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Hesperidin AND Review

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https://www.readbyqxmd.com/read/27774648/phytoconstituents-as-pharmacotherapeutics-in-rheumatoid-arthritis-challenges-and-scope-of-nano-submicromedicine-in-its-effective-delivery
#1
Mahfoozur Rahman, Sarwar Beg, Amita Verma, Fahad A Al Abbasi, Firoz Anwar, Sumant Saini, Sohail Akhter, Vikas Kumar
OBJECTIVES: The present review explores the therapeutic application of herbals in rheumatoid arthritis (RA) therapy, and how nano/submicromedicine can be fit in the scope of its therapeutic delivery in RA has been addressed. KEY FINDINGS: Incorporation of bioactive such as polyphenols, thymoquinone, resveratrol, hesperidin, curcumin, celastrol and gambogic acid in a dose-dependent manner showed quite high efficacy for the treatment of RA. It can be attributed to their targeting ability against various inflammatory mediators including nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF-kβ, lipoxygenase (LOXs) and arachidonic acid (AA)...
October 24, 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27248987/antioxidative-and-antidiabetic-effects-of-natural-polyphenols-and-isoflavones
#2
REVIEW
Aya Umeno, Masanori Horie, Kazutoshi Murotomi, Yoshihiro Nakajima, Yasukazu Yoshida
Many polyphenols that contain more than two phenolic hydroxyl groups are natural antioxidants and can provide health benefits to humans. These polyphenols include, for example, oleuropein, hydroxytyrosol, catechin, chlorogenic acids, hesperidin, nobiletin, and isoflavones. These have been studied widely because of their strong radical-scavenging and antioxidative effects. These effects may contribute to the prevention of diseases, such as diabetes. Insulin secretion, insulin resistance, and homeostasis are important factors in the onset of diabetes, a disease that is associated with dysfunction of pancreatic β-cells...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27146015/citrus-flavonoids-as-regulators-of-lipoprotein-metabolism-and-atherosclerosis
#3
Erin E Mulvihill, Amy C Burke, Murray W Huff
Citrus flavonoids are polyphenolic compounds with significant biological properties. This review summarizes recent advances in understanding the ability of citrus flavonoids to modulate lipid metabolism, other metabolic parameters related to the metabolic syndrome, and atherosclerosis. Citrus flavonoids, including naringenin, hesperitin, nobiletin, and tangeretin, have emerged as potential therapeutics for the treatment of metabolic dysregulation. Epidemiological studies reveal an association between the intake of citrus flavonoid-containing foods and a decreased incidence of cardiovascular disease...
July 17, 2016: Annual Review of Nutrition
https://www.readbyqxmd.com/read/27079631/effects-of-dietary-polyphenols-on-metabolic-syndrome-features-in-humans-a-systematic-review
#4
REVIEW
M J Amiot, C Riva, A Vinet
Dietary polyphenols constitute a large family of bioactive substances potential beneficial effect on metabolic syndrome (MetS). This review summarizes the results of clinical studies on patients with MetS involving the chronic supplementation of a polyphenol-rich diet, foods, extracts or with single phenolics on the features of MetS (obesity, dyslipidemia, blood pressure and glycaemia) and associated complications (oxidative stress and inflammation). Polyphenols were shown to be efficient, especially at higher doses, and there were no specific foods or extracts able to alleviate all the features of MetS...
July 2016: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/26928296/combination-of-ruscus-aculeatus-extract-hesperidin-methyl-chalcone-and-ascorbic-acid-a-comprehensive-review-of-their-pharmacological-and-clinical-effects-and-of-the-pathophysiology-of-chronic-venous-disease
#5
François-A Allaert
This paper focuses on Ruscus aculeatus extract (Ruscus extract) and its combination with hesperidin methyl chalcone (HMC) and ascorbic acid (AA), which have been safely and effectively used in CVD treatment for more than 50 years in some European countries. It presents the effects of that drug on veins and on venous hypertension, its effect on microcirculation and on lymphatics demonstrated by preclinical studies and the clinical evidence issued from clinical trials supporting its use to relieve the symptoms of venous disease...
April 2016: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/26856274/a-review-of-natural-stimulant-and-non-stimulant-thermogenic-agents
#6
REVIEW
Sidney J Stohs, Vladimir Badmaev
Obesity and overweight are major health issues. Exercise and calorie intake control are recognized as the primary mechanisms for addressing excess body weight. Naturally occurring thermogenic plant constituents offer adjunct means for assisting in weight management. The controlling mechanisms for thermogenesis offer many intervention points. Thermogenic agents can act through stimulation of the central nervous system with associated adverse cardiovascular effects and through metabolic mechanisms that are non-stimulatory or a combination thereof...
May 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/26723469/could-the-gut-microbiota-reconcile-the-oral-bioavailability-conundrum-of-traditional-herbs
#7
REVIEW
Feng Chen, Qi Wen, Jun Jiang, Hai-Long Li, Yin-Feng Tan, Yong-Hui Li, Nian-Kai Zeng
ETHNOPHARMACOLOGICAL RELEVANCE: A wealth of information is emerging about the impact of gut microbiota on human health and diseases such as cardiovascular diseases, obesity and diabetes. As we learn more, we find out the gut microbiota has the potential as new territory for drug targeting. Some novel therapeutic approaches could be developed through reshaping the commensal microbial structure using combinations of different agents. The gut microbiota also affects drug metabolism, directly and indirectly, particularly towards the orally administered drugs...
February 17, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26502950/the-role-of-hesperidin-in-cell-signal-transduction-pathway-for-the-prevention-or-treatment-of-cancer
#8
A Ahmadi, A Shadboorestan, S F Nabavi, W N Setzer, S M Nabavi
During past two decades, plant-derived bioactive compounds have been reported as novel therapeutic agents for prevention and/or mitigation of different human diseases such as cancer, inflammation, cardiovascular and neurodegenerative diseases. Hesperidin is known as one of the most common and bioactive constituents of Citrus (C) species which possesses multiple health-promotion effects. A plethora of scientific literature reported that hesperidin possesses in-vitro and in-vivo anticancer activities. In addition, there are numerous scientific evidences regarding the molecular mechanisms of anticancer activities of hesperidin and its aglycone, hesperetin...
2015: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/26381129/oxidative-stress-and-cancer-the-role-of-hesperidin-a-citrus-natural-bioflavonoid-as-a-cancer-chemoprotective-agent
#9
Amirhossein Ahmadi, Amir Shadboorestan
Cancer is the third cause of death worldwide, with complex etiology, and is defined as an uncontrolled growth of cells. A high proportion of cancer incidence and deaths are due to different environmental and genetic factors such as high body mass index, low fruit and vegetable intake, lack of physical activity, tobacco use, alcohol consumption, exposure to radiation, chronic infections, and heredity also. In addition, oxidative stress plays a crucial role in the pathophysiology of different types of cancer...
2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/26188593/protective-effects-of-flavonoids-against-microbes-and-toxins-the-cases-of-hesperidin-and-hesperetin
#10
REVIEW
Mehrdad Iranshahi, Ramin Rezaee, Hamideh Parhiz, Ali Roohbakhsh, Fatemeh Soltani
Many plants produce flavonoids as secondary metabolites. These organic compounds may be involved in the defense against plant-threatening factors, such as microbes and toxins. Certain flavonoids protect their origin source against plant pathogens, but they also exhibit potential healthy properties in human organisms. Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from the Citrus species that exhibit various biological properties, including antioxidant, antiinflammatory and anticancer effects...
September 15, 2015: Life Sciences
https://www.readbyqxmd.com/read/25675136/health-promoting-effects-of-the-citrus-flavanone-hesperidin
#11
Chaoyun Li, Hermann Schluesener
Hesperidin, a member of the flavanone group of flavonoids, can be isolated in large amounts from the rinds of some citrus species. Considering the wide range of pharmacological activities and widespread application of hesperidin, this paper reviews preclinical and clinical trials of hesperidin and its related compounds, including their occurrence, pharmacokinetics, and some marketed products available. Preclinical studies and clinical trials demonstrated therapeutical effects of hesperidin and its aglycone hesperetin in various diseases, such as neurological disorders, psychiatric disorders and cardiovascular diseases and others, due to its anti-inflammatory, antioxidant, lipid-lowering and insulin-sensitizing properties...
February 12, 2015: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/25625242/molecular-mechanisms-behind-the-biological-effects-of-hesperidin-and-hesperetin-for-the-prevention-of-cancer-and-cardiovascular-diseases
#12
REVIEW
Ali Roohbakhsh, Hamideh Parhiz, Fatemeh Soltani, Ramin Rezaee, Mehrdad Iranshahi
Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species that have various biological properties, particularly those for the prevention of cancer and cardiovascular diseases. Studies have shown both anti-cancer and cancer chemopreventive effects for Hsd and Hst. Cancer chemopreventive properties of Hsd and Hst are mainly associated with their antioxidant, radical scavenging and anti-inflammatory activities. In addition, Hsd and Hst interfere at different stages of cancer. Unlike conventional anti-cancer drugs, Hsd and Hst inhibit tumor growth by targeting multiple cellular protein targets at the same time, including caspases, Bcl-2 (B-cell lymphoma 2) and Bax (Bcl-2 associated X protein) for the induction of apoptosis, and COX-2 (cyclooxygenase-2), MMP-2 (matrix metalloproteinase-2) and MMP-9 for the inhibition of angiogenesis and metastasis...
March 1, 2015: Life Sciences
https://www.readbyqxmd.com/read/25547100/emerging-potential-of-citrus-flavanones-as-an-antioxidant-in-diabetes-and-its-complications
#13
REVIEW
Malvika Sharma, Nadeem Akhtar, Kumar Sambhav, Ganesh Shete, Arvind K Bansal, Shyam S Sharma
A proper balance between oxidants and antioxidants is necessary in maintaining health and longevity. Alterations in this balance may result in oxidative stress causing functional disorders and diseases. Oxidative stress is considered to play a vital role in the pathogenesis of diabetes and its complications. Flavanones and flavanones-rich botanical extracts have been a subject of great interest for scientific research. Citrus flavanones like naringin and hesperidin exert a variety of biological activities such as anti-oxidant, anti-inflammatory, antihyperglycemic, anti-apoptotic etc...
2015: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/25496274/emerging-potential-of-citrus-flavanones-as-an-antioxidant-in-diabetes-and-its-complications
#14
Malvika Sharma, Nadeem Akhtar, Kumar Sambhav, Ganesh Shete, Arvind K Bansal, Shyam S Sharma
A proper balance between oxidants and antioxidants is necessary in maintaining health and longevity. Alterations in this balance may result in oxidative stress causing functional disorders and diseases. Oxidative stress is considered to play a vital role in the pathogenesis of diabetes and its complications. Flavanones and flavanones-rich botanical extracts have been a subject of great interest for scientific research. Citrus flavanones like naringin and hesperidin exert a variety of biological activities such as anti-oxidant, anti-inflammatory, anti-hyperglycemic, anti-apoptotic etc...
December 9, 2014: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/25394264/antioxidant-and-anti-inflammatory-properties-of-the-citrus-flavonoids-hesperidin-and-hesperetin-an-updated-review-of-their-molecular-mechanisms-and-experimental-models
#15
REVIEW
Hamideh Parhiz, Ali Roohbakhsh, Fatemeh Soltani, Ramin Rezaee, Mehrdad Iranshahi
Inflammation and oxidative stress are two major causes of various life-threatening diseases. Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species that have numerous biological properties, particularly antioxidant and anti-inflammatory. New findings showed that the antioxidant activity of Hsd/Hst was not only limited to its radical scavenging activity, but it augmented the antioxidant cellular defenses via the ERK/Nrf2 signaling pathway as well. Various in vitro and in vivo studies have been conducted to evaluate Hsd, its metabolites, or its synthetic derivatives at reducing inflammatory targets including NF-κB, iNOS, and COX-2, and the markers of chronic inflammation...
March 2015: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/25176345/hesperidin-potentiates-ghrelin-signaling
#16
REVIEW
Hajime Suzuki, Akihiro Asakawa, Namiko Kawamura, Takakazu Yagi, Akio Inui
Hesperidin, a flavanone glycoside consisting of the flavone hesperitin bound to the disaccharide rutinose, is found in highly nutritious foods, such as oranges, tangelos, tangerines, grapefruits, and other citrus fruits. Exogenous hesperidin has been shown to influence a wide variety of biological functions, including induction of apoptosis and suppression of proliferation in human cancer cells; inhibition of tumor development in various tissues; and expression of antibacterial, antiviral, and antifungal activities...
2014: Recent Patents on Food, Nutrition & Agriculture
https://www.readbyqxmd.com/read/25109791/neuropharmacological-properties-and-pharmacokinetics-of-the-citrus-flavonoids-hesperidin-and-hesperetin-a-mini-review
#17
REVIEW
Ali Roohbakhsh, Hamideh Parhiz, Fatemeh Soltani, Ramin Rezaee, Mehrdad Iranshahi
Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species that have various biological properties. Over the past decade, a large number of papers have been published regarding the biological activities of these compounds and their molecular mechanisms. In this paper, we reviewed the neuropharmacology of Hsd and Hst as a recently emerged topic that has not been addressed in the past. Some of molecular targets and signaling pathways for neuropharmacological effects of Hst and Hsd, including antidepressant, neuroprotective and the effects of Hsd/Hst on memory, have also been included in the review...
September 15, 2014: Life Sciences
https://www.readbyqxmd.com/read/23642183/natural-polyphenols-in-the-management-of-major-depression
#18
REVIEW
Lokesh Pathak, Yadvendra Agrawal, Ashish Dhir
INTRODUCTION: Natural polyphenols, the non-essential micronutrients, found in array of plant products, are known to affect various physiological and biochemical functions in the body. Studies have shown the protective effect of these polyphenols in different neurological and mental disorders. These polyphenols modulate monoaminergic neurotransmission in the brain and thus possess antidepressant-like activity at least in animal models of depression. AREAS COVERED: The present review discusses the use of these natural polyphenols in the treatment of major depression...
July 2013: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/23417730/anti-inflammatory-properties-of-orange-juice-possible-favorable-molecular-and-metabolic-effects
#19
REVIEW
Raquel Cristina Lopes Assis Coelho, Helen Hermana M Hermsdorff, Josefina Bressan
The low-grade inflammation has been recognized as the link between adiposity and the risk of chronic metabolic disorders. Thus, increased concentrations of inflammatory markers, such as interleukins and tumor necrosis factor alpha have been found in obese individuals. In turn, diet can positively or negatively influence on the risk of chronic metabolic diseases by modulating the inflammatory status. In this context, orange juice consumption can play a role in modulation of inflammatory markers through bioactive compounds, such as the flavonoids (hesperidin, naringenin)...
March 2013: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/23254473/citrus-flavonoids-and-lipid-metabolism
#20
REVIEW
Julia M Assini, Erin E Mulvihill, Murray W Huff
PURPOSE OF REVIEW: Citrus flavonoids are polyphenolic compounds with powerful biological properties. This review aims to summarize recent advances towards understanding the ability of citrus flavonoids to regulate lipid metabolism and other metabolic parameters relevant to the metabolic syndrome, type 2 diabetes and cardiovascular disease. RECENT FINDINGS: Citrus flavonoids, including naringenin, hesperidin, nobiletin and tangeretin, have emerged as promising therapeutic agents for the treatment of metabolic dysregulation...
February 2013: Current Opinion in Lipidology
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