keyword
MENU ▼
Read by QxMD icon Read
search

microbiota transplant

keyword
https://www.readbyqxmd.com/read/28214091/multidonor-intensive-faecal-microbiota-transplantation-for-active-ulcerative-colitis-a-randomised-placebo-controlled-trial
#1
Sudarshan Paramsothy, Michael A Kamm, Nadeem O Kaakoush, Alissa J Walsh, Johan van den Bogaerde, Douglas Samuel, Rupert W L Leong, Susan Connor, Watson Ng, Ramesh Paramsothy, Wei Xuan, Enmoore Lin, Hazel M Mitchell, Thomas J Borody
BACKGROUND: The intestinal microbiota is implicated in the pathogenesis of ulcerative colitis. Faecal microbiota transplantation is a novel form of therapeutic microbial manipulation, but its efficacy in ulcerative colitis is uncertain. We aimed to establish the efficacy of intensive-dosing, multidonor, faecal microbiota transplantation in active ulcerative colitis. METHODS: We conducted a multicentre, double-blind, randomised, placebo-controlled trial at three hospitals in Australia...
February 14, 2017: Lancet
https://www.readbyqxmd.com/read/28199845/host-genotype-and-gut-microbiome-modulate-insulin-secretion-and-diet-induced-metabolic-phenotypes
#2
Julia H Kreznar, Mark P Keller, Lindsay L Traeger, Mary E Rabaglia, Kathryn L Schueler, Donald S Stapleton, Wen Zhao, Eugenio I Vivas, Brian S Yandell, Aimee Teo Broman, Bruno Hagenbuch, Alan D Attie, Federico E Rey
Genetic variation drives phenotypic diversity and influences the predisposition to metabolic disease. Here, we characterize the metabolic phenotypes of eight genetically distinct inbred mouse strains in response to a high-fat/high-sucrose diet. We found significant variation in diabetes-related phenotypes and gut microbiota composition among the different mouse strains in response to the dietary challenge and identified taxa associated with these traits. Follow-up microbiota transplant experiments showed that altering the composition of the gut microbiota modifies strain-specific susceptibility to diet-induced metabolic disease...
February 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28197380/the-influence-of-gut-decontamination-prophylactic-antibiotics-on-acute-graft-versus-host-disease-and-survival-following-allogeneic-hematopoietic-stem-cell-transplantation
#3
Bertrand Routy, Caroline Letendre, David Enot, Maxime Chénard-Poirier, Vikram Mehraj, Noémie Charbonneau Séguin, Khaled Guenda, Kathia Gagnon, Paul-Louis Woerther, David Ghez, Silvy Lachance
The intestinal microbiota plays a key role in the pathogenesis of acute graft-versus-host disease (aGVHD). High-dose conditioning regimens given prior to allogeneic hematopoietic stem cell transplantation (aHSCT) modulate the composition of gut microbiota and damage the gut epithelial barrier, resulting in increased systemic inflammation. We assessed whether gut decontamination with antibiotics (ATB) prior to aHSCT influenced the frequency of aGVHD and mortality in 500 patients from two Canadian centers between 2005 and 2012...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28196423/fecal-microbiota-transplantation-is-there-a-role-in-the-eradication-of-carbapenem-resistant-klebsiella-pneumoniae-intestinal-carriage
#4
Ana Ponte, Rolando Pinho, Margarida Mota
The authors present the case of a 66-year-old woman with four hospitalizations due to recurrent Clostridium difficile infection (CDI) non responsive to vancomycin and fidaxomicin. Furthermore, intestinal colonization with carbapenem-resistant Klebsiella pneumoniae (CRKP) was identified after a positive stool culture in a screening routinely performed in our center in patients recently hospitalized.
February 15, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28195180/successful-resolution-of-recurrent-clostridium-difficile-infection-using-freeze-dried-encapsulated-fecal-microbiota-pragmatic-cohort-study
#5
Christopher Staley, Matthew J Hamilton, Byron P Vaughn, Carolyn T Graiziger, Krista M Newman, Amanda J Kabage, Michael J Sadowsky, Alexander Khoruts
OBJECTIVES: Fecal microbiota transplantation (FMT) is increasingly being used for treatment of recurrent Clostridium difficile infection (R-CDI) that cannot be cured with antibiotics alone. In addition, FMT is being investigated for a variety of indications where restoration or restructuring of the gut microbial community is hypothesized to be beneficial. We sought to develop a stable, freeze-dried encapsulated preparation of standardized fecal microbiota that can be used for FMT with ease and convenience in clinical practice and research...
February 14, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28195066/successful-therapy-of-clostridium-difficile-infection-with-fecal-microbiota-transplantation
#6
P C Konturek, J Koziel, W Dieterich, D Haziri, S Wirtz, I Glowczyk, K Konturek, M F Neurath, Y Zopf
Clostridium difficile infection (CDI) is the most common cause of infectious diarrhea and represents an important burden for healthcare worldwide. Symptoms of severe CDI include watery, foul-smelling diarrhea, peripheral leucocytosis, increased C-reactive protein (CRP), acute renal failure, hypotension and pseudomembranous colitis. Recent studies indicate that the main cause of CDI is dysbiosis, an imbalance in the normal gut microbiota. The restoration of a healthy gut microbiota composition via fecal microbiota transplantation (FMT) recently became more popular...
December 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28192251/antibiotic-induced-depletion-of-anti-inflammatory-clostridia-is-associated-with-the-development-of-gvhd-in-pediatric-stem-cell-transplant-patients
#7
Tiffany R Simms-Waldrip, Gauri Sunkersett, Laura A Coughlin, Milan R Savani, Carlos Arana, Jiwoong Kim, Minsoo Kim, Xiaowei Zhan, David E Greenberg, Yang Xie, Stella M Davies, Andrew Y Koh
Adult stem cell transplantation (SCT) patients with graft-versus-host-disease (GVHD) exhibit significant disruptions in gut microbial communities. These changes are associated with higher overall mortality and appear to be driven by specific antibiotic therapies. It is unclear whether pediatric SCT patients who develop GVHD exhibit similar antibiotic-induced gut microbiota community changes. Here, we show that pediatric SCT patients (from Children's Medical Center Dallas, n=8, and Cincinnati Children's Hospital, n=7) who develop GVHD show a significant decline, up to 10-log fold, in gut anti-inflammatory Clostridia (AIC), compared to those without GVHD...
February 9, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28187526/secondary-bile-acid-induced-dysbiosis-promotes-intestinal-carcinogenesis
#8
Hailong Cao, Mengque Xu, Wenxiao Dong, Baoru Deng, Sinan Wang, Yujie Zhang, Shan Wang, Shenhui Luo, Weiqiang Wang, Yanrong Qi, Jianxin Gao, Xiaocang Cao, Fang Yan, Bangmao Wang
The gut microbiota plays an important role in maintaining intestinal homeostasis. Dysbiosis is associated with intestinal tumorigenesis. Deoxycholic acid (DCA), a secondary bile acid increased by a western diet, is associated with intestinal carcinogenesis. However, evidence relating bile acids, intestinal microbiota and tumorigenesis is limited. In this study, we investigated the effect of DCA on induction of intestinal dysbiosis and its roles in intestinal carcinogenesis. Alteration of the composition of the intestinal microbiota was induced in DCA-treated mice, which was accompanied by impaired intestinal barrier, gut low grade inflammation and tumor progression...
February 10, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28181098/effect-of-aging-on-the-composition-of-fecal-microbiota-in-donors-for-fmt-and-its-impact-on-clinical-outcomes
#9
Rohit Anand, Yang Song, Shashank Garg, Mohit Girotra, Amitasha Sinha, Anita Sivaraman, Laila Phillips, Sudhir K Dutta
BACKGROUND: Fecal microbiota transplantation (FMT) is emerging as an effective therapy for the treatment of recurrent Clostridium difficile infection (RCDI). Selecting an appropriate donor is vital to the success of FMT. However, the relationship between age of donors and the efficacy of FMT has not been examined to date. The aim of this study was to examine the effect of age of healthy donors on their fecal microbiota and assess the impact of these changes on the clinical efficacy of FMT...
February 8, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28179014/mirkat-s-a-community-level-test-of-association-between-the-microbiota-and-survival-times
#10
Anna Plantinga, Xiang Zhan, Ni Zhao, Jun Chen, Robert R Jenq, Michael C Wu
BACKGROUND: Community-level analysis of the human microbiota has culminated in the discovery of relationships between overall shifts in the microbiota and a wide range of diseases and conditions. However, existing work has primarily focused on analysis of relatively simple dichotomous or quantitative outcomes, for example, disease status or biomarker levels. Recently, there is also considerable interest in the relationship between the microbiota and censored survival outcomes, such as in clinical trials...
February 8, 2017: Microbiome
https://www.readbyqxmd.com/read/28178876/designing-fecal-microbiota-transplant-trials-that-account-for-differences-in-donor-stool-efficacy
#11
Scott W Olesen, Thomas Gurry, Eric J Alm
Fecal microbiota transplantation is a highly effective intervention for patients suffering from recurrent Clostridium difficile, a common hospital-acquired infection. Fecal microbiota transplantation's success as a therapy for C. difficile has inspired interest in performing clinical trials that experiment with fecal microbiota transplantation as a therapy for other conditions like inflammatory bowel disease, obesity, diabetes, and Parkinson's disease. Results from clinical trials that use fecal microbiota transplantation to treat inflammatory bowel disease suggest that, for at least one condition beyond C...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28178052/fecal-microbiota-transplant-for-clostridium-difficile-infection-in-a-pregnant-patient
#12
Bejan J Saeedi, Doree Gardner Morison, Colleen S Kraft, Tanvi Dhere
BACKGROUND: Clostridium difficile infection has been associated with negative outcomes in the general population and in pregnant patients. Fecal microbiota transplant has become the standard for treatment of recurrent as well as refractory C difficile infection. CASE: We present a case of a 28-year-old pregnant woman who presented with recurrent C difficile infection despite treatment with vancomycin and fidaxomicin and underwent a successful fecal microbiota transplant through colonoscopy at 18 weeks of gestation...
February 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28175260/p782-a-new-compatibility-test-for-donor-selection-for-faecal-microbiota-transplantation-in-ulcerative-colitis
#13
M Ponce-Alonso, S Garcia-Fernandez, L Aguilera, E Rodriguez-de-Santiago, J R Foruny, G Roy, R DelCampo, R Canton, A Lopez-Sanroman
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174938/op036-short-duration-low-intensity-pooled-faecal-microbiota-transplantation-induces-remission-in-patients-with-mild-moderately-active-ulcerative-colitis-a-randomised-controlled-trial
#14
S Costello, O Waters, R Bryant, R Katsikeros, J Makanyanga, M Schoeman, R Mountifield, D Tee, S Howell, P Hughes, M Conlon, I Roberts-Thomson, J Andrews
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172822/p589-faecal-microbiota-transplantation-for-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis
#15
S Paramsothy, R Paramsothy, M Kamm, N Kaakoush, H Mitchell, D Rubin, N Castaño-Rodríguez
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172648/p743-what-information-is-available-on-the-internet-and-social-media-for-faecal-microbiota-transplantation
#16
J Segal, F Abbasi, C Kanagasundram, A Hart
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172473/dop080-low-viral-richness-at-baseline-in-ulcerative-ulcerative-colitis-associated-with-faecal-microbiota-transplantation-success
#17
N Conceição-Neto, W Deboutte, T Dierckx, K Machiels, J Wang, C Yinda, P Maes, M Van Ranst, M Joossens, J Raes, S Vermeire, J Matthijnssens
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28164849/fecal-microbiota-transplantation
#18
REVIEW
Stephen M Vindigni, Christina M Surawicz
Fecal microbiota transplantation (FMT) is the transfer of stool from a healthy donor into the colon of a patient whose disease is a result of an altered microbiome, with the goal of restoring the normal microbiota and thus curing the disease. The most effective and well-studied indication for FMT is recurrent Clostridium difficile infection. At this time, there is insufficient evidence to recommend FMT for other gastrointestinal diseases, but studies are under way. There is also insufficient evidence to recommend FMT for nongastrointestinal diseases at this time...
March 2017: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/28158664/fecal-microbiota-transplant-versus-oral-vancomycin-taper-important-undiscussed-limitations
#19
Jeffrey W Jansen
No abstract text is available yet for this article.
February 3, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28158478/fecal-microbiota-transplantation-do-we-need-harmonization
#20
Tatiana Galpérine, Harry Sokol, Benoît Guery
No abstract text is available yet for this article.
February 3, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
keyword
keyword
101799
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"