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https://www.readbyqxmd.com/read/28539273/ion-paired-pirenzepine-loaded-micelles-as-an-ophthalmic-delivery-system-for-the-treatment-of-myopia
#1
Yanan Li, Yong Zhang, Pengmei Li, Gujie Mi, Jiasheng Tu, Linlin Sun, Thomas J Webster, Yan Shen
Myopia is one of the most common ocular disorders for which standard treatments, such as refractive surgery, often involve invasive procedures. Pirenzepine (PRZ), a muscarinic receptor antagonist, has been recognized as a promising candidate for the treatment of myopia, but possesses poor ocular bioavailability. The overall objective of this study was to prepare PRZ-sorbic acid complexes suitable to be encapsulated into micelles with high efficiency for optimal ophthalmic delivery. The results demonstrated that sorbic acid, used as the counter ion, had the most significant effects in increasing octanol-water distribution coefficient of PRZ as well as improving its corneal permeability in vitro among various counter ions tested...
May 21, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28539146/keratoconus-in-civil-aviation-pilots-in-a-report-of-six-cases
#2
Albert Rebello, Bênesson Rodrigues, Marcos Pereira
BACKGROUND: Keratoconus is a progressive noninflammatory ectatic corneal dystrophy, characterized by corneal thinning and increased curvature with central or paracentral tapered protrusion. Such changes in corneal morphology induce irregular astigmatism and myopia, resulting in visual acuity impairment. This report assesses cases in which keratoconus is not an absolute disabling condition for civil aviation pilots. METHODS: Six cases of keratoconus in active pilots are presented...
June 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28537642/orthokeratology-treatment-in-pediatric-myopia
#3
EDITORIAL
Leonard B Nelson
No abstract text is available yet for this article.
May 1, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28534320/infectious-keratitis-and-orthokeratology-lens-use-a-systematic-review
#4
REVIEW
Ka Wai Kam, Wing Yung, Gabriel Ka Hin Li, Li Jia Chen, Alvin L Young
PURPOSE: Myopia is a prevalent condition among Asians. Orthokeratology lens has gained popularity as a method of myopia control. This systematic review is to summarize the clinical profile of infectious keratitis in association with orthokeratology lens wear. METHODS: We searched in the PubMed and EMBASE for articles adopting the search strategy "(orthokeratology lens OR orthokeratology) AND (bacterial eye infection OR keratitis OR cornea ulcer OR microbial keratitis OR bacterial keratitis)", from the start date of the databases to August 23, 2016...
May 22, 2017: Infection
https://www.readbyqxmd.com/read/28525563/omics-biomarkers-in-ophthalmology
#5
Susette Lauwen, Eiko K de Jong, Dirk J Lefeber, Anneke I den Hollander
"Omics" refers to high-throughput analyses of genes, proteins, or metabolites in a biological system, and is increasingly used for ophthalmic research. These system-based approaches can unravel disease-related processes and are valuable for biomarker discovery. Furthermore, potential therapeutic targets can be identified based on omics results, and targeted follow-up experiments can be designed to gain molecular understanding of the disease and to test new therapies. Here, we review the application of omics techniques in eye diseases, focusing on age-related macular degeneration (AMD), diabetic retinopathy (DR), retinal detachment (RD), myopia, glaucoma, Fuchs' corneal dystrophy (FCD), cataract, keratoconus, and dry eyes...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28503431/a-pilot-study-of-intraocular-lens-explantation-in-69-eyes-in-chinese-patients
#6
Fang Chai, Bo Ma, Xin-Guang Yang, Juan Li, Mei-Fang Chu
AIM: To study the effects of intraocular lens (IOL) explantation and demographic characteristics. METHODS: Retrospective non-comparative case series. Clinical data recorded from patient charts included the following: demographic, preoperative and postoperative characteristics; complications; surgical methods, and changes in visual acuity. RESULTS: A total of 69 eyes in 67 Chinese patients who received IOL explants were studied. The patients' mean age at the time of explantation was 46...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28503426/expression-and-role-of-specificity-protein-1-in-the-sclera-remodeling-of-experimental-myopia-in-guinea-pigs
#7
Bo Jiang, Zhang-You Wu, Zi-Cheng Zhu, Gen-Jie Ke, Yue-Chun Wen, Si-Qin Sun
AIM: To study the expression of collagen I and transcription factor specificity protein 1 (Sp1), a transforming growth factor-β1 (TGF-β1) downstream target, and reveal the impact of the TGF-β1-Sp1 signaling pathway on collagen remodeling in myopic sclera. METHODS: Seventy-five 1-week-old guinea pigs were randomly divided into normal control, form deprivation myopia (FDM), and self-control groups. FDM was induced for different times using coverage with translucent latex balloons and FDM recovery was performed for 1wk after 4wk treatment; then, changes in refractive power and axial length were measured...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28494561/-observation-of-single-layered-inverted-internal-limiting-membrane-flap-technique-for-macular-hole-with-retinal-detachment-in-high-myopia
#8
C Z Xu, J H Wu, J W He, C Feng
Objective: To compare the outcome of pars plana vitrectomy (PPV) with a single-layered inverted internal limiting membrane (ILM) flap versus PPV with ILM peeling for the treatment of macular hole associated retinal detachment (MHRD) in high myopia. Methods: In a retrospective cohort study, PPV with 2 kinds of adjuvant surgical procedures were used in 35 moderately high myopia eyes with MHRD. These eyes were divided into 2 groups: group 1 (17 eyes) receiving PPV and ILM peeling and group 2 (18 eyes) receiving PPV with a single-layered inverted ILM flap...
May 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28494063/efficacy-and-adverse-effects-of-atropine-in-childhood-myopia-a-meta-analysis
#9
Qianwen Gong, Miroslaw Janowski, Mi Luo, Hong Wei, Bingjie Chen, Guoyuan Yang, Longqian Liu
Importance: Some uncertainty about the clinical value and dosing of atropine for the treatment of myopia in children remains. Objective: To evaluate the efficacy vs the adverse effects of various doses of atropine in the therapy for myopia in children. Data Sources: Data were obtained from PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials, from inception to April 30, 2016. The reference lists of published reviews and clinicaltrials...
May 11, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28491229/-anti-vegf-therapy-for-juxtafoveolar-choroidal-neovessels-in-people-with-high-myopia-about-a-case
#10
Moulay Omar Moustaine, Foued Dellali, Abbas El Husseini, Anne-Lise Hirsch
Choroidal neovessels are a threatening complication of high myopia, accounting for 5 to 10% of cases. They require immediate treatment because of their poor prognosis. Anti-VEGF intravitreal injections are currently a new therapeutic alternative far exceeding photodynamic therapy (PDT). Nevertheless, anti-VEGF treatment algorithm for this type of neovessels remains a matter of discussion among the authors. The purpose of this study was to highlight the difficulties in managing these neovessels and to discuss the Anti-VEGF therapeutic regimen to follow...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28486723/prospective-evaluation-of-outcomes-in-patients-undergoing-treatment-for-myopia-using-the-wavelight-refractive-suite
#11
Arthur Cummings, Daniel Durrie, Michael Gordon, Ravaughn Williams, James A Gow, Matthias Maus
PURPOSE: To evaluate outcomes in patients with myopia up to -12.00 diopters (D), with or without astigmatism up to 6.00 D, who underwent LASIK with the WaveLight Refractive Suite (Alcon Laboratories, Inc., Fort Worth, TX). METHODS: This multicenter, prospective, single-arm study evaluated patients at baseline, on the day of surgery, and 1 day and 1, 3, and 6 months postoperatively. The primary outcome was comparison of 1-month postoperative binocular uncorrected distance visual acuity (UDVA) with preoperative binocular corrected distance visual acuity (CDVA)...
May 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28481050/anisometropia-of-spherical-equivalent-and-astigmatism-among-myopes-a-23-year-follow-up-study-of-prevalence-and-changes-from-childhood-to-adulthood
#12
Olavi Pärssinen, Markku Kauppinen
PURPOSE: To study anisometropia of spherical equivalent and astigmatism from the onset of myopia at school age to adulthood. METHODS: A total of 240 myopic schoolchildren (mean age 10.9 years), with no previous spectacles, were recruited during 1983-1984 to a randomized 3-year clinical trial of bifocal treatment of myopia. Examinations with subjective cyclopedic refraction were repeated 3 years later (follow-up 1) for 238 subjects and thereafter at the mean ages of 23...
May 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28477073/-riboflavin-uva-crosslinking-in-progressive-keratoconus
#13
P Maier, T Reinhard
In patients with keratoconus, a progressive, ectatic disease of the cornea, the shape of the cornea is continuously changing leading to a reduction in visual acuity by progressive myopia and more and more (irregular) astigmatism. The symptomatic treatment consists of the prescription of glasses or special gas-permeable rigid contact lenses. Corneal tomography is generally used for diagnosis. After initial diagnosis of keratoconus, regular tomographic follow-ups should be performed. If clinically significant progression is found and confirmed by repeated measurements, riboflavin UVA collagen crosslinking should be offered to the patients...
May 5, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28447270/annual-incidences-of-visual-impairment-during-10-year-period-in-mie-prefecture-japan
#14
Kengo Ikesugi, Takako Ichio, Hideyuki Tsukitome, Mineo Kondo
PURPOSE: To determine the annual incidence of visual impairment in a Japanese population during a 10-year period. METHODS: We examined the physical disability certificates issued yearly between 2004 and 2013 in Mie prefecture, Japan. During this period 2468 visually impaired people were registered under the newly defined Act on Welfare of the Physically Disabled Persons' criteria. The age, sex distribution, and causes of visual impairment were determined from the certificates...
April 26, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28442706/nitric-oxide-no-mediates-the-inhibition-of-form-deprivation-myopia-by-atropine-in-chicks
#15
Brittany J Carr, William K Stell
Myopia is the most common childhood refractive disorder. Atropine inhibits myopia progression, but its mechanism is unknown. Here, we show that myopia-prevention by atropine requires production of nitric oxide (NO). Form-deprivation myopia (FDM) was induced in week-old chicks by diffusers over the right eye (OD); the left eye (OS) remained ungoggled. On post-goggling days 1, 3, and 5, OD received intravitreally 20 µL of phosphate-buffered saline (vehicle), or vehicle plus: NO source: L-arginine (L-Arg, 60-6,000 nmol) or sodium nitroprusside (SNP, 10-1,000 nmol); atropine (240 nmol); NO inhibitors: L-NIO or L-NMMA (6 nmol); negative controls: D-Arg (10 µmol) or D-NMMA (6 nmol); or atropine plus L-NIO, L-NMMA, or D-NMMA; OS received vehicle...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28422801/interrater-and-test-retest-reliability-of-the-beery-visual-motor-integration-in-schoolchildren
#16
Erin M Harvey, Tina K Leonard-Green, Kathleen M Mohan, Marjean Taylor Kulp, Amy L Davis, Joseph M Miller, J Daniel Twelker, Irene Campus, Leslie K Dennis
PURPOSE: To assess interrater and test-retest reliability of the 6th Edition Beery-Buktenica Developmental Test of Visual-Motor Integration (VMI) and test-retest reliability of the VMI Visual Perception Supplemental Test (VMIp) in school-age children. METHODS: Subjects were 163 Native American third- to eighth-grade students with no significant refractive error (astigmatism <1.00 D, myopia <0.75 D, hyperopia <2.50 D, anisometropia <1.50 D) or ocular abnormalities...
May 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28410723/risk-factors-predicting-steroid-induced-ocular-hypertension-after-photorefractive-keratectomy
#17
Yumna Busool, Michael Mimouni, Igor Vainer, Shmuel Levartovsky, Tzahi Sela, Gur Munzer, Igor Kaiserman
PURPOSE: To assess the risk factors contributing to steroid-induced ocular hypertension after photorefractive keratectomy (PRK). SETTING: Care Laser Centers, Tel Aviv, Israel. DESIGN: Retrospective case series. METHODS: Patients having PRK between January 2000 and December 2015 were followed for at least 3 months. Intraocular pressure (IOP) was measured using the Goldmann applanation tonometer after 1 week and after 1, 3, and 6 months...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28410280/long-term-impacts-of-orthokeratology-treatment-on-sub-basal-nerve-plexus-and-corneal-sensitivity-responses-and-their-reversibility
#18
María Nombela-Palomo, Gema Felipe-Marquez, Miguel Angel Teus, Jose Luis Hernandez-Verdejo, Amelia Nieto-Bona
PURPOSE: To examine the effects of one year of overnight orthokeratology (OK) treatment on the sub-basal nerve plexus (SBNP) and corneal sensitivity and to assess the reversibility of these effects one month after treatment interruption. METHODS: Thirty-two subjects with low-moderate myopia underwent OK treatment for one year. Fifteen non-contact lens wearers served as controls. At the time points baseline, one year of treatment, and one month after removing the OK lenses, two tests were conducted: corneal sensitivity (Cochet-Bonnet esthesiometer) and SBNP imaging by in vivo confocal microscopy...
April 13, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28407165/comparison-of-corneal-epithelial-remodeling-after-femtosecond-laser-assisted-lasik-and-small-incision-lenticule-extraction-smile
#19
Ik-Hee Ryu, Bong Jun Kim, Jong-Hyuck Lee, Sun Woong Kim
PURPOSE: To comparatively investigate changes in epithelial thickness between myopic femtosecond laser-assisted LASIK (FS-LASIK) and small incision lenticule extraction (SMILE). METHODS: This study compared the topographic epithelial thickness changes in 175 myopic eyes undergoing FS-LASIK (62 eyes) or SMILE (113 eyes). Epithelial thickness was obtained using spectral-domain optical coherence tomography before surgery and 1 and 3 months after surgery. Topographic epithelial thickness obtained by automatic algorithm and thickness variability (standard deviation over 17 imaged areas) was compared between two groups...
April 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28405488/multiple-intravitreal-ranibizumab-injections-for-persistant-choroidal-neovascularization-associated-with-presumed-ocular-histoplasmosis-syndrome
#20
Turgut Yılmaz, Seyhan Dikci, Oğuzhan Genç, Kayhan Mutlu
Presumed ocular histoplasmosis syndrome (POHS) is a clinical entity that is characterized by small, round, discrete, macular or mid peripheral atrophic (punched out) chorioretinal lesions (histo spots), peripapillary scarring, choroidal neovascularization (CNV), and the absence of anterior uveitis and vitritis. Diagnosis of this disorder is based upon characteristic clinical findings and a positive histoplasmin skin test or residence in an endemic region for Histoplasma capsulatum. There is no active systemic disease during diagnosis of POHS...
April 2017: Turkish Journal of Ophthalmology
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