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https://www.readbyqxmd.com/read/28565829/effects-of-negative-pressure-wound-therapy-combinedwith-microplasma-on-treating-wounds-of-ulcer-and-the-expression-of-heat-shock-protein-90
#1
Zhihong Li, Qihong Wang, Wenxin Mi, Mei Han, Fei Gao, Guangyan Niu, Yindong Ma
The effects of negative pressure wound therapy (NPWT) combined with microplasma on treating wounds of ulcer, and blood perfusion of wound-healing of interface, angiogenesis and the expressions of heat shock protein 90 (HSP90) were explored. We selected continuously 64 patients with wounds of ulcer. The patients were divided into the conventional treatment group (just medical foam dressing and 1% silver sulfadiazine cream for dressing changes) (n=20 cases), the NPWT group (n=22 cases) and the combination group (NPWT combined with microplasma) (n=22 cases), and compared the effects...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28459181/effect-of-negative-pressure-wound-therapy-cellular-fibronectin-and-transforming-growth-factor-%C3%AE-1-expression-in-diabetic-foot-wounds
#2
Shao Ling Yang, Lv Yun Zhu, Rui Han, Lei Lei Sun, Jing Tao Dou
BACKGROUND: Chronic diabetic foot wounds are a leading cause of amputation, morbidity, and hospitalization for patients with diabetes. Negative-pressure wound therapy (NPWT) can putatively facilitate wound healing, but the underlying mechanisms remain unclear. Cellular fibronectin (cFN) and transforming growth factor-β1 (TGF-β1) play an important role in wound healing. This prospective randomized controlled trial evaluated the effects of NPWT on the production of cFN and the expression of TGF-β1 in diabetic foot wounds of patients...
April 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28458556/evaluation-of-negative-pressure-wound-therapy-for-patients-with-diabetic-foot-ulcers-systematic-review-and-meta-analysis
#3
REVIEW
Si Liu, Chao-Zhu He, Yan-Ting Cai, Qiu-Ping Xing, Ying-Zhen Guo, Zhi-Long Chen, Ji-Liang Su, Li-Ping Yang
OBJECTIVES: The aim of this study was to perform an updated systematic review and meta-analysis to assess the clinical efficacy, safety, and cost-effectiveness of negative-pressure wound therapy (NPWT) in the treatment of diabetic foot ulcers (DFUs). METHODS: We searched the Cochrane Library, MEDLINE, EMBASE, Ovid, and Chinese Biological Medicine databases up to June 30, 2016. We also manually searched the articles from reference lists of the retrieved articles, which used the NPWT system in studies of vacuum-assisted closure therapy...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28252337/accelerated-wound-healing-with-combined-npwt-and-ipc-a-case-series
#4
Kristian Arvesen, Camilla Bak Nielsen, Karsten Fogh
Negative pressure wound therapy (NPWT) and intermittent pneumatic compression (IPC) have traditionally been used in patients with chronic complicated non-healing wounds. The aim of this study (retrospective case series) was to describe the use of NPWT in combination with IPC in patients with a relatively short history (2-6 months) of ulcers. All wounds showed improved healing during the treatment period with marked or moderate reduction in ulcer size, and granulation tissue formation was markedly stimulated...
March 2017: British Journal of Community Nursing
https://www.readbyqxmd.com/read/28058229/systematic-review-of-the-negative-pressure-wound-therapy-in-kidney-transplant-recipients
#5
Badri Man Shrestha
AIM: To review negative pressure wound therapy (NPWT) as an important addition to the conventional methods of wound management. METHODS: A systematic review, performed by searching the PubMed, EMBASE and Cochrane Library databases, showed 11 case reports comprising a total of 22 kidney transplantation (KT) patients (range, 1 to 9), who were treated with NPWT. Application of NPWT was associated with successful healing of wounds, leg ulcer, lymphocele and urine leak from ileal conduit...
December 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/28043851/negative-pressure-wound-therapy-in-orthopaedic-surgery
#6
REVIEW
N Robert
Negative pressure wound therapy (NPWT) consists in applying subatmospheric pressure to a wound that is sealed off by a specially designed dressing and connected by a tube to a suction pump and drainage collection system. Skin defects are extremely common in orthopaedic and trauma surgery. NPWT is valuable across a range of indications. Proven effects include an increase in blood flow, stimulation of angiogenesis, and a decrease in wound surface area. NPWT can be used to treat post-traumatic and surgical wounds, burns, and chronic wounds such as pressure sores and ulcers...
December 30, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28003941/negative-pressure-wound-therapy-with-instillation-in-a-chronic-non-healing-right-hip-trochanteric-pressure-ulcer
#7
Kevin W Broder, Brian Nguyen, Richard M Bodor
Complex pressure ulcer wound sites often present with a wide scope of barriers to healing ranging from high colonization of multi-drug-resistant pathogens to tortuous internal anatomy which make the wound recalcitrant to traditional wound care including standard negative pressure wound therapy (NPWT). Negative pressure wound therapy with instillation (NPWTi-d) provides an opportunity to manage and heal wounds with indications not met by standard NPWT such as cavitating wounds with complex undermining and tunneling...
November 14, 2016: Curēus
https://www.readbyqxmd.com/read/27984596/potential-future-applications-for-negative-pressure-wound-therapy-and-installation-devices
#8
Reuben A Falola, Caitlin M Ward, Madison J Kim, Tammer Elmarsafi, John S Steinberg, Karen K Evans, Christopher E Attinger, Paul J Kim
Negative-pressure wound therapy (NPWT) applies vacuum pressure to a wound bed sealed by an adhesive dressing to improve wound healing. A cleansing solution, often antibiotics or saline, may be instilled into the wound bed concurrently and removed via suction, thus enhancing the therapeutic effect. The therapeutic effect results from improved blood flow and removal of inflammatory factors. Since 1995, the FDA has approved NPWT for medical use. Since then, this technology has been applied to different types of wounds, including diabetic and decubitus ulcers and postsurgical incisional wounds...
December 16, 2016: Surgical Technology International
https://www.readbyqxmd.com/read/27883358/negative-pressure-wound-therapy-inhibits-inflammation-and-upregulates-activating-transcription-factor-3-and-downregulates-nuclear-factor-%C3%AE%C2%BAb-in-diabetic-patients-with-foot-ulcerations
#9
T Wang, R He, J Zhao, J C Mei, M Z Shao, Y Pan, J Zhang, H S Wu, M Yu, W C Yan, L M Liu, F Liu, W P Jia
BACKGROUND: Negative pressure wound therapy (NPWT) is one of the most important treatments for diabetic foot, but the underlying mechanisms of its benefits still remain elusive. This study aims to evaluate the inflammatory signals involved in the effects of negative pressure therapy on diabetic foot ulcers. METHODS: We enrolled 22 patients with diabetic foot ulceration, 11 treated with NPWT and the other 11 treated with traditional debridement. All patients were treated and observed for 1 week...
November 24, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27827282/primary-wound-closure-of-diabetic-foot-ulcers-by-debridement-and-stitching
#10
COMPARATIVE STUDY
M E Ahmed, M S Mohammed, S I Mahadi
OBJECTIVE: The role of stitching in healing diabetic foot ulcers (DFUs) has little attention, with few reports published on the technique. This study aimed to report on the role of stitching in healing of neuropathic DFUs. METHOD: This comparative study was between patients with diabetes with neuropathic foot ulcers who had undergone wound stitching and those on conventional wound care. The study was carried in Jabir Abu Eliz Diabetic Center Khartoum (JADC) during between January 1 2011 and January 1 2013...
November 2, 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27785377/peroxy-pyruvic-acid-containing-topical-anti-infective-a-potential-candidate-for-a-wound-instillation-solution
#11
Edwin D Neas, Julie A Dunn, Evelyn Dimaano Silva, A Morgan Chambers, Gary J Luckasen, Adam Jaskowiak
Objective: Evaluate the therapeutic properties of a peroxy pyruvic acid (PPA)-containing topical anti-infective in a human ex-vivo model that replicates the natural conditions of a human chronic wound. Approach: Wound material was extracted from patients with nonhealing diabetic ulcers, venous stasis ulcers, and arterial wounds. Microbial species were identified, and wound colonization was quantified. Extracted samples were then exposed to a PPA-containing topical anti-infective as an instillation solution with negative pressure wound therapy NPWT at concentrations of 1,000, 1,500, or 2,500 ppm for a period of 1, 5, or 10 min to determine the effect of exposure on isolated pathogens, including effect on proteins...
October 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27589361/the-effect-of-a-bacteria-and-fungi-binding-mesh-dressing-on-the-bacterial-load-of-pressure-ulcers-treated-with-negative-pressure-wound-therapy-a-pilot-study
#12
Marino Ciliberti, Francesco De Lara, Gianfranco Serra, Felice Tafuro, Francesco Maria Iazzetta, Alessia Filosa, Rosa Scognamiglio, Giorgia Ciliberti, Maria Rosaria Veneri
OBJECTIVE: This study was designed to clinically evaluate the efficacy of a bacteria- and-fungi-binding mesh (BFBM) dressing to modify the bacterial load of pressure ulcers (PUs) of categories 3 and 4, when used as a wound contact layer (WCL) during negative pressure wound therapy (NPWT). METHODS: This was an observational single-centre study in patients with PUs of categories 3 or 4, who were treated with NPWT. Patients were observed for 7 days and received NPWT at -80 mm Hg with the BFBM dressing as the WCL...
November 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27429242/influence-of-negative-pressure-wound-therapy-on-tissue-oxygenation-in-diabetic-feet
#13
Jae-A Jung, Ki-Hyun Yoo, Seung-Kyu Han, Ye-Na Lee, Seong-Ho Jeong, Eun-Sang Dhong, Woo-Kyung Kim
OBJECTIVE: Negative-pressure wound therapy (NPWT) has become a common wound care treatment modality for a variety of wounds. Several previous studies have reported that NPWT increases blood flow in the wound bed. However, NPWT might decrease tissue oxygenation in the wound bed because the foam sponge of NPWT compresses the wound bed under the influence of the applied negative pressure. Adequate tissue oxygenation is an essential consideration during diabetic foot management, and the foot is more sensitive to ischemia than any other region...
August 2016: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/27374835/ten-year-analyses-of-the-german-drg-data-about-negative-pressure-wound-therapy
#14
Olga von Beckerath, Alexander Zapenko, Joachim Dissemond, Knut Kröger
Exact data regarding the clinical role of negative pressure wound therapy (NPWT) for wound care in a specific country are not available. Thus, we analysed the use of NPWT in hospitalised patients in Germany. Detailed lists of all hospitalised cases treated with NPWT in Germany for each of the years from 2005 to 2014 were obtained from the Federal Statistical Office, as well as lists of the 15 most frequent principal and additional diagnoses documented with NPWT in 2014. Within the 10-year time period of the study, the number of cases treated with NPWT increased by 349%, from 37 053 in 2005 to 129 269 in 2014...
June 2017: International Wound Journal
https://www.readbyqxmd.com/read/27347212/use-of-negative-pressure-wound-therapy-as-an-adjunct-to-the-treatment-of-extremity-soft-tissue-sarcoma-with-ulceration-or-impending-ulceration
#15
Y U Chen, Song-Feng Xu, Ming Xu, Xiu-Chun Yu
Major wound complications of the extremities, following wide tumor resection and reconstruction for soft-tissue sarcomas (STSs), remain a challenge for limb-sparing surgery. Furthermore, STSs with ulceration or impending ulceration predispose patients to an increased risk of post-operative infection. The present study was conducted to assess the efficacy of negative pressure wound therapy (NPWT) in preventing wound complications associated with surgical treatment of STSs with ulceration or impending ulceration, in patients treated between February 2012 and January 2013...
July 2016: Oncology Letters
https://www.readbyqxmd.com/read/27246708/randomized-controlled-trial-of-prophylactic-negative-pressure-wound-therapy-at-ostomy-closure-for-the-prevention-of-delayed-wound-healing-and-surgical-site-infection-in-patients-with-ulcerative-colitis
#16
RANDOMIZED CONTROLLED TRIAL
Motoi Uchino, Kei Hirose, Toshihiro Bando, Teruhiro Chohno, Yoshio Takesue, Hiroki Ikeuchi
BACKGROUND/AIMS: Although negative-pressure wound therapy (NPWT) is likely advantageous for wound healing, the efficacy and safety of its prophylactic use remain unclear for digestive surgery. We performed a prospective randomized controlled study to evaluate the efficacy and safety of this procedure during ileostomy closure. METHODS: We conducted a prospective, randomized study between November 2014 and September 2015. Patients with ulcerative colitis scheduled to undergo ileostomy closure with purse-string suture (PSS) were randomly divided into groups with or without NPWT...
2016: Digestive Surgery
https://www.readbyqxmd.com/read/27212250/the-bagautdinov-dressing-method-negative-pressure-wound-therapy-in-a-patient-with-an-allergy-to-acrylate-adhesive
#17
David A Daar, Garrett A Wirth, Gregory Rd Evans, Melissa Carmean, Ian L Gordon
Current embodiments of negative pressure wound therapy (NPWT) create a hermetically sealed chamber at the surface of the body using polyurethane foam connected to a vacuum pump, which is then covered by a flexible adhesive drape. Commercially available NPWT systems routinely use flexible polyethylene films that have a sticky side, coated with the same acrylate adhesives used in other medical devices such as ECG leads and grounding pads. Severe reactions to the acrylate adhesives in these other devices, although uncommon, have been reported...
May 22, 2016: International Wound Journal
https://www.readbyqxmd.com/read/27130382/intralesional-application-of-epidermal-growth-factor-in-limb-threatening-ischemic-diabetic-foot-ulcers
#18
Şamil Aktaş, Selçuk Baktıroğlu, Levent Demir, Önder Kılıçoğlu, Murat Topalan, Erdem Güven, Bengüsu Mirasoğlu, Fatih Yanar
OBJECTIVE: The intralesional injection of recombinant human epidermal growth factor (EGF-IL), a new therapy, has been claimed to prevent major amputations in advanced diabetic foot lesions. In this study, the efficacy of EGF-IL on advanced diabetic foot ulcers (DFU) was reviewed. METHODS: Intralesional 75 µg EGF application (Heberprot-P® 75, Heber Biotec, Havana, Cuba) to 12 diabetic foot lesions in 11 patients (8 males, 3 females; mean age: 62.2±10.6 years) was evaluated...
2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27068343/human-acellular-dermal-wound-matrix-for-complex-diabetic-wounds
#19
P Rupert
OBJECTIVE: Diabetic ulcers are the most common foot injuries leading to lower-extremity amputation and the most common cause of non-traumatic lower extremity amputations in the industrialised world. Approximately 85% of all diabetes-related lower-extremity amputations are preceded by foot ulcers. When foot ulcers develop despite preventive measures, early and appropriate treatment should be initiated to help reduce the burden of diabetes-related amputations. Recent advances now offer these patients a regenerative process of restoring the wound with human integument by replacing damaged or missing tissue with similar tissue rather than scar formation...
April 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27064369/pressure-ulcer-management-in-paraplegic-patients-with-a-novel-negative-pressure-device-a-randomised-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
M K Dwivedi, R N Srivastava, A K Bhagat, R Agarwal, K Baghel, A Jain, S Raj
OBJECTIVE: A randomised controlled trial to compare negative pressure wound therapy (NPWT) using our innovative negative pressure device (NPD) and the standard pressure ulcer (PU) wound dressing of in traumatic paraplegia patients. METHOD: This study was conducted in the Department of Orthopaedic Surgery at King George's Medical University, Lucknow, India. Traumatic paraplegia patients with sacral pressure ulcers of stage 3 and 4 were randomised into two groups, receiving either standard wound dressings or NPWT with NPD...
April 2016: Journal of Wound Care
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