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https://www.readbyqxmd.com/read/27910018/fluorescence-in-situ-hybridization-probe-validation-for-clinical-use
#1
Jun Gu, Janice L Smith, Patricia K Dowling
In this chapter, we provide a systematic overview of the published guidelines and validation procedures for fluorescence in situ hybridization (FISH) probes for clinical diagnostic use. FISH probes-which are classified as molecular probes or analyte-specific reagents (ASRs)-have been extensively used in vitro for both clinical diagnosis and research. Most commercially available FISH probes in the United States are strictly regulated by the U.S. Food and Drug Administration (FDA), the Centers for Disease Control and Prevention (CDC), the Centers for Medicare & Medicaid Services (CMS) the Clinical Laboratory Improvement Amendments (CLIA), and the College of American Pathologists (CAP)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27907928/cytomorphological-analysis-of-lymph-node-lesions-in-hiv-positive-patients-with-cd4-count-correlation-a-cross-sectional-study
#2
Sadia Siddiqa Nasser, Rashmi K Patil, Shreekanth K Kittur
OBJECTIVES: To study the cytomorphological spectrum of lymph node lesions in HIV-positive patients and correlate the cytological findings with the CD4 count. STUDY DESIGN: This was a cross-sectional study of 23 months' duration which included 110 HIV-positive cases proved according to the guidelines of the National AIDS Control Organisation. Fine-needle aspiration cytology (FNAC) was done on clinically palpable lymph nodes. Special stains and culture were done wherever necessary...
December 2, 2016: Acta Cytologica
https://www.readbyqxmd.com/read/27906759/development-of-a-disease-based-hernia-program-and-the-impact-on-cost-for-a-hospital-system
#3
David M Krpata, Ivy N Haskins, Steven Rosenblatt, Sharon Grundfest, Ajita Prabhu, Michael J Rosen
OBJECTIVE: The aim of this study was to assess the impact of developing a hernia program on mesh utilization. BACKGROUND: With the ongoing changes in healthcare, the value of all interventions will see increased scrutiny. Hernia mesh can be one of the most costly components of hernia repairs. A disease-based institutional hernia program that defines roles for mesh utilization and measures outcomes has the potential to add significant value to hospital systems. METHODS: In August 2014, a disease-based hernia program was initiated across a hospital system...
November 30, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27898570/are-centers-for-disease-control-and-prevention-guidelines-for-preexposure-prophylaxis-specific-enough-formulation-of-a-personalized-hiv-risk-score-for-pre-exposure-prophylaxis-initiation
#4
Matthew R Beymer, Robert E Weiss, Catherine A Sugar, Linda B Bourque, Gilbert C Gee, Donald E Morisky, Suzanne B Shu, Marjan Javanbakht, Robert K Bolan
BACKGROUND: Preexposure prophylaxis (PrEP) has emerged as a human immunodeficiency virus (HIV) prevention tool for populations at highest risk for HIV infection. Current US Centers for Disease Control and Prevention (CDC) guidelines for identifying PrEP candidates may not be specific enough to identify gay, bisexual, and other men who have sex with men (MSM) at the highest risk for HIV infection. We created an HIV risk score for HIV-negative MSM based on Syndemics Theory to develop a more targeted criterion for assessing PrEP candidacy...
November 28, 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27873754/addressing-the-limitations-of-the-cdc-guideline-for-prescribing-opioids-for-chronic-noncancer-pain
#5
Jason W Busse, David Juurlink, Gordon H Guyatt
No abstract text is available yet for this article.
December 6, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/27861568/appropriateness-of-intrapartum-antibiotic-prophylaxis-to-prevent-neonatal-group-b-streptococcus-disease
#6
Aida Bianco, Elisabetta Larosa, Claudia Pileggi, Maria Pavia
The aims of this study were to describe the adherence to CDC guidelines for intrapartum antibiotic prophylaxis (IAP) and to identify possible factors influencing noncompliance with guidelines. We conducted a retrospective study in Italy. Our cohort included women in whom antenatal Group B Streptococcus (GBS) screening was not performed, was performed, but results were not available at the time of labor or delivery and women who were positive for GBS colonization. The indications for complete execution of IAP according to revised CDC guidelines was evaluated...
2016: PloS One
https://www.readbyqxmd.com/read/27857635/a-review-of-the-centers-for-disease-control-and-prevention-s-guidelines-for-the-clinical-laboratory-diagnosis-of-lyme-disease
#7
REVIEW
Caterina M Miraglia
OBJECTIVE: The purpose of this paper is to review information regarding the current guidelines for the clinical laboratory diagnosis of Lyme disease as set forth by the Centers for Disease Control and Prevention (CDC) to chiropractic physicians and to discuss the clinical utility of this testing. METHODS: The CDC's website was reviewed to determine what their current recommendations are for the clinical laboratory testing of Lyme disease. RESULTS: The CDC's established guidelines recommend the use of a 2-tiered serologic testing algorithm for the evaluation of patients with suspected Lyme disease...
December 2016: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/27798338/dietary-fiber-intake-is-inversely-associated-with-periodontal-disease-among-us-adults
#8
Samara Joy Nielsen, Maria Angelica Trak-Fellermeier, Kaumudi Joshipura, Bruce A Dye
BACKGROUND: Approximately 47% of adults in the United States have periodontal disease. Dietary guidelines recommend a diet providing adequate fiber. Healthier dietary habits, particularly an increased fiber intake, may contribute to periodontal disease prevention. OBJECTIVE: Our objective was to evaluate the relation of dietary fiber intake and its sources with periodontal disease in the US adult population (≥30 y of age). METHODS: Data from 6052 adults participating in NHANES 2009-2012 were used...
October 26, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27787348/budgetary-impact-of-compliance-with-sti-screening-guidelines-in-persons-living-with-hiv
#9
Ellen F Eaton, Kathryn Hudak, Christina A Muzny
INTRODUCTION: The 2015 Centers for Disease Control (CDC) Sexually Transmitted Diseases (STD) Treatment Guidelines recommend annual screening of all persons living with HIV (PLWH) for N. gonorrhoeae, C. trachomatis, and syphilis; annual T. vaginalis screening is recommended for HIV-infected women. The study objective is to evaluate the budgetary impact of sexually transmitted infection (STI) screening. We hypothesized that recommended STI screening is costly and would not be covered in full by insurers...
October 19, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27786538/new-opioid-prescribing-guidelines-released-in-the-us-what-impact-will-they-have-in-the-care-of-older-patients-with-persistent-pain
#10
Fabio Guerriero, M Carrington Reid
To address the dramatic opioid epidemic and related-deaths from overdoses in the US, the Centers for Disease Control and Prevention (CDC) released a Guideline for Prescribing Opioids for Chronic Pain earlier this year. The guideline is designed to support clinicians caring for patients outside the context of active cancer treatment or palliative or end-of-life care. In this editorial, we review specific CDC recommendations that we believe could have positive or negative consequences when providing care to older adults with persistent pain...
October 27, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27780180/endocrinopathies-in-women-during-opioid-therapy-cause-loss-of-androgens-fatigue-listlessness-loss-of-libido-and-quality-of-life-stop-prescribing-opioids-or-follow-the-2016-centers-for-disease-control-and-prevention-cdc-guidelines
#11
https://www.readbyqxmd.com/read/27764082/declines-in-opioid-prescribing-after-a-private-insurer-policy-change-massachusetts-2011-2015
#12
Macarena C García, Anton B Dodek, Tom Kowalski, John Fallon, Scott H Lee, Michael F Iademarco, John Auerbach, Michele K Bohm
Overdose deaths involving opioid pain medications are epidemic in the United States, in part because of high opioid prescribing rates and associated abuse of these drugs (1). In 2014, nearly 2 million U.S. residents either abused or were dependent on prescription opioids (2). In Massachusetts, unintentional opioid-related overdose deaths, including deaths involving heroin, increased 45% from 2012 to 2013.* In 2014, the rate of these deaths reached 20.0 per 100,000, nearly 2.5 times higher than the U.S. rate overall (3,4)...
October 21, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27754000/db-02-2-strict-control-of-hypertension-in-the-frail-elderly-is-it-beneficial-con
#13
Hiromi Rakugi
European guidelines (ESH-ESC2013) for the elderly have discussed well about treatment blood pressure (BP) levels and targeting BP levels. In general, elderly patients with systolic BP (SBP) ≥160 mmHg including individuals older than 80 years in good physical and mental conditions are recommended reducing SBP to between 150 and 140 mmHg. Furthermore, fit elderly patients <80 years old are recommended to consider antihypertensive treatment at SBP values ≥140 mmHg with a target SBP <140 mmHg. On the other hand, frail elderly patients are recommended to leave decisions on antihypertensive therapy to the treating physician, and based on monitoring of the clinical effects of treatment...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27749798/physician-adherence-to-centers-for-disease-control-and-prevention-guidelines-for-sexually-active-adolescents-in-the-pediatric-emergency-setting
#14
Michelle L Pickett, Marlene D Melzer-Lange, Melissa K Miller, Seema Menon, Alexis M Vistocky, Amy L Drendel
OBJECTIVES: There is limited literature about physicians' adherence to 2010 Centers for Disease Control and Prevention (CDC) Sexually Transmitted Diseases Treatment Guidelines specific to specimen collection testing methods in adolescent females in the emergency setting is limited. The objectives are to (1) determine physician adherence to CDC guidelines for specimen collection/testing for chlamydia and gonorrhea, (2) determine physician characteristics associated with guideline adherence, and (3) describe physicians' knowledge of expedited partner therapy (EPT) laws...
October 4, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27733960/awareness-of-the-cdc-heads-up-to-youth-sports-campaign-among-pediatric-sports-coaches-a-pilot-survey-study
#15
Thor S Stead, Vaibhav Rastogi, Vishnumurthy S Hedna, Latha Ganti
OBJECTIVES: This study sought to: 1) estimate the penetrance (in terms of youth coaches being aware of them) of the CDC "Heads Up!" guidelines, 2) determine whether these guidelines changed the coaches' practice, and 3) understand whether these guidelines resulted in a perceived decrease in the number of concussions. METHODS: This was a cross-sectional survey of pediatric sports coaches in the United States designed to assess the impact of the CDC "Heads Up!" GUIDELINES: "Heads Up!" Concussion in Youth Sports is a free, online course available to coaches, parents, and others helping to keep athletes safe from concussions...
August 29, 2016: Curēus
https://www.readbyqxmd.com/read/27711044/evaluation-of-the-management-of-pregnancies-and-infants-at-risk-for-congenital-syphilis-la-r%C3%A3-union-2008-to-2014
#16
M Le Chevalier de Préville, J-L Alessandri, N Traversier, F Cuillier, S Robin, D Ramful
OBJECTIVE: To evaluate the maternal-fetal management and follow-up of infants at risk for congenital syphilis. STUDY DESIGN: Monocentric retrospective cohort study at the Félix Guyon Hospital, Saint-Denis, La Réunion between January 2008 and December 2014. Management of 38 pregnancies (35 women, 39 fetuses) with a positive syphilis serology was evaluated according to the Centers for Disease Control and Prevention (CDC) guidelines. RESULTS: A total of 68% (n=26) of pregnancies were screened before 16 weeks of gestation, and 26% (n=10) had appropriate treatment...
October 6, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27694044/physical-activity-black-carbon-exposure-and-airway-inflammation-in-an-urban-adolescent-cohort
#17
Stephanie Lovinsky-Desir, Kyung Hwa Jung, Andrew G Rundle, Lori A Hoepner, Joshua B Bautista, Frederica P Perera, Steven N Chillrud, Matthew S Perzanowski, Rachel L Miller
OBJECTIVE: Regular physical activity can improve cardiopulmonary health; however, increased respiratory rates and tidal volumes during activity may increase the effective internal dose of air pollution exposure. Our objective was to investigate the impact of black carbon (BC) measured by personal sampler on the relationship between physical activity and fractional exhaled nitric oxide (FeNO), a marker of airway inflammation. We hypothesized that higher personal BC would attenuate the protective effect of physical activity on airway inflammation...
November 2016: Environmental Research
https://www.readbyqxmd.com/read/27663651/conscious-status-predicts-mortality-among-patients-with-isolated-traumatic-brain-injury-in-administrative-data
#18
Hatim A Alsulaim, Blair J Smart, Anthony O Asemota, R Sterling Haring, Joseph K Canner, David T Efron, Elliott R Haut, Eric B Schneider
BACKGROUND: Outcome studies in trauma using administrative data traditionally employ anatomy-based definitions of injury severity; however, physiologic factors, including consciousness, may correlate with outcomes. We examined whether accounting for conscious status in administrative data improved mortality prediction among patients with moderate to severe TBI. METHODS: Patients meeting Centers for Disease Control and Prevention (CDC) guidelines for TBI in the 2006 to 2011 Nationwide Emergency Department Sample were identified...
August 12, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27642911/db-02-2-strict-control-of-hypertension-in-the-frail-elderly-is-it-beneficial-con
#19
Hiromi Rakugi
European guidelines (ESH-ESC2013) for the elderly have discussed well about treatment blood pressure (BP) levels and targeting BP levels. In general, elderly patients with systolic BP (SBP) ≥160 mmHg including individuals older than 80 years in good physical and mental conditions are recommended reducing SBP to between 150 and 140 mmHg. Furthermore, fit elderly patients <80 years old are recommended to consider antihypertensive treatment at SBP values ≥140 mmHg with a target SBP <140 mmHg. On the other hand, frail elderly patients are recommended to leave decisions on antihypertensive therapy to the treating physician, and based on monitoring of the clinical effects of treatment...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27623701/pre-emptive-intrathecal-vancomycin-therapy-reduces-external-ventricular-drain-infection-a-single-centre-retrospective-case-control-study
#20
Richard Z Fu, Durria R Anwar, James T Laban, Eleni C Maratos, Pawanjit S Minhas, Andrew J Martin
OBJECTIVES: External ventricular drain (EVD)-related infection is a significant source of morbidity in neurosurgical patients. Recently, there has been a drive to adopt new catheters with bactericidal properties to reduce infection rates. We propose that the use of standard catheters combined with pre-emptive intrathecal vancomycin (ITV) 10 mg daily provides an effective alternative. DESIGN: Retrospective study of all patients with EVDs between 2010 and 2012, comparing infection rates in those who did and did not receive pre-emptive ITV...
September 14, 2016: British Journal of Neurosurgery
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