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https://www.readbyqxmd.com/read/27911101/in-vivo-and-ex-vivo-evaluation-of-inflammation-and-apoptosis-induced-after-smile-procedures-for-different-refractive-error-range
#1
Leonardo Mastropasqua, Roberta Calienno, Claudia Curcio, Rodolfo Mastropasqua, Mario Nubile, Niccolò Salgari, Manuela Lanzini
PURPOSE: To detect corneal inflammation and apoptosis induced after small incision lenticule extraction (SMILE) at different refractive corrections for moderate to high values of myopia. METHODS: Fifty patients (50 eyes) suffering from medium to high myopia (spherical equivalent refraction from -3.75 to -10.00 diopters (D) with refractive astigmatism under -0.75 D) underwent SMILE in order to correct myopic error. In vivo evaluation was done by corneal confocal microscopy (IVCM) and ex vivo by immunohistochemistry...
December 2, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27898450/update-on-treating-high-myopia-with-implantable-collamer-lenses
#2
Xiaoying Wang, Xingtao Zhou
The purpose of this article is to provide updates on the treatment of high myopia with the implantable collamer lens (ICL). The ICL has become an important technique used in intraocular refractive surgery. With improvements in material, design, and application, the ICL has good efficacy, predictability, long-term safety and stability, manageable complications, and reversibility. More and more refractive surgeons are taking note of the ICL. This article reviews the material characteristics and the latest designs of the ICL along with the clinical applications, visual quality, and future development...
November 2016: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/27898442/epidemiology-of-pathologic-myopia-in-asia-and-worldwide
#3
Yee-Ling Wong, Seang-Mei Saw
The myopia epidemic in Asia is evident because the prevalence of high myopia among young adults is higher among Asian (6.8%-21.6%) compared with non-Asian populations (2.0%-2.3%). High myopia is linked to pathologic myopia (PM), which may cause irreversible visual impairment (VI). This review will highlight updates on the prevalence of PM and the associated VI from PM. The prevalence of PM among the middle-aged and elderly (0.9%-3.1%) is higher than the prevalence among children and adolescents (<0.2%). The PM lesions detected among older adults include advanced lesions, such as posterior staphyloma, chorioretinal atrophy, lacquer cracks, and Fuchs spot (in descending frequency of occurrence)...
November 2016: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/27898441/epidemiology-of-myopia
#4
Pei-Chang Wu, Hsiu-Mei Huang, Hun-Ju Yu, Po-Chiung Fang, Chueh-Tan Chen
Myopia is not a simple refractive error, but an eyesight-threatening disease. There is a high prevalence of myopia, 80% to 90%, in young adults in East Asia; myopia has become the leading cause of blindness in this area. As the myopic population increases globally, the severity of its impact is predicted. Approximately one fifth of the myopic population has high myopia (≥-6 diopters), which results in irreversible vision loss such as retinal detachment, choroidal neovascularization, cataracts, glaucoma, and macular atrophy...
November 2016: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/27893094/comparison-of-patient-specific-computational-modeling-predictions-and-clinical-outcomes-of-lasik-for-myopia
#5
Ibrahim Seven, Ali Vahdati, Vinicius Silbiger De Stefano, Ronald R Krueger, William J Dupps
Purpose: To assess the predictive accuracy of simulation-based LASIK outcomes. Methods: Preoperative and 3-month post-LASIK tomographic data from 20 eyes of 12 patients who underwent wavefront-optimized LASIK for myopia were obtained retrospectively. Patient-specific finite element models were created and case-specific treatment settings were simulated. Simulated keratometry (SimK) values and the mean tangential curvature of the central 3 mm (Kmean) were obtained from the anterior surfaces of the clinical tomographies, and computational models were compared...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27879184/-myopia-a-growing-health-problem
#6
J W L Tideman, J R Polling, A van der Schans, V J M Verhoeven, C C W Klaver
- Myopia is the eye disorder with the most rapid increase in prevalence worldwide. It develops in childhood, with a peak incidence between the ages of 13 to 15 years. - Especially high myopia, i.e. a refractive error of -6 diopters or more, increases the risk of permanent visual impairment during adulthood due to structural abnormalities of the retina and optic nerve.- The cause of myopia is complex. Lifestyle factors in childhood, such as limited time spent outdoors and close work - such as reading and smartphone usage - are risk factors...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27873014/binocular-function-changes-produced-in-response-to-overnight-orthokeratology
#7
Gema Felipe-Marquez, María Nombela-Palomo, Catalina Palomo-Álvarez, Isabel Cacho, Amelia Nieto-Bona
PURPOSE: To analyze the binocular function changes produced on subjects undergoing overnight orthokeratology (OK) treatment over short-term (3 months) and long-term (3 years) wear. METHODS: A prospective, longitudinal study on young adult subjects with low to moderate myopia was carried out. Binocular function was assessed by the following sequence of tests: Distance and near horizontal phoria (Von Graefe technique), distance and near horizontal vergence ranges (Risley rotary prisms), accommodative convergence/accommodation (AC/A) ratio (gradient method) and the near point of convergence (standard push-up technique)...
November 21, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27861262/tear-film-osmolarity-in-response-to-long-term-orthokeratology-treatment
#8
Amelia Nieto-Bona, María Nombela-Palomo, Gema Felipe-Márquez, Miguel A Teus
PURPOSE: To compare tear film osmolarity (TFO) measurements in non-contact lens (CL) wearers and wearers of hydrogel or overnight orthokeratology (OK) CLs, and to assess possible effects of long-term OK on TFO. METHODS: Overall, 108 subjects with moderate myopia participated in 2 experiments, and TFO was measured using the TearLab osmolarity system. In experiment 1, TFO measurements were made in 77 right eyes of 23 non-CL wearers, 26 hydrogel wearers, and 28 OK wearers...
November 16, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27853350/intravitreal-aflibercept-for-the-treatment-of-choroidal-neovascularization-associated-with-pathologic-myopia-a-pilot-study
#9
Andrii R Korol, Oleg S Zadorozhnyy, Volodymyr O Naumenko, Taras B Kustryn, Nataliya V Pasyechnikova
PURPOSE: To determine the efficacy of intravitreal aflibercept injections for the treatment of patients with choroidal neovascularization (CNV) associated with pathologic myopia. METHODS: In this uncontrolled, prospective cohort study, 31 eyes of 30 consecutive patients affected by CNV associated with pathologic myopia were treated with intravitreal aflibercept (2 mg) as needed following two initial monthly doses and observed over a 12-month follow-up period. The primary endpoint was change in best-corrected visual acuity (BCVA) at month 12, while central retinal thickness (CRT) on optical coherence tomography (OCT), neovascularization activity on fluorescein angiography, the number of aflibercept injections administered, and safety were examined as secondary endpoints...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27844100/-secondary-diseases-in-high-myopia
#10
F Ziemssen, W Lagrèze, B Voykov
BACKGROUND: Eyes with high myopia (axial length ≥ 26.5 mm) do not just have a different size. Due to morphological and structural changes there is a considerably increased risk for many different secondary diseases. OBJECTIVE: Determination of the incidence and mortality in high myopia, discussion of effects and clinical signs, presentation of treatment recommendations and counselling. MATERIAL AND METHODS: A systematic search of the literature was carried out and a discussion on basic principles and epidemiological investigations is presented...
November 14, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27843292/topography-modified-refraction-tmr-adjustment-of-treated-cylinder-amount-and-axis-to-the-topography-versus-standard-clinical-refraction-in-myopic-topography-guided-lasik
#11
Anastasios John Kanellopoulos
PURPOSE: To evaluate the safety, efficacy, and contralateral eye comparison of topography-guided myopic LASIK with two different refraction treatment strategies. SETTING: Private clinical ophthalmology practice. PATIENTS AND METHODS: A total of 100 eyes (50 patients) in consecutive cases of myopic topography-guided LASIK procedures with the same refractive platform (FS200 femtosecond and EX500 excimer lasers) were randomized for treatment as follows: one eye with the standard clinical refraction (group A) and the contralateral eye with the topographic astigmatic power and axis (topography-modified treatment refraction; group B)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27837278/the-role-of-micrornas-in-myopia
#12
REVIEW
Bo Jiang, Yanan Huo, Yangshun Gu, Jianyong Wang
PURPOSE: In recent years, research on microRNAs (miRNAs) has become popular because of the critical role these macromolecules play in post-transcriptional gene regulation. Recent efforts have been made to identify miRNAs and their possible roles in myopia. The aim of this review was to summarize the expression and function of miRNAs during the development of myopia. METHODS: In this article, we reviewed the current research on the mechanisms that regulate miRNA expression, the potential for miRNAs as a diagnostic biomarker for myopia, and the mechanisms by which miRNAs promote the development of myopia...
November 11, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27837267/-biological-mechanisms-of-myopia
#13
F Schaeffel
Recent studies have confirmed that the prevalence of myopia has increased in most countries, that the increase must be due to environmental factors and that myopia is closely linked to the level of education. Extensive close-up work with short viewing distances, little outdoor activity and continuous exposure to low illumination are currently considered the major factors. It remains unknown how close-up work can stimulate eye growth. Animal models provide the possibility to manipulate visual experiences and to observe subsequent changes in eye growth...
November 11, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27829051/scleral-cross-linking-using-riboflavin-uva-irradiation-for-the-prevention-of-myopia-progression-in-a-guinea-pig-model-blocked-axial-extension-and-altered-scleral-microstructure
#14
Shuai Liu, Shengjie Li, Bingjie Wang, Xiao Lin, Yi Wu, Hong Liu, Xiaomei Qu, Jinhui Dai, Xingtao Zhou, Hao Zhou
PURPOSE: To develop methods of collagen cross-linking (CXL) in the sclera for the treatment of progressive myopia and to investigate the biomechanical and histological changes that occur in as a result. METHODS: Twenty 14-day-old guinea pigs were divided into 3 groups: the cross-linking group (CL, n = 8), non cross-linking group (NCL, n = 8), and control group (n = 4). The scleras of the right eyes of the guinea pigs in the CL group were surgically exposed and riboflavin was dropped onto the irradiation zone for 20 seconds prior to ultraviolet-A (UVA) irradiation...
2016: PloS One
https://www.readbyqxmd.com/read/27802556/effect-of-osteopathic-cranial-manipulative-medicine-on-visual-function
#15
Mark E Sandhouse, Diana Shechtman, Gregory Fecho, Elena M Timoshkin
CONTEXT: The effects of osteopathic cranial manipulative medicine (OCMM) on visual function have been poorly characterized in the literature. Based on a pilot study conducted by their research group, the authors conducted a study that examined whether OCMM produced a measurable change in visual function in adults with cranial asymmetry. STUDY DESIGN: Randomized, controlled, double-blinded clinical trial. The intervention and control (sham therapy) were applied during 8 weekly visits, and participants in both groups received 8 weekly follow-up visits...
November 1, 2016: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/27779095/associations-between-diabetic-retinopathy-and-systemic-risk-factors
#16
N Wat, R Lm Wong, I Yh Wong
INTRODUCTION: Diabetes mellitus is a systemic disease with complications that include sight-threatening diabetic retinopathy. It is essential to understand the risk factors of diabetic retinopathy before effective prevention can be implemented. The aim of this review was to examine the association between diabetic retinopathy and systemic risk factors. METHODS: A PubMed literature search was performed up to May 2016 to identify articles reporting associations between diabetic retinopathy and systemic risk factors; only publications written in English were included...
October 24, 2016: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/27777827/quantitative-evaluation-of-microdistortions-in-bowman-s-layer-and-corneal-deformation-after-small-incision-lenticule-extraction
#17
Rushad Shroff, Mathew Francis, Natasha Pahuja, Leio Veeboy, Rohit Shetty, Abhijit Sinha Roy
PURPOSE: To quantitatively evaluate microdistortions in Bowman's layer and change in corneal stiffness after small incision lenticule extraction (SMILE). METHODS: This was a prospective, longitudinal, and interventional study. Thirty eyes of 30 patients were screened preoperatively and underwent SMILE for treatment of myopia with astigmatism. Visual acuity, refraction, optical coherence tomography (OCT; Bioptigen, Inc., Morrisville, NC) imaging of the layer and air-puff applanation (Corvis-ST, OCULUS Optikgeräte Gmbh, Germany) was performed before and after surgery (1 day, 1 week, and 1 month)...
October 2016: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/27776541/course-of-disease-in-multifocal-choroiditis-lacking-sufficient-immunosuppression-a-case-report
#18
Katharina Schroeder, Tobias Meyer-Ter-Vehn, Heidi Fassnacht-Riederle, Rainer Guthoff
BACKGROUND: Multifocal choroiditis with panuveitis is a rare disease. The educational merit of this case presentation results from the good documentation and the impressive ocular fundus pictures. CASE PRESENTATION: We illustrate the 3-year course of disease in a 22-year-old myopic white woman with multifocal choroiditis with panuveitis and secondary choroidal neovascularization. The activity of the disease was evaluated clinically by optical coherence tomography and fluorescein angiography...
October 24, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27771241/botulinum-toxin-for-treatment-of-restrictive-strabismus
#19
Pilar S Merino, Rebeca E Vera, Laura G Mariñas, Pilar S Gómez de Liaño, Jose V Escribano
PURPOSE: To study the types of acquired restrictive strabismus treated in a tertiary hospital and the outcome of treatment with botulinum toxin. METHODS: We performed a 10-year retrospective study of patients with restrictive strabismus aged ≥18 years who were treated with botulinum toxin. Treatment was considered successful if the final vertical deviation was ≤5 PD, horizontal deviation ≤10 PD, with no head turn or diplopia. RESULTS: We included 27 cases (mean age, 61...
October 19, 2016: Journal of Optometry
https://www.readbyqxmd.com/read/27757010/refractive-lenticule-extraction-relex-through-a-small-incision-smile-for-correction-of-myopia-and-myopic-astigmatism-current-perspectives
#20
Alper Ağca, Ahmet Demirok, Yusuf Yıldırım, Ali Demircan, Dilek Yaşa, Ceren Yeşilkaya, İrfan Perente, Muhittin Taşkapılı
Small-incision lenticule extraction (SMILE) is an alternative to laser-assisted in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) for the correction of myopia and myopic astigmatism. SMILE can be performed for the treatment of myopia ≤-12 D and astigmatism ≤5 D. The technology is currently only available in the VisuMax femtosecond laser platform. It offers several advantages over LASIK and PRK; however, hyperopia treatment, topography-guided treatment, and cyclotorsion control are not available in the current platform...
2016: Clinical Ophthalmology
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