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Chen Chen, Qinghe Liu, Han Bi, Wenbin You, Wen She, Renchao Che
Multifunctional composite microspheres with a Co20Ni80 core and anatase TiO2 shells (Co20Ni80@TiO2) are synthesized by combining a solvothermal reaction and a calcination process, and include a series of microspheres with different core sizes (100 nm, 500 nm and 1 μm). The mechanism of self-assembly of the primary particles has been effective in both the fabrication of the core and the process of coating. The obtained core-shell particles possess superior monodispersity, size uniformity, and tailored core sizes, and are characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM)...
September 29, 2016: Physical Chemistry Chemical Physics: PCCP
Colin Bonduelle, Hugo Oliveira, Cony Gauche, Jin Huang, Andreas Heise, Sébastien Lecommandoux
Synthetic glycopolypeptides are versatile glycopolymers used to conceive bioinspired nanoassemblies. In this work, novel amphiphilic glycopolypeptides were designed to incorporate lactose or galactan in order to prepare polymeric nanoassemblies with sizes below 50 nm. The bioactivity of the two different outer surface sugar units was evaluated by defining glycan relative binding affinities to human galectins 1 and 3. A specific multivalent effect was found only for polymeric nanoparticles displaying galactan with a significant increase of the binding activity as compared to free glycan in solution...
September 13, 2016: Chemical Communications: Chem Comm
Sandro Orrù, Paola Coni, Andrea Floris, Roberto Littera, Carlo Carcassi, Valeria Sogos, Carla Brancia
TAR deoxyribonucleic acid-binding protein 43 (TDP-43) is a key protein in the pathogenesis of amyoptrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Recent studies suggest that mutations in the TDP-43 coding gene, TARDBP, as well as variations in TDP-43 protein expression levels may disrupt the dynamics of stress granules (SGs). However, it remains unclear whether the pathogenetic effect of the TDP-43 protein is exerted at the cytoplasmic level, through direct participation to SG composition, or at nuclear level, through control of proteins essential to SG assembly...
August 22, 2016: Human Molecular Genetics
Jorge Vivas, Leticia Vivas, Ana Comesaña, Ana García Coni, Agostina Vorano
Semantic feature production norms provide many quantitative measures of different feature and concept variables that are necessary to solve some debates surrounding the nature of the organization, both normal and pathological, of semantic memory. Despite the current existence of norms for different languages, there are still no published norms in Spanish. This article presents a new set of norms collected from 810 participants for 400 living and nonliving concepts among Spanish speakers. These norms consist of empirical collections of features that participants used to describe the concepts...
August 8, 2016: Behavior Research Methods
Marisa de Campos-Santana, Mario Amalfi, Gabriel Castillo, Cony Decock
Species complexes in the poroid Hymenochaetaceae are well documented in the temperate areas. Potential species complexes are less known in tropical areas, however. In the last ten years, four phylogenetically and morphologically closely related species of Phellinus (Hymenochaetaceae) were described from various tropical/subtropical areas viz. P. caribaeo-quercicola, P. gabonensis, P. ellipsoideus, and P. castanopsidis They are characterized by cushion-shaped basidiomata, ventricose, commonly hamate hymenial setae, and broadly ellipsoid, thick-walled, pale yellowish basidiospores...
September 2016: Mycologia
Emma Davis, Katrina Campbell, Glenda Gobe, Carmel Hawley, Nicole Isbel, David W Johnson
BACKGROUND: Although elevated body mass index (BMI) is a predictor of better clinical outcomes in dialysis patients, the evidence in pre-dialysis chronic kidney disease (CKD) is conflicting. Clinical measures of central obesity may be better prognostic indicators, although investigation has been limited. The aim of this study was to assess the predictive value of anthropometric measures for kidney failure progression and mortality in stage 3-4 CKD. METHODS: The study included newly referred stage 3-4 CKD patients at a single centre between 1/1/2008 and 31/12/2010...
2016: BMC Nephrology
Sergio Baldi, Francesco Coni, Giorgio Limerutti, Massimo Baccega, Enrico Ruffini, Paolo Solidoro
Endoscopic treatment of emphysema is supported by different methods, including valves, coils and sealants. The mechanism is mainly related to volume reduction of targeted area. Endobronchial valves (EBV) appear the most studied method. In a multicentre randomised study, placement of unidirectional endobronchial valves resulted in a statistically significant functional improvement in the treated cohort compared to the control. Adverse events, occurring post procedure, included COPD exacerbations, haemoptysis, pneumothorax and pneumonia...
2016: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
Min Cheng, You-Song Ding, En-Qing Gao, Zhicheng Zhang, Qin-Xiang Jia
Seven isomorphous 2D CoNi (0 ≤ x ≤ 1) compounds based on ferromagnetic chains with mixed double [(μ-EO-N3)(μ-N-N-tetrazolate)] (EO = end-on) were synthesized and then structurally and magnetically characterized. They are formulated as [CoNi(L)(N3)(H2O)]·H2O (), (x = 1 (), 0.86 (), 0.74 (), 0.39 (), 0.14 (), 0.10 (), 0 (); L = 3-(5-tetrazole)-N-oxide-pyridine). Magnetic studies revealed that the homo-metallic compounds ( and ) behave as metamagnets, while the hetero-metallic compounds () show interesting composition-dependent slow relaxation due to the synergy effect of Co(II) and Ni(II) ions...
May 10, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Gabriel Etienne, Francoise Huguet, Agnès Guerci-Bresler, Franck E Nicolini, Frédéric Maloisel, Valérie Coiteux, Charles Dauriac, Nathalie Carpentier, Isabelle Bourdeix, Michel Tulliez, Pascale Cony-Makhoul
The availability of tyrosine kinase inhibitors has extended therapeutic options for chronic myeloid leukaemia (CML) patients. Monitoring recommendations and clinical response goals have recently been updated. The objective of this study was to describe the profile of CML patients in chronic phase currently receiving first-line therapy, including treatment, monitoring and response kinetics. A multicentre, cross-sectional, epidemiological survey in unselected chronic phase CML patients in France attending consultations during a one-month period was performed...
July 2016: British Journal of Haematology
Laura Di Magno, Alessio Basile, Sonia Coni, Simona Manni, Giulia Sdruscia, Davide D'Amico, Laura Antonucci, Paola Infante, Enrico De Smaele, Danilo Cucchi, Elisabetta Ferretti, Lucia Di Marcotullio, Isabella Screpanti, Gianluca Canettieri
Hedgehog signaling controls proliferation of cerebellar granule cell precursors (GCPs) and its aberrant activation is a leading cause of Medulloblastoma, the most frequent pediatric brain tumor. We show here that the energy sensor AMPK inhibits Hh signaling by phosphorylating a single residue of human Gli1 that is not conserved in other species. Studies with selective agonists and genetic deletion have revealed that AMPK activation inhibits canonical Hh signaling in human, but not in mouse cells. Indeed we show that AMPK phosphorylates Gli1 at the unique residue Ser408, which is conserved only in primates but not in other species...
February 23, 2016: Oncotarget
L Capasso, M Arpesella, M Gaeta, D D'Alessandro
In recent years, the awareness of the importance of physical activity for human health is growing, as people practicing it; the number of gyms has also substantially increased. Currently, in Italy there is not a consistent regulation regarding hygienic and sanitary requirements of gyms. Several Italian regions issued laws about this topic. The authors analyse the standards required by the Italian Olympic Committee (CONI) and the regional laws, highlighting the numerous issues, among which the possible location of gyms in semi-basements and basements...
November 2015: Annali di Igiene: Medicina Preventiva e di Comunità
Sandy Cepa, Beatrice Koller, Benedikt Christopher Spies, Susanne Stampf, Ralf-Joachim Kohal
OBJECTIVE: To evaluate implant survival, peri-implant tissue conditions, prosthodontic maintenance requirements and patient satisfaction of two differently retained implant-supported mandibular overdentures (IOD) after the 3 years of observation. MATERIALS AND METHODS: Twenty-five patients with edentulous mandibles received two implants each. Twelve patients were randomly selected to receive ball attachments, whereas 13 patients received prefabricated coni. Implant survival, peri-implant parameters (modified Plaque Index, Bleeding on Probing, modified Gingival Index, probing depth and marginal bone loss) and patient satisfaction were assessed...
January 27, 2016: Clinical Oral Implants Research
Delphine Rea, Shanti Ame, Aude Charbonnier, Valérie Coiteux, Pascale Cony-Makhoul, Martine Escoffre-Barbe, Gabriel Etienne, Martine Gardembas, Agnès Guerci-Bresler, Laurence Legros, Franck Nicolini, Michel Tulliez, Eric Hermet, Françoise Huguet, Hyacinthe Johnson-Ansah, Simona Lapusan, Philippe Quittet, Philippe Rousselot, François-Xavier Mahon, Emmanuel Messas
Tyrosine kinase inhibitors targeting the BCR-ABL oncoprotein represent an outstanding progress in chronic myeloid leukemia and long-term progression-free survival has become a reality for a majority of patients. However, tyrosine kinase inhibitors may at best chronicize rather than cure the disease thus current recommendation is to pursue treatment indefinitely. As a consequence, high quality treatment and care must integrate optimal disease control and treatment tolerability. Tyrosine kinase inhibitors have an overall favorable safety profile in clinical practice since most adverse events are mild to moderate in intensity...
February 2016: Bulletin du Cancer
Yang Hou, Shumao Cui, Zhenhai Wen, Xiaoru Guo, Xinliang Feng, Junhong Chen
A novel 3D hybrid electrocatalyst consisting of N-doped CoNi alloy-encapsulated carbon nanotubes (CoNi-NCNT)/N-doped porous carbon nanosheets (NPCNs) is obtained on page 5940 by X. L. Feng, J. H. Chen, and co-workers. The hybrid exhibits excellent electrocatalytic activities for the oxygen reduction and evolution reactions with good stability. The enhanced performance is correlated with the unique morphology and defect structures, high porosity, good conductive networks, and strongly interacting CoNi-NCNT and NPCNs...
November 2015: Small
A Coni, S Mellone, M Colpo, S Bandinelli, L Chiari
The purpose of this study was to investigate the functional decline associated with aging and gender-related differences by means of a set of sensor-based measures. A actor analysis has been performed in order to classify domains of an instrumented Timed Up and Go (TUG) test in a group of community-dwelling elderly people. 239 elderly people were recruited and underwent an instrumented TUG test. Features extracted from TUG trials, were grouped by the factor analysis in six factors with a clear clinical value...
2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Mariella Nieddu, Roberto Mezzanotte, Giuseppina Pichiri, Pier Paolo Coni, Gian Luca Dedola, Maria Luisa Dettori, Michele Pazzola, Giuseppe Massimo Vacca, Renato Robledo
Two clones, Bt1 from Bos taurus and Om1 from Ovis orientalis musimon, were used as probes for hybridization on genomic DNA and on metaphase chromosomes in members of Bovini and Caprini tribes. Bt1 and Om1 are sequences respectively belonging to the 1.715 and 1.714 DNA satellite I families. Southern blots and fluorescence in situ hybridization experiments showed completely coherent results: the Bovini probe Bt1 hybridized only to members of the Bovini tribe and not to members of Caprini. Likewise, the Caprini probe Om1 hybridized only to members of the Caprini tribe and not to members of Bovini...
December 2015: Genetics and Molecular Biology
Franck E Nicolini, Gabriel Etienne, Viviane Dubruille, Lydia Roy, Françoise Huguet, Laurence Legros, Stéphane Giraudier, Valérie Coiteux, Agnès Guerci-Bresler, Pascal Lenain, Pascale Cony-Makhoul, Martine Gardembas, Eric Hermet, Philippe Rousselot, Shanti Amé, Marie-Claude Gagnieu, Christine Pivot, Sandrine Hayette, Veronique Maguer-Satta, Madeleine Etienne, Stéphanie Dulucq, Delphine Rea, François-Xavier Mahon
BACKGROUND: Nilotinib is now recommended for patients with newly diagnosed chronic myeloid leukaemia in chronic phase and leads to important rates of molecular response 4·5 log (MR(4·5)), allowing the prospect of therapy cessation. However, most patients do not reach this criterion and nilotinib is taken for lengthy periods, resulting in chronic or late-onset adverse events. Nilotinib combined with interferon might further increase rates of MR(4·5), avoid late side-effects, and allow therapy cessation...
January 2015: Lancet Haematology
Priscila Missio da Silva, Cony Gauche, Luciano Valdemiro Gonzaga, Ana Carolina Oliveira Costa, Roseane Fett
The aim of this review is to describe the chemical characteristics of compounds present in honey, their stability when heated or stored for long periods of time and the parameters of identity and quality. Therefore, the chemical characteristics of these compounds were examined, such as sugars, proteins, amino acids, enzymes, organic acids, vitamins, minerals, phenolic and volatile compounds present in honey. The stability of these compounds in relation to the chemical reactions that occur by heating or prolonged storage were also discussed, with increased understanding of the behavior regarding the common processing of honey that may compromise its quality...
April 1, 2016: Food Chemistry
Qinghe Liu, Qi Cao, Han Bi, Chongyun Liang, Kaiping Yuan, Wen She, Yongji Yang, Renchao Che
The synthesis of CoNi@SiO2 @TiO2 core-shell and CoNi@Air@TiO2 yolk-shell microspheres is reported for the first time. Owing to the magnetic-dielectric synergistic effect, the obtained CoNi@SiO2 @TiO2 microspheres exhibit outstanding microwave absorption performance with a maximum reflection loss of -58.2 dB and wide bandwidth of 8.1 GHz (8.0-16.1 GHz, < -10 dB).
January 20, 2016: Advanced Materials
A Toma, O Kosmider, S Chevret, J Delaunay, A Stamatoullas, C Rose, O Beyne-Rauzy, A Banos, A Guerci-Bresler, S Wickenhauser, D Caillot, K Laribi, B De Renzis, D Bordessoule, C Gardin, B Slama, L Sanhes, B Gruson, P Cony-Makhoul, B Chouffi, C Salanoubat, R Benramdane, L Legros, E Wattel, G Tertian, K Bouabdallah, F Guilhot, A L Taksin, S Cheze, K Maloum, S Nimuboma, C Soussain, F Isnard, E Gyan, R Petit, J Lejeune, V Sardnal, A Renneville, C Preudhomme, M Fontenay, P Fenaux, F Dreyfus
After failure of erythropoiesis-stimulating agents (ESAs), lenalidomide (LEN) yields red blood cell (RBC) transfusion independence (TI) in 20-30% of lower-risk non-del5q myelodysplastic syndrome (MDS). Several observations suggest an additive effect of ESA and LEN in this situation. We performed a randomized phase III study in 131 RBC transfusion-dependent (TD, median transfusion requirement six RBC units per 8 weeks) lower-risk ESA-refractory non-del5q MDS. Patients received LEN alone, 10 mg per day, 21 days per 4 weeks (L arm) or LEN (same schedule) + erythropoietin (EPO) beta, 60,000 U per week (LE arm)...
April 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
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