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https://www.readbyqxmd.com/read/29452603/the-effects-of-desflurane-and-sevoflurane-on-nesfatin-1-levels-in-laparoscopic-cholecystectomy-a-randomized-controlled-trial
#1
A T D Ozcan, C B Altin, S Erdogan, M Ergin, A Çiftçi, H Kara, S M Aksoy, A But
BACKGROUND: Nesfatin-1 is involved in cardiovascular regulation, stress-related responses. The objective of this study is to investigate the impact of volatile anesthetics on Nesfatin-1 levels. METHOD: Fourty-two patients aged 30-65 years with the American Society Anesthesiology (ASA) Class I-II who were scheduled for laparoscopic cholecystectomy were included in the study Patients were randomized into two group; desflurane administered group (Group I, n = 21) and sevoflurane administered group (Group II, n = 21)...
February 16, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29451141/associations-between-body-composition-indices-and-metabolic-disorders-in-chinese-adults-a-cross-sectional-observational-study
#2
Rong Zhang, Sheng-Yong Dong, Fei Wang, Cong Ma, Xiao-Lan Zhao, Qiang Zeng, Ao Fei
Background: Obesity induces dyslipidemia, hypertension, glucose intolerance, and inflammatory state, which results in atherogenic processes, diabetes, and cardiovascular disease. We usually use body composition indices, such as body mass index (BMI), body fat percentage (BFP), waist circumference-height ratio (WHtR), and waist-hip ratio (WHR) to reflect the obesity. The aim of this large population-based cross-sectional study was to investigate the associations between body composition indices and metabolic parameters in Chinese adults...
February 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29449705/comparison-between-l-type-and-n-l-type-calcium-channel-blockers-in-the-regulation-of-home-blood-pressure-variability-in-elderly-hypertensive-patients
#3
Satoko Nozato, Koichi Yamamoto, Yoichi Nozato, Masao Takeda, Kazuhiro Hongyo, Miyuki Takeya, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Norihisa Ito, Hiromi Rakugi
Recent studies suggest that L-type calcium channel blockers (CCBs) contribute to reducing blood pressure (BP) variability. We investigated whether inhibition of the N-type calcium channel has an additional effect on BP variability by comparing the effect of L-type and L/N-type CCBs on home BP variability in elderly hypertensive patients. Twenty-six hypertensive patients (≥65 years) were subjected to repeated changes with the administration of amlodipine (L-type CCB) and cilnidipine (L/N-type CCB) every 2 months...
February 15, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29449333/endothelial-cell-autonomous-role-of-akt1-regulation-of-vascular-tone-and-ischemia-induced-arteriogenesis
#4
Monica Y Lee, Ana Gamez-Mendez, Jiasheng Zhang, Zhenwu Zhuang, David J Vinyard, Jan Kraehling, Heino Velazquez, Gary W Brudvig, Themis R Kyriakides, Michael Simons, William C Sessa
OBJECTIVE: The importance of PI3K/Akt signaling in the vasculature has been demonstrated in several models, as global loss of Akt1 results in impaired postnatal ischemia- and VEGF-induced angiogenesis. The ubiquitous expression of Akt1, however, raises the possibility of cell-type-dependent Akt1-driven actions, thereby necessitating tissue-specific characterization. APPROACH AND RESULTS: Herein, we used an inducible, endothelial-specific Akt1-deleted adult mouse model (Akt1iECKO) to characterize the endothelial cell autonomous functions of Akt1 in the vascular system...
February 15, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29448283/-significance-of-endothelin-1-in-glaucoma-a-short-overview
#5
Konstantin Gugleta
This review article is focused on the various facets of possible endothelin's role in glaucoma; involvement of endothelin in other ocular, in particular vascular, diseases is not specifically discussed. Endothelin is an ubiquitous molecule that occurs in practically all ocular tissues. Its primary physiological function is regulation of the blood vessel diameter and hence regulation of the blood supply in tissues. It is secreted locally, and exerts its effect also predominantly locally. This limits the value of venous blood sampling for estimation of the endothelin function in a particular patient, or in study cohorts as well...
February 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29448245/a-genetic-variant-associated-with-the-five-vascular-diseases-is-a-distal-regulator-of-endothelin-1-gene-expression
#6
Ernesto L Schiffrin
Gupta et al. [Cell 2017; 170: 522-533] have shown that a genetic variant associated with the 5 vascular diseases is a distal regulator of endothelin (ET)-1 gene (EDN1) expression. A common single nucleotide polymorphism (SNP) in the third intron of the PHACTR1 gene, rs9349379, is the potential variant responsible for increased risk of coronary artery disease, and lower risk of migraine, carotid dissection, fibromuscular dysplasia, and hypertension. Since ET-1 acts through ET type B receptors (ETBR) on endothelial cells to stimulate the production of nitric oxide and prostacyclin and induce vasodilation, this may contribute to these findings...
February 15, 2018: Nephron
https://www.readbyqxmd.com/read/29445943/impact-of-the-clinical-use-of-rock-inhibitor-on-the-pathogenesis-and-treatment-of-glaucoma
#7
REVIEW
Megumi Honjo, Hidenobu Tanihara
Rho-associated protein kinase (ROCK), a ubiquitously expressed signaling messenger and downstream effector of Rho, is activated by several bioactive factors in the aqueous humor (AH). Rho-ROCK signaling regulates a wide spectrum of fundamental cellular events, including cell adhesion, motility, proliferation, differentiation, and apoptosis. Previous studies, including our own, found that ROCK inhibitor lowers intraocular pressure (IOP) via a direct effect on the conventional AH outflow pathway, by regulation of contractile properties, fibrotic activity, and permeability of the trabecular meshwork (TM) and Schlemm's canal (SC) tissues, influencing extracellular matrix (ECM) production...
February 14, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29442548/mechanisms-of-altered-renal-sodium-handling-in-age-related-hypertension
#8
Alissa A Frame, Richard David Wainford
The prevalence of hypertension rises with age to approximately two out of three adults over the age of 60 in the United States. Although the mechanisms underlying age-related hypertension are incompletely understood, sodium homeostasis is critical to the long-term regulation of blood pressure and there is strong evidence that aging is associated with alterations in renal sodium handling. This mini-review focuses on recent advancements in our understanding of the vascular, neurohumoral, and renal mechanisms that influence sodium homeostasis and promote age-related hypertension...
February 14, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29438673/distribution-of-nitric-oxide-synthase-in-the-rock-cavy-kerodon-rupestris-brain-i-the-diencephalon
#9
Maria Emanuela Martins Dos Reis, Lucimário Thiago Félix de Araújo, Wylqui Mikael Gomes de Andrade, Nayra da Silva Resende, Ruthnaldo Rodrigues Melo de Lima, Expedito Silva do Nascimento, Miriam Stela Maris de Oliveira Costa, Judney Cley Cavalcante
Nitric oxide (NO) is a highly soluble and membrane-permeable neurotransmitter, so it does not need to be packed in vesicles or have a membrane receptor. In the nervous system, NO is synthesized by the neuronal form of the nitric oxide synthase (NOS) enzyme and has been considered as a local neurotransmitter. NOS distribution is widespread in the nervous system of various vertebrate species, which may explain its participation in many functions such as memory, blood pressure regulation and sexual behavior. Here we used immunohistochemistry against NOS and NADPH diaphorase histochemistry to map the distribution of NO in the diencephalon of the rock cavy (Kerodon rupestris), a rodent endemic to the Brazilian Northeast...
February 10, 2018: Brain Research
https://www.readbyqxmd.com/read/29437897/tlr9-toll-like-receptor-9-agonist-suppresses-angiogenesis-by-differentially-regulating-vegfa-vascular-endothelial-growth-factor-a-and-sflt1-soluble-vascular-endothelial-growth-factor-receptor-1-in-preeclampsia
#10
Biwei He, Xingyu Yang, Yamei Li, Ding Huang, Xin Xu, Wenjun Yang, Yan Dai, Huijuan Zhang, Zhengjun Chen, Weiwei Cheng
Preeclampsia is a common pregnancy-specific disorder characterized by elevated blood pressure and proteinuria. Activation of the maternal immune system and impaired placental angiogenesis are thought to contribute to the pathogenesis of preeclampsia. TLR9 (Toll-like receptor 9) plays a role in innate immunity, defending the organism against infection. The purpose of this study was to determine whether TLR9 inhibits angiogenesis at the fetomaternal interface under conditions of preeclampsia. We confirmed the downregulation of VEGFA (vascular endothelial growth factor A) and upregulation of TLR9 and sFLT1 (soluble vascular endothelial growth factor receptor 1) in placentas from preeclamptic women...
February 5, 2018: Hypertension
https://www.readbyqxmd.com/read/29433732/inhibition-of-marfan-syndrome-aortic-root-dilation-by-losartan-role-of-angiotensin-ii-receptor-type-1-independent-activation-of-endothelial-function
#11
Stephanie L Sellers, Nadia Milad, Rayleigh Chan, Michael Mielnik, Una Jermilova, Paul L Huang, Rini de Crom, Jeremy A Hirota, James C Hogg, George G Sandor, Casey Van Breemen, Mitra Esfandiarei, Michael A Seidman, Pascal Bernatchez
Marfan syndrome (MFS) is a genetic disorder that frequently leads to aortic root dissection and aneurysm. Despite promising preclinical and pilot clinical data, a recent large-scale study using antihypertensive angiotensin II (AngII) receptor type 1 (ATR1) blocker losartan has failed to meet expectations at preventing MFS-associated aortic root dilation, casting doubts about optimal therapy. To study the deleterious role of normal ATR1 signaling in aortic root widening, we generated MFS mice lacking ATR1a expression in an attempt to preserve protective ATR2 signaling...
February 3, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29432887/role-of-brain-neuroinflammatory-factors-on-hypertension-in-the-spontaneously-hypertensive-rat
#12
Ennio Avolio, Teresa Pasqua, Anna Di Vito, Gilda Fazzari, Gabriella Cardillo, Raffaella Alò, Maria Carmela Cerra, Tullio Barni, Tommaso Angelone, Marcello Canonaco
It is already widely known that the different brain areas involved in blood pressure control, are highly vulnerable to the deleterious effects of this condition. Of particular concern are hypertensive and neuroinflammatory-dependent injuries that by modifying blood flow account for artery structural and functional alterations. It was thus our intention to establish if expression changes of some key brain neuroinflammatory factors like caspase-1,3, NF-kB, IL-1β and NLRP3, which are known to control blood pressure, are actively involved with inflammation regulatoryevents in a highly valuable spontaneously hypertensive rat (SHR) model...
February 9, 2018: Neuroscience
https://www.readbyqxmd.com/read/29430077/hypoxia-inducible-factor-1%C3%AE-in-antarctic-notothenioids-contains-a-polyglutamine-and-glutamic-acid-insert-that-varies-in-length-with-phylogeny
#13
A S Rix, T J Grove, K M O'Brien
The long evolution of the Antarctic perciform suborder of Notothenioidei in the icy, oxygen-rich waters of the Southern Ocean may have reduced selective pressure to maintain a hypoxic response. To test this hypothesis, cDNA of the key transcriptional regulator of hypoxic genes, hypoxia-inducible factor-1α (HIF-1α), was sequenced in heart ventricles of the red-blooded notothenioid, Notothenia coriiceps, and the hemoglobinless icefish, Chaenocephalus aceratus. HIF-1α cDNA is 4500 base pairs (bp) long and encodes 755 amino acids in N...
December 2017: Polar Biology
https://www.readbyqxmd.com/read/29429026/modulation-of-renal-sympathetic-innervation-recent-insights-beyond-blood-pressure-control
#14
REVIEW
Dominik Linz, Mathias Hohl, Adrian D Elliott, Dennis H Lau, Felix Mahfoud, Murray D Esler, Prashanthan Sanders, Michael Böhm
Renal afferent and efferent sympathetic nerves are involved in the regulation of blood pressure and have a pathophysiological role in hypertension. Additionally, several conditions that frequently coexist with hypertension, such as heart failure, obstructive sleep apnea, atrial fibrillation, renal dysfunction, and metabolic syndrome, demonstrate enhanced sympathetic activity. Renal denervation (RDN) is an approach to reduce renal and whole body sympathetic activation. Experimental models indicate that RDN has the potential to lower blood pressure and prevent cardio-renal remodeling in chronic diseases associated with enhanced sympathetic activation...
February 10, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29428638/elevated-20-hete-in-metabolic-syndrome-regulates-arterial-stiffness-and-systolic-hypertension-via-mmp12-activation
#15
Amanda Soler, Ian Hunter, Gregory Joseph, Rebecca Hutcheson, Brenda Hutcheson, Jenny Yang, Frank Fan Zhang, Sachindra Raj Joshi, Chastity Bradford, Katherine H Gotlinger, Rachana Maniyar, John R Falck, Spencer Proctor, Michal Laniado Schwartzman, Sachin A Gupte, Petra Rocic
Arterial stiffness plays a causal role in development of systolic hypertension. 20-hydroxyeicosatetraeonic acid (20-HETE), a cytochrome P450 (CYP450)-derived arachidonic acid metabolite, is known to be elevated in resistance arteries in hypertensive animal models and loosely associated with obesity in humans. However, the role of 20-HETE in the regulation of large artery remodeling in metabolic syndrome has not been investigated. We hypothesized that elevated 20-HETE in metabolic syndrome increases matrix metalloproteinase 12 (MMP12) activation leading to increased degradation of elastin, increased large artery stiffness and increased systolic blood pressure...
February 8, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29425800/influence-of-the-selective-cox-2-inhibitor-celecoxib-on-sex-differences-in-blood-pressure-and-albuminuria-in-spontaneously-hypertensive-rats
#16
Ahmed A Elmarakby, Mohamed Katary, Jennifer S Pollock, Jennifer C Sullivan
We previously reported that female spontaneously hypertensive rats (SHR) have greater cyclooxygenase-2 (COX-2) expression in the renal medulla and enhanced urinary excretion of prostaglandin (PG) E2 (PGE2) metabolites compared to male SHR. Based on the role of COX-2-derived prostanoids in the regulation of cardiovascular health, the aim of the current study was to test the hypothesis that blood pressure (BP) in female SHR is more sensitive to COX-2 inhibition than in males. Seven week old male and female SHR were implanted with telemetry transmitters for continuous BP recording...
February 6, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29425281/at1-receptor-antagonism-improves-structural-functional-and-biomechanical-properties-in-resistance-arteries-in-a-rodent-chronic-kidney-disease-model
#17
K J Quek, O Z Ameer, J K Phillips
Background: The renin-angiotensin system, in particular Angiotensin II (AngII), plays a significant role in the pathogenesis of hypertension in chronic kidney disease (CKD). Effects of chronic AT1 receptor antagonism were investigated in a genetic hypertensive rat model of CKD, the Lewis polycystic kidney (LPK) rat. Methods: Mixed-sex LPK and Lewis control rats (total n=31) were split between treated (valsartan 60mg/kg/day p.o. from 4-18 weeks) and vehicle groups...
February 7, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29417469/association-between-systemic-leptin-and-neurotensin-concentration-in-adult-individuals-with-and-without-type-2-diabetes-mellitus
#18
I Barchetta, G Ciccarelli, F A Cimini, V Ceccarelli, M Orho-Melander, O Melander, M G Cavallo
PURPOSE: Leptin is an adipokine which regulates appetite and energy balance through a mechanism partially mediated by neurotensin (NT) in central nervous system. Besides acting as a neurotransmitter, NT is expressed in human intestine where it promotes fat absorption and its circulating levels associate with obesity, type 2 diabetes mellitus (T2DM) and cardiovascular disease. Whether a relation exists between circulating leptin and NT levels has not been investigated yet. The aim of this study was to test the hypothesis of an association between plasma leptin and NT concentration in adults with or without T2DM...
February 7, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29416211/cardiovascular-risk-factors-in-patients-with-poorly-controlled-diabetes-mellitus
#19
Amela Dizdarevic-Bostandzic, Ermin Begovic, Azra Burekovic, Zelija Velija-Asimi, Amina Godinjak, Vanja Karlovic
Introduction: Diabetes mellitus(DM) is considered an independent cardiovascular risk factor. Having in mind concomitant occurence of diabetes and other cardiovascular risk factors, it is expected that patients with poor glucoregulation will have more cardiovascular risk factors and higher cardiovascular risk than patients with good glucoregulation. Aim: To compare cardiovascular risk and cardiovascular risk factors between patients with poorly controlled and patients with well-controlled Diabetes mellitus...
February 2018: Medical Archives
https://www.readbyqxmd.com/read/29416109/atp2b1-gene-silencing-increases-no-production-under-basal-conditions-through-the-ca2-calmodulin-enos-signaling-pathway-in-endothelial-cells
#20
Yang Long, Shao-Wei Chen, Chen-Lin Gao, Xue-Mei He, Guan-Nan Liang, Jian Wu, Chun-Xia Jiang, Xin Liu, Fang Wang, Feng Chen
Emerging epidemiological and experimental evidence has shown that the ATP2B1 gene is associated with blood pressure control. Impaired eNOS activity and NO production may be among the mechanisms involved. However, little is known about how PMCA1, which is encoded by the ATP2B1 gene, regulates the activity of eNOS and NO production. In the present study, we investigated the role of the ATP2B1 gene in regulating eNOS activity and NO production under basal conditions in HUVECs and explored the mechanisms involved...
February 7, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
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