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https://www.readbyqxmd.com/read/28337022/model-explanation-of-the-seasonal-variation-of-%C3%AE-18-o-in-cow-bos-taurus-hair-under-temperate-conditions
#1
Guo Chen, Hans Schnyder, Karl Auerswald
Oxygen isotopes (δ(18)O) in animal and human tissues are expected to be good recorders of geographical origin and migration histories. However, seasonal variation of δ(18)O may diminish the origin information in the tissues. Here the seasonality of δ(18)O in tail hair was investigated in a domestic suckler cow (Bos taurus) that underwent different ambient conditions, physiological states, keeping and feeding during five years. A detailed mechanistic model was built to explain this variation. The measured δ(18)O in hair significantly related (p < 0...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28292905/computational-investigation-of-surface-freezing-in-a-molecular-model-of-water
#2
Amir Haji-Akbari, Pablo G Debenedetti
Water freezes in a wide variety of low-temperature environments, from meteors and atmospheric clouds to soil and biological cells. In nature, ice usually nucleates at or near interfaces, because homogenous nucleation in the bulk can only be observed at deep supercoolings. Although the effect of proximal surfaces on freezing has been extensively studied, major gaps in understanding remain regarding freezing near vapor-liquid interfaces, with earlier experimental studies being mostly inconclusive. The question of how a vapor-liquid interface affects freezing in its vicinity is therefore still a major open question in ice physics...
March 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28286925/cabozantinib-for-renal-cell-carcinoma-current-and-future-paradigms
#3
REVIEW
Ahmed Abdelaziz, Ulka Vaishampayan
Cabozantinib was approved by the FDA in April 2016 for the treatment of advanced renal cancer, pretreated with at least one prior antiangiogenic therapy. This is the first agent in the therapy of kidney cancer to show a statistically significant improvement in all three endpoints of clinical efficacy, response rate, progression free survival, and overall survival (OS), in a phase III randomized trial. The reporting of METEOR coincided with that of the Checkmate 025 study which randomized similarly eligible patients to receive nivolumab or everolimus 10 mg daily...
March 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28282079/-fibromyalgia-and-myalgic-encephalomyelitis-the-oxygen-clue
#4
Pablo Beretta
In recent years, different authors have described various musculoskeletal oxygenation alterations in patients with fibromyalgia with or without myalgic encephalomyelitis. These patients suffer from meteor-sensitivity worsening their symptoms in lower atmospheric pressure climates (decreased oxygen pressure). They also respond successfully to hyperbaric chamber treatment (increased oxygen pressure), and to coenzime Q10 intake (improved use of oxygen). Having reviewed these findings, oxygen therapy is postulated in higher concentration and pressures to relief the symptoms of fibromyalgia with or without myalgic encephalomyelitis...
July 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28212351/black-box%C3%A2-gastrointestinal%C3%A2-tract-needs%C3%A2-and%C3%A2-prospects%C3%A2-of%C3%A2-gaining%C3%A2-insights%C3%A2-of%C3%A2-fate%C3%A2-of%C3%A2-fat-%C3%A2-protein-%C3%A2-and%C3%A2-starch%C3%A2-in%C3%A2-case%C3%A2-of%C3%A2-exocrine%C3%A2-pancreatic%C3%A2-insufficiency%C3%A2-by%C3%A2-using%C3%A2-fistulated%C3%A2-pigs
#5
REVIEW
Anne Mößeler, Josef Kamphues
Exocrine pancreatic insufficiency (EPI) results in the maldigestion and malabsorption of nutrients. The digestive processes in humans and other monogastric species like rat and pig are characterized by a predominantly enzymatic digestion within the small intestine and microbial fermentation located in the hindgut. For protein, it is doctrine that only prececally absorbed amino acids can be transferred to the amino acid pool of the host, while postileal absorption of nitrogen-containing compounds occurs mainly in the form of ammonia, being a burden rather than a benefit for the organism...
February 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28147567/vegetation-effects-on-impulsive-events-in-the-acoustic-signature-of-fires
#6
Kara M Yedinak, Michael J Anderson, Kent G Apostol, Alistair M S Smith
Acoustic impulse events have long been used as diagnostics for discrete phenomena in the natural world, including the detection of meteor impacts and volcanic eruptions. Wildland fires display an array of such acoustic impulse events in the form of crackling noises. Exploratory research into the properties of these impulse events revealed information regarding the specific properties of plant material. Unique acoustic frequency bands in the upper end of the sonic spectrum correlated to changes in vegetation properties...
January 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28145486/photoacoustic-sounds-from-meteors
#7
Richard Spalding, John Tencer, William Sweatt, Benjamin Conley, Roy Hogan, Mark Boslough, GiGi Gonzales, Pavel Spurný
Concurrent sound associated with very bright meteors manifests as popping, hissing, and faint rustling sounds occurring simultaneously with the arrival of light from meteors. Numerous instances have been documented with -11 to -13 brightness. These sounds cannot be attributed to direct acoustic propagation from the upper atmosphere for which travel time would be several minutes. Concurrent sounds must be associated with some form of electromagnetic energy generated by the meteor, propagated to the vicinity of the observer, and transduced into acoustic waves...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28091552/dual-sources-of-water-overprinting-on-the-low-zircon-%C3%AE-18-o-metamorphic-country-rocks-disequilibrium-constrained-through-inverse-modelling-of-partial-reequilibration
#8
Chun-Sheng Wei, Zi-Fu Zhao
Since water is only composed of oxygen and hydrogen, δ(18)O and δ(2)H values are thus utilized to trace the origin of water(s) and quantify the water-rock interactions. While Triassic high pressure (HP) and ultrahigh pressure (UHP) metamorphic rocks across the Dabie-Sulu orogen in central-eastern China have been well documented, postcollisional magmatism driven hydrothermal systems are little known. Here we show that two sources of externally derived water interactions were revealed by oxygen isotopes for the gneissic country rocks intruded by the early Cretaceous postcollisional granitoids...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28078236/cabozantinib-in-advanced-renal-cell-carcinoma-a-meteor-impact-on-clinical-practice
#9
EDITORIAL
Paolo Grassi, Elena Verzoni, Alessia Mennitto, Giuseppe Procopio
No abstract text is available yet for this article.
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28076968/influence-of-southwest-monsoons-in-the-kashmir-valley-western-himalayas
#10
Ghulam Jeelani, Rajendrakumar D Deshpande, Rouf A Shah, Wasim Hassan
The regional climate of the Himalayas is predominated by the southwest monsoons and the western disturbances. The uplift of the Pir Panjal to its present height is believed to restrict the southwest monsoons from entering into the Kashmir Valley in the western Himalayas. In the present study, monthly precipitation samples were collected across the Kashmir Valley from June 2013 to May 2014 for δ(18)O and δ(2)H analyses to constrain the influence of southwest monsoons in the valley. Except in August, the precipitation is enriched in (18)O and (2)H from June to September and depleted from October to May...
January 12, 2017: Isotopes in Environmental and Health Studies
https://www.readbyqxmd.com/read/28043939/associations-among-meniscal-damage-meniscal-symptoms-and-knee-pain-severity
#11
L A MacFarlane, H Yang, J E Collins, A Guermazi, M H Jones, E Teeple, L Xu, E Losina, J N Katz
OBJECTIVE: Meniscal tears occur frequently in patients with knee osteoarthritis (OA). The aim of our study was to determine whether meniscal damage identified on magnetic resonance imaging (MRI) is associated with the severity of knee pain or the frequency of meniscal symptoms in patients with knee OA. METHODS: We performed a cross-sectional study using data from the Meniscal Tear in Osteoarthritis Research (MeTeOR) trial. We characterized meniscal damage hierarchically as: root tear; maceration; long and short complex or horizontal tears; and simple tears...
December 30, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28028207/holocene-carbonate-record-of-lake-kivu-reflects-the-history-of-hydrothermal-activity
#12
Jillian E Votava, Thomas C Johnson, Robert E Hecky
The sediment record of Lake Kivu reveals a complex volcanogenic and climatic Holocene history. Investigation of the inorganic carbonate record dates the onset of carbonate deposition in the mid-Holocene in Kivu's deep northern and eastern basins and identifies conditions enabling deposition. The magnitude and timing of carbonate-rich sedimentation is not so much controlled by climate but, instead, linked strongly to hydrothermal activity in the basin. Sublacustrine springs supply the vast majority of the calcium and carbonate ions required for supersaturation with respect to aragonite...
January 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27909994/cabozantinib-a-review-in-advanced-renal-cell-carcinoma
#13
Zaina T Al-Salama, Gillian M Keating
The multiple tyrosine kinase inhibitor (TKI) cabozantinib (Cabometyx™) is approved in the USA for the treatment of patients with advanced renal cell carcinoma (RCC) who have received prior antiangiogenic therapy. In the EU, cabozantinib is indicated for the treatment of advanced RCC in adults following prior vascular endothelial growth factor (VEGF)-targeted therapy. In adults with advanced or metastatic clear-cell RCC who had previously received VEGF receptor (VEGFR) TKIs, progression-free survival (PFS) and overall survival (OS) were significantly prolonged in patients who received oral cabozantinib versus oral everolimus in the pivotal METEOR trial...
December 2016: Drugs
https://www.readbyqxmd.com/read/27898247/challenges-for-the-maintenance-and-cryopreservation-of-multiple-isolates-of-model-microorganisms-an-example-using-the-marine-diatom-skeletonema-marinoi
#14
John G Day, Simon Tytor, Jenny Egardt, Monica Applegren, Cecilia Rad-Menéndez, Olga Chepurnova, Wim Vyverman, Anna Godhe
Modern genomic and metabolomic tools have provided the possibility of generating and interrogating large datasets that can provide answers to previously imponderable taxonomic, evolutionary, ecological, and physiological questions. However, the curatorial tools needed to provide and maintain the relevant biological resources on which new knowledge can be built have not kept pace with this meteoric rise in scientific capacity, its associated activity, or the huge increase in published science. The availability of biological material of guaranteed identity and quality in Biological Resource Centers is fundamental for scientific research, but it crucially depends on there being adequate preservation/maintenance methods that are capable of ensuring phenotypic, genotypic, and functional security of the biological material(s)...
November 29, 2016: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/27852905/predictors-and-outcomes-of-crossover-to-surgery-from-physical-therapy-for-meniscal-tear-and-osteoarthritis-a-randomized-trial-comparing-physical-therapy-and-surgery
#15
Jeffrey N Katz, John Wright, Kurt P Spindler, Lisa A Mandl, Clare E Safran-Norton, Emily K Reinke, Bruce A Levy, Rick W Wright, Morgan H Jones, Scott D Martin, Robert G Marx, Elena Losina
BACKGROUND: Arthroscopic partial meniscectomy (APM) combined with physical therapy (PT) have yielded pain relief similar to that provided by PT alone in randomized trials of subjects with a degenerative meniscal tear. However, many patients randomized to PT received APM before assessment of the primary outcome. We sought to identify factors associated with crossing over to APM and to compare pain relief between patients who had crossed over to APM and those who had been randomized to APM...
November 16, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27842445/cabozantinib-in-genitourinary-malignancies
#16
Tian Zhang, Se Eun Park, Cierra Hong, Daniel J George
Cabozantinib inhibits a variety of cellular receptors including VEGFR1-3, MET, AXL, RET, FLT3 and KIT. These signaling pathways have been shown to be important in genitourinary malignancies. Along its clinical development, it has shown most activity in advanced renal cell carcinoma; the METEOR study compared cabozantinib to everolimus and showed clinically and statistically significant improvements in both progression-free survival and overall survival. Herein, we review the development of cabozantinib in the genitourinary malignancies of renal cell carcinoma, prostate adenocarcinoma and urothelial carcinoma...
November 15, 2016: Future Oncology
https://www.readbyqxmd.com/read/27790616/a-comprehensive-comparison-of-the-efficacy-and-tolerability-of-racecadotril-with-other-treatments-of-acute-diarrhea-in-adults
#17
REVIEW
Wolfgang Fischbach, Viola Andresen, Marion Eberlin, Tobias Mueck, Peter Layer
Racecadotril is a guideline-recommended treatment to alleviate symptoms of acute diarrhea. A systematic review of randomized studies was performed comparing efficacy and safety of treatment with racecadotril to that with placebo or active treatments in adults. In five double-blind studies, racecadotril and placebo had comparable tolerability, but racecadotril was more effective. This was consistent across multiple efficacy parameters including duration of diarrhea, number of diarrheic stools, abdominal pain, and meteorism; it was also consistent across countries in Africa, Asia, and Europe...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27782588/a-novel-instrument-to-measure-differential-ablation-of-meteorite-samples-and-proxies-the-meteoric-ablation-simulator-masi
#18
D L Bones, J C Gómez Martín, C J Empson, J D Carrillo Sánchez, A D James, T P Conroy, J M C Plane
On entering the Earth's atmosphere, micrometeoroids partially or completely ablate, leaving behind layers of metallic atoms and ions. The relative concentration of the various metal layers is not well explained by current models of ablation. Furthermore, estimates of the total flux of cosmic dust and meteoroids entering the Earth's atmosphere vary over two orders of magnitude. To better constrain these estimates and to better model the metal layers in the mesosphere, an experimental Meteoric Ablation Simulator (MASI) has been developed...
September 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27780100/hydrochemical-characterization-of-a-mine-water-geothermal-energy-resource-in-nw-spain
#19
C Loredo, A Ordóñez, E Garcia-Ordiales, R Álvarez, N Roqueñi, P Cienfuegos, A Peña, N M Burnside
Abandoned and flooded mine networks provide underground reservoirs of mine water that can be used as a renewable geothermal energy source. A complete hydrochemical characterization of mine water is required to optimally design the geothermal installation, understand the hydraulic behavior of the water in the reservoir and prevent undesired effects such as pipe clogging via mineral precipitation. Water pumped from the Barredo-Figaredo mining reservoir (Asturias, NW Spain), which is currently exploited for geothermal use, has been studied and compared to water from a separate, nearby mountain mine and a river that receives mine water discharge and partially infiltrates into the mine workings...
January 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27778484/a-k-nearest-neighbours-approach-using-metabolism-related-fingerprints-to-improve-in-silico-metabolite-ranking
#20
Carol A Marchant, Edward M Rosser, Jonathan D Vessey
The application of biotransformation dictionaries derived by expert evaluation of known metabolic pathways represents one approach to the prediction of both phase I and phase II xenobiotic metabolites. The ranking of metabolites generated by such dictionaries has previously been achieved through the use of qualitative reasoning rules and quantitative probability values. Using the biotransformation dictionary available in the Meteor expert system, we show that metabolite over-prediction by both of these methods can be reduced by the adoption of a k-nearest neighbours methodology in which the likelihood of a predicted biotransformation is determined based on comparison of a query chemical with structurally-similar substrates with known experimental metabolic data which activate the same biotransformation...
October 25, 2016: Molecular Informatics
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