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https://www.readbyqxmd.com/read/27913883/on-the-prevalence-of-constipation-and-fecal-incontinence-and-their-co-occurrence-in-the-netherlands
#1
Rob J Meinds, Maxime M van Meegdenburg, Monika Trzpis, Paul M A Broens
PURPOSE: Numerous studies have investigated the prevalence of constipation and fecal incontinence (FI) in the general population and, even though these disorders are known to co-occur, they were studied independently of each other. Our aim was to investigate the prevalence of constipation and FI, and their co-occurrence, in the general population in the Netherlands. METHODS: We studied a cross-section of the Dutch population (N = 1259). All respondents completed the Groningen Defecation & Fecal Continence checklist...
December 2, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27913722/impact-of-a-multidisciplinary-round-visit-for-the-management-of-dysphagia-utilizing-a-wi-fi-based-wireless-flexible-endoscopic-evaluation-of-swallowing
#2
Koichi Sakakura, Masayuki Tazawa, Natsuko Otani, Masato Takagi, Mariko Morita, Minori Kurosaki, Tomoko Chiyoda, Yuri Kanai, Ayaka Endo, Takaaki Murata, Masato Shino, Yuki Yokobori, Kenji Shirakura, Naoki Wada, Kazuaki Chikamatsu
OBJECTIVES: The management of dysphagia requires a multidisciplinary approach, especially in large-scale hospitals. We introduce a novel protocol using a Wi-Fi-based flexible endoscopic evaluation of swallowing (FEES) system and aim to verify its effectiveness in evaluation and rehabilitation of inpatients with dysphagia. METHOD: We conducted novel Wi-Fi-based FEES at the bedside using 3 iPads as monitors and recorders. Functional outcomes of swallowing in 2 different hospitals for acute care with conventional wired or wireless FEES were compared retrospectively...
January 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27913614/relationship-between-employment-histories-and-frailty-trajectories-in-later-life-evidence-from-the-english-longitudinal-study-of-ageing
#3
Wentian Lu, Rebecca Benson, Karen Glaser, Loretta G Platts, Laurie M Corna, Diana Worts, Peggy McDonough, Giorgio Di Gessa, Debora Price, Amanda Sacker
BACKGROUND: Given the acceleration of population ageing and policy changes to extend working lives, evidence is needed on the ability of older adults to work for longer. To understand more about the health impacts of work, this study examined the relationship between employment histories before retirement and trajectories of frailty thereafter. METHODS: The sample comprised 2765 women and 1621 men from the English Longitudinal Study of Ageing. We used gendered typologies of life-time employment and a frailty index (FI)...
December 2, 2016: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/27908675/effect-of-polymers-in-moisture-sorption-and-physical-stability-of-polymorphic-olanzapine
#4
Maria C Paisana, Martin A Wahl, F João
The study aims to elucidate the transformations of anhydrous olanzapine Form I (OLZ FI) into the hydrate forms, when stored at a high relative humidity or suspended in an aqueous media, in the presence of polymers. OLZ FI and physical mixtures (3:1 and 1:1, as powders or compacts) of olanzapine with polyethylene glycol (PEG-6000), polyvinylpyrrolidone (PVP K25) and hydroxypropylcellulose (HPC-LF) were stored (75%RH/25°C, 75%RH/40°C and 93%RH/25°C) for 28days. OLZ FI and the physical mixtures were also suspended in water under stirring (200rpm/60min)...
November 28, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27903307/the-cumulative-effect-of-frailty-and-cognition-on-mortality-results-of-a-prospective-cohort-study
#5
Philip D St John, Suzanne L Tyas, Lauren E Griffith, Verena Menec
BACKGROUND: Both physical frailty and cognitive impairment predict death, but the joint effect of these two factors is uncertain. The objectives are to determine if the Mini-mental state examination (MMSE) and the Frailty Index (FI) predict death over a five-year interval after accounting for the effect of the other; and if there is an interaction in this effect. METHODS: An analysis of an existing prospective cohort study of 1,751 community living older adults followed over a five-year time frame...
December 1, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27900297/effects-of-lymphatic-drainage-and-local-cryo-exposition-regeneration-after-high-intensive-exercises
#6
Michael Behringer, Diana Jedlicka, Molly McCourt, Matthias Ring, Joachim Mester
BACKGROUND: Recovery from exercise and competition is important in sports medicine, particularly when rest periods are short. The objective is to determine the efficacy of cryo exposition (CRY) and manual lymphatic drainage (MLD) to hasten short term recovery of muscle performance after eccentric contractions. METHODS: In a randomized controlled trial, 30 healthy sport students (21 males, 9 females; age: 25.7±2.8 years) performed 4×20 eccentric contractions of knee extensors, followed by 30 min MLD, CRY, or rest (RST) under controlled laboratory environment...
April 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27899040/clinical-role-of-fluorescence-imaging-in-colorectal-surgery-a-review
#7
Ido Mizrahi, Steven D Wexner
Introduction Anastomotic leak (AL) after colorectal surgery is a devastating complication; decreased blood perfusion is an important risk factor. Surgeons rely on subjective measures to assess bowel perfusion. Fluorescence imaging (FI) with indocyanine green (ICG) provides a real-time objective assessment of intestinal perfusion. Areas Covered A Pubmed search using the terms 'fluorescence imaging', 'indocyanine green', 'colon and rectal surgery' was undertaken. Sixteen articles between 2010 to present were identified...
November 30, 2016: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/27898849/effects-of-feed-intake-and-dietary-nutrient-density-on-apparent-ileal-and-total-tract-digestibility-of-nutrients-and-gross-energy-for-growing-pigs
#8
J B Liu, Z Q Liu, L Chen, H F Zhang
The present study was conducted to investigate the effects of feed intake (FI) and dietary nutrient concentration on the determination of apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of nutrients and GE for growing pigs. A total of 48 growing pigs (40.7 ± 1.3 kg initial BW) were surgically fitted with simple T-cannulas at the distal ileum and assigned to 6 treatment groups in a 2 × 3 factorial arrangement of 2 diets (a low-nutrient-density [LND] diet or a normal-nutrient-density [NND] diet) and 3 FI levels (3, 4 or 5% of BW per day)...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898840/one-hour-portable-chamber-methane-measurements-are-repeatable-and-provide-useful-information-on-feed-intake-and-efficiency
#9
D L Robinson, M Cameron, A J Donaldson, S Dominik, V H Oddy
Feed intake (FI), live weight (LW), and ADG were recorded over 31 d in ninety-six 12-month-old ewes (progeny of 4 sires) given ad libitum access to chaffed lucerne/cereal hay. Methane (CH) and CO emissions of each ewe were measured for 40 to 60 min in portable accumulation chambers (PAC) and in respiration chambers (RC) over 22 h. Testing in RC increased the variability of FI on the test day and depressed the amount eaten from an average of 1,384 to 1,062 g/d; FI depression increased by 0.63 ± 0.24 percentage points for every kilogram of additional LW...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27896796/development-and-validation-of-a-frailty-index-in-the-longitudinal-aging-study-amsterdam
#10
Emiel O Hoogendijk, Olga Theou, Kenneth Rockwood, Bregje D Onwuteaka-Philipsen, Dorly J H Deeg, Martijn Huisman
BACKGROUND: Frailty is a state of increased vulnerability to adverse outcomes. The frailty index (FI), defined by the deficit accumulation approach, is a sensitive instrument to measure levels of frailty, and therefore important for longitudinal studies of aging. AIMS: To develop an FI in the Longitudinal Aging Study Amsterdam (LASA), and to examine the predictive validity of this FI for 19-year mortality. METHODS: LASA is an ongoing study among Dutch older adults, based on a nationally representative sample...
November 28, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27886524/effects-of-ethanol-on-cocaine-self-administration-in-monkeys-responding-under-a-second-order-schedule-of-reinforcement
#11
William S John, Michael A Nader
BACKGROUND: Concurrent alcohol use among cocaine abusers is common but the behavioral variables that promote co-abuse are not well understood. The present study examined the effects of intragastric (i.g.) ethanol (EtOH) administration in monkeys responding under a schedule of cocaine reinforcement in which extensive drug seeking was maintained by conditioned stimuli. METHODS: Four adult male cynomolgus monkeys (Macaca fascicularis) were trained to respond under a second-order fixed-interval (FI) 600s (fixed-ratio (FR) 30:S) schedule of cocaine (0...
November 10, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27885800/sacral-neuromodulation-for-the-treatment-of-faecal-incontinence-following-proctectomy
#12
Ido Mizrahi, Sami A Chadi, Nadav Haim, Dana R Sands, Brooke Gurland, Massarat Zutshi, Steven D Wexner, Giovanna da Silva
AIM: This study assessed the effectiveness of sacral neuromodulation (SNM) for faecal incontinence (FI) following proctectomy with colorectal or coloanal anastomosis. METHODS: An IRB-approved database identified patients treated for FI following proctectomy (SNM-P) for benign or malignant disease, who were matched 1:1 by pre-operative Cleveland Clinic Florida Faecal Incontinence Scores (CCF-FIS) with patients without proctectomy (SNM-NP). Primary outcome was change in CCF-FIS...
November 25, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27885682/fractional-laser-assisted-drug-uptake-impact-of-time-related-topical-application-to-achieve-enhanced-delivery
#13
Christina A Banzhaf, Daniel Thaysen-Petersen, Christiane Bay, Peter A Philipsen, Mette Mogensen, Tarl Prow, Merete Haedersdal
BACKGROUND AND OBJECTIVE: Ablative fractional laser (AFXL) is acknowledged to increase uptake of topically applied agents in skin. AFXL channels gradually close over time, which may impair this capability. The time frame for applying a drug after AFXL exposure remains to be established. The aim of this study, was to investigate the importance of time-related topical application after AFXL exposure and to relate resultant uptake in skin with AFXL channel morphology and skin integrity. STUDY DESIGN/MATERIALS AND METHODS: Buttock skin of healthy volunteers (n = 11) was exposed to 10,600 nm fractional CO2 laser using 5% density, 120 μm beam diameter, 15 mJ pulse energy...
November 25, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27885087/long-term-electromagnetic-field-measurement-and-assessment-for-a-shopping-mall
#14
Begum Korunur Engiz, Cetin Kurnaz
As a result of the dense deployment of wireless devices and base stations, measuring and evaluating the electromagnetic (EM) exposure levels they emit have become important to human health especially if they exceed the limits defined in the standards. Base stations, Wi-Fi equipment and other electronic devices are used heavily, especially in densely crowded places like shopping centers. In this study, electric field strength (E) measurements were conducted at one of the largest shopping malls in Turkey. Broadband E measurements were performed using PMM 8053 EM field strength meter for 24 h a day for the duration of one week while frequency selective measurements were carried out with SRM-3006 EM field strength meter...
November 24, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27885038/design-fiction-and-the-medical-humanities
#15
Christopher Gordon Strachan
This paper sets out to explore the similarities between the developing discipline of speculative and critical design (SCD) and science fiction, and their relevance to the medical humanities. SCD looks beyond 'commercial design' to consider what sort of things we should, or should not, be designing in order to create preferable futures. It does so by extrapolating from current social, economic, political and scientific knowledge, designing artefacts, experiences and scenarios which communicate futures and alternative realities in tangible ways...
December 2016: Medical Humanities
https://www.readbyqxmd.com/read/27883172/can-an-intervention-with-testosterone-and-nutritional-supplement-improve-the-frailty-level-of-under-nourished-older-people
#16
O Theou, I Chapman, L Wijeyaratne, C Piantadosi, K Lange, V Naganathan, P Hunter, I D Cameron, K Rockwood, R Visvanathan
OBJECTIVE: To examine whether a testosterone and a high calorie nutritional supplement intervention can reduce frailty scores in undernourished older people using multiple frailty tools. DESIGN: Randomized controlled trial. SETTING/PARTICIPANTS: 53 community-dwelling, undernourished men and women aged >65 years from South Australia, Victoria and New South Wales. INTERVENTION: Intervention group received oral testosterone undecanoate and a high calorie supplement (2108-2416 kJ/day) whereas the control group received placebo testosterone and low calorie supplement (142-191 kJ/day)...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27881404/novel-insights-into-fecal-incontinence-in-men
#17
Yoav Mazor, Michael Jones, Alison Andrews, John E Kellow, Allison Malcolm
Fecal incontinence (FI) in men is common yet data on gender differences in clinical features, physiology and treatment is scarce. Our aim was to provide insights into FI in males compared to females. Prospectively collected data from 73 men and 596 women with FI in a tertiary referral centre was analysed. Anorectal physiology, clinical characteristics and outcome of instrumented biofeedback (BF) was recorded. 31 men with FI proceeded to BF and were matched with 62 age-matched women with FI who underwent BF...
November 23, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27874109/molecular-electrometer-and-binding-of-cations-to-phospholipid-bilayers
#18
Andrea Catte, Mykhailo Girych, Matti Javanainen, Claire Loison, Josef Melcr, Markus S Miettinen, Luca Monticelli, Jukka Määttä, Vasily S Oganesyan, O H Samuli Ollila, Joona Tynkkynen, Sergey Vilov
Despite the vast amount of experimental and theoretical studies on the binding affinity of cations - especially the biologically relevant Na(+) and Ca(2+) - for phospholipid bilayers, there is no consensus in the literature. Here we show that by interpreting changes in the choline headgroup order parameters according to the 'molecular electrometer' concept [Seelig et al., Biochemistry, 1987, 26, 7535], one can directly compare the ion binding affinities between simulations and experiments. Our findings strongly support the view that in contrast to Ca(2+) and other multivalent ions, Na(+) and other monovalent ions (except Li(+)) do not specifically bind to phosphatidylcholine lipid bilayers at sub-molar concentrations...
November 30, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27873101/relationship-between-blood-pressure-and-frailty-in-older-hypertensive-outpatients
#19
Giorgio Basile, Antonino Catalano, Giuseppe Mandraffino, Giuseppe Maltese, Angela Alibrandi, Giuliana Ciancio, Antonino Lasco, Matteo Cesari
BACKGROUND: The benefits and risks of treating hypertension in old and frail patients are debated. AIM: The aim of the present study is to measure the frailty status in older patients with hypertension and determine the relationships existing between blood pressure (BP) values and frailty. METHODS: Frailty was retrospectively assessed by using the frailty index (FI) in 56 hypertensive old outpatients. Patients with an FI > 0.25 were classified as frail...
November 21, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27871565/postoperative-analgesic-efficacy-of-fascia-iliaca-block-versus-periarticular-injection-for-total-knee-arthroplasty
#20
Cagla Bali, Ozlem Ozmete, H Evren Eker, Murat A Hersekli, Anis Aribogan
STUDY OBJECTIVE: This study evaluated the postoperative analgesic efficacies of fascia iliaca block and periarticular drug injection techniques after TKA (total knee arthroplasty) surgeries. DESIGN: Prospective, randomized clinical trial. SETTING: University Teaching and Research Center. PATIENTS: Seventy-one American Society of Anesthesiologists (ASA) I-III patients between 48 and 70 years of age who underwent total knee arthroplasty were randomized...
December 2016: Journal of Clinical Anesthesia
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