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Joseph herman

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https://www.readbyqxmd.com/read/28065427/systematic-review-on-the-treatment-of-isolated-local-recurrence-of-pancreatic-cancer-after-surgery-re-resection-chemoradiotherapy-and-sbrt
#1
REVIEW
Vincent P Groot, Hjalmar C van Santvoort, Steffi J E Rombouts, Jeroen Hagendoorn, Inne H M Borel Rinkes, Marco van Vulpen, Joseph M Herman, Christopher L Wolfgang, Marc G Besselink, I Quintus Molenaar
BACKGROUND: The majority of patients who have undergone a pancreatic resection for pancreatic cancer develop disease recurrence within two years. In around 30% of these patients, isolated local recurrence (ILR) is found. The aim of this study was to systematically review treatment options for this subgroup of patients. METHODS: A systematic search was performed in PubMed, Embase and the Cochrane Library. Studies reporting on the treatment of ILR after initial curative-intent resection of primary pancreatic cancer were included...
January 3, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28048848/mo-fg-campus-jep3-04-feasibility-study-of-real-time-ultrasound-monitoring-for-abdominal-stereotactic-body-radiation-therapy
#2
Lin Su, Sook Kien Ng, Ying Zhang, Tianlong Ji, Iulian Iordachita, Joseph Herman, John Wong, H Tutkun Sen, Peter Kazanzides, Muyinatu A Lediju Bell, Kai Ding
PURPOSE: Ultrasound is ideal for real-time monitoring in radiotherapy with high soft tissue contrast, non-ionization, portability, and cost effectiveness. Few studies investigated clinical application of real-time ultrasound monitoring for abdominal stereotactic body radiation therapy (SBRT). This study aims to demonstrate the feasibility of real-time monitoring of 3D target motion using 4D ultrasound. METHODS: An ultrasound probe holding system was designed to allow clinician to freely move and lock ultrasound probe...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28035921/young-to-middle-aged-dogs-with-high-amyloid-%C3%AE-levels-in-cerebrospinal-fluid-are-impaired-on-learning-in-standard-cognition-tests
#3
Herman Borghys, Bianca Van Broeck, Deborah Dhuyvetter, Tom Jacobs, Katja de Waepenaert, Tim Erkens, Melissa Brooks, Sandy Thevarkunnel, Joseph A Araujo
Understanding differences in Alzheimer's disease biomarkers before the pathology becomes evident can contribute to an improved understanding of disease pathogenesis and treatment. A decrease in amyloid-β (Aβ)42 in cerebrospinal fluid (CSF) is suggested to be a biomarker for Aβ deposition in brain. However, the relevance of CSF Aβ levels prior to deposition is not entirely known. Dogs are similar to man with respect to amyloid-β protein precursor (AβPP)-processing, age-related amyloid plaque deposition, and cognitive dysfunction...
December 30, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27993573/clinical-utility-of-a-precision-medicine-test-evaluating-outpatients-with-suspected-obstructive-coronary-artery-disease
#4
Joseph A Ladapo, Matt Budoff, David Sharp, Michael Zapien, Lin Huang, Bruce Maniet, Lee Herman, Mark Monane
BACKGROUND: Identifying patients with obstructive coronary artery disease can be challenging for primary care physicians. Advances in precision medicine may help augment clinical tools and redefine the paradigm for evaluating coronary artery disease in the outpatient setting. A blood-based age/sex/gene expression score (ASGES) incorporating key features of precision medicine has shown clinical validity with a 96% negative predictive value and 89% sensitivity in estimating a symptomatic patient's current likelihood of obstructive coronary artery disease...
December 16, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27965841/behavioral-activation-group-therapy-for-reducing-depressive-symptoms-and-improving-quality-of-life-a-feasibility-study
#5
Zainab Samaan, Brittany B Dennis, Lindsay Kalbfleisch, Herman Bami, Laura Zielinski, Monica Bawor, Kathryn Litke, Kathleen McCabe, Jeff Whattam, Laura Garrick, Laura O'Neill, Terri Ann Tabak, Scott Simons, Sandra Chalmers, Brenda Key, Meredith Vanstone, Feng Xie, Gordon Guyatt, Lehana Thabane
BACKGROUND: Depression is associated with a loss of productivity and noticeable personal, social, and economic decline; it affects more than 350 million people worldwide. Behavioral activation (BA), derived from cognitive behavioral therapy, has drawn increasingly more interest as a means of treatment for major depressive disorder due to its relative cost-effectiveness and efficacy. In this study, we disseminate findings from a feasibility study evaluating barriers to implementing a group BA program for major depressive disorder...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27812973/behavioral-health-and-primary-care-integration-in-ohio-s-psychiatry-residency-training
#6
Eric Reed, Dushka Crane, Dale Svendsen, Lon Herman, Brian Evans, Julie Niedermier, William Resch, Robert Ronis, Joseph Varley, Randy Welton
No abstract text is available yet for this article.
December 2016: Academic Psychiatry
https://www.readbyqxmd.com/read/27797995/changes-to-physician-processing-times-in-response-to-clinic-congestion-and-patient-punctuality-a-retrospective-study
#7
Chester G Chambers, Maqbool Dada, Shereef Elnahal, Stephanie Terezakis, Theodore DeWeese, Joseph Herman, Kayode A Williams
OBJECTIVES: We examine interactions among 3 factors that affect patient waits and use of overtime in outpatient clinics: clinic congestion, patient punctuality and physician processing rates. We hypothesise that the first 2 factors affect physician processing rates, and this adaptive physician behaviour serves to reduce waiting times and the use of overtime. SETTING: 2 urban academic clinics and an affiliated suburban clinic in metropolitan Baltimore, Maryland, USA...
October 18, 2016: BMJ Open
https://www.readbyqxmd.com/read/27787294/assessing-the-financial-burden-associated-with-treatment-options-for-resectable-pancreatic-cancer
#8
Marcelo Cerullo, Faiz Gani, Sophia Y Chen, Joseph K Canner, Joseph M Herman, Daniel Laheru, Timothy M Pawlik
OBJECTIVE: The aim of this study is to assess the financial burden associated with treatment options for resectable pancreatic cancer. BACKGROUND: As the volume of cancer care increases in the United States, there is growing interest among both clinicians and policy-makers to reduce its financial impact on the healthcare system. However, costs relative to the survival benefit for differing treatment modalities used in practice have not been described. METHODS: Patients undergoing resection for pancreatic cancer were identified in the Truven Health MarketScan database...
October 25, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27782730/comparison-of-quantitative-y-90-spect-and-non-time-of-flight-pet-imaging-in-post-therapy-radioembolization-of-liver-cancer
#9
Jianting Yue, Thibault Mauxion, Diane K Reyes, Martin A Lodge, Robert F Hobbs, Xing Rong, Yinfeng Dong, Joseph M Herman, Richard L Wahl, Jean-François H Geschwind, Eric C Frey
PURPOSE: Radioembolization with yttrium-90 microspheres may be optimized with patient-specific pretherapy treatment planning. Dose verification and validation of treatment planning methods require quantitative imaging of the post-therapy distribution of yttrium-90 (Y-90). Methods for quantitative imaging of Y-90 using both bremsstrahlung SPECT and PET have previously been described. The purpose of this study was to compare the two modalities quantitatively in humans. METHODS: Calibration correction factors for both quantitative Y-90 bremsstrahlung SPECT and a non-time-of-flight PET system without compensation for prompt coincidences were developed by imaging three phantoms...
October 2016: Medical Physics
https://www.readbyqxmd.com/read/27742076/the-rise-and-fall-of-the-d-serine-mediated-gliotransmission-hypothesis
#10
REVIEW
Herman Wolosker, Darrick T Balu, Joseph T Coyle
d-Serine modulates N-methyl d-aspartate receptors (NMDARs) and regulates synaptic plasticity, neurodevelopment, and learning and memory. However, the primary site of d-serine synthesis and release remains controversial, with some arguing that it is a gliotransmitter and others defining it as a neuronal cotransmitter. Results from several laboratories using different strategies now show that the biosynthetic enzyme of d-serine, serine racemase (SR), is expressed almost entirely by neurons, with few astrocytes appearing to contain d-serine...
November 2016: Trends in Neurosciences
https://www.readbyqxmd.com/read/27629550/whole-exome-sequencing-in-families-with-cll-detects-a-variant-in-integrin-%C3%AE-2-associated-with-disease-susceptibility
#11
LETTER
Lynn R Goldin, Mary L McMaster, Melissa Rotunno, Sarah E M Herman, Kristine Jones, Bin Zhu, Joseph Boland, Laurie Burdett, Belynda Hicks, Sarangan Ravichandran, Brian T Luke, Meredith Yeager, Laura Fontaine, Alisa M Goldstein, Stephen J Chanock, Margaret A Tucker, Adrian Wiestner, Gerald Marti, Neil E Caporaso
No abstract text is available yet for this article.
November 3, 2016: Blood
https://www.readbyqxmd.com/read/27577874/fine-mapping-novel-loci-identification-and-snp-association-transferability-in-a-genome-wide-association-study-of-qrs-duration-in-african-americans
#12
Daniel S Evans, Christy L Avery, Mike A Nalls, Guo Li, John Barnard, Erin N Smith, Toshiko Tanaka, Anne M Butler, Sarah G Buxbaum, Alvaro Alonso, Dan E Arking, Gerald S Berenson, Joshua C Bis, Steven Buyske, Cara L Carty, Wei Chen, Mina K Chung, Steven R Cummings, Rajat Deo, Charles B Eaton, Ervin R Fox, Susan R Heckbert, Gerardo Heiss, Lucia A Hindorff, Wen-Chi Hsueh, Aaron Isaacs, Yalda Jamshidi, Kathleen F Kerr, Felix Liu, Yongmei Liu, Kurt K Lohman, Jared W Magnani, Joseph F Maher, Reena Mehra, Yan A Meng, Solomon K Musani, Christopher Newton-Cheh, Kari E North, Bruce M Psaty, Susan Redline, Jerome I Rotter, Renate B Schnabel, Nicholas J Schork, Ralph V Shohet, Andrew B Singleton, Jonathan D Smith, Elsayed Z Soliman, Sathanur R Srinivasan, Herman A Taylor, David R Van Wagoner, James G Wilson, Taylor Young, Zhu-Ming Zhang, Alan B Zonderman, Michele K Evans, Luigi Ferrucci, Sarah S Murray, Gregory J Tranah, Eric A Whitsel, Alex P Reiner, Nona Sotoodehnia
The electrocardiographic QRS duration, a measure of ventricular depolarization and conduction, is associated with cardiovascular mortality. While genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with QRS duration at 22 loci among those of European descent, the genetic architecture of QRS duration in non-European populations is largely unknown. We therefore performed a GWAS meta-analysis of QRS duration in 13,031 African Americans from ten cohorts and a transethnic GWAS meta-analysis with additional results from populations of European descent...
August 29, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27576360/computed-tomography-imaging-assessment-of-postexternal-beam-radiation-changes-of-the-liver
#13
Michael Lock, Ashkan A Malayeri, Omar Y Mian, Nina A Mayr, Joseph M Herman, Simon S Lo
Radiation is being used for patients with primary and secondary liver cancers, as a rapidly evolving treatment. However, postradiation imaging changes of the liver are not well understood and therefore challenging to interpret. Distinguishing normal radiation changes from residual or recurrent disease is difficult. Size and contrast enhancement have been used to guide interpretation and clinical recommendations, but normal radiation changes can make interpretation difficult and are not accounted for in available guidelines...
December 2016: Future Oncology
https://www.readbyqxmd.com/read/27552809/patient-reported-outcomes-of-a-multicenter-phase-2-study-investigating-gemcitabine-and-stereotactic-body-radiation-therapy-in-locally-advanced-pancreatic-cancer
#14
Avani D Rao, Elizabeth A Sugar, Daniel T Chang, Karyn A Goodman, Amy Hacker-Prietz, Lauren M Rosati, Laurie Columbo, Eileen O'Reilly, George A Fisher, Lei Zheng, Jonathan S Pai, Mary E Griffith, Daniel A Laheru, Christine A Iacobuzio-Donahue, Christopher L Wolfgang, Albert Koong, Joseph M Herman
PURPOSE: We previously reported clinical outcomes and physician-reported toxicity of gemcitabine and hypofractionated stereotactic body radiation therapy (SBRT) in locally advanced pancreatic cancer (LAPC). Here we prospectively investigate the impact of gemcitabine and SBRT on patient-reported quality of life (QoL). METHODS AND MATERIALS: Forty-nine LAPC patients received 33 Gy SBRT (6.6 Gy daily fractions) upfront or after ≤3 doses of gemcitabine (1000 mg/m(2)) followed by gemcitabine until progression...
November 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27520932/neuroendocrine-tumor-liver-metastases-treated-with-yttrium-90-radioembolization
#15
Katherine Y Fan, Aaron T Wild, Vivek G Halappa, Rachit Kumar, Susannah Ellsworth, Mark Ziegler, Tanu Garg, Lauren M Rosati, Zheng Su, Amy Hacker-Prietz, Timothy M Pawlik, David P Cosgrove, Kelvin K Hong, Ihab R Kamel, Jean-Francois Geschwind, Joseph M Herman
OBJECTIVE: Yttrium-90 (Y-90) radioembolization is an emerging treatment option for unresectable neuroendocrine liver metastases (NELM). However, the data regarding this treatment are currently limited. This study evaluates the efficacy and tolerability of Y-90 radioembolization and identifies prognostic factors for radiographic response and survival. METHODS AND MATERIALS: Thirty-eight patients underwent Y-90 radioembolization for NELM at our institution between April 2004 and February 2012...
September 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27495850/predictors-of-improved-survival-for-patients-with-retroperitoneal-sarcoma
#16
Katherine Giuliano, Neeraja Nagarajan, Joseph K Canner, Christopher L Wolfgang, Trinity Bivalacqua, Stephanie Terezakis, Joseph Herman, Eric B Schneider, Nita Ahuja
BACKGROUND: Retroperitoneal sarcomas are rare tumors that can be locally aggressive with high rates of recurrence. Given that data on survival in patients with retroperitoneal sarcomas are conflicting, we sought to use a nationwide cancer database to identify factors associated with survival in patients with retroperitoneal sarcomas. METHODS: The Surveillance, Epidemiology, and End Results database was utilized to identify patients with retroperitoneal sarcomas from 2002 to 2012...
December 2016: Surgery
https://www.readbyqxmd.com/read/27488614/an-ovarian-bioreactor-for-in-vitro-culture-of-the-whole-bovine-ovary-a-preliminary-report
#17
Matthew R Zanotelli, Joseph D Henningsen, Patrick M Hopkins, Aaron P Dederich, Tessa Herman, Tracy J Puccinelli, Sana M Salih
BACKGROUND: Improved cancer therapeutics and enhanced cancer survivorship have emphasized the severe long-term side effects of chemotherapy. Specifically, studies have linked many chemotherapy agents with primary ovarian insufficiency, although an exact insult model has not yet been determined. To investigate and ultimately solve this problem, a novel device for extended study of mammalian ovaries in vitro was developed. METHODS: A bioreactor was fabricated for bovine ovarian culture that provides intravascular delivery of media to the ovary through isolation and cannulation of a main ovarian artery branch...
August 4, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27474791/does-residual-microscopic-disease-after-chemoradiotherapy-for-locally-advanced-rectal-cancer-translate-into-good-clinical-outcome
#18
Ravit Geva, Herman Davidovics, Slava Soyfer, Sharon Pelles-Avraham, Joseph M Klausner, Moshe Inbar, Hagit Tulchinsky
AIM: This study aimed to assess the progression-free and overall survival of patients with residual microscopic disease following neoadjuvant chemoradiation and rectal resection for locally advanced rectal cancer. METHODS: Two-hundred and thirty-four consecutive rectal cancer patients who had neoadjuvant chemoradiotherapy followed by radical resection (5/2000-4/2012) were divided according to pathologic tumor response: residual microscopic disease (MIC), complete response (pCR), and partial/no response (nonCR)...
July 30, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27422366/microglial-acid-sensing-regulates-carbon-dioxide-evoked-fear
#19
Lauren Larke Vollmer, Sriparna Ghosal, Jennifer L McGuire, Rebecca L Ahlbrand, Ke-Yong Li, Joseph M Santin, Christine A Ratliff-Rang, Luis G A Patrone, Jennifer Rush, Ian P Lewkowich, James P Herman, Robert W Putnam, Renu Sah
BACKGROUND: Carbon dioxide (CO2) inhalation, a biological challenge and pathologic marker in panic disorder, evokes intense fear and panic attacks in susceptible individuals. The molecular identity and anatomic location of CO2-sensing systems that translate CO2-evoked fear remain unclear. We investigated contributions of microglial acid sensor T cell death-associated gene-8 (TDAG8) and microglial proinflammatory responses in CO2-evoked behavioral and physiological responses. METHODS: CO2-evoked freezing, autonomic, and respiratory responses were assessed in TDAG8-deficient ((-/-)) and wild-type ((+/+)) mice...
October 1, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27422109/acr-appropriateness-criteria%C3%A2-borderline-and-unresectable-pancreas-cancer
#20
REVIEW
William Small, John P Hayes, W Warren Suh, May Abdel-Wahab, Ross A Abrams, Nilofer Azad, Prajnan Das, Jadranka Dragovic, Karyn A Goodman, Salma K Jabbour, William E Jones, Andre A Konski, Albert C Koong, Rachit Kumar, Percy Lee, Timothy M Pawlik, Joseph M Herman
The American College of Radiology Appropriateness Criteria® are evidence-based guidelines for specific clinical conditions that are reviewed every 3 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer-reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances where evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment...
July 2016: Oncology (Williston Park, NY)
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