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https://www.readbyqxmd.com/read/28345563/chlamydial-eye-infections-current-perspectives
#1
Gita Satpathy, Himanshu Sekhar Behera, Nishat Hussain Ahmed
Chlamydia trachomatis, an obligate intraocular bacteria causing trachoma, adult and neonatal inclusion conjunctivitis, was the leading cause of blindness in the last century worldwide. Improvement in socioeconomic and living conditions, availability of antibiotics, and introduction of National Trachoma Control Programmes reduced the prevalence in developed countries, but it persisted in resource-poor settings of Africa and Asia, including India. In 2016, as per the WHO report, trachoma is restricted to 42 countries, causing blindness/visual impairment in ~1...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28288672/profiling-and-validation-of-individual-and-patterns-of-chlamydia-trachomatis-specific-antibody-responses-in-trachomatous-trichiasis
#2
Harry Pickering, Sarah E Burr, Tamsyn Derrick, Pateh Makalo, Hassan Joof, Richard D Hayward, Martin J Holland
BACKGROUND: Ocular Chlamydia trachomatis (Ct) infection causes trachoma, the leading infectious cause of blindness. A Ct D/UW3 proteome microarray and sera from Gambian adults with trachomatous trichiasis (TT) or healthy matched controls previously identified several novel antigens, which suggested differential recognition in adults with TT. METHODS: We re-analysed this serological microarray data using more robust microarray analysis techniques accounting for typical problems associated with highly dimensional data...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28276755/prevalence-of-trachoma-in-kano-state-nigeria-results-of-44-local-government-area-level-surveys
#3
Caleb Mpyet, Nasiru Muhammad, Mohammed Dantani Adamu, Habila Muazu, Murtala Muhammad Umar, Musa Goyol, Hadi Bala Yahaya, Uwazoeke Onyebuchi, Chris Ogoshi, Tijjani Hussaini, Sunday Isiyaku, Adamani William, Rebecca M Flueckiger, Brian K Chu, Rebecca Willis, Alexandre L Pavluck, Nicholas Olobio, Sophie Phelan, Colin Macleod, Anthony W Solomon
PURPOSE: We sought to determine the prevalence of trachoma in 44 Local Government Areas (LGAs) of Kano State, Nigeria. METHODS: A population-based prevalence survey was conducted in each Kano LGA. We used a two-stage systematic and quasi-random sampling strategy to select 25 households from each of 25 clusters in each LGA. All consenting household residents aged 1 year and above were examined for trachomatous inflammation-follicular (TF), trachomatous inflammation-intense (TI) and trichiasis...
February 28, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28187129/podoconiosis-trachomatous-trichiasis-and-cataract-in-northern-ethiopia-a-comparative-cross-sectional-study
#4
Helen Burn, Sintayehu Aweke, Tariku Wondie, Esmael Habtamu, Kebede Deribe, Saul Rajak, Stephen Bremner, Gail Davey
BACKGROUND: Rural populations in low-income countries commonly suffer from the co-morbidity of neglected tropical diseases (NTDs). Podoconiosis, trachomatous trichiasis (both NTDs) and cataract are common causes of morbidity among subsistence farmers in the highlands of northern Ethiopia. We explored whether podoconiosis was associated with cataract or trachomatous trichiasis (TT) among this population. METHODS: A comparative cross-sectional study was conducted in East Gojam region, Amhara, Ethiopia in May 2016...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28143466/long-term-outcome-of-allogeneic-cultivated-limbal-epithelial-transplantation-for-symblepharon-caused-by-severe-ocular-burns
#5
Jun Cheng, Hualei Zhai, Junyi Wang, Haoyun Duan, Qingjun Zhou
BACKGROUND: The therapeutic effects of allogeneic cultivated limbal epithelial transplantation (CLET) for symblephara at different degrees caused by ocular burns were evaluated in this study. METHODS: A series of interventional cases were involved in this retrospective study. Eighty eyes (80 patients) with symblephara underwent CLET and the success rates of surgical treatment as well as corneal conditions and risk factors for recurrent symblepharon were analyzed...
January 31, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28114364/eyelash-epilation-in-the-absence-of-trichiasis-results-of-a-population-based-prevalence-survey-in-the-western-division-of-fiji
#6
Colin Macleod, Chelsea Yalen, Robert Butcher, Umesh Mudaliar, Kinisimere Natutusau, Mere Rainima-Qaniuci, Chris Haffenden, Conall Watson, Naomi Cocks, Luisa Cikamatana, Chrissy H Roberts, Michael Marks, Eric Rafai, David C W Mabey, Mike Kama, Anthony W Solomon
BACKGROUND: The WHO definition of trachomatous trichiasis (TT) is "at least one eyelash touching the globe, or evidence of recent epilation of in-turned eyelashes", reflecting the fact that epilation is used as a self-management tool for TT. In Fiji's Western Division, a high TT prevalence (8.7% in those aged ≥15 years) was reported in a 2012 survey, yet a 2013 survey found no TT and Fijian ophthalmologists rarely see TT cases. Local anecdote suggests that eyelash epilation is a common behaviour, even in the absence of trichiasis...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28052070/identifying-patient-perceived-barriers-to-trichiasis-surgery-in-kongwa-district-tanzania
#7
Ryan J Bickley, Harran Mkocha, Beatriz Munoz, Sheila West
BACKGROUND: Trachomatous trichiasis (TT), inturned eyelashes from repeated infection with Chlamydia trachomatis, is the leading infectious cause of blindness in the world. Though surgery will correct entropion caused by trachoma, uptake of TT surgery remains low. In this case-control study, we identify barriers that prevent TT patients from receiving sight-saving surgery. METHODOLOGY/PRINCIPAL FINDINGS: Participants were selected from a database of TT cases who did (acceptors) and did not (non-acceptors) have surgery as of August 2015...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27937043/mapping-trachoma-in-the-solomon-islands-results-of-three-baseline-population-based-prevalence-surveys-conducted-with-the-global-trachoma-mapping-project
#8
Oliver Sokana, Colin Macleod, Kelvin Jack, Robert Butcher, Michael Marks, Rebecca Willis, Brian K Chu, Claude Posala, Anthony W Solomon
PURPOSE: We sought to complete the baseline trachoma map of the Solomon Islands by establishing prevalences of active trachoma and trichiasis in the provinces of Choiseul, Western, Rennell-Bellona, and Temotu. METHODS: Using the standardized methodology developed for the Global Trachoma Mapping Project, we conducted cross-sectional community-based surveys from September to November 2013. Choiseul and Western provinces were each mapped as separate evaluation units (EUs); Rennell-Bellona and Temotu were combined to form a third EU...
2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27918248/prevalence-of-trachoma-in-benishangul-gumuz-region-ethiopia-results-of-seven-population-based-surveys-from-the-global-trachoma-mapping-project
#9
Yilikal Adamu, Colin Macleod, Liknaw Adamu, Wirtu Fikru, Beyene Kidu, Aida Abashawl, Michael Dejene, Brian K Chu, Rebecca M Flueckiger, Rebecca Willis, Alexandre L Pavluck, Anthony W Solomon
PURPOSE: Trachoma is a major cause of blindness in Ethiopia, and targeted for elimination as a public health problem by the year 2020. Prevalence data are needed to plan interventions. We set out to estimate the prevalence of trachoma in each evaluation unit of grouped districts ("woredas") in Benishangul Gumuz region, Ethiopia. METHODS: We conducted seven cross-sectional community-based surveys, covering 20 woredas, between December 2013 and January 2014, as part of the Global Trachoma Mapping Project (GTMP)...
2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27918232/the-prevalence-of-trachoma-in-tigray-region-northern-ethiopia-results-of-11-population-based-prevalence-surveys-completed-as-part-of-the-global-trachoma-mapping-project
#10
Sadik Taju Sherief, Colin Macleod, Goitum Gigar, Hagos Godefay, Atakelit Abraha, Michael Dejene, Amir B Kello, Aberash Belete, Yitbarek Assefa, Rebecca Willis, Brian K Chu, Anthony W Solomon
PURPOSE: We aimed to estimate the prevalence of trachoma in each district ("woreda") of Tigray Region, Ethiopia. METHODS: We conducted 11 cross-sectional community-based surveys in evaluation units covering 34 rural woredas from January to March 2013 using the standardized methodology developed for the Global Trachoma Mapping Project. RESULTS: Teams visited 8034 households in 275 villages. A total of 28,581 consenting individuals were examined, 16,163 (56...
2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27918229/prevalence-of-and-risk-factors-for-trachoma-in-southern-nations-nationalities-and-peoples-region-ethiopia-results-of-40-population-based-prevalence-surveys-carried-out-with-the-global-trachoma-mapping-project
#11
Tesfaye Haileselassie Adera, Colin Macleod, Misganu Endriyas, Michael Dejene, Rebecca Willis, Brian K Chu, Yohannes Letamo, Tebeje Misganaw, Tamiru Mesele, Emebet Mekonnen, Alemayehu Sisay, Yeneneh Mulugeta, Wondu Alemayehu, Khumbo Kalua, Tezera Kifle Destu, Yilikal Adamu, Jennifer L Smith, Abu Beyene, Addisu Tadesse, Anthony W Solomon
PURPOSE: We sought to estimate the prevalence of trachoma at sufficiently fine resolution to allow elimination interventions to begin, where required, in the Southern Nations, Nationalities, and Peoples' Region (SNNPR) of Ethiopia. METHODS: We carried out cross-sectional population-based surveys in 14 rural zones. A 2-stage cluster randomized sampling technique was used. A total of 40 evaluation units (EUs) covering 110 districts ("woredas") were surveyed from February 2013 to May 2014 as part of the Global Trachoma Mapping Project (GTMP), using the standardized GTMP training package and methodology...
2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27918227/mapping-trachoma-in-kaduna-state-nigeria-results-of-23-local-government-area-level-population-based-prevalence-surveys
#12
Nasiru Muhammad, Caleb Mpyet, Mohammed Dantani Adamu, Adamani William, Murtala Muhammad Umar, Musa Goyol, Habila Muazu, Uwaezuoke Onyebuchi, Sunday Isiyaku, Rebecca M Flueckiger, Brian K Chu, Rebecca Willis, Alexandre L Pavluck, Abdullahi Alhassan, Nicholas Olobio, Bruce A Gordon, Anthony W Solomon
INTRODUCTION: To prepare for global elimination of trachoma by 2020, the World Health Organization (WHO) recommends mapping of trachoma at district-level to enable planning of elimination activities in affected populations. The aim of our study was to provide data on trachoma for each local government area (LGA) of Kaduna State, Nigeria, as such data were previously unavailable. METHOD: As part of the Global Trachoma Mapping Project (GTMP), a population-based cross-sectional trachoma survey was conducted in each of the 23 LGAs of Kaduna State, between May and June 2013...
2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27918223/prevalence-of-trachoma-in-niger-state-north-central-nigeria-results-of-25-population-based-prevalence-surveys-carried-out-with-the-global-trachoma-mapping-project
#13
Mohammed Dantani Adamu, Caleb Mpyet, Nasiru Muhammad, Murtala Muhammad Umar, Habila Muazu, Francisca Olamiju, Sunday Isiyaku, Uwazoeke Onyebuchi, Usman Abubakar Bosso, Adamani William, Benjamin C Nwobi, Rebecca Willis, Rebecca Mann Flueckiger, Alexandre Pavluck, Brian K Chu, Nicholas Olobio, Anthony W Solomon
PURPOSE: To determine the prevalence of trachoma in each of the 25 local government areas (LGAs) of Niger State, Nigeria. METHODS: A population-based cross-sectional survey was conducted in each Niger State LGA between March and April 2014, as part of the Global Trachoma Mapping Project (GTMP). GTMP protocols were used in planning and conduct of the surveys. Using probability proportional to size, 25 clusters were selected; in each of these clusters, 25 households were enrolled for the survey...
2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27918222/prevalence-of-trachoma-in-gambella-region-ethiopia-results-of-three-population-based-prevalence-surveys-conducted-with-the-global-trachoma-mapping-project
#14
Aida Abashawl, Colin Macleod, John Riang, Ferede Mossisa, Michael Dejene, Rebecca Willis, Rebecca M Flueckiger, Alexandre L Pavluck, Addisu Tadesse, Tesfaye Haileselassie Adera, Anthony W Solomon
PURPOSE: In Ethiopia, trachoma is a major public health problem, accounting for 11.5% of all cases of blindness. In Gambella, one of the country's most remote regions, the 2005-2006 National Survey of Blindness, Low Vision and Trachoma estimated a region-level prevalence of active trachoma of 19.1% in those aged 1-9 years. Detailed district or sub-regional level estimates are required to implement interventions. METHODS: Population-based prevalence surveys were carried out following a 2-stage cluster random sampling methodology and Global Trachoma Mapping Project protocols...
2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27893297/population-based-trachoma-mapping-in-six-evaluation-units-of-papua-new-guinea
#15
Robert Ko, Colin Macleod, David Pahau, Oliver Sokana, Drew Keys, Anthea Burnett, Rebecca Willis, Geoffrey Wabulembo, Jambi Garap, Anthony W Solomon
PURPOSE: We sought to determine the prevalence of trachomatous inflammation - follicular (TF) in children aged 1-9 years, and trachomatous trichiasis (TT) in those aged ≥15 years, in suspected trachoma-endemic areas of Papua New Guinea (PNG). METHODS: We carried out six population-based prevalence surveys using the protocol developed as part of the Global Trachoma Mapping Project. RESULTS: A total of 19,013 individuals were sampled for inclusion, with 15,641 (82...
2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27861402/long-term-results-for-entropion-repair-by-tarsal-margin-rotation-with-posterior-lamella-superadvancement
#16
David J Russell, Stuart R Seiff
PURPOSE: To report the long-term stability of tarsal margin rotation and posterior lamellar superadvancement (TMR PLS) for the repair of upper eyelid cicatricial entropion. METHODS: A retrospective chart review was performed from January 2000 through December 2014 to identify all patients who had TMR PLS at the authors' institution. Charts were reviewed for demographic information, recurrence of entropion or trichiasis, and surgical complications. Failure was defined as return of entropion...
November 15, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27846369/prevalence-of-trachoma-in-bauchi-state-nigeria-results-of-20-local-government-area-level-surveys
#17
Caleb Mpyet, Nasiru Muhammad, Mohammed Dantani Adamu, Habila Muazu, Murtala Muhammad Umar, Mohammed Abdull, Joel Alada, Musa Goyol, Uwaezuoke Onyebuchi, Francisca Olamiju, Sunday Isiyaku, Adamani William, Benjamin C Nwobi, Rebecca Willis, Rebecca Mann Flueckiger, Alex Pavluck, Brian K Chu, Nicholas Olobio, Anthony W Solomon
PURPOSE: To determine the prevalence of trachomatous inflammation - follicular (TF) and trichiasis in each of the 20 local government areas (LGAs) of Bauchi State, Nigeria. METHODS: We undertook a population-based prevalence survey in each LGA in Bauchi State, employing the Global Trachoma Mapping Project methodology. We used a 2-stage, systematic and quasi-random sampling strategy. Using probability proportional to size, we selected 25 clusters, in each of which 25 households were selected by random walk...
2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27846362/national-trachoma-assessment-in-the-lao-people-s-democratic-republic-in-2013-2014
#18
Khamphoua Southisombath, Siphet Sisalermsak, Phonesavanh Chansan, Khongsap Akkhavong, Soulasay Phommala, Susan Lewallen, Paul Courtright, Anthony W Solomon
PURPOSE: Population-based prevalence surveys were undertaken to determine whether trachoma is a public health problem in Laos requiring implementation of the SAFE strategy (surgery, antibiotics, facial cleanliness, environmental improvement). METHODS: The country was divided into 19 evaluation units (EUs), each containing a population of roughly 100,000-350,000 people. Of these, 16 were believed most likely to harbor trachoma (based on historical evidence), and were mapped using the Global Trachoma Mapping Project methods...
2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27820657/prevalence-of-and-risk-factors-for-trachoma-in-oromia-regional-state-of-ethiopia-results-of-79-population-based-prevalence-surveys-conducted-with-the-global-trachoma-mapping-project
#19
Berhanu Bero, Colin Macleod, Wondu Alemayehu, Solomon Gadisa, Ahmed Abajobir, Yilikal Adamu, Menbere Alemu, Liknaw Adamu, Michael Dejene, Addis Mekasha, Zelalem Habtamu Jemal, Damtew Yadeta, Oumer Shafi, Genet Kiflu, Rebecca Willis, Rebecca M Flueckiger, Brian K Chu, Alexandre L Pavluck, Anthony W Solomon
PURPOSE: To complete the baseline trachoma map in Oromia, Ethiopia, by determining prevalences of trichiasis and trachomatous inflammation - follicular (TF) at evaluation unit (EU) level, covering all districts (woredas) without current prevalence data or active control programs, and to identify factors associated with disease. METHODS: Using standardized methodologies and training developed for the Global Trachoma Mapping Project, we conducted cross-sectional community-based surveys from December 2012 to July 2014...
November 7, 2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27792792/economic-analysis-of-children-s-surgical-care-in-low-and-middle-income-countries-a-systematic-review-and-analysis
#20
Anthony T Saxton, Dan Poenaru, Doruk Ozgediz, Emmanuel A Ameh, Diana Farmer, Emily R Smith, Henry E Rice
BACKGROUND: Understanding the economic value of health interventions is essential for policy makers to make informed resource allocation decisions. The objective of this systematic review was to summarize available information on the economic impact of children's surgical care in low- and middle-income countries (LMICs). METHODS: We searched MEDLINE (Pubmed), Embase, and Web of Science for relevant articles published between Jan. 1996 and Jan. 2015. We summarized reported cost information for individual interventions by country, including all costs, disability weights, health outcome measurements (most commonly disability-adjusted life years [DALYs] averted) and cost-effectiveness ratios (CERs)...
2016: PloS One
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