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https://www.readbyqxmd.com/read/29783148/comparative-study-of-six-sequential-spectrophotometric-methods-for-quantification-and-separation-of-ribavirin-sofosbuvir-and-daclatasvir-an-application-on-laboratory-prepared-mixture-pharmaceutical-preparations-spiked-human-urine-spiked-human-plasma-and-dissolution
#1
Wafaa S Hassan, Manal S Elmasry, Heba M Elsayed, Dalia W Zidan
In accordance with International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidelines, six novel, simple and precise sequential spectrophotometric methods were developed and validated for the simultaneous analysis of Ribavirin (RIB), Sofosbuvir (SOF), and Daclatasvir (DAC) in their mixture without prior separation steps. These drugs are described as co-administered for treatment of Hepatitis C virus (HCV). HCV is the cause of hepatitis C and some cancers such as liver cancer (hepatocellular carcinoma) and lymphomas in humans...
May 18, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29782897/metal-concentrations-in-fillet-and-gill-of-parrotfish-scarus-ghobban-from-the-persian-gulf-and-implications-for-human-health
#2
Yadolah Fakhri, Narottam Saha, Ali Miri, Aziz Rahimizadeh, Laleh Roomiani, Mansour Ghaderpoori, Mahmoud Taghavi, Hassan Keramati, Zohreh Bahmani, Bigard Moradi, Nazak Amanidaz
Despite the benefits of seafood's consumption, the bioaccumulation of metals in fish can endanger consumers' health. This study analyzed lead (Pb), mercury (Hg), Arsenic (As), and Cadmium (Cd) concentrations in fillet and gill of parrotfish (Scarus ghobban) using flame atomic adsorption spectroscopy (FAAS). The potential non-carcinogenic and carcinogenic health risks due to consumption of Scarus ghobban fillet were assessed by estimating average target hazard quotient (THQ) and total target hazard quotient (TTHQ) and Incremental Lifetime Cancer Risk cancer risk (ILCR) of the analyzed metals...
May 18, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29780222/role-of-concentric-needle-single-fiber-electromyography-in-detection-of-subclinical-motor-involvement-in-carpal-tunnel-syndrome
#3
Aliaa A Tawfeek, Amani M Nawito, Radwa M Azmy, Amr Hassan, Lamia M Afifi, Saly H Elkholy
Background: Conventional motor nerve conduction studies are usually normal in early and mild carpal tunnel syndrome (CTS). Single-fiber electromyography (SFEMG) measures the mean consecutive difference (MCD) as an expression of the variability in impulse transmission over the motor endplates and along the nerve fibers distally to the last branching point and along the muscle fibers.Application of concentric needle SFEMG in a group of CTS patients who showed pure sensory abnormalities in nerve conduction studies to examine for subclinical motor involvement...
2018: Egypt J Neurol Psychiatr Neurosurg
https://www.readbyqxmd.com/read/29779504/association-of-dietary-patterns-of-american-adults-with-bone-mineral-density-and-fracture
#4
Mohsen Mazidi, Andre Pascal Kengne, Hassan Vatanparast
OBJECTIVE: In a representative sample of US adults, we investigated the associations of nutrient patterns (NP) with bone mineral density (BMD) and fractures. DESIGN: Cross-sectional. SETTING: US community-based National Health and Nutrition Examination Survey (NHANES). SUBJECTS: Participants with measured data on dietary intake and BMD from 2005 to 2010 were included. Principal components analysis was used to identify NP...
May 21, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29778996/stent-and-flow-diverter-assisted-treatment-of-acutely-ruptured-brain-aneurysms
#5
José E Cohen, J Moshe Gomori, Ronen R Leker, Sergey Spektor, Hosni Abu El Hassan, Eyal Itshayek
OBJECTIVE: We present our experience with stent techniques in the management of acutely ruptured aneurysms, focusing on aneurysm occlusion rates, intraprocedural complications, and late outcomes. METHODS: We retrospectively reviewed the clinical records of patients treated by stent techniques during the early acute phase of aneurysmal rupture, from June 2011 to June 2016. Patients who underwent stenting for the management of unruptured aneurysms, or in a delayed fashion for a ruptured lesion, were excluded...
May 19, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29778931/monitoring-tool-usage-in-surgery-videos-using-boosted-convolutional-and-recurrent-neural-networks
#6
Hassan Al Hajj, Mathieu Lamard, Pierre-Henri Conze, Béatrice Cochener, Gwenolé Quellec
This paper investigates the automatic monitoring of tool usage during a surgery, with potential applications in report generation, surgical training and real-time decision support. Two surgeries are considered: cataract surgery, the most common surgical procedure, and cholecystectomy, one of the most common digestive surgeries. Tool usage is monitored in videos recorded either through a microscope (cataract surgery) or an endoscope (cholecystectomy). Following state-of-the-art video analysis solutions, each frame of the video is analyzed by convolutional neural networks (CNNs) whose outputs are fed to recurrent neural networks (RNNs) in order to take temporal relationships between events into account...
May 9, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29778725/who-s-a-gonna-hold-your-hard-luck-hand-and-who-s-a-gonna-be-your-man-bob-dylan-kingsport-town
#7
EDITORIAL
Ferdinand Kiemeneij, Ahmed A Hassan
No abstract text is available yet for this article.
May 11, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29777910/differentially-expressed-novel-alternatively-spliced-transcript-variant-of-tumor-suppressor-stk11-gene-in-mouse
#8
Hassan Mubarak Ishqi, Tarique Sarwar, Mohammed Amir Husain, Sayeed Ur Rehman, Mohammad Tabish
Serine/threonine kinase 11 (STK11) is a protein kinase that is encoded by Stk11 gene located on chromosome 19 and 10 in humans and mouse respectively. It acts as a master kinase of adenine monophosphate-activated protein kinase (AMPK) pathway that coordinates the regulation of cellular energy metabolism and cell division. STK11 exerts effect by activating more than 14 kinases including AMPK and AMPK-related kinases. It is also known to regulate cell polarity and acts as tumor suppressor. Alternative splicing of pre-mRNA is a mechanism which results in multiple transcript variants of a single gene...
May 16, 2018: Gene
https://www.readbyqxmd.com/read/29776792/brocq-pautrier-s-angiolupoid
#9
Mohamed Elqatni, Hassan Qacif, Mohamed Zyani, Driss Ghafir, Toufiq Amezyane
No abstract text is available yet for this article.
May 15, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29776725/collaterals-management-during-pancreatoduodenectomy-in-patients-with-celiac-axis-stenosis-a-systematic-review-of-the-literature
#10
REVIEW
Francesco Giovanardi, Quirino Lai, Manuela Garofalo, Gabriela A Arroyo Murillo, Eleonore Choppin de Janvry, Redan Hassan, Zoe Larghi Laureiro, Adriano Consolo, Fabio Melandro, Pasquale B Berloco
BACKGROUND/OBJECTIVES: Celiac axis stenosis (CAS) represents an uncommon and typically innocuous condition. However, when a pancreatic resection is required, a high risk for upper abdominal organs ischemia is observed. In presence of collaterals, such a risk is minimized if their preservation is realized. The aim of the present study is to systematically review the literature with the intent to address the routine management of collateral arteries in the case of CAS patients requiring pancreatoduodenectomy...
May 15, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29776416/rapid-urease-test-rut-for-evaluation-of-urease-activity-in-oral-bacteria-in-vitro-and-in-supragingival-dental-plaque-ex-vivo
#11
Gunnar Dahlén, Haidar Hassan, Susanne Blomqvist, Anette Carlén
BACKGROUND: Urease is an enzyme produced by plaque bacteria hydrolysing urea from saliva and gingival exudate into ammonia in order to regulate the pH in the dental biofilm. The aim of this study was to assess the urease activity among oral bacterial species by using the rapid urease test (RUT) in a micro-plate format and to examine whether this test could be used for measuring the urease activity in site-specific supragingival dental plaque samples ex vivo. METHODS: The RUT test is based on 2% urea in peptone broth solution and with phenol red at pH 6...
May 18, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29776137/numerical-simulation-of-three-component-multiphase-flows-at-high-density-and-viscosity-ratios-using-lattice-boltzmann-methods
#12
Reza Haghani Hassan Abadi, Abbas Fakhari, Mohammad Hassan Rahimian
In this paper, we propose a multiphase lattice Boltzmann model for numerical simulation of ternary flows at high density and viscosity ratios free from spurious velocities. The proposed scheme, which is based on the phase-field modeling, employs the Cahn-Hilliard theory to track the interfaces among three different fluid components. Several benchmarks, such as the spreading of a liquid lens, binary droplets, and head-on collision of two droplets in binary- and ternary-fluid systems, are conducted to assess the reliability and accuracy of the model...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29775715/extraction-characterization-and-immunomodulatory-property-of-pectic-polysaccharide-from-pomegranate-peels-enzymatic-vs-conventional-approach
#13
Hassan Ahmadi Gavlighi, Mehdi Tabarsa, SangGuan You, Utoomporn Surayot, Maryam Ghaderi-Ghahfarokhi
Molecular characteristics, structural properties and immunostimulatory activities of polysaccharides from pomegranate peel were evaluated after 0.1 M HCl, Cellic CTec2 and buffer extractions. The isolated polysaccharides were mainly formed of neutral sugars (32.1%-51.1%) and uronic acids (19.9%-30.8%) as well as varying levels of proteins (15.0%-39.5%). Different levels of sugars including glucose (44.9%-68.1%), galactose (14.6%-19.4%), mannose (3.4%-18.1%), arabinose (3.1%-18.1%) and rhamnose (3.5-6.0%) constructed the structure of isolated polysaccharides...
May 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29775479/acute-intermittent-hypoxia-and-rehabilitative-training-following-cervical-spinal-injury-alters-neuronal-hypoxia-and-plasticity-associated-protein-expression
#14
Atiq Hassan, Breanna M Arnold, Sally Caine, Behzad M Toosi, Valerie M K Verge, Gillian D Muir
One of the most promising approaches to improve recovery after spinal cord injury (SCI) is the augmentation of spontaneously occurring plasticity in uninjured neural pathways. Acute intermittent hypoxia (AIH, brief exposures to reduced O2 levels alternating with normal O2 levels) initiates plasticity in respiratory systems and has been shown to improve recovery in respiratory and non-respiratory spinal systems after SCI in experimental animals and humans. Although the mechanism by which AIH elicits its effects after SCI are not well understood, AIH is known to alter protein expression in spinal neurons in uninjured animals...
2018: PloS One
https://www.readbyqxmd.com/read/29775110/near-point-of-convergence-in-iranian-schoolchildren-normative-values-and-associated-factors
#15
Hassan Hashemi, Payam Nabovati, Mehdi Khabazkhoob, Abbasali Yekta, Mohammad Hassan Emamian, Akbar Fotouhi
PURPOSE: To determine the distribution of near point of convergence (NPC) and its related factors in 6 to 12-year-old children. METHODS: In a cross-sectional study in 2015, the urban and rural children of Shahroud, north of Iran, were sampled. All rural schoolchildren were invited to the study, and in the urban area, we conducted random cluster sampling. Examinations included measurement of uncorrected and corrected visual acuity, manifest, subjective, and cycloplegic refraction...
May 18, 2018: Strabismus
https://www.readbyqxmd.com/read/29773141/the-application-of-the-hyper-fluorescent-sensor-in-the-real-time-detection-of-h-2-o-2-in-babesia-bovis-merozoites-in-vitro
#16
Masahito Asada, Hassan Hakimi, Shin-Ichiro Kawazu
In recent years, genetically encoded fluorescent probes have allowed a dramatic advancement in time-lapse imaging, enabling this imaging modality to be used to investigate intracellular events in several apicomplexan parasite species. In this study, we constructed a plasmid vector to stably express a genetically encoded H2 O2 sensor probe called HyPer in Babesia bovis. The HyPer-transfected parasite population was successfully developed and subjected to a time-lapse imaging analysis under in vitro culture conditions...
May 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29772299/biophenols-enzymes-%C3%AE-secretase-cholinesterases-histone-deacetylase-and-tyrosinase-inhibitors-from-olive-olea-europaea-l
#17
Syed Haris Omar, Christopher J Scott, Adam S Hamlin, Hassan K Obied
The focus of this study was on inhibition of enzymes involved in the pathogenesis Alzheimer's disease (AD) including prime amyloid beta (Aβ) producing enzyme (β-secretase: BACE-1) and disease progression enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), histone deacetylase (HDAC), and tyrosinase along with the catecholamine L-DOPA, by using olive biophenols. Here we report the strongest inhibition of BACE-1 from rutin (IC50 : 3.8 nM) followed by verbascoside (IC50 : 6.3 nM) and olive fruit extract (IC50 : 18 ng), respectively...
May 14, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29771926/evolutionary-and-genomic-analysis-of-the-caleosin-peroxygenase-clo-pxg-gene-protein-families-in-the-viridiplantae
#18
Farzana Rahman, Mehedi Hassan, Rozana Rosli, Ibrahem Almousally, Abdulsamie Hanano, Denis J Murphy
Bioinformatics analyses of caleosin/peroxygenases (CLO/PXG) demonstrated that these genes are present in the vast majority of Viridiplantae taxa for which sequence data are available. Functionally active CLO/PXG proteins with roles in abiotic stress tolerance and lipid droplet storage are present in some Trebouxiophycean and Chlorophycean green algae but are absent from the small number of sequenced Prasinophyceaen genomes. CLO/PXG-like genes are expressed during dehydration stress in Charophyte algae, a sister clade of the land plants (Embryophyta)...
2018: PloS One
https://www.readbyqxmd.com/read/29771680/factors-associated-with-time-between-using-a-drug-and-injection-initiation-among-people-who-inject-drugs-in-kermanshah-iran
#19
Mehdi Noroozi, Mohammad Hassan Farhadi, Bahram Armoon, Ali Farhoudian, Zahra Jorjoran Shushtari, Asaad Sharhani, Salah Eddin Karimi, Mohammad Sayadnasiri, Omid Rezaei, Hesam Ghiasvand
Background The transition from non-injection to injection drug use dramatically increases the risk of transmitting HIV and other blood borne infections including hepatitis B virus (HBV) and hepatitis C virus (HCV). The aim of this study was to explore factors associated with the transition from first illicit drug use to first injection among drug users. Methods Using snowball sampling and convenience sampling through needle and syringe programmes (NSPs), we recruited 500 people who inject drugs (PWID) in Kermanshah, between September and December 2014...
May 17, 2018: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29770939/biomonitoring-levels-of-airborne-metals-around-urmia-lake-using-deciduous-trees-and-evaluation-of-their-tolerance-for-greenbelt-development
#20
Amir Mohammadi, Mehdi Mokhtari, Asghar Mosleh Arani, Hassan Taghipour, Yaghoub Hajizadeh, Hossein Fallahzadeh
In the northwest of Iran, the dust of salty and toxic metals possibly caused due to drying Urmia Lake is threatening the health of surrounding communities. This study aimed to employ leaves of local deciduous trees for biomonitoring of toxic elements and to evaluate air pollution tolerance of the trees for greenbelt application. Sampling from leaves of four dominant tree species including Vitis vinifera, Juglans regia, Ulmus umbraculifera, and Popolus alba was carried out from gardens in two radial distances (5 and 10 km) around the Urmia Lake accounting for 16 sites...
May 16, 2018: Environmental Science and Pollution Research International
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