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https://www.readbyqxmd.com/read/29792368/electrophysiological-multimodal-assessments-improve-outcome-prediction-in-traumatic-cervical-spinal-cord-injury
#1
Markus Hupp, Chiara Pavese, Lucas Bachmann, Rene Koller, Martin Schubert
Outcome prediction after spinal cord injury (SCI) is essential for early counseling and orientation of the rehabilitative intervention. Moreover, prognostication of outcome is crucial to achieve meaningful stratification when conceiving clinical trials. Neurophysiological examinations are commonly employed for prognostication after SCI, but whether neurophysiology could improve the functional prognosis based on clinical predictors remains open. Data of 224 patients included in the European Multicenter Study about Spinal Cord Injury were analyzed with bootstrapping analysis and multivariate logistic regression to derive prediction models of complete functional recovery in chronic stage after traumatic cervical SCI...
May 24, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29791941/understanding-refugees-health
#2
Martin Müller, Dana Khamis, David Srivastava, Aristomenis K Exadaktylos, Carmen Andrea Pfortmueller
According to the United Nations Refugee Agency (UNHCR), 65.6 million people have been forcibly displaced worldwide. Several factors have a major influence on asylum seekers' health; so, their health profile is markedly different from that of the population in the country of asylum. The aim of this study is to review the major issues physicians need to be aware of when treating asylum seekers, with a special focus on the neurological problems of asylum seekers and refugees. The major impact factors on refugees' health are linked to experiences and exposure (1) in the country of origin, (2) in refugee camps and en route to Europe, and (3) in the process of immigration into the host country and living in European asylum centers...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29791302/preferences-of-adults-with-spinal-cord-injury-for-widely-used-health-related-quality-of-life-and-subjective-well-being-measures
#3
Alina Ionela Palimaru, William E Cunningham, Marcus Dillistone, Arturo Vargas-Bustamante, Honghu Liu, Ron D Hays
OBJECTIVE: To describe preferences for survey instruments on health-related quality of life (HRQOL) and subjective well-being (SWB) among adults with spinal cord injury (SCI), and compare perspectives on the instruments between the United States and the United Kingdom. DESIGN: We conducted 20 in-depth interviews. SETTING: Participants were interviewed in their homes, some in person and some via Skype. PARTICIPANTS: A convenience sample of 20 adults with SCI (10 in the US and 10 in the UK) were recruited via print and on-line advertisements...
May 23, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29790404/clinical-and-neurophysiological-changes-after-targeted-intrathecal-injections-of-bone-marrow-stem-cells-in-a-c3-tetraplegic-subject
#4
Andrea Jimena Santamaria, Francisco D Benavides, Darcy L DiFede, Aisha Khan, Marietsy V Pujol, W Dalton Dietrich, Antonio Marttos, Barth A Green, Joshua M Hare, James Guest
High-level quadriplegia is a devastating condition with limited treatment options. Bone marrow derived stem cells (BMSCs) are reported to have immunomodulatory and neurotrophic effects in spinal cord injury (SCI). We report a subject with complete C2 SCI who received 3 anatomically targeted intrathecal infusions of BMSCs under a single-patient expanded access IND. She underwent intensive physical therapy and was followed for over 2 years. At end-point, her AIS grade improved from A to B and she recovered focal pressure touch sensation over several body areas...
May 23, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29790403/the-amelioration-of-pain-related-behavior-in-mice-with-chronic-spinal-cord-injury-treated-with-neural-stem-progenitor-cell-transplantation-combined-with-treadmill-training
#5
Syoichi Tashiro, Soraya Nishimura, Munehisa Shinozaki, Morito Takano, Tsunehiko Konomi, Osahiko Tsuji, Narihito Nagoshi, Yoshiaki Toyama, Meigen Liu, Hideyuki Okano, Masaya Nakamura
Progress in regenerative medicine is realizing the possibility of neural regeneration and functional recovery in spinal cord injury (SCI). Recently, rehabilitation has attracted much attention in respect to the synergistic promotion of functional recovery in combination with neural stem/progenitor cell (NS/PC) transplantation, even in the chronic refractory phase of SCI. Nevertheless, sensory disturbance is one of the most prominent sequelae, even though the effects of combination or single therapies have been investigated almost only in the context of motor recovery...
May 23, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29790098/three-step-method-for-transesophageal-echocardiography-guided-implantation-of-the-frozen-elephant-trunk-how-to-prevent-spinal-cord-injury
#6
Kazuo Yamanaka, Hisanari Ishii
Total aortic arch replacement using the frozen elephant trunk (FET) procedure has widely spread all over the world with more sophisticated devices. However, spinal cord injury is one of the most important complications, which limits the use of FET. In our hospital, 80 patients treated with FET had no spinal cord injury. There are three key points to avoid spinal cord injury, (1) The distal end of stent graft should be positioned up to the eighth thoracic vertebrae level; (2) the time for selective left subclavian artery perfusion and distal body circulatory arrest should be shortened within 60 min; and (3) mean blood pressure should be maintained above 70 mmHg...
May 22, 2018: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29790067/receptor-for-advanced-glycation-end-products-rage-blockade-do-damage-to-neuronal-survival-via-disrupting-wnt-%C3%AE-catenin-signaling-in-spinal-cord-injury
#7
Hongyu Wang, Ziming Zhao, Chang Liu, Zhanpeng Guo, Yajiang Yuan, Haoshen Zhao, Zipeng Zhou, Xifan Mei
Wnt signaling are recognized key factors in neuronal development, cell proliferation and axonal guidance. However, RAGE effect on wnt signaling after spinal cord injury (SCI) are poorly understood. Our study aims to explore RAGE blockade effect on wnt signaling after SCI. We constructed Allen SCI model and micro-injected with RAGE neutralizing antibody or IgG after injury. We determined β-catenin, wnt3a and its receptor frizzled-5 via Western blot. We determined β-catenin/NeuN expression at 2 weeks after SCI via immunofluorescence (IF)...
May 22, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29789707/the-natural-course-of-passive-tenodesis-grip-in-individuals-with-spinal-cord-injury-with-preserved-wrist-extension-power-but-paralyzed-fingers-and-thumbs
#8
Hae Yoon Jung, Jieun Lee, Hyung Ik Shin
STUDY DESIGN: Cross-sectional. OBJECTIVES: To investigate the natural course of passive tenodesis grip in individuals with spinal cord injury (SCI) with no experience of tenodesis splint application and the related factors for success of the grip. SETTING: Community-dwelling persons with chronic SCI in South Korea. METHODS: Individuals with cervical SCI with preserved wrist extensor power, but completely paralyzed fingers and thumbs, were recruited...
May 22, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29789705/the-short-term-effect-of-ultrasound-and-peripheral-nerve-stimulator-guided-femoral-nerve-block-with-phenol-on-the-outcomes-of-patients-with-traumatic-spinal-cord-injury
#9
Yasin Demir, Ayça Uran Şan, Serdar Kesikburun, Evren Yaşar, Bilge Yılmaz
STUDY DESIGN: A pre-post descriptive study. OBJECTIVES: To examine the immediate effects of ultrasound-guided femoral nerve block with phenol (UGFNBwP) in managing the lower limb spasticity of individuals with traumatic spinal cord injury (SCI). SETTING: Ankara, Turkey. METHODS: Nineteen patients with traumatic SCI presenting with lower extremity spasticity were treated with UGFNBwP. Modified Ashworth Scale of hip flexion and knee extension, functional independence measure motor subscale, difficulty of catheterization, hygiene score, spasm frequency, sleep quality, and patient satisfaction (PS) were measured in all patients prior to treatment, in the first week and second month...
May 22, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29789089/-gz-exposure-and-spinal-injury-induced-flight-duty-limitations
#10
Tuomas Honkanen, Roope Sovelius, Matti Mäntysaari, Heikki Kyröläinen, Janne Avela, Tuomo K Leino
BACKGROUND: The present study aimed to find out if possible differences in early military flight career +Gz exposure level could predict permanent flight duty limitations (FDL) due to spinal disorders during a pilot's career. METHODS: The study population consisted of 23 pilots flying with Gz limitation (max limitation ranging from +2 Gz to +5 Gz) due to spinal disorders and 50 experienced (+1000 flight hours) symptomless controls flying actively in operative missions in the Finnish Air Force...
June 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29788960/ecto-5-nucleotidase-cd73-attenuates-inflammation-after-spinal-cord-injury-by-promoting-macrophages-microglia-m2-polarization-in-mice
#11
Shun Xu, Wei Zhu, Minghao Shao, Fan Zhang, Ji Guo, Haocheng Xu, Jianyuan Jiang, Xiaosheng Ma, Xinlei Xia, Xiuling Zhi, Ping Zhou, Feizhou Lu
BACKGROUND: Immune activation, specifically activation of macrophages and resident microglia, leading to inflammation is a key component in the progression of spinal cord injury (SCI). Macrophages/microglia exist in two states-the classically activated M1 phenotype that confers pro-inflammatory effects or the alternatively activated M2 phenotype that confers anti-inflammatory effects. Ecto-5'-nucleotidase (CD73) is an immunosuppressive molecule intricately involved in adaptive and innate immune responses and is able to dephosphorylate AMP to adenosine...
May 22, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29788868/contribution-of-spinal-cord-oligodendrocytes-to-neuroinflammatory-diseases-and-pain
#12
Sergio M Borghi, Victor Fattori, Miriam S N Hohmann, Waldiceu A Verri
BACKGROUND: Neuroinflammatory diseases that affect spinal cord or associated spinal nerves represent challenging conditions for management in current medicine because of their complex pathology, poor prognosis, and high morbidity, which strikingly reduces the quality of life of patients. In this sense, a better understanding of the cellular and molecular mechanisms of spinal cord neuroinflammation might contribute to the development of novel therapies. Oligodendrocytes have unique and vital biological properties in central nervous system (CNS) homeostasis and physiology...
May 21, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29787880/comparison-of-surgical-invasiveness-between-microdiscectomy-and-three-different-endoscopic-discectomy-techniques-for-lumbar-disc-herniation
#13
Kyung-Chul Choi, Hyeong-Ki Shim, Jin-Sup Hwang, Seung Ho Shin, Dong Chan Lee, Hwan Hui Jung, Hyeon Ah Park, Choon-Keun Park
OBJECTIVE: Muscle injury is inevitable during surgical exposure of the spine. This study was conducted to investigate paraspinal muscle injury after the following four surgical techniques: microdiscectomy (MD), percutaneous endoscopic lumbar discectomy (PELD), percutaneous endoscopic interlaminar discectomy (PEID), and unilateral biportal endoscopic discectomy (UBED). METHODS: Eighty patients who underwent the four surgical techniques were prospectively observed...
May 19, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29787876/risk-analysis-based-on-the-timing-of-tracheostomy-procedures-in-patients-with-spinal-cord-injury-requiring-cervical-spine-surgery
#14
Rita Galeiras, Mónica Mourelo, María Teresa Bouza, María Teresa Seoane, María Elena Ferreiro, Antonio Montoto, Sebastián Salvador, Leticia Seoane, David Freire
INTRODUCTION: To determine the optimal moment to carry out a tracheostomy in a patient requiring anterior cervical fixation. METHODS: A retrospective observational study was carried out over an 18-year period on 56 patients who had been admitted to the ICU with acute spinal cord injury (SCI), and who underwent a tracheostomy and surgical fixation. The sample was divided into two groups: An at-risk group (31 patients, who had undergone a tracheostomy prior to the cervical surgery or <4 days after the procedure), and a not at-risk group (25 patients, who had undergone a tracheostomy >4 day following the fixation surgery)...
May 19, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29787874/ancient-observation-of-spinal-cord-injury-the-case-of-the-assiryan-lion
#15
REVIEW
Gustavo J Luvizutto, Emerson G Siqueira, Pedro Tadao Hamamoto Filho, Viviane F Zétola, Marcos C Lange, Hélio A Theive, Luiz A Resende, Rodrigo Bazan
The description of paraplegia is considered a milestone in the history of neurology. The Egyptians provided excellent descriptions of spinal cord injuries, the Bible has several references to paraplegia, and, more recently, the pioneers of neurology described the classic syndromes related to spinal injuries and paraplegia. Here, we describe an ancient observation by the Assyrian people of paraplegia in an animal. In ancient Assyria, lion hunting was a ritualized activity conducted for political and religious purposes...
May 19, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29787691/the-influence-of-spinal-cord-injury-on-breastfeeding-ability-and-behavior
#16
Theodor Holmgren, Amanda H X Lee, Shea Hocaloski, Lynsey J Hamilton, Iris Hellsing, Stacy Elliott, Claes Hultling, Andrei V Krassioukov
BACKGROUND: Lactation dysfunction following spinal cord injury has been noted in the literature. However, researchers have often grouped together all women of physical disability or do not account for injury level. The extent of lactation dysfunction and influence of spinal cord injury on breastfeeding ability and behavior is not well understood. Research aim: This study aimed to identify major barriers to lactation and breastfeeding related to spinal cord injury, specifically comparing high- and low-level injuries...
May 1, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29787541/validation-of-predictive-equations-to-assess-energy-expenditure-in-acute-spinal-cord-injury
#17
Christine L Ramirez, Stacy Pelekhaty, Jennifer M Massetti, Samuel Galvagno, Laura Harmon, Isadora Botwinick, Thomas M Scalea, Deborah M Stein
BACKGROUND: Acute spinal cord injury (SCI) is devastating with morbidities compounded by inadequate nutrition. The American Society for Parenteral and Enteral Nutrition recommends indirect calorimetry (IC) to evaluate energy needs in SCI because no predictive energy equations have been validated. We sought to determine the accuracy of predictive equations to predict measured energy expenditure (MEE). METHODS: A retrospective review was performed over 2 years. Patients 18 years or older with cervical SCI who received IC were included...
April 30, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29787329/sensitivity-to-change-and-responsiveness-of-the-segmental-assessment-of-trunk-control-satco-in-children-with-spinal-cord-injury
#18
Laura C Argetsinger, Shelley A Trimble, MacKenzie T Roberts, Jennifer E Thompson, Beatrice Ugiliweneza, Andrea L Behrman
PURPOSE: The purpose of this study was to assess the sensitivity and responsiveness of the Segmental Assessment of Trunk Control (SATCo) for evaluating trunk control in children with spinal cord injury (SCI) receiving activity-based locomotor training (AB-LT). METHODS: Prospective study of nine outcomes for consecutively enrolled children in outpatient AB-LT. To evaluate sensitivity to change, linear-mixed models were constructed and adjusted for covariates: age at and time since SCI...
May 22, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29786472/high-speed-fluoroscopy-used-to-measure-dynamic-spinal-cord-deformation-in-an-in-vivo-rat-model
#19
Erin Lucas, Tom Whyte, Jie Liu, Colin M Russell, Wolfram Tetzlaff, Peter Alec Cripton
While spinal cord deformation is thought to be a predictor of spinal cord injury severity, few researchers have directly investigated the dynamic cord deformation or distribution of the deformation between white and grey matter of the in vivo spinal cord during impact. This knowledge would help to establish correlations among impact parameters, internal spinal cord deformation, and histological and functional outcomes. Relying on surface deformations alone may not be a sufficient representation of spinal cord deformation...
May 22, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29786465/trunk-stability-enabled-by-non-invasive-spinal-electrical-stimulation-after-spinal-cord-injury
#20
Mrinal Rath, Albert H Vette, Shyamsundar Ramasubramaniam, Kun Li, Joel Burdick, Victor Reggie Edgerton, Yury Gerasimenko, Dimitry Sayenko
Electrical neuromodulation of spinal networks improves the control of movement of the paralyzed limbs after spinal cord injury (SCI). However, the potential of non-invasive spinal stimulation to facilitate postural trunk control during sitting in humans with SCI has not been investigated. We hypothesized that transcutaneous electrical stimulation of the lumbosacral enlargement can improve trunk posture. Eight participants with non-progressive SCI, C3-T9, AIS A or C, performed different motor tasks during sitting...
May 22, 2018: Journal of Neurotrauma
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