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https://www.readbyqxmd.com/read/28938580/diagnostic-significance-of-urinary-long-non-coding-pca3-rna-in-prostate-cancer
#1
Tao Wang, Xiangyun Qu, Jiajia Jiang, Peng Gao, Dingding Zhao, Xueqi Lian, Xiaohua Li
Prostate cancer antigen 3(PCA3) is a long non-coding RNA, which was found increased expression in CaP patients than healthy individual. In this study, the individual nucleic acid of PCA3 and PSA was recombinant expressed as a reference reagent, and a quantitative RT-PCR with TaqMan assay was developed to examine the copies of PCA3 and PSA gene in urine. The results showed that the area under the receiver operating characteristic curve (AUROC) was 0.717, 0.444 and 0.916 for the number of PCA3 copy, PSA copy and for the score of PCA3/PSA RNA, respectively...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937383/multicentric-papillary-and-chromophobe-renal-cell-carcinomas-in-a-patient-with-autosomal-dominant-polycystic-kidney-disease-report-of-a-rare-case
#2
Nibedita Sahoo, Susama Patra, Swagatika Senapati, Tushar S Mishra
The causal relationship of autosomal dominant polycystic kidney disease (ADPKD) with the development of renal cell carcinoma (RCC) is still not known. We describe a case of bilateral PKD complicated with a large enhancing mass and multiple small nodules in the left kidney. The histopathological study of the nephrectomy specimen revealed the synchronous occurrence of eosinophilic variant of chromophobe RCC (EVCRCC) and multicentric papillary RCC (PRCC) in a background of ADPKD. To the best of our knowledge, this case is the first to describe the collision tumor of EVCRCC and multicentric PRCC in ADPKD...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28936597/terminal-weaning-or-immediate-extubation-for-withdrawing-mechanical-ventilation-in-critically-ill-patients-the-arreve-observational-study
#3
René Robert, Amélie Le Gouge, Nancy Kentish-Barnes, Alice Cottereau, Bruno Giraudeau, Mélanie Adda, Djillali Annane, Juliette Audibert, François Barbier, Patrick Bardou, Simon Bourcier, Jeremy Bourenne, Alexandre Boyer, François Brenas, Vincent Das, Arnaud Desachy, Jérôme Devaquet, Marc Feissel, Frédérique Ganster, Maïté Garrouste-Orgeas, Guillaume Grillet, Olivier Guisset, Rebecca Hamidfar-Roy, Anne-Claire Hyacinthe, Sebastien Jochmans, Mercé Jourdain, Alexandre Lautrette, Nicolas Lerolle, Olivier Lesieur, Fabien Lion, Philippe Mateu, Bruno Megarbane, Sybille Merceron, Emmanuelle Mercier, Jonathan Messika, Paul Morin-Longuet, Bénédicte Philippon-Jouve, Jean-Pierre Quenot, Anne Renault, Xavier Repesse, Jean-Philippe Rigaud, Ségolène Robin, Antoine Roquilly, Amélie Seguin, Didier Thevenin, Patrice Tirot, Isabelle Vinatier, Elie Azoulay, Jean Reignier
PURPOSE: The relative merits of immediate extubation versus terminal weaning for mechanical ventilation withdrawal are controversial, particularly regarding the experience of patients and relatives. METHODS: This prospective observational multicentre study (ARREVE) was done in 43 French ICUs to compare terminal weaning and immediate extubation, as chosen by the ICU team. Terminal weaning was a gradual decrease in the amount of ventilatory assistance and immediate extubation was extubation without any previous decrease in ventilatory assistance...
September 22, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28936374/helical-tomotherapy-for-postmastectomy-radiotherapy-after-immediate-left-breast-reconstruction-a-case-study
#4
Dominique Mathieu, Nazanin Shahvary, Nicolas Côté, Kerianne Boulva, Léamarie Meloche-Dumas, Toni Vu, Erica Patocskai, Christina Bernier, David Roberge, Israel Fortin
A 43-year-old premenopausal female presented with a multicentric infiltrating lobular carcinoma of the left breast with axillary nodes metastasis. She underwent modified radical mastectomy with axillary lymph node dissection (level I and II) followed by a mixed autologous latissimus dorsi flap reconstruction with the addition of prosthesis. The final pathological analysis revealed a 6 cm invasive lobular carcinoma pT3N2aM0, grade III/III, estrogen and progesterone positive, human epidermal growth factor receptor 2 (HER2) negative, with 5/16 positive lymph nodes...
July 12, 2017: Curēus
https://www.readbyqxmd.com/read/28935850/viro-immunological-response-of-drug-naive-hiv-1-infected-patients-starting-a-first-line-regimen-with-viraemia-500-000-copies-ml-in-clinical-practice
#5
Maria Mercedes Santoro, Domenico Di Carlo, Daniele Armenia, Mauro Zaccarelli, Carmela Pinnetti, Manuela Colafigli, Francesca Prati, Andrea Boschi, Anna Maria Degli Antoni, Filippo Lagi, Laura Sighinolfi, Cristina Gervasoni, Massimo Andreoni, Andrea Antinori, Cristina Mussini, Carlo Federico Perno, Vanni Borghi, Gaetana Sterrantino
BACKGROUND: Virological success (VS) and immunological reconstitution (IR) of antiretroviral-naïve HIV-1 infected patients with pre-therapy viral load (VL) >500,000 copies/mL was assessed after 12 months of treatment according to initial drug-class regimens. METHODS: An observational multicenter retrospective study was performed. VS was defined as the first VL <50 copies/mL from treatment start. IR was defined as an increase of at least 150 CD4+ T-lymphocytes from treatment start...
September 22, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28935546/fluorescein-guided-resection-of-intramedullary-spinal-cord-tumors-results-from-a-preliminary-multicentric-retrospective-study
#6
Francesco Acerbi, Claudio Cavallo, Karl-Michael Schebesch, Mehmet Osman Akcakaya, Camilla de Laurentis, Mustafa Kemal Hamamcioglu, Morgan Broggi, Alexander Brawanski, Jacopo Falco, Roberto Cordella, Paolo Ferroli, Telat Kiris, Julius Höhne
INTRODUCTION: IMSCTs are rare heterogenous lesions usually enhancing at pre-operative MRI, due to a damaged BBB. SF is a dye that accumulates in areas of the CNS with a damaged BBB. Given the pattern of MRI contrast-enhancement of the majority of IMSCTs, the use of this fluorescent tracer could improve tumor visualization and quality of resection. In this paper, we present the first experience on the application of fluorescein-guided technique for surgical removal of IMSCTs. METHODS: 11 patients (6 males, 5 females, mean age 50...
September 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28935492/clinical-predictors-of-response-and-discontinuation-of-belimumab-in-patients-with-systemic-lupus-erythematosus-in-real-life-setting-results-of-a-large-multicentric-nationwide-study
#7
Luca Iaccarino, Laura Andreoli, Elena Bartoloni Bocci, Alessandra Bortoluzzi, Fulvia Ceccarelli, Fabrizio Conti, Rossella De Angelis, Ginevra De Marchi, Salvatore De Vita, Andrea Di Matteo, Giacomo Emmi, Lorenzo Emmi, Mariele Gatto, Roberto Gerli, Maria Gerosa, Marcello Govoni, Maddalena Larosa, Pier Luigi Meroni, Marta Mosca, Giulia Pazzola, Rossella Reggia, Francesca Saccon, Carlo Salvarani, Chiara Tani, Margherita Zen, Anna Chiara Frigo, Angela Tincani, Andrea Doria
OBJECTIVE: To investigate efficacy, safety and survival of belimumab and to identify predictors of drug response and drug discontinuation in patients with active SLE in clinical practice. PATIENTS AND METHODS: Data of SLE patients, treated with belimumab, from 11 Italian prospective cohorts were analyzed. SLEDAI-2K, anti-dsDNA, C3, C4, prednisone daily dose, DAS-28, 24-h proteinuria, CLASIa (Cutaneous LE Disease Area and Severity Index Activity) were recorded at baseline and every 6 months...
September 18, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28935489/perinatal-complications-in-patients-with-unisutural-craniosynostosis-an-international-multicentre-retrospective-cohort-study
#8
Martijn J Cornelissen, Madiha Söfteland, Inge Apon, Lars Ladfors, Irene M J Mathijssen, Titia E Cohen-Overbeek, Gouke J Bonsel, Lars Kölby
PURPOSE: Craniosynostosis may lead to hampered fetal head molding and birth complications. To study the interaction between single suture craniosynostosis and delivery complications, an international, multicentre, retrospective cohort study was performed. MATERIALS AND METHODS: All infants born between 2006 and 2012 in the Netherlands and Sweden with sagittal or metopic suture synostosis were included. All births were included as a reference population. The primary outcome measure was rate of medically assisted labor...
August 19, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28935459/clinical-and-pathologic-features-of-clinically-occult-synchronous-bilateral-breast-cancers
#9
Lumarie Santiago, Gary Whitman, Cuiyan Wang, Basak E Dogan
PURPOSE: To investigate clinicopathologic breast cancer characteristics associated with the identification of synchronous bilateral breast cancer (SBBC) on dynamic contrast-enhanced breast magnetic resonance imaging. METHODS: We performed a retrospective review of 311 consecutive patients newly diagnosed with breast cancer who underwent diagnostic mammography, ultrasonography, and dynamic contrast-enhanced breast magnetic resonance imaging (DCE-MRI) at our institution...
August 24, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28934837/bromocriptine-for-the-treatment-of-peripartum-cardiomyopathy-a-multicentre-randomized-study
#10
Denise Hilfiker-Kleiner, Arash Haghikia, Dominik Berliner, Jens Vogel-Claussen, Johannes Schwab, Annegret Franke, Marziel Schwarzkopf, Philipp Ehlermann, Roman Pfister, Guido Michels, Ralf Westenfeld, Verena Stangl, Ingrid Kindermann, Uwe Kühl, Christiane E Angermann, Axel Schlitt, Dieter Fischer, Edith Podewski, Michael Böhm, Karen Sliwa, Johann Bauersachs
Aims: An anti-angiogenic cleaved prolactin fragment is considered causal for peripartum cardiomyopathy (PPCM). Experimental and first clinical observations suggested beneficial effects of the prolactin release inhibitor bromocriptine in PPCM. Methods and results: In this multicentre trial, 63 PPCM patients with left ventricular ejection fraction (LVEF) ≤35% were randomly assigned to short-term (1W: bromocriptine, 2.5 mg, 7 days) or long-term bromocriptine treatment (8W: 5 mg for 2 weeks followed by 2...
September 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28933799/rivaroxaban-for-preventing-venous-thromboembolism-in-high-risk-ambulatory-patients-with-cancer-rationale-and-design-of-the-cassini-trial-rationale-and-design-of-the-cassini-trial
#11
Alok Khorana, Saroj Vadhan-Raj, Nicole M Kuderer, Ted Wun, Howard Liebman, Gerald Soff, Chandra Belani, Eileen M O'Reilly, Robert McBane, John Eikelboom, C V Damaraju, Karen Beyers, Flavia Dietrich, Ajay Kakkar, Hanno Riess, Renata D'Alpino Peixoto, Gary H Lyman
Venous thromboembolism (VTE) is a frequent complication of cancer associated with morbidity, mortality, increased hospitalizations and higher health care costs. Cancer patients at increased risk for VTE can be identified using a validated risk assessment score, and the incidence of VTE can be reduced in high-risk settings using anticoagulation. Rivaroxaban is a potent, oral, direct, factor Xa inhibitor approved for the prevention and treatment of thromboembolic events, including VTE. CASSINI is a double-blind, randomized, parallel-group, multicentre study comparing rivaroxaban with placebo in adult ambulatory patients with various cancers who are initiating systemic cancer therapy and are at high risk of VTE (Khorana score ≥ 2)...
September 21, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28931394/the-efficacy-of-initial-ventilation-strategy-for-adult-immunocompromised-patients-with-severe-acute-hypoxemic-respiratory-failure-study-protocol-for-a-multicentre-randomized-controlled-trial-venim
#12
Tao Wang, Gang Liu, Kun He, Xin Lu, Xianquan Liang, Meng Wang, Rong Zhu, Zongru Li, Feng Chen, Jun Ke, Qingming Lin, Chuanyun Qian, Bo Li, Jie Wei, Jingjun Lv, Li Li, Yanxia Gao, Guofeng Wu, Xiaohong Yu, Weiqin Wei, Ying Deng, Fengping Wang, Hong Zhang, Yun Zheng, Hong Zhan, Jinli Liao, Yingping Tian, Dongqi Yao, Jingsong Zhang, Xufeng Chen, Lishan Yang, Jiali Wu, Yanfen Chai, Songtao Shou, Muming Yu, Xudong Xiang, Dongshan Zhang, Fengying Chen, Xiufeng Xie, Yong Li, Bo Wang, Wenzhong Zhang, Yongli Miao, Michael Eddleston, Jianqiang He, Yong Ma, Shengyong Xu, Yi Li, Huadong Zhu, Xuezhong Yu
BACKGROUND: Acute respiratory failure (ARF) is still one of the most severe complications in immunocompromised patients. Our previous systematic review showed noninvasive mechanical ventilation (NIV) reduced mortality, length of hospitalization and ICU stay in AIDS/hematological malignancy patients with relatively less severe ARF, compared to invasive mechanical ventilation (IMV). However, this systematic review was based on 13 observational studies and the quality of evidence was low to moderate...
September 20, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28931148/previous-exposure-in-a-high-risk-area-for-travellers-diarrhoea-within-the-past-year-is-associated-with-a-significant-protective-effect-for-travellers-diarrhoea-a-prospective-observational-cohort-study-in-travellers-to-south-asia
#13
Esther Kuenzli, David Juergensen, Kerstin Kling, Veronika K Jaeger, Susan DeCrom, Robert Steffen, Andreas F Widmer, Manuel Battegay, Christoph Hatz, Andreas Neumayr
Background: Travellers' diarrhoea is the most common health problem in travellers. Depending on the region visited, up to 40% of travellers develop diarrhoea during a 2-week trip. The aim of this study was to assess risk factors for TD among travellers to the Indian subcontinent. Methods: An observational prospective multicentre cohort study investigated travellers to the Indian subcontinent. Participants completed questionnaires assessing the incidence of travellers' diarrhoea and identifying potential risk factors...
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28931051/interleukin-17-positive-mast-cells-influence-outcomes-from-bcg-for-patients-with-cis-data-from-a-comprehensive-characterisation-of-the-immune-microenvironment-of-urothelial-bladder-cancer
#14
Alexander C Dowell, Ellen Cobby, Kaisheng Wen, Adam J Devall, Vinnie During, Jane Anderson, Nicholas D James, Kar K Cheng, Maurice P Zeegers, Richard T Bryan, Graham S Taylor
The tumour immune microenvironment is considered to influence cancer behaviour and outcome. Using a panel of markers for innate and adaptive immune cells we set out to characterise and understand the bladder tumour microenvironment of 114 patients from a prospective multicentre cohort of newly-diagnosed bladder cancer patients, followed-up for 4.33±1.71 years. We found IL-17-positive cells were significantly increased in primary and concomitant carcinoma in situ (CIS), p<0.0001, a highly malignant lesion which is the most significant single risk factor for disease progression...
2017: PloS One
https://www.readbyqxmd.com/read/28930059/the-role-of-alcohol-on-antiretroviral-therapy-adherence-among-persons-living-with-hiv-in-urban-india
#15
Stephen L Schensul, Toan Ha, Jean J Schensul, Melita Vaz, Rajendra Singh, Joseph A Burleson, Kendall Bryant
OBJECTIVE: The purpose of this study was to estimate the prevalence of alcohol use among men living with HIV on antiretroviral therapy (ART) and examine the association of alcohol use and psychosocial variables on ART adherence. The study was a cross-sectional survey supplemented by medical records and qualitative narratives as a part of the initial formative stage of a multilevel, multicentric intervention and evaluation project. METHOD: A screening instrument was administered to men living with HIV (n = 3,088) at four ART Centers using the Alcohol Use Disorders Identification Test-consumption questions (AUDIT-C) to determine alcohol use for study eligibility...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28929948/moderately-high-protein-enteral-formula-improved-retinol-binding-protein-in-tube-fed-patients-a-multicentre-open-study
#16
Veeradej Pisprasert, Prapimporn Chattranukulchai Shantavasinkul, Sornwichate Rattanachaiwong, Tanarat Lepananon, Surat Komindr
BACKGROUND: Long-term inadequate dietary consumption may increase the possibility of malnutrition, morbidity and mortality. Enteral nutrition (EN) is a beneficial support that could help to maintain nutritional status and gut function. AIM: Our aim was to evaluate the effect of moderately high-protein enteral formula containing fibre on nutritional status, and its safety. METHOD: A total of 23 tube-feeding-dependent adult patients were included in this multicentre, open-label study...
September 2017: Nutrition and Health
https://www.readbyqxmd.com/read/28929389/plate-fixation-of-the-proximal-humerus-an-international-multicentre-comparative-study-of-postoperative-complications
#17
Frank J P Beeres, N D L Hallensleben, S J Rhemrev, J C Goslings, F Oehme, S A G Meylaerts, R Babst, N W L Schep
OBJECTIVE: The primary aim was to evaluate the number of complications following locking plate fixation of proximal humeral fractures in country X and in country Y. The secondary aim was to identify risk factors for complications. METHODS: Multicentre retrospective case series of 282 consecutive patients with proximal humeral fractures, treated with a locking plate between 2010 and 2014. SETTING: two level 1 trauma centres in country X and one in country Y...
September 19, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28929341/margin-status-is-still-an-important-prognostic-factor-in-hepatectomies-for-colorectal-liver-metastases-a-propensity-score-matching-analysis
#18
Riccardo Memeo, Vito de Blasi, Rene Adam, Diane Goéré, Tullio Piardi, Emilie Lermite, Olivier Turrini, Francis Navarro, Nicola de'Angelis, Antonio Sa Cunha, Patrick Pessaux
OBJECTIVE: The width of resection margin is still a matter of debate in case of colorectal liver metastasis resection. The aim of this study was to determine the risk factors for R1 resection. Once risk factors had been identified, patients were matched according to Fong's prognostic criteria, in order to evaluate whether R1 resection still remained a negative prognostic factor impacting overall and disease-free survival. METHODS: A total of 1784 hepatectomies were analyzed from a multicentric retrospective cohort of hepatectomies...
September 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28928186/recombinant-human-tnk-tissue-type-plasminogen-activator-rhtnk-tpa-versus-alteplase-rt-pa-as-fibrinolytic-therapy-for-acute-st-segment-elevation-myocardial-infarction-china-tnk-stemi-protocol-for-a-randomised-controlled-non-inferiority-trial
#19
Hai-Bo Wang, Ping Ji, Xing-Shan Zhao, Haiyan Xu, Xiao-Yan Yan, Qin Yang, Chen Yao, Run-Lin Gao, Yang-Feng Wu, Shu-Bin Qiao
AIM: To evaluate the efficacy and safety of recombinant human TNK tissue-type plasminogen activator (rhTNK-tPA) in lowering major adverse cardiovascular and cerebrovascular events (MACCEs) in Chinese acute ST-segment elevation myocardial infarction (STEMI) patients. METHODS AND ANALYSIS: The study is designed as a multicentre, randomised, controlled non-inferiority phase IV trial with balanced randomisation (1:1) in patients with STEMI. The planned sample size is 6200 participants (or 3100 per arm)...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28928175/integrated-management-of-atrial-fibrillation-including-tailoring-of-anticoagulation-in-primary-care-study-design-of-the-all-in-cluster-randomised-trial
#20
Carline J van den Dries, Ruud Oudega, Arif Elvan, Frans H Rutten, Sjef J C M van de Leur, Henk J G Bilo, Arno W Hoes, Karel G M Moons, Geert-Jan Geersing
INTRODUCTION: In our ageing society, we are at the merge of an expected epidemic of atrial fibrillation (AF). AF management requires an integrated approach, including rate or rhythm control, stroke prevention with anticoagulation and treatment of comorbidities such as heart failure or type 2 diabetes. As such, primary care seems to be the logical healthcare setting for the chronic management of patients with AF. However, primary care has not yet played a dominant role in AF management, which has been in fact more fragmented between different healthcare providers...
September 18, 2017: BMJ Open
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