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Lower limb injuries

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https://www.readbyqxmd.com/read/28641058/acute-kinematics-changes-in-marathon-runners-using-different-footwear
#1
Tania Socorro Amorim Soares, Camila Fonseca de Oliveira, Federico Pizzuto, Rui Manuel Garganta, João Paulo Vila-Boas, Mario Casimiro da Anunciação Paiva
The effects of running with or without shoes on injury prevention have been extensively studied, and several investigations have assessed biomechanical differences between them. However, findings are not consensual and further insights on biomechanical load associated with differently shod or barefoot conditions may be needed. This study aimed to observe if habitually shod marathon runners show acute alterations when running barefoot or with minimalist shoes, and to determine whether the running kinematical adaptations of wearing minimalist shoes were similar to barefoot running...
June 22, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28636440/effects-of-time-to-start-training-after-acute-patellar-tendon-enthesis-injuries-on-healing-of-the-injury-in-a-rabbit-model
#2
Lin Wang, Kaiyu Xiong, Bo Wang, Xiaotian Liang, Haiwei Li, Haitao Liu, Hui He
BACKGROUND: A patellar tendon injury is a common injury in sports. The optimal time to start training after an acute, proximal patellar enthesis injury is still unclear. HYPOTHESIS: The time to start training after an acute, proximal patellar enthesis injury significantly affects healing of the patellar tendon 4 weeks after the injury. STUDY DESIGN: Controlled laboratory study. METHODS: The left hindlimbs of 35 mature female rabbits were randomly assigned to 5 injury groups including a 4-week natural healing group (NH4W) and 4 training groups that started low-intensity training at 24 hours (POST24), 48 hours (POST48), 72 hours (POST72), and 96 hours (POST96) after an acute patellar tendon injury, with 7 limbs in each group...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28633926/synergic-stimulation-of-serotonin-5-ht1a-receptor-and-%C3%AE-2-adrenoceptors-for-neuropathic-pain-relief-preclinical-effects-of-2-substituted-imidazoline-derivatives
#3
Lorenzo Di Cesare Mannelli, Carla Ghelardini, Laura Micheli, Fabio Del Bello, Mario Giannella, Alessandro Piergentili, Wilma Quaglia
Neuropathic pain affects millions of people causing disability and impairing quality of life. Commonly used analgesics are generally characterized by limited therapeutic outcomes. The serotonin 5-HT1A receptor and the α2 adrenergic receptors are involved in central nociceptive mechanisms with a pivotal role in the inhibitory descending pain pathway. Since their stimulation may modulate the nervous signaling altered by neuropathies, the purpose of the present research is the study of the combined activation of 5-HT1A and α2 receptors by rationally designed imidazoline ligands ((S)-1 and 2-5) in a rat model of neuropathic pain (chronic constriction injury - CCI)...
June 17, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28633788/fluoroscopic-and-gait-analyses-for-the-functional-performance-of%C3%A2-a%C3%A2-custom-made-total-talonavicular-replacement
#4
Claudio Belvedere, Matteo Cadossi, Antonio Mazzotti, Sandro Giannini, Alberto Leardini
The present study evaluated the restoration of joint function in a special clinical case: a professional rock climber who underwent an original total talonavicular replacement with a custom-made prosthesis after a complex articular fracture. Full body gait analysis and 3-dimensional joint kinematics using single-plane fluoroscopy were performed on the same day at the 30-month follow-up examination. Gait analysis was performed using stereophotogrammetric, dynamometric, electromyographic, and baropodometric systems...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28633148/clinical-and-functional-results-of-119-patients-with-knee-dislocations
#5
Nicholas R Scarcella, Douglas S Weinberg, Stephen Bowen, Heather A Vallier
OBJECTIVES: To describe clinical results and functional outcomes of knee dislocations treated with a consistent strategy within our institution. DESIGN: Retrospective case series. SETTING: Level 1 trauma center. PATIENTS: One hundred nineteen patients were treated at one institution between 2000 and 2014 for knee dislocation. MAIN OUTCOME MEASUREMENTS: Knee range of motion, functional instability, and complications were recorded...
July 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28632524/callosal-motor-impersistence-a-novel-disconnection-syndrome
#6
Hee Jin Kim, Dongyeop Kim, Da-Heen Won, Juhee Chin, Kwang Ho Lee, Sang Won Seo, Kenneth M Heilman, Duk L Na
Motor impersistence, an inability to sustain a certain position or movement, is a motor-intentional disorder, caused more often by right than left hemisphere lesions. Since the right hemisphere is dominant for mediating motor persistence, callosal lesions that disconnect the left hemisphere from the right may induce impersistence of the right upper and lower limbs. After an undiagnosed left callosal infarction, a 65-year-old right-handed man suddenly developed a transient loss of volitional movement of his left leg...
June 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28631216/safety-and-tolerability-of-empagliflozin-in-patients-with-type-2-diabetes-pooled-analysis-of-phase-i-iii-clinical-trials
#7
Sven Kohler, Cordula Zeller, Hristo Iliev, Stefan Kaspers
INTRODUCTION: We characterized the safety and tolerability of empagliflozin in patients with type 2 diabetes (T2DM) randomized 1:1:1 to placebo, empagliflozin 10 mg, or empagliflozin 25 mg in clinical trials. METHODS: Pooled data were analyzed from patients with T2DM treated with placebo (N = 4203), empagliflozin 10 mg (N = 4221), or empagliflozin 25 mg (N = 4196) in 15 randomized phase I-III trials plus four extension studies. Adverse events (AEs) were assessed descriptively in participants who took at least one dose of study drug...
June 19, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28630841/bipolar-hemiarthroplasty-in-a-patient-with-above-knee-amputation-surgical-technique
#8
Ramesh Perumal, Santhosh Ram Gaddam, J Vasudeva, J Dheenadhayalan, S Rajasekaran
INTRODUCTION: Femoral neck fractures are a common occurrence in lower limb amputees. Good post-operative results of hip hemiarthroplasty have been described in below-knee amputees. However, to our knowledge, very few such cases have been reported in above-knee amputees. CASE REPORT: We present a case of a 75-year-old male patient who underwent above-knee amputation of the right lower limb for severe crush injury right leg and a bipolar hemiarthroplasty for an ipsilateral fracture neck of femur sustained in the same road traffic accident...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28630829/are-we-justified-doing-salvage-or-amputation-procedure-based-on-mangled-extremity-severity-score-in-mangled-upper-extremity-injury
#9
R Siva Kumar, Prahalad Kumar Singhi, M Chidambaram
INTRODUCTION: Mangled upper limb injuries are at surge because of industrialization, modernization, and severe motor vehicle accidents. The utility of various scoring systems are meant for decision making in mangled lower limb injuries, and the same have been extrapolated for mangled upper limb injuries to make a decision of salvage or amputation for the lack of separate scoring system. MATERIALS AND METHODS: We applied mangled extremity severity score (MESS) and mangled extremity syndrome index (MESI) scoring systems to 10 cases of mangled upper limb injuries during the period of November 2010 to September 2012 presented at our tertiary trauma care center...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28630762/articular-impaction-injuries-in-the-lower-limb
#10
Ippokratis Pountos, Peter V Giannoudis
The effective management of articular impacted fractures requires the successful elevation of the osteochondral fragment to eliminate joint incongruency and the stable fixation of the fragments providing structural support to the articular surface.The anatomical restoration of the joint can be performed either with elevation through a cortical window, through balloon-guided osteoplasty or direct visualisation of the articular surface.Structural support of the void created in the subchondral area can be achieved through the use of bone graft materials (autologous tricortical bone), or synthetic bone graft substitutes...
May 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28630584/time-loss-injuries-in-sub-elite-and-emerging-rugby-league-players
#11
Mark Booth, Rhonda Orr
This study aimed to 1) investigate the incidence and characteristics of injuries in emerging rugby league players; and 2) explore the differences in injury incidence and characteristics between the various sub-elite competitions. An NRL emerging player development squad (n = 34) was observed from the beginning of pre-season until the finish of competition. Time-loss injury was defined as any physical pain or impairment sustained that resulted in players missing a match. Injuries were categorised according to circumstance, incidence, characteristics, playing position and competition level...
June 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28629353/lipid-emulsion-mitigates-impaired-pulmonary-function-induced-by-limb-ischemia-reperfusion-in-rats-through-attenuation-of-local-cellular-injury-and-the-subsequent-systemic-inflammatory
#12
Fangfang Xia, Yun Xia, Sisi Chen, Lulu Chen, Weijuan Zhu, Yuanqing Chen, Thomas J Papadimos, Xuzhong Xu, Le Liu
BACKGROUND: Limb ischemia/reperfusion causes inflammation and elicits oxidative stress that may lead to local tissue damage and remote organ such as lung injury. This study investigates pulmonary function after limb ischemia/reperfusion and the protective effect of a lipid emulsion (Intralipid). METHODS: Twenty-four rats were divided into three groups: sham operation group (group S), ischemia/reperfusion group (group IR), and lipid emulsion treatment group (group LE)...
June 19, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28624711/does-the-powers%C3%A2-strap-influence-the-lower-limb-biomechanics-during-running
#13
Henrike Greuel, Lee Herrington, Anmin Liu, Richard K Jones
Previous research has reported a prevalence of running related injuries in 25.9% to 72% of all runners. A greater hip internal rotation and adduction during the stance phase in running has been associated with many running related injuries, such as patellofemoral pain. Researchers in the USA designed a treatment device 'the Powers™ strap' to facilitate an external rotation of the femur and to thereby control abnormal hip and knee motion during leisure and sport activities. However, to date no literature exists to demonstrate whether the Powers™ strap is able to reduce hip internal rotation during running...
June 3, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28623105/transfer-of-the-lateral-antebrachial-cutaneous-nerve-to-the-dorsal-branch-of-the-ulnar-nerve-without-nerve-graft-in-case-of-lower-brachial-plexus-injuries-anatomical-and-feasibility-study
#14
J Pauchot, U Assouline, S Valmary-Degano, B Constantinou, L Obert, D Lepage
In the context of lower (C8-T1) brachial plexus injury, transfer of the lateral antebrachial cutaneous nerve (LABCN) to the dorsal branch of the ulnar nerve (DBUN) with an interposed sural nerve graft has been proposed to restore sensitivity on the ulnar side of the hand. The purpose of this study was to assess the feasibility of performing this transfer directly - without interposition of a nerve graft - by intraneural dissection of the DBUN. An anatomical study was performed with 20 upper limbs from adult human cadavers...
June 13, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28623098/acquired-inhibition-of-microrna-124-protects-against-spinal-cord-ischemia-reperfusion-injury-partially-through-a-mitophagy-dependent-pathway
#15
Kun Liu, Lihui Yan, Xiaojing Jiang, Yang Yu, Hongbo Liu, Tianxiang Gu, Enyi Shi
OBJECTIVE: Mitophagy results in selective clearance of damaged mitochondria. We investigated whether mitophagy was involved in the neuroprotection by inhibiting microRNA (miRNA)-124 on ischemic spinal cords. METHODS: Inhibition of miRNA-124 was conducted by intrathecal injection of lentivirus vectors containing antagomiR-124. Spinal cord ischemia was induced in rats by crossclamping the descending aorta just distal to the left subclavian artery for 14 minutes. Hind-limb motor function was assessed with the motor deficit index (MDI)...
May 23, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28619087/longitudinal-estimation-of-intramuscular-tibialis-anterior-coherence-during-subacute-spinal-cord-injury-relationship-with-neurophysiological-functional-and-clinical-outcome-measures
#16
Elisabeth Bravo-Esteban, Julian Taylor, Manuel Aleixandre, Cristina Simón-Martínez, Diego Torricelli, Jose Luis Pons, Gerardo Avila-Martín, Iriana Galán-Arriero, Julio Gómez-Soriano
BACKGROUND: Estimation of surface intramuscular coherence has been used to indirectly assess pyramidal tract activity following spinal cord injury (SCI), especially within the 15-30 Hz bandwidth. However, change in higher frequency (>40 Hz) muscle coherence during SCI has not been characterised. Thus, the objective of this study was to identify change of high and low frequency intramuscular Tibialis Anterior (TA) coherence during incomplete subacute SCI. METHODS: Fifteen healthy subjects and 22 subjects with motor incomplete SCI (American Spinal Injury Association Impairment Scale, AIS, C or D grade) were recruited and tested during 4 sessions performed at 2-week intervals up to 8 months after SCI...
June 15, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28618311/predicting-knee-osteoarthritis-risk-in-injured-populations
#17
Michael J Long, Enrica Papi, Lynsey D Duffell, Alison H McGregor
BACKGROUND: Individuals who suffered a lower limb injury have an increased risk of developing knee osteoarthritis. Early diagnosis of osteoarthritis and the ability to track its progression is challenging. This study aimed to explore links between self-reported knee osteoarthritis outcome scores and biomechanical gait parameters, whether self-reported outcome scores could predict gait abnormalities characteristic of knee osteoarthritis in injured populations and, whether scores and biomechanical outcomes were related to osteoarthritis severity via Spearman's correlation coefficient...
June 12, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28617522/factors-related-to-successful-return-to-work-following-multidisciplinary-rehabilitation
#18
Halimah Awang, Lih Yoong Tan, Norma Mansor, Phattrawan Tongkumchum, Mayuening Eso
OBJECTIVE: To examine factors associated with successful return to work among participants in a Social Security Organisation Return To Work programme. METHODS: Secondary data for 9,850 participants were obtained from the Social Security Organisation Return To Work database. The dependent variable was the Return To Work programme outcome, successful return to employment (same employer or different employer) or unsuccessful return. Logistic regression analysis with weighted sum contrasts was performed to assess the odds ratios with 95% confidence interval (95% CI) for successful return to employment across the various subgroups of participants...
June 8, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28616040/stem-cell-transplantation-for-spinal-cord-injury-a-meta-analysis-of-treatment-effectiveness-and-safety
#19
Xiao Fan, Jin-Zhao Wang, Xiao-Min Lin, Li Zhang
OBJECTIVE: The aim of this study was to evaluate the effectiveness and safety of stem cell transplantation for spinal cord injury (SCI). DATA SOURCES: PubMed, EMBASE, Cochrane, China National Knowledge Infrastructure, China Science and Technology Journal, Wanfang, and SinoMed databases were systematically searched by computer to select clinical randomized controlled trials using stem cell transplantation to treat SCI, published between each database initiation and July 2016...
May 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28614149/ota-classification-is-highly-predictive-of-acute-compartment-syndrome-following-tibia-fracture-a-cohort-of-2885-fractures
#20
Michael J Beebe, Darryl Auston, Jonathan Quade, Rafael Serrano-Riera, Anjan Shah, David Watson, Roy Sanders, Hassan Mir
OBJECTIVE: To determine the correlation between the OTA classification of tibia fractures and the development of acute compartment syndrome (ACS). DESIGN: Retrospective review of prospectively collected database SETTING:: Single level 1 academic trauma center PATIENTS:: All patients with a tibia fracture from 2006 to 2016. 3606 fractures were initially identified. Skeletally mature patients with plate or intramedullary fixation managed from initial injury through definitive fixation at our institution were included, leaving 2885 fractures in 2778 patients...
May 23, 2017: Journal of Orthopaedic Trauma
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