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Lasalocid

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https://www.readbyqxmd.com/read/27902917/coccidiosis-in-the-chukar-partridge-alectoris-chukar-a-survey-of-coccidiosis-outbreaks-and-a-test-of-anticoccidial-drugs-against-eimeria-kofoidi
#1
R W Gerhold, A L Fuller, L R McDougald
Field isolates of coccidia from 20 natural outbreaks in the chukar partridge ( Alectoris chukar ) were received from gamebird farms in 10 U.S. states. These were propagated in the laboratory and identified by microscopy and PCR. Of 20 samples, 18 were Eimeria kofoidi, two were Eimeria legionensis only, and one was a mixture of the two species. One isolate of E. kofoidi also contained an unidentified species detected only by PCR, nucleotide sequencing, and phylogenetic analysis. The efficacy of anticoccidial drugs against chukar coccidia was tested with experimental infections in battery cages...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27887889/development-of-intramammary-drug-delivery-systems-novel-in-vitro-release-method
#2
Sanjay Garg, Wen Wang, Yunmei Song, Patricia Eats, Darren J Trott, Stephen W Page, Kiro Petrovski
The aim of this study was to develop an in vitro release model for intramammary drug delivery system (IDDS) evaluation. This study was the first to establish an in vitro-in vivo correlation with investigation of IDDS containing losalocid. Three different methods including standard USP dissolution method with apparatus 2, modified USP method by using a dialysis bag or by using a specific designed enhancer cell system were assessed for the release study. Full cream milk and water were selected as the release media...
November 22, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27694977/modification-of-plant-cell-wall-structure-accompanied-by-enhancement-of-saccharification-efficiency-using-a-chemical-lasalocid-sodium
#3
Emiko Okubo-Kurihara, Misato Ohtani, Yukio Kurihara, Koichi Kakegawa, Megumi Kobayashi, Noriko Nagata, Takanori Komatsu, Jun Kikuchi, Sean Cutler, Taku Demura, Minami Matsui
The cell wall is one major determinant of plant cell morphology, and is an attractive bioresource. Here, we report a novel strategy to modify plant cell wall property by small molecules. Lasalocid sodium (LS) was isolated by chemical screening to identify molecules that affect the cell morphology of tobacco BY-2 cells. LS treatment led to an increase in cell wall thickness, whilst the quantity and sugar composition of the cell wall remained unchanged in BY-2 cells. The chemical also disordered the cellular arrangement of hypocotyls of Arabidopsis plants, resulting in a decrease in hypocotyl length...
October 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27580396/efficacy-of-treatments-with-toltrazuril-7-5-and-lasalocid-sodium-in-sheep-naturally-infected-with-eimeria-spp
#4
Fernando de Souza Rodrigues, Luiz Eduardo Roland Tavares, Fernando Paiva
The objective of this study was to evaluate the efficacy of an experimental formulation of toltrazuril 7.5% + Trimix™ on a naturally acquired infection of Eimeria spp. in suckling lambs kept on pasture and, in another trial, evaluate the comparative efficacy between lasalocid and toltrazuril 7.5% + Trimix™ in newly weaned sheep under feedlot conditions that had been naturally infected with Eimeria spp. In the first experiment, 30 suckling lambs were divided into two groups: A - treated with toltrazuril 7...
July 2016: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/27509597/evaluation-of-certain-veterinary-drug-residues-in-food-eighty-first-report-of-the-joint-fao-who-expert-committee-on-food-additives
#5
(no author information available yet)
This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues in food. The first part of the report considers general principles regarding the evaluation of residues of veterinary drugs within the terms of reference of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), including MRLs for generic fish species, acute reference doses (ARfDs) for veterinary drugs, an approach for dietary exposure assessment of compounds used for multiple purposes (i...
2016: World Health Organization Technical Report Series
https://www.readbyqxmd.com/read/27443201/a-multi-residue-method-for-17-anticoccidial-drugs-and-ractopamine-in-animal-tissues-by-liquid-chromatography-tandem-mass-spectrometry-and-time-of-flight-mass-spectrometry
#6
Johanna L Matus, Joe O Boison
A new and sensitive multi-residue liquid chromatography-tandem mass spectrometry (LC-MS/MS) and liquid chromatography-quadrupole time-of-flight-mass spectrometry (LC-QToF-MS) method was developed and validated for the determination and confirmation of residues of 17 anticoccidials, plus free ractopamine in poultry muscle and liver, and bovine muscle, liver, and kidney tissues. The 17 anticoccidials are lasalocid, halofuginone, narasin, monensin, semduramicin, ethopabate, robenidine, buquinolate, toltrazuril as its sulfone metabolite, maduramicin, salinomycin, diclazuril, amprolium, decoquinate, dinitolmide, clopidol, and the nicarbazin metabolite DNC (N,N1-bis(4-nitrophenyl)urea)...
May 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27270394/evaluation-of-ionophore-sensitivity-of-eimeria-acervulina-and-eimeria-maxima-isolated-from-the-algerian-to-jijel-province-poultry-farms
#7
Samir Djemai, Abdeslam Mekroud, Mark C Jenkins
The present study represents the first description of ionophore resistance in recovered from commercial Algerian (Jijel-Algeria) broiler farms. Microscopy and intervening transcribed sequence 1 PCR (ITS1 PCR) revealed only 2 Eimeria species present in litter from these farms- namely Eimeria acervulina and Eimeria maxima. A pool of these isolates were evaluated in broiler chickens (Cobb 500) for sensitivity to 5 anticoccidial compounds-diclazuril (1ppm), lasalocid (125ppm), monensin (125ppm), narasin (70ppm) and salinomycin (60ppm)...
July 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27189139/the-effect-of-composting-on-the-persistence-of-four-ionophores-in-dairy-manure-and-poultry-litter
#8
Osman A Arikan, Walter Mulbry, Clifford Rice
Manure composting is a well-described approach for stabilization of nutrients and reduction of pathogens and odors. Although composting studies have shown that thermophilic temperatures and aerobic conditions can increase removal rates of selected antibiotics, comparable information is lacking for many other compounds in untreated or composted manure. The objective of this study was to determine the relative effectiveness of composting conditions to reduce concentrations of four widely used ionophore feed supplements in dairy manure and poultry litter...
August 2016: Waste Management
https://www.readbyqxmd.com/read/26990733/determination-of-six-polyether-antibiotic-residues-in-foods-of-animal-origin-by-solid-phase-extraction-combined-with-liquid-chromatography-tandem-mass-spectrometry
#9
Jing Ha, Ge Song, Lian-feng Ai, Jian-Chen Li
A new method using solid phase extraction (SPE) combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed for the determination of six polyether antibiotics, including lasalocid, salinomycin, monensin, narasin, madubamycin and nigericin residues, in foods of animal origin. The samples were extracted with acetonitrile and purified by ENVI-Carb SPE columns after comparing the impurity effect and maneuverability of several SPE cartridges. Subsequently, the analytes were separated on a Hypersil Gold column (2...
April 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/26812337/a-meta-analysis-of-lasalocid-effects-on-rumen-measures-beef-and-dairy-performance-and-carcass-traits-in-cattle
#10
H M Golder, I J Lean
The effects of lasalocid on rumen measures, beef and dairy performance, and carcass traits were evaluated using meta-analysis. Meta-regression was used to investigate sources of heterogeneity. Ten studies (20 comparisons) were used in the meta-analysis on rumen measures. Lasalocid increased total VFA and ammonia concentrations by 6.46 and 1.44 m, respectively. Lasalocid increased propionate and decreased acetate and butyrate molar percentage (M%) by 4.62, 3.18, and 0.83%, respectively. Valerate M% and pH were not affected...
January 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/26593474/validation-of-a-liquid-chromatography-electrospray-ionization-tandem-mass-spectrometric-method-to-determine-six-polyether-ionophores-in-raw-uht-pasteurized-and-powdered-milk
#11
Mararlene Ulberg Pereira, Bernardete Ferraz Spisso, Silvana do Couto Jacob, Mychelle Alves Monteiro, Rosana Gomes Ferreira, Betânia de Souza Carlos, Armi Wanderley da Nóbrega
This study aimed to validate a method developed for the determination of six antibiotics from the polyether ionophore class (lasalocid, maduramicin, monensin, narasin, salinomycin and semduramicin) at residue levels in raw, UHT, pasteurized and powdered milk using QuEChERS extraction and high performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS). The validation was conducted under an in-house laboratory protocol that is primarily based on 2002/657/EC Decision, but takes in account the variability of matrix sources...
April 1, 2016: Food Chemistry
https://www.readbyqxmd.com/read/26374291/thermorudis-pharmacophila-sp-nov-a-novel-member-of-the-class-thermomicrobia-isolated-from-geothermal-soil-and-emended-descriptions-of-thermomicrobium-roseum-thermomicrobium-carboxidum-thermorudis-peleae-and-sphaerobacter-thermophilus
#12
Karen M Houghton, Xochitl C Morgan, Kirill Lagutin, Andrew D MacKenzie, Mikhail Vyssotskii, Kevin A Mitchell, Ian R McDonald, Hugh W Morgan, Jean F Power, John W Moreau, Eric Hanssen, Matthew B Stott
An aerobic, thermophilic and cellulolytic bacterium, designated strain WKT50.2T, was isolated from geothermal soil at Waikite, New Zealand. Strain WKT50.2T grew at 53-76 °C and at pH 5.9-8.2. The DNA G+C content was 58.4 mol%. The major fatty acids were 12-methyl C18 : 0 and C18 : 0. Polar lipids were all linked to long-chain 1,2-diols, and comprised 2-acylalkyldiol-1-O-phosphoinositol (diolPI), 2-acylalkyldiol-1-O-phosphoacylmannoside (diolP-acylMan), 2-acylalkyldiol-1-O-phosphoinositol acylmannoside (diolPI-acylMan) and 2-acylalkyldiol-1-O-phosphoinositol mannoside (diolPI-Man)...
December 2015: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/26093967/spectroscopic-studies-of-the-equilibrium-between-complexes-of-lasalocid-acid-with-propargylamine-and-metal-cations
#13
Jacek Rutkowski, Adam Huczyński, Małgorzata Ratajczak-Sitarz, Andrzej Katrusiak, Bogumil Brzezinski, Franz Bartl
The molecular structure of 1:1 complex formed between the naturally occurring polyether ionophore, called lasalocid acid (LAS) and propargylamine (PROP) is studied by X-ray, FT-IR, (1)H NMR, (13)C NMR and ESI-MS methods. The complex formed between deprotonated LAS acid and protonated PROP molecule is stabilized by intra- and inter-molecular hydrogen bonds. The protons of the protonated amine group are hydrogen bonded to etheric and hydroxyl oxygen atoms of the LAS anion. The similarity of the FT-IR spectra of the LAS-PROP complex in solid state and in solution demonstrated that the molecular structures of the complex in both states are comparable...
2015: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/26054429/analysis-of-lasalocid-residues-in-grease-and-fat-using-liquid-chromatography-mass-spectrometry
#14
Susan B Clark, Joseph M Storey, Justin R Carr, Mark Madson
A method for the determination of lasalocid, an antibiotic and coccidiostat, in grease and fat is described. The manufacture of lasalocid produces a grease-like residue as a waste byproduct. Recently this byproduct has been shown to have been illegally introduced into the animal feed chain. Therefore, a quantitative and confirmatory procedure to analyse for lasalocid in this matrix is needed. A portion of grease/oil sample was extracted into hexane-washed acetonitrile, and a portion of the extract was then applied to a carboxylic acid solid-phase extraction (SPE) column for concentration and clean-up...
2015: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/25958138/determination-of-fifteen-coccidiostats-in-feed-at-carry-over-levels-using-liquid-chromatography-mass-spectrometry
#15
Konrad Pietruk, Małgorzata Olejnik, Piotr Jedziniak, Teresa Szprengier-Juszkiewicz
A multi-residue method has been developed and validated for the simultaneous determination of authorized (decoquinate, diclazuril, halofuginone, lasalocid, maduramicin, monensin, narasin, nicarbazin, robenidine, salinomycin and semduramicin) and non-authorized (amprolium, clopidol, ethopabate and toltrazuril) coccidiostats in animal feed. Feed samples were extracted with basic followed by acidified solution in methanol and, after centrifugation, were injected directly into LC-MS/MS system. Detection was performed in selected reaction monitoring mode with both positive and negative electrospray ionization...
August 10, 2015: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/25888186/biochemical-and-genetic-diversity-of-carbohydrate-fermenting-and-obligate-amino-acid-fermenting-hyper-ammonia-producing-bacteria-from-nellore-steers-fed-tropical-forages-and-supplemented-with-casein
#16
Cláudia Braga Pereira Bento, Analice Cláudia de Azevedo, Edenio Detmann, Hilário Cuquetto Mantovani
BACKGROUND: Dietary protein plays a major role in ruminant nutrition, and protein supplementation is a widespread practice among farmers in the tropics. Ruminal bacteria are the main agents of dietary protein and amino acid degradation, yet few studies have focused on the isolation and characterization of hyper-ammonia-producing bacteria in animals fed tropical diets or supplemented with rumen-degradable proteins. This work investigated the bacterial community diversity of the rumen of Nellore steers fed tropical forages, with or without casein supplementation...
2015: BMC Microbiology
https://www.readbyqxmd.com/read/25777011/biochemical-and-genetic-diversity-of-carbohydrate-fermenting-and-obligate-amino-acid-fermenting-hyper-ammonia-producing-bacteria-from-nellore-steers-fed-tropical-forages-and-supplemented-with-casein
#17
Cláudia Braga Pereira Bento, Analice Cláudia de Azevedo, Edenio Detmann, Hilário Cuquetto Mantovani
BACKGROUND: Dietary protein plays a major role in ruminant nutrition, and protein supplementation is a widespread practice among farmers in the tropics. Ruminal bacteria are the main agents of dietary protein and amino acid degradation, yet few studies have focused on the isolation and characterization of hyper-ammonia-producing bacteria in animals fed tropical diets or supplemented with rumen-degradable proteins. This work investigated the bacterial community diversity of the rumen of Nellore steers fed tropical forages, with or without casein supplementation...
December 2015: BMC Microbiology
https://www.readbyqxmd.com/read/25773180/combination-of-cell-culture-and-qpcr-to-assess-the-efficacy-of-different-anticoccidials-on-eimeria-tenella-sporozoites
#18
Ahmed Thabet, Alaa Aldin Alnassan, Arwid Daugschies, Berit Bangoura
Three in vitro studies were designed to develop an assay for anticoccidial efficacy by use of laboratory (Houghton) and field (T-376) Eimeria tenella strains. In study (1), minimum inhibitory concentrations (MICs) of monensin (Mon), maduramicin (Mad), salinomycin (Sal), and lasalocid (Las) were determined that are able to inhibit more than 50% of sporozoites in host cell (Madin-Darby bovine kidney (MDBK)) penetration and more than 95% of Houghton sporozoites development to mature merozoites (treatment time 24 h) using quantitative real-time PCR (qPCR)...
June 2015: Parasitology Research
https://www.readbyqxmd.com/read/25683430/development-and-validation-of-a-liquid-chromatographic-tandem-mass-spectrometric-method-for-determination-of-eleven-coccidiostats-in-milk
#19
Szilárd Nász, Lajos Debreczeni, Tamás Rikker, Zsuzsanna Eke
A reversed phase liquid chromatographic-tandem mass spectrometric method with simple solvent extraction and purification by solid phase extraction (SPE) has been developed for the determination of coccidiostats in milk. For sample preparation matrix solid phase dispersion, extraction by organic solvent and SPE with different cartridges were also tested. The compounds determined include lasalocid, narasin, salinomycin, monensin, semduramicin, maduramicin, robenidine, decoquinate, halofuginone, nicarbazin and diclazuril...
July 15, 2012: Food Chemistry
https://www.readbyqxmd.com/read/25653501/development-of-intramammary-delivery-systems-containing-lasalocid-for-the-treatment-of-bovine-mastitis-impact-of-solubility-improvement-on-safety-efficacy-and-milk-distribution-in-dairy-cattle
#20
COMPARATIVE STUDY
Wen Wang, Yunmei Song, Kiro Petrovski, Patricia Eats, Darren J Trott, Hui San Wong, Stephen W Page, Jeanette Perry, Sanjay Garg
BACKGROUND: Mastitis is a major disease of dairy cattle. Given the recent emergence of methicillin-resistant Staphylococcus aureus as a cause of bovine mastitis, new intramammary (IMA) treatments are urgently required. Lasalocid, a member of the polyether ionophore class of antimicrobial agents, has not been previously administered to cows by the IMA route and has favorable characteristics for development as a mastitis treatment. This study aimed to develop an IMA drug delivery system (IMDS) of lasalocid for the treatment of bovine mastitis...
2015: Drug Design, Development and Therapy
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