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JOURNAL ARTICLE
Pierleone Lucatelli, Simone Ciaglia, Bianca Rocco, Gianluca De Rubeis, Guido Bolognesi, Elio Damato, Mario Corona, Pier Giorgio Nardis, Alessandro Cannavale, Paolo Ricci, Carlo Catalano
OBJECTIVES: To demonstrate in vivo redistribution of the blood flow towards HCC's lesions by utilizing two-dimensional perfusion angiography in b-TACE procedures. MATERIAL AND METHODS: In total, 30 patients with 35 HCC nodules treated in the period between January 2019 and November 2021. For each patient, a post-processing software leading to a two-dimensional perfusion angiography was applied on each angiography performed via balloon microcatheter, before and after inflation...
April 18, 2024: La Radiologia Medica
#2
JOURNAL ARTICLE
Maximilian R Stammnitz, Kevin Gori, Elizabeth P Murchison
Tasmanian devils are endangered by a transmissible cancer known as Tasmanian devil facial tumour 1 (DFT1). A 2020 study by Patton et al . ( Science 370 , eabb9772 (doi:10.1126/science.abb9772)) used genome data from DFT1 tumours to produce a dated phylogenetic tree for this transmissible cancer lineage, and thence, using phylodynamics models, to estimate its epidemiological parameters and predict its future trajectory. It concluded that the effective reproduction number for DFT1 had declined to a value of one, and that the disease had shifted from emergence to endemism...
April 2024: Royal Society Open Science
#3
JOURNAL ARTICLE
Karolos-Philippos Pissas, Stefan Gründer, Yuemin Tian
Fast growing solid tumors are frequently surrounded by an acidic microenvironment. Tumor cells employ a variety of mechanisms to survive and proliferate under these harsh conditions. In that regard, acid-sensitive membrane receptors constitute a particularly interesting target, since they can affect cellular functions through ion flow and second messenger cascades. Our knowledge of these processes remains sparse, however, especially regarding medulloblastoma, the most common pediatric CNS malignancy. In this study, using RT-qPCR, whole-cell patch clamp, and Ca2+ -imaging, we uncovered several ion channels and a G protein-coupled receptor, which were regulated directly or indirectly by low extracellular pH in DAOY and UW228 medulloblastoma cells...
April 16, 2024: Pflügers Archiv: European Journal of Physiology
#4
JOURNAL ARTICLE
Allan Hiroshi de Araujo Ono, Aécio Rubens Dias Pereira Filho, Fernando Flores de Araujo, Raphael Marthus Marcon, Alexandre Fogaça Cristante, Tarcisio Eloy de Pessoa Barros Filho
The surgical approach to the lumbosacral spine has been the subject of experimental and scientific anatomical studies since the Hippocratic era. However, it was in the 20th century that, with the evolution of asepsis and antibiotic therapy, spine surgery began to evolve at breakneck speed, and the various possibilities of access roads became objects of development and discussion. As a result, pathologies of the lumbosacral spine can be accessed in different ways and positions, from the traditional posterior approach in the prone position to the anterior, oblique, lateral, and endoscopic approaches...
April 2024: Revista Brasileira de Ortopedia
#5
JOURNAL ARTICLE
Qurat-Ul-Ain Virani, Zanib Javed, Muhammad Shahzad Shamim
Assessing treatment response is extremely important in management of brain tumours. Response assessment in neuro-oncology (RANO) was introduced in 2008 for the purpose of making recommendations for it by addressing and countering the limitations in previously reported response criteriae. Subsequently, multiple RANO working groups have been formed to cater to different tumour types and to update their previous recommendations to counter the limitations in their criteria. Herein we have a summarized list of RANO criteria for adult brain tumours...
March 2024: JPMA. the Journal of the Pakistan Medical Association
#6
JOURNAL ARTICLE
Abigail Albutt, John Hardman, Lynn McVey, Chinasa Odo, Vinidh Paleri, Jo Patterson, Sarah Webb, Nikki Rousseau, Ian Kellar, Rebecca Randell
INTRODUCTION: Between 2009/2010 and 2019/2020, England witnessed an increase in suspected head and neck cancer (sHNC) referrals from 140 to 404 patients per 100 000 population. 1 in 10 patients are not seen within the 2-week target, contributing to patient anxiety. We will develop a pathway for sHNC referrals, based on the Head and Neck Cancer Risk Calculator. The evolution of a patient-reported symptom-based risk stratification system to redesign the sHNC referral pathway (EVEREST-HN) Programme comprises six work packages (WPs)...
April 5, 2024: BMJ Open
#7
REVIEW
Eghosa Morgan, John I Nwadiokwu, Samuel Olowo, Ezemwenghian Morgan, Edward Poluyi
Surgically treated intracranial infections are among the common disease entities seen in neurosurgical practice. Several microbiological agents such as bacteria and fungi have been identified as responsible for intracranial infection. It affects all age groups, though microbial agents and risk factors vary with age. Presentation is non-specific and it requires a high index of suspicion, especially with a background febrile illness such as in the setting of poorly-treated meningitis and immunosuppressive conditions such as retroviral illness...
February 29, 2024: West African Journal of Medicine
#8
JOURNAL ARTICLE
Margaux Mekkan-Bouv Hez, Lea Derbey, Louis de Mestier, Lorenzo D, Thomas Walter, M Perrier, Guillaume Cadiot, B Goichot, M Pracht, A Lièvre, Romain Coriat, Sophie Valancot, Rosine Guimbaud, Nicolas Carrere, O Bacoeur-Ouzillou, G Belleannée, Denis Smith, S Laboureau, Sophie Hescot, Catherine Julie, M P Teissier, Jeremie Thereaux, A Ferru, C Evrard, Muriel Mathonnet, Niki Christou
INTRODUCTION: Duodenal neuroendocrine tumours (D-NETs) have a low incidence; however, their diagnosis has been increasing. Features such as tumour location, size, type, histological grade, and stage were used to adapt the treatment to either endoscopic (ER) or surgical (SR) resections. There is no consensus regarding the definitive treatment. The authors' study aimed to describe the management of non-metastatic, well-differentiated D-NETs in France and its impact on patient survival. METHODS: A registry-based multicenter study using prospectively collected data between 2000 and 2019, including all patients managed for non-metastatic G1 and G2 D-NETs, was conducted in the GTE group...
April 3, 2024: International Journal of Surgery
#9
Yassine El Qadiri, Oussama El Adaoui, Yasser El Andaloussi, Ahmed Reda Haddoun, Driss Bennouna, Mustapha Fadili
INTRODUCTION AND IMPORTANCE: Aggressive fibromatosis or desmoid tumour is a rare soft tissue tumour that develops from supporting tissues and fascia. Although benign, fibromatosis is a tumour that can be locally invasive, and surgical treatment is often difficult. The interest of this observation is to show the particular characteristics of desmoid tumours: the frequency, the major difficulties of excision and the role of adjuvant treatment in the management of these tumours. CASE PRESENTATION: The patient was 27 years old male, and had a pathological history of a recurrent desmoid tumour on the dorsal surface of the right foot, which had been present for 10 years, had been operated on 5 times and could not be completely removed...
February 12, 2024: International Journal of Surgery Case Reports
#10
REVIEW
Shuaixi Yang, Yuhang Wang, Jiachi Jia, Yingshuai Fang, Yabing Yang, Weitang Yuan, Junhong Hu
Macrophages, as pivotal cells within the tumour microenvironment, significantly influence the impact of and reactions to treatments for solid tumours. The rapid evolution of bioengineering technology has revealed the vast potential of engineered macrophages in immunotherapy, disease diagnosis, and tissue engineering. Given this landscape, the goal of harnessing and innovating macrophages as a novel strategy for solid tumour immunotherapy cannot be overstated. The diverse strategies for engineered macrophages in the realm of cancer immunotherapy, encompassing macrophage drug delivery systems, chimeric antigen receptor macrophage therapy, and synergistic treatment approaches involving bacterial outer membrane vesicles and macrophages, are meticulously examined in this review...
April 1, 2024: Cell Death & Disease
#11
JOURNAL ARTICLE
O Alkhatib, T Miles, R P Jones, R Mair, R Palmer, H Winter, F D McDermott
Genomics is a crucial part of managing surgical disease. This review focuses on some of the genomic advances that are available now and looks to the future of their application in surgical practice. Whole-genome sequencing enables unbiased coverage across the entire human genome of approximately three billion base pairs. Newer technologies, such as those that permit long-read sequence analysis, provide additional information in longer phased fragment and base pair epigenomic (methylomic) data. Whole-genome sequencing is currently available in England for cancers in children, teenagers and young adults, central nervous system tumours, sarcoma and haematological malignancies...
April 2024: Annals of the Royal College of Surgeons of England
#12
EDITORIAL
Eric Santoni-Rugiu
No abstract text is available yet for this article.
March 28, 2024: Thorax
#13
JOURNAL ARTICLE
Alba García Vázquez, Namiko Mitarai, Liselotte Jauffred
Genetic fluctuation during range expansion is a key process driving evolution. When a bacterial population is expanding on a 2D surface, random fluctuations in the growth of the pioneers at the front line cause a strong demixing of genotypes. Even when there is no selective advantage, sectors of low genetic diversity are formed. Experimental studies of range expansions in surface-attached colonies of fluorescently labelled micro-organisms have contributed significantly to our understanding of fundamental evolutionary dynamics...
January 2024: ISME Commun
#14
JOURNAL ARTICLE
E G M van Geffen, J M A Langhout, S J A Hazen, T C Sluckin, S van Dieren, G L Beets, R G H Beets-Tan, W A A Borstlap, J W A Burger, K Horsthuis, M P W Intven, A G J Aalbers, K Havenga, A W K S Marinelli, J Melenhorst, J Nederend, H M U Peulen, H J T Rutten, W H Schreurs, J B Tuynman, C Verhoef, J H W de Wilt, C A M Marijnen, P J Tanis, M Kusters, On Behalf Of The Dutch Snapshot Research Group
BACKGROUND: In the Netherlands, use of neoadjuvant radiotherapy for rectal cancer declined after guideline revision in 2014. This decline is thought to affect the clinical nature and treatability of locally recurrent rectal cancer (LRRC). Therefore, this study compared two national cross-sectional cohorts before and after the guideline revision with the aim to determine the changes in treatment and survival of LRRC patients over time. METHODS: Patients who underwent resection of primary rectal cancer in 2011 (n = 2094) and 2016 (n = 2855) from two nationwide cohorts with a 4-year follow up were included...
March 20, 2024: European Journal of Cancer
#15
EDITORIAL
Stefan Holdenrieder, Huub H van Rossum, Michel van den Heuvel
Blood-based diagnostics for lung cancer support the diagnosis, estimation of prognosis, prediction, and monitoring of therapy response in lung cancer patients. The clinical utility of serum tumor markers has considerably increased due to developments in serum protein tumor markers analytics and clinical biomarker studies, the exploration of preanalytical and influencing conditions, the interpretation of biomarker combinations and individual biomarker kinetics, as well as the implementation of biostatistical models...
2024: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
#16
REVIEW
Yan Xue, Zezhuo Su, Xinyi Lin, Mun Kay Ho, Ken H O Yu
Resolving lineage relationships between cells in an organism provides key insights into the fate of individual cells and drives a fundamental understanding of the process of development and disease. A recent rapid increase in experimental and computational advances for detecting naturally occurring somatic nuclear and mitochondrial mutation at single-cell resolution has expanded lineage tracing from model organisms to humans. This review discusses the advantages and challenges of experimental and computational techniques for cell lineage tracing using somatic mutation as endogenous DNA barcodes to decipher the relationships between cells during development and tumour evolution...
February 2024: Biophysical Reviews
#17
JOURNAL ARTICLE
José María Hernández-Pérez, Carolina Ramos-Izquierdo, Juan Marco Figueira-Gonçalves, Francisco Martínez-Bugallo, Yolanda Ramallo-Fariña, Lorenzo Pérez-Negrín
Different studies have shown that carrying an alpha-1 antitrypsin (AAT) deficiency allele is an independent risk factor for developing lung cancer (LC). However, to date, little is known regarding whether carrying a deficiency allele may be a prognostic factor in the evolution of LC. A prospective observational study was carried out which consecutively included patients diagnosed with LC in University Hospital "Nuestra Señora de Candelaria" between December 2017 and August 2020. A blood sample was taken from each of the patients in order to determine both AAT serum concentration and genotype...
February 29, 2024: Translational Cancer Research
#18
JOURNAL ARTICLE
Julie George, Lukas Maas, Nima Abedpour, Maria Cartolano, Laura Kaiser, Rieke N Fischer, Andreas H Scheel, Jan-Philipp Weber, Martin Hellmich, Graziella Bosco, Caroline Volz, Christian Mueller, Ilona Dahmen, Felix John, Cleidson Padua Alves, Lisa Werr, Jens Peter Panse, Martin Kirschner, Walburga Engel-Riedel, Jessica Jürgens, Erich Stoelben, Michael Brockmann, Stefan Grau, Martin Sebastian, Jan A Stratmann, Jens Kern, Horst-Dieter Hummel, Balazs Hegedüs, Martin Schuler, Till Plönes, Clemens Aigner, Thomas Elter, Karin Toepelt, Yon-Dschun Ko, Sylke Kurz, Christian Grohé, Monika Serke, Katja Höpker, Lars Hagmeyer, Fabian Doerr, Khosro Hekmath, Judith Strapatsas, Karl-Otto Kambartel, Geothy Chakupurakal, Annette Busch, Franz-Georg Bauernfeind, Frank Griesinger, Anne Luers, Wiebke Dirks, Rainer Wiewrodt, Andrea Luecke, Ernst Rodermann, Andreas Diel, Volker Hagen, Kai Severin, Roland T Ullrich, Hans Christian Reinhardt, Alexander Quaas, Magdalena Bogus, Cornelius Courts, Peter Nürnberg, Kerstin Becker, Viktor Achter, Reinhard Büttner, Jürgen Wolf, Martin Peifer, Roman K Thomas
The evolutionary processes that underlie the marked sensitivity of small cell lung cancer (SCLC) to chemotherapy and rapid relapse are unknown1-3 . Here we determined tumour phylogenies at diagnosis and throughout chemotherapy and immunotherapy by multiregion sequencing of 160 tumours from 65 patients. Treatment-naive SCLC exhibited clonal homogeneity at distinct tumour sites, whereas first-line platinum-based chemotherapy led to a burst in genomic intratumour heterogeneity and spatial clonal diversity...
March 13, 2024: Nature
#19
JOURNAL ARTICLE
Anne-Lise Gérard, Rachel S Owen, Antoine M Dujon, Benjamin Roche, Rodrigo Hamede, Frédéric Thomas, Beata Ujvari, Hannah V Siddle
Since the emergence of a transmissible cancer, devil facial tumour disease (DFT1), in the 1980s, wild Tasmanian devil populations have been in decline. In 2016, a second, independently evolved transmissible cancer (DFT2) was discovered raising concerns for survival of the host species. Here, we applied experimental and modelling frameworks to examine competition dynamics between the two transmissible cancers in vitro. Using representative cell lines for DFT1 and DFT2, we have found that in monoculture, DFT2 grows twice as fast as DFT1 but reaches lower maximum cell densities...
March 2024: Evolutionary Applications
#20
REVIEW
Pascal Meier, Arnaud J Legrand, Dieter Adam, John Silke
Most metastatic cancers remain incurable due to the emergence of apoptosis-resistant clones, fuelled by intratumour heterogeneity and tumour evolution. To improve treatment, therapies should not only kill cancer cells but also activate the immune system against the tumour to eliminate any residual cancer cells that survive treatment. While current cancer therapies rely heavily on apoptosis - a largely immunologically silent form of cell death - there is growing interest in harnessing immunogenic forms of cell death such as necroptosis...
March 7, 2024: Nature Reviews. Cancer
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