Yuanlin Ma, Kai Gao, Xiaoxuan Sun, Jinxin Wang, Yang Yang, Jianying Wu, Anping Chai, Li Yao, Nan Liu, Hao Yu, Yi Su, Tianlan Lu, Lifang Wang, Weihua Yue, Xiaohui Zhang, Lin Xu, Dai Zhang, Jun Li
Synaptic dysfunction is a core component of the pathophysiology of schizophrenia. However, the genetic risk factors and molecular mechanisms related to synaptic dysfunction are still not fully understood. The Stonin 2 (STON2) gene encodes a major adaptor for clathrin-mediated endocytosis (CME) of synaptic vesicles. In this study, we showed that the C-C (307Pro-851Ala) haplotype of STON2 increases the susceptibility to schizophrenia and examined whether STON2 variations cause schizophrenia-like behaviors through the regulation of CME...
February 13, 2024: Science Bulletin