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mcdonald MS

Fang Zhang, Guiyou Liu, Changjuan Wei, Chao Gao, Junwei Hao
In this study, we strove to substantiate the ability of linc-MAF-4 to act as a regulator of pathogenesis during multiple sclerosis (MS). We recruited 34 patients who were diagnosed with MS according to the revised McDonald Criteria. Six patients with MS and 5 healthy volunteers contributed peripheral blood mononuclear cells for microarray analysis. Subsequent knockdown and overexpression of linc-MAF-4 in naive CD4(+) T cells from the additional 28 patients with MS was performed to track changes in CD4(+) T-cell subsets and their function as well as to confirm results from the prior microarray analysis...
October 18, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Manor Askenazi, Hisham Ben Hamidane, Johannes Graumann
The evolution of data exchange in Mass Spectrometry spans decades and has ranged from human-readable text files representing individual scans or collections thereof (McDonald et al., 2004) through the official standard XML-based (Harold, Means, & Udemadu, 2005) data interchange standard (Deutsch, 2012), to increasingly compressed (Teleman et al., 2014) variants of this standard sometimes requiring purely binary adjunct files (Römpp et al., 2011). While the desire to maintain even partial human readability is understandable, the inherent mismatch between XML's textual and irregular format relative to the numeric and highly regular nature of actual spectral data, along with the explosive growth in dataset scales and the resulting need for efficient (binary and indexed) access has led to a phenomenon referred to as "technical drift" (Davis, 2013)...
October 14, 2016: Mass Spectrometry Reviews
André M Huss, Steffen Halbgebauer, Patrick Öckl, Corinna Trebst, Annette Spreer, Nadja Borisow, Andrea Harrer, Isabel Brecht, Bettina Balint, Oliver Stich, Sabine Schlegel, Nele Retzlaff, Alexander Winkelmann, Romy Roesler, Florian Lauda, Özlem Yildiz, Elke Voß, Rainer Muche, Sebastian Rauer, Florian Then Bergh, Markus Otto, Friedemann Paul, Brigitte Wildemann, Jörg Kraus, Klemens Ruprecht, Martin Stangel, Mathias Buttmann, Uwe K Zettl, Hayrettin Tumani
The majority of patients presenting with a first clinical symptom suggestive of multiple sclerosis (MS) do not fulfill the MRI criteria for dissemination in space and time according to the 2010 revision of the McDonald diagnostic criteria for MS and are thus classified as clinically isolated syndrome (CIS). To re-evaluate the utility of cerebrospinal fluid (CSF) analysis in the context of the revised McDonald criteria from 2010, we conducted a retrospective multicenter study aimed at determining the prevalence and predictive value of oligoclonal IgG bands (OCBs) in patients with CIS...
October 11, 2016: Journal of Neurology
Hamit Yasar Ellidag, Necat Yilmaz, Fatma Kurtulus, Ozgur Aydin, Esin Eren, Ayca Inci, Suleyman Dolu, Fatma Demet Arslan Ince, Özlem Giray, Aylin Yaman
BACKGROUND: The klotho (Klt)-fibroblast growth factor-23 (FGF-23)-vitamin D axis is the main component of calcium (Ca) and phosphorus (P) metabolisms; on the contrary, it is also secreted from the choroid plexus (CP). PURPOSE: This study is aimed at evaluating serum soluble Klt (sKlt), FGF-23, and 25-(OH)-vitamin D levels in multiple sclerosis (MS) patients. METHODS: Thirty-two relapsing-remitting MS patients (11 males and 21 females; mean age 38...
September 2016: Annals of Neurosciences
K S Hardman, P J Everitt, G D McDonald, P Manju, P B Wigley, M A Sooriyabandara, C C N Kuhn, J E Debs, J D Close, N P Robins
A Bose-Einstein condensate is used as an atomic source for a high precision sensor. A 5×10^{6}  atom F=1 spinor condensate of ^{87}Rb is released into free fall for up to 750 ms and probed with a T=130  ms Mach-Zehnder atom interferometer based on Bragg transitions. The Bragg interferometer simultaneously addresses the three magnetic states |m_{f}=1,0,-1⟩, facilitating a simultaneous measurement of the acceleration due to gravity with a 1000 run precision of Δg/g=1.45×10^{-9} and the magnetic field gradient to a precision of 120  pT/m...
September 23, 2016: Physical Review Letters
Wallace J Brownlee, Katherine A Miszkiel, Daniel R Altmann, Olga Ciccarelli, David H Miller
In patients who present with a clinically isolated syndrome (CIS), whose features are suggestive of multiple sclerosis (MS), fulfilling McDonald 2010 magnetic resonance imaging (MRI) criteria for dissemination in space (DIS) and dissemination in time (DIT) enables a diagnosis of MS. While ⩾1 periventricular lesion is included in the 2010 DIS criteria, earlier McDonald criteria required ⩾3 periventricular lesions to confirm DIS and recent Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS)-recommended DIS criteria also require ⩾3 lesions...
September 6, 2016: Multiple Sclerosis: Clinical and Laboratory Research
Marc Tardieu, Brenda Banwell, Jerry S Wolinsky, Daniela Pohl, Lauren B Krupp
In light of the published 2012 International Pediatric Multiple Sclerosis Group definitions for pediatric multiple sclerosis (MS) and related disorders and given that pediatric-onset MS is now formally included in the 2010 McDonald criteria for MS, we sought to review these criteria and summarize their application in children with acquired CNS demyelination. In addition, proposals are made for definitions of no evidence of disease activity and inadequate treatment response that are important because of new therapeutic options and trials...
August 30, 2016: Neurology
Rogier Q Hintzen, Russell C Dale, Rinze F Neuteboom, Soe Mar, Brenda Banwell
Approximately one-third of children with an acquired demyelinating syndrome (ADS) will be diagnosed with multiple sclerosis (MS), either at onset according to the 2010 McDonald criteria, or on the basis of clinical or MRI evidence of relapsing disease, in the majority of patients within 2-4 years. ADS in adolescents, female patients, and patients with polyfocal deficits is associated with the highest likelihood of MS, while children with acute disseminated encephalomyelitis, those with documented preceding infection, and ADS presentation in young children more commonly portends a monophasic outcome...
August 30, 2016: Neurology
Mar Tintore, Susana Otero-Romero, Jordi Río, Georgina Arrambide, Berta Pujal, Carmen Tur, Ingrid Galán, Manuel Comabella, Carlos Nos, María Jesús Arévalo, Angela Vidal-Jordana, Joaquin Castilló, Breogán Rodríguez-Acevedo, Luciana Midaglia, Raquel Mitjana, Cristina Auger, Jaume Sastre-Garriga, Àlex Rovira, Xavier Montalban
OBJECTIVE: To study the contribution of the symptomatic lesion in establishing multiple sclerosis (MS) diagnosis and prognosis. METHODS: We performed an observational study based on a prospective clinically isolated syndrome (CIS) cohort of 1,107 patients recruited for clinical and brain MRI follow-up from 1995 to 2014. Eligible patients (n = 954) were divided into 4 groups according to baseline MRI: patients with a normal MRI (n = 290); patients with a single asymptomatic lesion (n = 18); patients with a single cord/brainstem symptomatic lesion (n = 35); and patients with more than 1 lesion (n = 611)...
September 27, 2016: Neurology
Christine Lebrun, Mikael Cohen, Beatrice Pignolet, Barbara Seitz-Polski, Florence Bucciarelli, Sylvia Benzaken, Orhun Kantarci, Aksel Siva, Darin Okuda, Daniel Pelletier, David Brassat
BACKGROUND: Radiologically isolated syndrome (RIS) is a sub clinical demyelinating neurological disorder and to date no biomarker that triggers the seminal event has been identified. As for multiple sclerosis (MS), disease activity and clinical course are unpredictable. In MS, exploratory studies reported increased IL-17 levels in CSF but results in detecting IL-17 in serum at different stage of the disease are controversial. OBJECTIVES: We investigate levels of IL-17 in serum and CSF in patients diagnosed at different stages of demyelinating diseases (RIS, CIS, relapsing remitting (RR) or active multiple sclerosis patients:AMS) as a marker of inflammatory condition...
September 15, 2016: Journal of the Neurological Sciences
Jamie L Wenke, W Hayes McDonald, Kevin L Schey
PURPOSE: To quantify protein changes in the morphologically distinct remodeling zone (RZ) and adjacent regions of the human lens outer cortex using spatially directed quantitative proteomics. METHODS: Lightly fixed human lens sections were deparaffinized and membranes labeled with fluorescent wheat germ agglutinin (WGA-TRITC). Morphology directed laser capture microdissection (LCM) was used to isolate tissue from four distinct regions of human lens outer cortex: differentiating zone (DF), RZ, transition zone (TZ), and inner cortex (IC)...
August 1, 2016: Investigative Ophthalmology & Visual Science
Georgina Arrambide, Carmen Espejo, Herena Eixarch, Luisa M Villar, José C Alvarez-Cermeño, Carmen Picón, Jens Kuhle, Giulio Disanto, Ludwig Kappos, Jaume Sastre-Garriga, Deborah Pareto, Eva Simon, Manuel Comabella, Jordi Río, Carlos Nos, Carmen Tur, Joaquín Castilló, Angela Vidal-Jordana, Ingrid Galán, Maria J Arévalo, Cristina Auger, Alex Rovira, Xavier Montalban, Mar Tintore
OBJECTIVE: To determine the prognostic value of selected biomarkers in clinically isolated syndromes (CIS) for conversion to multiple sclerosis (MS) and disability accrual. METHODS: Data were acquired from 2 CIS cohorts. The screening phase evaluated patients developing clinically definite MS (CIS-CDMS) and patients who remained as CIS during a 2-year minimum follow-up (CIS-CIS). We determined levels of neurofascin, semaphorin 3A, fetuin A, glial fibrillary acidic protein, and neurofilament light (NfL) and heavy chains in CSF (estimated mean [95% confidence interval; CI])...
September 13, 2016: Neurology
Waldemar Brola, Piotr Sobolewski, Stanisław Flaga, Małgorzata Fudala, Wiktor Szczuchniak, Jan Stoiński, Anita Rosołowska, Jacek Wójcik, Katarzyna Kapica-Topczewska, Danuta Ryglewicz
BACKGROUND: Comprehensive epidemiologic data for multiple sclerosis (MS) in Poland are limited. The aim of this cross-sectional population-based study was to determine the incidence and prevalence of MS in the Swietokrzyskie Region (central Poland). METHODS: This study identified MS cases every year between 1 January 2010 and 31 December 2014. The study area population on the prevalence day (December 31, 2014) was 1,263,176 (646,506 women and 616,670 men). A total of 1462 patients with a clinically definite diagnosis of MS according to McDonald's criteria (2005), recorded in the Polish Multiple Sclerosis Registry, were considered for estimation of crude, age- and sex-specific prevalence, and incidence...
2016: BMC Neurology
Agnieszka Morel, Elzbieta Miller, Michal Bijak, Joanna Saluk
Platelet activation is increasingly postulated as a possible component of the pathogenesis of multiple sclerosis (MS), especially due to the increased risk of cardiovascular events in MS. Arachidonic acid cascade metabolized by cyclooxygenase (COX) is a key pathway of platelet activation. The aim of our study was to investigate the COX-dependent arachidonic acid metabolic pathway in blood platelets from secondary progressive multiple sclerosis (SP MS) patients. The blood samples were obtained from 50 patients (man n = 22; female n = 28), suffering from SP MS, diagnosed according to the revised McDonald criteria...
September 2016: Molecular and Cellular Biochemistry
Ece Balkuv, Asuman Orhan Varoglu, Nihal Isik, Banu Isbilen, Saadettin Duruyen, Recep Basaran, Abdulkadir Kocer
BACKGROUND: Various molecules of the coagulation cascade are thought to have varying roles in the pathophysiology of multiple sclerosis (MS). We aimed to find new information about the effects of the coagulation cascade molecules to develop new therapeutic strategies for MS. MATERIALS AND METHODS: Patients with MS were chosen from among patients who were followed up at our hospital. We examined the thrombomodulin (TM) and activated protein C (APC) serum levels in patients with MS and the healthy controls...
July 2016: Multiple Sclerosis and related Disorders
Wallace J Brownlee, Josephine K Swanton, Katherine A Miszkiel, David H Miller, Olga Ciccarelli
OBJECTIVES: To investigate whether inclusion of lesions in the symptomatic region influences the performance of dissemination in space (DIS) criteria for a diagnosis of clinically definite multiple sclerosis (CDMS) in patients with a clinically isolated syndrome (CIS). METHODS: We studied 30 patients with CIS with brainstem/cerebellar and spinal cord syndromes who had MRI scans at the time of CIS and were followed up for the development of CDMS. We retrospectively applied the McDonald 2010 DIS criteria (excluding all lesions in the symptomatic region) to baseline MRI scans and 2 modified DIS criteria: (1) the inclusion of asymptomatic lesions in the symptomatic region in DIS, and (2) the inclusion of any lesion in the symptomatic region in DIS...
August 16, 2016: Neurology
Yongbo Zhang, Guoyi Liu, Xinwen Han, Huihua Dong, Jia Geng
OBJECTIVE: Low vitamin D levels had been shown to play a role in the pathogenesis of multiple sclerosis (MS). Currently, there is little information regarding the correlation between levels of vitamin D and MS in Chinese. This study aimed at detection of association between serum 25-hydroxyvitamin D [25(OH) D] concentrations and MS and its relation to the disease severity in Chinese. METHODS: The present study was a case-control type, it included 141 patients with definitive MS on the basis of 'McDonald' criteria and 282 age-sex matched controls...
August 15, 2016: Journal of Neuroimmunology
Begoña M Escribano, Macarena Aguilar, Carmen Bahamonde, Cristina Conde, Rafael Lillo, Fernando Sánchez-López, Ana I Giraldo, Antonio H Cruz, Evelio Luque, Félix Gascón, Eduardo Agüera, Isaac Tunez
AIMS: The main aim of this study was to verify the effect of natalizumab on the levels of circulating catecholamines and indolamine and their possible relation with MS. METHODS: For this purpose, 12 healthy individuals (control group) and 12 relapsing-remitting multiple sclerosis patients (RR-MS) were selected. The patients were treated with 300 mg of natalizumab during 56 weeks (1 dose/4 weeks) (MS-56). This selection was based on the McDonalds revision criterion and scheduled to star treatment with natalizumab...
July 7, 2016: Current Pharmaceutical Design
Agnieszka Biedroń, Izabela Witek, Ewa Wesołowska
BACKGROUND: Multiple sclerosis (MS) is a chronic disorder characterized by presence of demyelinating changes in the central nervous system. The disease most often affects young adults with a female predominance, but the first symptoms can also occur in children. MS symptoms in childhood are characterized by a higher incidence of sensory, cerebellar and brainstem disorders compared to adults. They are frequently multifocal especially in the youngest age groups, requiring differentiation of acute disseminated encephalomyelitis...
2016: Przegla̧d Lekarski
Ozlem Goker-Alpan, Nicola Longo, Marie McDonald, Suma P Shankar, Raphael Schiffmann, Peter Chang, Yinghua Shen, Arian Pano
BACKGROUND: Following a drug manufacturing process change, safety/efficacy of agalsidase alfa were evaluated in enzyme replacement therapy (ERT)-naïve children with Fabry disease. METHODS: In an open-label, multicenter, Phase II study (HGT-REP-084; Shire), 14 children aged ≥7 years received 0.2 mg/kg agalsidase alfa every other week for 55 weeks. Primary endpoints: safety, changes in autonomic function (2-hour Holter monitoring). Secondary endpoints: estimated glomerular filtration rate, left ventricular mass index (LVMI), midwall fractional shortening, pharmacodynamic parameters, and patient-reported quality-of-life...
2016: Drug Design, Development and Therapy
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