Bingdong Sui, Runci Wang, Chider Chen, Xiaoxing Kou, Di Wu, Yu Fu, Fangcao Lei, Yanzhuang Wang, Yijing Liu, Xiaoyuan Chen, Hui Xu, Yingying Liu, Junjun Kang, Haixiang Liu, Ryan Tsz Kin Kwok, Ben Zhong Tang, Hexin Yan, Minjun Wang, Lei Xiang, Xutong Yan, Xiao Zhang, Lan Ma, Songtao Shi, Yan Jin
BACKGROUND & AIMS: Apoptosis generates plenty of membrane-bound nanovesicles, the apoptotic vesicles (apoVs), which show promise for biomedical applications. The liver serves as a significant organ for apoptotic material removal. Whether and how the liver metabolizes apoptotic vesicular products and contributes to liver health and disease are unrecognized. METHODS: ApoVs were labeled and traced after intravenous infusion. Apoptosis-deficient mice by Fas mutant (Fasmut ) and Caspase-3 knockout (Casp3-/- ) were used with apoV replenishment to evaluate the physiological apoV function...
February 9, 2024: Gastroenterology