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https://www.readbyqxmd.com/read/28098447/the-stories-tryptophans-tell-exploring-protein-dynamics-of-heptosyltransferase-i-from-escherichia-coli
#1
Joy M Cote, Carlos Andres Ramirez-Mondragon, Zarek S Siegel, Daniel Joseph Czyzyk, Jiali Gao, Yuk Yin Sham, Ishita Mukerji, Erika A Taylor
Heptosyltransferase I (HepI) catalyzes the addition of a single L-glycero-β-D-manno-heptose sugar (heptose) onto the membrane incorporated Kdo2-Lipid A as part of the biosynthesis of the core region of lipopolysaccharide (LPS). Gram-negative bacteria with gene knockouts of HepI have reduced virulence with enhanced susceptibility to hydrophobic antibiotics, making design of inhibitors against HepI of interest. Previous studies have shown that HepI protein dynamics are partially rate limiting, and therefore disruption of protein dynamics might provide a new strategy for inhibiting HepI...
January 18, 2017: Biochemistry
https://www.readbyqxmd.com/read/28095614/over-the-scope-clip-closure-for-treatment-of-post-pancreaticogastrostomy-occurring-pancreatic-fistula-a-case-series
#2
Santi Mangiafico, Angelo Caruso, Raffaele Manta, Giuseppe Grande, Helga Bertani, Vincenzo Mirante, Flavia Pigò, Luigi Magnano, Mauro Manno, Rita Conigliaro
BACKGROUND AND AIM: The over-the-scope clip (OTSC) system is a recently developed endoscopic device. In the last few years it has been successfully used for severe bleeding or deep wall lesions, or perforations of the GI tract. We hereby report a series of patients with post pancreaticogastrostomy occuring pancreatic fistula in whom OTSCs were used as endoscopic treatment. METHODS: We prospectively collected data from January 2012 to July 2015 about cases of postoperative pancreatic fistula...
January 17, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28078438/biological-monitoring-of-cobalt-in-hard-metal-factory-workers
#3
Andrea Princivalle, Ivo Iavicoli, Marzia Cerpelloni, Antonia Franceschi, Maurizio Manno, Luigi Perbellini
PURPOSE: The main aim of this study was to investigate the cobalt (Co) concentrations in urine along 4 months and their relationship with Co concentrations in blood and haemoglobin (adducts) in 34 workers from a hard metal manufacturing plant where metallic Co and Co oxide were used. Furthermore, the excretion kinetics of Co was investigated and the half-lives of Co in blood, plasma and urine were calculated along 18 days of non-exposure in the same workers. METHODS: Co was analysed, in all biological samples, by ICP/MS...
January 11, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28069951/calsequestrin-depolymerizes-when-calcium-is-depleted-in-the-sarcoplasmic-reticulum-of-working-muscle
#4
Carlo Manno, Lourdes C Figueroa, Dirk Gillespie, Robert Fitts, ChulHee Kang, Clara Franzini-Armstrong, Eduardo Rios
Calsequestrin, the only known protein with cyclical storage and supply of calcium as main role, is proposed to have other functions, which remain unproven. Voluntary movement and the heart beat require this calcium flow to be massive and fast. How does calsequestrin do it? To bind large amounts of calcium in vitro, calsequestrin must polymerize and then depolymerize to release it. Does this rule apply inside the sarcoplasmic reticulum (SR) of a working cell? We answered using fluorescently tagged calsequestrin expressed in muscles of mice...
January 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28063198/functional-and-structural-studies-on-the-neisseria-gonorrhoeae-gmha-the-first-enzyme-in-the-glycero-manno-heptose-biosynthesis-pathways-demonstrate-a-critical-role-in-lipooligosaccharide-synthesis-and-gonococcal-viability
#5
Igor H Wierzbicki, Ryszard A Zielke, Konstantin V Korotkov, Aleksandra E Sikora
Sedoheptulose-7-phosphate isomerase, GmhA, is the first enzyme in the biosynthesis of nucleotide-activated-glycero-manno-heptoses and an attractive, yet underexploited, target for development of broad-spectrum antibiotics. We demonstrated that GmhA homologs in Neisseria gonorrhoeae and N. meningitidis (hereafter called GmhAGC and GmhANM , respectively) were interchangeable proteins essential for lipooligosaccharide (LOS) synthesis, and their depletion had adverse effects on neisserial viability. In contrast, the Escherichia coli ortholog failed to complement GmhAGC depletion...
January 7, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/27994855/treatment-with-rituximab-in-idiopathic-membranous-nephropathy
#6
Marco Fiorentino, Francesco Tondolo, Francesca Bruno, Barbara Infante, Giuseppe Grandaliano, Loreto Gesualdo, Carlo Manno
BACKGROUND: Rituximab represents a valid therapeutic option to induce remission in patients with primary glomerulonephritis. Despite several studies proving its efficacy in improving outcomes in patients with membranous nephropathy (MN), its role in therapeutic protocols is not yet defined. METHODS: We studied 38 patients with idiopathic MN treated with rituximab (in 13 patients as first-line therapy, in the remaining 25 after conventional immunosuppressive therapy)...
December 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27986835/tannerella-forsythia-strains-display-different-cell-surface-nonulosonic-acids-biosynthetic-pathway-characterization-and-first-insight-into-biological-implications
#7
Valentin Friedrich, Bettina Janesch, Markus Windwarder, Daniel Maresch, Matthias L Braun, Zoë A Megson, Evgeny Vinogradov, Marie-France Goneau, Ashu Sharma, Friedrich Altmann, Paul Messner, Ian C Schoenhofen, Christina Schäffer
Tannerella forsythia is an anaerobic, Gram-negative periodontal pathogen. A unique O-linked oligosaccharide decorates the bacterium's cell surface proteins and was shown to modulate the host immune response. In our study, we investigated the biosynthesis of the nonulosonic acid (NulO) present at the terminal position of this glycan. A bioinformatic analysis of T. forsythia genomes revealed a gene locus for the synthesis of pseudaminic acid (Pse) in the type strain ATCC 43037 while strains FDC 92A2 and UB4 possess a locus for the synthesis of legionaminic acid (Leg) instead...
December 16, 2016: Glycobiology
https://www.readbyqxmd.com/read/27976667/icoh-international-code-of-ethics-for-occupational-health-professionals-historical-fortune-and-future-perspectives-in-italy
#8
Carlo Petyx, Giovanni Costa, Maurizio Manno, Antonio Valenti, Sergio Iavicoli
The Working Group responsible for the Italian translation of the third edition of the International Code of Ethics, appointed by the President of the International Commission on Occupational Health (ICOH), Dr. Jukka Takala, completed last April the revision work. The final text, already available on the ICOH website, has been printed and distributed by the Italian National Institute for Insurance against Accidents at Work (INAIL) at the 79th National Congress of the Italian Society of Occupational Medicine and Industrial Hygiene (SIMLII), in Rome...
December 13, 2016: La Medicina del Lavoro
https://www.readbyqxmd.com/read/27943112/efficacy-and-safety-of-uninterrupted-rivaroxaban-taken-preoperatively-for-radiofrequency-catheter-ablation-of-atrial-fibrillation-compared-to-uninterrupted-warfarin
#9
Susumu Tao, Kenichiro Otomo, Yuichi Ono, Yuki Osaka, Tatsuhiko Hirao, Kenji Koura, Tomoko Manno, Daisuke Ueshima, Shigeo Shimizu, Mitsuaki Isobe, Kenzo Hirao
PURPOSE: Data on uninterrupted rivaroxaban taken preoperatively for radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) is limited. The aim was to evaluate safety and efficacy of rivaroxaban taken in the morning for AF ablation, especially with regard to asymptomatic cerebral emboli (ACE) and anticoagulation parameters. METHODS: We prospectively evaluated 147 consecutive patients who underwent RFCA (mean age 66, 110 patients with paroxysmal AF), 76 of whom were on rivaroxaban, 71 on warfarin...
December 9, 2016: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/27938348/early-antiretroviral-treatment-eart-limits-viral-diversity-over-time-in-a-long-term-hiv-viral-suppressed-perinatally-infected-child
#10
Paolo Palma, Paola Zangari, Claudia Alteri, Hyppolite K Tchidjou, Emma Concetta Manno, Giuseppina Liuzzi, Carlo Federico Perno, Paolo Rossi, Ada Bertoli, Stefania Bernardi
BACKGROUND: HIV genetic diversity implicates major challenges for the control of viral infection by the immune system and for the identification of an effective immunotherapeutic strategy. With the present case report we underline as HIV evolution could be effectively halted by early antiretroviral treatment (eART). Few cases supported this evidence due to the difficulty of performing amplification and sequencing analysis in long-term viral suppressed patients. Here, we reported the case of limited HIV-1 viral evolution over time in a successful early treated child...
December 9, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27852357/a-multifaceted-approach-to-reduction-of-catheter-associated-urinary-tract-infections-in-the-intensive-care-unit-with-an-emphasis-on-stewardship-of-culturing
#11
Katherine M Mullin, Christopher S Kovacs, Cynthia Fatica, Colette Einloth, Elizabeth A Neuner, Jorge A Guzman, Eric Kaiser, Venu Menon, Leticia Castillo, Marc J Popovich, Edward M Manno, Steven M Gordon, Thomas G Fraser
BACKGROUND Catheter-associated urinary tract infections (CAUTIs) are among the most common hospital-acquired infections (HAIs). Reducing CAUTI rates has become a major focus of attention due to increasing public health concerns and reimbursement implications. OBJECTIVE To implement and describe a multifaceted intervention to decrease CAUTIs in our ICUs with an emphasis on indications for obtaining a urine culture. METHODS A project team composed of all critical care disciplines was assembled to address an institutional goal of decreasing CAUTIs...
February 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27825201/-sentieri-renam-integration-of-incidence-mortality-and-hospitalization-general-remarks-and-a-focus-on-mesothelioma
#12
Susanna Conti, Pietro Comba, Valerio Manno, Giada Minelli, Carmela Nicita, Roberto Pasetto, Lucia Fazzo, Amerigo Zona, Caterina Bruno
The integration of current data sources is now a practice widely used in epidemiology, especially in the environmental field. To better describe the health profile of populations residing in proximity to areas characterized by a "strong environmental pressure", the combined use of multiple indicators (i.e., mortality, hospitalization, cancer incidence) is recommended. To choose an indicator is complex, as indicators should be contextualized and they need to be related to the several issues involved in the studied pathology...
September 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27819518/x-ray-induced-mutation-of-bacillus-sp-mr10-for-manno-oligosaccharides-production-from-copra-meal
#13
Siriporn Chaikaew, Apinun Kanpiengjai, Jenjira Intatep, Kridsada Unban, Pairote Wongputtisin, Goro Takata, Chartchai Khanongnuch
The present study demonstrates the effectiveness of X-ray radiation in strain improvement for defective lipase production by Bacillus sp. MR10 for further application in the fermentative production of manno-oligosaccharides (MOS) from agricultural by-product, defatted copra meal (DCM). The mutants obtained were screened based on their defective lipase activity together with their β-mannanase production performance. Among 10 selected mutants, the strain M7 was the highest promising mutant regarding the smallest lipase activity (0...
November 7, 2016: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/27813071/what-goes-up-must-come-down-a-tripartite-dok-3-grb2-ship1-inhibitory-module-limits-bcr-signaling
#14
Michael Reth, Michael R Gold
Properly regulated immunity requires precise integration of activating and inhibitory signals. As for other lymphocytes, B cells express an antigen-specific activating receptor, the B-cell antigen receptor (BCR), and inhibitory receptors (e.g. FcγRIIb) that exercise checkpoint control on B-cell activation. Moreover, following BCR engagement, CD19 recruits proteins that amplify BCR signaling, while CD22 initiates a negative feedback loop by recruiting proteins that inhibit BCR signaling. Initial BCR signaling is mediated by protein tyrosine kinases and lipid kinases; inhibitory receptors directly antagonize the actions of these enzymes by recruiting protein tyrosine phosphatases and lipid phosphatases and positioning them close to actively signaling BCRs...
November 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27755089/expertise-matters
#15
Edward M Manno, William D Freeman, Sarah Livesay, Romergryko G Geocadin, Michel Torbey, Paul Nyquist, Claude Hemphill
No abstract text is available yet for this article.
November 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27752501/raw264-7-cell-activating-glucomannans-extracted-from-rhizome-of-polygonatum-sibiricum
#16
Khamphone Yelithao, Utoomporn Surayot, Ju Hun Lee, SangGuan You
Water-soluble polysaccharides isolated from the rhizome of Polygonatum sibiricum and fractionated using ion-exchange chromatography were investigated to determine their structure and immunostimulating activity. Crude and fractions (F1 and F2) consisted of carbohydrates (85.1~88.3%) with proteins (4.51~11.9%) and uronic acid (1.79~7.47%), and included different levels of mannose (62.3~76.3%), glucose (15.2~20.3%), galactose (4.35~15.3%), and arabinose (4.00~7.65%). The crude contained two peaks with molecular weights (Mw) of 151×10(3) and 31...
September 2016: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/27727030/immunisation-practices-in-centres-caring-for-children-with-perinatally-acquired-hiv-a-call-for-harmonisation
#17
Alasdair Bamford, Emma C Manno, Maria Jose Mellado, Vana Spoulou, Laura Marques, Henriette J Scherpbier, Tim Niehues, Agnieszka Oldakowska, Paolo Rossi, Paolo Palma
BACKGROUND: Current national immunisation schedules differ between countries in terms of vaccine formulation, timing of vaccinations and immunisation programme funding and co-ordination. As a result, some HIV infected paediatric population may be left susceptible to vaccine preventable infections. Vaccines used in healthy population should be subjected to high quality ethical research and be explicitly validated for use in children with special vaccination needs such as those infected with HIV...
October 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27716510/molecular-diversity-of-midbrain-development-in-mouse-human-and-stem-cells
#18
Gioele La Manno, Daniel Gyllborg, Simone Codeluppi, Kaneyasu Nishimura, Carmen Salto, Amit Zeisel, Lars E Borm, Simon R W Stott, Enrique M Toledo, J Carlos Villaescusa, Peter Lönnerberg, Jesper Ryge, Roger A Barker, Ernest Arenas, Sten Linnarsson
Understanding human embryonic ventral midbrain is of major interest for Parkinson's disease. However, the cell types, their gene expression dynamics, and their relationship to commonly used rodent models remain to be defined. We performed single-cell RNA sequencing to examine ventral midbrain development in human and mouse. We found 25 molecularly defined human cell types, including five subtypes of radial glia-like cells and four progenitors. In the mouse, two mature fetal dopaminergic neuron subtypes diversified into five adult classes during postnatal development...
October 6, 2016: Cell
https://www.readbyqxmd.com/read/27716231/display-of-a-%C3%AE-mannanase-and-a-chitosanase-on-the-cell-surface-of-lactobacillus-plantarum-towards-the-development-of-whole-cell-biocatalysts
#19
Hoang-Minh Nguyen, Geir Mathiesen, Elena Maria Stelzer, Mai Lan Pham, Katarzyna Kuczkowska, Alasdair Mackenzie, Jane W Agger, Vincent G H Eijsink, Montarop Yamabhai, Clemens K Peterbauer, Dietmar Haltrich, Thu-Ha Nguyen
BACKGROUND: Lactobacillus plantarum is considered as a potential cell factory because of its GRAS (generally recognized as safe) status and long history of use in food applications. Its possible applications include in situ delivery of proteins to a host, based on its ability to persist at mucosal surfaces of the human intestine, and the production of food-related enzymes. By displaying different enzymes on the surface of L. plantarum cells these could be used as whole-cell biocatalysts for the production of oligosaccharides...
October 4, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27696564/a-novel-glycan-modifies-the-flagellar-filament-proteins-of-the-oral-bacterium-treponema-denticola
#20
Kurni Kurniyati, John F Kelly, Evgeny Vinogradov, Anna Robotham, Youbing Tu, Juyu Wang, Jun Liu, Susan M Logan, Chunhao Li
While protein glycosylation has been reported in several spirochetes including the syphilis bacterium Treponema pallidum and Lyme disease pathogen Borrelia burgdorferi, the pertinent glycan structures and their roles remain uncharacterized. Herein, a novel glycan with an unusual chemical composition and structure in the oral spirochete Treponema denticola, a keystone pathogen of periodontitis was reported. The identified glycan of mass 450.2 Da is composed of a monoacetylated nonulosonic acid (Non) with a novel extended N7 acyl modification, a 2-methoxy-4,5,6-trihydroxy-hexanoyl residue in which the Non has a pseudaminic acid configuration (L-glycero-L-manno) and is β-linked to serine or threonine residues...
January 2017: Molecular Microbiology
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