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https://www.readbyqxmd.com/read/29042859/associations-between-systemic-sclerosis-and-thyroid-diseases
#1
REVIEW
Poupak Fallahi, Ilaria Ruffilli, Dilia Giuggioli, Michele Colaci, Silvia Martina Ferrari, Alessandro Antonelli, Clodoveo Ferri
We have reviewed scientific literature about the association of systemic sclerosis (SSc) and thyroid disorders. A high incidence, and prevalence, of new cases of autoimmune thyroiditis (AT) and/or hypothyroidism have been shown in sclerodermic patients (overall in the female gender). An association among a Th1 immune-predominance, low vitamin D levels, and AT have been also shown in SSc patients. Cases of Graves' disease (GD) have been described in SSc patients, too, according with the higher prevalence of thyroid autoimmunity...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29040161/prognostic-factor-analysis-in-325-patients-with-graves-disease-treated-with-radioiodine-therapy
#2
Danrong Yang, Jianjun Xue, Wenxia Ma, Furong Liu, Yameng Fan, Jie Rong, Aimin Yang, Yan Yu
INTRODUCTION: I therapy is a choice for Graves' hyperthyroidism. Several factors that affect the success of I treatment in Graves' disease (GD) patients have been put forward. The aim of this retrospective study was to evaluate the factors influencing the success of I therapy and the occurrence of hypothyroidism after I therapy. PATIENTS AND METHODS: We reviewed 325 GD patients, who were well documented out of 779 cases, treated with I in the First Affiliated Hospital of Xi'an Jiaotong University between 2010 and 2016...
October 16, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29039351/epidemiology-risk-factors-and-prognosis-of-interferon-alpha-induced-thyroid-disorders-a-prospective-clinical-study
#3
Łukasz Obołończyk, Małgorzata Siekierska-Hellmann, Piotr Wiśniewski, Anna Lewczuk, Monika Berendt-Obołończyk, Anna Lakomy, Zofia Michalska, Danuta Radowska, Grażyna Moszkowska, Agnieszka Bianek-Bodzak, Krzysztof Sworczak
INTRODUCTION: Hepatitis C virus (HCV) infection is a worldwide problem and hepatitis, which is its natural unfavourable course, is still a challenge for hepatologist. At present, standards of treatment are changing from combined therapy with interferon alpha (IFN-α) and ribavirin to new antiviral drugs. The current classification divides interferon induced thyroid diseases (IITD) into two groups: autoimmune (Hashimoto disease, Graves disease, positive antithyroid autoantibodies in euthyroid patients) and non-autoimmune (destructive thyroiditis, non-autoimmune hypothyroidism)...
September 25, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/29039137/three-dimensional-image-in-lung-transplantation
#4
Toyofumi F Chen-Yoshikawa, Hiroshi Date
Three-dimensional computed tomography (3D-CT) technologies have been developed and, recently, high-speed and high-quality 3D-CT technologies have been introduced to the field of thoracic surgery. The purpose of this manuscript is to demonstrate the clinical application of 3D-CT technologies in lung transplantation. In Japan, because of the severe donor shortage, living-donor lobar lung transplantation (LDLLT) is essential, in addition to cadaveric lung transplantation. In LDLLT, size matching is a grave issue, since ideal size matching between donor and recipient is usually difficult because of the limited population of potential donor...
October 16, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29038858/surgical-management-of-primary-hyperparathyroidism
#5
Stephen Ryan, Danielle Courtney, Julia Moriariu, Conrad Timon
We reviewed the surgical management of primary hyperparathyroidism through a retrospective chart review of 200 parathyroidectomy procedures performed over a 12 year period. Epidemiological data and accuracy of radiological investigations used in identifying pathological parathyroid tissue location were assessed. We determined how often simultaneous removal of thyroid tissue was required during parathyroidectomy and the associated pathology. Radiology reports were screened to determine if confirmed thyroid pathology from histological specimens were referenced pre-operatively...
October 16, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29038186/incidence-duration-and-cost-of-futile-treatment-in-end-of-life-hospital-admissions-to-three-australian-public-sector-tertiary-hospitals-a-retrospective-multicentre-cohort-study
#6
Hannah E Carter, Sarah Winch, Adrian G Barnett, Malcolm Parker, Cindy Gallois, Lindy Willmott, Ben P White, Mary Anne Patton, Letitia Burridge, Gayle Salkield, Eliana Close, Leonie Callaway, Nicholas Graves
OBJECTIVES: To estimate the incidence, duration and cost of futile treatment for end-of-life hospital admissions. DESIGN: Retrospective multicentre cohort study involving a clinical audit of hospital admissions. SETTING: Three Australian public-sector tertiary hospitals. PARTICIPANTS: Adult patients who died while admitted to one of the study hospitals over a 6-month period in 2012. MAIN OUTCOME MEASURES: Incidences of futile treatment among end-of-life admissions; length of stay in both ward and intensive care settings for the duration that patients received futile treatments; health system costs associated with futile treatments; monetary valuation of bed days associated with futile treatment...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29037977/toxocariasis-in-humans-in-africa-a-systematic-review
#7
REVIEW
Felix Lötsch, Rieke Vingerling, Rene Spijker, Martin Peter Grobusch
BACKGROUND: Toxocariasis is a globally distributed zoonosis. The most important definitive hosts are dogs, whereas humans serve as paratenic hosts. Transmission to humans occurs by accidental ingestion of eggs, e.g. by consumption of contaminated fruit or vegetables. Although exposure to Toxocara is usually considered as relatively benign, it is implicated in a range of neurological, ophthalmologic and other organ-specific conditions, some of them with grave consequences. This review provides an overview on the epidemiology, presentation and risk factors of exposure to Toxocara in Africa...
October 13, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29037900/autoimmune-comorbidity-in-chronic-spontaneous-urticaria-a-systematic-review
#8
REVIEW
Pavel Kolkhir, Elena Borzova, Clive Grattan, Riccardo Asero, Dmitry Pogorelov, Marcus Maurer
Background and Objective Numerous autoimmune diseases (AIDs) have been linked to chronic spontaneous urticaria (CSU). Here, we provide the first extensive and comprehensive evaluation of the prevalence of AIDs in patients with CSU and vice versa. METHODS: A Pubmed and Google Scholar search was performed to identify studies reporting the prevalence of various AIDs in CSU and vice versa published before April 2017. RESULTS: The prevalence of individual AIDs in CSU is increased (≥1% in most studies vs ≤1% in general population)...
October 13, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29037117/sialic-acid-binding-immunoglobulin-like-lectin1-as-a-novel-predictive-biomarker-for-relapse-in-graves-disease-a-multicenter-study
#9
Koshi Hashimoto, Eijun Nishihara, Masako Matsumoto, Shunichi Matsumoto, Yasuyo Nakajima, Kazutaka Tsujimoto, Hajime Yamakage, Noriko Asahara-Satoh, Jaeduk Yoshimura Noh, Koichi Ito, Akira Miyauchi, Masatomo Mori, Masanobu Yamada, Yoshihiro Ogawa
BACKGROUND: There are currently no reliable biomarkers to predict relapse in Graves' disease (GD). In the present study, we investigated novel diagnostic biomarkers to predict the long-term remission of or relapse in GD. METHODS: A DNA microarray analysis was performed to examine gene expression in the peripheral leukocytes of a frequently relapsing patient with GD and a patient in long-term remission after the discontinuation of anti-thyroid drugs (ATDs). Based on the DNA microarray analysis, we focused on Sialic acid-binding immunoglobulin-like lectin1 (Siglec1) as a candidate novel biomarker to predict GD relapse...
October 17, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29035773/first-irish-and-tenth-case-of-small-bowel-obstruction-secondary-to-suprapubic-catheterisation-in-the-world-case-report-and-case-review-of-a-rare-complication-of-suprapubic-catheterisation
#10
Yasir Bashir, Quart Ul Ain, Muhammad Jouda, Osama Al Sahaf
INTRODUCTION: Percutaneous Suprapubic urinary bladder catheterisation (SPC) is a common procedure performed in cases of urinary retention where attempt to pass urethral catheter has failed. However, the procedure requires meticulous precision, vigilance and sound knowledge of anatomy, to avoid grave complications. We are reporting a very rare complication of Suprapubic catheterisation that is small bowel obstruction. Our case is first Irish and 10th global case of small bowel obstruction secondary to SPC...
October 10, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29035371/lncrna-mir100hg-derived-mir-100-and-mir-125b-mediate-cetuximab-resistance-via-wnt-%C3%AE-catenin-signaling
#11
Yuanyuan Lu, Xiaodi Zhao, Qi Liu, Cunxi Li, Ramona Graves-Deal, Zheng Cao, Bhuminder Singh, Jeffrey L Franklin, Jing Wang, Huaying Hu, Tianying Wei, Mingli Yang, Timothy J Yeatman, Ethan Lee, Kenyi Saito-Diaz, Scott Hinger, James G Patton, Christine H Chung, Stephan Emmrich, Jan-Henning Klusmann, Daiming Fan, Robert J Coffey
De novo and acquired resistance, which are largely attributed to genetic alterations, are barriers to effective anti-epidermal-growth-factor-receptor (EGFR) therapy. To generate cetuximab-resistant cells, we exposed cetuximab-sensitive colorectal cancer cells to cetuximab in three-dimensional culture. Using whole-exome sequencing and transcriptional profiling, we found that the long non-coding RNA MIR100HG and two embedded microRNAs, miR-100 and miR-125b, were overexpressed in the absence of known genetic events linked to cetuximab resistance...
October 16, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29034166/post-lobotomy-epilepsy-illustrated-by-the-story-of-ellinor-hamsun-the-daughter-of-the-famous-norwegian-author-knut-hamsun
#12
Mia Tuft, Karl O Nakken
In Scandinavia, at least 11.500 people were lobotomized in the period 1939-1983. Beside grave personality changes, the surgery caused epilepsy in 10-35% of the patients. Moreover, many died due to perioperative bleedings, convulsive status epilepticus or SUDEP. Most of the stories of these people are anonymous and their post-lobotomy lives are scarcely documented. If it was not for the fact that Ellinor Hamsun (1916-1987) was the daughter of the famous Nobel Prize winning Norwegian author Knut Hamsun, her lobotomy story and the subsequent iatrogenic epilepsy would probably have remained unknown...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/29033895/autoimmune-thyroid-diseases-in-patients-treated-with-alemtuzumab-for-multiple-sclerosis-an-example-of-selective-anti-tsh-receptor-immune-response
#13
REVIEW
Mario Rotondi, Martina Molteni, Paola Leporati, Valentina Capelli, Michele Marinò, Luca Chiovato
Alemtuzumab, a humanized anti-CD52 monoclonal antibody, is approved for the treatment of active relapsing-remitting multiple sclerosis (MS). Alemtuzumab induces a rapid and prolonged depletion of lymphocytes from the circulation, which results in a profound immuno-suppression status followed by an immune reconstitution phase. Secondary to reconstitution autoimmune diseases represent the most common side effect of Alemtuzumab treatment. Among them, Graves' disease (GD) is the most frequent one with an estimated prevalence ranging from 16...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29031430/leadership-line-care-rounds-application-of-the-engage-educate-execute-and-evaluate-improvement-model-for-the-prevention-of-central-line-associated-bloodstream-infections-in-children-with-cancer
#14
Angie Owings, JoBeth Graves, Sherry Johnson, Craig Gilliam, Mike Gipson, Hana Hakim
To prevent central line-associated bloodstream infections (CLABSIs), leadership line care rounds (LLCRs) used the engage, educate, execute, and evaluate improvement model to audit compliance, identify barriers and opportunities, empower patients and families, and engage leadership. Findings of excellence and improvement opportunities were communicated to unit staff and managers. LLCRs contributed to compliance with CLABSI prevention interventions.
October 11, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29029048/general-practitioners-perception-of-being-a-doctor-in-urban-vs-rural-regions-in-germany-a-focus-group-study
#15
Nadine J Pohontsch, Heike Hansen, Ingmar Schäfer, Martin Scherer
Background: Inadequate recruitment numbers for GPs in rural regions give cause for concern. Working in rural regions is less attractive among medical students because of strong associations concerning a higher workload, restriction of privacy and demands exceeding their competences. We aimed to explore perceptions of GPs working in urban versus rural regions to contrast these prejudices. Methods: We conducted nine focus groups with GPs [female = 21, male = 44] from urban and rural regions, using a semi-structured guideline...
September 23, 2017: Family Practice
https://www.readbyqxmd.com/read/29028638/malignant-hyperthermia-versus-thyroid-storm-in-a-patient-with-symptomatic-graves-disease-a-case-report
#16
Sara M Strowd, Michael B Majewski, Jennifer Asteris
Malignant hyperthermia and thyroid storm are intraoperative emergencies with overlapping symptoms but different treatment protocols. We faced this diagnostic dilemma in a 25-year-old patient with symptomatic hyperthyroidism, elevated free T3 and free T4, and low thyroid-stimulating hormone from Graves disease despite treatment with propranolol 80 mg daily and methimazole 40 mg every 8 hours. During thyroidectomy, he developed hyperthermia and hypercarbia without tachycardia. When the rate of rise of PaCO2 and temperature accelerated, we treated the patient for malignant hyperthermia, a diagnosis subsequently confirmed by genetic testing...
October 12, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29028369/toll-like-receptors-significance-ligands-signaling-pathways-and-functions-in-mammals
#17
Mallenahally Kusha Vidya, V Girish Kumar, Veerasamy Sejian, Madiajagan Bagath, Govindan Krishnan, Raghavendra Bhatta
This review attempts to cover the implication of the toll-like receptors (TLRs) in controlling immune functions with emphasis on their significance, function, regulation and expression patterns. The tripartite TLRs are type I integral transmembrane receptors that are involved in recognition and conveying of pathogens to the immune system. These paralogs are located on cell surfaces or within endosomes. The TLRs are found to be functionally involved in the recognition of self and non-self-antigens, maturation of DCs and initiation of antigen-specific adaptive immune responses as they bridge the innate and adaptive immunity...
October 13, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/29028311/radiolabeled-antibody-conjugated-manganese-oxide-nanoparticles-for-tumor-vasculature-targeted-positron-emission-tomography-and-magnetic-resonance-imaging
#18
Yonghua Zhan, Sixiang Shi, Emily B Ehlerding, Stephen A Graves, Shreya Goel, Jonathan W Engle, Jimin Liang, Jie Tian, Weibo Cai
Manganese oxide nanoparticles (Mn3O4 NPs) have attracted a great deal of attention in the field of biomedical imaging because of their ability to create an enhanced imaging signal in MRI as novel potent T1 contrast agents. In this study, we present tumor vasculature-targeted imaging in mice using Mn3O4 NPs through conjugation to the anti-CD105 antibody TRC105 and radionuclide copper-64 ((64)Cu, t1/2: 12.7 h). The Mn3O4 conjugated NPs, (64)Cu-NOTA-Mn3O4@PEG-TRC105, exhibited sufficient stability in vitro and in vivo...
October 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29026936/a-comparative-study-of-full-thickness-blepharotomy-versus-transconjunctival-eyelid-lengthening-in-the-correction-of-upper-eyelid-retraction-in-graves-orbitopathy
#19
Allan C Pieroni Gonçalves, Thiago Nogueira, Ana Carolina Arato Gonçalves, Luzia Diegues Silva, Suzana Matayoshi, Mário L R Monteiro
BACKGROUND: The study was designed to compare the outcome of full-thickness blepharotomy and transconjunctival eyelid lengthening in the correction of upper eyelid retraction (UER) in patients with Graves' orbitopathy (GO). METHODS: This is a prospective randomized interventional study. Following ophthalmic examination, determination of the ocular surface disease index (OSDI) and photography, 27 patients with UER were randomly assigned to either graded full-thickness blepharotomy (G1) or transconjunctival Müller muscle recession and graded disinsertion of the levator palpebrae superioris muscle (G2)...
October 12, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29026276/five-cases-of-childhood-onset-graves-disease-treated-with-either-surgery-or-radio-iodine-therapy
#20
Kouki Tomari, Masahiro Goto, Aya Shimada, Hiroko Yagi, Yuka Nagashima, Yukihiro Hasegawa
There are three major therapeutic options for the treatment of Graves' disease (GD): antithyroid drugs (ATDs), thyroidectomy, and radio-iodine (RAI) therapy. ATDs are the initial treatment option for children. However, some pediatric GD patients who are initially treated with ATDs require other type of treatments later on. We reviewed the medical records of childhood-onset GD cases retrospectively to report the clinical course of patients who received either surgery or RAI therapy subsequent to treatment with ATDs...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
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