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infections in pancreatitis

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https://www.readbyqxmd.com/read/29906644/retroperitoneal-versus-open-intraperitoneal-necrosectomy-in-step-up-therapy-for-infected-necrotizing-pancreatitis-a-meta-analysis
#1
REVIEW
Yun-Bing Wang, Xiao-Li Yang, Long Chen, Zheng-Ju Chen, Chun-Mu Miao, Jin Xia
BACKGROUND: Step-up therapy is the recommended therapy for infected necrotizing pancreatitis (INP). However, the most appropriate secondary therapy for use after initial drainage has not been fully determined. This meta-analysis was designed to evaluate the efficacy and safety of retroperitoneal versus open intraperitoneal necrosectomy as part of a step-up strategy for INP. MATERIALS AND METHODS: Eight online databases were searched for randomized controlled trials (RCTs) and cohorts comparing retroperitoneal and open intraperitoneal step-up approaches for treating INP...
June 12, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29903511/non-inferiority-of-open-passive-drains-compared-with-closed-suction-drains-in-pancreatic-surgery-outcomes-a-prospective-observational-study
#2
Giovanni Marchegiani, Giampaolo Perri, Alessandra Pulvirenti, Elisabetta Sereni, Anna Maria Azzini, Giuseppe Malleo, Roberto Salvia, Claudio Bassi
BACKGROUND: Policies concerning the management of operatively placed drains after pancreatic surgery are still under debate. Open passive drains and closed-suction drains are both used currently in clinical practice worldwide, but there are no reliable data regarding potential differences in the postoperative outcomes associated with each drain type. The aim of the present study was to compare open passive drains and closed-suction drains with regard to postoperative contamination of the drainage fluid and overall morbidity and mortality...
June 11, 2018: Surgery
https://www.readbyqxmd.com/read/29895577/marantic-endocarditis-incidental-infarcts-leading-to-diagnosis-of-pancreatic-cancer
#3
Ella Starobinska, Eric A Robinson, Eric Brucks, Serena Scott
Non-bacterial thrombotic endocarditis (NBTE) is a well-described phenomenon associated with malignancies due to hypercoaguable state. In the setting of pancreatic cancer, NBTE is more commonly diagnosed postmortem. We describe a case of a man who was diagnosed with pancreatic carcinoma after incidental finding of NBTE. Imaging incidentally revealed multiple strokes, bilateral renal and splenic infarcts, while subsequent workup for cardioembolic source demonstrated a 1.1×0.7 cm mitral valve vegetation. As multiple blood cultures were sterile and patient lacked clinical signs of infection, an underlying malignancy was suspected...
June 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29891102/risk-factors-for-infectious-pancreatic-necrosis-in-farmed-chilean-atlantic-salmon-salmo-salar-l-from-2010-to-2013
#4
J Escobar-Dodero, A Kinsley, A M Perez, R Ibarra, A Tello, G Monti, F O Mardones
Infectious pancreatic necrosis (IPN) is a widespread and economically devastating fish disease caused by infection with a virus referred to as IPN virus (IPNv). In Chile, the disease is endemic and prevalent in both fresh- and salt-water farms affecting cultured salmonids, mainly Atlantic salmon. Here, we present the results of a retrospective cohort study of Atlantic salmon farms stocked between 2010 and 2013, aimed at quantifying the extent to which certain epidemiological factors influence the time interval between stocking and onset of IPN mortality (time to mortality, ttm) in marine farms...
April 25, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29890547/a-novel-c-125-t-g-p-val42gly-mutation-in-the-human-ins-gene-leads-to-neonatal-diabetes-mellitus-via-a-decrease-in-insulin-synthesis
#5
Fei Sun, Wenhua Du, Junhua Ma, Mingjun Gu, Jingnan Wang, Hongling Zhu, Huaidong Song, Guanqi Gao
BACKGROUND: Neonatal diabetes mellitus is likely caused by monogenic mutations, several of which have been identified. INS mutations have a broad spectrum of clinical presentations, ranging from severe neonatal onset to mild adult onset, which suggests that the products of different mutant INS alleles behave differently and utilize distinct mechanisms to induce diabetes. In this study, a neonatal diabetes mellitus patient's INS gene was sequenced, and functional experiments were conducted...
June 11, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29890300/application-of-pancreaticojejunostomy-with-one-layer-suture-in-pancreaticoduodenectomy-a-retrospective-cohort-study
#6
Chong Zhong Liu, Jian Kang Zhu, Qianqian Xu, Feng Yue Liu, Ya Dong Wang, Min Zhu
BACKGROUND: Postoperative pancreatic fistula (POPF) is the most common critical complication after pancreaticoduodenectomy (PD) and a primary reason for increased mortality and morbidity after PD. To perform a safe pancreaticojejunostomy (PJ), a fast and simple technique of duct-to-mucosa PJ with one-layer suture was devised at our institution. MATERIALS AND METHODS: We conducted a retrospective analysis of 81 successive cases of PD performed at our hospital from March 2012 to August 2016...
June 8, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29887705/outcome-of-pancreaticoduodenectomy-at-low-volume-centre-in-tier-ii-city-of-india
#7
Kumar Vinchurkar, Vishwanath M Pattanshetti, Manoj Togale, Santosh Hazare, Varadraj Gokak
Currently, pancreaticoduodenectomy (PD) is considered a common and feasibly performed surgery for periampullary tumours, but it is still a high-risk surgical procedure with potential morbidity and mortality rates. Previously, it was emphasised for the need of high-volume centres to perform specialised surgery such as PD. The authors have made an attempt to know the relation between low-volume centre and outcomes of PD. The study was conducted in a Tier-II city referral hospital located in Karnataka, India. A total of 37 patients with suspected periampullary neoplasms underwent surgical exploration with curative intent over a period of 4 years, i...
June 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29887694/32-consecutive-cases-of-whipple-s-operation-with-single-layer-end-to-side-dunking-pancreatojejunostomy-without-any-pancreatic-fistula-our-institutional-experience
#8
Ashutosh Gupta, Sourabh Nandi, Santanu Tiwari, Amit Choraria, Vivek Chaudhary
The aim of this paper is to study the outcome of single-layer end to side dunking pancreatojejunostomy technique in 32 patients of malignant pancreatic disease undergoing Whipple's surgery in a tertiary care oncology centre in India. From January 2013 to January 2016, 32 consecutive patients who underwent pancreatoduodenectomy for malignant diseases were analysed retrospectively. All the patients underwent standard Whipple's operation. Pancreatojejunostomy was established in a single-layer end to side dunking manner with PDS 4-0...
June 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29886024/ivacaftor-treatment-of-cystic-fibrosis-in-children-aged-12-to-24-months-and-with-a-cftr-gating-mutation-arrival-a-phase-3-single-arm-study
#9
Margaret Rosenfeld, Claire E Wainwright, Mark Higgins, Linda T Wang, Charlotte McKee, Daniel Campbell, Simon Tian, Jennifer Schneider, Steve Cunningham, Jane C Davies
BACKGROUND: Ivacaftor is generally safe and effective in patients aged 2 years and older who have cystic fibrosis and specific CFTR mutations. We assessed its use in children aged 12 to <24 months. METHODS: The ARRIVAL study is a phase 3, single-arm, two-part, multicentre study. Eligible children were aged 12 to <24 months at enrolment and had a confirmed diagnosis of cystic fibrosis and a CFTR gating mutation on at least one allele and could participate in one or both parts of the study...
June 6, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29883474/causes-of-death-in-patients-with-berardinelli-seip-congenital-generalized-lipodystrophy
#10
Josivan Gomes Lima, Lucia Helena C Nobrega, Natalia Nobrega Lima, Marcel Catão Ferreira Dos Santos, Pedro Henrique Dantas Silva, Maria de Fatima P Baracho, Debora Nobrega Lima, Julliane Tamara Araújo de Melo Campos, Leonardo Capistrano Ferreira, Francisco Paulo Freire Neto, Carolina de O Mendes-Aguiar, Selma Maria B Jeronimo
INTRODUCTION: Berardinelli-Seip Congenital Lipodystrophy (BSCL) is a rare autosomal recessive disease that affects the development of adipocytes and leads to an inability to store fat in adipocytes. This study aimed to evaluate the life expectancy and the causes of death of patients with BSCL. METHOD: We analyzed death certificates, and medical records of BSCL patients who died between 1997 and 2017. If the death certificate was incomplete or unavailable, we reviewed the medical records, and if they were not available too, we collected information from the patient's relatives to understand how the death happened...
2018: PloS One
https://www.readbyqxmd.com/read/29879176/changes-of-mody-signal-pathway-genes-in-the-endoplasmic-reticulum-stress-in-ins-1-3-cells
#11
Yanan Dong, Shirui Li, Wenhui Zhao, Yanlei Wang, Tingting Ge, Jianzhong Xiao, Yukun Li
OBJECTIVE: Metabolic disturbances induce endoplasmic reticulum stress (ERS) in pancreatic beta cells. This study aims to investigate whether a common pathway exists in the ERS induced by various chemicals, including high levels of glucose and palmitate in INS-1-3 cells. METHOD: ERS in INS-1-3 cells was induced by exposure cells to thapsigargin (TG), tunicamycin (TM) or palmitic acid (PA) +high glucose (HG). Digital gene expression (DGE) profiling technique was used to detect differentially expressed genes...
2018: PloS One
https://www.readbyqxmd.com/read/29876048/dilated-cardiomyopathy-secondary-to-acute-pancreatitis-caused-by-hypertriglyceridemia
#12
Jordan W Greer, William C Beck, Avi Bhavaraju, Ben Davis, Mary K Kimbrough, Joseph Jensen, Anna Privratsky, Ronald Robertson, John R Taylor, Kevin W Sexton
A 30-year-old male presented to an outside facility with acute pancreatitis and triglycerides of 1594. He was transferred to our facility after becoming febrile, hypoxic and in acute renal failure with triglycerides of 4243. CT scan performed showed wall-off pancreatic necrosis. He underwent continuous renal replacement therapy and his acute renal failure resolved. He was treated with broad spectrum antibiotics and discharged. He developed a fever to 101 a week later and was found to have a large infected pancreatic pseudocyst...
May 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29870031/endosonography%C3%A2-guided-treatment-of-a-large-infected-pseudocyst-sustained-after-posttraumatic-acute-pancreatitis-in-a-critically-ill-patient
#13
Łukasz Krupa, Joanna Lorenc, Robert Staroń, Mariusz Partyka, Łukasz Chmielarz, Krzysztof Gutkowski
No abstract text is available yet for this article.
May 30, 2018: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29868513/gr-1-cells-other-than-ly6g-neutrophils-limit-virus-replication-and-promote-myocardial-inflammation-and-fibrosis-following-coxsackievirus-b3-infection-of-mice
#14
Dan Xu, Peijie Wang, Jie Yang, Qian Qian, Min Li, Lin Wei, Wei Xu
Coxsackievirus B3 (CVB3) is the primary cause of viral myocarditis. An early and abundant neutrophil accumulation in the myocardium is a hallmark of early CVB3 infection. Yet the relative contribution of neutrophils to host susceptibility to CVB3 myocarditis remains largely unknown. Herein, peripheral neutrophil depletion was implemented in a BALB/c mouse model of acute CVB3 myocarditis using the specific 1A-8 (anti-Ly6G) or a RB6-8C5 (anti-Gr-1) mAb covering a wide range. Anti-Ly6G treatment led to systemic neutropenia throughout the disease, but did not alter virus replication, disease susceptibility and histopathological changes in the heart and pancreas of mice...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29863131/surgical-outcomes-of-laparoscopic-distal-gastrectomy-compared-to-open-distal-gastrectomy-a-retrospective-cohort-study-based-on-a-nationwide-registry-database-in-japan
#15
Kazuhiro Yoshida, Michitaka Honda, Hiraku Kumamaru, Yasuhiro Kodera, Yoshihiro Kakeji, Naoki Hiki, Tsuyoshi Etoh, Hiroaki Miyata, Yuichi Yamashita, Yasuyuki Seto, Seigo Kitano, Hiroyuki Konno
To clarify the safety profile of laparoscopic distal gastrectomy (LDG) for gastric cancer patients, the short-term outcome of LDG was compared to that of open distal gastrectomy (ODG) by propensity score matching using data from the Japanese National Clinical Database (NCD). We conducted a retrospective cohort study of patients undergoing distal gastrectomy between January 2012 and December 2013. Using the data for 70 346 patients registered in the NCD, incidences of mortality and morbidities were compared between LDG patients and ODG patients in the propensity score matched stage I patients (ODG: n = 14 386, LDG: n = 14 386) and stage II-IV patients (ODG: n = 3738, LDG: n = 3738), respectively...
January 2018: Annals of gastroenterological surgery
https://www.readbyqxmd.com/read/29808141/an-extremely-rapid-case-of-pneumonitis-with-the-use-of-nivolumab-for-pancreatic-adenocarcinoma
#16
Rubens Barros Costa, Al Benson, Vahid Yaghmai, Ricardo L B Costa, Haijun Zhou, Amir Behdad, Jason B Kaplan, Maureen Sadim, Sarah Talamantes, Aparna Kalyan
Pancreatic cancer is the fourth most common cancer death in the United States despite comprising a small percentage of the total number of cancer cases. The estimated 5-year overall survival (OS) for patients with distant metastatic disease is approximately 3%. New treatment options are an unmet need and remain an area of active investigation. A 53-year-old male with metastatic pancreatic cancer presented to the hospital with acute-on-chronic respiratory failure approximately 24 hours after receiving a novel therapeutic combination...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29806129/infectious-pancreatic-necrosis-virus-isolated-from-farmed-rainbow-trout-and-tilapia-in-kenya-is-identical-to-european-isolates
#17
I R Mulei, P N Nyaga, P G Mbuthia, R M Waruiru, L W Njagi, E W Mwihia, A A A Gamil, Ø Evensen, S Mutoloki
Infectious pancreatic necrosis virus (IPNV) is an aquabirnavirus that causes serious diseases in a variety of fish species worldwide. It has been isolated from a large number of healthy fresh and marine water fish. Prior to this study, there was no record of the presence of IPNV infection in Kenya. Here, the presence of IPNV in farmed rainbow trout and tilapia was examined in Nyeri County of central Kenya. Head kidney samples taken from five rainbow trout and three tilapia farms and stored in RNALater® were processed by PCR followed by sequencing of a segment A fragment covering nucleotide positions 2,120-2,343 bp...
May 28, 2018: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29803829/no-evidence-for-presence-of-mait-cells-in-the-insulitic-lesions-in-patients-recently-diagnosed-with-type-1-diabetes
#18
Enida Kuric, Lars Krogvold, Kristian F Hanssen, Knut Dahl-Jørgensen, Oskar Skog, Olle Korsgren
Mucosal-associated invariant T (MAIT) cells are innate T cells that recognize bacteria-infected cells and are thought to play a role in autoimmune diseases. Translocation of duodenal bacteria and viruses to the pancreas through the pancreatic duct has been hypothesized to initiate an innate inflammatory response that could contribute to the development of type 1 diabetes, a process that could involve MAIT cells. In this study, we used immunohistochemistry and qPCR to search for evidence of MAIT cells in the insulitic lesions in the pancreas of human patients recently diagnosed with type 1 diabetes...
May 24, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29802078/the-role-of-extra-pancreatic-infections-in-the-prediction-of-severity-and-local-complications-in-acute-pancreatitis
#19
Elizabeth Pando, Piero Alberti, Jimmy Hidalgo, Laura Vidal, Cristina Dopazo, Mireia Caralt, Laia Blanco, Concepción Gómez-Gavara, Itxarone Bilbao, Joaquim Balsells, Ramon Charco
BACKGROUND: The aim of our study was to determine the risk factors for extrapancreatic infection (EPI) occurrence and its predictive power for assessing severity and local complications in acute pancreatitis including infected pancreatic necrosis (IPN). METHODS: Clinical data of 176 AP patients prospectively enrolled were analysed. EPI analysed were bacteraemia, lung infection, urinary tract infection and catheter line infection. Risk factors analysed were: Leukocyte count, C-reactive protein, liver function test, serum calcium, serum glucose, Blood urea nitrogen, mean arterial pressure at admission, total parenteral nutrition (TPN), enteral nutrition, hypotension, respiratory, cardiovascular and renal failure at admission, persistent systemic inflammatory response (SIRS) and intrapancreatic necrosis...
May 19, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29798841/nardilysin-inhibits-pancreatitis-and-suppresses-pancreatic-ductal-adenocarcinoma-initiation-in-mice
#20
Kozo Ikuta, Akihisa Fukuda, Satoshi Ogawa, Kenji Masuo, Norihiro Goto, Yukiko Hiramatsu, Motoyuki Tsuda, Yoshito Kimura, Yoshihide Matsumoto, Yuto Kimura, Takahisa Maruno, Keitaro Kanda, Kiyoto Nishi, Kyoichi Takaori, Shinji Uemoto, Shigeo Takaishi, Tsutomu Chiba, Eiichiro Nishi, Hiroshi Seno
OBJECTIVE: Nardilysin (NRDC), a zinc peptidase, exhibits multiple localisation-dependent functions including as an enhancer of ectodomain shedding in the extracellular space and a transcriptional coregulator in the nucleus. In this study, we investigated its functional role in exocrine pancreatic development, homeostasis and the formation of pancreatic ductal adenocarcinoma (PDA). DESIGN: We analysed Ptf1a-Cre; Nrdcflox/flox mice to investigate the impact of Nrdc deletion...
May 24, 2018: Gut
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