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https://www.readbyqxmd.com/read/29140820/renal-effects-of-cytokines-in-hypertension
#1
Yi Wen, Steven D Crowley
PURPOSE OF REVIEW: Inflammatory cytokines contribute to the pathogenesis of hypertension through effects on renal blood flow and sodium handling. This review will update recent advances that explore the renal actions of immune cells and cytokines in the pathogenesis of hypertension. RECENT FINDINGS: Populations of cells from both the innate and adaptive immune systems contribute to hypertension by modulating functions of the vasculature and epithelial cells in the kidney...
November 14, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29140635/emergency-department-visits-for-hand-and-finger-injuries-associated-with-the-use-of-log-splitters
#2
Bart Hammig, Ches Jones
The purpose of this study was to examine patients treated in an emergency department (ED) for injuries related to the use of log splitters. Data were obtained from the National Electronic Injury Surveillance System for the years 2011-2014. National estimates of ED visits for injuries associated with the use of log splitters were obtained, and descriptive epidemiological characteristics are presented. An estimated 37,000 ED visits for injuries related to the use of log splitters occurred during the study period...
April 26, 2017: Journal of Agricultural Safety and Health
https://www.readbyqxmd.com/read/29140128/lower-extremity-musculoskeletal-injury-risk-after-concussion-recovery-in-high-school-athletes
#3
Robert C Lynall, Timothy C Mauntel, Ryan T Pohlig, Zachary Y Kerr, Thomas P Dompier, Eric E Hall, Thomas A Buckley
CONTEXT:   Although an association between concussion and musculoskeletal injury has been described in collegiate and professional athletes, no researchers have investigated an association in younger athletes. OBJECTIVE:   To determine if concussion in high school athletes increased the risk for lower extremity musculoskeletal injury after return to activity. DESIGN:   Observational cohort study. SETTING:   One hundred ninety-six high schools across 26 states...
November 15, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/29138589/clinical-characteristics-and-outcome-of-toxicity-from-amanita-mushroom-poisoning
#4
Satariya Trakulsrichai, Charuwan Sriapha, Achara Tongpoo, Umaporn Udomsubpayakul, Sunun Wongvisavakorn, Sahaphume Srisuma, Winai Wananukul
Objective: To describe and analyze the clinical characteristics and outcome of amatoxin poisoning cases. Methods: We performed a retrospective cohort study of amatoxin poisoning cases from Ramathibodi Poison Center Toxic Exposure Surveillance System, from May 2013 to August 2015. Results: There were 30 consultations with a total of 55 poisoning cases. Most cases were male and from the north-east region. Hepatitis, acute kidney injury, jaundice, and coagulopathy accounted for 74%, 46...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/29136724/-expert-consensus-for-the-diagnosis-and-treatment-of-patients-with-renal-impairment-of-multiple-myeloma
#5
(no author information available yet)
Renal impairment (RI) is a common complication of multiple myeloma (MM), which is presented as chronic kidney disease (CKD) or acute kidney injury (AKI). The typical pathological feature is cast nephropathy. Presently international system staging (ISS) is used in evaluating MM. Although the classic Durie-Salmon staging system could be still used in clinical practice, it may miss out some patients with renal impairment. For evaluations of RI in MM patients with CKD, it's recommended to assess the estimated glomerular filtration rate (eGFR) by creatinine based formula CKD-epidemiology collaboration (EPI) or modification of diet in renal disease(MDRD) and to stage the renal injuries according to 2013 Kidney Disease Improving Global Outcomes (KDIGO) CKD guidelines...
November 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29135818/trends-of-magnet-ingestion-in-children-an-ironic-attraction
#6
Patrick Todd Reeves, Cade M Nylund, Jayasree Krishnamurthy, R Adam Noel, Mazen I Abbas
BACKGROUND AND OBJECTIVES: Ingestion of rare earth magnets is a serious ongoing hazard for pediatric patients. Our study aims to investigate whether 2012 Consumer Product Safety Commission (CPSC) policy action, in coordination with efforts from consumer and physician advocacy groups, decreased the incidence of magnet ingestions in children in US since 2012. METHODS: Data from the National Electronic Injury Surveillance System (NEISS) was used to evaluate trends in emergency department (ED) encounters with pediatric patients (<18 years) who presented with suspected magnet ingestions (SMI) from 2010-2015...
November 11, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29133295/head-injury-mechanisms-in-fis-world-cup-alpine-and-freestyle-skiers-and-snowboarders
#7
Sophie Elspeth Steenstrup, Arnhild Bakken, Tone Bere, Declan Alexander Patton, Roald Bahr
INTRODUCTION: Head injuries represent a concern in skiing and snowboarding, with traumatic brain injuries being the most common cause of death. AIM: To describe the mechanisms of head and face injuries among World Cup alpine and freestyle skiers and snowboarders. METHODS: We performed a qualitative analysis of videos obtained of head and face injuries reported through the International Ski Federation Injury Surveillance System during 10 World Cup seasons (2006-2016)...
November 13, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29127808/improving-autocoding-performance-of-rare-categories-in-injury-classification-is-more-training-data-or-filtering-the-solution
#8
Gaurav Nanda, Kirsten Vallmuur, Mark Lehto
INTRODUCTION: Classical Machine Learning (ML) models have been found to assign the external-cause-of-injury codes (E-codes) based on injury narratives with good overall accuracy but often struggle with rare categories, primarily due to lack of enough training cases and heavily skewed nature of injurdata. In this paper, we have: a) studied the effect of increasing the size of training data on the prediction performance of three classical ML models: Multinomial Naïve Bayes (MNB), Support Vector Machine (SVM) and Logistic Regression (LR), and b) studied the effect of filtering based on prediction strength of LR model when the model is trained on very-small (10,000 cases) and very-large (450,000 cases) training sets...
November 8, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29125989/prediction-of-mortality-risk-in-victims-of-violent-crimes
#9
Rolf Gedeborg, Bodil Svennblad, Liisa Byberg, Karl Michaëlsson, Ingemar Thiblin
BACKGROUND: To predict mortality risk in victims of violent crimes based on individual injury diagnoses and other information available in health care registries. METHODS: Data from the Swedish hospital discharge registry and the cause of death registry were combined to identify 15,000 hospitalisations or prehospital deaths related to violent crimes. The ability of patient characteristics, injury type and severity, and cause of injury to predict death was modelled using conventional, Lasso, or Bayesian logistic regression in a development dataset and evaluated in a validation dataset...
October 20, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29124057/radiation-induced-cardiovascular-disease-a-clinical-perspective
#10
REVIEW
Syed Wamique Yusuf, Bhanu Prasad Venkatesulu, Lakshmi Shree Mahadevan, Sunil Krishnan
Cancer survival has improved dramatically, and this has led to the manifestation of late side effects of multimodality therapy. Radiation (RT) to the thoracic malignancies results in unintentional irradiation of the cardiac chambers. RT-induced microvascular ischemia leads to disruption of capillary endothelial framework, and injury to differentiated myocytes results in deposition of collagen and fibrosis. Coexistence of risk factors of metabolic syndrome and preexisting atherosclerosis in addition to RT exposure results in accelerated occurrence of major coronary events...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29121926/quantitative-and-qualitative-aspects-of-standing-up-behavior-and-the-prevalence-of-osteochondrosis-in-warmblood-foals-on-different-farms-could-there-be-a-link
#11
E M van Grevenhof, A R D Gezelle Meerburg, M C van Dierendonck, A J M van den Belt, B van Schaik, P Meeus, W Back
BACKGROUND: Osteochondrosis (OC) is a common, clinically important joint disorder in which endochondral ossification is focally disturbed. Reduced blood supply to growing cartilage is considered an important cause of the condition, which has both genetic and environmental origins. Housing conditions can influence cartilage injury through peak-pressure changes during limb sliding. Additionally, circulatory perturbation can cause the avascular necrosis of cartilage. In this study, we evaluated the type and frequency of limb sliding during standing up and the occurrence of OC in foals aged up to 12 months on different farms...
November 9, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29114714/child-injury-surveillance-capabilities-in-nsw-informing-policy-and-practice
#12
Rebecca Mitchell, Luke Testa
Injury is one of the most common reasons why a child is hospitalised. Information gained from injury surveillance activities provides an estimate of the injury burden, describes injury event circumstances, can be used to monitor injury trends over time, and is used to design and evaluate injury prevention activities. This perspective article provides an overview of child injury surveillance capabilities within New South Wales (NSW), Australia, following a stocktake of population-based injury-related data collections using the Evaluation Framework for Injury Surveillance Systems...
October 11, 2017: Public Health Research & Practice
https://www.readbyqxmd.com/read/29102350/prevalence-of-cerebral-palsy-in-uganda-a-population-based-study
#13
Angelina Kakooza-Mwesige, Carin Andrews, Stefan Peterson, Fred Wabwire Mangen, Ann Christin Eliasson, Hans Forssberg
BACKGROUND: Few population-based studies of cerebral palsy have been done in low-income and middle-income countries. We aimed to examine cerebral palsy prevalence and subtypes, functional impairments, and presumed time of injury in children in Uganda. METHODS: In this population-based study, we used a nested, three-stage, cross-sectional method (Iganga-Mayuge Health and Demographic Surveillance System [HDSS]) to screen for cerebral palsy in children aged 2-17 years in a rural eastern Uganda district...
October 25, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29101814/injuries-associated-with-bunk-beds-that-occur-in-jail
#14
Randall T Loder, Jocelyn Cole Young
BACKGROUND: There are many studies of bunk bed injuries, but none specifically addressing those occurring in jails. It was the purpose of this study to investigate the magnitude and patterns of bunk bed injuries occurring in correctional institutions. METHODS: The National Electronic Injury Surveillance System (NEISS) data for the 10 year period 2006 through 2015 due to bunk beds was accessed. Injuries involving bunk beds were identified and the mechanism of injury determined...
October 20, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29099536/aneurysms-in-vascular-access-state-of-the-art-and-future-developments
#15
Nicholas Inston, Hiren Mistry, James Gilbert, David Kingsmore, Zahid Raza, Matteo Tozzi, Ali Azizzadeh, Robert Jones, Colin Deane, Jason Wilkins, Ingemar Davidson, John Ross, Paul Gibbs, Dean Huang, Domenico Valenti
A master class was held at the Vascular Access at Charing Cross (VA@CX2017) conference in April 2017 with invited experts and active audience participation to discuss arteriovenous (AV) vascular access aneurysms, a serious and common complication of vascular access (VA). The natural history of aneurysms in VA is poorly defined, and although classifications exist they are not uniformly applied in studies or clinical practice. True and pseudo aneurysms of AV access occur. Whilst an AV fistula by definition is an abnormal dilatation of a blood vessel, an agreed definition of 18 mm, or 3 times accepted maturation diameter, is proposed...
November 2, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/29093371/-identification-of-biomarkers-for-tubular-injury-and-interstitial-fibrosis-in-chronic-kidney-disease
#16
Shunsaku Nakagawa
 In chronic kidney disease (CKD), progressive nephron loss causes tubulointerstitial fibrosis and progressive tubular injury. Recent identification of the major cell populations of myofibroblast precursors in the kidney has enabled us to dissect the fibrogenic process after tubular injury. Kidney pericytes are a possible precursor of myofibroblasts, and may be promising targets for treating fibrogenesis. Our recent studies have shown that pericytes activate Toll-like receptor (TLR) 2/4- and myeloid differentiation primary response 88 (MyD88)-dependent proinflammatory signaling in response to renal tubular injury...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29092652/head-impact-locations-in-us-high-school-boys-and-girls-soccer-concussions-2012-13-2015-16
#17
Zachary Kerr, Kody R Campbell, Melissa A Fraser, Dustin W Currie, Lauren A Pierpoint, Thomas Kamimski, Jason Mihalik
This study describes concussions and concussion-related outcomes sustained by high school soccer players by head impact location, sex, and injury mechanism. Data were obtained for the 2012/13-2015/16 school years from the National High School Sports-Related Injury Surveillance System, High School RIO™. This Internet-based sports injury surveillance system captures data reported by athletic trainers from an annual average of 162 US high schools. Data were analyzed to describe circumstances of soccer concussion (e...
November 1, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29089621/the-non-invasive-exfoliated-transcriptome-exfoliome-reflects-the-tissue-level-transcriptome-in-a-mouse-model-of-nsaid-enteropathy
#18
Canaan M Whitfield-Cargile, Noah D Cohen, Kejun He, Ivan Ivanov, Jennifer S Goldsby, Ana Chamoun-Emanuelli, Brad R Weeks, Laurie A Davidson, Robert S Chapkin
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most frequently used classes of medications in the world, yet they induce an enteropathy that is associated with high morbidity and mortality. A major limitation to better understanding the pathophysiology and diagnosis of this enteropathy is the difficulty of obtaining information about the primary site of injury, namely the distal small intestine. We investigated the utility of using mRNA from exfoliated cells in stool as a means to surveil the distal small intestine in a murine model of NSAID enteropathy...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29088959/traumatic-brain-injury-and-intracranial-hemorrhage-induced-cerebral-vasospasm-a-systematic-review
#19
Fawaz Al-Mufti, Krishna Amuluru, Abhinav Changa, Megan Lander, Neil Patel, Ethan Wajswol, Sarmad Al-Marsoummi, Basim Alzubaidi, I Paul Singh, Rolla Nuoman, Chirag Gandhi
OBJECTIVE Little is known regarding the natural history of posttraumatic vasospasm. The authors review the pathophysiology of posttraumatic vasospasm (PTV), its associated risk factors, the efficacy of the technologies used to detect PTV, and the management/treatment options available today. METHODS The authors performed a systematic review in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines using the following databases: PubMed, Google Scholar, and CENTRAL (the Cochrane Central Register of Controlled Trials)...
November 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29084102/lifetime-history-of-traumatic-brain-injury-and-current-disability-among-ohio-adults
#20
Honggang Yi, John D Corrigan, Bhavna Singichetti, Jennifer A Bogner, Kara Manchester, Jinhong Guo, Jingzhen Yang
OBJECTIVE: To examine the associations between lifetime history of traumatic brain injury (TBI) with loss of consciousness (LOC) and several types of current disability among adult, noninstitutionalized residents of Ohio. PARTICIPANTS: 2014 Ohio Behavioral Risk Factors Surveillance System participants (n = 6998). DESIGN: Statewide population-based survey. MAIN MEASURES: Lifetime history of TBI with LOC (number and severity of injury, age of first injury), and number and type of disability (vision, cognition, mobility, self-care, and/or independent living)...
October 27, 2017: Journal of Head Trauma Rehabilitation
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