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Hesperidin AND TGF beta

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https://www.readbyqxmd.com/read/26697692/effect-of-hesperidin-on-tgf-beta1-smad-signaling-pathway-in-hsc
#1
Fu-rong Wu, Ling Jiang, Xiao-li He, Peng-li Zhu, Jun Li
Liver fibrosis is a common pathological process for chronic liver injury caused by multiple etiological factors and an inevitable phase leading to liver cirrhosis. According to the previous studies, hesperidin (HDN) shows a very good protective effect on CCl4-induced chemical hepatic fibrosis in rats. In this experiment, based on the findings of the previous studies, a platelet-derived growth factor (PDGF)-induced HSC-T6 model was established to observe the inhibitory effect of HDN on HSC-T6 proliferation. The ELISA method was adopted to detect the content of collagen I in HSC-T6 supernatant...
July 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/25510196/hesperidin-ameliorates-behavioral-impairments-and-neuropathology-of-transgenic-app-ps1-mice
#2
Chaoyun Li, Caroline Zug, Hongchun Qu, Hermann Schluesener, Zhiyuan Zhang
In addition to cognitive impairments, deficits in non-cognitive behaviors are also common neurological sequelae in Alzheimer's disease and its animal models. Hesperidin, a flavanone glycoside found abundantly in citrus fruits, was orally given (100 mg/kg body weight) to 5-month-old transgenic APP/PS1 mice, a mouse model of cerebral amyloidosis for Alzheimer's disease. After a relatively short-term treatment of 10 days, hesperidin significantly restored deficits in non-cognitive nesting ability and social interaction...
March 15, 2015: Behavioural Brain Research
https://www.readbyqxmd.com/read/25226844/hesperidin-prevents-liver-fibrosis-in-rats-by-decreasing-the-expression-of-nuclear-factor-%C3%AE%C2%BAb-transforming-growth-factor-%C3%AE-and-connective-tissue-growth-factor
#3
J Eliuth Pérez-Vargas, Natanael Zarco, Mineko Shibayama, José Segovia, Víctor Tsutsumi, Pablo Muriel
BACKGROUND/AIMS: To evaluate the antioxidant, immunomodulatory, antinecrotic and antifibrotic effects of hesperidin on CCl4-induced cirrhosis. METHODS: Liver damage was produced by giving CCl4 injections (0.4 g/kg, i.p., 3 times per week for 8 weeks) to rats. Hesperidin (200 mg/kg) was administered using gavage. The expression of nuclear factor-κB (NF-κB), transforming growth factor-β (TGF-β), connective tissue growth factor (CTGF), interleukin (IL)-10 and IL-1β was assessed using Western blotting...
2014: Pharmacology
https://www.readbyqxmd.com/read/23719775/hesperetin-protects-against-cardiac-remodelling-induced-by-pressure-overload-in-mice
#4
Wei Deng, Duan Jiang, Yi Fang, Heng Zhou, Zhihong Cheng, Yafen Lin, Rui Zhang, Jieyu Zhang, Peng Pu, Yuan Liu, Zhouyan Bian, Qizhu Tang
Cardiac remodelling is a major determinant of heart failure (HF) and is characterised by cardiac hypertrophy, fibrosis, oxidative stress and myocytes apoptosis. Hesperetin, which belongs to the flavonoid subgroup of citrus flavonoids, is the main flavonoid in oranges and possesses multiple pharmacological properties. However, its role in cardiac remodelling remains unknown. We determined the effect of hesperetin on cardiac hypertrophy, fibrosis and heart function using an aortic banding (AB) mouse. Male, 8-10-week-old, wild-type C57 mice with or without oral hesperetin administration were subjected to AB or a sham operation...
October 2013: Journal of Molecular Histology
https://www.readbyqxmd.com/read/23153811/hesperetin-an-inhibitor-of-the-transforming-growth-factor-%C3%AE-tgf-%C3%AE-signaling-pathway
#5
Yong Yang, Joy Wolfram, Haifa Shen, Xiaohong Fang, Mauro Ferrari
We have identified a previously unknown function of the natural compound, hesperetin. Here, we demonstrate that this small molecular agent is able to inhibit the transforming growth factor-β (TGF-β) signaling pathway. Single-molecule force measurements and single-molecule fluorescence imaging show that hesperetin interferes with ligand-receptor interactions. Furthermore, by Western blot analysis, it was confirmed that hesperetin also inhibits the phosphorylation of Smad3, a down-stream target of the TGF-β pathway...
December 2012: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/12939048/propolis-and-some-of-its-constituents-down-regulate-dna-synthesis-and-inflammatory-cytokine-production-but-induce-tgf-beta1-production-of-human-immune-cells
#6
Siegfried Ansorge, Dirk Reinhold, Uwe Lendeckel
Propolis, the resinous product collected by honey bees from plants, is used as folk medicine since ancient time. Recently, immunoregulatory and anti-inflammatory properties of propolis have been published. The detailed mechanisms of actions of propolis and its components on immune cells, however, are still unknown. Therefore, we studied the effects of different propolis extracts, of the flavonoids hesperidin and quercetin as well as of caffeic acid phenethyl ester (CAPE) on basic human immune cell functions...
July 2003: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
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