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https://www.readbyqxmd.com/read/28443064/loss-of-vagal-sensitivity-to-cholecystokinin-in-rats-born-with-intrauterine-growth-retardation-and-consequence-on-food-intake
#1
Marième Ndjim, Camille Poinsignon, Patricia Parnet, Gwenola Le Dréan
Perinatal malnutrition is associated with low birth weight and an increased risk of developing metabolic syndrome in adulthood. Modification of food intake (FI) regulation was observed in adult rats born with intrauterine growth retardation induced by maternal dietary protein restriction during gestation and maintained restricted until weaning. Gastrointestinal peptides and particularly cholecystokinin (CCK) play a major role in short-term regulation of FI by relaying digestive signals to the hindbrain via the vagal afferent nerve (VAN)...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28440408/identification-of-potential-gene-targets-in-systemic-vasculitis-using-dna-microarray-analysis
#2
Yiwen Feng, Miao Zheng, Shujie Gan, Lei Zhang, Zhong Wan, Yanping Zhang, Qin Qian, Jingdong Tang
The present study aimed to identify the involvement of critical genes in systemic vasculitis, to gain an improved understanding of the molecular circuity and to investigate novel potential gene targets for systemic vasculitis treatment. The dual‑color cDNA microarray data of GSE16945, consisting of peripheral mononuclear blood cell specimens from 13 patients with systemic vasculitis and 16 healthy controls, was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were screened in systemic vasculitis compared with controls using BRB ArrayTools, followed by the construction of a protein‑protein interaction (PPI) network using the clusterProfiler package, and significant functional interaction (FI) module selection...
April 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28439921/impact-of-obstructive-sleep-apnoea-and-intermittent-hypoxia-on-cardiovascular-and-cerebrovascular-regulation
#3
Andrew E Beaudin, Xavier Waltz, Patrick J Hanly, Marc J Poulin
Obstructive sleep apnoea (OSA) is associated with increased risk of cardiovascular and cerebrovascular disease, a consequence attributed in part to chronic intermittent hypoxia (IH) resulting from repetitive apnoeas during sleep. Although findings from experimental animal, and human, models have shown that IH is detrimental to vascular regulation, the severity of IH used in many of these animal studies (e.g. inspired fraction of oxygen (FI O2 ) = 2-3%; oxygen desaturation index (ODI) = 120 events h(-1) ) is considerably greater than that observed in the majority of patients with OSA...
April 24, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28436201/brain-responses-to-mechanical-rectal-stimuli-in-patients-with-faecal-incontinence-an-fmri-study
#4
Naseem Mirbagheri, Sean Hatton, Kheng-Seong Ng, Jim Lagopoulos, Marc A Gladman
AIM: Continence is dependent on anorectal/brain interactions. Consequently, aberrations of the brain-gut axis may be important in the pathophysiology of faecal incontinence (FI) in certain patients. The aim of this study was to assess the feasibility of recording brain responses to rectal mechanical stimuli in patients with FI using functional Magnetic Resonance Imaging (fMRI). METHOD: A prospective, cohort pilot study was performed to assess brain responses during rectal stimulation in 14 patients (4 male, mean [SD] age 62 [15] years)...
April 24, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28435141/thermodynamic-investigation-of-carbamazepine-saccharin-co-crystal-polymorphs
#5
Sudhir K Pagire, Niten Jadav, Venu R Vangala, Benjamin Whiteside, Anant Paradkar
Polymorphism in active pharmaceutical ingredients (APIs) can be regarded as critical for the potential that crystal form can have on the quality, efficacy and safety of the final drug product. The current contribution aims to characterize thermodynamic interrelationship of a dimorphic co-crystal, FI and FII, involving carbamazepine (CBZ) and saccharin (SAC) molecules. Supramolecular synthesis of CBZ-SAC FI and FII have been performed using thermo-kinetic methods and systematically characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), solubility and slurry measurements...
April 20, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28429838/pyrophosphate-as-substrate-for-alkaline-phosphatase-activity-a-convenient-flow-injection-chemiluminescence-assay
#6
Qingfeng Zhang, Cuiyun Zhang, Meiding Yang, Donghong Yu, Cong Yu
A sensitive and convenient flow-injection chemiluminescence (FI-CL) turn-on assay for alkaline phosphatase (ALP) activity without any label and synthesis is developed. Cu(2+) can catalyze the luminol-H2 O2 CL reaction. Pyrophosphate (PPi) can chelate Cu(2+) and therefore the Cu(2+) -mediated luminol-H2 O2 CL reaction is inhibited. The addition of ALP can catalyze the hydrolysis of PPi into phosphate ions, Cu(2+) is released and the chemiluminescence recovers. A detection limit of 1 mU/mL ALP is obtained.
April 21, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28427049/predictive-validity-of-two-physical-frailty-phenotype-specifications-developed-for-investigation-of-frailty-pathways-in-older-people
#7
Yew Yoong Ding
BACKGROUND: For investigating the relationship of frailty with physical, psychological, and social conditions on pathways, the frailty definition should ideally exclude these conditions. Based on the frailty phenotype, 2 candidate physical frailty specifications or instruments with 3 indicators, namely slowness, weakness, and exhaustion, and 4 indicators with addition of weight loss were previously developed, and had their construct and concurrent validity demonstrated. OBJECTIVE: This study seeks to evaluate the predictive validity of 2 candidate physical frailty specifications with respect to death, functional impairment, and poor quality of life in older people...
April 21, 2017: Gerontology
https://www.readbyqxmd.com/read/28426476/autologous-myoblasts-for-the-treatment-of-fecal-incontinence-results-of-a-phase-2-randomized-placebo-controlled-study-mias
#8
Olivier Boyer, Valérie Bridoux, Camille Giverne, Aurélie Bisson, Edith Koning, Anne-Marie Leroi, Pascal Chambon, Justine Déhayes, Stephanie Le Corre, Serge Jacquot, Dominique Bastit, Jérémie Martinet, Estelle Houivet, Jean-Jacques Tuech, Jacques Benichou, Francis Michot
OBJECTIVE: The aim of this study was to evaluate the efficacy of intrasphincteric injections of autologous myoblasts (AMs) in fecal incontinence (FI) in a controlled study. SUMMARY OF BACKGROUND DATA: Adult stem cell therapy is expected to definitively cure FI by regenerating damaged sphincter. Preclinical data and results of open-label trials suggest that myoblast therapy may represent a noninvasive treatment option. METHODS: We conducted a phase 2 randomized, double-blind, placebo-controlled study of intrasphincteric injections of AM in 24 patients...
April 19, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28421774/los-estudios-de-costes-herramienta-imprescindible-en-la-nutrici%C3%A3-n-cl%C3%A3-nica-del-siglo-xxi
#9
Julia Álvarez Hernández
Seguro que todos compartimos que el gasto sanitario ha crecido progresivamente año tras año en las últimas décadas. Los expertos apuntan, de una forma muy simplista, que el aumento de la demanda sanitaria (aumento de crónicas y degenerativas; envejecimiento de la población) y el incremento de costes de los elementos que comportan la oferta (avances tecnológicos) son las causas que lo provocan. También entendemos que este tipo de presión, lejos de disminuir, en un futuro próximo se prevé que seguirá en crecimiento...
March 30, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28420410/ethnopharmacologic-survey-of-medicinal-plants-used-to-treat-human-diseases-by-traditional-medical-practitioners-in-dega-damot-district-amhara-northwestern-ethiopia
#10
Muluken Wubetu, Tefera Abula, Getye Dejenu
BACKGROUND: One of the services that plants provide for human beings is their wider medicinal application. Although it is not fully assessed, the practice and wider use of traditional medicine is frequent in Ethiopia. Studies conducted previously are confined to the perceptions of modern and traditional health practitioners about traditional medicine. A total of 45 informants were selected purposefully from the study area. For collecting the data, semi-structured interviewees, observation and field walks were employed from August 10 to September 30/2014...
April 18, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28419329/effects-of-the-inclusion-of-a-bacillus-direct-fed-microbial-on-performance-parameters-bone-quality-recovered-gut-microflora-and-intestinal-morphology-in-broilers-consuming-a-grower-diet-containing-corn-distillers-dried-grains-with-solubles
#11
J D Latorre, X Hernandez-Velasco, J L Vicente, R Wolfenden, B M Hargis, G Tellez
Distillers dried grains with solubles (DDGS) have increasingly been used in poultry diets as a consequence of rising grain costs. Some, but not all, sources of DDGS have a variable compositional value, and a high inclusion of this by-product could be considered a risk factor for presentation of enteric diseases. Presently, 2 experiments were conducted using a starter corn-soybean diet (zero to 7 d) and a corn-DDGS-soybean grower diet (8 to 28 d) with or without inclusion of a Bacillus-direct-fed microbial (DFM)...
April 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28417327/influence-of-land-use-and-land-cover-on-the-spatial-variability-of-dissolved-organic-matter-in-multiple-aquatic-environments
#12
Shatrughan Singh, Padmanava Dash, Saurav Silwal, Gary Feng, Ardeshir Adeli, Robert J Moorhead
Water quality of lakes, estuaries, and coastal areas serves as an indicator of the overall health of aquatic ecosystems as well as the health of the terrestrial ecosystem that drains to the water body. Land use and land cover plays not only a significant role in controlling the quantity of the exported dissolved organic matter (DOM) but also influences the quality of DOM via various biogeochemical and biodegradation processes. We examined the characteristics and spatial distribution of DOM in five major lakes, in an estuary, and in the coastal waters of the Mississippi, USA, and investigated the influence of the land use and land cover of their watersheds on the DOM composition...
April 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28417155/pelvic-floor-symptoms-and-quality-of-life-changes-during-first-pregnancy-a-prospective-cohort-study
#13
Rebecca G Rogers, Cara Ninivaggio, Kelly Gallagher, A Noelle Borders, Clifford Qualls, Lawrence M Leeman
INTRODUCTION AND HYPOTHESIS: We describe pelvic floor function in nulliparous pregnant women. MATERIALS AND METHODS: Nulliparous midwifery patients completed the Incontinence Severity Index (ISI), Pelvic Floor Impact Questionnaire (PFIQ-7), Wexner Fecal Incontinence Scale (W), and answered questions about sexual activity and perineal pain at baseline during the first (T1), second (T2), or third trimester (T3) and repeated in late T3. They also underwent a Pelvic Organ Prolapse Quantification (POP-Q) exam at their baseline visit...
April 17, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28414342/laser-induced-thermal-lens-microscopy-for-highly-sensitive-determination-of-captopril
#14
Nader Shokoufi, Atefeh Abbasi-Ahd, Kazem Kargosha
In this work, a combined flow injection-photo thermal lens microscopy (FI-PTLM) system was used for highly sensitive determination of captopril as an angiotensin-converting enzyme inhibitor. Captopril has no absorption in the visible range, but due to its thiol group could interact with gold nanoparticles (GNPs). GNPs, because of their surface plasmon resonance (SPR), have absorption in the visible range, but their interaction with a low concentration of captopril shows no effective change in UV-Vis spectrophotometry because their aggregation is slight...
April 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/28413303/role-of-interferential-therapy-in-children-with-fecal-incontinence-postanorectal-malformation-surgeries
#15
Prince Raj, Yogesh Kumar Sarin, Prachi Raj
BACKGROUND: Anorectal malformation (ARM) is one of the most common pediatric surgical problems dealt in day-to-day practice. Although the outcome of surgery has improved a great deal over the last three decades fecal incontinence (FI) is still a common long-term morbidity that affects the quality of life of these patients. Bowel wash (BW) program with pelvic floor exercise are standard care of management for these patients. This study was undertaken to assess the role of interferential therapy (IFT) along with BW compared to BW alone in the management of FI...
April 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28413132/development-of-an-intradermal-dna-vaccine-delivery-strategy-to-achieve-single-dose-immunity-against-respiratory-syncytial-virus
#16
Trevor R F Smith, Katherine Schultheis, Matthew P Morrow, Kimberly A Kraynyak, Jay R McCoy, Kevin C Yim, Karuppiah Muthumani, Laurent Humeau, David B Weiner, Niranjan Y Sardesai, Kate E Broderick
Respiratory syncytial virus (RSV) is a massive medical burden in infants, children and the elderly worldwide, and an effective, safe RSV vaccine remains an unmet need. Here we assess a novel vaccination strategy based on the intradermal delivery of a SynCon® DNA-based vaccine encoding engineered RSV-F antigen using a surface electroporation device (SEP) to target epidermal cells, in clinically relevant experimental models. We demonstrate the ability of this strategy to elicit robust immune responses. Importantly we demonstrate complete resistance to pulmonary infection at a single low dose of vaccine in the cotton rat RSV/A challenge model...
April 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28412862/impact-of-transvaginal-hydrolaparoscopy-ovarian-drilling-on-ovarian-stromal-blood-flow-and-ovarian-volume-in-clomiphene-citrate-resistant-pcos-patients-a-case-control-study
#17
Pierluigi Giampaolino, Ilaria Morra, Nicoletta De Rosa, Angelo Cagnacci, Massimiliano Pellicano, Costantino Di Carlo, Carmine Nappi, Giuseppe Bifulco
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in gynecology. In PCOS patients vascularization parameters are altered. Transvaginal hydrolaparoscopy (THL) is a mini-invasive approach for ovarian drilling in PCOS patients. In this study, we assessed the effect of ovarian drilling using THL on ovarian volume (OV) and vascularization index (VI) using 3D power Doppler ultrasonography in CC-resistant PCOS patients. A case-control study on 123 CC-resistant PCOS women who underwent THL ovarian drilling was performed...
April 17, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28410812/cd4-t-cells-support-establishment-of-rsv-specific-igg-and-iga-antibody-secreting-cells-in-the-upper-and-lower-murine-respiratory-tract-following-rsv-infection
#18
Robert E Sealy, Sherri L Surman, Julia L Hurwitz
The RSV vaccine field suffered a major set-back when children were vaccinated with a formalin-inactivated RSV vaccine (FI-RSV). Unexpectedly, the vaccinated children fared worse than unvaccinated children when they were naturally infected with RSV. Mouse models were then developed that implicated the CD4(+) T helper cell population as a contributor to adverse events. Today, the T cell is viewed with much caution in the RSV field, and its induction by vaccination is sometimes discouraged. Here we re-emphasize the beneficial role of the CD4(+) T cell...
May 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28409499/use-of-placental-vascularization-indices-and-uterine-artery-peak-systolic-velocity-in-early-detection-of-pregnancies-complicated-by-gestational-diabetes-chronic-or-gestational-hypertension-and-preeclampsia-at-risk
#19
Ábel T Altorjay, Andrea Surányi, Tibor Nyári, Gábor Németh
AIM: We aimed to investigate correlations between uterine artery peak systolic velocity (AUtPSV), and placental vascularization in groups of normal blood pressure (NBP) and hypertensive disorders of pregnancy (chronic hypertension (CHT), gestational hypertension (GHT) and preeclampsia (PE)) alone or in combination with gestational diabetes mellitus (GDM), and hypothesized that AUtPSV rises when GDM complicates pregnancy hypertension. METHODS: Placental 3-dimensional power Doppler indices, such as vascularization index (VI), flow index (FI), and vascularization-flow index (VFI), and uterine artery peak systolic velocity (AUtPSV) were measured in CHT (N=43), CHT+GDM (N=15), GHT (N=57), GHT+GDM (N=23) and PE (N=17) pregnancies, and compared to NBP (N=109)...
April 14, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28399836/cost-effectiveness-of-response-evaluation-after-chemoradiation-in-patients-with-advanced-oropharyngeal-cancer-using-18-f-fdg-pet-ct-and-or-diffusion-weighted-mri
#20
Marjolein Je Greuter, Charlotte S Schouten, Jonas A Castelijns, Pim de Graaf, Emile Fi Comans, Otto S Hoekstra, Remco de Bree, Veerle Mh Coupé
BACKGROUND: Considerable variation exists in diagnostic tests used for local response evaluation after chemoradiation in patients with advanced oropharyngeal cancer. The yield of invasive examination under general anesthesia (EUA) with biopsies in all patients is low and it may induce substantial morbidity. We explored four response evaluation strategies to detect local residual disease in terms of diagnostic accuracy and cost-effectiveness. METHODS: We built a decision-analytic model using trial data of forty-six patients and scientific literature...
April 11, 2017: BMC Cancer
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