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JOURNAL ARTICLE
Yoonyoung Jang, Taehwa Kim, Yunsu Choi, Kyoung Hwan Ahn, Jung Ho Kim, Hye Seong, Youn Jeong Kim, Shin-Woo Kim, Jun Yong Choi, Hyo Youl Kim, Joon Young Song, Hee Jung Choi, Sang Il Kim, Jang Wook Sohn, BumSik Chin, Bo-Youl Choi, Boyoung Park
INTRODUCTION: This study aimed to investigate the association between obesity and cancer risk as well as site-specific cancer risks in adults with HIV using a nationwide health screening database in Korea. METHODS: Of the 16,671 adults with a new diagnosis of HIV from 2004 to 2020, 456 incident cancer cases and 1,814 individually matched controls by sex, year of birth, year of HIV diagnosis, and follow-up duration (1:4 ratio) were included in this nested case-control study...
April 10, 2024: AIDS
#22
JOURNAL ARTICLE
Margaux Vienne, Charlène Lopez, Hubert Lulka, Adèle Nevot, Guillaume Labrousse, Nelson Dusetti, Louis Buscail, Pierre Cordelier
Pancreatic cancer will soon become the second cause of death by cancer in Western countries. The main barrier to increase the survival of patients with this disease requires the development of novel and efficient therapeutic strategies that better consider tumor biology. In this context, oncolytic viruses emerge as promising therapeutics. Among them, the fibrotropic minute virus of mice prototype (MVMp) preferentially infects migrating and undifferentiated cells that highly resemble poorly differentiated, basal-like pancreatic tumors showing the worst clinical outcome...
March 21, 2024: Mol Ther Oncol
#23
JOURNAL ARTICLE
Jun Li, Jingyan Gao, Min Huang, Xiaoyun Fu, Bao Fu
AIM: To compare the clinical characteristics of survival and nonsurvival patients with severe acute pancreatitis (SAP) and explore the risk of mortality in SAP patients. METHODS: This was a single-center retrospective study performed in a severe acute pancreatitis diagnosis and treatment center. According to the outcome, SAP patients were divided into survival group and nonsurvival group. One-way ANOVA or independent t -test was used to compare the clinical characteristics of two groups of patients...
2024: Gastroenterology Research and Practice
#24
REVIEW
Anne Marie Sowerbutts, Sorrel Burden, Jana Sremanakova, Chloe French, Stephen R Knight, Ewen M Harrison
BACKGROUND: Poor preoperative nutritional status has been consistently linked to an increase in postoperative complications and worse surgical outcomes. We updated a review first published in 2012. OBJECTIVES: To assess the effects of preoperative nutritional therapy compared to usual care in people undergoing gastrointestinal surgery. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, three other databases and two trial registries on 28 March 2023...
April 8, 2024: Cochrane Database of Systematic Reviews
#25
JOURNAL ARTICLE
Francisco Josué Cordero Pérez, Eva P Martín-Garrido, Marta Antona-Herranz, Carmen Bailador-Andrés, Pilar Conde-Gacho, Clara de Diego-Cobos, Santiago J Rodriguez-Gomez
BACKGROUND: This report presents the influence of immunosuppression by new rheumatological therapies on hepatitis E virus infection in a 54-year-old male patient with an anti-synthetase syndrome and treatment with methotrexate and rituximab. CASE DESCRIPTION: The patient arrived at the Emergency Department with epigastric pain, vomiting and dark urine. Initial examination revealed signs of inflammation and hepatic dysfunction. Subsequent laboratory tests and imaging confirmed acute hepatitis E infection in the context of recent initiation of rituximab therapy...
2024: European Journal of Case Reports in Internal Medicine
#26
JOURNAL ARTICLE
Ramy Behman, Rebecca C Auer, Lev Bubis, Grace Xu, Natalie G Coburn, Guillaume Martel, Julie Hallet, Fady Balaa, Calvin Law, Kimberly A Bertens, Jad Abou Khalil, Paul Jack Karanicolas
INTRODUCTION: Surgical stress results in immune dysfunction, predisposing patients to infections in the postoperative period and potentially increasing the risk of cancer recurrence. Perioperative immunonutrition with arginine-enhanced diets has been found to potentially improve short-term and cancer outcomes. This study seeks to measure the impact of perioperative immunomodulation on biomarkers of the immune response and perioperative outcomes following hepatopancreaticobiliary surgery...
April 5, 2024: BMJ Open
#27
JOURNAL ARTICLE
Maki Takahashi, Tomohisa Ishida, Sakirul Khan, Ryosuke Makino, Mark A Cline, Tetsuya Tachibana
Nitric oxide (NO) is gaseous bioactive molecule that is synthesized by NO synthase (NOS). Inducible NOS (iNOS) expression occurs in response to pathogenic challenges, resulting in the production of large amounts of NO. However, there is a lack of knowledge regarding neuronal NOS (nNOS) and endothelial NOS (eNOS) in birds during pathogenic challenge. Therefore, the present study was conducted to determine the influence of intraperitoneal (IP) injection of zymosan (cell wall component of yeast) and lipopolysaccharide (LPS, a cell wall component of gram-negative bacteria) on NOS expression in chicks (Gallus gallus)...
April 2, 2024: Veterinary Immunology and Immunopathology
#28
REVIEW
Mark Ayoub, Julton Tomanguillo, Carol Faris, Nadeem Anwar, Harleen Chela, Ebubekir Daglilar
Previous studies showed a potential anti-inflammatory effect of proton pump inhibitors (PPI) as well as possible inhibition of pancreatic secretion. This presents the question of their possible use in acute pancreatitis (AP). Current clinical evidence does not address the role of PPI and the present review for possible therapeutic use and safety is lacking. Therefore, our study aims to address the role of PPI in the management of AP and their association with the different outcomes of AP. We queried the Diamond Network through TriNetX-Research Network...
April 5, 2024: Medicine (Baltimore)
#29
JOURNAL ARTICLE
Mamoru Ito, Yuta Okumura, Kenta Nio, Eishi Baba, Yukinori Ozaki, Hiroshi Nishio, Eiki Ichihara, Yuji Miura, Makoto Endo, Shingo Yano, Dai Maruyama, Tetsuhiro Yoshinami, Nobuyuki Susumu, Munetaka Takekuma, Takashi Motohashi, Nobuaki Ochi, Toshio Kubo, Keita Uchino, Takahiro Kimura, Yutaro Kamiyama, Shinji Nakao, Shinobu Tamura, Hitomi Nishimoto, Yasuhisa Kato, Atsushi Sato, Toshimi Takano, Kenji Tsuchihashi
BACKGROUND: Granulocyte colony-stimulating factor (G-CSF) reportedly reduces the risk of neutropenia and subsequent infections caused by cancer chemotherapy. Although several guidelines recommend using G-CSF in primary prophylaxis according to the incidence rate of chemotherapy-induced febrile neutropenia (FN), the effectiveness of G-CSF in digestive system tumor chemotherapy remains unclear. To address these clinical questions, we conducted a systematic review as part of revising the Clinical Practice Guidelines for the Use of G-CSF 2022 published by the Japan Society of Clinical Oncology...
April 5, 2024: International Journal of Clinical Oncology
#30
EDITORIAL
Cheng Lv, Zi-Xiong Zhang, Lu Ke
Approximately 20%-30% of patients with acute necrotizing pancreatitis develop infected pancreatic necrosis (IPN), a highly morbid and potentially lethal complication. Early identification of patients at high risk of IPN may facilitate appropriate preventive measures to improve clinical outcomes. In the past two decades, several markers and predictive tools have been proposed and evaluated for this purpose. Conventional biomarkers like C-reactive protein, procalcitonin, lymphocyte count, interleukin-6, and interleukin-8, and newly developed biomarkers like angiopoietin-2 all showed significant association with IPN...
March 7, 2024: World Journal of Gastroenterology: WJG
#31
JOURNAL ARTICLE
He-Xing Hang, Zheng-Hua Cai, Yi-Fei Yang, Xu Fu, Yu-Dong Qiu, Hao Cheng
BACKGROUND: Radical surgery combined with systemic chemotherapy offers the possibility of long-term survival or even cure for patients with pancreatic ductal adenocarcinoma (PDAC), although tumor recurrence, especially locally, still inhibits the treatment efficacy. The TRIANGLE technique was introduced as an extended dissection procedure to improve the R0 resection rate of borderline resectable or locally advanced PDAC. However, there was a lack of studies concerning postoperative complications and long-term outcomes of this procedure on patients with resectable PDAC...
March 27, 2024: World Journal of Gastrointestinal Surgery
#32
JOURNAL ARTICLE
Xiao-Yan Liu, Hong-Nian Pan, Yue Yu
BACKGROUND: Advanced pancreatic cancer is resistant to chemotherapeutic drugs, resulting in limited treatment efficacy and poor prognosis. Combined administration of the chemotherapeutic gemcitabine and erlotinib is considered a potential first-line treatment for advanced pancreatic cancer. However, their comparative benefits and potential risks remain unclear. AIM: To assess the clinical efficacy and safety of erlotinib combined with other chemotherapy regimens for the treatment of advanced pancreatic cancer...
March 27, 2024: World Journal of Gastrointestinal Surgery
#33
REVIEW
Akbar Hussain, Sana W Augustine, Sandhya Pyakurel, Hemika Vempalli, Rishika Dabbara, Rachel A O'dare, Ayush, Jeffrin John Varghese, Pugazhendi Inban, Malavika Jayan, Elsie Chizaram Osigwe, Sindhu Meghana Sunkara, Aadil Khan
Acute pancreatitis, marked by sudden inflammation of the pancreas, presents a complex spectrum of causative factors including gallstone obstruction, alcohol abuse, and viral infections. Recent studies have illuminated the emergence of vaccine-induced acute pancreatitis, notably associated with COVID-19 vaccinations, presenting diverse mechanisms ranging from direct viral-mediated injury to autoimmune reactions. Understanding this link is pivotal for public health, yet challenges persist in identifying and managing cases post-vaccination...
March 2024: Curēus
#34
JOURNAL ARTICLE
Anouk M L H Emmen, Maurice J W Zwart, Igor E Khatkov, Ugo Boggi, Bas Groot Koerkamp, Olivier R Busch, Olivier Saint-Marc, Safi Dokmak, I Quintus Molenaar, Mathieu D'Hondt, Marco Ramera, Tobias Keck, Giovanni Ferrari, Misha D P Luyer, Luca Moraldi, Benedetto Ielpo, Uwe Wittel, Francois-Regis Souche, Thilo Hackert, Daan Lips, Mehmet Fatih Can, Koop Bosscha, Regis Fara, Sebastiaan Festen, Susan van Dieren, Andrea Coratti, Ignace De Hingh, Michele Mazzola, Ulrich Wellner, Celine De Meyere, Hjalmar C van Santvoort, Béatrice Aussilhou, Abdallah Ibenkhayat, Roeland F de Wilde, Emanuele F Kauffmann, Pavel Tyutyunnik, Marc G Besselink, Mohammad Abu Hilal
BACKGROUND: The use of robot-assisted and laparoscopic pancreatoduodenectomy is increasing, yet large adjusted analyses that can be generalized internationally are lacking. This study aimed to compare outcomes after robot-assisted pancreatoduodenectomy and laparoscopic pancreatoduodenectomy in a pan-European cohort. METHODS: An international multicenter retrospective study including patients after robot-assisted pancreatoduodenectomy and laparoscopic pancreatoduodenectomy from 50 centers in 12 European countries (2009-2020)...
April 2, 2024: Surgery
#35
REVIEW
Da Wang, Jingyao Ren, Yuanyuan Wang, Xiaohua Dong, Shuo Liu, Tianyi Liao, Lihui Zhu, Miao Yu, Hui Cai
BACKGROUND: There is an ongoing debate regarding the comparative merits of splenectomy (SP) and splenic preservation in the surgical management of gastric cancer. This systematic review and meta-analysis aims to shed light on potential differences in survival outcomes and postoperative complications associated with these two procedures. METHOD: An exhaustive literature search was conducted across multiple databases, namely PubMed, Embase, Cochrane Library, and Web of Science...
April 3, 2024: Postgraduate Medicine
#36
JOURNAL ARTICLE
Nao Kitasaki, Tomoyuki Abe, Masashi Inoue, Marino Teshima, Masataka Nakagawa, Masatoshi Kochi, Ryuichi Hotta, Kazuhiro Toyota
BACKGROUND: Pancreatic adenosquamous cell carcinoma (PASC) is a relatively rare histological type of pancreatic malignancy, and preoperative diagnosis is difficult because of its rarity. PASC accounts for 1-4% of all pancreatic cancers, and even after curative surgery, its prognosis is poorer than that of ordinary pancreatic adenocarcinoma. Pathologically, it shows glandular and squamous differentiation of cells. Complete resection is the only method to achieve a good long-term prognosis, and an increasing doubling time of PASC is considered to indicate early recurrence after surgery...
April 1, 2024: Surgical Case Reports
#37
JOURNAL ARTICLE
Shu-Fan Li, Ji-Wei Xu, Gao-Min Liu, Hua-Dong Zeng
In patients with severe necrotizing pancreatitis, pancreatic necrosis and secondary infection of surrounding tissues can quickly spread to the whole retroperitoneal space. Treatment of pancreatic abscess complicating necrotizing pancreatitis is difficult and has a high mortality rate. The well-accepted treatment strategy is early debridement of necrotic tissues, drainage, and postoperative continuous retroperitoneal lavage. However, traditional open surgery has several disadvantages, such as severe trauma, interference with abdominal organs, a high rate of postoperative infection and adhesion, and hardness with repeated debridement...
March 15, 2024: Journal of Visualized Experiments: JoVE
#38
JOURNAL ARTICLE
Teng-Yuan Hou, Andrzej L Komorowski, Tsan-Shiun Lin, Yu-Cheng Lin, Yi-Ping Sng, Cheng-Hsi Yeh, Wei-Feng Li, Chih-Che Lin, Chih-Chi Wang
BACKGROUND: Uncontrolled massive bleeding and bowel edema are critical issues during liver transplantation. Temporal intra-abdominal packing with staged biliary reconstruction (SBR) yields acceptable outcomes in deceased donor liver transplantation; however, data on living donor liver transplantation (LDLT) are scarce. METHODS: A retrospective analysis of 1269 patients who underwent LDLT was performed. After one-to-two propensity score matching, patients who underwent LDLT with SBR were compared with those who underwent LDLT with one-stage biliary reconstruction (OSBR)...
March 20, 2024: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
#39
JOURNAL ARTICLE
Abdullah S Madhun, Egil Karlsbakk, Øystein Skaala, Monica F Solberg, Vidar Wennevik, Alison Harvey, Sonnich Meier, Per T Fjeldheim, Kaja Christine Andersen, Kevin A Glover
Disease interactions between farmed and wild populations have been poorly documented for most aquaculture species, in part due to the complexities to study this. Here, we tested 567 farmed Atlantic salmon escapees, captured in a Norwegian river during 2014-2018, for five viral infections that are prevalent in global salmonid aquaculture. Over 90% of the escapees were infected with one or more viruses. Overall prevalences were: 75.7% for piscine orthoreovirus (PRV-1), 43.6% for salmonid alphavirus (SAV), 31...
March 31, 2024: Journal of Fish Diseases
#40
JOURNAL ARTICLE
Aitor Blanco-Míguez, Sara Carloni, Cindy Cardenas, Carola Conca Dioguardi, Luca Lambroia, Giovanni Capretti, Gennaro Nappo, Alessandro Fugazza, Antonio Capogreco, Federica Armanini, Francesco Asnicar, Leonard Dubois, Davide Golzato, Paolo Manghi, Federica Pinto, Cristina Scuderi, Erminia Casari, Marco Montorsi, Andrea Anderloni, Maria Rescigno, Alessandro Repici, Alessandro Zerbi, Clelia Peano, Sabrina Tamburini, Roberto Rusconi, Nicola Segata
Malignant bile duct obstruction is typically treated by biliary stenting, which however increases the risk of bacterial infections. Here, we analyzed the microbial content of the biliary stents from 56 patients finding widespread microbial colonization. Seventeen of 36 prevalent stent species are common oral microbiome members, associate with disease conditions when present in the gut, and include dozens of biofilm- and antimicrobial resistance-related genes. This work provides an overview of the microbial communities populating the stents...
March 30, 2024: NPJ Biofilms and Microbiomes
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