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cholinergic anti inflammatory pathway

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https://www.readbyqxmd.com/read/27927089/an-evaluation-of-the-anti-inflammatory-antipyretic-and-analgesic-effects-of-hydroethanol-leaf-extract-of-albizia-zygia-in-animal-models
#1
Wonder Kofi Mensah Abotsi, Stanley Benjamin Lamptey, Stephen Afrane, Eric Boakye-Gyasi, Ruth Uwa Umoh, Eric Woode
CONTEXT: The leaves of Albizia zygia (DC.) J.F. Macbr. (Leguminosae-Mimosoideae) are used in Ghanaian traditional medicine for the treatment of pain, inflammatory disorders and fever (including malaria). OBJECTIVES: The present study evaluated the anti-inflammatory, antipyretic and analgesic effects of the hydroethanol leaf extract of Albizia zygia (AZE) in animal models. MATERIALS AND METHODS: The anti-inflammatory and antipyretic effects of AZE were examined in the carrageenan-induced foot oedema model and the baker's yeast-induced pyrexia test respectively...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27923376/immunomodulation-after-ischemic-stroke-potential-mechanisms-and-implications-for-therapy
#2
REVIEW
Cynthia Santos Samary, Paolo Pelosi, Pedro Leme Silva, Patricia Rieken Macedo Rocco
Brain injuries are often associated with intensive care admissions, and carry high morbidity and mortality rates. Ischemic stroke is one of the most frequent causes of injury to the central nervous system. It is now increasingly clear that human stroke causes multi-organ systemic disease. Brain inflammation may lead to opposing local and systemic effects. Suppression of systemic immunity by the nervous system could protect the brain from additional inflammatory damage; however, it may increase the susceptibility to infection...
December 7, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27864661/molecular-anti-inflammatory-mechanisms-of-retinoids-and-carotenoids-in-alzheimer-s-disease-a-review-of-current-evidence
#3
REVIEW
Niyaz Mohammadzadeh Honarvar, Ahmad Saedisomeolia, Mina Abdolahi, Amir Shayeganrad, Gholamreza Taheri Sangsari, Babak Hassanzadeh Rad, Gerald Muench
Alzheimer's disease (AD) is considered as one of the most prevalent neurodegenerative disorders characterized by progressive loss of mental function and ability to learn. AD is a multifactorial disorder. Various hypotheses are suggested for the pathophysiology of AD including "Aβ hypothesis," "tau hypothesis," and "cholinergic hypothesis." Recently, it has been demonstrated that neuroinflammation is involved in the pathogenesis of AD. Neuroinflammation causes synaptic dysfunction and neuronal death within the brain...
November 18, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27790217/cholinergic-stimulation-prevents-the-development-of-autoimmune-diabetes-evidence-for-the-modulation-of-th17-effector-cells-via-an-ifn%C3%AE-dependent-mechanism
#4
Junu A George, Ghada Bashir, Mohammed M Qureshi, Yassir A Mohamed, Jamil Azzi, Basel K Al-Ramadi, Maria J Fernández-Cabezudo
Type I diabetes (T1D) results from T cell-mediated damage of pancreatic β-cells and loss of insulin production. The cholinergic anti-inflammatory pathway represents a physiological link connecting the central nervous and immune systems via vagus nerve, and functions to control the release of proinflammatory cytokines. Using the multiple low-dose streptozotocin (MLD-STZ) model to induce experimental autoimmune diabetes, we investigated the potential of regulating the development of hyperglycemia through administration of paraoxon, a highly specific acetylcholinesterase inhibitor (AChEI)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27753973/os-11-06-the-effect-of-vagus-nerve-stimulation-on-arterial-hypertension-using-active-implantable-device
#5
Sekib Sokolovic, Samir Mehmedagic
OBJECTIVE: The goal of this paper was to present the effects of the vagus nerve stimulation (VNS) on a blood pressure (BP) and heart rate (HR) in arterial hypertension patient. DESIGN AND METHOD: The pilot study (SPM-005) was designed to evaluate the eficiancy and safety profile of the neurostimulation of the cholinergic anti-inflammatory pathways using the active implantable device for the vagus nerve stimulation in rheumatoid arthritis patient. We investigated the VNS on the BP and HR in 68 years old female patient with a long-standing arterial hypertension and the lisinopril and hydrochlorothiazide in a therapy...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27752155/-nicotine-alleviates-the-liver-inflammation-of-non-alcoholic-steatohepatitis-induced-by-high-fat-and-high-fructose-in-mice
#6
X M Chen, F Q Li, S Yan, X C Wu, C L Tang
OBJECTIVE: To investigate the anti-inflammation effects by activation of the cholinergic anti-inflammatory pathway and its mechanisms in non-alcoholic steatohepatitis (NASH) model mice. METHODS: 6-week-old male C57BL/6J (B6) mice were randomly divided into four groups: the first group was normal mice, injected with saline; the second group was normal mice, injected with nicotine; the third group was NASH model mice, injected with saline; the fourth group was NASH model mice, injected with nicotine...
October 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27681882/immunomodulatory-effects-of-nicotine-on-interleukin-1%C3%AE-activated-human-astrocytes-and-the-role-of-cyclooxygenase-2-in-the-underlying-mechanism
#7
Priya Revathikumar, Filip Bergqvist, Srividya Gopalakrishnan, Marina Korotkova, Per-Johan Jakobsson, Jon Lampa, Erwan Le Maître
BACKGROUND: The cholinergic anti-inflammatory pathway (CAP) primarily functions through acetylcholine (ACh)-alpha7 nicotinic acetylcholine receptor (α7nAChR) interaction on macrophages to control peripheral inflammation. Interestingly, ACh can also bind α7nAChRs on microglia resulting in neuroprotective effects. However, ACh effects on astrocytes remain elusive. Here, we investigated the effects of nicotine, an ACh receptor agonist, on the cytokine and cholinesterase production of immunocompetent human astrocytes stimulated with interleukin 1β (IL-1β) in vitro...
September 29, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27647951/inflammatory-mechanisms-associated-with-skeletal-muscle-sequelae-after-stroke-role-of-physical-exercise
#8
Hélio José Coelho Junior, Bruno Bavaresco Gambassi, Tiego Aparecido Diniz, Isabela Maia da Cruz Fernandes, Érico Chagas Caperuto, Marco Carlos Uchida, Fabio Santos Lira, Bruno Rodrigues
Inflammatory markers are increased systematically and locally (e.g., skeletal muscle) in stroke patients. Besides being associated with cardiovascular risk factors, proinflammatory cytokines seem to play a key role in muscle atrophy by regulating the pathways involved in this condition. As such, they may cause severe decrease in muscle strength and power, as well as impairment in cardiorespiratory fitness. On the other hand, physical exercise (PE) has been widely suggested as a powerful tool for treating stroke patients, since PE is able to regenerate, even if partially, physical and cognitive functions...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27643370/os-11-06-the-effect-of-vagus-nerve-stimulation-on-arterial-hypertension-using-active-implantable-device
#9
Sekib Sokolovic, Samir Mehmedagic
OBJECTIVE: The goal of this paper was to present the effects of the vagus nerve stimulation (VNS) on a blood pressure (BP) and heart rate (HR) in arterial hypertension patient. DESIGN AND METHOD: The pilot study (SPM-005) was designed to evaluate the eficiancy and safety profile of the neurostimulation of the cholinergic anti-inflammatory pathways using the active implantable device for the vagus nerve stimulation in rheumatoid arthritis patient. We investigated the VNS on the BP and HR in 68 years old female patient with a long-standing arterial hypertension and the lisinopril and hydrochlorothiazide in a therapy...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27594837/curcumin-attenuates-beta-amyloid-induced-neuroinflammation-via-activation-of-peroxisome-proliferator-activated-receptor-gamma-function-in-a-rat-model-of-alzheimer-s-disease
#10
Zun-Jing Liu, Zhong-Hao Li, Lei Liu, Wen-Xiong Tang, Yu Wang, Ming-Rui Dong, Cheng Xiao
Neuroinflammation is known to have a pivotal role in the pathogenesis of Alzheimer's disease (AD), and curcumin has been reported to have therapeutical effects on AD because of its anti-inflammatory effects. Curcumin is not only a potent PPARγ agonist, but also has neuroprotective effects on cerebral ischemic injury. However, whether PPARγ activated by curcumin is responsible for the anti-neuroinflammation and neuroprotection on AD remains unclear, and needs to be further investigated. Here, using both APP/PS1 transgenic mice and beta-amyloid-induced neuroinflammation in mixed neuronal/glial cultures, we showed that curcumin significantly alleviated spatial memory deficits in APP/PS1 mice and promoted cholinergic neuronal function in vivo and in vitro...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27588385/pharmacological-profile-of-dexketoprofen-in-orofacial-pain
#11
Hugo F Miranda, Fernando Sierralta, Nicolás Aranda, Viviana Noriega, Juan Carlos Prieto
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) may act through others mechanisms, in addition to inhibition of prostaglandin synthesis. These includes cholinergic, NO, serotonergic and opioids pathways. METHODS: The aim of this work was to evaluate the effect of systemic action of (S)-+-ketoprofen (dexketoprofen, DEX) on pain behaviors using the orofacial formalin test in mice and the potential involvement of cholinergic, NO, serotonergic and opioids pathways...
June 25, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27573666/role-of-the-%C3%AE-7-nicotinic-acetylcholine-receptor-and-ric-3-in-the-cholinergic-anti-inflammatory-pathway
#12
Millet Treinin, Roger L Papke, Eran Nizri, Yael Ben-David, Tehila Mizrachi, Talma Brenner
The nicotinic acetylcholine receptor (nAChR) gene family encodes for subunits of acetylcholine gated ion channels. These receptors are expressed widely and have many functions: They mediate excitation at neuro-muscular junctions. In the central nervous system nAChRs have been implicated in memory, cognition, and addiction. And in non-excitatory cells they regulate differentiation, proliferation and inflammatory responses. The CHRNA7 gene encodes for the a7 nAChR subunit that assembles into a homomeric receptor having unusual properties...
August 29, 2016: Central Nervous System Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27542331/neuro-immune-interactions-in-the-cholinergic-anti-inflammatory-reflex
#13
REVIEW
Colin Reardon
Communication between the nervous and immune systems can significantly alter immune cell function in a number of inflammatory diseases. Elegant studies have defined a basic functional circuit in a "cholinergic anti-inflammatory pathway" that highlights a unique role for the vagus nerve, and has brought about a resurgence in the field of neuro-immunology. This research has further identified that in addition to tonic signals that can restrain immune cell activation; the anti-inflammatory reflex arc is amiable to targeted stimulation as a therapeutic modality...
October 2016: Immunology Letters
https://www.readbyqxmd.com/read/27524473/reduced-expression-of-vacht-increases-renal-fibrosis
#14
Reinaldo Correia Silva, Fernanda Fernandes Terra, Yuri Felipe Guise, Marco Antônio Máximo Prado, Vânia Ferreira Prado, Meire Ioshie Hiyane, Denise Maria Avancini Costa Malheiros, Carla Maximo Prado, Niels Olsen Saraiva Camara, Tarcio Teodoro Braga
Chronic kidney disease (CKD) is associated with several other long-lasting conditions such as diabetes and cardiovascular diseases and it is a significant contributor to mortality worldwide. Obstructive kidney disease is one of the leading causes of CKD in children and may result from a wide variety of pathologic processes. Recent studies have shown that α7 nicotinic acetylcholine receptor (α7 nAChR) activation in the cholinergic anti-inflammatory pathway reduces production of inflammatory mediators and consequently prevents tissue injury and death...
September 2016: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/27521104/caping-inflammation-and-acute-kidney-injury
#15
Tsuyoshi Inoue, Diane L Rosin, Mark D Okusa
The cholinergic anti-inflammatory pathway has been shown to modulate inflammation in disease models such as rheumatoid arthritis and inflammatory bowel disease. A recent study demonstrated a protective effect of vagus nerve stimulation with activation of the cholinergic anti-inflammatory pathway in the ischemia reperfusion model of acute kidney injury.
September 2016: Kidney International
https://www.readbyqxmd.com/read/27514477/acetylcholine-producing-t-cells-in-the-intestine-affect-antimicrobial-peptide-expression-and-microbial-diversity
#16
Shobhit Dhawan, Giada De Palma, Rose A Willemze, Francisca Hilbers, Caroline Verseijden, Misha Luyer, Sabine Nuding, Jan Wehkamp, Yuri Souwer, Esther C de Jong, Jurgen Seppen, Rene Mjgj van den Wijngaard, Sven Wehner, Elena F Verdu, Premysl Bercik, Wouter J de Jonge
The cholinergic anti-inflammatory pathway reduces systemic TNF via acetylcholine producing memory T-cells in the spleen. These choline acetyltransferase (ChAT) expressing T-cells are also found in the intestine, where their function is unclear. We aimed to characterize these cells in mouse and human intestine and delineate their function. We made use of the ChAT-eGFP reporter mice. CD4Cre mice were crossed to ChATfl/fl mice to achieve specific deletion of ChAT in CD4+ T-cells. We observed that the majority of ChAT expressing T-cells in the human and mouse intestine have characteristics of Th17 cells, and co-express IL17A, IL22 and RORC...
August 11, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27507101/novel-ligands-of-choline-acetyltransferase-designed-by-in-silico-molecular-docking-hologram-qsar-and-lead-optimization
#17
Rajnish Kumar, Bengt Långström, Taher Darreh-Shori
Recent reports have brought back the acetylcholine synthesizing enzyme, choline acetyltransferase in the mainstream research in dementia and the cholinergic anti-inflammatory pathway. Here we report, a specific strategy for the design of novel ChAT ligands based on molecular docking, Hologram Quantitative Structure Activity Relationship (HQSAR) and lead optimization. Molecular docking was performed on a series of ChAT inhibitors to decipher the molecular fingerprint of their interaction with the active site of ChAT...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27464633/-advances-in-the-research-of-effects-of-cholinergic-anti-inflammatory-pathway-on-vital-organ-function-and-its-mechanism
#18
X H Li, Y M Yao
Serious major burns, trauma and surgical stress can easily develop into sepsis, and further result in septic shock or even multiple organ dysfunction syndrome (MODS). The mechanism of MODS is complicated, including excessive inflammation, immune dysfunction, coagulation disorder, and ischemia-reperfusion injury. Recent studies have demonstrated that the nervous system could significantly and quickly suppress systemic inflammatory response via the vagus nerve, which might improve multiple organ damage following acute injury...
July 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27389368/arctigenin-confers-neuroprotection-against-mechanical-trauma-injury-in-human-neuroblastoma-sh-sy5y-cells-by-regulating-mirna-16-and-mirna-199a-expression-to-alleviate-inflammation
#19
Jie Song, Na Li, Yang Xia, Zhong Gao, Sa-Feng Zou, Yu-Hui Yan, Shao-Heng Li, Yue Wang, Ya-Kun Meng, Jing-Xian Yang, Ting-Guo Kang
Mechanical trauma injury is a severe insult to neural cells. Subsequent secondary injury involves the release of inflammatory factors that have dramatic consequences for undamaged cells, leading to normal cell death after the initial injury. The present study investigated the capacity for arctigenin (ARC) to prevent secondary effects and evaluated the mechanism underlying the action of microRNA (miRNA)-199a and miRNA-16 in a mechanical trauma injury (MTI) model using SH-SY5Y cells in vitro. SH-SY5Y cells are often applied to in vitro models of neuronal function and differentiation...
September 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27377300/the-splanchnic-anti-inflammatory-pathway-could-it-be-the-efferent-arm-of-the-inflammatory-reflex
#20
D Martelli, D G S Farmer, S T Yao
What is the topic of this review? We review the current literature on the neural reflex termed the 'inflammatory reflex' that inhibits an excessive release of inflammatory mediators in response to an immune challenge. What advances does it highlight? The original model proposed that the inflammatory reflex is a vago-vagal reflex that controls immune function. We posit that, in the endotoxaemic animal model, the vagus nerves do not appear to play a role. The evidence suggests that the efferent motor pathway, termed here the 'splanchnic anti-inflammatory pathway', is purely sympathetic, travelling via the greater splanchnic nerves to regulate the ensuing inflammatory response to immune challenges...
October 1, 2016: Experimental Physiology
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