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https://www.readbyqxmd.com/read/28551945/targeting-ablation-strategies-and-electro-anatomical-systems-for-different-atrial-fibrillation-patterns
#1
Francesco Santoro, Christian H Heeger, Andreas Metzner, Natale D Brunetti, Matteo DI Biase, Karl-Heinz Kuck, Feifan Ouyang
INTRODUCTION: Catheter ablation (CA) is an established and widespread treatment option for drug refractory atrial fibrillation (AF). CA has undergone considerable improvements during the last years and several ablation strategies have been proposed for different AF patterns. EVIDENCE ACQUISITION: The main cornerstone is the electrical isolation of pulmonary veins (PVs) especially among patients with paroxysmal AF. This can be achieved mainly with the use of radiofrequency or cryo-energy...
May 25, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28551789/mitochondria-and-cardiac-hypertrophy
#2
Heberty di Tarso Fernandes Facundo, Robert Eli Brainard, Francisco Rodrigo de Lemos Caldas, Aline Maria Brito Lucas
Cardiac tissue responds to long-term hemodynamic load through initiation of a hypertrophic remodeling program. Importantly, if not counteracted this response will eventually lead to organ failure. Cardiac hypertrophic adaptations are complex, and involve multiple cellular events and the mechanisms underlying the development of cardiac hypertrophy are not well understood. Mitochondrial dysfunction has been indicated as a potential and important player in the development of cardiac hypertrophy. Additionally, substantial evidence shows that a significant portion of mitochondrial processes, necessary for normal cardiomyocyte physiology, are impacted by these hypertrophic changes...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551722/discordance-between-clinical-and-imaging-criteria-assessment-by-magnetic-resonance-imaging-of-the-foot-of-patients-with-rheumatoid-arthritis
#3
Ronaldo Garcia Rondina, Ricardo Andrade Fernandes de Mello, Valeria Valim, Rafael Burgomeister Lourenco, Elton Francisco Pavan Batista, Ronaldo de Oliveira Júnior
Evaluation of the correlation between disease activity and joint involvement was assessed by MRI in the clinically dominant foot of patients with RA. We conducted a cross-sectional descriptive study of 55 patients with RA, who were subjected to clinical evaluation and MRI assessment. Imaging of the clinically dominant foot was performed, and both the Disease Activity Score 28 (DAS28-CRP) and the Health Assessment Questionnaire-Disability Index (HAQ-DI) were measured. The majority of patients classified as in clinical remission presented some degree of inflammatory activity upon MRI evaluation...
May 27, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28551714/cue-avoidance-training-and-inhibitory-control-training-for-the-reduction-of-alcohol-consumption-a-comparison-of-effectiveness-and-investigation-of-their-mechanisms-of-action
#4
Lisa C G Di Lemma, Matt Field
RATIONALE: Both cue avoidance training (CAT) and inhibitory control training (ICT) reduce alcohol consumption in the laboratory. However, these interventions have never been directly compared and their mechanisms of action are poorly understood. OBJECTIVES: We compared the effects of both types of training on alcohol consumption and investigated if they led to theoretically predicted changes in alcohol avoidance (CAT) or alcohol inhibition (ICT) associations and changes in evaluation of alcohol cues...
May 27, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28551702/alpha-7-nicotinic-receptor-signaling-pathway-participates-in-the-neurogenesis-induced-by-chat-positive-neurons-in-the-subventricular-zone
#5
Jianping Wang, Zhengfang Lu, Xiaojie Fu, Di Zhang, Lie Yu, Nan Li, Yufeng Gao, Xianliang Liu, Chunmao Yin, Junji Ke, Liyuan Li, Mengmeng Zhai, Shiwen Wu, Jiahong Fan, Liang Lv, Junchao Liu, Xuemei Chen, Qingwu Yang, Jian Wang
Choline acetyltransferase-positive (ChAT(+)) neurons within the subventricular zone (SVZ) have been shown to promote neurogenesis after stroke in mice by secreting acetylcholine (ACh); however, the mechanisms remain unclear. Receptors known to bind ACh include the nicotinic ACh receptors (nAChRs), which are present in the SVZ and have been shown to be important for cell proliferation, differentiation, and survival. In this study, we investigated the neurogenic role of the alpha-7 nAChR (α7 nAChR) in a mouse model of middle cerebral artery occlusion (MCAO) by using α7 nAChR inhibitor methyllycaconitine...
May 27, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28551649/rare-neoplasm-mimicking-neuoroendocrine-pancreatic-tumor-a-case-report-of-solitary-fibrous-tumor-with-review-of-the-literature
#6
Francesco E D'Amico, Cesare Ruffolo, Maurizio Romano, Marina DI Domenico, Marta Sbaraglia, Angelo P Dei Tos, Tiziana Garofalo, Antonio Giordano, Iccolò Bassi, Marco Massani
BACKGROUND: Solitary fibrous tumors (SFTs) are rare biological entities described mainly in the pleura. To date, in the pancreas, only 14 cases have been reported in the English literature. CASE REPORT: A 52-year-old male was diagnosed incidentally with a suspected neuroendocrine tumor (NET) of the pancreas. He underwent pancreatic enucleation of the mass, which, at final pathology, showed spindle cell proliferation set in a collagenous background and featuring the presence of hemangiopericytoma-like blood...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551583/evaluation-of-toxic-and-genotoxic-potential-of-a-wet-gas-scrubber-effluent-obtained-from-wooden-based-biomass-furnaces-a-case-study-in-the-red-ceramic-industry-in-southern-brazil
#7
Tiago Bortolotto, Jaqueline da Silva, Alex Célio Sant'Ana, Kamila Osowski Tomazi, Reginaldo Geremias, Elídio Angioletto, Claus Tröger Pich
Red ceramic industry in southern Brazil commonly uses wood biomass as furnace fuel generating great amounts of gas emissions and ash. To avoid their impact on atmospheric environment, wet scrubbing is currently being applied in several plants. However, the water leachate formed could be potentially toxic and not managed as a common water-based effluent, since the resulting wastewater could carry many toxic compounds derived from wood pyrolysis. There is a lack of studies regarding this kind of effluent obtained specifically and strictly from wooden-based biomass furnaces...
May 25, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28551387/clinical-and-pathological-characteristic-of-metastatic-malignant-mesothelioma-initially-diagnosed-by-lymph-node-biopsy
#8
Xiang-Lan Zhu, Li-Min Gao, Fen Li, Wei-Ping Liu, Wen-Yan Zhang, Gan-Di Li, Xiu-Hui Zhang, Min Chen, Xiao-Yu Liu, Sha Zhao
BACKGROUND: It is a great challenge for pathologists to initially diagnose metastatic malignant mesothelioma (MM) by the lymph node biopsy without any history of primary MM. Because the onset of MM is hidden and the metastatic MM in lymph node is relatively uncommon. Besides, morphologic and immuohistochemistry features of MM are similar to other tumors. METHODS: In order to improve the initial diagnostic accuracy of metastatic MM from LN biopsy and to reduce or avoid the possibility of missed diagnosis or misdiagnosis, we had collected the clinical and pathological data of the metastatic MM cases in our department, and summarized the characteristics of morphological, immunohistochemical and fluorescence in situ hybridization (FISH) results...
May 13, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28551254/facile-and-sensitive-determination-of-n-nitrosamines-in-food-samples-by-high-performance-liquid-chromatography-via-combining-fluorescent-labeling-with-dispersive-liquid-liquid-microextraction
#9
Shuaimin Lu, Di Wu, Guoliang Li, Zhengxian Lv, Peiwei Gong, Lian Xia, Zhiwei Sun, Guang Chen, Xuefeng Chen, Jinmao You, Yongning Wu
The intake of N-nitrosamines (NAs) from foodstuffs is considered to be an important influence factor for several cancers. But the rapid and sensitive screening of NAs remains a challenge in the field of food safety. Inspired by that, a sensitive and rapid method was demonstrated for determination of five NAs (Nitrosopyrrolidine, Nitrosodimethylamine, Nitrosodiethylamine, Nitrosodipropylamine and Nitrosodibutylamine) using dispersive liquid-liquid microextraction (DLLME) followed by high-performance liquid chromatography with fluorescence detection (HPLC-FLD)...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28551211/phenolic-composition-antioxidant-activity-and-mineral-profile-in-two-seed-propagated-artichoke-cultivars-as-affected-by-microbial-inoculants-and-planting-time
#10
Youssef Rouphael, Giuseppe Colla, Giulia Graziani, Alberto Ritieni, Mariateresa Cardarelli, Stefania De Pascale
The aim of this study was to assess the mineral composition, antioxidant activity, total phenolics and target polyphenols of two-seed propagated artichoke cultivars 'Romolo' and 'Istar' in relation to planting time (September and October), and seed coating with a consortium of arbuscular mycorrhizal fungi and Trichoderma atroviride (coated and uncoated seeds during the second planting time). 'Romolo' was found to be richest in K(+), Ca(2+) and Mg(2+). Planting artichoke in October suppressed the antioxidant capacity (DPPH and ABTS) compared to the first planting period...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28551204/ecotoxicity-and-qsar-studies-of-glycerol-ethers-in-daphnia-magna
#11
Eduardo Perales, Jose Ignacio García, Elisabet Pires, Luis Aldea, Laura Lomba, Beatriz Giner
Glycerol is currently considered a raw, renewable material, which can be used to synthesize new glycerol derivatives that may be used as green solvents. However, these compounds must be environmentally evaluated before their use. The acute ecotoxicity of a series of mono-, di-, and trialkyl ethers synthesized from glycerol for the crustacean Daphnia magna has been studied. The EC50 values of these ethers after 24 h of exposure were determined according to the OECD 202 protocol. Their possible structural-toxicity relationships according to different alkyl substituents have been discussed after applying different QSAR models (with the DARC-PELCO approach and topological parameters)...
May 19, 2017: Chemosphere
https://www.readbyqxmd.com/read/28550819/angiosarcoma-of-the-breast-a-rare-and-dismal-complication-of-breast-surgery-associated-with-radiation
#12
Edoardo Virgilio, Mariangela Lombardi, Domenica Di Stefano, Paolo Marchetti, Marco Cavallini, Paola Addario Chieco
No abstract text is available yet for this article.
March 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28550526/fetoscopic-patch-coverage-of-experimental-myelomenigocele-using-a-two-port-access-in-fetal-sheep
#13
Lucie Guilbaud, Nathalie Roux, Stéphanie Friszer, Charles Garabedian, Ferdinand Dhombres, Bettina Bessières, Catherine Fallet-Bianco, Federico Di Rocco, Michel Zerah, Jean-Marie Jouannic
PURPOSE: This study aims to assess the feasibility and the effectiveness of a fetoscopic myelomeningocele (MMC) coverage using a sealed inert patch through a two-port access, in the sheep model. METHODS: Forty-four fetuses underwent surgical creation of a MMC defect at day 75 and were divided into four groups according to the MMC repair technique, performed at day 90. Group 1 remained untreated. Group 2 had an open surgery using suture of the defect. Groups 3 and 4 underwent defect coverage using a Gore®-polytetrafluoroethylene patch secured with surgical adhesive (Bioglue®), with an open approach (group 3) and a fetoscopic one (group 4)...
May 26, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28550448/towards-xeno-free-cultures-of-human-limbal-stem-cells-for-ocular-surface-reconstruction
#14
Zala Lužnik, Claudia Breda, Vanessa Barbaro, Stefano Ferrari, Angelo Migliorati, Enzo Di Iorio, Barbara Ferrari, Carlo Griffoni, Andrea Grassetto, Hossein Mostafa Elbadawy, Marina Bertolin
Isolated limbal epithelial stem cells (LESCs) were cultured with or without a 3T3 murine fibroblast feeder-layer (FL) in 4 different culture media on culture plates or on denuded human amniotic membrane (AM) support and fibrin gel support: (1) control medium supplemented with fetal bovine serum; (2) control medium supplemented with the synthetic serum "XerumFree™ XF205" (XF); (3) CnT-20 medium supplemented with "XerumFree™ XF205" (CnT-XF) and (4) CnT-20 medium supplemented with human AB serum (CnT-AB). The three xenogeneic media were compared to standard condition (control + FL) and parameters assessed included cell morphology, proliferative potential, number of passages, assessment of clonogenic and abortive colonies, life span, ∆Np63α expression and epithelial morphology on AM...
May 26, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28550207/atx3-atx4-and-atx5-encode-putative-h3k4-methyltransferases-and-are-critical-for-plant-development
#15
Liqun Chen, Jinhong Luo, Zhenhai Cui, Ming Xue, Li Wang, Xiaoyu Zhang, Wojtek P Pawlowski, Yan He
Methylation of lysine residues in the tail of the H3 histone is a key regulator of chromatin state and gene expression, conferred by a large family of enzymes containing an evolutionarily-conserved SET domain. One of the main types of SET domain proteins are those controlling H3K4 di- and trimethylation. The genome of Arabidopsis encodes 12 such proteins, including five ARABIDOPSIS TRITHORAX (ATX) proteins and seven ATX-Related (ATXR) proteins. Here we examined three until-now-unexplored ATX proteins, ATX3, ATX4, and ATX5...
May 26, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28550192/comparison-of-risk-prediction-scores-for-venous-thromboembolism-in-cancer-patients-a-prospective-cohort-study
#16
Nick van Es, Marcello Di Nisio, Gabriela Cesarman, Ankie Kleinjan, Hans-Martin Otten, Isabelle Mahé, Ineke T Wilts, Desirée C Twint, Ettore Porreca, Oscar Arrieta, Alain Stépanian, Kirsten Smit, Michele De Tursi, Suzanne M Bleker, Patrick M Bossuyt, Rienk Nieuwland, Pieter W Kamphuisen, Harry R Büller
In ambulatory patients with solid cancer, routine thromboprophylaxis to prevent venous thromboembolism is not recommended. Several risk prediction scores to identify cancer patients at high risk of venous thromboembolism have been proposed, but their clinical usefulness remains a matter of debate. We evaluated and directly compared the performance of the Khorana, Vienna, PROTECHT, and CONKO scores in a multinational, prospective cohort study. Patients with advanced cancer were eligible if they were planned for chemotherapy or had started chemotherapy in the previous 3 months...
May 26, 2017: Haematologica
https://www.readbyqxmd.com/read/28550186/mutations-in-the-3-untranslated-region-3-utr-of-notch1-are-associated-with-low-cd20-expression-levels-in-chronic-lymphocytic-leukemia
#17
Tamara Bittolo, Federico Pozzo, Riccardo Bomben, Tiziana D'Agaro, Vanessa Bravin, Pietro Bulian, Francesca Maria Rossi, Antonella Zucchetto, Massimo Degan, Paolo Macor, Giovanni D'Arena, Annalisa Chiarenza, Francesco Zaja, Gabriele Pozzato, Francesco Di Raimondo, Davide Rossi, Gianluca Gaidano, Giovanni Del Poeta, Valter Gattei, Michele Dal Bo
No abstract text is available yet for this article.
May 26, 2017: Haematologica
https://www.readbyqxmd.com/read/28549945/validity-of-the-rheumatoid-arthritis-impact-of-disease-raid-score-and-definition-of-cut-off-points-for-disease-activity-states-in-a-population-based-european-cohort-of-patients-with-rheumatoid-arthritis
#18
Fausto Salaffi, Marco Di Carlo, Jelena Vojinovic, Angela Tincani, Alberto Sulli, Stefano Soldano, Laura Andreoli, Francesca Dall'Ara, Ruxandra Ionescu, Katarina Simić Pašalić, Ineta Balčune, Iván Ferraz-Amaro, Malgorzata Tlustochowicz, Irena Butrimienė, Egle Punceviciene, Natalia Toroptsova, Simeon Grazio, Jadranka Morović-Vergles, Pavol Masaryk, Kati Otsa, Miguel Bernardes, Vladimira Boyadzhieva, Maurizio Cutolo
OBJECTIVES: To assess the validity of the Rheumatoid Arthritis Impact of Disease (RAID) for measuring disease activity of rheumatoid arthritis (RA), and to determine cut-off values for defining the disease activity states. METHODS: 622 RA patients from an European database have been included. Cross-validation was based on assessment of convergent and discriminant validity. Optimal cut-offs were determined against external criteria by calculating the respective 25(th) and 75(th) percentiles mean values of RAID...
May 23, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28549849/optimizing-glaucoma-screening-in-high-risk-population-design-and-1-year-findings-of-the-screening-to-prevent-stop-glaucoma-study
#19
Di Zhao, Eliseo Guallar, Prateek Gajwani, Bonnielin Swenor, John Crews, Jinan Saaddine, Lucy Mudie, Varshini Varadaraj, David S Friedman
PURPOSE: To develop, implement, and evaluate replicable community-based screening intervention designed to improve glaucoma and other eye disease detection and follow-up care in high-risk populations in the United States. We present the design of the study and describe the findings of the first year of the program. DESIGN: Prospective study to evaluate screening and follow-up. METHODS: This is an ongoing study to develop an eye screening program using trained personnel to identify individuals with ophthalmic needs, focusing on African Americans ≥50 years of age at multiple inner-city community sites in Baltimore, MD...
May 23, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28549830/high-virulence-of-methicillin-resistant-staphylococcus-aureus-st30-sccmecivc-spat019-the-dominant-community-associated-clone-in-argentina
#20
Silvina Fernandez, Camila Ledo, Santiago Lattar, Mariángeles Noto Llana, Andrea Mendoza Bertelli, Sabrina Di Gregorio, Daniel O Sordelli, Marisa I Gómez, Marta E Mollerach
Community-acquired methicillin resistant Staphylococcus aureus emerged as a worldwide health problem in the last few years. In Argentina, it is found in 70% of skin and skin structure infections in previously healthy adult patients and causes severe invasive diseases. The ST30-SCCmecIVc-spat019 clone is predominant in adult infections and has displaced the previously prevalent ST5-SCCmecIVa-spat311 clone in community settings. In the present work we compared the virulence of both clones in order to explain the displacement, and found that ST30-IVc is associated with invasive infections in adult patients from Argentina and possesses a different virulence-associated genes profile compared to ST5-IVa...
May 15, 2017: International Journal of Medical Microbiology: IJMM
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