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https://www.readbyqxmd.com/read/28107718/test-procedures-for-measuring-the-sub-chronic-effects-of-chemicals-on-the-freshwater-cyclopoid-eucyclops-serrulatus
#1
Marco Cifoni, Diana Maria Paola Galassi, Cecilia Faraloni, Tiziana Di Lorenzo
The purpose of this study has been to describe test procedures for measuring the (sub)chronic effects of chemicals on the freshwater cyclopoid Eucyclops serrulatus. To this end we have adapted the setting of the standard full life-cycle protocol of the marine harpacticoid A. tenuiremis to E. serrulatus. We have tested the effects of 4 different diets, two temperatures and two rearing volumes on the survival, development, reproduction and population growth rates of this species. Our results have highlighted that full life-cycle tests can be run using 2 mL-glass vials, a diet consisting of a mixture of living cells of Chlorella sorokiniana and Scenedesmus quadricauda, at either 25 °C (test duration: 42 days) or 18 °C (test duration: 51 days)...
January 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28107675/a-novel-modal-independent-ultrasonic-motor-with-dual-stator
#2
Jian Liu, Jiamei Jin, Ruinan Ji, Di Chen
In this paper, a novel modal-independent ultrasonic motor with dual stator is proposed, in order to relieve the difficulty of adjustment for coincidence of modal frequencies of a stator for multi-modal coupling type ultrasonic motor (USM). It consists of two stators (an upper stator and a lower stator) and a rotor. The stators are excited the 3rd longitudinal vibration mode, by arranging the location of rotor and two stators, the rotor can realize rotary motion by friction effect with the stators. The rotor is mounted between the maximum deformation location of the upper stator and the nodal line of the lower stator...
January 10, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28107450/systemic-t-cells-immunosuppression-of-glioma-stem-cell-derived-exosomes-is-mediated-by-monocytic-myeloid-derived-suppressor-cells
#3
Rossana Domenis, Daniela Cesselli, Barbara Toffoletto, Evgenia Bourkoula, Federica Caponnetto, Ivana Manini, Antonio Paolo Beltrami, Tamara Ius, Miran Skrap, Carla Di Loreto, Giorgia Gri
A major contributing factor to glioma development and progression is its ability to evade the immune system. Nano-meter sized vesicles, exosomes, secreted by glioma-stem cells (GSC) can act as mediators of intercellular communication to promote tumor immune escape. Here, we investigated the immunomodulatory properties of GCS-derived exosomes on different peripheral immune cell populations. Healthy donor peripheral blood mononuclear cells (PBMCs) stimulated with anti-CD3, anti-CD28 and IL-2, were treated with GSC-derived exosomes...
2017: PloS One
https://www.readbyqxmd.com/read/28107427/serine-phosphorylation-of-slp76-is-dispensable-for-t-cell-development-but-modulates-helper-t-cell-function
#4
Victor H Navas, Céline Cuche, Andres Alcover, Vincenzo Di Bartolo
The adapter protein SLP76 is a key orchestrator of T cell receptor (TCR) signal transduction. We previously identified a negative feedback loop that modulates T cell activation, involving phosphorylation of Ser376 of SLP76 by the hematopoietic progenitor kinase 1 (HPK1). However, the physiological relevance of this regulatory mechanism was still unknown. To address this question, we generated a SLP76-S376A-expressing knock-in mouse strain and investigated the effects of Ser376 mutation on T cell development and function...
2017: PloS One
https://www.readbyqxmd.com/read/28107360/correction-methyl-farnesoate-plays-a-dual-role-in-regulating-drosophila-metamorphosis
#5
Di Wen, Crisalejandra Rivera-Perez, Mohamed Abdou, Qiangqiang Jia, Qianyu He, Xi Liu, Ola Zyaan, Jingjing Xu, William G Bendena, Stephen S Tobe, Fernando G Noriega, Subba R Palli, Jian Wang, Sheng Li
[This corrects the article DOI: 10.1371/journal.pgen.1005038.].
January 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28107260/frequency-of-pregnancy-related-cancer-a-population-based-linkage-study-in-lombardy-italy
#6
Fabio Parazzini, Matteo Franchi, Alessandra Tavani, Eva Negri, Fedro Alessandro Peccatori
OBJECTIVES: The aims of this study were to estimate the occurrence of pregnancy-associated cancer overall and by site, to evaluate if the risk increases over time, and to investigate some major determinants. METHODS: This is a population-based linkage study using the regional hospital discharge forms [Scheda di Dimissione Ospedaliera (SDO)] database of Lombardy, Italy, a region with 10 million inhabitants. All resident women with a SDO reporting a birth or abortion between 2001 and 2012 were identified...
January 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28107174/biological-bases-of-human-musicality
#7
Carla Perrone-Capano, Floriana Volpicelli, Umberto di Porzio
Music is a universal language, present in all human societies. It pervades the lives of most human beings and can recall memories and feelings of the past, can exert positive effects on our mood, can be strongly evocative and ignite intense emotions, and can establish or strengthen social bonds. In this review, we summarize the research and recent progress on the origins and neural substrates of human musicality as well as the changes in brain plasticity elicited by listening or performing music. Indeed, music improves performance in a number of cognitive tasks and may have beneficial effects on diseased brains...
January 20, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28106996/evaluation-of-jatrophane-esters-from-euphorbia-spp-as-modulators-of-candida-albicans-multidrug-transporters
#8
Mélissa Esposito, Shweta Nim, Louis-Félix Nothias, Jean-François Gallard, Manpreet Kaur Rawal, Jean Costa, Fanny Roussi, Rajendra Prasad, Attilio Di Pietro, Julien Paolini, Marc Litaudon
Twenty-nine jatrophane esters (1-10, 12-30) and one lathyrane (11) diterpenoid ester isolated from Euphorbia species were evaluated for their capacity to inhibit drug-efflux activities of the primary ABC transporter CaCdr1p and the secondary MFS transporter CaMdr1p of Candida albicans, in yeast strains overexpressing the corresponding transporter. These diterpenoid esters were obtained from Euphorbia semiperfoliata (1-10), E. insularis (11), and E. dendroides (12-30) and included five new compounds, euphodendroidins P-T (26-30)...
January 20, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28106939/maximizing-output-in-rna-programmed-peptidyl-transfer-reactions
#9
Margherita Di Pisa, Anett Hauser, Oliver Seitz
A chemical reaction that is triggered by specific RNA molecules may provide opportunities for the design of artificial feedback loops. We envision a peptidyl transfer reaction, in which mRNA encoding for antiapoptotic protein would instruct the synthesis of apoptosis-inducing peptides. In this study, we tackled the RNA-programmed synthesis of a 16mer peptide derived from the Bak-BH3 protein which inhibits the antiapoptotic protein Bcl-xL. The reaction involves the transfer of a thioester-linked donor peptide fragment from one PNA conjugate onto an acceptor peptide-PNA conjugate...
January 20, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28106876/inhibition-of-innate-immune-cytosolic-surveillance-by-an-m-tuberculosis-phosphodiesterase
#10
Ruchi Jain Dey, Bappaditya Dey, Yue Zheng, Laurene S Cheung, Jie Zhou, David Sayre, Pankaj Kumar, Haidan Guo, Gyanu Lamichhane, Herman O Sintim, William R Bishai
Mycobacterium tuberculosis infection leads to cytosolic release of the bacterial cyclic dinucleotide (CDN) c-di-AMP and a host-generated CDN, cGAMP, both of which trigger type I interferon (IFN) expression in a STING-dependent manner. Here we report that M. tuberculosis has developed a mechanism to inhibit STING activation and the type I IFN response via the bacterial phosphodiesterase (PDE) CdnP, which mediates hydrolysis of both bacterial-derived c-di-AMP and host-derived cGAMP. Mutation of cdnP attenuates M...
February 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28106795/bio-based-aromatic-epoxy-monomers-for-thermoset-materials
#11
REVIEW
Feifei Ng, Guillaume Couture, Coralie Philippe, Bernard Boutevin, Sylvain Caillol
The synthesis of polymers from renewable resources is a burning issue that is actively investigated. Polyepoxide networks constitute a major class of thermosetting polymers and are extensively used as coatings, electronic materials, adhesives. Owing to their outstanding mechanical and electrical properties, chemical resistance, adhesion, and minimal shrinkage after curing, they are used in structural applications as well. Most of these thermosets are industrially manufactured from bisphenol A (BPA), a substance that was initially synthesized as a chemical estrogen...
January 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28106764/effective-alternating-direction-optimization-methods-for-sparsity-constrained-blind-image-deblurring
#12
Naixue Xiong, Ryan Wen Liu, Maohan Liang, Di Wu, Zhao Liu, Huisi Wu
Single-image blind deblurring for imaging sensors in the Internet of Things (IoT) is a challenging ill-conditioned inverse problem, which requires regularization techniques to stabilize the image restoration process. The purpose is to recover the underlying blur kernel and latent sharp image from only one blurred image. Under many degraded imaging conditions, the blur kernel could be considered not only spatially sparse, but also piecewise smooth with the support of a continuous curve. By taking advantage of the hybrid sparse properties of the blur kernel, a hybrid regularization method is proposed in this paper to robustly and accurately estimate the blur kernel...
January 18, 2017: Sensors
https://www.readbyqxmd.com/read/28106712/very-low-protein-diet-vlpd-reduces-metabolic-acidosis-in-subjects-with-chronic-kidney-disease-the-nutritional-light-signal-of-the-renal-acid-load
#13
Biagio Raffaele Di Iorio, Lucia Di Micco, Stefania Marzocco, Emanuele De Simone, Antonietta De Blasio, Maria Luisa Sirico, Luca Nardone, On Behalf Of Ubi Study Group
BACKGROUND: Metabolic acidosis is a common complication of chronic kidney disease; current guidelines recommend treatment with alkali if bicarbonate levels are lower than 22 mMol/L. In fact, recent studies have shown that an early administration of alkali reduces progression of CKD. The aim of the study is to evaluate the effect of fruit and vegetables to reduce the acid load in CKD. METHODS: We conducted a case-control study in 146 patients who received sodium bicarbonate...
January 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28106499/retrospective-study-of-long-term-outcome-after-brain-arteriovenous-malformation-rupture-the-rap-score
#14
Eimad Shotar, Matthieu Debarre, Nader-Antoine Sourour, Federico Di Maria, Joseph Gabrieli, Aurélien Nouet, Jacques Chiras, Vincent Degos, Frédéric Clarençon
OBJECTIVE The authors aimed to design a score for stratifying patients with brain arteriovenous malformation (BAVM) rupture, based on the likelihood of a poor long-term neurological outcome. METHODS The records of consecutive patients with BAVM hemorrhagic events who had been admitted over a period of 11 years were retrospectively reviewed. Independent predictors of a poor long-term outcome (modified Rankin Scale score ≥ 3) beyond 1 year after admission were identified. A risk stratification scale was developed and compared with the intracranial hemorrhage (ICH) score to predict poor outcome and inpatient mortality...
January 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28106422/circular-dichroism-in-multiphoton-ionization-of-resonantly-excited-he-ions
#15
M Ilchen, N Douguet, T Mazza, A J Rafipoor, C Callegari, P Finetti, O Plekan, K C Prince, A Demidovich, C Grazioli, L Avaldi, P Bolognesi, M Coreno, M Di Fraia, M Devetta, Y Ovcharenko, S Düsterer, K Ueda, K Bartschat, A N Grum-Grzhimailo, A V Bozhevolnov, A K Kazansky, N M Kabachnik, M Meyer
Intense, circularly polarized extreme-ultraviolet and near-infrared (NIR) laser pulses are combined to double ionize atomic helium via the oriented intermediate He^{+}(3p) resonance state. Applying angle-resolved electron spectroscopy, we find a large photon helicity dependence of the spectrum and the angular distribution of the electrons ejected from the resonance by NIR multiphoton absorption. The measured circular dichroism is unexpectedly found to vary strongly as a function of the NIR intensity. The experimental data are well described by theoretical modeling and possible mechanisms are discussed...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28106415/charge-dependent-directed-flow-in-cu-au-collisions-at-sqrt-s_-nn-200%C3%A2-%C3%A2-gev
#16
L Adamczyk, J K Adkins, G Agakishiev, M M Aggarwal, Z Ahammed, I Alekseev, D M Anderson, R Aoyama, A Aparin, D Arkhipkin, E C Aschenauer, M U Ashraf, A Attri, G S Averichev, X Bai, V Bairathi, R Bellwied, A Bhasin, A K Bhati, P Bhattarai, J Bielcik, J Bielcikova, L C Bland, I G Bordyuzhin, J Bouchet, J D Brandenburg, A V Brandin, I Bunzarov, J Butterworth, H Caines, M Calderón de la Barca Sánchez, J M Campbell, D Cebra, I Chakaberia, P Chaloupka, Z Chang, A Chatterjee, S Chattopadhyay, X Chen, J H Chen, J Cheng, M Cherney, W Christie, G Contin, H J Crawford, S Das, L C De Silva, R R Debbe, T G Dedovich, J Deng, A A Derevschikov, B di Ruzza, L Didenko, C Dilks, X Dong, J L Drachenberg, J E Draper, C M Du, L E Dunkelberger, J C Dunlop, L G Efimov, J Engelage, G Eppley, R Esha, S Esumi, O Evdokimov, O Eyser, R Fatemi, S Fazio, P Federic, J Fedorisin, Z Feng, P Filip, E Finch, Y Fisyak, C E Flores, L Fulek, C A Gagliardi, D Garand, F Geurts, A Gibson, M Girard, L Greiner, D Grosnick, D S Gunarathne, Y Guo, S Gupta, A Gupta, W Guryn, A I Hamad, A Hamed, R Haque, J W Harris, L He, S Heppelmann, S Heppelmann, A Hirsch, G W Hoffmann, S Horvat, B Huang, X Huang, H Z Huang, T Huang, P Huck, T J Humanic, G Igo, W W Jacobs, A Jentsch, J Jia, K Jiang, S Jowzaee, E G Judd, S Kabana, D Kalinkin, K Kang, K Kauder, H W Ke, D Keane, A Kechechyan, Z H Khan, D P Kikoła, I Kisel, A Kisiel, L Kochenda, D D Koetke, L K Kosarzewski, A F Kraishan, P Kravtsov, K Krueger, L Kumar, M A C Lamont, J M Landgraf, K D Landry, J Lauret, A Lebedev, R Lednicky, J H Lee, Y Li, C Li, W Li, X Li, X Li, T Lin, M A Lisa, Y Liu, F Liu, T Ljubicic, W J Llope, M Lomnitz, R S Longacre, X Luo, S Luo, G L Ma, R Ma, Y G Ma, L Ma, N Magdy, R Majka, A Manion, S Margetis, C Markert, H S Matis, D McDonald, S McKinzie, K Meehan, J C Mei, Z W Miller, N G Minaev, S Mioduszewski, D Mishra, B Mohanty, M M Mondal, D A Morozov, M K Mustafa, B K Nandi, Md Nasim, T K Nayak, G Nigmatkulov, T Niida, L V Nogach, T Nonaka, J Novak, S B Nurushev, G Odyniec, A Ogawa, K Oh, V A Okorokov, D Olvitt, B S Page, R Pak, Y X Pan, Y Pandit, Y Panebratsev, B Pawlik, H Pei, C Perkins, P Pile, J Pluta, K Poniatowska, J Porter, M Posik, A M Poskanzer, N K Pruthi, M Przybycien, J Putschke, H Qiu, A Quintero, S Ramachandran, R L Ray, R Reed, M J Rehbein, H G Ritter, J B Roberts, O V Rogachevskiy, J L Romero, J D Roth, L Ruan, J Rusnak, O Rusnakova, N R Sahoo, P K Sahu, I Sakrejda, S Salur, J Sandweiss, A Sarkar, J Schambach, R P Scharenberg, A M Schmah, W B Schmidke, N Schmitz, J Seger, P Seyboth, N Shah, E Shahaliev, P V Shanmuganathan, M Shao, A Sharma, M K Sharma, B Sharma, W Q Shen, S S Shi, Z Shi, Q Y Shou, E P Sichtermann, R Sikora, M Simko, S Singha, M J Skoby, D Smirnov, N Smirnov, W Solyst, L Song, P Sorensen, H M Spinka, B Srivastava, T D S Stanislaus, M Stepanov, R Stock, M Strikhanov, B Stringfellow, T Sugiura, M Sumbera, B Summa, Z Sun, Y Sun, X M Sun, B Surrow, D N Svirida, A H Tang, Z Tang, T Tarnowsky, A Tawfik, J Thäder, J H Thomas, A R Timmins, D Tlusty, T Todoroki, M Tokarev, S Trentalange, R E Tribble, P Tribedy, S K Tripathy, O D Tsai, T Ullrich, D G Underwood, I Upsal, G Van Buren, G van Nieuwenhuizen, R Varma, A N Vasiliev, R Vertesi, F Videbæk, S Vokal, S A Voloshin, A Vossen, G Wang, F Wang, J S Wang, Y Wang, H Wang, Y Wang, J C Webb, G Webb, L Wen, G D Westfall, H Wieman, S W Wissink, R Witt, Y Wu, Z G Xiao, W Xie, G Xie, K Xin, Q H Xu, Y F Xu, H Xu, Z Xu, N Xu, J Xu, C Yang, Y Yang, S Yang, Y Yang, Q Yang, Y Yang, Z Ye, Z Ye, L Yi, K Yip, I-K Yoo, N Yu, H Zbroszczyk, W Zha, J Zhang, X P Zhang, S Zhang, Y Zhang, J B Zhang, Z Zhang, S Zhang, J Zhang, J Zhao, C Zhong, L Zhou, X Zhu, Y Zoulkarneeva, M Zyzak
We present the first measurement of charge-dependent directed flow in Cu+Au collisions at sqrt[s_{NN}]=200  GeV. The results are presented as a function of the particle transverse momentum and pseudorapidity for different centralities. A finite difference between the directed flow of positive and negative charged particles is observed that qualitatively agrees with the expectations from the effects of the initial strong electric field between two colliding ions with different nuclear charges. The measured difference in directed flow is much smaller than that obtained from the parton-hadron-string-dynamics model, which suggests that most of the electric charges, i...
January 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28106372/folate-engineered-microvesicles-for-enhanced-target-and-synergistic-therapy-towards-breast-cancer
#17
Lian Zhu, Di Dong, Zi-Li Yu, Yi-Fang Zhao, Dai-Wen Pang, Zhi-Ling Zhang
As an ideal nanovector candidate, microvesicles (MVs) have been gradually utilized for packaging kinds of functional molecules for effective tumor diagnosis and therapy; however, the deficiency of their tumor targeting influenced their therapy efficacy. Through a facile phospholipid substitution strategy, MVs based drug delivery system (DDS) was apparently endowed with high tumor targeting towards breast cancer thanks to the modified folate onto the membrane of MVs, simultaneously possessed of synergistic anti-tumor effect, and in vivo tumor imaging attributed to the SA-QDs labeling...
January 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28106362/dibenzothiophene-s-s-dioxide-and-bispyridinium-based-cationic-polyfluorene-derivative-as-an-efficient-cathode-modifier-for-polymer-solar-cells
#18
Guiting Chen, Sha Liu, Jin Xu, Ruifeng He, Zhicai He, Hongbin Wu, Wei Yang, Bin Zhang, Yong Cao
A novel n-type conjugated polymer containing dibenzothiophene-S,S-dioxide (FSO), bispyridinium, and fluorene scaffolds in the backbone (PFSOPyCl) was synthesized and used in the cathode interfacial layers (CILs) of conventional polymer solar cells (PSCs). The high electron affinities and large planar structures of the FSO and bispyridinium units endowed this polymer with good energy level alignments with [6,6]-phenyl-C71 butyric acid methyl ester (PC71BM) and metal cathode, and excellent electron transport and extraction properties...
January 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28106340/gas-chromatography-with-mass-spectrometry-for-the-determination-of-phthalates-preconcentrated-by-microextraction-based-on-an-ionic-liquid
#19
Juan Ignacio Cacho, Natalia Campillo, Pilar Viñas, Manuel Hernández-Córdoba
A new procedure is proposed for the analysis of migration test solutions obtained from plastic bottles used in the packaging of edible oils. Ultrasound assisted emulsification microextraction with ionic liquids was applied for the preconcentration of six phthalate esters: dimethyl-, diethyl-, di-n-butyl, n-butylbenzyl, di-2-ethylhexyl and di-n-octylphthalate. The enriched ionic liquid was directly analyzed by gas chromatography and mass spectrometry using direct insert microvial thermal desorption. The different factors affecting the microextraction efficiency, like volume of the extracting phase (30 μL of the ionic liquid) and ultrasounds application time (25 s); and the thermal desorption step, such as desorption temperature and time, and gas flow rate, were studied...
January 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28106316/ruthenium-ii-catalyzed-meta-c-h-mono-and-difluoromethylations-by-phosphine-carboxylate-cooperation
#20
Zhixiong Ruan, Shou-Kun Zhang, Cuiju Zhu, Paul Niklas Ruth, Dietmar Stalke, Lutz Ackermann
Ruthenium(II)-catalyzed meta-selective C-H (di)fluoromethylation was accomplished by phosphine and carboxylate cooperation. The remote C-H functionalization was characterized by ample substrate scope, thereby setting the stage for meta-(di)fluoromethylation through facile C-H cleavage.
January 20, 2017: Angewandte Chemie
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