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Old age depression

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https://www.readbyqxmd.com/read/27931772/the-impact-of-depressive-symptoms-on-healthcare-costs-in-late-life-longitudinal-findings-from-the-agemoode-study
#1
Jens-Oliver Bock, André Hajek, Siegfried Weyerer, Jochen Werle, Michael Wagner, Wolfgang Maier, Anne Stark, Hanna Kaduszkiewicz, Birgitt Wiese, Lilia Moor, Janine Stein, Steffi G Riedel-Heller, Hans-Helmut König
OBJECTIVE: To examine whether depressive symptoms affect healthcare costs in old age longitudinally. DESIGN: Multicenter prospective observational cohort study (two waves with nt1 = 1,195 and nt2 = 951) in Germany. SETTING: Community. PARTICIPANTS: Participants aged 75 years and older recruited via general practitioners. MEASUREMENTS: Depressive symptoms were assessed by the Geriatric Depression Scale (GDS)...
November 2, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27928477/health-related-quality-of-life-and-health-utility-values-in-beta-thalassemia-major-patients-receiving-different-types-of-iron-chelators-in-iran
#2
Meysam Seyedifar, Farid Abedin Dorkoosh, Amir Ali Hamidieh, Majid Naderi, Hossein Karami, Mehran Karimi, Masoomeh Fadaiyrayeny, Masoumeh Musavi, Sanaz Safaei, Mohammad Mahdi Ahmadian-Attari, Molouk Hadjibabaie, Abdol Majid Cheraghali, Ali Akbari Sari
Background: Thalassemia is a chronic, inherited blood disorder, which in its most severe form, causes life-threatening anemia. Thalassemia patients not only engage with difficulties of blood transfusion and iron chelating therapy but also have some social challenges and health threatening factors. There are some reports on quality of life in thalassemia patients around the world from southeast of Asia to Italy in Europe and United States. In this study, we tried to evaluate and compare Health Related Quality of life (HRQoL) and the health utility in beta thalassemia major patients receiving different types of iron chelators and living in different socio-economical situations...
October 1, 2016: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/27928152/a-10-year-interval-study-to-compare-the-prevalence-and-risk-factors-of-female-sexual-dysfunction-in-korea-the-korean-internet-sexuality-survey-kiss-2014
#3
H Shin, B Min, J Park, H Son
Female sexual dysfunction (FSD) is defined as disturbances in sexual desire and the psychophysiological changes that characterize the sexual response cycle, which cause marked distress and interpersonal difficulty. Female sexual dysfunction is strongly related to socio-cultural characteristics of a certain region and can change over time. Authors previously reported the features of FSD in Korea through an analysis of an internet-based survey conducted in 2004. This time, we designed a 10-year interval study to compare the prevalence of and risk factors of FSD through the Korean Internet Sexuality Survey (KISS) 2014...
December 8, 2016: International Journal of Impotence Research
https://www.readbyqxmd.com/read/27923390/the-rapid-ctca-trial-rapid-assessment-of-potential-ischaemic-heart-disease-with-ctca-a-multicentre-parallel-group-randomised-trial-to-compare-early-computerised-tomography-coronary-angiography-versus-standard-care-in-patients-presenting-with-suspected-or-confirmed
#4
Alasdair J Gray, Carl Roobottom, Jason E Smith, Steve Goodacre, Katherine Oatey, Rachel O'Brien, Robert F Storey, Lumine Na, Steff C Lewis, Praveen Thokala, David E Newby
BACKGROUND: Emergency department attendances with chest pain requiring assessment for acute coronary syndrome (ACS) are a major global health issue. Standard assessment includes history, examination, electrocardiogram (ECG) and serial troponin testing. Computerised tomography coronary angiography (CTCA) enables additional anatomical assessment of patients for coronary artery disease (CAD) but has only been studied in very low-risk patients. This trial aims to investigate the effect of early CTCA upon interventions, event rates and health care costs in patients with suspected/confirmed ACS who are at intermediate risk...
December 7, 2016: Trials
https://www.readbyqxmd.com/read/27922637/a-human-carboxypeptidase-e-nf-%C3%AE-1-gene-mutation-in-an-alzheimer-s-disease-patient-leads-to-dementia-and-depression-in-mice
#5
Y Cheng, N X Cawley, T Yanik, S R K Murthy, C Liu, F Kasikci, D Abebe, Y P Loh
Patients with Alzheimer's disease (AD), a common dementia among the aging population, often also suffer from depression. This comorbidity is poorly understood. Although most forms of AD are not genetically inherited, we have identified a new human mutation in the carboxypeptidase E (CPE)/neurotrophic factor-α1 (NF-α1) gene from an AD patient that caused memory deficit and depressive-like behavior in transgenic mice. This mutation consists of three adenosine inserts, introducing nine amino acids, including two glutamines into the mutant protein, herein called CPE-QQ...
December 6, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27919247/the-cross-interaction-between-global-and-age-comparative-self-rated-health-on-depressive-symptoms-considering-both-the-individual-and-combined-effects
#6
Jaeyong Shin, Eun-Cheol Park, Sang Gyu Lee, Young Choi, Jae-Hyun Kim, Tae Hyun Kim
BACKGROUND: Numerous studies suggesting the relation between self-rated health (SRH) and depression have been reported using different measures. Therefore, we attempted to determine the difference in a depressive scale based on the different ways of measuring health between global SRH (SRH-global) and age-comparative SRH (SRH-age). Then, the combined effect of SRH-global and SRH-age on depressive symptoms was further investigated. METHODS: Data from the Korean Longitudinal Study of Ageing (KLoSA) from 2008 to 2012 were analyzed...
December 5, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27917116/preliminary-evidence-of-apathetic-like-behavior-in-aged-vesicular-monoamine-transporter-2-deficient-mice
#7
Aron Baumann, Carlos G Moreira, Marta M Morawska, Sophie Masneuf, Christian R Baumann, Daniela Noain
Apathy is considered to be a core feature of Parkinson's disease (PD) and has been associated with a variety of states and symptoms of the disease, such as increased severity of motor symptoms, impaired cognition, executive dysfunction and dementia. Apart from the high prevalence of apathy in PD, which is estimated to be about 40%, the underlying pathophysiology remains poorly understood and current treatment approaches are unspecific and proved to be only partially effective. In animal models, apathy has been sub-optimally modeled, mostly by means of pharmacological and stress-induced methods, whereby concomitant depressive-like symptoms could not be ruled out...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27913760/neighborhood-physical-disorder-and-psychological-distress-does-the-risk-increase-with-age
#8
Manacy Pai, Joongbaeck Kim
Although research documents a link between neighborhood physical disorder and psychological distress, we know little about the extent to which this association varies by age. Utilizing the person-environment fit model and drawing on data from the fourth wave of the Americans' Changing Lives Survey, we examine the extent to which age influences the association between perceptions of neighborhood physical disorder and psychological distress, as measured by depressive symptoms. We employ both continuous and categorical measures of age to test for a potential moderating effect...
December 2, 2016: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/27901275/peripheral-nerve-blocks-for-the-treatment-of-headache-in-older-adults-a-retrospective-study
#9
Jacob R Hascalovici, Matthew S Robbins
OBJECTIVE: The objective of this study is to provide demographical and clinical descriptions of patients age 65 years old and older who were treated with peripheral nerve blocks (PNBs) at our institution and evaluate the safety and efficacy of this treatment. BACKGROUND: Headache disorders are common, disabling chronic neurological diseases that often persist with advancing age. Geriatric headache management poses unique therapeutic challenges because of considerations of comorbidity, drug interactions, and adverse effects...
November 30, 2016: Headache
https://www.readbyqxmd.com/read/27899687/reliability-and-validity-of-the-pittsburgh-sleep-quality-index-serbian-translation
#10
Martin B Popević, Aleksandar P S Milovanović, Srdjan Milovanović, Ljudmila Nagorni-Obradović, Dejan Nešić, Marija Velaga
The aim of this study was translating and exploring psychometric properties of Serbian Pittsburgh Sleep Quality Index (PSQI) in a sample of "good" and "bad" sleepers suffering from depression or obstructive sleep apnea (OSA). Formal translation and validation were performed on a sample of healthy controls, patients with untreated OSA, and with diagnosed major depressive disorder with evaluation of internal consistency, test-retest reliability, and construct and criterion validity. Controls and OSA subgroups were recruited from a larger sample of commercial drivers...
November 28, 2016: Evaluation & the Health Professions
https://www.readbyqxmd.com/read/27899129/a-community-based-study-on-prevalence-and-correlates-of-erectile-dysfunction-among-kinondoni-district-residents-dar-es-salaam-tanzania
#11
Pedro Pallangyo, Paulina Nicholaus, Peter Kisenge, Henry Mayala, Noel Swai, Mohamed Janabi
BACKGROUND: Globally, erectile dysfunction burden (ED) is rising appreciably and it is projected to affect about 332 million men by the year 2025. This rise is attributable to the rising incidence of conditions associated with ED including obesity, diabetes, hypertension, coronary artery disease and depression. We conducted this community-based screening to elucidate on the prevalence of ED and its associated factors among men residing in an urban community in Tanzania. METHODS: We conducted a cross-sectional community-based study and interviewed 441 men aged at least 18 years...
November 29, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27898840/one-hour-portable-chamber-methane-measurements-are-repeatable-and-provide-useful-information-on-feed-intake-and-efficiency
#12
D L Robinson, M Cameron, A J Donaldson, S Dominik, V H Oddy
Feed intake (FI), live weight (LW), and ADG were recorded over 31 d in ninety-six 12-month-old ewes (progeny of 4 sires) given ad libitum access to chaffed lucerne/cereal hay. Methane (CH) and CO emissions of each ewe were measured for 40 to 60 min in portable accumulation chambers (PAC) and in respiration chambers (RC) over 22 h. Testing in RC increased the variability of FI on the test day and depressed the amount eaten from an average of 1,384 to 1,062 g/d; FI depression increased by 0.63 ± 0.24 percentage points for every kilogram of additional LW...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27896936/health-related-quality-of-life-and-adherence-to-hydroxyurea-in-adolescents-and-young-adults-with-sickle-cell-disease
#13
Sherif M Badawy, Alexis A Thompson, Jin-Shei Lai, Frank J Penedo, Karen Rychlik, Robert I Liem
BACKGROUND: Complications related to sickle cell disease (SCD) result in significant declines in health-related quality of life (HRQOL). While hydroxyurea reduces SCD complications, adherence remains suboptimal. The study's objectives were to assess the feasibility of Internet-based electronic assessment of HRQOL in SCD clinic and to examine the relationship between HRQOL and hydroxyurea adherence in adolescents and young adults (AYAs) with SCD. PROCEDURE: A cross-sectional survey was administered on tablets to 34 AYAs (12-22 years old) in a SCD clinic from January through December 2015...
November 28, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27896676/what-is-the-incidence-of-suicide-in-patients-with-bone-and-soft-tissue-cancer-suicide-and-sarcoma
#14
Brianna L Siracuse, George Gorgy, Jeremy Ruskin, Kathleen S Beebe
BACKGROUND: Patients with cancer in the United States are estimated to have a suicide incidence that is approximately twice that of the general population. Patients with bone and soft tissue cancer often have physical impairments and activity limitations develop that reduce their quality of life, which may put them at high risk for depression, anxiety, and suicidal ideation. To our knowledge, there have been no large studies determining incidence of suicide among patients with bone and soft tissue cancer; this information might allow screening of certain high-risk groups...
November 28, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27895577/fus1-ko-mouse-as-a-model-of-oxidative-stress-mediated-sporadic-alzheimer-s-disease-circadian-disruption-and-long-term-spatial-and-olfactory-memory-impairments
#15
Guillermo Coronas-Samano, Keeley L Baker, Winston J T Tan, Alla V Ivanova, Justus V Verhagen
Insufficient advances in the development of effective therapeutic treatments of sporadic Alzheimer's Disease (sAD) to date are largely due to the lack of sAD-relevant animal models. While the vast majority of models do recapitulate AD's hallmarks of plaques and tangles by virtue of tau and/or beta amyloid overexpression, these models do not reflect the fact that in sAD (unlike familial AD) these genes are not risk factors per se and that other mechanisms like oxidative stress, metabolic dysregulation and inflammation play key roles in AD etiology...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27894296/relationship-between-body-mass-index-and-depressive-symptoms-the-fat-and-jolly-hypothesis-for-the-middle-aged-and-elderly-in-china
#16
Lin Zhang, Kun Liu, Hong Li, Dan Li, Zhuo Chen, Li-Li Zhang, Lei-Lei Guo
BACKGROUND: Obesity has been identified as a worldwide epidemic. In China, the highest prevalence of obesity is observed in adults aged ≥45 years old. This study aimed to describe the association between BMI and depressive symptoms among a large representative sample of middle-aged and elderly in China. METHOD: A longitudinal sample of the middle-aged and elderly (6,224 males and 6,883 females) who were interviewed in the 2011 China Health and Retirement Longitudinal Study was used...
November 29, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27893238/does-anger-regulation-mediate-the-discrimination-mental-health-link-among-mexican-origin-adolescents-a-longitudinal-mediation-analysis-using-multilevel-modeling
#17
Irene J K Park, Lijuan Wang, David R Williams, Margarita Alegría
Although prior research has consistently documented the association between racial/ethnic discrimination and poor mental health outcomes, the mechanisms that underlie this link are still unclear. The present 3-wave longitudinal study tested the mediating role of anger regulation in the discrimination-mental health link among 269 Mexican-origin adolescents (Mage = 14.1 years, SD = 1.6; 57% girls), 12 to 17 years old. Three competing anger regulation variables were tested as potential mediators: outward anger expression, anger suppression, and anger control...
November 28, 2016: Developmental Psychology
https://www.readbyqxmd.com/read/27889589/higher-morale-is-associated-with-lower-risk-of-depressive-disorders-five-years-later-among-very-old-people
#18
Johan Niklasson, Marina Näsman, Fredrica Nyqvist, Mia Conradsson, Birgitta Olofsson, Hugo Lövheim, Yngve Gustafson
The aim of this study was to investigate whether higher morale, i.e. future-oriented optimism, at baseline was associated with lower risk of depressive disorders five years later among very old people.Methods The Umeå85+/GErontological Regional Database, a population-based study with a longitudinal design, recruited participants in Sweden and Finland aged 85, 90 and ≥95 years. The sample in the present study included 647 individuals (89.1±4.4 years (Mean±SD), range 85-103). After five years, 216 were alive and agreed to a follow-up (92...
November 17, 2016: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27887583/impact-of-physical-and-mental-health-on-life-satisfaction-in-old-age-a-population-based-observational-study
#19
Thomas Puvill, Jolanda Lindenberg, Antonius J M de Craen, Joris P J Slaets, Rudi G J Westendorp
BACKGROUND: It is widely assumed that poor health lowers life satisfaction when ageing. Yet, research suggests this relationship is not straightforward. This study investigated how older people evaluate their life when facing disease and disabilities. METHODS: The Leiden 85-plus Study, a prospectively followed cohort of a cohort of a middle-sized city in the Netherlands, all aged 85 years, that was age-representative of the general population, was used. Those with severe cognitive dysfunction were excluded (n = 501)...
November 25, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27881145/evaluation-of-efficacy-and-efficiency-of-a-pragmatic-intervention-by-a-social-worker-to-support-informal-caregivers-of-elderly-patients-the-ice-study-study-protocol-for-a-randomized-controlled-trial
#20
Astrid Pozet, Catherine Lejeune, Magalie Bonnet, Sandrine Dabakuyo, Michèle Dion, Philippe Fagnoni, Maryse Gaimard, Geneviève Imbert, Virginie Nerich, Audrey Foubert, Morgane Chotard, Marie Bonin, Amélie Anota, Franck Bonnetain
BACKGROUND: Medical progress and the lifestyle modification have prolonged life expectancy, despite the development of chronic diseases. Support and care for older subjects are often provided by a network of informal caregivers composed of family, friends and neighbors, who are essential in helping older persons to continue living at home. It has been shown that the extent and diversity of informal tasks may jeopardize the physical, mental and social wellbeing of caregivers. METHODS/DESIGN: The aim of the Informal Carers of Elderly cohort is to define, through a longitudinal study, profiles of caregivers of older patients with a diagnosis of one of the following diseases: cancer (breast, prostate, colorectal), neurodegenerative diseases (Parkinson's disease, Alzheimer's disease and similar diseases), neurovascular diseases (stroke), sensory diseases (age-related macular degeneration (AMD)) and heart disease (heart failure)...
November 3, 2016: Trials
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