keyword
https://read.qxmd.com/read/38539132/delays-in-multiple-sclerosis-diagnosis-dimes-protocol-for-a-multicentre-observational-study-of-multiple-sclerosis-diagnostic-pathways-in-the-united-kingdom-and-republic-of-ireland
#21
JOURNAL ARTICLE
Ashvin Kuri, David E Henshall, Daoud Chaudhry, Setthasorn Zhi Yang Ooi, Qiqi Zhang, Joela Mathews, Alison Thomson, David Rog, Jeremy Hobart, Ruth Dobson
BACKGROUND: Multiple sclerosis (MS) is a leading cause of non-traumatic disability in young adults. Accumulating evidence indicates early diagnosis and early treatment improves long-term outcomes. However, the MS diagnostic pathway is increasingly complex, and delays may occur at several stages. Factors causing delays remain understudied. We aim to quantify the time taken for MS to be diagnosed, and characterise the diagnostic pathway and initial care provided, in the United Kingdom (UK) and Republic of Ireland (ROI)...
March 28, 2024: BMC Neurology
https://read.qxmd.com/read/38539055/effect-of-complicated-untreated-and-uncontrolled-diabetes-and-pre-diabetes-on-treatment-outcome-among-patients-with-pulmonary-tuberculosis
#22
JOURNAL ARTICLE
Kyung Hoon Kim, Hyung Woo Kim, Yong Hyun Kim, Yeonhee Park, Sung Soo Jung, Jin Woo Kim, Jee Youn Oh, Heayon Lee, Sung Kyoung Kim, Sun-Hyung Kim, Jiwon Lyu, Yousang Ko, Sun Jung Kwon, Yun-Jeong Jeong, Do Jin Kim, Hyeon-Kyoung Koo, Yangjin Jegal, Sun Young Kyung, Sung Soon Lee, Jae Seuk Park, Ju Sang Kim, Jinsoo Min
BACKGROUND AND OBJECTIVE: Patients with tuberculosis and diabetes have a higher risk of unfavourable anti-tuberculosis treatment outcomes. In the present study, we aimed to evaluate the effects of various diabetes statuses on the outcomes of patients with pulmonary tuberculosis. METHODS: Among the patients with pulmonary tuberculosis enrolled in the Korea Tuberculosis Cohort (KTBC) registry and the multicentre prospective cohort study of pulmonary tuberculosis (COSMOTB), those with diabetes and complicated diabetes were identified...
March 27, 2024: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://read.qxmd.com/read/38539028/authorship-of-italian-medical-literature-on-neuroendocrine-neoplasms-any-gender-gap
#23
JOURNAL ARTICLE
R E Rossi, A La Salvia, R Modica, F Spada
PURPOSE: While males have dominated the physician lines over the last decades the recent female doctors' number increasing might progressively reduce this gender gap. This might be not fully true in the academic/research area. We aimed to analyze the gender distribution of first/senior Italian authors on neuroendocrine neoplasm papers published on peer reviewed journals. METHODS: Publications from January 2019 to September 2023 were reviewed; only papers with first and/or senior Italian authors were included...
March 28, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38538968/real-world-experience-with-pertuzumab-and-trastuzumab-combined-with-chemotherapy-in-neoadjuvant-treatment-for-patients-with-early-stage-her2-positive-breast-cancer-the-neopersur-study
#24
JOURNAL ARTICLE
Alejandro Falcón González, Josefina Cruz Jurado, Elisenda Llabrés Valenti, Rocío Urbano Cubero, Maria Carmen Álamo de la Gala, María Antonia Martínez Guisado, Rocío Álvarez Ambite, Carlos José Rodríguez González, Marta Amérigo Góngora, Lourdes Rodríguez Pérez, Pilar López Álvarez, Pedro Sánchez Rovira, Encarnación González Flores, Fernando Henao Carrasco, Juan Bayo Calero, María Valero Arbizu, Alicia Quílez Cutillas, Javier Salvador Boffil, Eloísa Rubio Pérez, Manuel Ruiz-Borrego
PURPOSE: HER2-targeted therapies have dramatically improved outcomes of patients with HER2-positive breast cancer (BC), as demonstrated in neoadjuvant trials. This study aims to provide real-world evidence on the use and effectiveness of combined pertuzumab, trastuzumab and chemotherapy (CT) in early-stage HER2-positive BC. METHODS: A retrospective, multicentre study was conducted on patients diagnosed with HER2-positive early BC treated with neoadjuvant pertuzumab and trastuzumab plus CT at 13 Spanish sites...
March 28, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38538433/corrigendum-to-analysis-of-domain-shift-in-whole-prostate-gland-zonal-and-lesions-segmentation-and-detection-using-multicentric-retrospective-data-comput-biol-med-17-2024-108216
#25
Nuno Miguel Rodrigues, José Guilherme de Almeida, Ana Sofia Castro Verde, Ana Mascarenhas Gaivão, Carlos Bilreiro, Inês Santiago, Joana Ip, Sara Belião, Raquel Moreno, Celso Matos, Leonardo Vanneschi, Manolis Tsiknakis, Kostas Marias, Daniele Regge, Sara Silva, Nickolas Papanikolaou
No abstract text is available yet for this article.
March 27, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38538161/acceptability-and-tolerability-of-long-acting-injectable-cabotegravir-or-rilpivirine-in-the-first-cohort-of-virologically-suppressed-adolescents-living-with-hiv-impaact-2017-mocha-a-secondary-analysis-of-a-phase-1-2-multicentre-open-label-non-comparative-dose
#26
JOURNAL ARTICLE
Elizabeth D Lowenthal, Jennifer Chapman, Rachel Ohrenschall, Katherine Calabrese, Kristin Baltrusaitis, Barbara Heckman, Dwight E Yin, Allison L Agwu, Conn Harrington, Rodica M Van Solingen-Ristea, Cynthia C McCoig, Adeola Adeyeye, Jared Kneebone, Vasiliki Chounta, Christiana Smith-Anderson, Andres Camacho-Gonzalez, Jessica D'Angelo, Allison Bearden, Herta Crauwels, Jenny Huang, Sarah Buisson, Ryan Milligan, Shawn Ward, Carolyn Bolton-Moore, Aditya H Gaur
BACKGROUND: Long-acting injectable cabotegravir and rilpivirine have demonstrated safety, acceptability, and efficacy in adults living with HIV-1. The IMPAACT 2017 study (MOCHA study) was the first to use these injectable formulations in adolescents (aged 12-17 years) living with HIV-1. Herein, we report acceptability and tolerability outcomes in cohort 1 of the study. METHODS: In this a secondary analysis of a phase 1/2, multicentre, open-label, non-comparative dose-finding study, with continuation of pre-study oral combination antiretroviral treatment (ART), 55 adolescents living with HIV-1 were enrolled to receive sequential doses of either long-acting cabotegravir or rilpivirine and 52 received at least two injections...
April 2024: Lancet HIV
https://read.qxmd.com/read/38538160/safety-and-pharmacokinetics-of-oral-and-long-acting-injectable-cabotegravir-or-long-acting-injectable-rilpivirine-in-virologically-suppressed-adolescents-with-hiv-impaact-2017-mocha-a-phase-1-2-multicentre-open-label-non-comparative-dose-finding-study
#27
JOURNAL ARTICLE
Aditya H Gaur, Edmund V Capparelli, Katherine Calabrese, Kristin Baltrusaitis, Mark A Marzinke, Cynthia McCoig, Rodica M Van Solingen-Ristea, Sisinyana Ruth Mathiba, Adeola Adeyeye, John H Moye, Barbara Heckman, Elizabeth D Lowenthal, Shawn Ward, Ryan Milligan, Pearl Samson, Brookie M Best, Conn M Harrington, Susan L Ford, Jenny Huang, Herta Crauwels, Kati Vandermeulen, Allison L Agwu, Christiana Smith-Anderson, Andres Camacho-Gonzalez, Pradthana Ounchanum, Jared L Kneebone, Ellen Townley, Carolyn Bolton Moore
BACKGROUND: Combined intramuscular long-acting cabotegravir and long-acting rilpivirine constitute the first long-acting combination antiretroviral therapy (ART) regimen approved for adults with HIV. The goal of the IMPAACT 2017 study (MOCHA [More Options for Children and Adolescents]) was to assess the safety and pharmacokinetics of these drugs in adolescents. METHODS: In this phase 1/2, multicentre, open-label, non-comparative, dose-finding study, virologically suppressed adolescents (aged 12-17 years; weight ≥35 kg; BMI ≤31·5 kg/m2 ) with HIV-1 on daily oral ART were enrolled at 15 centres in four countries (Botswana, South Africa, Thailand, and the USA)...
April 2024: Lancet HIV
https://read.qxmd.com/read/38538055/mechanical-thrombectomy-in-basilar-artery-occlusions-impact-of-first-line-strategy-as-a-function-of-the-occlusion-level
#28
JOURNAL ARTICLE
Louis Tournier, Jonathan Cortese, Arturo Consoli, Laurent Spelle, Gaultier Marnat, Mariana Sarov, Francois Zhu, Sebastien Soize, Julien Burel, Géraud Forestier, Simon Escalard, Raoul Pop, Baptiste Bonnet, Quentin Alias, Julien Ognard, Olivier Naggara, Maeva Kyheng, Bertrand Lapergue, Jildaz Caroff
BACKGROUND: Retrospective studies suggest the superiority of first-line contact aspiration (CA) thrombectomy over stent-retriever (SR) in basilar artery occlusions (BAO). We aimed to investigate the impact of first-line mechanical thrombectomy per the occlusion level, considering differences in stroke etiology prevalence between proximal and distal BAO. METHODS: A retrospective, multicentric analysis of the Endovascular Treatment in Ischemic Stroke Registry (ETIS) included consecutive BAO patients treated from January 2016 to May 2022...
March 27, 2024: Journal of Neurointerventional Surgery
https://read.qxmd.com/read/38537778/characteristics-knowledge-attitude-and-practice-of-pharmacy-personnel-in-supporting-tuberculosis-treatment-a-multicentre-cross-sectional-study-in-a-high-burden-tuberculosis-country
#29
JOURNAL ARTICLE
Ivan Surya Pradipta, Khairunnisa Khairunnisa, Muh Akbar Bahar, Mersa N Kausar, Efi Fitriana, Rovina Ruslami, Rob E Aarnoutse, Eli Halimah
BACKGROUND: Positive roles of community pharmacy in TB care have been widely reported. However, the actual practice of supporting TB treatment is not optimal yet. Therefore, we analyzed the current practice of community pharmacy personnel and its factors in supporting the successful treatment of TB patients in Indonesia, aiming to develop strategies for effective and sustainable TB practice models for the community pharmacy. METHODS: We performed a cross-sectional survey in three areas representing Indonesia's eastern, central, and western parts...
March 25, 2024: Journal of the American Pharmacists Association: JAPhA
https://read.qxmd.com/read/38537315/revolumab-a-phase-ii-trial-of-nivolumab-in-recurrent-idh-mutant-high-grade-gliomas
#30
JOURNAL ARTICLE
Alberto Picca, Mehdi Touat, Lisa Belin, Carole Gourmelon, Vincent Harlay, Stefania Cuzzubbo, Elizabeth Cohen-Jonathan Moyal, Charlotte Bronnimann, Anna Luisa Di Stefano, Isaura Laurent, Julie Lerond, Catherine Carpentier, Franck Bielle, François Ducray, Caroline Dehais
BACKGROUND: Novel effective treatments are needed for recurrent IDH mutant high-grade gliomas (IDHm HGGs). The aim of the multicentric, single-arm, phase II REVOLUMAB trial (NCT03925246) was to assess the efficacy and safety of the anti-PD1 Nivolumab in patients with recurrent IDHm HGGs. PATIENTS AND METHODS: Adult patients with IDHm WHO grade 3-4 gliomas recurring after radiotherapy and ≥ 1 line of alkylating chemotherapy were treated with intravenous Nivolumab until end of treatment (12 months), progression, unacceptable toxicity, or death...
March 22, 2024: European Journal of Cancer
https://read.qxmd.com/read/38536936/multiple-sclerosis-endophenotypes-identified-by-high-dimensional-blood-signatures-are-associated-with-distinct-disease-trajectories
#31
JOURNAL ARTICLE
Catharina C Gross, Andreas Schulte-Mecklenbeck, Olga V Steinberg, Timo Wirth, Sarah Lauks, Stefan Bittner, Patrick Schindler, Sergio E Baranzini, Sergiu Groppa, Judith Bellmann-Strobl, Nora Bünger, Claudia Chien, Eva Dawin, Maria Eveslage, Vinzenz Fleischer, Gabriel Gonzalez-Escamilla, Barbara Gisevius, Jürgen Haas, Martin Kerschensteiner, Lucienne Kirstein, Catharina Korsukewitz, Lisa Lohmann, Jan D Lünemann, Felix Luessi, Gerd Meyer Zu Hörste, Jeremias Motte, Tobias Ruck, Klemens Ruprecht, Nicholas Schwab, Falk Steffen, Sven G Meuth, Friedemann Paul, Brigitte Wildemann, Tania Kümpfel, Ralf Gold, Tim Hahn, Frauke Zipp, Luisa Klotz, Heinz Wiendl
One of the biggest challenges in managing multiple sclerosis is the heterogeneity of clinical manifestations and progression trajectories. It still remains to be elucidated whether this heterogeneity is reflected by discrete immune signatures in the blood as a surrogate of disease pathophysiology. Accordingly, individualized treatment selection based on immunobiological principles is still not feasible. Using two independent multicentric longitudinal cohorts of patients with early multiple sclerosis ( n = 309 discovery and n = 232 validation), we were able to identify three distinct peripheral blood immunological endophenotypes by a combination of high-dimensional flow cytometry and serum proteomics, followed by unsupervised clustering...
March 27, 2024: Science Translational Medicine
https://read.qxmd.com/read/38536762/the-impact-of-musculoskeletal-ill-health-on-quality-of-life-and-function-after-critical-care-a-multicentre-prospective-cohort-study
#32
JOURNAL ARTICLE
O D Gustafson, E B King, M M Schlussel, A Arnold, C Wade, P S Nicol, M J Rowland, H Dawes, M A Williams
Physical disability is a common component of post-intensive care syndrome, but the importance of musculoskeletal health in this population is currently unknown. We aimed to determine the musculoskeletal health state of intensive care unit survivors and assess its relationship with health-related quality of life; employment; and psychological and physical function. We conducted a multicentre prospective cohort study of adults admitted to intensive care for > 48 h without musculoskeletal trauma or neurological insult...
March 27, 2024: Anaesthesia
https://read.qxmd.com/read/38536470/a-multicentre-survey-on-the-perception-of-palliative-care-among-health-professionals-working-in-haematology
#33
JOURNAL ARTICLE
Sara Di Lorenzo, Lisa Mozzi, Flavia Salmaso, Claudia Silvagni, Silvia Soffientini, Vanessa Valenti, Vittorina Zagonel
PURPOSE: Patients with haematologic malignancies have less access to palliative care and are referred later than patients with solid tumours. We developed a survey to investigate this phenomenon, with the intention of analysing palliative care perceptions among health professionals who treat haematology patients and identifying barriers and facilitators to referrals to palliative care services. METHODS: This was a multicentre exploratory descriptive web-based survey...
March 27, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38536468/traumatic-rhabdomyolysis-rare-but-morbid-potentially-lethal-and-inconsistently-monitored
#34
JOURNAL ARTICLE
Thomas Giles, Kate King, Simone Meakes, Natasha Weaver, Zsolt J Balogh
PURPOSE: Although traumatic rhabdomyolysis (TR) is shown to be associated with acute kidney injury (AKI), there are no large prospective epidemiological studies, interventional trials, official guidelines outlining the appropriate investigation, monitoring, and treatment on this poorly understood condition. We aimed to establish the contemporary epidemiology and describe current practices for TR to power future higher quality studies. We hypothesised that investigation and monitoring occur in an ad hoc fashion...
March 27, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://read.qxmd.com/read/38536127/the-impact-of-low-energy-partially-hydrolysed-enteral-formula-on-gastrointestinal-symptoms-and-weight-in-children-with-neurological-impairment-a-multicentre-retrospective-study
#35
JOURNAL ARTICLE
Graeme O'Connor, Martha Van Der Linde, Zoltan Hartfiel Capriles
BACKGROUND: Neurological impairment (NI) relates to disorders of the central nervous system. The specific aetiology of NI varies but includes genetic, congenital abnormalities or brain injury. In children with severe NI, feeding impairments can lead to undernutrition, and some children require a feeding tube. Although tube feeding improves overall nutritional status, it has also been associated with excess body fat. Commercially available enteral formulas that are low in energy, hydrolysed and nutritionally adequate for protein and micronutrients are available to mitigate gastrointestinal symptoms and obesity...
March 27, 2024: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://read.qxmd.com/read/38535873/transitional-dynamics-in-oncology-clinical-trials-evaluating-the-impact-of-clinical-trials-act-on-cooperative-groups
#36
JOURNAL ARTICLE
Kenichi Nakamura, Koji Takeda, Akiko M Saito, Miho Kato, Shinya Sato, Satoshi Nakagawa, Yasuyuki Kawamoto, Eiji Oki, Isamu Okamoto, Hiroaki Okamoto, Hiroshi Katayama, Junki Mizusawa, Harumi Kaba, Taro Shibata, Haruhiko Fukuda
OBJECTIVE: large-scale multicentre clinical trials conducted by cooperative groups have generated a lot of evidence to establish better standard treatments. The Clinical Trials Act was enforced on 1 April 2018, in Japan, and it has remarkably increased the operational burden on investigators, but its long-term impact on cancer cooperative groups is unknown. METHODS: a survey was conducted across the nine major cooperative groups that constitute the Japan Cancer Trials Network to assess the impact of Clinical Trials Act on the number of newly initiated trials from fiscal year (from 1 April to 31 March) 2017 to 2022 and that of ongoing trials on 1 April in each year from 2018 to 2023...
March 26, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38534990/safety-and-diagnostic-yield-of-medical-pleuroscopy-mp-performed-under-balanced-analgosedation-by-a-pneumological-team-compared-to-video-assisted-thoracic-surgery-vats-a-retrospective-controlled-real-life-study-torapo
#37
JOURNAL ARTICLE
Valentino Allocca, Luca Guidelli, Angela Galgano, Lucia Benedetti, Roberto Fabbroni, Andrea Bianco, Piero Paladini, Raffaele Scala
INTRODUCTION: Medical pleuroscopy (MP) is an invasive technique that provides access to the pleural space with a rigid or semi-rigid work instrument, allowing for visualization and the obtaining of bioptic pleural samples. Using pulmonologist-based analgosedation to perform pleuroscopy is still debated for safety reasons. The aim of this real-life study is to demonstrate the safety and diagnostic yield of MP performed under balanced analgosedation by a pulmonologist team with expertise in the management of critically ill patients in the respiratory intensive care unit (RICU) and interventional pulmonology unit as compared to video-assisted thoracic surgery (VATS) performed by a thoracic surgeon team under anesthesiologist-based analgosedation...
March 7, 2024: Diagnostics
https://read.qxmd.com/read/38534959/outcomes-of-patients-with-non-small-cell-lung-cancer-and-brain-metastases-treated-with-the-upfront-single-agent-pembrolizumab-a-retrospective-and-multicentric-study-of-the-esckeyp-gfpc-cohort
#38
MULTICENTER STUDY
Simon Nannini, Florian Guisier, Hubert Curcio, Charles Ricordel, Pierre Demontrond, Safa Abdallahoui, Seyyid Baloglu, Laurent Greillier, Christos Chouaid, Roland Schott
Non-small cell lung cancer (NSCLC) is the most common cause of brain metastasis (BM). Little is known about immune checkpoint inhibitor activity in the central nervous system, especially in patients receiving monotherapy for tumors with a tumor proportion score (TPS) ≥ 50%. This noninterventional, retrospective, multicenter study, conducted with the GFPC, included treatment-naïve patients strongly positive for PD-L1 (TPS ≥ 50%) with BM receiving first-line single-agent pembrolizumab treatment between May 2017 and November 2019...
March 21, 2024: Current Oncology
https://read.qxmd.com/read/38534146/long-term-survivorship-of-the-herbert-ulnar-head-prosthesis-a-multicentre-retrospective-cohort-study
#39
JOURNAL ARTICLE
Lucy C Maling, Andrew M Smith, Mark Williamson
IV.
March 27, 2024: Journal of Hand Surgery, European Volume
https://read.qxmd.com/read/38534084/acceptability-and-usability-of-self-sampling-for-the-detection-of-sexually-transmitted-infections-among-transgender-women-the-transodara-multicentric-study-in-brazil
#40
JOURNAL ARTICLE
Daniel Jason McCartney, Katia Cristina Bassichetto, Andrea Fachel Leal, Daniela Knauth, Inês Dourado, Laio Magno, Roberto José Carvalho da Silva, Philippe Mayaud, Maria Amélia Veras
BACKGROUND: The effective testing of sexually transmitted infections (STIs) requires sampling from potential infection sites. This study aimed to assess the choice, satisfaction, and performance of self-collected samples (SCS) from potential infection sites for STI testing among transgender women in Brazil. METHODS: TransOdara was a multicentric, cross-sectional STI prevalence study conducted in 5 Brazilian cities. Using respondent-driven sampling, 1317 transgender women 18 years or older were recruited...
April 1, 2024: Sexually Transmitted Diseases
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