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https://www.readbyqxmd.com/read/29775777/antidepressant-potential-of-novel-flavonoids-derivatives-from-sweet-violet-viola-odorata-l-pharmacological-biochemical-and-computational-evidences-for-possible-involvement-of-serotonergic-mechanism
#1
Nasiara Karim, Imran Khan, Abeer Abdelhalim, Ajmal Khan, Sobia Ahsan Halim
Plant-derived natural constituents are of great interest in modern drug discovery due to their natural diversity. Viola odorata L has been traditionally used for the treatment of neuropsychiatric disorders. The present study was undertaken to isolate phytoconstituents including three flavonoids 5,7-Dihydroxy-3,6-dimethoxyflavone[1] 5,7,4'-trihydroxy-3',5'dimethoxyflavone [2] and 5,7,4'-trihydroxy-3'-methoxyflavone [3] from the whole plant of Viola odorata L and to investigate the antidepressant-like effects of these compounds and their possible mechanism of action using antagonists of the serotonergic, dopaminergic and adrenergic system...
May 15, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29773358/-antidepressive-agents-and-hyponatremia-a-literature-review-and-a-case-non-case-study-in-the-french-pharmacovigilance-database
#2
Michaël Rochoy, Christina Zakhem-Stachera, Johana Béné, Christophe Berkhout, Sophie Gautier
OBJECTIVE: Most antidepressants have been associated with a risk of hyponatremia in the literature. This effect is not always reported in monographs. The aim of our study was to clarify the difference of increased risk of hyponatremia among various antidepressants. METHODS: Retrospective study of such cases/non-cases from observations recorded in the French national pharmacovigilance between 01/01/2004 and 31/12/2013. We studied all antidepressants marketed in 2014 in France, with a positive control (haloperidol) and a negative one (amoxicillin)...
March 1, 2018: Thérapie
https://www.readbyqxmd.com/read/29767323/prevalence-and-risk-factors-related-to-haloperidol-use-for-delirium-in-adult-intensive-care-patients-the-multinational-aid-icu-inception-cohort-study
#3
Marie O Collet, Jesús Caballero, Romain Sonneville, Fernando A Bozza, Peter Nydahl, Anna Schandl, Hilden Wøien, Giuseppe Citerio, Mark van den Boogaard, Johanna Hästbacka, Matthias Haenggi, Kirsten Colpaert, Louise Rose, Marija Barbateskovic, Theis Lange, Aksel Jensen, Martin B Krog, Ingrid Egerod, Helle L Nibro, Jørn Wetterslev, Anders Perner
PURPOSE: We assessed the prevalence and variables associated with haloperidol use for delirium in ICU patients and explored any associations of haloperidol use with 90-day mortality. METHODS: All acutely admitted, adult ICU patients were screened during a 2-week inception period. We followed the patient throughout their ICU stay and assessed 90-day mortality. We assessed patients and their variables in the first 24 and 72 h in ICU and studied their association together with that of ICU characteristics with haloperidol use...
May 16, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29759351/dysbindin-1-contributes-to-prefrontal-cortical-dendritic-arbor-pathology-in-schizophrenia
#4
Glenn T Konopaske, Darrick T Balu, Kendall T Presti, Grace Chan, Francine M Benes, Joseph T Coyle
Deep layer III pyramidal cells in the dorsolateral prefrontal cortex (DLPFC) from subjects with schizophrenia and bipolar disorder previously were shown to exhibit dendritic arbor pathology. This study sought to determine whether MARCKS, its regulatory protein dysbindin-1, and two proteins, identified using microarray data, CDC42BPA and ARHGEF6, were associated with dendritic arbor pathology in the DLPFC from schizophrenia and bipolar disorder subjects. Using western blotting, relative protein expression was assessed in the DLPFC (BA 46) grey matter from subjects with schizophrenia (n = 19), bipolar disorder (n = 17) and unaffected control subjects (n = 19)...
May 11, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29758999/movement-disorders-associated-with-antipsychotic-medication-in-people-with-schizophrenia-an-overview-of-cochrane-reviews-and-meta-analysis
#5
Davide Martino, Vikram Karnik, Sydney Osland, Thomas R E Barnes, Tamara M Pringsheim
Movement disorders associated with antipsychotic medications are relatively common, stigmatising, and potentially disabling. Their prevalence in people with psychosis who are prescribed second-generation antipsychotics (SGAs) is uncertain, as is their level of recognition by clinicinas. We conducted meta-analyses of randomised controlled trials included in the Cochrane Database of Systematic Reviews on schizophrenia and schizophrenia-like psychoses to estimate the prevalence of new-onset dystonia, akathisia, parkinsonism, and tremor with SGAs (amisulpride, asenapine, aripiprazole, clozapine, olanzapine, paliperidone, quetiapine, risperidone, L-sulpiride, and ziprasidone) approved in Canada and the UK, comparing them with haloperidol and chlorpromazine...
January 1, 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29751018/differential-behavioral-and-glial-responses-induced-by-dopaminergic-mechanisms-in-the-inos-knockout-mice
#6
Ana Carolina Issy, Glauce Crivelaro Nascimento, Gabriel Henrique Dias de Abreu, Fabrine S Tristão, Elaine Del-Bel, Terence Duarte, Mariza Bortolanza
The interaction between distinctive nitric oxide synthase (NOS) isoforms and the dopamine system provides new avenues to the development of pharmacological tools for the pathophysiological conditions of the dopaminergic system. Our aim was to investigate the influences of dopamine-induced effects in inducible NOS knockout (iNOS KO) mice. In order to characterize iNOS KO mice phenotype, the animals were submitted to the basal analyses of motor, sensorimotor and sensorial abilities. Pharmacological challenging of the dopaminergic system included the investigation of amphetamine-induced prepulse inhibition (PPI) disruption, haloperidol-induced catalepsy, reserpine-induced oral involuntary movements and hyperlocomotion induced by amphetamine in reserpine treated mice...
May 8, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29749607/increasing-antipsychotic-dose-versus-switching-antipsychotic-for-non-response-in-schizophrenia
#7
REVIEW
Myrto T Samara, Elisabeth Klupp, Bartosz Helfer, Philipp H Rothe, Johannes Schneider-Thoma, Stefan Leucht
BACKGROUND: Many people with schizophrenia do not respond to an initially prescribed antipsychotic drug. In such cases, one treatment strategy could be to increase the antipsychotic dose; and another strategy could be to switch to a different antipsychotic drug. OBJECTIVES: To examine the efficacy of increasing the antipsychotic dose versus switching the antipsychotic drug in the treatment of non-responsive people with schizophrenia. SEARCH METHODS: We searched the Cochrane Schizophrenia Group Trials Register (10 June 2014, 6 October 2015, and 30 March 2017)...
May 11, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29746845/detection-of-stress-and-the-effects-of-central-nervous-system-depressants-by-gastrointestinal-smooth-muscle-electromyography-in-wakeful-rats
#8
K F Szűcs, G Grosz, M Süle, A Sztojkov-Ivanov, E Ducza, A Márki, A Kothencz, L Balogh, R Gáspár
AIMS: The altered gut-brain interaction can be in the background of functional gastrointestinal (GI) disorders. In the GI tract, the slow-wave myoelectric signals can be detected by electromyography (EMG). The aims of our study were to follow up the stress induced alteration in the GI tract by smooth muscle EMG in wakeful rats. MAIN METHODS: The GI tract myoelectric activity of male rats was measured by an electrode pair under the abdominal skin, the responses were detected and analyzed by a software using fast Fourier transformation...
May 7, 2018: Life Sciences
https://www.readbyqxmd.com/read/29744073/complex-visual-hallucinatory-experience-in-an-elderly-blind-woman-with-glaucoma-revisiting-charles-bonnet-syndrome
#9
Azan A Nyundo, Innocent R Mwombeki
For fear of being ridiculed, individuals with visual hallucinations hide their experiences and thus remain unrecognized and miss treatment. An elderly blind woman secondary to glaucoma experienced visual hallucinations accompanied by gross behavior disturbances. She improved with sodium valproate after haloperidol failed and remained relatively improved upon 3 months follow-up.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29739134/effects-of-tianeptine-on-adult-rats-following-prenatal-stress
#10
Hwayoung Lee, Hyung-Ki Kim, Jun-Tack Kwon, Young Ock Kim, Jonghoon Seo, Sanghyun Lee, Ik-Hyun Cho, Hak-Jae Kim
Objective: Exposing a pregnant female to stress during the critical period of embryonic fetal brain development increases the risk of psychiatric disorders in the offspring. The objective of this study was to investigate the effect of antidepressant tianeptine on prenatally stressed (PNS) rats. Methods: In this study, a repeated variable stress paradigm was applied to pregnant rats during the last week of gestation. To investigate the effects of antidepressant tianeptine on PNS rats, behavioral and protein expression analyses were performed...
May 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29737183/clozapine-toxicity-in-a-cyp2d6-poor-metaboliser-additive-effects-of-haloperidol-and-valproate-on-clozapine-metabolism
#11
Robert Reznik, Rena Yuan Yuan Chen, Phoebe Stanford
OBJECTIVE: To illustrate the complexities of clozapine metabolism with the use of therapeutic drug monitoring. METHODS: We describe a case of clozapine toxicity in a patient with schizophrenia treated with the combination of clozapine, valproate and haloperidol. RESULTS: A 24-year-old CYP2D6 poor metaboliser developed clozapine toxicity corresponding to the additive effects of haloperidol, and increasing clozapine and valproate doses. Saturation of metabolism, evidenced by a high clozapine/norclozapine ratio, was present at this time...
May 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29731635/antidopaminergic-medication-in-healthy-subjects-provokes-subjective-and-objective-mental-impairments-tightly-correlated-with-perturbation-of-biogenic-monoamine-metabolism-and-prolactin-secretion
#12
Tanja Veselinović, Ingo Vernaleken, Paul Cumming, Uwe Henning, Lina Winkler, Peter Kaleta, Michael Paulzen, Christian Luckhaus, Gerhard Gründer
Objectives: Off-label prescription of antipsychotics to patients without psychotic symptoms has become a routine matter for many psychiatrists and also some general practitioners. Nonetheless, little is known about the possibly detrimental effects of antidopaminergic medications on general psychopathology, subjective mental state, or a possible association with physiological parameters in nonpsychotic individuals. Methods: In this randomized, single-blinded study, groups of healthy volunteers (n=18) received low doses of reserpine, aripiprazole, haloperidol, or placebo on 7 successive days...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29723151/-the-effect-of-antipsychotic-drug-on-monoamine-receptors-in-peripheral-blood-mononuclear-cells-affinity-linked-mechanism
#13
A E Taraskina, A M Zabotina, R F Nasyrova, D N Sosin, K A Sosina, E E Ershov, M N Grunina, E M Krupitsky
Schizophrenia is one of the most serious and common mental disorders, which is characterized by high levels of pathogenic heterogeneity as well as neuroimmune abnormalities, which require treatment with antipsychotic drugs. Monoamines are one of the key neurotransmitters which play an important role in neuroimmune interactions of the human organism. We suggest that the quantity of the monoamine receptors on mononuclear cells of the peripheral blood (PBMCs) can be associated with the cytokine profile of patients...
March 2018: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/29720113/a-randomized-open-label-study-of-guideline-driven-antiemetic-therapy-versus-single-agent-antiemetic-therapy-in-patients-with-advanced-cancer-and-nausea-not-related-to-anticancer-treatment
#14
Janet Hardy, Helen Skerman, Paul Glare, Jennifer Philip, Peter Hudson, Geoffrey Mitchell, Peter Martin, Odette Spruyt, David Currow, Patsy Yates
BACKGROUND: Nausea/vomiting (N/V) not related to anti-cancer treatment is common in patients with advanced cancer. The standard approach to management is to define a dominant cause, and treat with an antiemetic selected through pathophysiologic knowledge of emetic pathways. High rates of N/V control have been reported using both etiology-based guideline-driven antiemetic regimens and an empiric approach using single agents in uncontrolled studies. These different approaches had never been formally compared...
May 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29717617/selegiline-nanoformulation-in-attenuation-of-oxidative-stress-and-upregulation-of-dopamine-in-the-brain-for-the-treatment-of-parkinson-s-disease
#15
Shobhit Kumar, Shweta Dang, Kuldeep Nigam, Javed Ali, Sanjula Baboota
Objective of the present study was to determine whether the prepared nanoemulsion would be able to deliver selegiline to the brain by intranasal route improving its bioavailability. Antioxidant activity, pharmacokinetic parameters and dopamine concentration were determined. Oxidative stress models which had Parkinson's disease like symptoms were used to evaluate the antioxidant activity of nanoemulsion loaded with selegiline in vivo. The antioxidant activity was evaluated by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay and reducing power assay which showed high scavenging efficiency for selegiline nanoemulsion compared to pure selegiline...
May 2, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29716850/methylphenidate-induced-hepatotoxicity-in-rats-and-its-reduction-by-buspirone
#16
Nausheen Alam, Rahila Ikram
Methylphenidate is commonly use for the treatment of attention deficit hyperactivity disorder (ADHD), but its long term use was found to produce hepatic necrosis in mice. Purpose of this study was to investigate that co-administration of buspirone (drug which attenuates methylphenidate induced sensitization) may attenuate methylphenidate-induced hepatotoxic effects and to determine the effect of challenge dose of haloperidol (D2 antagonist that blocks the effects of methylphenidate in case of intoxication) on SGPT and SGOT levels in methylphenidate treated rats...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29715183/c-fos-expression-in-the-hypothalamic-paraventricular-nucleus-after-a-single-treatment-with-a-typical-haloperidol-and-nine-atypical-antipsychotics-a-pilot-study
#17
Alexander Kiss
OBJECTIVE: The aim of the present study was to find out whether acute effect of different doses of selected antipsychotics including aripiprazole (ARI), amisulpride (AMI), asenapine (ASE), haloperidol (HAL), clozapine (CLO), risperidone (RIS), quetiapine (QUE), olanzapine (OLA), ziprasidone (ZIP), and paliperidone (PAL) may have a stimulatory impact on the c-Fos expression in the hypothalamic paraventricular nucleus (PVN) neurons. METHODS: Adult male Wistar rats weighing 280-300 g were used...
April 1, 2018: Endocrine Regulations
https://www.readbyqxmd.com/read/29713100/do-long-acting-injectable-antipsychotics-prevent-or-delay-hospital-readmission
#18
Thomas J Maestri, Lisa M Mican, Heather Rozea, Jamie C Barner
Introduction: Long-acting injectable (LAI) antipsychotics were developed as a way to decrease pill burden and simplify medication regimens by allowing less frequent administration to assist with medication adherence. Methods: The purpose of this study was to determine whether LAI antipsychotics prevent or delay hospital readmission in patients with a known history of medication non-adherence. The study is a retrospective evaluation of 240 men and women 18-65 years of age diagnosed with bipolar disorder, schizophrenia, or schizoaffective disorder discharged from an inpatient state hospital over a 2 year period of time on a LAI antipsychotic (fluphenazine LAI, haloperidol LAI, risperidone LAI or paliperidone LAI) or oral antipsychotic...
March 13, 2018: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29710504/pharmacological-interaction-of-galphimia-glauca-extract-and-natural-galphimines-with-ketamine-and-haloperidol-on-different-behavioral-tests
#19
Mayra Alejandra Santillán-Urquiza, Maribel Herrera-Ruiz, Alejandro Zamilpa, Enrique Jiménez-Ferrer, Rubén Román-Ramos, Jaime Tortoriello
Due to the high prevalence of psychiatric disorders and the prevalent side effects produced by the antipsychotic drugs available, it is necessary to search for new therapeutic options. Galphimia glauca has been used for many years in Mexican traditional medicine for treating mental diseases. From this plant, some compounds, denominated galphimines, have been discovered and have shown to possess the ability of modifying the frequency of discharge of dopaminergic neurons in the Ventral tegmental area. The objective of the present work was to evaluate the effect produced by the G...
April 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29704613/regional-brain-volume-changes-following-chronic-antipsychotic-administration-are-mediated-by-the-dopamine-d2-receptor
#20
Elisa Guma, Jill Rocchetti, Gabriel A Devenyi, Arnaud Tanti, Axel Mathieu, Jason P Lerch, Guillaume Elgbeili, Blandine Courcot, Naguib Mechawar, M Mallar Chakravarty, Bruno Giros
BACKGROUND: Neuroanatomical alterations are well established in patients suffering from schizophrenia, however the extent to which these changes are attributable to illness, antipsychotic drugs (APDs), or their interaction is unclear. APDs have been extremely effective for treatment of positive symptoms in major psychotic disorders. Their therapeutic effects are mediated, in part, through blockade of D2-like dopamine (DA) receptors, i.e. the D2, D3 and D4 dopamine receptors. Furthermore, the dependency of neuroanatomical change on DA system function and D2-like receptors has yet to be explored...
April 25, 2018: NeuroImage
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