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https://www.readbyqxmd.com/read/29165958/advanced-practice-nurses-and-end-of-life-care-for-patients-with-progressive-chronic-kidney-disease-and-end-stage-renal-disease
#1
Vicki Montoya
No abstract text is available yet for this article.
May 2017: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/29165819/metastasectomy-following-incomplete-response-to-high-dose-interleukin-2
#2
Tasha Hughes, Joseph Broucek, Gail Iodice, Praveen K Bommareddy, Sanjib Basu, Howard L Kaufman
OBJECTIVE: To evaluate our experience with metastasectomy following partial response or stable disease after treatment with high-dose interleukin-2 (HD IL-2). METHODS: A total of 305 patients with metastatic renal cell carcinoma or melanoma treated with HD IL-2 over a 12-year period were reviewed. Age, objective response, and overall survival data were evaluated using standard RECIST criteria and Kaplan-Meier estimates. RESULTS: The average age was 55...
November 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29165684/can-biomarkers-advance-hiv-research-and-care-in-the-art-era
#3
Amy C Justice, Kristine M Erlandson, Paolo G Miotti, Alan Landay, Peter W Hunt, Russell P Tracy
Despite achieving HIV-1 RNA suppression below levels of detection and, for most, improved CD4 counts, those aging with HIV experience excess low-level inflammation, hypercoagulability, and immune dysfunction (chronic inflammation) compared to demographically and behaviorally similar uninfected individuals. A host of biomarkers that are linked to chronic inflammation are also associated with HIV-associated non-AIDS events including cardiovascular disease, many forms of cancer, liver disease, renal disease, neurocognitive decline, and osteoporosis...
November 20, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29165620/comparative-effectiveness-of-allopurinol-febuxostat-and-benzbromarone-on-renal-function-in-chronic-kidney-disease-patients-with-hyperuricemia-a-13-year-inception-cohort-study
#4
Hsu-Wen Chou, Hsien-Tsai Chiu, Ching-Wei Tsai, I-Wen Ting, Hung-Chieh Yeh, Han-Chun Huang, Chin-Chi Kuo
Background: Direct comparisons of the effectiveness of allopurinol with that of other urate-lowering agents in chronic kidney disease (CKD) populations, as well as guideline recommendations for clinical practice, are lacking. Methods: We constructed a pharmacoepidemiology cohort study by including patients from Taiwan's long-term integrated CKD care program to compare the effectiveness among allopurinol, febuxostat and benzbromarone in reducing the risk of progression to dialysis...
November 17, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29165595/con-the-role-of-diet-for-people-with-advanced-stage-5-ckd
#5
Graham Woodrow
Restriction of dietary protein intake has been used in the management of chronic kidney disease (CKD) for many decades, yet remains controversial, with marked variations in its application in clinical practice. There is extensive literature on the subject, with some expert opinion advocating the use of protein restriction based on the balance of the available evidence. The largest randomized trial of low-protein diets is the Modification of Diet in Renal Disease study. Despite multiple secondary analyses, the essential intention-to-treat analysis failed to demonstrate a benefit in the primary outcome of rate of decline of glomerular filtration rate...
November 17, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29164839/residual-renal-and-cardiovascular-disease-risk-in-conventionally-treated-patients-with-type-2-diabetes-the-potential-of-non-traditional-biomarkers-and-treatments-related-redox-metabolism
#6
Karima Zitouni, Mia Steyn, Kenneth A Earle
Diabetes is a leading cause of chronic kidney disease (CKD) in the developed world. Promoters of the progression of kidney disease include the traditional profile of cardiovascular risk factors. However, the development of CKD and vulnerability to end-stage renal disease (ESRD) is highly variable. Determinants of the susceptibility to ESRD may include non-traditional risk factors such as gene-environment interactions, socio-geographic factors and/or treatment strategies. We review the conflicting clinical relevance of studies implicating pathways related to oxidative stress...
November 21, 2017: Minerva Medica
https://www.readbyqxmd.com/read/29163528/the-role-of-transforming-growth-factor-beta-1-in-the-progression-of-hiv-aids-and-development-of-non-aids-defining-fibrotic-disorders
#7
REVIEW
Annette J Theron, Ronald Anderson, Theresa M Rossouw, Helen C Steel
Even after attainment of sustained viral suppression following implementation of highly active antiretroviral therapy, HIV-infected persons continue to experience persistent, low-grade, systemic inflammation. Among other mechanisms, this appears to result from ongoing microbial translocation from a damaged gastrointestinal tract. This HIV-related chronic inflammatory response is paralleled by counteracting, but only partially effective, biological anti-inflammatory processes. Paradoxically, however, this anti-inflammatory response not only exacerbates immunosuppression but also predisposes for development of non-AIDS-related, non-communicable disorders...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29161709/impact-of-local-and-systemic-factors-on-kidney-dysfunction-in-bardet-biedl-syndrome
#8
Miriam Zacchia, Giovanna Capolongo, Francesco Trepiccione, Vincent Marion
Bardet Biedl syndrome (BBS) is a rare inherited syndromic condition characterized by renal and extra-renal disorders. Renal defect, at either structural or functional level, is one of the cardinal clinical features, and is a major cause of morbidity. However, the pathogenic mechanism underlying its dysfunction remains largely unknown, and to date only symptomatic treatment with no specific therapy is available for these patients. Elucidating aberrant cellular and/or systemic processes that impact kidney function is therefore a prerequisite to develop targeted innovative therapeutic strategies for the BBS patients...
November 21, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29161295/cardiac-and-renal-dysfunction-is-associated-with-progressive-hearing-loss-in-patients-with-fabry-disease
#9
Maria Köping, Wafaa Shehata-Dieler, Mario Cebulla, Kristen Rak, Daniel Oder, Jonas Müntze, Peter Nordbeck, Christoph Wanner, Rudolf Hagen, Sebastian Schraven
BACKGROUND: Fabry disease (FD) is an X-linked recessive hereditary lysosomal storage disorder which results in the accumulation of globotriaosylceramid (Gb3) in tissues of kidney and heart as well as central and peripheral nervous system. Besides prominent renal and cardiac organ involvement, cochlear symptoms like high-frequency hearing loss and tinnitus are frequently found with yet no comprehensive data available in the literature. OBJECTIVE: To examine hearing loss in patients with FD depending on cardiac and renal function...
2017: PloS One
https://www.readbyqxmd.com/read/29160908/connective-tissue-growth-factor-induces-renal-fibrosis-via-epidermal-growth-factor-receptor-activation
#10
Sandra Rayego-Mateos, José Luis Morgado-Pascual, Raúl R Rodrigues-Diez, Raquel Rodrigues-Diez, Lucas Falke, Sergio Mezzano, Alberto Ortiz, Jesús Egido, Roel Goldschmeding, Marta Ruiz-Ortega
Connective tissue growth factor (CCN2/CTGF) is a matricellular protein overexpressed in progressive human renal diseases, mainly in fibrotic areas. In vitro studies have demonstrated that CCN2 regulates production of extracellular matrix (ECM) proteins and epithelial mesenchymal transition (EMT), and therefore could contribute to renal fibrosis. CCN2 blockade ameliorates experimental renal damage, including diminution of ECM accumulation. We have described that CCN2 and its C-terminal degradation product CCN2(IV), bind to epidermal growth factor receptor (EGFR) to modulate renal inflammation...
November 21, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/29159875/renal-hypoxia-in-kidney-disease-cause-or-consequence
#11
REVIEW
Connie P C Ow, Jennifer P Ngo, Md Mahbub Ullah, Lucinda M Hilliard, Roger G Evans
Tissue hypoxia has been proposed as an important factor in the pathophysiology of both chronic kidney disease and acute kidney injury, initiating and propagating a vicious cycle of tubular injury, vascular rarefaction, and fibrosis and thus exacerbation of hypoxia. Here, we critically evaluate this proposition by systematically reviewing the literature relevant to the following six questions: (1) Is kidney disease always associated with tissue hypoxia? (2) Does tissue hypoxia drive signaling cascades that lead to tissue damage and dysfunction? (3) Does tissue hypoxia per se lead to kidney disease? (4) Does tissue hypoxia precede pathology? (5) Does tissue hypoxia co-localize with pathology? (6) Does prevention of tissue hypoxia prevent kidney disease? We conclude that tissue hypoxia is a common feature of both acute kidney injury and chronic kidney disease...
November 21, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/29159527/melatonin-ameliorates-intrarenal-renin-angiotensin-system-in-a-5-6-nephrectomy-rat-model
#12
Sayaka Ishigaki, Naro Ohashi, Takashi Matsuyama, Shinsuke Isobe, Naoko Tsuji, Takamasa Iwakura, Tomoyuki Fujikura, Takayuki Tsuji, Akihiko Kato, Hiroaki Miyajima, Hideo Yasuda
BACKGROUND: Activation of the intrarenal renin-angiotensin system (RAS) plays a critical role in the pathophysiology of chronic kidney disease (CKD) and hypertension. It has been reported that reactive oxygen species (ROS) are important components of intrarenal RAS activation. Melatonin is recognized as a powerful antioxidant, and we recently reported that impaired nighttime melatonin secretion correlates negatively with urinary angiotensinogen excretion, the surrogate marker of intrarenal RAS activity in patients with CKD...
November 20, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29158549/hypoxia-inducible-factor-1%C3%AE-mediates-the-profibrotic-effect-of-albumin-in-renal-tubular-cells
#13
Junping Hu, Weili Wang, Fan Zhang, Pin-Lan Li, Krishna M Boini, Fan Yi, Ningjun Li
Proteinuria is closely associated with the progression of chronic kidney diseases (CKD) by producing renal tubulointerstitial fibrosis. Over-activation of hypoxia inducible factor (HIF)-1α has been implicated in the progression of CKD. The present study tested the hypothesis that HIF-1α mediates albumin-induced profibrotic effect in cultured renal proximal tubular cells. Incubation of the cells with albumin (40 μg/ml) for 72 hrs significantly increased the protein levels of HIF-1α, tissue inhibitor of metalloproteinase (TIMP)-1 and collagen-I, which were blocked by HIF-1α shRNA...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29158085/generation-of-branching-ureteric-bud-tissues-from-human-pluripotent-stem-cells
#14
Shin-Ichi Mae, Makoto Ryosaka, Taro Toyoda, Kyoko Matsuse, Yoichi Oshima, Hiraku Tsujimoto, Shiori Okumura, Aya Shibasaki, Kenji Osafune
Recent progress in kidney regeneration research is noteworthy. However, the selective and robust differentiation of the ureteric bud (UB), an embryonic renal progenitor, from human pluripotent stem cells (hPSCs) remains to be established. The present study aimed to establish a robust induction method for branching UB tissue from hPSCs towards the creation of renal disease models. Here, we found that anterior intermediate mesoderm (IM) differentiates from anterior primitive streak, which allowed us to successfully develop an efficient two-dimensional differentiation method of hPSCs into Wolffian duct (WD) cells...
November 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29157100/imbalanced-plasma-ace-and-ace2-level-in-the-uremic-patients-with-cardiovascular-diseases-and-its-change-during-a-single-hemodialysis-session
#15
Chung-Wei Yang, Li-Che Lu, Chia-Chu Chang, Ching-Chang Cho, Wen-Yeh Hsieh, Chin-Hung Tsai, Yi-Chang Lin, Chih-Sheng Lin
BACKGROUND: The renin-angiotensin system (RAS) has significant influences on heart and renal disease progression. Angiotensin converting enzyme (ACE) and angiotensin converting enzyme II (ACE2) are major peptidases of RAS components and play counteracting functions through angiotensin II (Ang II)/ATIR and angiotensin-(1-7) (Ang-(1-7))/Mas axis, respectively. METHODS: There were 360 uremic patients on regular hemodialysis (HD) treatment (inclusive of 119 HD patients with cardiovascular diseases (CVD) and 241 HD patients without CVD and 50 healthy subjects were enrolled in this study...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/29156724/lncrna-pvt1-and-its-splicing-variant-function-as-competing-endogenous-rna-to-regulate-clear-cell-renal-cell-carcinoma-progression
#16
Tao Yang, Hui Zhou, Peijun Liu, Libin Yan, Weimin Yao, Ke Chen, Jin Zeng, Heng Li, Junhui Hu, Hua Xu, Zhangqun Ye
Long non-coding RNAs (lncRNAs) exert critical regulatory roles in the development and progression of several cancers. Plasmacytoma variant translocation 1 (PVT1), an lncRNA, was shown to be upregulated in clear cell renal cell carcinoma (ccRCC) in our study, while Kaplan-Meier curve and Cox regression analysis showed that high expression of PVT1 was associated with poor overall survival (OS) and disease free survival (DFS) in ccRCC patients. In vitro experiments revealed that PVT1 promoted renal cancer cell proliferation, migration, and invasion, while in vivo studies confirmed its oncogenic roles in ccRCC...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29155790/a-mouse-5-6th-nephrectomy-model-that-induces-experimental-uremic-cardiomyopathy
#17
Xiaoliang Wang, Muhammad A Chaudhry, Ying Nie, Zijian Xie, Joseph I Shapiro, Jiang Liu
Chronic kidney disease (CKD) is a great risk factor for cardiovascular disease events and mortality, and progressively develops to the clinical phenotype called "uremic cardiomyopathy". We describe here an experimental CKD mouse model, named 5/6(th) partial nephrectomy (PNx) with pole ligation, which developed uremic cardiomyopathy at four weeks post-surgery. This PNx model was performed by a two-step surgery. In step-one surgery, both poles of the left kidney were ligated. In step-two surgery, which was performed 7 days after the step-one surgery, the right kidney was removed...
November 7, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155495/addressing-the-burden-of-dialysis-around-the-world-a-summary-of-the-roundtable-discussion-on-dialysis-economics-at-the-first-international-congress-of-chinese-nephrologists-2015
#18
REVIEW
Philip Kam-Tao Li, Sing Leung Lui, Jack Kit-Chung Ng, Guan Yan Cai, Christopher T Chan, Hung Chun Chen, Alfred K Cheung, Koon Shing Choi, Hui Lin Choong, Stanley L Fan, Loke Meng Ong, Linda Wai Ling Yu, Xue Qing Yu
To address the issue of heavy dialysis burden due to the rising prevalence of end-stage renal disease around the world, a roundtable discussion on the sustainability of managing dialysis burden around the world was held in Hong Kong during the First International Congress of Chinese Nephrologists in December 2015. The roundtable discussion was attended by experts from Hong Kong, China, Canada, England, Malaysia, Singapore, Taiwan and United States. Potential solutions to cope with the heavy burden on dialysis include the prevention and retardation of the progression of CKD; wider use of home-based dialysis therapy, particularly PD; promotion of kidney transplantation; and the use of renal palliative care service...
December 2017: Nephrology
https://www.readbyqxmd.com/read/29154985/adolescent-hydrocele-carrying-a-surprise-a-case-of-papillary-cystadenoma-of-the-epididymis
#19
A Soria Gondek, V Julià Masip, C Jou Muñoz, H Salvador Hernández, C Rovira Zurriaga, X Tarrado Castellarnau
Papillary cystadenoma of the epididymis (PCE) is a rare benign epithelial tumor remarkable for its association with Von Hippel-Lindau disease (VHLD). A 12-year-old male consulted for a progressive enlargement of the left testicle. At time of surgery, the whole epididymis was enlarged. Pathological diagnosis was PCE with a focus of borderline malignancy. Scrotal left epididymectomy was performed. VHLD screening was negative. No relapse has been detected two years later. In case of atypical clinical examination of a hydrocele, unusual presentations such as PCE should be considered...
November 15, 2017: Urology
https://www.readbyqxmd.com/read/29154443/long-term-outcomes-of-patients-with-type-2-diabetes-attending-a-multidisciplinary-diabetes-kidney-disease-clinic
#20
Serena Low, Su Chi Lim, Jiexun Wang, Lee Ying Yeoh, Yan Lun Liu, Eng Kuang Lim, Yan Li Shao, Winnie Chui, Sharon Fun, Chin Lian Chua, Tavintharan Subramaniam, Chee Fang Sum
BACKGROUND: The best model of care to retard diabetic kidney disease (DKD) in the clinic is under-unexplored. We investigated the long-term renal outcomes of a joint endocrinologist-nephrologist clinic. METHODS: This was a nested case-control study derived from a cohort of patients with type 2 diabetes mellitus (T2DM) seen prospectively at a secondary care Diabetes Centre (DC). Cases ("DKD clinic group") are patients seen at the CKD clinic after being referred by physicians in DC for management of DKD...
November 20, 2017: Journal of Diabetes
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