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https://www.readbyqxmd.com/read/28334724/incidence-of-multiple-sclerosis-in-puerto-rico-2014-a-population-based-study
#1
Angel Chinea, Carlos F Ríos-Bedoya, Cristina Rubi, Ivonne Vicente, Eduardo R Estades, Yatzka G Hernandez-Silvestrini
BACKGROUND: Multiple sclerosis (MS) affects millions of people worldwide. The estimates for MS incidence are difficult to obtain but are important for understanding MS etiology, developing prevention strategies, and service planning. This study is aimed at estimating the 2014 incidence of MS in Puerto Rico (PR). METHODS: The PR MS Foundation's registry was used as the data source. Neurologists, specialty pharmacies, MRI centers, health insurance companies, and the PR Department of Health identified MS cases missed by the registry...
March 24, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/28301287/spinal-cord-lesions-a-modest-contributor-to-diagnosis-in-clinically-isolated-syndromes-but-a-relevant-prognostic-factor
#2
Georgina Arrambide, Alex Rovira, Jaume Sastre-Garriga, Carmen Tur, Joaquín Castilló, Jordi Río, Angela Vidal-Jordana, Ingrid Galán, Breogán Rodríguez-Acevedo, Luciana Midaglia, Carlos Nos, Patricia Mulero, Maria Jesús Arévalo, Manuel Comabella, Elena Huerga, Cristina Auger, Xavier Montalban, Mar Tintore
BACKGROUND: The usefulness of performing a spinal cord (SC) magnetic resonance imaging (MRI) in all clinically isolated syndromes (CIS) is controversial. OBJECTIVE: To assess the value of SC lesions for predicting multiple sclerosis (MS) diagnosis and disability accrual in CIS. METHODS: Concerning SC lesions and MS diagnosis (2010 McDonald), adjusted Cox regression analyses were performed in increasingly specific CIS groups: all cases ( n = 207), non-SC CIS ( n = 143), non-SC CIS with abnormal brain MRI ( n = 90) and non-SC CIS with abnormal brain MRI not fulfilling 2010 MS ( n = 67)...
March 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28301243/development-of-multilocus-sequence-typing-mlst-for-mycoplasma-synoviae
#3
Mohamed El-Gazzar, Mostafa Ghanem, Kristina McDonald, Naola Ferguson-Noel, Ziv Raviv, Richard D Slemons
Mycoplasma synoviae (MS) is a poultry pathogen that has had an increasing incidence and economic impact over the past few years. Strain identification is necessary for outbreak investigation, infection source identification, and facilitating prevention and control as well as eradication efforts. Currently, a segment of the variable lipoprotein hemagglutinin A (vlhA) gene (420 bp) is the only target that is used for MS strain identification. A major limitation of this assay is that colonality of typed samples can only be inferred if their vlhA sequences are identical; however, if their sequences are different, the degree of relatedness is uncertain...
March 2017: Avian Diseases
https://www.readbyqxmd.com/read/28285265/neuropsychiatric-syndromes-of-multiple-sclerosis
#4
REVIEW
Ruth Murphy, Stefani O'Donoghue, Timothy Counihan, Colm McDonald, Peter A Calabresi, Mohammed As Ahmed, Adam Kaplin, Brian Hallahan
Neuropsychiatric signs and symptoms occur frequently in individuals with multiple sclerosis (MS), either as the initial presenting complaint prior to a definitive neurological diagnosis or more commonly with disease progression. However, the pathogenesis of these comorbid conditions remains unclear and it remains difficult to accurately elucidate if neuropsychiatric symptoms or conditions are indicators of MS illness severity. Furthermore, both the disease process and the treatments of MS can adversely impact an individual's mental health...
March 11, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28283103/there-is-less-mri-brain-lesions-and-no-characteristic-mri-brain-findings-in-iidds-patients-with-positive-aqp4-serology-among-malaysians
#5
Suhailah Abdullah, Farhana Fadzli, Norlisah Ramli, Chong Tin Tan
BACKGROUND AND OBJECTIVE: The recently introduced International Consensus diagnostic criteria for diagnosis of neuromyelitis spectrum disorder include patients who are seronegative for AQP4 antibody. The criteria are dependent on typical MRI changes in the spinal cord, optic nerve and brain. This study aims to determine whether there are significant differences in the MRI brain images between AQP4 positive and negative patients with IIDDs. METHOD: MRI brain of patients with a diagnosis of IIDDs presented to the Hospital from 2010 to 2015 was analysed...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28252605/-autonomic-dysfunction-in-patients-with-multiple-sclerosis
#6
A R Rakhmatullin, K Z Bakhtiiarova, R V Magzhanov
AIM: To optimize the early diagnosis of the autonomic dysfunction in patients with MS. MATERIAL AND METHODS: The main group consisted of 46 patients: 15 men and 31 women with MS (McDonald, 2005), the average age was 33.35±9.9 years, the average score of the Expanded disability scale (EDSS) was 2.8±1.17 points. The control group consisted of 24 healthy subjects matched by age and sex with the main group. A study of the autonomic nervous system was carried out using the Scheme for detection of signs of autonomic disorders (A...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28218939/assessment-of-factors-for-recruiting-and-retaining-medical-students-to-rural-communities-using-the-community-apgar-questionnaire
#7
Alex J Reed, David Schmitz, Edward Baker, James Girvan, Theodore McDonald
BACKGROUND: Rural communities throughout the United States are eager to recruit and retain family physicians. This study examined factors that may contribute to a medical student's decision to consider rural family medicine practice using the Community Apgar Questionnaire (CAQ). METHODS: Third- and fourth-year medical students from 10 medical schools responded to a survey of 62 identified factors deemed to be present when assessing the strengths and challenges of recruiting family physicians to rural communities...
February 2017: Family Medicine
https://www.readbyqxmd.com/read/28210898/flow-cytometric-analysis-reveals-the-high-levels-of-platelet-activation-parameters-in-circulation-of-multiple-sclerosis-patients
#8
Agnieszka Morel, Joanna Rywaniak, Michał Bijak, Elżbieta Miller, Marta Niwald, Joanna Saluk
The epidemiological studies confirm an increased risk of cardiovascular disease in multiple sclerosis, especially prothrombotic events directly associated with abnormal platelet activity. The aim of our study was to investigate the level of blood platelet activation in the circulation of patients with chronic phase of multiple sclerosis (SP MS) and their reactivity in response to typical platelets' physiological agonists. We examined 85 SP MS patients diagnosed according to the revised McDonald's criteria and 50 healthy volunteers as a control group...
February 16, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28150498/flavonoid-metabolites-in-human-urine-during-blueberry-anthocyanin-intake
#9
Wilhelmina Kalt, Jane E McDonald, Yan Liu, Sherry A E Fillmore
The human health benefits of anthocyanins (Anc) and other flavonoids are widely recognized. However, the flavonoid-based urinary metabolites arising in vivo after Anc intake are not well described. Human (n = 17) urine was collected while blueberry juice (BJ) was consumed daily for 28 days and once after a 7 day washout. MS/MS scanning of 664 urine samples for 18 parent Anc (PAnc) and 42 predicted Anc metabolites (AncM) yielded 371 products (i.e., MS/MS × retention time (RT)). Flavonoid-based AncM, which were likely underestimated, were almost 20 times more abundant than PAnc...
March 1, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28114441/assessment-of-early-evidence-of-multiple-sclerosis-in-a-prospective-study-of-asymptomatic-high-risk-family-members
#10
Zongqi Xia, Sonya U Steele, Anshika Bakshi, Sarah R Clarkson, Charles C White, Matthew K Schindler, Govind Nair, Blake E Dewey, Lauren R Price, Joan Ohayon, Lori B Chibnik, Irene C M Cortese, Philip L De Jager, Daniel S Reich
Importance: Subclinical inflammatory demyelination and neurodegeneration often precede symptom onset in multiple sclerosis (MS). Objective: To investigate the prevalence of brain magnetic resonance imaging (MRI) and subclinical abnormalities among asymptomatic individuals at risk for MS. Design, Setting, and Participants: The Genes and Environment in Multiple Sclerosis (GEMS) project is a prospective cohort study of first-degree relatives of people with MS...
March 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28107447/a-software-tool-for-estimation-of-burden-of-infectious-diseases-in-europe-using-incidence-based-disability-adjusted-life-years
#11
Edoardo Colzani, Alessandro Cassini, Daniel Lewandowski, Marie-Josee J Mangen, Dietrich Plass, Scott A McDonald, Alies van Lier, Juanita A Haagsma, Guido Maringhini, Alessandro Pini, Piotr Kramarz, Mirjam E Kretzschmar
The burden of disease framework facilitates the assessment of the health impact of diseases through the use of summary measures of population health such as Disability-Adjusted Life Years (DALYs). However, calculating, interpreting and communicating the results of studies using this methodology poses a challenge. The aim of the Burden of Communicable Disease in Europe (BCoDE) project is to summarize the impact of communicable disease in the European Union and European Economic Area Member States (EU/EEA MS)...
2017: PloS One
https://www.readbyqxmd.com/read/28092018/bladder-dysfunction-in-multiple-sclerosis-a-6-year-follow-up-study
#12
Darija Kisic Tepavcevic, Tatjana Pekmezovic, Irena Dujmovic Basuroski, Sarlota Mesaros, Jelena Drulovic
Bladder dysfunction (BD) is the most common autonomic disturbance in multiple sclerosis, but often overlooked and undertreated. The purpose of this longitudinal study was to explore the changes in the frequency of BD symptoms in MS cohort after a period of 3 and 6 years of follow-up, as well as to investigate the correlations between the presence of BD symptoms and both clinical characteristics and the health-related quality of life (HRQoL) at each subsequent point of estimation. The study population comprises a cohort of 93 patients with MS (McDonald's criteria, 2001)...
March 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28039317/subcutaneous-interferon-%C3%AE-1a-in-the-treatment-of-clinically-isolated-syndromes-3-year-and-5-year-results-of-the-phase-iii-dosing-frequency-blind-multicentre-reflexion-study
#13
Giancarlo Comi, Nicola De Stefano, Mark S Freedman, Frederik Barkhof, Bernard M J Uitdehaag, Marlieke de Vos, Kurt Marhardt, Liang Chen, Delphine Issard, Ludwig Kappos
OBJECTIVE: Early treatment following a first clinical demyelinating event (FCDE) delays further disease activity in patients with multiple sclerosis (MS). This study determined the effects of early versus delayed treatment (DT) with subcutaneous interferon (sc IFN) β-1a 44 μg in patients with an FCDE up to 60 months postrandomisation. METHODS: Patients who completed the 24-month double-blind REFLEX (REbif FLEXible dosing in early MS) study entered an extension (REFLEXION, REbif FLEXible dosing in early MS extensION): patients initially randomised to sc IFN β-1a and not reaching clinically definite MS (clinically definite MS, CDMS (second attack or sustained Expanded Disability Status Scale (EDSS) score increase)) continued original treatment (three times weekly (tiw) or once weekly (qw)); placebo patients switched to tiw (DT); patients with CDMS switched to tiw...
April 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27919474/a-study-of-cognitive-fatigue-in-multiple-sclerosis-with-novel-clinical-and-electrophysiological-parameters-utilizing-the-event-related-potential-p300
#14
Somasundaram Aadhimoolam Chinnadurai, Srinivasan Avathvadi Venkatesan, Gobinathan Shankar, Balasubramanian Samivel, Lakshmi Narasimhan Ranganathan
BACKGROUND: Although cognitive fatigue plays a significant part in Multiple Sclerosis (MS) related impairment, knowledge regarding it is largely lacking. Until now, not many tools are available to a clinician to detect cognitive fatigue. The subjective tools of fatigue have never been reliable.tabl OBJECTIVES: To assess the prevalence and clinical/ demographic profile of cognitive fatigue in MS using novel clinical and electrophysiological measures and to find their accuracy. We also aimed to test the three leading hypotheses - the temporal fatigue, cognitive load and cognitive domain hypotheses of cognitive fatigue in MS...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27911122/an-update-on-the-use-of-cerebrospinal-fluid-analysis-as-a-diagnostic-tool-in-multiple-sclerosis
#15
Matteo Gastaldi, Elisabetta Zardini, Diego Franciotta
Intrathecal B-lymphocyte activation is a hallmark of multiple sclerosis (MS), a multi-factorial inflammatory-demyelinating disease of the central nervous system. Such activation has a counterpart in the cerebrospinal fluid (CSF) oligoclonal IgG bands (OCB), whose diagnostic role in MS has been downgraded within the current McDonald's criteria. With a theoretico-practical approach, the authors review the physiopathological basis of the CSF dynamics, and the state-of-the-art of routine CSF analysis and CSF biomarkers in MS...
January 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27793206/mog-igg-in-nmo-and-related-disorders-a-multicenter-study-of-50-patients-part-2-epidemiology-clinical-presentation-radiological-and-laboratory-features-treatment-responses-and-long-term-outcome
#16
Sven Jarius, Klemens Ruprecht, Ingo Kleiter, Nadja Borisow, Nasrin Asgari, Kalliopi Pitarokoili, Florence Pache, Oliver Stich, Lena-Alexandra Beume, Martin W Hümmert, Marius Ringelstein, Corinna Trebst, Alexander Winkelmann, Alexander Schwarz, Mathias Buttmann, Hanna Zimmermann, Joseph Kuchling, Diego Franciotta, Marco Capobianco, Eberhard Siebert, Carsten Lukas, Mirjam Korporal-Kuhnke, Jürgen Haas, Kai Fechner, Alexander U Brandt, Kathrin Schanda, Orhan Aktas, Friedemann Paul, Markus Reindl, Brigitte Wildemann
BACKGROUND: A subset of patients with neuromyelitis optica spectrum disorders (NMOSD) has been shown to be seropositive for myelin oligodendrocyte glycoprotein antibodies (MOG-IgG). OBJECTIVE: To describe the epidemiological, clinical, radiological, cerebrospinal fluid (CSF), and electrophysiological features of a large cohort of MOG-IgG-positive patients with optic neuritis (ON) and/or myelitis (n = 50) as well as attack and long-term treatment outcomes. METHODS: Retrospective multicenter study...
September 27, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27773545/cadasil-mimicking-multiple-sclerosis-the-importance-of-clinical-and-mri-red-flags
#17
Stuti Joshi, Wayne Yau, Allan Kermode
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited small vessel disease, manifesting as recurrent ischaemic events, migraine with aura, behavioural disturbance and cognitive decline. We report two patients with CADASIL masquerading as multiple sclerosis (MS). A 23year old female presented with a visual scotoma and was discovered to have a corresponding retinal cotton wool spot. MRI brain revealed diffuse T2 hyperintensities suggestive of demyelination...
January 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27756768/linc-maf-4-regulates-th1-th2-differentiation-and-is-associated-with-the-pathogenesis-of-multiple-sclerosis-by-targeting-maf
#18
Fang Zhang, Guiyou Liu, Changjuan Wei, Chao Gao, Junwei Hao
In this study, we strove to substantiate the ability of linc-MAF-4 to act as a regulator of pathogenesis during multiple sclerosis (MS). We recruited 34 patients who were diagnosed with MS according to the revised McDonald Criteria. Six patients with MS and 5 healthy volunteers contributed peripheral blood mononuclear cells for microarray analysis. Subsequent knockdown and overexpression of linc-MAF-4 in naive CD4(+) T cells from the additional 28 patients with MS was performed to track changes in CD4(+) T-cell subsets and their function as well as to confirm results from the prior microarray analysis...
October 18, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27741559/the-arc-of-mass-spectrometry-exchange-formats-is-long-but-it-bends-toward-hdf5
#19
Manor Askenazi, Hisham Ben Hamidane, Johannes Graumann
The evolution of data exchange in Mass Spectrometry spans decades and has ranged from human-readable text files representing individual scans or collections thereof (McDonald et al., 2004) through the official standard XML-based (Harold, Means, & Udemadu, 2005) data interchange standard (Deutsch, 2012), to increasingly compressed (Teleman et al., 2014) variants of this standard sometimes requiring purely binary adjunct files (Römpp et al., 2011). While the desire to maintain even partial human readability is understandable, the inherent mismatch between XML's textual and irregular format relative to the numeric and highly regular nature of actual spectral data, along with the explosive growth in dataset scales and the resulting need for efficient (binary and indexed) access has led to a phenomenon referred to as "technical drift" (Davis, 2013)...
October 14, 2016: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/27730374/importance-of-cerebrospinal-fluid-analysis-in-the-era-of-mcdonald-2010-criteria-a-german-austrian-retrospective-multicenter-study-in-patients-with-a-clinically-isolated-syndrome
#20
André M Huss, Steffen Halbgebauer, Patrick Öckl, Corinna Trebst, Annette Spreer, Nadja Borisow, Andrea Harrer, Isabel Brecht, Bettina Balint, Oliver Stich, Sabine Schlegel, Nele Retzlaff, Alexander Winkelmann, Romy Roesler, Florian Lauda, Özlem Yildiz, Elke Voß, Rainer Muche, Sebastian Rauer, Florian Then Bergh, Markus Otto, Friedemann Paul, Brigitte Wildemann, Jörg Kraus, Klemens Ruprecht, Martin Stangel, Mathias Buttmann, Uwe K Zettl, Hayrettin Tumani
The majority of patients presenting with a first clinical symptom suggestive of multiple sclerosis (MS) do not fulfill the MRI criteria for dissemination in space and time according to the 2010 revision of the McDonald diagnostic criteria for MS and are thus classified as clinically isolated syndrome (CIS). To re-evaluate the utility of cerebrospinal fluid (CSF) analysis in the context of the revised McDonald criteria from 2010, we conducted a retrospective multicenter study aimed at determining the prevalence and predictive value of oligoclonal IgG bands (OCBs) in patients with CIS...
December 2016: Journal of Neurology
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