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Yingjun Zheng, Yuping Ning, Shenglin She, Yongjie Deng, Yuwei Chen, Wenying Yi, Xiaodan Lu, Xinrui Chen, Juanhua Li, Ruikeng Li, Jie Zhang, Di Xiao, Haibo Wu, Chao Wu
AIMS: This study aimed to investigate the mediating pathway of 3 factors (psychotic symptoms, attitude toward medication, and cognitive processing speed) on the effect of insight on personal-social functioning in patients with schizophrenia. METHODS: Chinese inpatients with schizophrenia (n = 168; mean age 18 ± 50 years) diagnosed according to the DSM-IV were randomly assigned to treatment with antipsychotic medication alone or combined treatment. Positive and Negative Syndrome Scale (PANSS), Drug Attitude Inventory (DAI), Assessment of Insight (SAI), and Social-Personal Performance Scale (PSPS) scores were evaluated at baseline and at 3, 6, and 12 months...
February 14, 2018: Psychopathology
A Calcagno, C Pinnetti, A De Nicolò, E Scarvaglieri, M Gisslen, M Tempestilli, A D'Avolio A, V Fedele, G Di Perri, A Antinori, S Bonora
Abacavir is a widely used nucleotide reverse transcriptase inhibitor whose cerebrospinal fluid (CSF) exposure has been previously assessed in twice-daily recipients. We studied abacavir CSF concentrations in 61 and 9 HIV-positive once-daily and twice-daily abacavir intakers. Patients on once-daily abacavir had higher plasma and CSF concentrations (96 vs. 22 ng/mL, p=0.038 and 123 vs. 49 ng/mL, p=0.038) but similar CSF-to-plasma ratios (0.8 vs. 0.5, p=0.500). CSF abacavir concentrations were adequate in once-daily receiving patients...
February 14, 2018: British Journal of Clinical Pharmacology
Adnan Šišić, Jelena Baćanović-Šišić, Petr Karlovsky, Raphaël Wittwer, Florian Walder, Enio Campiglia, Emanuele Radicetti, Hanna Friberg, Jörg Peter Baresel, Maria R Finckh
Leguminous cover crop and living mulch species show not only great potential for providing multiple beneficial services to agro-ecosystems, but may also present pathological risks for other crops in rotations through shared pathogens, especially those of the genus Fusarium. Disease severity on roots of subterranean clover, white clover, winter and summer vetch grown as cover crop and living mulch species across five European sites as well as the frequency, distribution and aggressiveness to pea of Fusarium spp...
2018: PloS One
Céline Adam, Raphaël Guérois, Anna Citarella, Laura Verardi, Florine Adolphe, Claire Béneut, Vérane Sommermeyer, Claire Ramus, Jérôme Govin, Yohann Couté, Valérie Borde
Histone H3K4 methylation is a feature of meiotic recombination hotspots shared by many organisms including plants and mammals. Meiotic recombination is initiated by programmed double-strand break (DSB) formation that in budding yeast takes place in gene promoters and is promoted by histone H3K4 di/trimethylation. This histone modification is recognized by Spp1, a PHD-finger containing protein that belongs to the conserved histone H3K4 methyltransferase Set1 complex. During meiosis, Spp1 binds H3K4me3 and interacts with a DSB protein, Mer2, to promote DSB formation close to gene promoters...
February 14, 2018: PLoS Genetics
Di Mo, Ran Wang, Ning Wang, Tian Lv, Ke-Shu Zhang, Yi-Rong Wu
We present a three-dimensional (3D) imaging method for long-range spinning targets. This method acquires multi-angle two-dimensional (2D) images of spinning targets by the inverse synthetic aperture lidar (ISAL) imaging technique. The 3D distribution of the scattering coefficients of a target has a mapping relationship with the series of 2D images. This mapping is analyzed, and a 3D Hough transform is used to implement inverse mapping. The parameter space of the Hough transform is the estimation of the 3D distribution of the scattering coefficients...
February 15, 2018: Optics Letters
Xinxiang Wang, Di Zhang, Sheng-You Huang
Accurate prediction of a protein's structure requires a reliable free energy function that consists of both enthalpic and entropic contributions. Although considerable progresses have been made in the calculation of {potential energies} in protein structure prediction, the computation for entropies of protein has lagged far behind, due to the challenge that estimation of entropies often requires expensive conformational sampling. In this study, we have used a knowledge-based approach to estimate the backbone conformational entropies from experimentally determined native structures...
February 14, 2018: Journal of Chemical Information and Modeling
Xue-Jian Zhang, Xiao-Wei Wang, Xiao-Di Da, Yanlin Shi, Chunli Liu, Fei Sun, Shuguang Yang, Wen-Bin Zhang
Protein-based materials call for innovative processing techniques to integrate their unique biologically enabled functions with other materials of complementary features. Herein, we report the covalent protein layer-by-layer assembly via orthogonal "Tag-Catcher" reactions as a facile and robust approach to make entirely protein-based multilayers on a variety of substrates. Programmed assembly of native telechelic proteins not only endows the materials valuable stimuli-sensitive behaviors, but also unique properties unparalleled by any synthetic counterparts...
February 14, 2018: Biomacromolecules
Qun Guo, Zheng Guo, Jianmin Shi, Wei Xiong, Haibao Zhang, Qiang Chen, Zhongwei Liu, Xinwei Wang
A new ALD process for depositing Ni3Cx thin films is reported, using bis(N,N'-di-tert-butylacetamidinato)nickel(II) and H2 plasma. The process shows a good layer-by-layer film growth behavior with a saturated film growth rate of 0.039 nm/cycle for a fairly wide process temperature window from 75 to 250 °C. Comprehensive material characterizations are performed on the Ni3Cx films deposited at 95 C with various H2 plasma pulse lengths from 5 to 12 s, and no appreciable difference is found with the change of the plasma pulse length...
February 14, 2018: ACS Applied Materials & Interfaces
Sachin S Shivatare, Vidya S Shivatare, Chung-Yi Wu, Chi-Huey Wong
We present a highly efficient way for the rapid preparation of a wide range of N-linked oligosaccharides (estimated to exceed 20,000 structures) that are commonly found on human glycoproteins. To achieve the desired structural diversity, the strategy began with the chemo-enzymatic synthesis of three kinds of oligosaccharyl fluoride modules, followed by their stepwise α-selective glycosylations at the 3-O and 6-O positions of the mannose residue of the common core trisaccharide having a crucial β-mannoside linkage...
February 5, 2018: Journal of Visualized Experiments: JoVE
Victor Babich, Matthew K Henry, Francesca Di Sole
The transport of ions through cell membranes ensures the fine control of ion content within and outside the cell that is indispensable for cell survival. These transport mechanisms are mediated by the activities of specialized transporter proteins. Specifically,pH dynamics are finely controlled by plasma membrane proton (H+) extrusion systems, such as the Na+/H+exchanger (NHE) protein family. Despite extensive efforts to study the mechanisms underlying NHE regulation, our current understanding of the biophysical and molecular properties of the NHE family is inadequate because of the limited availability of methods to effectively measure NHE activity...
February 3, 2018: Journal of Visualized Experiments: JoVE
Liu Yuhang, Zeng Jie, Han Di, Wu Kai, Yu Bowen, Chai Songgang, Chen Feng, Qiang Fu
The preparation of graphene oxide (GO) via Hummers method is usually divided into two steps: low temperature oxidation at 35 °C (Step I oxidation) and high temperature oxidation at 98 °C (Step II oxidation). However, the effect of these two steps on the exfoliation capability and chemical structure of graphite oxide (GrO) remains unclear. In this study, both the functional group content of GrO and the entire evolution of interlayer spacing were investigated during the two steps. Step I oxidation is a slowly inhomogeneous oxidation step to remove unoxidized graphite flakes...
February 14, 2018: Nanotechnology
Lijun Yang, Pan Yang, Zijun Hu, Ting Jiang, Xinchun Lai, Hong Lin, Xiaochong Zhao
The chemical doping is an effective strategy to improve the charge transport property of hole transport material (HTM). Herein, tris(2-(1H-pyrazol-1-yl)pyridine]cobalt(III) (FK102) doped 2,2,7,7-tetrakis(N, N-di-p-methoxyphenylamine)-9,9-spirobifluorene (spiro-MeOTAD) as HTM for semi-transparent cesium-containing planar perovskite solar cell (Cs0.1MA0.9PbI3) is demonstrated. Incorporating FK102 realizes efficient doping, which improves the mobility of HTM from 3.948 × 10-3 m2V-1s-1 to 2.22 × 10-2 m2V-1s-1, which is 5...
April 1, 2018: Journal of Nanoscience and Nanotechnology
Kai Zheng, Jubo Zhang, Yan Wang, Longxue Gao, Mingyu Di, Fang Yuan, Wenhui Bao, Tao Yang, Daxin Liang
In order to deal with pollution of organic dyes, magnetic Fe3O4 nanospheres (NPs) with an average diameter of 202 ± 0.5 nm were synthesized by a solvothermal method at 200 °C, and they can efficiently degrade organic dyes (methylene blue (MB), rhodamine B (RhB) and xylenol orange (XO)) aqueous solutions (20 mg/L) within 1 min. Based on this Fenton reagent, Fe3O4 NPs/biomass composite degradation column was made using sawdust as substrate, and it can efficiently degrade organic dyes continually. More importantly, the composite can be regenerated just by an ultrasonic treatment, and its degradation performance almost remains the same...
June 1, 2018: Journal of Nanoscience and Nanotechnology
M Teresa Quirós, Daniel Collado-Sanz, Elena Buñuel, Diego J Cárdenas
We have performed a systematic study of the electron structure of a series of Ni(I) and Ni(II) iodo and methyl complexes with a variety of di- and tridentate nitrogen ligands in order to study the influence of these ligands in the structure of catalytically active complexes in cross-coupling reactions. Ni(II) compounds show the expected square-planar configuration typical of complexes of d8 metals, regardless of the kind of coordinating nitrogen atom (sp2 or sp3) found in ligands derived from either trialkylamines or pyridines...
February 14, 2018: Journal of Physical Chemistry. A
Carla Guarino, Natalia Gruba, Renata Grzywa, Edyta Dyguda-Kazimierowicz, Yveline Hamon, Monika Legowska, Marcin Skoreński, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Christine Kellenberger, Dieter E Jenne, Marcin Sieńczyk, Adam Lesner, Francis Gauthier, Brice Korkmaz
The neutrophilic serine protease proteinase 3 (PR3) is involved in inflammation and immune response and thus appears as a therapeutic target for a variety of infectious and inflammatory diseases. Here we combined kinetic and molecular docking studies to increase the potency of peptidyl-diphenyl phosphonate PR3 inhibitors. Occupancy of the S1 subsite of PR3 by a nVal residue and of the S4-S5 subsites by a biotinylated Val residue as obtained in biotin-VYDnVP(O-C6H4-4-Cl)2 enhanced the second order inhibition constant kobs/[I] towards PR3 by more than ten times (kobs/[I] = 73...
February 14, 2018: Journal of Medicinal Chemistry
Maddalena Boccia, Antonella Di Vita, Liana Palermo, Giorgia Committeri, Laura Piccardi, Cecilia Guariglia
The ability of seeing with the mind's eye, the visual mental imagery, is peculiarly compromised in patients with representational neglect. Representational neglect affects the processing of the left side of a mental image and may selectively concern the ability to imagine places and/or objects. Right-brain damaged patients with representational neglect for places (RN+) lose the ability to imagine themselves within a familiar place and fail in transforming an egocentric representation of the environment into an allocentric one and vice-versa...
February 13, 2018: Brain Imaging and Behavior
Bin Yin, Shu Tang, Jiarui Sun, Xiaohui Zhang, Jiao Xu, Liangjiao Di, Zhihong Li, Yurong Hu, Endong Bao
Heat stress is exacerbated by global warming and affects human and animal health, leading to heart damage caused by imbalances in reactive oxygen species (ROS) and the antioxidant system, acid-base chemistry, electrolytes and respiratory alkalosis. Vitamin C scavenges excess ROS, and sodium bicarbonate maintains acid-base and electrolyte balance, and alleviates respiratory alkalosis. Herein, we explored the ability of vitamin C alone and in combination with equimolar sodium bicarbonate (Vitamin C-Na) to stimulate endogenous antioxidants and heat shock proteins (HSPs) to relieve heat stress in H9C2 cells...
February 13, 2018: Cell Stress & Chaperones
Alessandra Romano, Nunziatina Laura Parrinello, Calogero Vetro, Annalisa Chiarenza, Claudio Cerchione, Massimo Ippolito, Giuseppe Alberto Palumbo, Francesco Di Raimondo
Recent reports identify NLR (the ratio between absolute neutrophils counts, ANC, and absolute lymphocyte count, ALC), as predictor of progression-free survival (PFS) and overall survival (OS) in cancer patients. We retrospectively tested NLR and LMR (the ratio between absolute lymphocyte and monocyte counts) in newly diagnosed Hodgkin lymphoma (HL) patients treated upfront with a PET-2 risk-adapted strategy. NLR and LMR were calculated using records obtained from the complete blood count (CBC) from 180 newly diagnosed HL patients...
February 14, 2018: Annals of Hematology
Laura Cudillo, Raffaella Cerretti, Alessandra Picardi, Benedetta Mariotti, Gottardo De Angelis, Maria Cantonetti, Massimiliano Postorino, Eleonora Ceresoli, Giovanna De Santis, Daniela Nasso, Francesco Pisani, Enrico Scala, Fabio Di Piazza, Alessandro Lanti
In our retrospective study, 16 patients affected by advanced cutaneous T cell lymphoma (CTCL) underwent allogeneic hematopoietic stem cell transplantation (HSCT). Two patients (12.5%) were in complete remission (CR), nine (56.3%) in partial remission (PR), and five (31.2%) with active disease. The patients were transplanted from an HLA-identical (n = 7) from a mismatched (n = 1) or haploidentical (n = 1) sibling, from matched unrelated donor (n = 5), or from a single cord blood unit (n = 2). Conditioning regimen was standard myeloablative in 6 patients and at reduced intensity in 10...
February 13, 2018: Annals of Hematology
Marion E Fraunhofer, Frank Jakob, Rudi F Vogel
We wanted to identify key factors influencing the extent of β-glucan production by Lactobacillus brevis TMW 1.2112, which has been isolated from viscous, spoiled beer and which could contribute to viscosity increases of spoiled beverages via exopolysaccharide (EPS) production. In this way, we analyzed the influence of different initial pH values and carbohydrate sources on growth of and slime/β-glucan formation by this strain. In a screening of 48 carbohydrates, 14 fermentable sugars which enabled growth were identified...
February 13, 2018: Current Microbiology
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