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Endstage renal disease

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https://www.readbyqxmd.com/read/27784272/rationale-and-study-design-of-the-prospective-longitudinal-observational-cohort-study-risk-stratification-in-end-stage-renal-disease-isar-study
#1
Christoph Schmaderer, Susanne Tholen, Anna-Lena Hasenau, Christine Hauser, Yana Suttmann, Siegfried Wassertheurer, Christopher C Mayer, Axel Bauer, Kostantinos D Rizas, Stephan Kemmner, Konstantin Kotliar, Bernhard Haller, Johannes Mann, Lutz Renders, Uwe Heemann, Marcus Baumann
BACKGROUND: The ISAR study is a prospective, longitudinal, observational cohort study to improve the cardiovascular risk stratification in endstage renal disease (ESRD). The major goal is to characterize the cardiovascular phenotype of the study subjects, namely alterations in micro- and macrocirculation and to determine autonomic function. METHODS/DESIGN: We intend to recruit 500 prevalent dialysis patients in 17 centers in Munich and the surrounding area. Baseline examinations include: (1) biochemistry, (2) 24-h Holter Electrocardiography (ECG) recordings, (3) 24-h ambulatory blood pressure measurement (ABPM), (4) 24 h pulse wave analysis (PWA) and pulse wave velocity (PWV), (5) retinal vessel analysis (RVA) and (6) neurocognitive testing...
October 26, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27642745/-posttransplantation-diabetes-mellitus-in-patients-after-kidney-transplantation-incidence-and-risk-factors
#2
Isabell Jahn, Martin Busch, Undine Ott, Gunter Wolf, Wilgard Battefeld
BACKGROUND: Transplantation (NTX) associated ischemia-reperfusion-mechanisms and the predisposition for insulin resistance are discussed as causes of a posttransplantation diabetes mellitus (PTDM). Furthermore, immunosuppressants can have a damaging effect on insulin secretion. METHODS: 55 metabolically healthy patients with an endstage renal disease (age 52 ± 14 years, body mass index 27 ± 5 kg / m(2), blood pressure 137 ± 15/82 ± 11 mmHg) were included in a prospectively cohort study...
September 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27585688/treatments-for-lupus-nephritis-a-systematic-review-and-network-metaanalysis
#3
Jasvinder A Singh, Alomgir Hossain, Ahmed Kotb, Ana Oliveira, Amy S Mudano, Jennifer Grossman, Kevin Winthrop, George A Wells
OBJECTIVE: To compare benefits and harms of lupus nephritis (LN) induction and maintenance treatments. METHODS: We performed a systematic review and Bayesian network metaanalyses of randomized controlled trials (RCT) of immunosuppressive drugs or corticosteroids (CS) in LN. OR and 95% credible intervals (CrI) were calculated. RESULTS: There were 65 RCT that met inclusion and exclusion criteria. Significantly lower risk of endstage renal disease (ESRD; 17 studies) was seen with cyclophosphamide (CYC; OR 0...
October 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27424686/pentraxin-3-in-hemodialysis-patients-relationship-to-comorbidities
#4
Aziza Ahmed El Sebai, Eman Saleh El Hadidi, Hala Abdel Al, Engy Yousry El Sayed
Hemodialysis (HD), despite being the most common treatment modality for endstage renal disease (ESRD), still carries a mortality rate higher than 20-50%/year resulting from various comorbidities. The aim of this study was to measure the plasma level of pentraxin-3 (PTX-3) in patients on maintenance HD and to assess its relationships to comorbidities such as malnutrition and associated comorbid diseases. This case-control study included 50 HD patients, 30 ESRD patients, and 30 healthy controls. HD patients were classified into different subgroups according to the Davies comorbidity index and malnutrition score...
July 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27210264/empa-reg-and-other-cardiovascular-outcome-trials-of-glucose-lowering-agents-implications-for-future-treatment-strategies-in-type-2-diabetes-mellitus
#5
Guntram Schernthaner, Marie Helene Schernthaner-Reiter, Gerit-Holger Schernthaner
During the last decade, the armamentarium for glucose-lowering drugs has increased enormously by the development of DPP-4 inhibitors, GLP-1 receptor agonists and SGLT2 inhibitors, allowing individualization of antidiabetic therapy for patients with type 2 diabetes (T2DM). Some combinations can now be used without an increased risk for severe hypoglycemia and weight gain. Following a request of the US Food and Drug Administration, many large cardiovascular (CV) outcome studies have been performed in patients with longstanding disease and established CV disease...
June 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/26925249/establishing-a-continuum-of-acute-kidney-injury-tracing-aki-using-data-source-linkage-and-long-term-follow-up-workgroup-statements-from-the-15th-adqi-consensus-conference
#6
Ravindra Mehta, Azra Bihorac, Nicholas M Selby, Hude Quan, Stuart L Goldstein, John A Kellum, Claudio Ronco, Sean M Bagshaw
BACKGROUND: Acute kidney injury (AKI) is independently associated with the development of chronic kidney disease, endstage kidney disease and increased all-cause and cardiovascular-specific mortality. The severity of the renal insult and the development of multiple AKI episodes increase the risk of occurrence of these outcomes. Despite these long-term effects, only a minority of patients receive nephrologist follow up after an episode of AKI; those that do may have improved outcomes. Furthermore, relatively simple quality improvement strategies have the potential to change this status quo...
2016: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/26529978/-kidney-disease-and-laboratory-examinations-opening-remarks-for-better-understanding-of-ckd
#7
Haruyoshi Yoshida, Takashi Wada
Chronic kidney diseases (CKD) have been cited as major risk factors not only for endstage renal failure, but also for the development of cardiovascular diseases and death. In the former criteria for CKD diagnosis (NKF K/DOQI, 2002), estimation of the severity of CKD was simply based on GFR, in order for it to be widely and easily understood by general physicians and patients. Therefore, the use of the CKD guideline without information on the causes and grades of albuminuria was limited for estimation of the prognosis...
February 2015: Rinsho Byori. the Japanese Journal of Clinical Pathology
https://www.readbyqxmd.com/read/26486355/death-end-stage-renal-disease-and-renal-function-decline-in-patients-with-diabetic-nephropathy-in-french-cohorts-of-type-1-and-type-2-diabetes
#8
Samy Hadjadj, Bertrand Cariou, Frederic Fumeron, Elise Gand, Guillaume Charpentier, Ronan Roussel, Ahmed-Amine Kasmi, Jean-François Gautier, Kammel Mohammedi, Pierre Gourdy, Pierre-Jean Saulnier, Eva Feigerlova, Michel Marre
AIMS/HYPOTHESIS: Microvascular complications are a common feature of diabetes but additional research is needed regarding diabetic nephropathy endpoints in type 1 and type 2 diabetes. METHODS: We compared 277 type 1 diabetes patients with 942 type 2 diabetes patients, with clinical proteinuria and no endstage renal disease (ESRD) at baseline, prospectively followed for death, ESRD and decline in estimated glomerular filtration rate (eGFR, all available measures)...
January 2016: Diabetologia
https://www.readbyqxmd.com/read/26373566/comparison-of-lupus-nephritis-induction-treatments-in-a-hispanic-population-a-single-center-cohort-analysis
#9
COMPARATIVE STUDY
Juan Manuel Mejía-Vilet, José Manuel Arreola-Guerra, Bertha M Córdova-Sánchez, Luis Eduardo Morales-Buenrostro, Norma O Uribe-Uribe, Ricardo Correa-Rotter
OBJECTIVE: To evaluate response rates in an adult lupus nephritis (LN) cohort in Mexico City, Mexico. METHODS: We analyzed 165 patients with biopsy-proven LN histological International Society of Nephrology/Renal Pathology Society classes III, IV, or V, distributed by treatment drug in 3 groups: mycophenolate mofetil (MMF; dosage > 2 g/day per 6 mos, n = 63), intravenous cyclophosphamide (IVC; 0.7 g/m(2) body surface area monthly per 6 pulses, n = 66), or azathioprine (AZA; dosage > 1...
November 2015: Journal of Rheumatology
https://www.readbyqxmd.com/read/26354591/spectrum-of-iga-nephropathy-in-a-single-center
#10
Uttara Das, Kaligotla Venkata Dakshinamurty, Aruna Prayaga, Megha Uppin
Immunoglobulin A (IgA) nephropathy (IgAN) is the most common biopsy-proven primary glomerular disease in the world and a major contributor to the worldwide burden of endstage renal failure, with a wide geographical variation. To determine the incidence, clinical profile and histological pattern of IgAN in our institute, we reviewed all the patients who had native kidney biopsies with the diagnosis of primary IgAN during the period from 1998 to 2009 in the context of the clinical features. A total of 116 patients with IgAN were finally analyzed; 85 (73%) of the patients were male, the mean age of the patients was 29...
September 2015: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/26152402/effects-of-blood-pressure-on-renal-and-cardiovascular-outcomes-in-asian-patients-with-type-2-diabetes-and-overt-nephropathy-a-post-hoc-analysis-orient-blood-pressure
#11
MULTICENTER STUDY
Enyu Imai, Sadayoshi Ito, Masakazu Haneda, Atsushi Harada, Fumiaki Kobayashi, Tetsu Yamasaki, Hirofumi Makino, Juliana C N Chan
BACKGROUND: Blood pressure (BP) control may have different effects on cardiovascular (CV) and renal outcomes in diabetes. We examined the impact of systolic BP (SBP) on renal and CV outcomes in a post hoc analysis in the Olmesartan Reducing Incidence of Endstage Renal Disease in Diabetic Nephropathy Trial. METHODS: We stratified mean follow-up SBP into three categories (≤130, 131-140 and >140 mmHg) and used a Cox regression model to estimate the hazard ratio (HR, 95% confidence interval) for the outcomes...
March 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26082272/pentoxifylline-decreases-dialysis-risk-in-patients-with-advanced-chronic-kidney-disease
#12
COMPARATIVE STUDY
P-C Wu, C-J Wu, C-J Lin, C-F Pan, C-Y Chen, T-M Huang, C-H Wu, S-L Lin, Y-M Chen, L Chen, V-C Wu
Few studies evaluated the effects of pentoxifylline on hard endpoints in patients with predialysis stage 5 chronic kidney disease (CKD). Thus, we tried to explore the effects of pentoxifylline and its interaction with renin-angiotensin-aldosterone system (RAAS) blockade on the development of endstage renal disease (ESRD) and mortality. This nationwide cohort study retrospectively included patients who had a serum creatinine level of >6 mg/dL and received erythropoiesis-stimulating agents (ESAs) between 2000 and 2010...
October 2015: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/26077406/immunosuppressive-therapies-for-the-maintenance-treatment-of-proliferative-lupus-nephritis-a-systematic-review-and-network-metaanalysis
#13
REVIEW
Simon Yu Tian, Brian M Feldman, Joseph Beyene, Patrick E Brown, Elizabeth M Uleryk, Earl D Silverman
OBJECTIVE: To determine the most effective immunosuppressive therapy for the longterm management of proliferative lupus nephritis (PLN) based on the outcome of renal failure. METHODS: A systematic review of randomized controlled trials (RCT) was conducted. MEDLINE and EMBASE were searched. RCT designed to examine the maintenance treatment effectiveness of immunosuppressive agents for PLN were included. A Bayesian network metaanalysis of 2-arm and 3-arm trials was used...
August 2015: Journal of Rheumatology
https://www.readbyqxmd.com/read/25894162/assessment-of-myocardial-mechanics-in-patients-with-end-stage-renal-disease-and-renal-transplant-recipients-using-speckle-tracking-echocardiography
#14
COMPARATIVE STUDY
Bahar Pirat, Huseyin Bozbas, Vahide Simsek, L Elif Sade, Burak Sayin, Haldun Muderrisoglu, Mehmet Haberal
OBJECTIVES: Velocity vector imaging allows quantitation of myocardial strain and strain rate from 2-dimensional images based on speckle tracking echocardiography. The aim of this study was to analyze the changes in myocardial strain and strain rate patterns in patients with end-stage renal disease and renal transplant recipients. MATERIALS AND METHODS: We studied 33 patients with end-stage renal disease on hemodialysis (19 men; mean age, 36 ± 8 y), 24 renal transplant recipients with functional grafts (21 men; mean age, 36 ± 7 y) and 26 age- and sex-matched control subjects...
April 2015: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/25894147/progression-of-hepatic-histopathology-in-kidney-transplant-recipients-with-chronic-hepatitis-c-virus-infection-and-effect-of-immunosuppression-on-the-course-of-hepatitis-c-virus-infection
#15
Murat Korkmaz, Sevgül Fakı, Serkan Öcal, Özgür Harmancı, Haldun Selçuk, Mehmet Haberal
OBJECTIVES: There is no correlation between alanine aminotransferase levels, viral load, and histologic findings at dialysis in patients with chronic hepatitis C virus infection. Identification of the severity of hepatitis C-related liver disease before transplant could provide valuable data about the risk for liverrelated mortality after transplant. In this study, we aimed to identify the severity of liver disease in endstage renal disease patients with chronic hepatitis C virus infection, the progression of hepatic histopathology after kidney transplant, and whether immunosuppressive therapy affected posttransplant viral replication and hepatic histology...
April 2015: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/25816806/pharmacokinetics-and-pharmacodynamics-of-pegloticase-in-patients-with-end-stage-renal-failure-receiving-hemodialysis
#16
Anthony J Bleyer, David Wright, Harry Alcorn
AIMS: Phase 3 trial data indicate that treatment of chronic tophaceous gout with pegloticase, a recombinant uricase conjugated to polyethylene glycol, does not reduce estimated glomerular filtration rate in chronic kidney disease (CKD) patients and that pegloticase therapeutics are independent of CKD stages 1 - 4. We determined the pharmacokinetics/pharmacodynamics of pegloticase after a single-dose in non-gout subjects with stage 5 CKD receiving hemodialysis. METHODS: In this open-label phase 1 study, 12 subjects received a single intravenous dose of pegloticase 8 mg 3 hours prior to hemodialysis...
May 2015: Clinical Nephrology
https://www.readbyqxmd.com/read/25816805/n-3-polyunsaturated-fatty-acids-and-adiponectin-in-patients-with-end-stage-renal-disease
#17
RANDOMIZED CONTROLLED TRIAL
Frederik Harving, My Svensson, Allan Flyvbjerg, Erik B Schmidt, Kaj A Jørgensen, Helle H Eriksen, Jeppe H Christensen
BACKGROUND AND AIM: In subjects without kidney disease, adiponectin appears to have anti-inflammatory, anti-diabetic, and anti-atherogenic effects. n-3 polyunsaturated fatty acids (PUFA) from seafood have several beneficial effects in patients with endstage renal disease (ESRD) and the aim of the present study was to assess the effect of n-3 PUFA supplementation on plasma adiponectin levels in ESRD patients. METHODS: In a double blinded intervention trial, 162 ESRD patients (mean age 67 years  ± 13, 56 women and 106 men) undergoing chronic hemodialysis were randomized to 1...
May 2015: Clinical Nephrology
https://www.readbyqxmd.com/read/25725233/esrd-burden-in-south-asia-the-challenges-we-are-facing
#18
REVIEW
Vivekanand Jha
South Asia, one of the most populous regions of the world, suffers from a large and increasing burden of untreated endstage renal disease (ESRD). Tropical ecology and increasing burden of non-communicable diseases are major drivers. Disease is diagnosed late, and access to treatment has been limited due to socioeconomic reasons but is increasing. System-level solutions, such as development of low-cost techniques and training of manpower to provide care to these patients are required. Individuals at high risk of developing progressive kidney disease should be identified early so that preventive measures can be instituted in a timely manner...
2015: Clinical Nephrology
https://www.readbyqxmd.com/read/25713705/translational-nephrology-what-translational-research-is-and-a-bird-s-eye-view-on-translational-research-in-nephrology
#19
Alberto Ortiz
The ultimate aim of biomedical research is to preserve health and improve patient outcomes. However, by a variety of measures, preservation of kidney health and patient outcomes in kidney disease are suboptimal. Severe acute kidney injury has been treated solely by renal replacement therapy for over 50 years and mortality still hovers at around 50%. Worldwide deaths from chronic kidney disease (CKD) increased by 80% in 20 years--one of the greatest increases among major causes of death. This dramatic data concur with huge advances in the cellular and molecular pathophysiology of kidney disease and its consequences...
February 2015: Clinical Kidney Journal
https://www.readbyqxmd.com/read/25619675/interplay-of-anxiety-and-depression-with-quality-of-life-in-endstage-renal-disease
#20
Andrew T Olagunju, Elizabeth A Campbell, Joseph D Adeyemi
BACKGROUND: Endstage renal disease (ESRD) is increasingly being recognized as a major public health issue globally. Planning of intervention measures is preferably hinged on what is known about outcome parameters. OBJECTIVES: This study investigated the influence of anxiety with depression and psychosocial- and treatment-related correlates on quality of life (QOL) in ESRD. METHODOLOGY: Overall, 100 eligible individuals with ESRD were recruited by systematic random sampling technique...
January 2015: Psychosomatics
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