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https://www.readbyqxmd.com/read/29165865/mimicking-class-ib-mn2-ribonucleotide-reductase-a-mnii2-complex-and-its-reaction-with-superoxide
#1
Adriana Magherusan, Ang Zhou, Erik Farquhar, Max Garcia Melchor, Brendan Twamley, Lawrence Que, Aidan Richard McDonald
Class Ib RNRs require superoxide anion (O2*-), rather than dioxygen (O2), to access a high-valent Mn2 oxidant. Complex 1 ([Mn2(O2CCH3)(N-Et-HPTB)](ClO4)2, N-Et-HPTB = N,N,N',N'-tetrakis(2-(1-ethylbenzimidazolyl))-2-hydroxy-1,3-diaminopropane) was synthesised in high yield (90%). 1 was reacted with O2*- at -40 °C resulting in the formation of a metastable species (2). 2 displayed electronic absorption features (λmax = 460, 610 nm) typical of a Mn-peroxide species, and a 29 line EPR signal typical of a MnIIMnIII entity...
November 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29136613/increasing-incidence-and-prevalence-of-multiple-sclerosis-in-puerto-rico-2013-2016
#2
Angel Chinea, Carlos F Ríos-Bedoya, Ivonne Vicente, Cristina Rubí, Guillermo García, Ana Rivera, Astrid Díaz, Eduardo Estades Romero, Yatzka Hernández Silvestrini, Yaritza Díaz
BACKGROUND: The incidence of multiple sclerosis (MS) has been increasing worldwide over the past decades. However, this upward trend has not been examined at the country level in Latin America and the Caribbean (LAC). The aims of this study are to examine trends of MS incidence over 4 years and to provide age- and gender-standardized incidence rate estimates for a Caribbean island. METHODS: Data from the Puerto Rico (PR) MS Foundation's registry was used to identify all newly diagnosed MS cases between 2013 and 2016...
November 14, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29121465/co-culture-of-marine-invertebrate-associated-bacteria-and-interdisciplinary-technologies-enable-biosynthesis-and-discovery-of-a-new-antibiotic-keyicin
#3
Navid Adnani, Marc Chevrette, Srikar N Adibhatla, Fan Zhang, Qing Yu, Doug R Braun, Justin Nelson, Scott W Simpkins, Bradon R McDonald, Chad L Myers, Jeff S Piotrowski, Christopher J Thompson, Cameron R Currie, Lingjun Li, Scott R Rajski, Tim S Bugni
Advances in genomics and metabolomics have made clear in recent years that microbial biosynthetic capacities on Earth far exceed previous expectations. This is attributable, in part, to the realization that most microbial natural product (NP) producers harbor biosynthetic machineries not readily amenable to classical laboratory fermentation conditions. Such "cryptic" or dormant biosynthetic gene clusters (BGCs) encode for a vast assortment of potentially new antibiotics and, as such, have become extremely attractive targets for activation under controlled laboratory conditions...
November 9, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29115354/human-anthocyanin-bioavailability-effect-of-intake-duration-and-dosing
#4
Wilhelmina Kalt, Jane E McDonald, Melinda R Vinqvist-Tymchuk, Yan Liu, Sherry A E Fillmore
While in vitro and animal evidence supports a role for anthocyanins in human health, future opportunities in berry health benefits will rest upon evidence from clinical intervention trials. Because little is known about the behaviour of anthocyanins during long term intake in humans, several clinical design factors were examined. Urine from volunteers (n = 17) who consumed blueberry juice daily was analysed using LC-MS/MS for predicted flavonoid-based products of anthocyanins in relation to a 5-day anthocyanin-free run-in, 28 days of blueberry juice intake, a 7-day washout and two dosing regimens...
November 8, 2017: Food & Function
https://www.readbyqxmd.com/read/29104793/increased-risk-of-erectile-dysfunction-in-men-with-multiple-sclerosis-an-italian-cross-sectional-study
#5
Raffaele Balsamo, Davide Arcaniolo, Marco Stizzo, Ester Illiano, Riccardo Autorino, Franca Natale, Elisabetta Costantini, Rocco Damiano, Marco De Sio
Introduction: Sexual dysfunctions (SDs) are common, but often underestimated symptoms in men with multiple sclerosis (MS). The most common sexual complaint in a multiple sclerosis male is erectile dysfunction (ED). The aim of this observational, cross-sectional study was to assess the prevalence of erectile dysfunction (ED) and its relationship with neurological disability, depression, urodynamic findings and lower urinary tract symptoms (LUTS) in these patients. Material and methods: From January 2014 to January 2016, there were 101 consecutive male patients with a diagnosis of Multiple Sclerosis according to the McDonald revised criteria and stable sexual relationships were included...
2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/29082586/use-and-misuse-of-the-mcdonald-criteria-to-diagnose-multiple-sclerosis
#6
Wallace J Brownlee
The McDonald criteria allow the use of MRI to provide evidence of dissemination in space and time to establish a diagnosis of multiple sclerosis (MS), including in people with a single clinical event, or clinically isolated syndrome (CIS) [1]. The original criteria published in 2001 were revised based on evidence from large, multicentre European studies [2]. The high sensitivity and specificity of the McDonald criteria for the development of clinically-definite MS (CDMS) has been confirmed in number of studies...
October 30, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29051829/the-efficacy-of-cladribine-tablets-in-cis-patients-retrospectively-assigned-the-diagnosis-of-ms-using-modern-criteria-results-from-the-oracle-ms-study
#7
Mark S Freedman, Thomas P Leist, Giancarlo Comi, Bruce Ac Cree, Patricia K Coyle, Hans-Peter Hartung, Patrick Vermersch, Doris Damian, Fernando Dangond
BACKGROUND: Multiple sclerosis (MS) diagnostic criteria have changed since the ORACLE-MS study was conducted; 223 of 616 patients (36.2%) would have met the diagnosis of MS vs clinically isolated syndrome (CIS) using the newer criteria. OBJECTIVE: The objective of this paper is to assess the effect of cladribine tablets in patients with a first clinical demyelinating attack fulfilling newer criteria (McDonald 2010) for MS vs CIS. METHODS: A post hoc analysis for subgroups of patients retrospectively classified as fulfilling or not fulfilling newer criteria at the first clinical demyelinating attack was conducted...
October 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/29034645/peripheral-neuropathy-in-multiple-sclerosis-an-electrophysiologic-study-in-iranian-patients
#8
Mohammad Reza Emad, Leila Zeinali, Alireza Nikseresht, Mahshid Naseri, Hajar Karimian
Multiple sclerosis (MS) is the most common cause of disability after trauma in young adults in Northern Hemisphere; it imposes a major burden on the affected young people. A significant association between MS and demyelinating peripheral neuropathy which might be due to common pathogenesis for the central and peripheral nerves demyelination has been reported in several studies. We aimed to assess if there is any peripheral nervous system involvement in a sample of Iranian MS population. Extensive nerve conduction studies (NCS) were conducted in 20 MS patients according to McDonald criteria, and 20 age and gender matched healthy appearing controls...
August 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29024243/low-clinical-conversion-rate-in-clinically-isolated-syndrome-cis-patients-diagnostic-benefit-of-mcdonald-2010-criteria
#9
Sina Cathérine Rosenkranz, Barbara Kaulen, Anneke Neuhaus, Susanne Siemonsen, Sascha Köpke, Martin Daumer, Jan-Patrick Stellmann, Christoph Heesen
BACKGROUND: New diagnostic criteria of Multiple Sclerosis (MS) increase the number of patients being diagnosed with MS while a substantial part might not convert to clinically definite MS (CDMS). OBJECTIVE: Diagnostic accuracy of the McDonald 2005 and 2010 criteria for conversion to CDMS was evaluated in an unselected cohort of patients in whom a MS diagnostic workup was decided. METHODS: We analyzed clinical, MRI and CSF data in all patients who presented with symptoms suspicious for MS at the University based MS outpatient clinic between 2006 and 2010 (n=165)...
October 11, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29023976/peripheral-nerve-involvement-in-multiple-sclerosis-demonstration-by-magnetic-resonance-neurography
#10
Johann M E Jende, Gesa H Hauck, Ricarda Diem, Markus Weiler, Sabine Heiland, Brigitte Wildemann, Mirjam Korporal-Kuhnke, Wolfgang Wick, John M Hayes, Johannes Pfaff, Mirko Pham, Martin Bendszus, Jennifer Kollmer
OBJECTIVE: To detect and quantify peripheral nerve lesions in multiple sclerosis (MS) by magnetic resonance neurography (MRN). METHODS: Thirty-six patients diagnosed with MS based on the 2010 McDonald criteria (34 with the relapsing-remitting form, 2 with clinically isolated syndrome) with and without disease-modifying treatment were compared to 35 healthy age-/sex-matched volunteers. All patients underwent detailed neurological and electrophysiological examinations...
October 10, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28991707/tumefactive-demyelinating-lesions-of-15-patients-clinico-radiological-features-management-and-review-of-the-literature
#11
Pedro Sánchez, Virginia Meca-Lallana, Antonio Barbosa, Rafael Manzanares, Itziar Palmí, José Vivancos
BACKGROUND AND OBJECTIVE: Tumefactive demyelinating lesions (TDLs) are large inflammatory lesions that can mimic tumors or other space-occupying lesions. Differential diagnosis and management of these lesions remain challenging for neurologists. We aim to review the clinico-radiological features of patients with TDLs, as well as their management. METHODS: We performed a retrospective review of cases of TDLs treated in our center from January 2010 to February 2017...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28979793/application-of-the-mcdonald-criteria-in-latin-america
#12
REVIEW
Liliana Patrucco
The diagnosis of multiple sclerosis (MS) is based on neurological symptoms and signs, alongside evidence of dissemination of central nervous system (CNS) lesions in space and time. In the absence of a sensitive and specific diagnostic test, diagnostic criteria are needed for diagnosing MS. The caveat to the application of the McDonald criteria is that alternative diagnoses must be excluded. The prevalence, clinical phenotype and the differential diagnosis of MS may have variations in different populations, especially in Latin America (LATAM)...
July 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28959664/neuropharmacological-profile-and-chemical-analysis-of-fresh-rhizome-essential-oil-of-curcuma-longa-turmeric-cultivated-in-southwest-nigeria
#13
Idris A Oyemitan, Christianah A Elusiyan, Ayoola O Onifade, Moses A Akanmu, Adebola O Oyedeji, Armando G McDonald
BACKGROUND: Curcuma longa (turmeric) is commonly used as spice and also used to treat fever, cough and febrile convulsions in Nigeria. This study determined the chemical composition of the essential oil of C. longa and evaluated its neuropharmacological activity in mice. METHODS: Essential oil of C. longa (EOCL) fresh rhizome was obtained by hydrodistillation and its chemical composition determined by GC-MS. Acute toxicity (LD50) profile of the essential oil was determined orally (p...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28953254/clinically-isolated-syndrome-according-to-mcdonald-2010-intrathecal-igg-synthesis-still-predictive-for-conversion-to-multiple-sclerosis
#14
Philipp Schwenkenbecher, Anastasia Sarikidi, Lena Bönig, Ulrich Wurster, Paul Bronzlik, Kurt-Wolfram Sühs, Refik Pul, Martin Stangel, Thomas Skripuletz
While the revised McDonald criteria of 2010 allow for the diagnosis of multiple sclerosis (MS) in an earlier stage, there is still a need to identify the risk factors for conversion to MS in patients with clinically isolated syndrome (CIS). Since the latest McDonald criteria were established, the prognostic role of cerebrospinal fluid (CSF) and visual evoked potentials (VEP) in CIS patients is still poorly defined. We conducted a monocentric investigation including patients with CIS in the time from 2010 to 2015...
September 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28932368/cancer-risk-among-patients-with-multiple-sclerosis-a-cohort-study-in-isfahan-iran
#15
Masoud Etemadifar, Hamidreza Jahanbani-Ardakani, Sara Ghaffari, Maboobeh Fereidan-Esfahani, Hossein Changaei, Nazila Aghadoost, Ameneh Jahanbani Ardakani, Negin Moradkhani
BACKGROUND: Multiple sclerosis (MS), a central nervous system (CNS) autoimmune disorder, affects 2.3 million people around the world. Cancer kills around 7.5 million people annually. Both diseases have similar risks and intertwining molecular causes. Most studies focusing on MS and cancer have found an insignificant difference or reduction in the amount of cancer found in the MS community. METHODS: We performed a cohort study using data from Isfahan Multiple Sclerosis Society (IMSS) and Isfahan cancer society and followed-up for 8 years on average (2006-2014)...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28917753/nuclear-forensics-investigation-of-morphological-signatures-in-the-thermal-decomposition-of-uranyl-peroxide
#16
Ian J Schwerdt, Adam Olsen, Robert Lusk, Sean Heffernan, Michael Klosterman, Bryce Collins, Sean Martinson, Trenton Kirkham, Luther W McDonald
The analytical techniques typically utilized in a nuclear forensic investigation often provide limited information regarding the process history and production conditions of interdicted nuclear material. In this study, scanning electron microscopy (SEM) analysis of the surface morphology of amorphous-UO3 samples calcined at 250, 300, 350, 400, and 450°C from uranyl peroxide was performed to determine if the morphology was indicative of the synthesis route and thermal history for the samples. Thermogravimetic analysis-mass spectrometry (TGA-MS) and differential scanning calorimetry (DSC) were used to correlate transitions in the calcined material to morphological transformations...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28885372/light-therapy-for-multiple-sclerosis-associated-fatigue-study-protocol-for-a-randomized-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Farrah J Mateen, Natalie C Manalo, Sara J Grundy, Melissa A Houghton, Gladia C Hotan, Hans Erickson, Aleksandar Videnovic
BACKGROUND: Fatigue is the most commonly reported symptom among multiple sclerosis (MS) patients, more than a quarter of whom consider fatigue to be their most disabling symptom. However, there are few effective treatment options for fatigue. We aim to investigate whether supplemental exposure to bright white light will reduce MS-associated fatigue. METHODS: Eligible participants will have clinically confirmed multiple sclerosis based on the revised McDonald criteria (2010) and a score ≥36 on the Fatigue Severity Scale (FSS)...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28744195/machine-learning-approach-for-classifying-multiple-sclerosis-courses-by-combining-clinical-data-with-lesion-loads-and-magnetic-resonance-metabolic-features
#18
Adrian Ion-Mărgineanu, Gabriel Kocevar, Claudio Stamile, Diana M Sima, Françoise Durand-Dubief, Sabine Van Huffel, Dominique Sappey-Marinier
Purpose: The purpose of this study is classifying multiple sclerosis (MS) patients in the four clinical forms as defined by the McDonald criteria using machine learning algorithms trained on clinical data combined with lesion loads and magnetic resonance metabolic features. Materials and Methods: Eighty-seven MS patients [12 Clinically Isolated Syndrome (CIS), 30 Relapse Remitting (RR), 17 Primary Progressive (PP), and 28 Secondary Progressive (SP)] and 18 healthy controls were included in this study. Longitudinal data available for each MS patient included clinical (e...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28734607/impact-of-instrument-and-column-parameters-on-high-throughput-liquid-chromatography-performance
#19
Martin Gilar, Thomas S McDonald, Fabrice Gritti
The speed and separation performance of high-throughput liquid chromatography (HT LC) was investigated. We evaluated the contributions of various experimental parameters to the total analysis cycle time, including column length (column void time), gradient delay, flow rate, auto-sampler (A/S) speed, and software related delays. The best case injection-to-injection cycle time of 22s was achieved using 12s gradient time and 2.1×20mm columns packed with 1.7μm C18 particles. The total 22s analytical duty cycle consisted of 2...
July 11, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28716249/high-risk-of-early-conversion-to-multiple-sclerosis-in-clinically-isolated-syndromes-with-dissemination-in-space-at-baseline
#20
Lorenzo Gaetani, Fulvia Fanelli, Ilenia Riccucci, Paolo Eusebi, Paola Sarchielli, Carlo Pozzilli, Paolo Calabresi, Luca Prosperini, Massimiliano Di Filippo
INTRODUCTION: Multiple sclerosis (MS) usually presents at onset with a clinically isolated syndrome (CIS). According to 2010 McDonald criteria, a diagnosis of MS can be made if CIS patients satisfy clinical/MRI criteria of both dissemination in time (DIT) and space (DIS). OBJECTIVE: The aim of this study was to analyze the follow-up data and possible prognostic factors of CIS patients satisfying DIS MRI criteria. PATIENTS AND METHODS: We performed a retrospective, multicenter study across 2 Italian centers...
August 15, 2017: Journal of the Neurological Sciences
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