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https://www.readbyqxmd.com/read/28630860/regulation-of-matrix-metalloproteinase-2-secretion-from-scleral-fibroblasts-and-retinal-pigment-epithelial-cells-by-mir-29a
#1
Yingjie Zhang, Dan-Ning Hu, Yi Zhu, Hao Sun, Ping Gu, Dongqing Zhu, Jibo Zhou
PURPOSE: To identify an effective method to prevent myopia progression by characterizing the regulation of matrix metalloproteinase- (MMP-) 2 expression and its secretion from scleral fibroblasts and retinal pigment epithelium (RPE) cells by miR-29a. METHODS: The effects of miR-29a on the growth of scleral fibroblasts and RPE cells were assessed using the cell counting kit-8. The changes in MMP-2 mRNA levels in scleral fibroblasts and RPE cells after transfection with miR-29a mimics or inhibitor were measured by quantitative PCR...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28628143/-prevalence-of-reduced-visual-acuity-among-chinese-han-students-in-2014
#2
Y Song, P J Hu, Y H Dong, B Zhang, J Ma
OBJECTIVE: To analyze the prevalence of reduced visual acuity (VA) and to examine the association between reduced visual acuity and influencing factors among Chinese Han students, so as to provide bases for the prevention and treatment of reduced visual acuity. METHODS: Subjects were from 2014 Chinese National Surveys on Students' Constitution and Health (CNSSCH). In this survey, 261 832 Han students aged 7-22 years participated. Unaided distance VA was measured using a retro-illuminated lgMAR chart with tumbling-E optotypes...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28626818/astigmatic-treatment-with-photorefractive-keratectomy-investigations-of%C3%A2-non-keratometric-ocular-astigmatism
#3
Alireza Peyman, Zahra Dastborhan, Mohammadreza Peyman
PURPOSE: To evaluate the effect of non-keratometric ocular astigmatisms on visual and refractive outcomes after photorefractive keratectomy (PRK) for correction of myopic astigmatisms. METHODS: Seventy one eyes of 36 subjects were enrolled in this study. Patients underwent PRK for treatment of myopia. Subjects were evaluated for refractive error, keratometry, and visual acuity before and six months after surgery. Pre- and post-op non-keratometric astigmatisms were calculated by vectorial analysis of the difference between the corneal plane refractive astigmatism and keratometric astigmatism...
June 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28612330/endothelial-cell-changes-after-photorefractive-keratectomy-with-graded-usage-of-mitomycin-c
#4
Hamid Gharaee, Siamak Zarei-Ghanavati, Reza Alizadeh, Mojtaba Abrishami
PURPOSE: To compare differences in the endothelial cells before and after photorefractive keratectomy (PRK) for myopia with refractive error graded mitomycin C (MMC) application. METHODS: In a prospective randomized clinical trial, forty-eight myopic patients referred to Khatam-al-Anbia Eye Hospital, Mashhad, Iran, for PRK. Patients were treated with PRK by a Bausch and Lomb Technolas 217z excimer laser (Bausch and Lomb, Rochester, NY). MMC was applied after PRK 5 s for each diopter of spherical equivalent myopic refractive error corrected...
June 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28602573/dopamine-signaling-and-myopia-development-what-are-the-key-challenges
#5
REVIEW
Xiangtian Zhou, Machelle T Pardue, P Michael Iuvone, Jia Qu
In the face of an "epidemic" increase in myopia over the last decades and myopia prevalence predicted to reach 2.5 billion people by the end of this decade, there is an urgent need to develop effective and safe therapeutic interventions to slow down this "myopia booming" and prevent myopia-related complications and vision loss. Dopamine (DA) is an important neurotransmitter in the retina and mediates diverse functions including development, visual signaling, and refractive development. Inspired by the convergence of epidemiological and animal studies in support of the inverse relationship between outdoor activity and risk of developing myopia and by the close biological relationship between light exposure and dopamine release/signaling, we felt it is timely and important to critically review the role of DA in myopia development...
June 7, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28600301/features-of-optical-coherence-tomography-predictive-of-choroidal-neovascularisation-treatment-response-in-pathological-myopia-in-association-with-fluorescein-angiography
#6
Dong Hyun Lee, Hyun Goo Kang, Sung Chul Lee, Min Kim
BACKGROUND/AIMS: The aim of this study was to evaluate the usefulness of several optical coherence tomography (OCT) findings to estimate choroidal neovascularisation (CNV) activity in pathological myopia using fluorescein angiography (FA) as a reference. METHODS: This was a single-centre, retrospective study. The medical records of patients with active myopic CNV who received intravitreal bevacizumab treatment were reviewed. Parameters to monitor CNV activity were morphological features of CNV on OCT, such as CNV height, central foveal thickness, intraretinal cysts, subretinal fluid, fuzziness of the CNV border, CNV network area on FA, and haemorrhage or exudation on fundus photo...
June 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28599337/-pediatric-retinal-detachment
#7
Petra Meier
The number of retinal detachments in children is rarely compared to the number of retinal detachments in adults; only 3 - 7% occur in children. The main predisposing factors are trauma, myopia, hereditary vitreoretinopathies, retinopathy of prematurity, malformations and Coats' disease. The most frequent paediatric retinal detachments are trauma-associated and vitreoretinopathies are the most common cause of inherited retinal detachment. Disease-specific surgical treatments are discussed. Episcleral buckling surgery should be the preferred method in any case of clear lens, especially for treatment of oradialysis and well-defined localization of peripherally retinal tears...
June 9, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28590964/overview-of-the-complications-of-high-myopia
#8
Yasushi Ikuno
High myopia is very common and one of the major causes of social blindness, especially in East Asian countries. It is characterized by axial length elongation, and induces various specific complications, including cataract formation, retinal detachment from peripheral retinal tears, myopic foveoschisis, macular hole with or without retinal detachment, peripapillary deformation, dome-shaped macula, choroidal/scleral thinning, myopic choroidal neovascularization, and glaucoma. This article will review these complications and discuss the current concepts relating to these complications and their treatments...
January 24, 2017: Retina
https://www.readbyqxmd.com/read/28590317/neovascularization-secondary-to-high-myopia-imaged-by-optical-coherence-tomography-angiography
#9
Elsa Bruyère, Alexandra Miere, Salomon Yves Cohen, David Martiano, Anne Sikorav, Andrada Popeanga, Oudy Semoun, Giuseppe Querques, Eric H Souied
PURPOSE: To describe the optical coherence tomography angiography (OCTA) characteristics of active myopic choroidal neovascularization (CNV) and to compare its sensitivity versus fluorescein angiography and spectral-domain optical coherence tomography. METHODS: Consecutive highly myopic patients complicated with active myopic CNV were prospectively included. The OCTA features were analyzed and correlated with the findings of conventional imaging (spectral-domain optical coherence tomography and fluorescein angiography)...
January 11, 2017: Retina
https://www.readbyqxmd.com/read/28584936/a-review-of-nitric-oxide-for-the-treatment-of-glaucomatous-disease
#10
REVIEW
Joah Aliancy, W Daniel Stamer, Barbara Wirostko
Glaucoma is the leading cause of irreversible blindness worldwide, affecting 64.3 million people. An estimated 60.5 million people are affected by primary open angle glaucoma globally, and this will increase to 111.8 million by 2040. The definition of glaucoma has evolved greatly over time. Although multiple risk factors such as ischemia, inflammation, myopia, race, age and low ocular perfusion pressure may play a role, intraocular pressure (IOP) is still the main risk factor we can easily identify and modify...
June 5, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28577860/glaucoma
#11
REVIEW
Jost B Jonas, Tin Aung, Rupert R Bourne, Alain M Bron, Robert Ritch, Songhomitra Panda-Jonas
Glaucoma is a heterogeneous group of diseases characterised by cupping of the optic nerve head and visual-field damage. It is the most frequent cause of irreversible blindness worldwide. Progression usually stops if the intraocular pressure is lowered by 30-50% from baseline. Its worldwide age-standardised prevalence in the population aged 40 years or older is about 3·5%. Chronic forms of glaucoma are painless and symptomatic visual-field defects occur late. Early detection by ophthalmological examination is mandatory...
May 31, 2017: Lancet
https://www.readbyqxmd.com/read/28545414/the-observation-during-small-incision-lenticule-extraction-for-myopia-with-corneal-opacity
#12
Shaowei Zhang, Haipeng Xu, Ke Zheng, Jing Zhao, Weijun Jian, Meiyan Li, Xingtao Zhou
BACKGROUND: To evaluate the feasibility and efficacy of small incision lenticule extraction (SMILE) in the treatment of myopia with corneal opacity. METHODS: To evaluate the treatment of myopia with corneal opacity, 9 patients (4 males, 5 females) who underwent SMILE were enrolled in this prospective clinical study. One eye of each patient was treated. The results of laser scanning and lenticule extraction were observed during the surgery, and the surgical videos were again reviewed after surgery...
May 25, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28539273/ion-paired-pirenzepine-loaded-micelles-as-an-ophthalmic-delivery-system-for-the-treatment-of-myopia
#13
Yanan Li, Yong Zhang, Pengmei Li, Gujie Mi, Jiasheng Tu, Linlin Sun, Thomas J Webster, Yan Shen
Myopia is one of the most common ocular disorders for which standard treatments, such as refractive surgery, often involve invasive procedures. Pirenzepine (PRZ), a muscarinic receptor antagonist, has been recognized as a promising candidate for the treatment of myopia, but possesses poor ocular bioavailability. The overall objective of this study was to prepare PRZ-sorbic acid complexes suitable to be encapsulated into micelles with high efficiency for optimal ophthalmic delivery. The results demonstrated that sorbic acid, used as the counter ion, had the most significant effects in increasing the octanol-water distribution coefficient of PRZ as well as improving its corneal permeability in vitro among various counter ions tested...
May 21, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28539146/keratoconus-in-civil-aviation-pilots-in-a-report-of-six-cases
#14
Albert Rebello, Bênesson Rodrigues, Marcos Pereira
BACKGROUND: Keratoconus is a progressive noninflammatory ectatic corneal dystrophy, characterized by corneal thinning and increased curvature with central or paracentral tapered protrusion. Such changes in corneal morphology induce irregular astigmatism and myopia, resulting in visual acuity impairment. This report assesses cases in which keratoconus is not an absolute disabling condition for civil aviation pilots. METHODS: Six cases of keratoconus in active pilots are presented...
June 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28537642/orthokeratology-treatment-in-pediatric-myopia
#15
EDITORIAL
Leonard B Nelson
No abstract text is available yet for this article.
May 1, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28534320/infectious-keratitis-and-orthokeratology-lens-use-a-systematic-review
#16
REVIEW
Ka Wai Kam, Wing Yung, Gabriel Ka Hin Li, Li Jia Chen, Alvin L Young
PURPOSE: Myopia is a prevalent condition among Asians. Orthokeratology lens has gained popularity as a method of myopia control. This systematic review is to summarize the clinical profile of infectious keratitis in association with orthokeratology lens wear. METHODS: We searched in the PubMed and EMBASE for articles adopting the search strategy "(orthokeratology lens OR orthokeratology) AND (bacterial eye infection OR keratitis OR cornea ulcer OR microbial keratitis OR bacterial keratitis)", from the start date of the databases to August 23, 2016...
May 22, 2017: Infection
https://www.readbyqxmd.com/read/28525563/omics-biomarkers-in-ophthalmology
#17
Susette Lauwen, Eiko K de Jong, Dirk J Lefeber, Anneke I den Hollander
"Omics" refers to high-throughput analyses of genes, proteins, or metabolites in a biological system, and is increasingly used for ophthalmic research. These system-based approaches can unravel disease-related processes and are valuable for biomarker discovery. Furthermore, potential therapeutic targets can be identified based on omics results, and targeted follow-up experiments can be designed to gain molecular understanding of the disease and to test new therapies. Here, we review the application of omics techniques in eye diseases, focusing on age-related macular degeneration (AMD), diabetic retinopathy (DR), retinal detachment (RD), myopia, glaucoma, Fuchs' corneal dystrophy (FCD), cataract, keratoconus, and dry eyes...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28503431/a-pilot-study-of-intraocular-lens-explantation-in-69-eyes-in-chinese-patients
#18
Fang Chai, Bo Ma, Xin-Guang Yang, Juan Li, Mei-Fang Chu
AIM: To study the effects of intraocular lens (IOL) explantation and demographic characteristics. METHODS: Retrospective non-comparative case series. Clinical data recorded from patient charts included the following: demographic, preoperative and postoperative characteristics; complications; surgical methods, and changes in visual acuity. RESULTS: A total of 69 eyes in 67 Chinese patients who received IOL explants were studied. The patients' mean age at the time of explantation was 46...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28503426/expression-and-role-of-specificity-protein-1-in-the-sclera-remodeling-of-experimental-myopia-in-guinea-pigs
#19
Bo Jiang, Zhang-You Wu, Zi-Cheng Zhu, Gen-Jie Ke, Yue-Chun Wen, Si-Qin Sun
AIM: To study the expression of collagen I and transcription factor specificity protein 1 (Sp1), a transforming growth factor-β1 (TGF-β1) downstream target, and reveal the impact of the TGF-β1-Sp1 signaling pathway on collagen remodeling in myopic sclera. METHODS: Seventy-five 1-week-old guinea pigs were randomly divided into normal control, form deprivation myopia (FDM), and self-control groups. FDM was induced for different times using coverage with translucent latex balloons and FDM recovery was performed for 1wk after 4wk treatment; then, changes in refractive power and axial length were measured...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28494561/-observation-of-single-layered-inverted-internal-limiting-membrane-flap-technique-for-macular-hole-with-retinal-detachment-in-high-myopia
#20
C Z Xu, J H Wu, J W He, C Feng
Objective: To compare the outcome of pars plana vitrectomy (PPV) with a single-layered inverted internal limiting membrane (ILM) flap versus PPV with ILM peeling for the treatment of macular hole associated retinal detachment (MHRD) in high myopia. Methods: In a retrospective cohort study, PPV with 2 kinds of adjuvant surgical procedures were used in 35 moderately high myopia eyes with MHRD. These eyes were divided into 2 groups: group 1 (17 eyes) receiving PPV and ILM peeling and group 2 (18 eyes) receiving PPV with a single-layered inverted ILM flap...
May 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
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