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Hemotology oncology

Marcio A da Fonseca, Catherine Hong
Hematopoietic stem cell transplant (HSCT) is the treatment of choice for many hematologic, genetic, oncologic, and immunologic diseases. It is also one of the most aggressive treatments among the different cancer therapies, however, and is associated with severe conditioning-related toxicity, profound neutropenia, a high level of prophylactic immunosuppression and graft-vs-host disease (GVHD). Even with GVHD prophylaxis, chronic GVHD remains a significant complication of HSCT and is a frequent reason for nonrelapse morbidity and mortality following allogeneic HSCT...
March 2008: Pediatric Dentistry
Muhammad Jamshaid, Samia Yousuf, Nadeem Irfan Bukhari, Amir Ali Rizvi
Three commercially available brands of amikacin were investigated in a parallel study design for the assessment of comparative pharmacokinetics in pediatric oncology patients with chemotherapy-induced neutropenic febrile episode. Amikacin concentration in serum samples was determined by fluorescence polarization immunoassay method using Abbott TDx system. Computer software, PK II was used for computation of pharmacokinetic parameters of amikacin. The serum concentration of all brands nonsignificantly (p > 0...
January 2003: European Journal of Drug Metabolism and Pharmacokinetics
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