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https://www.readbyqxmd.com/read/29220761/climate-change-potential-effects-on-the-hydrological-regime-of-freshwater-springs-in-the-italian-northern-apennines
#1
Federico Cervi, Francesca Petronici, Attilio Castellarin, Marco Marcaccio, Andrea Bertolini, Lisa Borgatti
In large areas of the Italian Northern Apennines, hundreds of low-yield springs provide water for drinking and industrial purposes, with short groundwater flow paths being formed within fractured sedimentary rock units. This hydrogeological setting results in spring water discharges that closely follow meteoric water recharge patterns, leading to low-flow periods concentrated in the summer/early autumn. Therefore, the springs' outflow can be very sensitive to a shortage in water recharge, as it was the case in 2003 and 2017, when a prolonged period of drought caused severe water management issues...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29209551/synchronous-occurrence-of-primary-breast-carcinoma-and-primary-colon-adenocarcinoma
#2
Gurkan Yetkin, Fevzi Celayir, Ismail Ethem Akgun, Ramazan Ucak
A 65-year-old female patient presented to the emergency clinic with abdominal pain, meteorism, and intermittent rectal bleeding. Colonoscopy was performed, and a hepatic flexure tumor was detected. Histopathological examination of biopsy revealed adenocarcinoma. Thoracoabdominal CT was performed for staging, and a spiculated contour mass was found incidentally on the left breast. Mammography and ultrasonography were performed for the cause of these findings, and suspicious lesions of malignancy were seen in the left breast...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/29193028/connectivity-in-a-karst-system-using-electrical-resistivity-tomography-and-network-theory
#3
Mariana Gómez-Nicolás, Mario Rebolledo-Vieyra, Efrain Canto-Lugo, Rodrigo Huerta-Quintanilla, Pablo Ochoa-Sandoval
The Ring of Cenotes (RC) is an alignment of numerous cenotes (sinkholes) in a semicircular form (with a radius of 100 km) located in northwestern Yucatán, México. The formation roughly coincides with a concentric ring that corresponds to a buried structure, which has been identified as the product of a meteor impact, known as the Chicxulub crater. Secondary permeability generated by the fracturing and faulting of the sedimentary sequence in the Chicxulub crater has favored the karstification process and therefore the development of underground rivers that transport water from the mainland to the sea...
November 29, 2017: Ground Water
https://www.readbyqxmd.com/read/29180618/a-transcribed-enhancer-dictates-mesendoderm-specification-in-pluripotency
#4
Michael Alexanian, Daniel Maric, Stephen P Jenkinson, Marco Mina, Clayton E Friedman, Ching-Chia Ting, Rudi Micheletti, Isabelle Plaisance, Mohamed Nemir, Damien Maison, Jasmin Kernen, Iole Pezzuto, Dominic Villeneuve, Frédéric Burdet, Mark Ibberson, Stephen L Leib, Nathan J Palpant, Nouria Hernandez, Samir Ounzain, Thierry Pedrazzini
Enhancers and long noncoding RNAs (lncRNAs) are key determinants of lineage specification during development. Here, we evaluate remodeling of the enhancer landscape and modulation of the lncRNA transcriptome during mesendoderm specification. We sort mesendodermal progenitors from differentiating embryonic stem cells (ESCs) according to Eomes expression, and find that enhancer usage is coordinated with mesendoderm-specific expression of key lineage-determining transcription factors. Many of these enhancers are associated with the expression of lncRNAs...
November 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/29166919/similar-short-term-clinical-response-to-high-dose-versus-low-dose-methotrexate-in-monotherapy-and-combination-therapy-in-patients-with-rheumatoid-arthritis
#5
Sytske Anne Bergstra, Cornelia F Allaart, Rosaline van den Berg, Arvind Chopra, Nimmisha Govind, Tom W J Huizinga, Robert B M Landewe
BACKGROUND: Aiming at rapid decrease of disease activity, there has been a trend to start with higher doses of methotrexate (MTX) in patients newly diagnosed with rheumatoid arthritis (RA), both as monotherapy and in combination with other antirheumatic drugs. We aimed to study the relationship between clinical response and MTX dose as monotherapy or combination therapy in patients with early RA. METHODS: Disease-modifying anti-rheumatic drug (DMARD)-naive patients with early RA, from a large international observational database, the METEOR database, were selected if MTX was part of their initial treatment...
November 22, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29146618/management-of-adverse-events-associated-with-cabozantinib-therapy-in-renal-cell-carcinoma
#6
REVIEW
Manuela Schmidinger, Romano Danesi
Cabozantinib was recently approved for the treatment of advanced renal cell carcinoma (RCC) after treatment with vascular endothelial growth factor (VEGF)-targeted therapy. Cabozantinib is a multikinase inhibitor targeting VEGF receptor (VEGFR) 2, mesenchymal-epithelial transition receptor, and "anexelekto" receptor tyrosine kinase. A 60-mg daily dose led to improved overall survival and progression-free survival (PFS) versus everolimus in advanced RCC patients as a second- or later-line treatment in the METEOR trial...
November 16, 2017: Oncologist
https://www.readbyqxmd.com/read/29056765/improving-photometric-calibration-of-meteor-video-camera-systems
#7
Steven Ehlert, Aaron Kingery, Robert Suggs
We present the results of new calibration tests performed by the NASA Meteoroid Environment Office (MEO) designed to help quantify and minimize systematic uncertainties in meteor photometry from video camera observations. These systematic uncertainties can be categorized by two main sources: an imperfect understanding of the linearity correction for the MEO's Watec 902H2 Ultimate video cameras and uncertainties in meteor magnitudes arising from transformations between the Watec camera's Sony EX-View HAD bandpass and the bandpasses used to determine reference star magnitudes...
September 1, 2017: Planetary and Space Science
https://www.readbyqxmd.com/read/29056366/natural-modulators-of-nonalcoholic-fatty-liver-disease-mode-of-action-analysis-and-in-silico-adme-tox-prediction
#8
Merilin Al Sharif, Petko Alov, Vessela Vitcheva, Antonia Diukendjieva, Mattia Mori, Bruno Botta, Ivanka Tsakovska, Ilza Pajeva
Nonalcoholic fatty liver disease (NAFLD) is considered to be the most common chronic liver disease. The discovery of natural product-based NAFLD modulators requires a more comprehensive study of their modes of action (MoAs). In this study we analysed available in the literature data for 26 naturally-derived compounds associated with experimental evidence for NAFLD alleviation and outlined potential biomolecular targets and a network of pharmacological MoAs for 12 compounds with the highest number of experimentally supported MoA key events, modulated by them...
December 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29044494/influence-of-seasonal-pumping-on-groundwater-sources-and-flow-system-nagaoka-plain-japan
#9
Hiroaki Abe, Changyuan Tang, Nozomu Takeuchi, Akihiko Kondoh
Intensive groundwater development in the urban area of the Nagaoka Plain, Japan, has induced changes in the pH and saturation index of calcite in groundwater. To account for these chemical changes, it is important to determine seasonal variations of recharge and the groundwater flow system in the aquifer. This study identified the sources and flow system of groundwater in this urban area by a comprehensive method using stable isotope data and a numerical groundwater model of the Nagaoka Plain. Stable isotope evidence shows that the groundwater is recharged by meteoric water originating from low-elevation areas rather than the mountains surrounding the plain...
October 17, 2017: Ground Water
https://www.readbyqxmd.com/read/28989231/controls-on-the-distribution-of-fluorescent-dissolved-organic-matter-during-an-under-ice-algal-bloom-in-the-western-arctic-ocean
#10
Wilson G Mendoza, Elliot L Weiss, Brian Schieber, B Greg Mitchell
In this study we used fluorescence excitation and emission matrix spectroscopy, hydrographic data, and a self-organizing map (SOM) analysis to assess the spatial distribution of labile and refractory fluorescent dissolved organic matter (FDOM) for the Chukchi and Beaufort Seas at the time of a massive under-ice phytoplankton bloom during early summer 2011. Biogeochemical properties were assessed through decomposition of water property classes and sample classification that employed a SOM neural network-based analysis which classified 10 clusters from 269 samples and 17 variables...
July 2017: Global Biogeochemical Cycles
https://www.readbyqxmd.com/read/28974945/spatial-autocorrelation-source-water-and-the-distribution-of-total-and-viable-microbial-abundances-within-a-crystalline-formation-to-a-depth-of-800-m
#11
E D Beaton, Marilyne Stuart, Sim Stroes-Gascoyne, Karen J King-Sharp, Ioana Gurban, Amy Festarini, Hui Q Chen
Proposed radioactive waste repositories require long residence times within deep geological settings for which we have little knowledge of local or regional subsurface dynamics that could affect the transport of hazardous species over the period of radioactive decay. Given the role of microbial processes on element speciation and transport, knowledge and understanding of local microbial ecology within geological formations being considered as host formations can aid predictions for long term safety. In this relatively unexplored environment, sampling opportunities are few and opportunistic...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28959798/reaction-kinetics-of-caoh-with-h-and-o2-and-o2caoh-with-o-implications-for-the-atmospheric-chemistry-of-meteoric-calcium
#12
Juan Carlos Gomez Martin, John M C Plane
The ablation of cosmic dust particles entering the Earth's upper atmosphere produces a layer of Ca atoms around 90 km. Here, we present a set of kinetic experiments designed to understand the nature of the Ca molecular reservoirs on the underside of the layer. CaOH was produced by laser ablation of a Ca target in the fast flow tube and detected by non-resonant laser-induced fluorescence, probing the D((2)Σ(+)) ← X((2)Σ(1)) transition at 346.9 nm. The following rate constants were measured (at 298 K): k(CaOH + H → Ca + H2O) = (1...
September 21, 2017: ACS Earth & Space Chemistry
https://www.readbyqxmd.com/read/28915768/isotopic-composition-of-bottled-water-in-saudi-arabia
#13
Watheq Al-Basheer, AbdulAziz Al-Jalal, Khaled Gasmi
The (18)O/(16)O and (2)H/(1)H ratios of 18 water brands representing the most popular bottled water brands in the Saudi market were measured using a system based on the latest advancements in tunable off-axis integrated cavity output diode laser spectroscopy (OA-ICOS) in the near-infrared spectral region. Utilizing δ(18)O and the δ(2)H values of locally produced water samples, a meteoric water line (δ(2)H = 7.84 δ(18)O + 2.11) was extracted and found to be consistent with the slope of the global meteoric water line (GMWL) and the geographic location of Saudi Arabia...
September 15, 2017: Isotopes in Environmental and Health Studies
https://www.readbyqxmd.com/read/28910852/origin-and-evolution-of-aquitard-porewater-in-the-western-coastal-plain-of-bohai-bay-china
#14
Jing Li, Xing Liang, Menggui Jin, Jilong Yang, Bin Ma, Qin Ge
High-salinity paleowater from low-permeability aquitards in coastal areas can be a major threat to groundwater resources; however, such water has rarely been studied. The chemical and isotopic compositions of porewater extracted from a 200-m-thick Quaternary sedimentary sequence in the western coastal plain of Bohai Bay, China, were analyzed to investigate the salinity origin and chemical evolution of porewater in aquitards. Porewater samples derived at depths shallower than 32 m are characterized by Cl-Na type saline water (total dissolved solids [TDS], 10...
November 2017: Ground Water
https://www.readbyqxmd.com/read/28905838/retinal-meteor
#15
Ramesh Venkatesh, Prachi Gurav, Prachi Abhishek Dave, Sankhadeep Roy
We describe a case of a 65-year old man diagnosed with retinal vasoproliferative tumour secondary to posterior uveitis. The fluorescein angiography shows an interesting meteor-like leak emanating from the tumour and rising towards the superior retina in the later frames of the angiogram. Pictorially, we call it the "Retinal Meteor" and also describe the possible mechanism for this pattern of leakage.
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28905125/biometeorological-forecasts-for-health-surveillance-and-prevention-of-meteor-tropic-effects
#16
Luis B Lecha Estela
An early method of biometeorological forecasts was developed for Cuba during the late 90s. It was based on the relationship between the daily occurrence of massive health crisis and the magnitude of the 24-h differences of partial density of oxygen in the air (PODA index). Ten years later, applying new technological facilities, a new model was developed in order to offer operational biometeorological forecast to Cuban health institutions. After a satisfactory validation process, the official bioforecast service to health institutions in Villa Clara province began on February of 2012...
September 13, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28821797/detecting-hybridization-between-sister-species-of-terebratulina-brachiopoda-cancellothyridoidea-in-the-north-atlantic-morphology-versus-molecules
#17
Carsten Lüter, Nina A Ebeling, Martin Aberhan
Investigating samples of the cancellothyridid brachiopod Terebratulina collected during the IceAGE (Me85/3) expedition of RV METEOR at the continental shelf around Iceland with both morphometrical and molecular methods, we were for the first time able to detect a hybridization event between brachiopod sister species, which are thought to have separated 60 MYA. Terebratulina retusa and T. septentrionalis can clearly be distinguished on the basis of consistent species-specific molecular signatures in both mitochondrial and nuclear markers, whereas morphometrical analyses proved to be less reliable for species determination than previously thought...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814716/lithium-enrichment-in-intracontinental-rhyolite-magmas-leads-to-li-deposits-in-caldera-basins
#18
Thomas R Benson, Matthew A Coble, James J Rytuba, Gail A Mahood
The omnipresence of lithium-ion batteries in mobile electronics, and hybrid and electric vehicles necessitates discovery of new lithium resources to meet rising demand and to diversify the global lithium supply chain. Here we demonstrate that lake sediments preserved within intracontinental rhyolitic calderas formed on eruption and weathering of lithium-enriched magmas have the potential to host large lithium clay deposits. We compare lithium concentrations of magmas formed in a variety of tectonic settings using in situ trace-element measurements of quartz-hosted melt inclusions to demonstrate that moderate to extreme lithium enrichment occurs in magmas that incorporate felsic continental crust...
August 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28730358/hydrogeochemical-characterization-and-groundwater-quality-assessment-in-intruded-coastal-brine-aquifers-laizhou-bay-china
#19
Xiaoying Zhang, Jinjie Miao, Bill X Hu, Hongwei Liu, Hanxiong Zhang, Zhen Ma
The aquifer in the coastal area of the Laizhou Bay is affected by salinization processes related to intense groundwater exploitation for brine resource and for agriculture irrigation during the last three decades. As a result, the dynamic balances among freshwater, brine, and seawater have been disturbed and the quality of groundwater has deteriorated. To fully understand the groundwater chemical distribution and evolution in the regional aquifers, hydrogeochemical and isotopic studies have been conducted based on the water samples from 102 observation wells...
September 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28715910/isotopic-fingerprints-of-the-lake-%C3%A5-abi%C3%A5-skie-ne-poland-hydrological-system-on-contemporary-carbonates-precipitated-in-the-lake
#20
Alicja Ustrzycka, Natalia Piotrowska, Alicja Bonk, Janusz Filipiak, Wojciech Tylmann
An isotopic monitoring was undertaken in 2012-2014 at Lake Żabińskie (Mazurian Lakeland, NE Poland). The aim was to identify the factors and processes controlling an isotopic composition of the lake water and to explore the mechanism responsible for recording the climatic signal in stable isotope composition of deposited carbonates. δ(18)O and δ(2)H in the precipitation, lake water column, inflows and outflow, δ(18)O and δ(13)C in the carbonate fraction of sediments trapped in the water column were recorded with monthly resolution...
July 17, 2017: Isotopes in Environmental and Health Studies
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