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https://www.readbyqxmd.com/read/28942469/early-versus-late-diagnosis-of-complement-factor-i-deficiency-clinical-consequences-illustrated-in-two-families-with-novel-homozygous-cfi-mutations
#1
Clara Franco-Jarava, Elena Álvarez de la Campa, Xavier Solanich, Francisco Morandeira-Rego, Virgínia Mas-Bosch, Marina García-Prat, Xavier de la Cruz, Andrea Martín-Nalda, Pere Soler-Palacín, Manuel Hernández-González, Roger Colobran
The complement system is an important effector arm of innate immunity and plays a crucial role in the defense against common pathogens. But effective defense and maintenance of homeostasis requires a careful balance between complement activation and regulation. Factor I (FI) is one of the most important regulators of the complement system. Complete FI deficiency is a rare autosomal recessive disorder typically resulting in severe, recurrent infection by encapsulated bacteria. In the present study, we describe two patients from unrelated families with complete FI deficiency diagnosed at very different ages: Patient 1 is a 60-year-old man who had experienced several severe infections (pneumonia, meningitis, sepsis) since childhood, one of which caused significant and permanent neurologic sequelae...
September 23, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28939390/exploring-parental-mentalization-in-postnatal-phase-with-a-self-report-questionnaire-prfq-factor-structure-gender-differences-and-association-with-sociodemographic-factors-the-finn-brain-birth-cohort-study
#2
Marjukka Pajulo, Mimmi Tolvanen, Nina Pyykkönen, Linnea Karlsson, Linda Mayes, Hasse Karlsson
The objective was to explore the preliminary functioning of a self-report questionnaire designed to assess parental reflective functioning (PRFQ, Luyten et al., 2009, unpublished manual) during early postnatal phase and with a large population-based sample. Parental reflective functioning (PRF) refers to parental capacity to focus on experience and feelings, within self, in the child and underlying observed reactions. Individual differences in PRF reportedly affect child attachment and socio-emotional development...
September 11, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28938791/effects-of-a-high-dose-of-microbial-phytase-and-myo-inositol-supplementation-on-growth-performance-tibia-mineralization-nutrient-digestibility-litter-moisture-content-and-foot-problems-in-broiler-chickens-fed-phosphorus-deficient-diets
#3
D Farhadi, A Karimi, Gh Sadeghi, J Rostamzadeh, M R Bedford
A total of 660 one-day-old Ross 308 broiler chicks were randomly distributed into eleven dietary treatments. Treatments included a maize-soybean meal-based diet with recommended calcium (Ca) and non-phytate phosphorus (nPP) (positive control; PC), an nPP-deficient diet (negative control; NC), NC diets supplemented with different levels of phytase (0, 500, 1,000, 2,000, 3,000, 4,000, 5,000, and 6,000 FTU/kg), a NC diet plus 0.15% myo-inositol, and a NC diet with reduced Ca level (Ca to nPP ratio same as PC)...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28934892/faecal-incontinence-a-narrative-review-of-clinic-based-management-for-the-general-gynaecologist
#4
Kathryn S Williams, Dara F Shalom, Harvey A Winkler
The objective of this article is to provide an informative and narrative review for the general Gynaecologist regarding the pathophysiology and conservative treatments available for faecal incontinence (FI). A PubMed search was performed by library staff and an author using the keywords: anal incontinence, faecal incontinence, accidental bowel leakage, outpatient clinic management of faecal incontinence and defecatory dysfunction. As the social limitations of FI can be devastating and long-term patient satisfaction rates after anal sphincteroplasty remain reportedly-low, the role of clinic-based management of FI has continued to grow...
September 22, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28934150/frailty-and-its-contributory-factors-in-older-adults-a-comparison-of-two-asian-regions-hong-kong-and-taiwan
#5
Ruby Yu, Wan-Chi Wu, Jason Leung, Susan C Hu, Jean Woo
This study aimed to compare the prevalence of frailty across three Chinese populations: Hong Kong, Taiwan-urban and Taiwan-rural. Contributing factors to disparities in frailty were also examined. Data were derived from the Osteoporotic Fractures in Men (MrOs) and Women (MsOs) (Hong Kong) Study (n = 4000) and the Taiwan Longitudinal Study on Aging (n = 2392). Frailty was defined as an index calculated from 30 multiple deficits. The ratio of the frailty index to life expectancy at birth (FI/LE) was used as an indicator of compression of morbidity...
September 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28931385/internet-use-ehealth-literacy-and-attitudes-toward-computer-internet-among-people-with-schizophrenia-spectrum-disorders-a-cross-sectional-study-in-two-distant-european-regions
#6
Christina Athanasopoulou, Maritta Välimäki, Katerina Koutra, Eliisa Löttyniemi, Antonios Bertsias, Maria Basta, Alexandros N Vgontzas, Christos Lionis
BACKGROUND: Individuals with schizophrenia spectrum disorders use the Internet for general and health-related purposes. Their ability to find, understand, and apply the health information they acquire online in order to make appropriate health decisions - known as eHealth literacy - has never been investigated. The European agenda strives to limit health inequalities and enhance mental health literacy. Nevertheless, each European member state varies in levels of Internet use and online health information-seeking...
September 20, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28931244/the-importance-of-frailty-in-the-assessment-of-influenza-vaccine-effectiveness-against-influenza-related-hospitalization-in-elderly-people
#7
Melissa K Andrew, Vivek Shinde, Lingyun Ye, Todd Hatchette, François Haguinet, Gael Dos Santos, Janet E McElhaney, Ardith Ambrose, Guy Boivin, William Bowie, Ayman Chit, May ElSherif, Karen Green, Scott Halperin, Barbara Ibarguchi, Jennie Johnstone, Kevin Katz, Joanne Langley, Jason Leblanc, Mark Loeb, Donna MacKinnon-Cameron, Anne McCarthy, Allison McGeer, Jeff Powis, David Richardson, Makeda Semret, Grant Stiver, Sylvie Trottier, Louis Valiquette, Duncan Webster, Shelly A McNeil
Background: Influenza is an important cause of morbidity and mortality among older adults. Even so, effectiveness of influenza vaccine for older adults has been reported to be lower than for younger adults, and the impact of frailty on vaccine effectiveness (VE) and outcomes is uncertain. We aimed to study VE against influenza hospitalization in older adults, focusing on the impact of frailty. Methods: We report VE of trivalent influenza vaccine (TIV) in people ≥65 years of age hospitalized during the 2011-2012 influenza season using a multicenter, prospective, test-negative case-control design...
August 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28929277/fluorescence-guided-surgery-in-the-combined-treatment-of-peritoneal-carcinomatosis-from-colorectal-cancer-preliminary-results-and-considerations
#8
Eva Lieto, Annamaria Auricchio, Francesca Cardella, Andrea Mabilia, Nicoletta Basile, Paolo Castellano, Michele Orditura, Gennaro Galizia
BACKGROUND: Indocyanine green (ICG) is a near-infrared fluorescent contrast agent, which preferentially accumulates in cancer tissue. The aim of our study was to investigate the role of fluorescence imaging (FI) with ICG (ICG-FI) for detecting peritoneal carcinomatosis (PC) from colorectal cancer (CRC). METHODS: Four CRC patients with PC scheduled for cytoreductive surgery + hyperthermic intraperitoneal chemotherapy were enrolled in this prospective study. At a median time of 50 min after 0...
September 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28929201/pelvic-floor-disorders-in-women-with-gynecologic-malignancies-a-systematic-review
#9
REVIEW
Aparna S Ramaseshan, Jessica Felton, Dana Roque, Gautam Rao, Andrea G Shipper, Tatiana V D Sanses
INTRODUCTION AND HYPOTHESIS: Pelvic floor disorders (PFDs) negatively affect quality of life in the general population, and their prevalence in gynecologic cancer survivors has not been systematically described. This study aimed to determine the prevalence of PFDs in cancer survivors. We hypothesized that the prevalence of PFDs in the gynecologic cancer population would be higher than in the general female population. METHODS: We searched PubMed (1809 to present), EMBASE (1974 to present), and the Cochrane Central Register of Controlled Trials (CENTRAL) through May 2017...
September 19, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28923175/frailty-and-usage-of-health-care-systems-results-from-the-south-australian-monitoring-and-surveillance-system-samss
#10
Elsa Dent, Eleonora Dal Grande, Kay Price, Anne W Taylor
OBJECTIVES: Little is known about frailty and its impact on health-care systems. Using large-scale population health surveillance data, this study determined the prevalence of frailty, its associated factors, and the impact it places on health care services. STUDY DESIGN: A cross-sectional snapshot of the 2013-2015 South Australian Monitoring and Surveillance System (SAMSS) database was used, focusing on individuals aged ≥65years. Frailty was assessed by the Frailty Index (FI), and classified as robust (scores≤0...
October 2017: Maturitas
https://www.readbyqxmd.com/read/28918826/islamic-medicine-in-the-middle-ages
#11
EDITORIAL
Hawa Edriss, Brittany N Rosales, Connie Nugent, Christian Conrad, Kenneth Nugent
The Islamic culture flourished between the 9th and 13th centuries. Scholars from this era made significant contributions in mathematics, science and medicine. Caliphs and physicians built hospitals that provided universal care and the foundation for medical education. Physician-scientists made significant advances in medical care, surgery and pharmacology. Notable authorities include al-Razi (865-925 CE) who wrote the Kitab al-Hawi fi al-tibb (The Comprehensive Book on Medicine), a 23-volume textbook that provided the main medical curriculum for European schools into the 14th century...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28917773/redesigning-flow-injection-after-40-years-of-development-flow-programming
#12
Jaromir Jarda Ruzicka
Automation of reagent based assays, by means of Flow Injection (FI), is based on sample processing, in which a sample flows continuously towards and through a detector for quantification of the target analyte. The Achilles heel of this methodology, the legacy of Auto Analyzer®, is continuous reagent consumption, and continuous generation of chemical waste. However, flow programming, assisted by recent advances in precise pumping, combined with the lab-on-valve technique, allows the FI manifold to be designed around a single confluence point through which sample and reagents are sequentially directed by means of a series of flow reversals...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28916963/effects-of-different-irrigation-practices-using-treated-wastewater-on-tomato-yields-quality-water-productivity-and-soil-and-fruit-mineral-contents
#13
Azize Dogan Demir, Ustun Sahin
Wastewater use in agricultural irrigation is becoming a common practice in order to meet the rising water demands in arid and semi-arid regions. The study was conducted to determine the effects of the full (FI), deficit (DI), and partial root-zone drying (PRD) irrigation practices using treated municipal wastewater (TWW) and freshwater (FW) on tomato yield, water use, fruit quality, and soil and fruit heavy metal concentrations. The TWW significantly increased marketable yield compared to the FW, as well as decreased water consumption...
September 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28916047/anorectal-malformation-hirschsprung-s-disease-a-cross-sectional-comparison-of-quality-of-life-and-bowel-function-to-healthy-controls
#14
Shireen Anne Nah, Caroline C P Ong, Seyed Ehsan Saffari, Lin Yin Ong, Te-Lu Yap, Yee Low, Anette S Jacobsen
BACKGROUND: Patients with anorectal malformation (ARM) and Hirschsprung's disease (HD) face long-term disturbance in bowel function even after definitive surgery. This study evaluates the quality of life (QOL) of patients with ARM and HD, and compares them to healthy controls using self-report questionnaires. METHODOLOGY: A prospective study was performed recruiting patients with ARM or HD from September 2013 to December 2014 who had primary surgery done in our institution at least 2 years prior to participation...
August 25, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28913923/an-ipsc-patient-specific-model-of-cfh-y402h-polymorphism-displays-characteristic-features-of-amd-and-indicates-a-beneficial-role-for-uv-light-exposure
#15
Dean Hallam, Joseph Collin, Sanja Bojic, Valeria Chichagova, Adriana Buskin, Yaobo Xu, Lucia Lafage, Elsje G Otten, George Anyfantis, Carla Mellough, Stefan Przyborski, Sameer Alharthi, Viktor Korolchuk, Andrew Lotery, Gabriele Saretzki, Martin McKibbin, Lyle Armstrong, David Steel, David Kavanagh, Majlinda Lako
Age related macular degeneration (AMD) is the most common cause of blindness, accounting for 8.7% of all blindness globally. Vision loss is caused ultimately by apoptosis of the retinal pigment epithelium (RPE) and overlying photoreceptors. Treatments are evolving for the wet form of the disease, however these do not exist for the dry form. Complement factor H (CFH) polymorphism in exon 9 (Y402H) has shown a strong association with susceptibility to AMD resulting in complement activation, recruitment of phagocytes, retinal pigment epithelium (RPE) damage and visual decline...
September 15, 2017: Stem Cells
https://www.readbyqxmd.com/read/28913664/supplementation-of-enzyme-treated-soy-protein-saves-dietary-protein-and-promotes-digestive-and-absorptive-ability-referring-to-tor-signaling-in-juvenile-fish
#16
Weiwei Xiao, Weidan Jiang, Lin Feng, Yang Liu, Pei Wu, Jun Jiang, Yongan Zhang, Xiaoqiu Zhou
This study was conducted to evaluate the effect of enzyme-treated soy protein (ETSP) supplementation in the low-protein diet on growth performance, digestive and absorptive capacities, and related signaling molecules' gene expressions in juvenile Jian carp. The results showed that percent weight gain (PWG), specific growth rate (SGR), and feed intake (FI) were decreased by reducing dietary protein from 34 to 32% (P < 0.05). Supplying low-protein diet with optimal ETSP increased previously mentioned indices of juvenile Jian carp (P < 0...
September 14, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28913300/objective-outcomes-of-closed-reduction-according-to-the-type-of-nasal-bone-fracture
#17
Chang Min Kang, Dong Gil Han
BACKGROUND: Nasal fractures have a tendency of resulting in structural or functional complications, and the results can vary according to the type of nasal bone fracture. The aim of this study was to evaluate the objective postoperative results according to the type of nasal bone fractures. METHODS: We reviewed 313 patients who had a closed reduction of nasal bone fracture. The classification of nasal bone fracture by Stranc and Robertson was used to characterize the fracture type: frontal impact group type I (FI), frontal impact group type II (FII), lateral impact group type I (LI), lateral impact group type II (LII), and comminuted fracture group (C)...
March 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28913299/correlation-between-operation-result-and-patient-satisfaction-of-nasal-bone-fracture
#18
Chang Min Kang, Dong Gil Han
BACKGROUND: Many authors have evaluated the post-reduction result of nasal bone fracture through patient satisfaction or postoperative complications. However, these results are limited because they are subjective. The aim of this study was to correlate an objective operation result with patient satisfaction and postoperative complications according to the type of nasal bone fractures. METHODS: Our study included 313 patients who had isolated nasal bone fractures and had undergone a closed reduction...
March 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28906569/prevalence-and-socio-demographic-predictors-of-food-insecurity-among-regional-and-remote-western-australian-children
#19
Stephanie Godrich, Johnny Lo, Christina Davies, Jill Darby, Amanda Devine
OBJECTIVE: Inequities can negatively impact the health outcomes of children. The aims of this study were to: i) ascertain the prevalence of food insecurity (FI) among regional and remote Western Australian (WA) children; and ii) determine which socio-demographic factors predicted child FI. METHODS: Caregiver-child dyads (n=219) completed cross-sectional surveys. Descriptive statistics and logistic regression analyses were conducted using IBM SPSS version 23. RESULTS: Overall, 20...
September 14, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28904975/rapd-profiling-dna-fragmentation-and-histomorphometric-examination-in-brains-of-wistar-rats-exposed-to-indoor-2-5%C3%A2-ghz-wi-fi-devices-radiation
#20
A O Ibitayo, O B Afolabi, A J Akinyemi, T I Ojiezeh, K O Adekoya, O O Ojewunmi
The advent of Wi-Fi connected high technology devices in executing day-to-day activities is fast evolving especially in developing countries of the world and hence the need to assess its safety among others. The present study was conducted to investigate the injurious effect of radiofrequency emissions from installed Wi-Fi devices in brains of young male rats. Animals were divided into four equal groups; group 1 served as control while groups 2, 3, and 4 were exposed to 2.5 Ghz at intervals of 30, 45, and 60 consecutive days with free access to food and water ad libitum...
2017: BioMed Research International
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