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https://www.readbyqxmd.com/read/29245124/bisphenol-and-phthalate-concentrations-and-its-determinants-among-pregnant-women-in-a-population-based-cohort-in-the-netherlands-2004-5
#1
Elise M Philips, Vincent W V Jaddoe, Alexandros G Asimakopoulos, Kurunthachalam Kannan, Eric A P Steegers, Susana Santos, Leonardo Trasande
BACKGROUND: Exposure to bisphenols and phthalates in pregnancy may lead to adverse health effects in women themselves and their offspring. OBJECTIVE: To describe first trimester bisphenol and phthalate urine concentrations, including bisphenol and phthalate replacements, and determine nutritional, socio-demographic and lifestyle related determinants. METHODS: In a population-based prospective cohort of 1396 mothers, we measured first trimester bisphenol, phthalate and creatinine urine concentrations (samples collected in 2004-2005, median gestational age 12...
December 12, 2017: Environmental Research
https://www.readbyqxmd.com/read/29244828/involvement-of-phenoloxidase-in-browning-during-grinding-of-tenebrio-molitor-larvae
#2
Renske H Janssen, Catriona M M Lakemond, Vincenzo Fogliano, Giovanni Renzone, Andrea Scaloni, Jean-Paul Vincken
Insects are investigated as alternative protein source to meet the increasing demand for proteins in the future. Enzymatic browning occurring during grinding of insect and subsequent extraction of proteins can influence the proteins' properties, but it is unclear which enzymes are responsible for this phenomenon. This study was performed on larvae of three commonly used insect species, namely Tenebrio molitor, Alphitobius diaperinus and Hermetia illucens. Oxygen consumption measurements on protein extracts showed activity on L-tyrosine, L-3,4-di-hydroxy-phenylalanine (L-DOPA) and L-dopamine, indicating phenoloxidase as a key player in browning...
2017: PloS One
https://www.readbyqxmd.com/read/29244821/genotyping-of-mycobacterium-leprae-for-better-understanding-of-leprosy-transmission-in-fortaleza-northeastern-brazil
#3
Amanda N B Fontes, Luana N G C Lima, Rosa M S Mota, Rosa L F Almeida, Maria A Pontes, Heitor de S Gonçalves, Cristiane C Frota, Varalakshmi D Vissa, Patrick J Brennan, Ricardo J P S Guimaraes, Carl Kendall, Ligia R F S Kerr, Philip N Suffys
Leprosy is endemic in large part of Brazil with 28,761 new patients in 2015, the second largest number worldwide and reaches 9/10.000 in highly endemic regions and 2.7/10.000 in the city of Fortaleza, Ceará, Northeast Brazil. For better understanding of risk factors for leprosy transmission, we conducted an epidemiologic study supplemented by 17 locus VNTR and SNP 1-4 typing of Mycobacterium leprae in skin biopsy samples from new multibacillary (MB) patients diagnosed at a reference center in 2009 and 2010...
December 15, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29244169/circular-dichroism-spectroscopic-study-on-structural-alterations-of-histones-induced-by-post-translational-modifications-in-dna-damage-responses-lysine-9-methylation-of-h3
#4
Yudai Izumi, Koichi Matsuo, Kentaro Fujii, Akinari Yokoya, Masaki Taniguchi, Hirofumi Namatame
We report the global structural alterations in histone H3 proteins induced by lysine-9 mono-, di- and trimethylation, which are part of the critical post-translational modifications for DNA damage responses, identified using synchrotron radiation circular dichroism (CD) spectroscopy. Compared with unmodified H3, mono- and dimethylation increases the number of α-helices and decreases the numbers of β-strands, while trimethylation decreases the α-helix content and increases the β-strand content. Comparison of the secondary-structure contents of these histone H3 proteins suggests that the methylation-induced structural alterations occur at residues not only close to but also distant from the methylated sites...
December 13, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/29244118/lower-dolutegravir-plasma-concentrations-in-hiv-positive-patients-receiving-valproic-acid
#5
Annagloria Palazzo, Mattia Trunfio, Veronica Pirriatore, Maurizio Milesi, Amedeo De Nicolò, Chiara Alcantarini, Antonio D'Avolio, Stefano Bonora, Giovanni Di Perri, Andrea Calcagno
No abstract text is available yet for this article.
December 12, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29243982/endoscopic-transorbital-superior-eyelid-approach-anatomical-study-from-a-neurosurgical-perspective
#6
Alberto Di Somma, Norberto Andaluz, Luigi Maria Cavallo, Matteo de Notaris, Iacopo Dallan, Domenico Solari, Lee A Zimmer, Jeffrey T Keller, Mario Zuccarello, Alberto Prats-Galino, Paolo Cappabianca
OBJECTIVE Recent studies have proposed the superior eyelid endoscopic transorbital approach as a new minimally invasive route to access orbital lesions, mostly in otolaryngology and maxillofacial surgeries. The authors undertook this anatomical study in order to contribute a neurosurgical perspective, exploring the anterior and middle cranial fossa areas through this purely endoscopic transorbital trajectory. METHODS Anatomical dissections were performed in 10 human cadaveric heads (20 sides) using 0° and 30° endoscopes...
December 15, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29243864/elimination-fusion-self-assembly-of-a-nanometer-scale-72-nucleus-silver-cluster-caging-a-pair-of-euw10o36-9-polyoxometalates
#7
Shanshan Zhang, Haifeng Su, Zhi Wang, Xingpo Wang, Quanqin Zhao, Wenxian Chen, Chenho Tung, Di Sun, Lansun Zheng
The largest known polyoxometalate (POM)-templated silver-alkynyl cluster, [(EuW10O36)2@Ag72(tBuCC)48Cl2*4BF4] (SD/Ag20), was isolated under the solvothermal condition and structurally characterized. It was confirmed by single-crystal X-ray diffraction as a {EuW10}2-in-{Ag72} clusters-in-cluster rod-like compound. The high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) show such double anion-templated cluster is assembled from crucial single anion-templated Ag42 intermediate in the solution...
December 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29243846/aqp2-can-modulate-the-pattern-of-ca2-transients-induced-by-store-operated-ca2-entry-under-trpv4-activation
#8
Alejandro Pizzoni, Macarena López González, Gisela Di Giusto, Valeria Rivarola, Claudia Capurro, Paula Ford
There is increasing evidence indicating that aquaporins (AQPs) exert an influence in cell signaling by the interplay with the TRPV4 Ca2+ channel. Ca2+ release from intracellular stores and plasma membrane hyperpolarization due to opening of Ca2+ -activated potassium channels (KCa) are events that have been proposed to take place downstream of TRPV4 activation. A major mechanism for Ca2+ entry, activated after depletion of intracellular Ca2+ stores and driven by electrochemical forces, is the store-operated Ca2+ entry (SOCE)...
December 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29243799/parkinson-revealed-by-a-shadow-at-sunset
#9
G Di Gennaro, C Scoppetta
No abstract text is available yet for this article.
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243734/chemically-synthesized-histone-h2a-lys13-di-ubiquitination-promotes-binding-of-53bp1-to-nucleosomes
#10
Jia-Bin Li, Yun-Kun Qi, Qiao-Qiao He, Hua-Song Ai, San-Ling Liu, Jia-Xing Wang, Ji-Shen Zheng, Lei Liu, Changlin Tian
No abstract text is available yet for this article.
December 15, 2017: Cell Research
https://www.readbyqxmd.com/read/29243525/galectin-3-and-outcomes-after-anterior-wall-myocardial-infarction-treated-by-primary-percutaneous-coronary-intervention
#11
Giuseppe Di Tano, Giorgio Caretta, Renata De Maria, Luca Bettari, Marina Parolini, Sophie Testa, Salvatore Pirelli
AIM: Galectin-3 (Gal-3), a biomarker of inflammation, tissue repair and fibrogenesis, is associated to left ventricular remodeling after ST-elevated myocardial infarction (STEMI), but its relation with long-term outcomes is unclear. METHODS: In 103 consecutive patients with a first anterior STEMI treated by primary angioplasty, we assayed Gal-3 and NT-proBNP. RESULTS: Age was 65 (56-76) years, 28% were women. During 18 ± 13 months, 20 patients (19...
December 15, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29243510/health-related-quality-of-life-and-risk-of-composite-coronary-heart-disease-and-cerebrovascular-events-in-the-moli-sani-study-cohort
#12
Marialaura Bonaccio, Augusto Di Castelnuovo, Simona Costanzo, Mariarosaria Persichillo, Amalia De Curtis, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello
Background To assess the association between health-related quality of life (HRQL) and a composite outcome including incident coronary heart disease (CHD) and cerebrovascular events in a large general population-based cohort. Design Prospective analysis on 17,102 men and women (mean age 53 ± 11) free from cardiovascular disease at time of enrolment in the Moli-sani cohort (2005-2010). Methods HRQL was assessed by the 36-Item Short Form Health Survey. Hazard ratios with 95% confidence intervals (95% CIs) were calculated using multivariable Cox-proportional hazard models...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29243446/prevalence-of-dental-caries-among-schoolchildren-from-north-eastern-italian-population
#13
Andrea Dobbiani, Federico Berton, Giuseppe Perinetti, Fulvia Costantinides, Roberto DI Lenarda
OBJECTIVE: The longitudinal aspect of dental caries has not been previously reported for the Italian population. The primary object of the present study is to collect information of the prevalence of dental decay among the schoolchildren of primary school of Gradisca d'Isonzo (GO) and to analyse the tendency of caries among the students followed since the first year of school. METHODS: Subsequent examinations hold from 2011 to 2015 has been conducted by two calibrated examiners...
December 14, 2017: Minerva Stomatologica
https://www.readbyqxmd.com/read/29243387/investigation-of-cryptococcus-neoformans-magnesium-transporters-reveals-important-role-of-vacuolar-magnesium-transporter-in-regulating-fungal-virulence-factors
#14
Chen-Hao Suo, Lan-Jing Ma, Hai-Long Li, Jian-Fang Sun, Chao Li, Ming-Hui Lin, Tian-Shu Sun, Wei Du, Yan-Jian Li, Xin-Di Gao, Yang Meng, Si-Xiang Sai, Chen Ding
Cryptococcus neoformans is an important opportunistic fungal pathogen in humans. Recent studies have demonstrated that metals are critical factors for the regulation of fungal virulence in hosts. In this study, we systemically investigated the function of C. neoformans magnesium transporters in controlling the intracellular Mg balance and virulence-associated factors. We identified three Mg transporters in C. neoformans: Mgt1, Mgt2, and Mgt3. While we could not detect a Mg2+ -related growth phenotype in mgt1 and mgt3 knockout strains, a GAL7p-Mgt2 strain showed significant Mg-dependent growth defects in the presence of glucose...
December 15, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/29243303/genotoxic-and-mutagenic-properties-of-ni-and-nio-nanoparticles-investigated-by-comet-assay-%C3%AE-h2ax-staining-hprt-mutation-assay-and-toxtracker-reporter-cell-lines
#15
Emma Åkerlund, Francesca Cappellini, Sebastiano Di Bucchianico, Shafiqul Islam, Sara Skoglund, Remco Derr, Inger Odnevall Wallinder, Giel Hendriks, Hanna L Karlsson
Nickel (Ni) compounds are classified as carcinogenic to humans but the underlying mechanisms are still poorly understood. Furthermore, effects related to nanoparticles (NPs) of Ni have not been fully elucidated. The aim of this study was to investigate genotoxicity and mutagenicity of Ni and NiO NPs and compare the effect to soluble Ni from NiCl2 . We employed different models; i.e., exposure of (1) human bronchial epithelial cells (HBEC) followed by DNA strand break analysis (comet assay and γ-H2AX staining); (2) six different mouse embryonic stem (mES) reporter cell lines (ToxTracker) that are constructed to exhibit fluorescence upon the induction of various pathways of relevance for (geno)toxicity and cancer; and (3) mES cells followed by mutagenicity testing (Hprt assay)...
December 15, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29243194/kallistatin-inhibits-lymphangiogenesis-and-lymphatic-metastasis-of-gastric-cancer-by-downregulating-vegf-c-expression-and-secretion
#16
Caiqi Ma, Chuanghua Luo, Haofan Yin, Yang Zhang, Wenjun Xiong, Ting Zhang, Tianxiao Gao, Xi Wang, Di Che, Zhenzhen Fang, Lei Li, Jinye Xie, Mao Huang, Liuqing Zhu, Ping Jiang, Weiwei Qi, Ti Zhou, Zhonghan Yang, Wei Wang, Jianxing Ma, Guoquan Gao, Xia Yang
BACKGROUND: Tumor-induced lymphangiogenesis and lymphatic metastasis are predominant during the metastasis of many types of cancers. However, the endogenous inhibitors that counterbalance the lymphangiogenesis and lymphatic metastasis of tumors have not been well evaluated. Kallistatin has been recognized as an endogenous angiogenesis inhibitor. METHODS AND RESULTS: Our recent study showed for the first time that the lymphatic vessel density (LVD) was reduced in lung and stomach sections from kallistatin-overexpressing transgenic mice...
December 14, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29243159/characterization-and-identification-of-recalcitrant-organic-pollutants-rops-in-tannery-wastewater-and-its-phytotoxicity-evaluation-for-environmental-safety
#17
Ram Naresh Bharagava, Gaurav Saxena, Sikandar I Mulla, Devendra Kumar Patel
Tannery wastewater (TWW) is of serious environmental concern to pollution control authorities, because it contains highly toxic, recalcitrant organic and inorganic pollutants. The nature and characteristics of recalcitrant organic pollutants (ROPs) are not fully explored to date. Hence, the purpose of this study was to characterize and identify the ROPs present in the treated TWW. Gas chromatography-mass spectrometry data analysis showed the presence of a variety of ROPs in the treated TWW. Results unfolded that benzyl chloride, butyl octyl phthalate, 2,6-dihydroxybenzoic acid 3TMS, dibutyl phthalate, benzyl alcohol, benzyl butyl phthalate, 4-chloro-3-methyl phenol, phthalic acid, 2'6'-dihydroxyacetophenone, diisobutyl phthalate, 4-biphenyltrimethylsiloxane, di-(-2ethy hexyl)phthalate, 1,2-benzenedicarboxylic acid, dibenzyl phthalate, and nonylphenol were present in the treated TWW...
December 14, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29243133/symptomatic-cerebrospinal-fluid-hiv-1-escape-with-no-resistance-associated-mutations-following-low-level-plasma-viremia
#18
Mattia Trunfio, Sarah Beth Joseph, Valeria Ghisetti, Alessandra Romito, Caterina Martini, Jessica Cusato, Sabrina Audagnotto, Laura Pesci Kincer, Micol Ferrara, Arianna Sala, Daniele Imperiale, Giovanni Di Perri, Andrea Calcagno
The majority of neurologically symptomatic cerebrospinal fluid HIV-1 escape cases are connected with resistance-associated mutations and potentially explained by low cerebrospinal fluid antiretroviral concentrations. However, there are still significant knowledge gaps regarding the physiopathology and long-term management of neurosymptomatic viral escape. We report a case of Parkinson-like syndrome following cerebrospinal fluid HIV-1 escape in a 40-year-old female patient with an history of persistent low-level plasma viremia under treatment...
December 14, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/29243113/effect-of-ugt2b7-genotypes-on-plasma-concentration-of-valproic-acid-a-meta-analysis
#19
Ping Wang, Xiao-Qian Lin, Wen-Ke Cai, Gui-Li Xu, Meng-Di Zhou, Mei Yang, Gong-Hao He
PURPOSE: Valproic acid (VPA) is one of the most widely used antiepileptic drugs. Recently, increasing evidence suggested that polymorphisms in UGT2B7 gene were associated with VPA pharmacokinetics, but results remained controversial. Therefore, a meta-analysis was performed to derive a more precise evaluation between C802T, C161T, and G211T polymorphisms and plasma concentration of VPA. METHODS: The PubMed, EMBASE, and the Cochrane library databases were searched for eligible studies...
December 14, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29243073/clinical-quantification-of-myocardial-blood-flow-using-pet-joint-position-paper-of-the-snmmi-cardiovascular-council-and-the-asnc
#20
Venkatesh L Murthy, Timothy M Bateman, Rob S Beanlands, Daniel S Berman, Salvador Borges-Neto, Panithaya Chareonthaitawee, Manuel D Cerqueira, Robert A deKemp, E Gordon DePuey, Vasken Dilsizian, Sharmila Dorbala, Edward P Ficaro, Ernest V Garcia, Henry Gewirtz, Gary V Heller, Howard C Lewin, Saurabh Malhotra, April Mann, Terrence D Ruddy, Thomas H Schindler, Ronald G Schwartz, Piotr J Slomka, Prem Soman, Marcelo F Di Carli, Andrew Einstein, Raymond Russell, James R Corbett
No abstract text is available yet for this article.
December 14, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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