICENTER STUDY
Stuart L Goldberg, Jorge E Cortes, Carlo Gambacorti-Passerini, Rüdiger Hehlmann, H Jean Khoury, Mauricette Michallet, Ron L Paquette, Bengt Simonsson, Teresa Zyczynski, Aimee Foreman, Elisabetta Abruzzese, David Andorsky, Aart Beeker, Pascale Cony-Makhoul, Richard Hansen, Elza Lomaia, Eduardo Olavarria, Michael J Mauro
Achieving successful outcomes in chronic phase-chronic myeloid leukemia (CP-CML) requires careful monitoring of cytogenetic/molecular responses (CyR/MR). SIMPLICITY (NCT01244750) is an observational study exploring tyrosine kinase inhibitor use and management patterns in patients with CP-CML receiving first-line imatinib (n = 416), dasatinib (n = 418) or nilotinib (n = 408) in the US and 6 European countries in routine clinical practice. Twelve-month follow-up data of 1242 prospective patients (enrolled October 01 2010-September 02 2015) are reported...
November 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28782788/nanostructured-coo-nio-coni-anodes-with-tunable-morphology-for-high-performance-lithium-ion-batteries
#15
Huan Liu, Xinlu Wang, Hang Xu, Wensheng Yu, Xiangting Dong, Ying Yang, Hongbo Zhang, Jinxian Wang
Nanostructured CoO/NiO/CoNi composites as anode materials for lithium-ion batteries (LIBs) have been successfully prepared by a facile, straightforward, and large-scale dealloying method. The effects of NaOH solution concentration on the structure, morphology and electrochemical performances of the resulting products are studied systematically. These results indicate that the concentration of NaOH solution mainly influences the morphology of the CoO/NiO/CoNi composites. Cyclic voltammetry (CV) and charge-discharge tests have been conducted to assess the lithium storage performances of the CoO/NiO/CoNi anodes obtained from the 5 M NaOH solution...
August 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28708418/vaccines-pesticides-and-narratives-of-exposure-and-evidence
#16
Elena Conis
This essay considers the cultural work performed by two public health narratives - the DDT narrative and the vaccine narrative - as they appeared in popular and professional discourse concerning two recent media events: controversy over an antivaccination film, and the emergence of a Zika global public health emergency. Like all narratives in the history of medicine, the stories historians and others tell about DDT and about vaccines organize a shared past to explain the present. They also point to a hoped-for future...
July 14, 2017: Canadian Bulletin of Medical History, Bulletin Canadien D'histoire de la Médecine
https://www.readbyqxmd.com/read/28662332/magnetic-propulsion-of-recyclable-catalytic-nanocleaners-for-pollutant-degradation
#17
José García-Torres, Albert Serrà, Pietro Tierno, Xavier Alcobé, Elisa Vallés
Electrochemically fabricated magnetic mesoporous CoNi@Pt nanorods are excellent nanomotors with controlled magnetic propulsion and excellent catalytic properties. The core-shell structure allows a double functionality: (i) controlled motion of the nanorods by applying rotating magnetic fields at different frequencies and field strengths and (ii) effective catalytic activity of the platinum shell for reactions involving sodium borohydride. The structure and magnetic properties of the CoNi core are not modified by the presence of the Pt shell...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28582615/iron-induced-activation-of-ordered-mesoporous-nickel-cobalt-oxide-electrocatalyst-for-the-oxygen-evolution-reaction
#18
Xiaohui Deng, Secil Öztürk, Claudia Weidenthaler, Harun Tüysüz
Herein, ordered mesoporous nickel cobalt oxides prepared by the nanocasting route are reported as highly active oxygen evolution reaction (OER) catalysts. By using the ordered mesoporous structure as a model system and afterward elevating the optimal catalysts composition, it is shown that, with a simple electrochemical activation step, the performance of nickel cobalt oxide can be significantly enhanced. The electrochemical impedance spectroscopy results indicated that charge transfer resistance increases for Co3O4 spinel after an activation process, while this value drops for NiO and especially for CoNi mixed oxide significantly, which confirms the improvement of oxygen evolution kinetics...
June 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28429760/corrigendum-selective-targeting-of-hdac1-2-elicits-anticancer-effects-through-gli1-acetylation-in-preclinical-models-of-shh-medulloblastoma
#19
Sonia Coni, Anna Barbara Mancuso, Laura Di Magno, Giulia Sdruscia, Simona Manni, Silvia Maria Serrao, Dante Rotili, Eleonora Spiombi, Francesca Bufalieri, Marialaura Petroni, Monika Kusio-Kobialka, Enrico De Smaele, Elisabetta Ferretti, Carlo Capalbo, Antonello Mai, Pawel Niewiadomski, Isabella Screpanti, Lucia Di Marcotullio, Gianluca Canettieri
No abstract text is available yet for this article.
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28368412/noncanonical-gli1-signaling-promotes-stemness-features-and-in-vivo-growth-in-lung-adenocarcinoma
#20
A Po, M Silvano, E Miele, C Capalbo, A Eramo, V Salvati, M Todaro, Z M Besharat, G Catanzaro, D Cucchi, S Coni, L Di Marcotullio, G Canettieri, A Vacca, G Stassi, E De Smaele, M Tartaglia, I Screpanti, R De Maria, E Ferretti
Aberrant Hedgehog/GLI signaling has been implicated in a diverse spectrum of human cancers, but its role in lung adenocarcinoma (LAC) is still under debate. We show that the downstream effector of the Hedgehog pathway, GLI1, is expressed in 76% of LACs, but in roughly half of these tumors, the canonical pathway activator, Smoothened, is expressed at low levels, possibly owing to epigenetic silencing. In LAC cells including the cancer stem cell compartment, we show that GLI1 is activated noncanonically by MAPK/ERK signaling...
August 10, 2017: Oncogene
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