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https://www.readbyqxmd.com/read/27878417/neurobehavioural-evaluation-of-resveratrol-in-murine-models-of-anxiety-and-schizophrenia
#1
Mohammed Garba Magaji, Loretta Oghenekome Iniaghe, Mutiat Abolarin, Opeyemi Isa Abdullahi, Rabiu Abdusalam Magaji
Resveratrol, a caloric restriction mimetic, is a naturally occurring polyphenolic compound with antioxidant and anti-inflammatory properties. Oxidative stress has been implicated in the etiology of a number of neuropsychiatric disorders including generalized anxiety and schizophrenia. This study investigated the anxiolytic and antipsychotic potentials of resveratrol in murine models of anxiety and schizophrenia. Mice were pretreated with resveratrol (200 and 400 mg/kg) in 1% carboxymethyl cellulose for 14 days and subjected to behavioural tests on the 15th day...
November 22, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27872683/safe-and-effective-sofosbuvir-based-therapy-in-patients-with-mental-health-disease-on-hepatitis-c-virus-treatment
#2
Lydia Shuk Yee Tang, Jack Masur, Zayani Sims, Amy Nelson, Anu Osinusi, Anita Kohli, Sarah Kattakuzhy, Michael Polis, Shyam Kottilil
AIM: To study impact of baseline mental health disease on hepatitis C virus (HCV) treatment; and Beck's Depression Inventory (BDI) changes with sofosbuvir- and interferon-based therapy. METHODS: This is a retrospective cohort study of participants from 5 studies enrolled from single center trials conducted at the Clinical Research Center of the National Institutes of Health, Bethesda, MD, United States. All participants were adults with chronic HCV genotype 1 infection and naïve to HCV therapy...
November 8, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27866493/dietary-dha-and-health-cognitive-function-ageing
#3
Carlos Cardoso, Cláudia Afonso, Narcisa M Bandarra
DHA is a key nutritional n-3 PUFA and needs to be supplied by the human diet. DHA is found in significant amounts in the retinal and neuronal cell membranes due to its high fluidity. Indeed, DHA is selectively concentrated in the synaptic and retinal membranes. DHA is deemed to display anti-inflammatory properties and to reduce the risk of CVD. Consumption of larger amounts of DHA appears to reduce the risk of depression, bipolar disorder, schizophrenia and mood disorders. Conversely, it has been shown that loss of DHA from the nerve cell membrane leads to dysfunction of the central nervous system in the form of anxiety, irritability, susceptibility to stress, dyslexia, impaired memory and cognitive functions, and extended reaction times...
November 21, 2016: Nutrition Research Reviews
https://www.readbyqxmd.com/read/27863524/positive-mental-health-in-outpatients-comparison-within-diagnostic-groups
#4
Rajeswari Sambasivam, Janhavi Ajit Vaingankar, Siow Ann Chong, Edimansyah Abdin, Anitha Jeyagurunathan, Lee Seng Esmond Seow, Shirlene Pang, Mythily Subramaniam
BACKGROUND: Positive mental health (PMH) supplements the definition of mental health which is not just the mere absence of mental illness. It encompasses an individual's social, emotional and psychological well-being. This cross-sectional study examines the PMH levels in a multi-ethnic outpatient population and the socio-demographic correlates of PMH across the various diagnostic groups. In addition comparisons with the general population were conducted. METHODS: Outpatients with schizophrenia spectrum, depressive or anxiety disorders seeking treatment at a tertiary psychiatric care hospital were included in the study sample...
November 18, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27837574/there-is-no-safe-threshold-for-lead-exposure-%C3%AE-literature-review
#5
Th Vorvolakos, S Arseniou, M Samakouri
: Lead was one of the most dangerous environmental toxic substances for a long time in western countries, and this is still the case for many places on earth today. Its neurotoxic potential is highly significant but its secure blood level concentration remains unknown. The aim of this study was to approach the above issue from the perspective of social psychiatry. A systematic search was made of Dialog and Datastar interfaces for data regarding the neuropsychiatric complications of direct or chronic exposure to lead, and a review of the relevant literature was conducted using the databases Medline, Embase, CAB Global Health and Cochrane...
July 2016: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/27837572/clinical-and-cognitive-factors-affecting-psychosocial-functioning-in-remitted-patients-with-bipolar-disorder
#6
G Konstantakopoulos, N Ioannidi, M Typaldou, D Sakkas, P Oulis
Impaired interpersonal, social, and occupational functioning is very often observed in patients with bipolar disorder, not only at the acute stages of the illness but in remission as well. This finding raises the question of multiple factors that might affect psychosocial functioning in bipolar patients, such as residual subsyndromal symptoms and neuropsychological deficits. Social cognition impairment, especially impaired Theory of Mind (ToM), might also play an important role in bipolar patients' every-day functioning, similarly to what was found in patients with schizophrenia...
July 2016: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/27831757/developing-a-virtual-reality-based-vocational-rehabilitation-training-program-for-patients-with-schizophrenia
#7
Bo Kyung Sohn, Jae Yeon Hwang, Su Mi Park, Jung-Seok Choi, Jun-Young Lee, Ji Yeuon Lee, Hee-Yeon Jung
Maintaining employment is difficult for patients with schizophrenia because of deterioration of psychosocial and cognitive functions. Such patients usually require vocational rehabilitation training, which is both demanding and costly. In this study, we developed a virtual reality-based vocational rehabilitation training program (VR-VRTP) for such patients and evaluated its feasibility as an alternative to traditional rehabilitation programs. We developed the VR-VRTP to include various situations commonly encountered in two types of occupations: convenience store employee and supermarket clerk...
November 2016: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/27827293/vitamin-d-deficiency-behavioral-atypicality-anxiety-and-depression-in-children-with-chromosome-22q11-2-deletion-syndrome
#8
L Kelley, A F P Sanders, E A Beaton
Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a complex developmental disorder with serious medical, cognitive and emotional symptoms across the lifespan. This genetic deletion also imparts a lifetime risk for developing schizophrenia that is 25-30 times that of the general population. The origin of this risk is multifactorial and may include dysregulation of the stress response and immunological systems in relation to brain development. Vitamin D is involved in brain development and neuroprotection, gene transcription, immunological regulation and influences neuronal signal transduction...
December 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27821363/the-use-of-the-sdq-with-chinese-adolescents-in-the-clinical-context
#9
David Mellor, Wenhong Cheng, Marita McCabe, Mathew Ling, Yi Liu, Zhimin Zhao, Juan Fan, Meina You, Fang Zhang, Jinhua Sun, Linda Byrne, Yifeng Xu
This study investigated the psychometric properties of the Strengths and Difficulties Questionnaire when it was applied to a sample of 443 outpatients in China. Included in the sample were 88 adolescents diagnosed with depression, 96 with schizophrenia, 98 with generalized anxiety, 70 with OCD, and 91 with ADHD. Each patient and one of their parents completed the SDQ at intake. Confirmatory Factor Analyses provided limited support for the proposed five factor structure of the scale over other models. Internal reliabilities of the subscales for both self and parent report were weak, and inter-rater agreement between self- and parent-report was moderate...
October 19, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27790574/evaluation-of-xerostomia-in-different-psychological-disorders-an-observational-study
#10
Suresh Kandagal Veerabhadrappa, Pramod Redder Chandrappa, Snehal Patil, Seema Yadav Roodmal, Akshay Kumarswamy, Mounesh Kumar Chappi
INTRODUCTION: Psychiatric diseases like anxiety, depression, schizophrenia and bipolar disorders are increasing at an alarming rate. These diseases can affect the quantity and quality of saliva leading to multiple oral diseases. Although many researchers have evaluated xerostomia in general population, its prevalence is not been assessed in patients suffering from different psychological disorders. AIM: To investigate the prevalence of xerostomia and to assess the correlation between xerostomia and dryness of lip and mucosa in different psychological disorders...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27776604/negative-affect-perceived-health-and-endocrine-and-immunological-levels-in-caregivers-of-offspring-with-schizophrenia
#11
Sara De Andrés-García, Irene Cano-López, Luis Moya-Albiol, Esperanza González-Bono
BACKGROUND: Negative affect (NA) and chronic stress are separately associated with health imbalances, and the interaction between the two aspects remains unclear. Care of relatives with long-term pathologies could be a likely model in the study of this issue, as caregivers frequently report chronic stress and health complaints. The aim of this study is examine the role of NA on psychophysiological stress-induced response and health in schizophrenia caregivers. METHOD: Forty-one caregivers were distributed into two groups accordingly to their scores in NA...
November 2016: Psicothema
https://www.readbyqxmd.com/read/27735056/differential-expression-of-cytoskeletal-regulatory-factors-in-the-adolescent-prefrontal-cortex-implications-for-cortical-development
#12
Lauren P Shapiro, Ryan G Parsons, Anthony J Koleske, Shannon L Gourley
The prevalence of depression, anxiety, schizophrenia, and drug and alcohol use disorders peaks during adolescence. Further, up to 50% of "adult" mental health disorders emerge in adolescence. During adolescence, the prefrontal cortex (PFC) undergoes dramatic structural reorganization, in which dendritic spines and synapses are refined, pruned, and stabilized. Understanding the molecular mechanisms that underlie these processes should help to identify factors that influence the development of psychiatric illness...
October 13, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27732031/attentional-processing-of-emotional-faces-in-schizophrenia-evidence-from-eye-tracking
#13
Seon-Kyeong Jang, Sujin Kim, Chai-Youn Kim, Hyeon-Seung Lee, Kee-Hong Choi
Severe emotional disturbances such as anxiety and depression have been closely related to aberrant attentional processing of emotional stimuli. However, this has been little studied in schizophrenia, which is also characterized by marked emotional impairments such as heightened negative affect and anhedonia. In the current study, we investigated temporal dynamics of motivated attention to emotional stimuli in schizophrenia. For this purpose, we tracked eye movements of 22 individuals with schizophrenia or schizoaffective disorder (ISZs) and 19 healthy controls (HCs) to emotional (i...
October 2016: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/27676446/endocannabinoid-signaling-in-social-functioning-an-rdoc-perspective
#14
D S Karhson, A Y Hardan, K J Parker
Core deficits in social functioning are associated with various neuropsychiatric and neurodevelopmental disorders, yet biomarker identification and the development of effective pharmacological interventions has been limited. Recent data suggest the intriguing possibility that endogenous cannabinoids, a class of lipid neuromodulators generally implicated in the regulation of neurotransmitter release, may contribute to species-typical social functioning. Systematic study of the endogenous cannabinoid signaling could, therefore, yield novel approaches to understand the neurobiological underpinnings of atypical social functioning...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27664549/assessment-of-attachment-in-psychosis-a-psychometric-cause-for-concern
#15
Charles M Olbert, David L Penn, Steven P Reise, William P Horan, Robert S Kern, Junghee Lee, Michael F Green
Attachment has recently been proposed as a key developmental construct in psychosis, in particular with respect to interpersonal functioning and social cognition. The current study examined the latent structure of the self-report Psychosis Attachment Measure (PAM) and its relationship to lower-level perceptual and higher-order inferential social cognitive processes. The PAM was administered to 138 psychiatrically stable outpatients with schizophrenia alongside a battery of symptom, social cognitive, and functional measures...
September 15, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27644915/-schizotypal-personality-questionnaire-brief-likert-format-factor-structure-analysis-in-general-population-in-france
#16
A Ferchiou, L Todorov, M Lajnef, G Baudin, B Pignon, J-R Richard, M Leboyer, A Szöke, F Schürhoff
INTRODUCTION: The main objective of the study was to explore the factorial structure of the French version of the Schizotypal Personality Questionnaire-Brief (SPQ-B) in a Likert format, in a representative sample of the general population. In addition, differences in the dimensional scores of schizotypy according to gender and age were analyzed. As the study in the general population of schizotypal traits and its determinants has been recently proposed as a way toward the understanding of aetiology and pathophysiology of schizophrenia, consistent self-report tools are crucial to measure psychometric schizotypy...
September 16, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27578772/erratum
#17
(no author information available yet)
UNLABELLED: Patten SB, Williams JVA, Lavorato DH, et al. Perceived stigma among recipients of mental health care in the general Canadian population. Can J Psychiatry. 2016;61(8): 480-488. (Original DOI: 10.1177/0706743716639928)The published French translation of the above article's abstract was incorrect. The original English abstract for the above article and the correct French translation are provided below: OBJECTIVES: The Mental Health Experiences Scale is a measure of perceived stigma, the perception of negative attitudes and behaviours by people with mental disorders...
October 2016: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/27565700/validation-of-the-warwick-edinburgh-mental-well-being-scale-wemwbs-in-french-psychiatric-and-general-populations
#18
Marion Trousselard, Dominique Steiler, Frédéric Dutheil, Damien Claverie, Frédéric Canini, Fabien Fenouillet, Geraldine Naughton, Sarah Stewart-Brown, Nicolas Franck
The Warwick-Edinburgh Mental Well-Being Scale (WEMWBS) has been validated in general population samples in many countries. Interest in using this measure in clinical populations is growing, particularly for tertiary prevention and mental health promotion. This paper reports validation of the French WEMWBS in healthy and chronic remitted schizophrenia populations. The French WEMWBS was administered to 319 workers, 75 students and 121 patients. For non-patients, self-reported Trait- and State-Anxiety, Mindfulness, Positive and Negative Affect and the General Health Questionnaire were completed...
November 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27558472/the-mental-health-and-wellbeing-of-first-generation-migrants-a-systematic-narrative-review-of-reviews
#19
REVIEW
Ciara Close, Anne Kouvonen, Tania Bosqui, Kishan Patel, Dermot O'Reilly, Michael Donnelly
BACKGROUND: First generation migrants are reportedly at higher risk of mental ill-health compared to the settled population. This paper systematically reviews and synthesizes all reviews on the mental health of first generation migrants in order to appraise the risk factors for, and explain differences in, the mental health of this population. METHODS: Scientific databases were searched for systematic reviews (inception-November 2015) which provided quantitative data on the mental ill-health of first generation migrants and associated risk factors...
2016: Globalization and Health
https://www.readbyqxmd.com/read/27513883/polycystic-ovary-syndrome-and-psychiatric-disorders-co-morbidity-and-heritability-in-a-nationwide-swedish-cohort
#20
Carolyn E Cesta, Mattias Månsson, Camilla Palm, Paul Lichtenstein, Anastasia N Iliadou, Mikael Landén
Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting 5-15% of reproductive-aged women and characterized by high levels of circulating androgens. Given that androgens have been implicated in the aetiology of several psychiatric disorders, it was hypothesized that women with PCOS have high risk for psychiatric comorbidity. We aimed to investigate this risk amongst women with PCOS, as well as in their siblings, to elucidate if familial factors underlie any potential associations. Using the Swedish national registers, we identified all women diagnosed with PCOS between 1990 and 2013 (n=24,385), their full-siblings (n=25,921), plus matched individuals (1:10/100) from the general population and their full-siblings...
November 2016: Psychoneuroendocrinology
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