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https://www.readbyqxmd.com/read/29438120/misight-assessment-study-spain-adverse-events-tear-film-osmolarity-and-discontinuations
#1
Alicia Ruiz-Pomeda, Belén Pérez-Sánchez, Francisco L Prieto-Garrido, Ramón Gutiérrez-Ortega, César Villa-Collar
OBJECTIVES: To assess the relative clinical success of MiSight contact lenses (CLs) (study group) and distance single-vision (SV) spectacles (control group) in children in terms of adverse events (AEs), discontinuations, and tear film osmolarity over a 2-year period. METHODS: Seventy-four subjects aged 8 to 12 with myopia of -0.75 to -4.00 D and astigmatism less than 1.00 D were randomly assigned to MiSight CLs or SV groups. Subjects were monitored at 6-month intervals over the course of 24 months and advised to report to the clinic immediately should AEs occur...
February 12, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29437727/unique-case-of-gyrate-atrophy-with-a-well-preserved-electroretinogram-erg
#2
Kirti M Jasani, Neil R A Parry, Graeme Black, Simon P Kelly
Gyrate atrophy is a rare autosomal recessive disorder caused by a mutation in the ornithine-δ-amino transferase gene. We present an interesting case of a 33-year-old woman who presented with increasing myopia, nyctalopia and failing vision. Examination revealed posterior subscapsular cataracts, narrowed peripheral visual fields and scalloped atrophic peripheral chorioretinal lesions. Blood investigations showed a raised plasma ornithine level at 917 μmol/L (normal range: 32-88 μmol/L) confirming the diagnosis of gyrate atrophy...
February 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29436656/early-quantitative-profiling-of-differential-retinal-protein-expression-in-lens-induced-myopia-in-guinea-pig-using-fluorescence-difference-two-dimensional-gel-electrophoresis
#3
Yi Wu, Carly Siu-Yin Lam, Dennis Yan-Yin Tse, Chi Ho To, Quan Liu, Sally A McFadden, Rachel Ka-Man Chun, King Kit Li, Jianfang Bian, Chuen Lam
The current study aimed to investigate the differential protein expression in guinea pig retinas in response to lens-induced myopia (LIM) before fully compensated eye growth. Four days old guinea pigs (n=5) were subjected to ‑4D LIM for 8 days. Refractive errors were measured before and at the end of the lens wear period. Ocular dimensions were also recorded using high‑frequency A‑scan ultrasonography. After the LIM treatment, retinas of both eyes were harvested and soluble proteins were extracted. Paired retinal protein expressions in each animal were profiled and compared using a sensitive fluorescence difference two‑dimensional gel electrophoresis...
February 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29408829/femtosecond-laser-assisted-small-incision-endokeratophakia-using-a-xenogeneic-lenticule-in-rhesus-monkeys
#4
Miao He, He Jin, Hong He, Hui Ding, Wei Wang, Liangping Liu, Chi Zhang, Xingwu Zhong
PURPOSE: To evaluate the feasibility and safety of xenogeneic endokeratophakia in rhesus monkeys and to explore the effects of a concave lenticule on refractive power. METHODS: Three adult New Zealand white rabbits and 6 healthy rhesus monkeys were used. The xenogenic concave grafts were created from the rabbits using a modified small incision lenticule extraction technique; after being cryopreserved in glycerol for 1 week, the grafts were implanted into the monkey recipient corneas...
March 2018: Cornea
https://www.readbyqxmd.com/read/29398233/superdiluted-atropine-at-0-01-reduces-progression-in-children-and-adolescents-a-5-year-study-of-safety-and-effectiveness
#5
M Diaz-Llopis, M D Pinazo-Durán
OBJECTIVE: To confirm the clinical security and effectiveness of the daily application of 0.01% superdiluted atropine eyedrops in the progression of myopia in children. MATERIAL AND METHODS: A total of 200 children 9-12 years of age were randomised into a treated group and a control without treatment. Refraction under cycloplegia was performed. RESULTS: Myopia progression of the treated group was -0.14±0.35 versus -0.65±0.54 in the control group without treatment...
February 1, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29390361/comparison-of-the-efficacy-of-intravitreal-ranibizumab-for-choroidal-neovascularization-due-to-pathological-myopia-with-and-without-a-dome-shaped-macula
#6
Bincui Cai, Jin Yang, Shuang Li, Linni Wang, Lu Chen, Xiaorong Li, Zhiqing Li
Ranibizumab injection in the treatment of choroidal neovascularization (CNV) secondary to pathologic myopia (PM) with and without a dome-shaped macula (DSM).Prospective observational study.A total of 24 patients (24 eyes) with angiographic evidence of CNV secondary to PM were divided into 2 groups: eyes with a DSM and eyes without DSM. All patients received a baseline intravitreal ranibizumab injection. Additional injections were considered at each follow-up visit. Best-corrected visual acuity (BCVA) and optical coherence tomography were tested monthly through 12 months of follow-up...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29378530/comparison-of-efficacy-between-anti-vascular-endothelial-growth-factor-vegf-and-laser-treatment-in-type-1-and-threshold-retinopathy-of-prematurity-rop
#7
Zijing Li, Yichi Zhang, Yunru Liao, Rui Zeng, Peng Zeng, Yuqing Lan
BACKGROUND: Retinopathy of Prematurity (ROP) is one of the most common causes of childhood blindness worldwide. Comparisons of anti-VEGF and laser treatments in ROP are relatively lacking, and the data are scattered and limited. The objective of this meta-analysis is to compare the efficacy of both treatments in type-1 and threshold ROP. METHODS: A comprehensive literature search on ROP treatment was conducted using PubMed and Embase up to March 2017 in all languages...
January 30, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29376229/investigation-of-the-changes-in-refractive-surgery-trends-in-korea
#8
Jong Ho Ahn, Dong Hyun Kim, Kyung Hwan Shyn
PURPOSE: To evaluate changes in clinical practice in the field of refractive surgery in Korea over the past 10 years. METHODS: A survey consisting of 59 multiple-choice questions regarding the preferred types of refractive surgery, excimer laser machine, and presbyopia surgery was mailed to 742 members of the Korean Society of Cataract and Refractive Surgery in January 2016, and 50 members responded to the survey. These data were compared with the 2005 or 2007 survey results...
January 25, 2018: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/29341978/assessment-of-clinical-trials-for-devices-intended-to-control-myopia-progression-in-children
#9
Marc W Robboy, Gene Hilmantel, Michelle E Tarver, Malvina B Eydelman
The increased prevalence of myopia in the United States and other regions of the world, and the sight-threatening problems associated with higher levels of myopia have led to great interest in research designed to reduce these rates. As most of the progression of myopia occurs in childhood, these investigations have been directed toward slowing the progression of myopia in children. Treatments described to potentially slow the progression of myopia have included pharmacological interventions, multifocal spectacles, and multifocal correction created by contact lenses...
January 15, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29329901/effects-of-orthokeratology-on-axial-length-growth-in-myopic-anisometropes
#10
Zhi Chen, Jiaqi Zhou, Xiaomei Qu, Xingtao Zhou, Feng Xue
PURPOSE: To investigate the effect of orthokeratology (ortho-k) lens wear on axial length (AL) growth in juvenile myopic anisometropes. METHODS: This retrospective study consisted of two parts. In Part One, 25 anisometropic participants (mean age, 11.2 ± 1.9 years; 11 females and 14 males) were fitted with ortho-k lenses in the more myopic eye only, and the rate of AL growth was compared between the ortho-k lens wearing eye and the untreated contralateral eye over an average period of 23...
January 10, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29315435/femtosecond-lenticule-extraction-flex-for-spherocylindrical-hyperopia-using-new-profiles
#11
Walter Sekundo, Anke Messerschmidt-Roth, Dan Z Reinstein, Timothy J Archer, Marcus Blum
PURPOSE: To investigate new lenticule profiles for the treatment of hyperopia by femtosecond lenticule extraction (FLEx) for spherocylindrical hyperopia using a modified laser scan sequence. METHODS: In this prospective 9-month study, 39 eyes of 22 patients with the mean age of 49 years (range: 27 to 56 years) underwent hyperopic FLEx. The mean optical zone was 6 mm (range: 5.75 to 6.75 mm) with keratometry readings and magnitude of correction adjusted mean transition zone of 2...
January 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29283140/aripiprazole-induced-transient-myopia-a-rare-entity
#12
K V Praveen Kumar, P Chiranjeevi, Md Shahid Alam
Aripiprazole is a new drug for the treatment of adults with schizophrenia. Ocular side effects of aripiprazole are very rare. Review of literature revealed few cases of aripiprazole-induced myopia. We report a rare case of aripiprazole-induced transient myopia. A 22-year-old female patient presented to the department of psychiatry with worsening of symptoms of schizophrenia and was started on aripiprazole. She presented with complaints of blurring of vision in both eyes for 1 week which started on the 3rd day following the use of aripiprazole...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29283117/refractive-lenticule-extraction-small-incision-lenticule-extraction-a-new-refractive-surgery-paradigm
#13
REVIEW
Sri Ganesh, Sheetal Brar, Raghavender Reddy Arra
Small incision lenticule extraction (SMILE), a variant of refractive lenticule extraction technology is becoming increasingly popular, as a flapless and minimally invasive form of laser vision correction (LVC) for the treatment of myopia and myopic astigmatism. This review aims at summarizing the principles, surgical technique, and clinical outcomes in terms of visual and refractive results, safety, efficacy, postoperative dry eye, aberrations, and biomechanics of SMILE and its comparison with other conventional techniques of LVC, such as laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK)...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29260192/patchy-chorioretinal-atrophy-changes-at-the-posterior-pole-after-ranibizumab-for-myopic-choroidal-neovascularization
#14
Mariacristina Parravano, Fabio Scarinci, Marta Gilardi, Lea Querques, Monica Varano, Francesco Oddone, Francesco Bandello, Giuseppe Querques
Purpose: To investigate the potential role of ranibizumab treatment on the development or enlargement of chorioretinal atrophy (CRA) at the posterior pole in eyes with myopic choroidal neovascularization (mCNV). Methods: This observational case series included patients having high myopia spherical equivalent refractive error ≥ -6.00 diopters, axial length (AxL) ≥ 26.0 mm in both eyes, and mCNV treated with ranibizumab 0.5 mg in one eye, who were retrospectively enrolled...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29260122/unusual-straatsma-syndrome-how-dogmatic-is-a-bad-prognosis
#15
Ana Vide-Escada, Helena Prior Filipe
Purpose: To show that Straatsma Syndrome can have a good outcome and to highlight an unusual presentation of this disease. Observations: A four-year-old boy presents with severe right eye amblyopia in association with high myopia, esotropia, heterochromia iridum and extensive myelinated retinal fibers involving both temporal arcades and the optic nerve head. Right eye initial visual acuity was less than 20/400 for distance and less than R6W10 for near. Left eye examination was unremarkable...
December 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29233084/a-model-for-meta-analysis-of-correlated-binary-outcomes-the-case-of-split-body-interventions
#16
Orestis Efthimiou, Dimitris Mavridis, Adriani Nikolakopoulou, Gerta Rücker, Sven Trelle, Matthias Egger, Georgia Salanti
In several areas of clinical research, it is common for trials to assign different sites of the participants' bodies to different interventions. For example, a randomized controlled trial comparing surgical techniques for correcting myopia may randomize each eye of a participant to a different operation. Under such bilateral ('split-body') interventions, the observations from each participant are correlated. It is challenging to account for these correlations at the meta-analysis level, especially when the outcome is rare...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29232338/internal-limiting-membrane-peeling-versus-inverted-flap-technique-for-treatment-of-full-thickness-macular-holes-a-comparative-study-in-a-large-series-of-patients
#17
Stanislao Rizzo, Ruggero Tartaro, Francesco Barca, Tomaso Caporossi, Daniela Bacherini, Fabrizio Giansanti
BACKGROUND: The inverted flap (IF) technique has recently been introduced in macular hole (MH) surgery. The IF technique has shown an increase of the success rate in the case of large MHs and in MHs associated with high myopia. This study reports the anatomical and functional results in a large series of patients affected by MH treated using pars plana vitrectomy and gas tamponade combined with internal limiting membrane (ILM) peeling or IF. METHODS: This is a retrospective, consecutive, nonrandomized comparative study of patients affected by idiopathic or myopic MH treated using small-gauge pars plana vitrectomy (25- or 23-gauge) between January 2011 and May 2016...
December 8, 2017: Retina
https://www.readbyqxmd.com/read/29231434/-exploration-on-three-eye-needling-technique-of-acupuncture
#18
Yu Wu, Jie Chen, Shaoling Li, Qing Yuan
The "three eye-needling" technique is one of the important component of Jin's three needling therapy, mainly used for the treatment of eye disorders such as optic atrophy, macular pigment degeneration, myopia, hyperopia, strabismus, amblyopia, diplopia, glaucoma, cataract, etc. In the paper, Jin's "three eye-needling" technique is explored, including the keys of manipulation, operation procedure and basic skills. This technique is particularly for "mind regulation", focusing on tranquilizing, observing and concentrating the mind...
March 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29227510/postoperative-corneal-asphericity-in-low-moderate-and-high-myopic-eyes-after-transepithelial-prk-using-a-new-pulse-allocation
#19
David T C Lin, Simon P Holland, Shwetabh Verma, John Hogden, Samuel Arba-Mosquera
PURPOSE: To evaluate the postoperative asphericity in low, moderate, and high myopic eyes after combined transepithelial photorefractive keratectomy and SmartSurfACE treatment (SCHWIND eye-tech-solutions GmbH, Kleinostheim, Germany). METHODS: In this retrospective case series, the outcomes of myopic SmartSurfACE were evaluated at 3 months postoperatively in 106 eyes and divided into low (less than -4.125 diopters [D]), moderate (-4.125 to -6.25 D), and high (more than -6...
December 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29215179/five-year-visual-outcome-among-people-with-correctable-visual-impairment-the-liwan-eye-study
#20
Lanhua Wang, Yanzhi Zhao, Xiaotong Han, Wenyong Huang, Guofu Huang, Mingguang He
IMPORTANCE: Longitudinal data on visual outcome of correctable visual impairments (VI) are of paramount importance for decision-maker to estimate burden and demand to treat avoidable VI. BACKGROUND: To assess the 5-year visual outcome among participants with correctable VI and to identify associated risk factors. DESIGN: Population-based longitudinal cohort study. PARTICIPANTS: Participants with correctable VI at baseline attended the 5-year follow-up visit of the Liwan Eye Study...
December 7, 2017: Clinical & Experimental Ophthalmology
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