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https://www.readbyqxmd.com/read/28229523/pathophysiology-of-fecal-incontinence-in-obese-patients-a-prospective-case-matched-study-of-201-patients
#1
C Brochard, A Vénara, A Bodère, A Ropert, G Bouguen, L Siproudhis
BACKGROUND: Obesity is an emerging risk factor for fecal incontinence (FI). The aim of this study was to characterize pathophysiologic mechanisms of FI in obese patients compared with non-obese patients in a prospective case-matched study. METHODS: The general characteristics and data of the anorectal manometry and endosonography of patients who were evaluated for FI at a single institution from 2005 to 2015 were prospectively assessed. Fecal incontinence was defined by a Cleveland Clinic Incontinence Score (CCIS) >4...
February 23, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28228654/low-ft3-a-possible-marker-of-frailty-in-the-elderly
#2
Aldo Bertoli, Alessia Valentini, Maria Assunta Cianfarani, Elena Gasbarra, Umberto Tarantino, Massimo Federici
INTRODUCTION: Frailty is associated with a functional decline of multiple physiological systems, of which they may be a cause or consequence. The objective of the study was to evaluate the prevalence of thyroid hormone modifications in elderly frail subjects and its relationship with frailty. STUDY POPULATION AND METHODS: An observational study was carried out at the University Hospital "Tor Vergata" in Rome among ambulatory and hospitalized patients. The study population consisted of 112 elderly subjects: 62 were hospitalized following hip fracture and 50 control subjects were outpatients...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28228587/prophylactic-herpes-simplex-virus-2-hsv-2-vaccines-adjuvanted-with-stable-emulsion-and-toll-like-receptor-9-agonist-induce-a-robust-hsv-2-specific-cell-mediated-immune-response-protect-against-symptomatic-disease-and-reduce-the-latent-viral-reservoir
#3
Michael T Hensel, Jason D Marshall, Michael R Dorwart, Darren S Heeke, Eileen Rao, Padmaja Tummala, Li Yu, Gary H Cohen, Roselyn J Eisenberg, Derek D Sloan
Several prophylactic vaccines targeting HSV-2 have failed in the clinic to demonstrate a sustained depression in viral shedding or protection from recurrences. Although these vaccines have generated high titers of neutralizing antibodies, their induction of robust CD8 T cells has largely been unreported, even though evidence for the importance of HSV-2 antigen-specific CD8 T cells is mounting in animal models and in translational studies involving subjects with active HSV-2-specific immune responses. We developed a subunit vaccine composed of the neutralizing antibody (nAb) targets gD and gB, the novel T cell antigen and tegument protein UL40, and we compared this to a whole-inactivated virus vaccine (FI-HSV-2)...
February 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28227593/an-rf-based-wearable-sensor-system-for-indoor-tracking-to-facilitate-efficient-healthcare-management
#4
Yuzhe Ouyang, Kai Shan, Francis Minhthang Bui, Yuzhe Ouyang, Kai Shan, Francis Minhthang Bui, Yuzhe Ouyang, Kai Shan, Francis Minhthang Bui
To understand the utilization of clinical resources and improve the efficiency of healthcare, it is often necessary to accurately locate patients and doctors in a healthcare facility. However, existing tracking methods, such as GPS, Wi-Fi and RFID, have technological drawbacks or impose significant costs, thus limiting their applications in many clinical environments, especially those with indoor enclosures. This paper proposes a low-cost and flexible tracking system that is well suited for operating in an indoor environment...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226579/a-deep-convolutional-neural-network-for-bleeding-detection-in-wireless-capsule-endoscopy-images
#5
Xiao Jia, Max Q-H Meng, Xiao Jia, Max Q-H Meng, Xiao Jia, Max Q-H Meng
Wireless Capsule Endoscopy (WCE) is a standard non-invasive modality for small bowel examination. Recently, the development of computer-aided diagnosis (CAD) systems for gastrointestinal (GI) bleeding detection in WCE image videos has become an active research area with the goal of relieving the workload of physicians. Existing methods based primarily on handcrafted features usually give insufficient accuracy for bleeding detection, due to their limited capability of feature representation. In this paper, we present a new automatic bleeding detection strategy based on a deep convolutional neural network and evaluate our method on an expanded dataset of 10,000 WCE images...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226569/flexible-sliding-frame-for-gait-enhancing-mechatronic-system-gems
#6
Younbaek Lee, Byungjung Choi, Jongwon Lee, Minhyung Lee, Se-Gon Roh, Jeonghun Kim, Hyundo Choi, Yong-Jae Kim, Younbaek Lee, Byungjung Choi, Jongwon Lee, Minhyung Lee, Se-Gon Roh, Jeonghun Kim, Hyundo Choi, Yong-Jae Kim, Minhyung Lee, Jeonghun Kim, Hyundo Choi, Younbaek Lee, Se-Gon Roh, Byungjung Choi, Jongwon Lee, Yong-Jae Kim
This paper presents a novel flexible sliding thigh frame for a gait enhancing mechatronic system. With its two-layered unique structure, the frame is flexible in certain locations and directions, and stiff at certain other locations, so that it can fît well to the wearer's thigh and transmit the assisting torque without joint loading. The paper describes the basic mechanics of this 3D flexible frame and its stiffness characteristics. We implemented the 3D flexible frame on a gait enhancing mechatronic system and conducted experiments...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223831/cost-analysis-of-facial-injury-treatment-in-two-university-hospitals-in-malaysia-a-prospective-study
#7
Bin Sulong Saperi, Roszalina Ramli, Zafar Ahmed, Amrizal Muhd Nur, Mohd Ismail Ibrahim, Muhd Fazlynizam Rashdi, Rifqah Nordin, Normastura Abd Rahman, Azizah Yusoff, Abd Jabar Nazimi, Roselinda Abdul Rahman, Noorhayati Abdul Razak, Norlen Mohamed
OBJECTIVE: Facial injury (FI) may occur in isolation or in association with injuries to other parts of the body (facial and other injury [FOI]). The objective of this study was to determine the direct treatment costs incurred during the management of facial trauma. MATERIALS AND METHODS: A prospective cohort study on treatment cost for FIs and FOIs due to road-traffic crashes in two university hospitals in Malaysia was conducted from July 2010 to June 2011. The patients were recruited from emergency departments and reviewed after 6 months from the date of initial treatment...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28223787/comparing-the-predictive-accuracy-of-frailty-comorbidity-and-disability-for-mortality-a-1-year-follow-up-in-patients-hospitalized-in-geriatric-wards
#8
Martin Ritt, Julia Isabel Ritt, Cornel Christian Sieber, Karl-Günter Gaßmann
BACKGROUND: Studies evaluating and comparing the power of frailty, comorbidity, and disability instruments, together and in parallel, for predicting mortality are limited. OBJECTIVE: This study aimed to evaluate and compare the measures of frailty, comorbidity, and disability in predicting 1-year mortality in geriatric inpatients. DESIGN: Prospective cohort study. PATIENTS AND SETTING: A total of 307 inpatients aged ≥65 years in geriatric wards of a general hospital participated in the study...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28214554/c21-steroidal-glycosides-and-oligosaccharides-from-the-root-bark-of-periploca-sepium
#9
Xin-Yue Gu, Zhou-Wei Wu, Lun Wang, Fu Li, Bin Chen, Kai Yu, Ming-Kui Wang
Four new C21 steroidal glycosides (1-4), named perisepiumosides FI (1-4) together with six known steroidal glycosides (5-10) and four oligosaccharides (11-14), were isolated from the root bark of Periploca sepium. Their structures were characterized on the basis of 1D and 2D-NMR spectroscopic data as well as HR-ESI-MS analysis. The evaluation of inhibition activity against human A-549 and HepG2 cell lines indicated that compounds 2, 8, 10 and 13 showed different levels of cytotoxic activities with IC50 values ranging from 0...
February 16, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28213255/amperometric-flow-injection-analysis-of-glucose-using-immobilized-glucose-oxidase-on-nano-composite-carbon-nanotubes-platinum-nanoparticles-carbon-paste-electrode
#10
Maliwan Amatatongchai, Wongduan Sroysee, Sanoe Chairam, Duangjai Nacapricha
We report a novel amperometric glucose biosensor based on glucose oxidase (GOx) immobilized on a carbon nanotube (CNTs)-poly(diallyldimethyl-ammonium chloride) (PDDA)-platinum nanoparticle (PtNPs) modified carbon-paste electrode (CNTs-PDDA-PtNPs/CPE). The CNTs-PDDA-PtNPs composite materials were characterized by TEM and electrochemical techniques. Cyclic voltammetric results reveal direct electron transfer of the immobilized GOx, indicated by two quasi-reversible redox peaks at a potential of 0.37V (vs. Ag/AgCl) in phosphate buffered solution (PBS) (0...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28209529/menopausal-hormone-therapy-is-associated-with-increased-risk-of-fecal-incontinence-in-women-after-menopause
#11
Kyle Staller, Mary K Townsend, Hamed Khalili, Raaj Mehta, Francine Grodstein, William E Whitehead, Catherine A Matthews, Braden Kuo, Andrew T Chan
BACKGROUND & AIMS: Low estrogen levels could contribute to development of fecal incontinence (FI) in women after menopause by altering neuromuscular continence mechanisms. However, studies have produced conflicting results on the association between menopausal hormone therapy (MHT) and risk of FI. METHODS: We studied the association between MHT and risk of FI among 55,828 post-menopausal women (mean age 73 years) who participated in the Nurses' Health Study, enrolled since 2008, with no report of FI...
February 13, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28209135/marv-a-tool-for-genome-wide-multi-phenotype-analysis-of-rare-variants
#12
Marika Kaakinen, Reedik Mägi, Krista Fischer, Jani Heikkinen, Marjo-Riitta Järvelin, Andrew P Morris, Inga Prokopenko
BACKGROUND: Genome-wide association studies have enabled identification of thousands of loci for hundreds of traits. Yet, for most human traits a substantial part of the estimated heritability is unexplained. This and recent advances in technology to produce high-dimensional data cost-effectively have led to method development beyond standard common variant analysis, including single-phenotype rare variant and multi-phenotype common variant analysis, with the latter increasing power for locus discovery and providing suggestions of pleiotropic effects...
February 16, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28207907/argon-does-not-affect-cerebral-circulation-or-metabolism-in-male-humans
#13
Frank Grüne, Stephan Kazmaier, Sanne Elisabeth Hoeks, Robert Jan Stolker, Marc Coburn, Andreas Weyland
OBJECTIVE: Accumulating data have recently underlined argon´s neuroprotective potential. However, to the best of our knowledge, no data are available on the cerebrovascular effects of argon (Ar) in humans. We hypothesized that argon inhalation does not affect mean blood flow velocity of the middle cerebral artery (Vmca), cerebral flow index (FI), zero flow pressure (ZFP), effective cerebral perfusion pressure (CPPe), resistance area product (RAP) and the arterio-jugular venous content differences of oxygen (AJVDO2), glucose (AJVDG), and lactate (AJVDL) in anesthetized patients...
2017: PloS One
https://www.readbyqxmd.com/read/28207670/feasibility-study-of-utilization-of-action-camera-gopro-hero-4-google-glass-and-panasonic-hx-a100-in-spine-surgery
#14
Chang Kyu Lee, Youngjun Kim, Nam Lee, Byeongwoo Kim, Doyoung Kim, Seong Yi
STUDY DESIGN: Study for feasibility of commercially available action cameras in recording video of spine. OBJECTIVE: Recent innovation of the wearable action camera with high-definition video recording enables surgeons to use camera in the operation at ease without high costs. The purpose of this study is to compare the feasibility, safety, and efficacy of commercially available action cameras in recording video of spine surgery. SUMMARY OF BACKGROUND DATA: There are early reports of medical professionals using Google Glass throughout the hospital, Panasonic HX-A100 action camera, and GoPro...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28203122/evaluation-of-the-effect-of-radiofrequency-radiation-emitted-from-wi-fi-router-and-mobile-phone-simulator-on-the-antibacterial-susceptibility-of-pathogenic-bacteria-listeria-monocytogenes-and-escherichia-coli
#15
M Taheri, S M J Mortazavi, M Moradi, S Mansouri, G R Hatam, F Nouri
Mobile phones and Wi-Fi radiofrequency radiation are among the main sources of the exposure of the general population to radiofrequency electromagnetic fields (RF-EMF). Previous studies have shown that exposure of microorganisms to RF-EMFs can be associated with a wide spectrum of changes ranged from the modified bacterial growth to the alterations of the pattern of antibiotic resistance. Our laboratory at the nonionizing department of the Ionizing and Non-ionizing Radiation Protection Research Center has performed experiments on the health effects of exposure to animal models and humans to different sources of electromagnetic fields such as cellular phones, mobile base stations, mobile phone jammers, laptop computers, radars, dentistry cavitrons, magnetic resonance imaging, and Helmholtz coils...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28203006/-observation-of-bone-morphology-in-furcation-defects-of-mandibular-molars-using-cone-beam-computed-tomography
#16
J Zhu, X Y Ouyang
OBJECTIVE: To observe mesial-distal bone morphology in classes II and III furcation involvements (FI) of mandibular molars using cone beam computed tomography (CBCT), to develop a classification system of mesial-distal bone morphology of furcation defects and to observe the intrabony defects on CBCT images. METHODS: Based on the existing CBCT data, the mandibular molars with horizontal bone defects in furcation area were observed. One hundred and seventeen sites of 81 mandibular molars with class II or class III FIclassified on CBCT images were included...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28197646/an-observational-follow-up-study-on-pelvic-floor-disorders-to-3-5-years-after-delivery
#17
Karen Ng, Rachel Yau Kar Cheung, Lai Loi Lee, Tony Kwok Hung Chung, Symphorosa Shing Chee Chan
INTRODUCTION AND HYPOTHESIS: This study aimed to determine the prevalence of urinary incontinence (UI), fecal incontinence (FI), and pelvic organ prolapse (POP) 3-5 years after the first pregnancy and their associated risk factors. METHODS: We assessed 506 women using the Pelvic Floor Distress Inventory (PFDI) and the Pelvic Floor Impact Questionnaire (PFIQ). Maternal characteristics and obstetric data were analyzed using descriptive analysis, independent sample t test, chi-squared test, and logistic regression...
February 14, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28194667/three-dimensional-anorectal-manometry-enhances-diagnostic-gain-by-detecting-sphincter-defects-and-puborectalis-pressure
#18
Shreya Raja, Francis C Okeke, Ellen M Stein, Sameer Dhalla, Monica Nandwani, Kristle L Lynch, C Prakash Gyawali, John O Clarke
BACKGROUND: Constipation and fecal incontinence (FI) are common and are often evaluated with anorectal manometry. Three-dimensional high-resolution anorectal manometry (HRAM) is a promising technology; however, implementation has been limited by lack of metrics and unclear clinical utility. AIM: To investigate the diagnostic utility of 3D HRAM compared to 2D HRAM. METHODS: Three-dimensional HRAM studies performed from April 2012 to October 2013 were identified and re-interpreted by two blinded investigators examining 3D function...
February 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28190980/effect-of-low-dose-short-term-creatine-supplementation-on-muscle-power-output-in-elite-youth-soccer-players
#19
Aquiles Yáñez-Silva, Cosme F Buzzachera, Ivan Da C Piçarro, Renata S B Januario, Luis H B Ferreira, Steven R McAnulty, Alan C Utter, Tacito P Souza-Junior
BACKGROUND: To determine the effects of a low dose, short-term Creatine monohydrate (Cr) supplementation (0.03 g.kg.d(-1) during 14 d) on muscle power output in elite youth soccer players. METHODS: Using a two-group matched, double blind, placebo-controlled design, nineteen male soccer players (mean age = 17.0 ± 0.5 years) were randomly assigned to either Cr (N = 9) or placebo (N = 10) group. Before and after supplementation, participants performed a 30s Wingate Anaerobic Test (WAnT) to assess peak power output (PPO), mean power output (MPO), fatigue index (FI), and total work...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28186208/preclinical-evaluation-of-bacterially-produced-rsv-g-protein-vaccine-strong-protection-against-rsv-challenge-in-cotton-rat-model
#20
Sandra Fuentes, Laura Klenow, Hana Golding, Surender Khurana
In current study, we evaluated the safety and protective efficacy of recombinant unglycosylated RSV G protein ectodomain produced in E. coli (in presence and absence of oil-in-water adjuvant) in a preclinical RSV susceptible cotton rat challenge model compared to formaldehyde inactivated RSV (FI-RSV) and live RSV experimental infection. The adjuvanted G protein vaccine induced robust neutralization antibody responses comparable to those generated by live RSV infection. Importantly, adjuvanted G protein significantly reduced viral loads in both the lungs and nose at early time points following viral challenge...
February 10, 2017: Scientific Reports
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