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https://www.readbyqxmd.com/read/28548711/sequential-associations-between-caregiver-talk-and-child-play-in-autism-spectrum-disorder-and-typical-development
#1
Kristen Bottema-Beutel, Caitlin Malloy, Blair P Lloyd, Rebecca Louick, Linnea Joffe-Nelson, Linda R Watson, Paul J Yoder
This study examined sequential associations between child play and caregiver talk in 98 caregiver-child dyads (Mmental age  = 14 months). Fifty dyads included a child with autism spectrum disorder (ASD). Analyses revealed sequential associations between child play and caregiver follow-in (FI) utterances (utterances related to the child's attentional focus) were stronger in the ASD as compared to the typically developing (TD) group. FI utterances were more likely to elicit functional play than caregiver-focused utterances, and more so in the ASD group...
May 26, 2017: Child Development
https://www.readbyqxmd.com/read/28544373/genetic-markers-for-inherited-thrombophilia-are-associated-with-fetal-growth-retardation-in-the-population-of-central-russia
#2
Evgeny Reshetnikov, Oksana Zarudskaya, Alexey Polonikov, Olga Bushueva, Valentina Orlova, Evgeny Krikun, Volodymyr Dvornyk, Mikhail Churnosov
AIM: The aim of this study was to examine the role of hereditary thrombophilia in the development of fetal growth retardation (FGR) in the population of Central Russia. METHODS: The case-control study sample included 497 women in the third trimester of pregnancy recruited during 2009-2013. The participants were enrolled into two groups: patients with FGR (n = 250) and controls without FGR (n = 247). The participants were genotyped for four genetic markers of hereditary thrombophilia: factor V Leiden (G > A FV, rs6025), prothrombin (G > A FII, rs1799963), factor VII (G > A FVII, rs6046), and fibrinogen (G > A FI, rs1800790)...
May 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28544245/ghrelin-receptor-inverse-agonists-as-a-novel-therapeutic-approach-against-obesity-related-metabolic-disease
#3
Kathrin Abegg, Lara Bernasconi, Melanie Hutter, Lynda Whiting, Claudio Pietra, Claudio Giuliano, Thomas A Lutz, Thomas Riediger
AIMS: Ghrelin is implicated in the control of energy balance and glucose homeostasis. The ghrelin receptor exhibits ligand independent constitutive activity, which can be pharmacologically exploited to induce inverse ghrelin actions. Since ghrelin receptor inverse agonists (GHSR-IA) might be effective for the treatment of obesity-related metabolic disease, we tested two novel synthetic compounds GHSR-IA1 and GHSR-IA2. MATERIALS AND METHODS: In functional cell assays, electrophysiogical and immunohistochemical experiments, we demonstrated inverse agonist activity for GHSR-IA1 and GHSR-IA2...
May 24, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28542556/an-inactivated-hand-foot-and-mouth-disease-vaccine-using-the-enterovirus-71-c4a-strain-isolated-from-a-korean-patient-induces-a-strong-immunogenic-response-in-mice
#4
Hyun Ju In, Heeji Lim, Jung-Ah Lee, Hye Jin Kim, Jin-Won Kim, Ji-Yeon Hyeon, Sang-Gu Yeo, June-Woo Lee, Jung Sik Yoo, Young Ki Choi, Sang-Won Lee
Enterovirus 71 (EV71) is a major causative agent of hand-foot-and-mouth disease (HFMD) frequently occurring in children. HFMD induced by EV71 can cause serious health problems and has been reported worldwide, particularly in the Asia-Pacific region. In this study, we assessed the immunogenicity of a formalin-inactivated HFMD vaccine using an EV71 strain (FI-EV71 C4a) isolated from a Korean patient. The vaccine candidate was evaluated in mice to determine the vaccination doses and vaccine schedules. BALB/c mice were intramuscularly administered 5, 10, or 20 μg FI-EV71 vaccine, followed by a booster 2 weeks later...
2017: PloS One
https://www.readbyqxmd.com/read/28540538/impact-of-a-community-based-frailty-intervention-among-middle-aged-and-older-prefrail-and-frail-homeless-women-a-pilot-randomized-controlled-trial
#5
Benissa E Salem, Jennifer Ma-Pham, Stephanie Chen, Mary-Lynn Brecht, Anna Liza Antonio, Masha Ames
Interventions are needed to address frailty and other behaviors (e.g., drug and alcohol use) among prefrail and frail homeless women (P/FHW). The purpose of this pilot randomized controlled trial (RCT) was to compare the efficacy of a Frailty Intervention (FI) versus a Health Promotion (HP) program among P/FHW (N = 32). Structured instruments assessed sociodemographics, individual, situational, health-related, and behavioral factors. While program differences were not statistically significant with the main outcome variables, medium-to-large effect sizes were found in favor of the HP program as it relates to physical and overall frailty, as well as, any drug use, alcohol use, and drug dependency...
May 24, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28537328/frailty-in-relation-to-the-risk-of-alzheimer-s-disease-dementia-and-death-in-older-chinese-adults-a-seven-year-prospective-study
#6
C Wang, X Ji, X Wu, Z Tang, X Zhang, S Guan, H Liu, X Fang
OBJECTIVES: To explore the relationship of general health decline assessed by frailty and risk of dementia and Alzheimer's disease (AD). DESIGN: A seven-year prospective cohort study. SETTING: Secondary analysis of data from the Beijing Longitudinal Study on Aging. PARTICIPANTS: Urban and rural community-dwelling people aged 60 and older at baseline. MEASUREMENTS: Frailty was quantified using the deficit accumulation-based frailty index (FI), constructed from 40 health deficits at baseline...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28536589/the-role-of-polyphenoloxidase-peroxidase-and-%C3%AE-glucosidase-in-phenolics-accumulation-in-olea-europaea-l-fruits-under-different-water-regimes
#7
Marco Cirilli, Giovanni Caruso, Clizia Gennai, Stefania Urbani, Eleonora Frioni, Maurizio Ruzzi, Maurizio Servili, Riccardo Gucci, Elia Poerio, Rosario Muleo
Olive fruits and oils contain an array of compounds that contribute to their sensory and nutritional properties. Phenolic compounds in virgin oil and olive-derived products have been proven to be highly beneficial for human health, eliciting increasing attention from the food industry and consumers. Although phenolic compounds in olive fruit and oil have been extensively investigated, allowing the identification of the main classes of metabolites and their accumulation patterns, knowledge of the molecular and biochemical mechanisms regulating phenolic metabolism remains scarce...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28531254/frailty-status-at-admission-to-hospital-predicts-multiple-adverse-outcomes
#8
Ruth E Hubbard, Nancye M Peel, Mayukh Samanta, Leonard C Gray, Arnold Mitnitski, Kenneth Rockwood
Aims: frailty is proposed as a summative measure of health status and marker of individual vulnerability. We aimed to investigate the discriminative capacity of a frailty index (FI) derived from interRAI Comprehensive Geriatric Assessment for Acute Care (AC) in relation to multiple adverse inpatient outcomes. Methods: in this prospective cohort study, an FI was derived for 1,418 patients ≥70 years across 11 hospitals in Australia. The interRAI-AC was administered at admission and discharge by trained nurses, who also screened patients daily for geriatric syndromes...
May 22, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28529001/a-single-intranasal-administration-of-virus-like-particle-vaccine-induces-an-efficient-protection-for-mice-against-human-respiratory-syncytial-virus
#9
Yue-Ying Jiao, Yuan-Hui Fu, Yi-Fei Yan, Ying Hua, Yao Ma, Xiu-Juan Zhang, Jing-Dong Song, Xiang-Lei Peng, Jiaqiang Huang, Tao Hong, Jin-Sheng He
Human respiratory syncytial virus (RSV) is an important pediatric pathogen causing acute viral respiratory disease in infants and young children. However, no licensed vaccines are currently available. Virus-like particles (VLPs) may bring new hope to producing RSV VLP vaccine with high immunogenicity and safety. Here, we constructed the recombinants of matrix protein (M) and fusion glycoprotein (F) of RSV, respectively into a replication-deficient first-generation adenoviral vector (FGAd), which were used to co-infect Vero cells to assemble RSV VLPs successfully...
May 18, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28524674/holography-of-wi-fi-radiation
#10
Philipp M Holl, Friedemann Reinhard
Wireless data transmission systems such as wi-fi or Bluetooth emit coherent light-electromagnetic waves with a precisely known amplitude and phase. Propagating in space, this radiation forms a hologram-a two-dimensional wave front encoding a three-dimensional view of all objects traversed by the light beam. Here we demonstrate a scheme to record this hologram in a phase-coherent fashion across a meter-sized imaging region. We recover three-dimensional views of objects and emitters by feeding the resulting data into digital reconstruction algorithms...
May 5, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28522306/the-effects-of-chronic-testosterone-administration-on-body-weight-food-intake-and-adipose-tissue-are-changed-by-estrogen-treatment-in-female-rats
#11
Takeshi Iwasa, Toshiya Matsuzaki, Kiyohito Yano, Rie Yanagihara, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Yiliyasi Mayila, Akira Kuwahara, Minoru Irahara
In females, estrogens play pivotal roles in preventing excess body weight (BW) gain. On the other hand, the roles of androgens in female BW, appetite, and energy metabolism have not been fully examined. We hypothesized that androgens' effects on food intake (FI) and BW regulation change according to the estrogens' levels. To evaluate this hypothesis, the effects of chronic testosterone administration in ovariectomized (OVX) female rats with or without estradiol supplementation were examined in this study. Chronic testosterone administration decreased BW, FI, white adipose tissue (WAT) weight, and adipocyte size in OVX rats, whereas it increased BW, WAT weight, and adipocyte size in OVX with estradiol-administered rats...
May 17, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28512271/staining-beverages-and-cigarette-smoke-on-composite-resin-and-human-tooth-fluorescence-by-direct-spectrometry
#12
Tânia Mara da Silva, Natália Yamachita da Silva, Lucélia Lemes Gonçalves, Leandro Procópio Alves, Adjaci Uchoa Fernandes, Sérgio Eduardo de Paiva Gonçalves
INTRODUCTION: This study evaluated the fluorescence intensity (FI) of different brands of composite resins (CRs) and compare those values with the FI of human tooth, under the action of cigarette smoke (CI), coffee (CA), and soft drink (CO), measured by direct spectrometry. MATERIALS AND METHODS: A total of 30 specimens of each brand (Filtek Z350, Esthet-X, Amelogen, Durafill) were made. Others 30 tooth specimens (3 mm/diameter) were obtained from human molars using a trephine bur...
May 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28506296/worlds-apart-a-scoping-review-addressing-different-stakeholder-perspectives-on-barriers-to-family-involvement-in-the-care-for-persons-with-severe-mental-illness
#13
Elleke Landeweer, Bert Molewijk, Marit Helene Hem, Reidar Pedersen
BACKGROUND: Empirical evidence shows that family involvement (FI) can play a pivotal role in the coping and recovery of persons with severe mental illness (SMI). Nevertheless, various studies demonstrate that FI in mental healthcare services is often not (sufficiently) realized. In order to develop more insights, this scoping review gives an overview of how various stakeholders conceptualize, perceive and experience barriers to FI. Central questions are: 1) What are the main barriers to FI reported by the different key stakeholders (i...
May 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28504184/lessons-from-healthcare-utilization-in-children-with-obstructive-sleep-apnoea-syndrome
#14
Paz Martinez-Beneyto, Cristina E Soria Checa, Paloma Botella-Rocamora, Inés Rincon-Piedrahita, Francisco J Garcia Callejo, Jaime Marco Algarra
INTRODUCTION AND OBJECTIVES: Paediatric Obstructive Sleep Apnoea-Hypopnoea Syndrome (OSAS) is a multisystemic condition affecting child's health status that may be investigated analyzing demand for healthcare. OBJECTIVE: to quantify the frequency of medical consultations in children with OSAS over a 5-year period, compared to a healthy population. METHODS: A longitudinal, case-control, ambispective study was conducted at a hospital pertaining to the national public health system...
May 12, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28503570/a-frailty-index-from-next-of-kin-data-a-cross-sectional-analysis-from-the-mexican-health-and-aging-study
#15
Mario Ulises Pérez-Zepeda, Matteo Cesari, María Fernanda Carrillo-Vega, Guillermo Salinas-Escudero, Pamela Tella-Vega, Carmen García-Peña
Objectives. To construct a frailty index from next-of-kin information of the last year of life of community-dwelling 50 years old or older adults and test its association with health services utilization. Methods. Cross-sectional analysis from next-of-kin data available from the last wave of the Mexican Health and Aging Study (MHAS). Measurements. Along with descriptive statistics, the frailty index (FI) was tested in regression models to assess its association with adverse outcomes previous to death: number of hospitalized days in the previous year and number of visits to a physician in the previous year, in unadjusted and adjusted models...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28503081/feeding-intolerance-inflammation-and-neurobehaviors-in-preterm-infants
#16
Tiffany A Moore, Rita H Pickler
PURPOSE: Identifying relationships between feeding intolerance (FI), inflammation, and early measures of neurodevelopment may provide the basis for clinically relevant assessments for NICU clinicians and staff. The purpose of this secondary analysis was to examine the relationship of FI to inflammatory markers and/or neurobehaviors in the first week of life. METHODS: This was a retrospective, matched case-control design with data drawn from 114 infants born at ≤32 weeks gestation...
June 2017: Journal of Neonatal Nursing: JNN
https://www.readbyqxmd.com/read/28502095/the-impact-of-age-and-frailty-on-ventricular-structure-and-function-in-c57bl-6j-mice
#17
H A Feridooni, A E Kane, O Ayaz, A Boroumandi, N Polidovitch, R G Tsushima, R A Rose, S E Howlett
KEY POINTS: Heart size increases with age (called hypertrophy), and its ability to contract declines. However, these reflect average changes that may not be present, or present to the same extent, in all older individuals. That aging happens at different rates is well accepted clinically. People who are aging rapidly are frail and frailty is measured with a 'frailty index'. We quantified frailty with a validated mouse frailty index tool and evaluated the impacts of age and frailty on cardiac hypertrophy and contractile dysfunction...
May 14, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28499965/effects-of-dietary-dandelion-extracts-on-growth-performance-body-composition-plasma-biochemical-parameters-immune-responses-and-disease-resistance-of-juvenile-golden-pompano-trachinotus-ovatus
#18
Xiaohong Tan, Zhenzhu Sun, Shu Chen, Silin Chen, Zhong Huang, Chuanpeng Zhou, Cuiyun Zou, Qingying Liu, Huaqun Ye, Heizhao Lin, Chaoxia Ye, Anli Wang
The present study was conducted to investigate the effects of dietary dandelion extracts (DE) supplementation on growth performance, feed utilization, body composition, plasma biochemical indices, immune responses, hepatic antioxidant abilities, and resistance to the pathogen Vibrio harveyi in Trachinotus ovatus. A basal diet supplemented with DE at 0, 0.50, 1.00, 2.00, 4.00 and 10.00 g kg(-1) were fed to golden pompano for 8 weeks. The study indicated that dietary supplementation with DE could significantly improve final body weight (FBW), weight gain rate (WGR), specific growth rate (SGR), feed efficiency ratio (FER), feed intake (FI), protein efficiency ratio (PER) and protein deposit rate (PDR) (P < 0...
May 9, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28499420/continuous-femoral-nerve-blockade-and-single-shot-sciatic-nerve-block-promotes-better-analgesia-and-lower-bleeding-for-total-knee-arthroplasty-compared-to-intrathecal-morphine-a-randomized-trial
#19
Nora Elizabeth Rojas Álvarez, Rosemberg Jairo Gomez Ledesma, Adilson Hamaji, Marcelo Waldir Mian Hamaji, Joaquim Edson Vieira
BACKGROUND: Knee arthroplasty leads to postoperative pain. This study compares analgesia and postoperative bleeding achieved by intrathecal morphine with a continuous femoral plus single-shot sciatic nerve block. METHODS: A randomized non-blinded clinical trial enrolled patients aged over 18 years old, ASA I to III who underwent total knee arthroplasty. All patients underwent spinal anesthesia with isobaric bupivacaine, 20 mg. One group received 100 mcg of intrathecal morphine (M group), and the other received a femoral nerve block by continuous infusion plus a "single shot" block of the sciatic nerve at the end of the surgery (FI group)...
May 12, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28494165/effect-of-feed-supplementation-with-satureja-khuzistanica-essential-oil-on-performance-and-physiological-parameters-of-broilers-fed-on-wheat-or-maize-based-diets
#20
L Masouri, S Salari, M Sari, S Tabatabaei, B Masouri
1. The aim of this study was to evaluate various levels of Satureja Khuzistanica essential oil (SKEO) on performance and physiological parameters of broilers fed on wheat- or maize-based diets. 2. Treatments consisted of two cereals (maize or wheat-based diets) and 3 levels of SKEO)0, 250 and 500 mg/kg). 3. Feed intake (FI) and body weight gain (BWG) decreased in broilers fed on the wheat-based diets compared to the control diet. Dietary supplementation of 500 mg/kg SKEO increased FI and BWG. Dietary SKEO supplementation was effective in improving FI and BWG only in wheat-based diets and was effective in improving FCR in both diets...
May 11, 2017: British Poultry Science
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