keyword
https://read.qxmd.com/read/38508449/double-balloon-catheter-mediated-transarterial-chemotherapy-delivery-in-a-swine-model-a-mechanism-recruiting-the-vasa-vasorum-for-localized-therapies
#1
JOURNAL ARTICLE
Khashayar Farsad, Paula M Novelli, Christopher Laing, Ripal T Gandhi, Jacob Cynamon, Claudia S López, Erin S Stempinski, Robert Strasser, Ramtin Agah
Treatment of hypovascular tumors, such as pancreatic adenocarcinoma, is challenging due to inefficient drug delivery. This report examines the potential mechanism of localized drug delivery via trans-arterial micro perfusion (TAMP) using a proprietary adjustable double-balloon occlusion catheter in a porcine model. Adult Yorkshire swine (N=21) were used in IACUC-approved protocols. The RC-120 catheter was positioned into visceral, femoral, and pulmonary arteries with infusion of methylene blue dye, gemcitabine, or gold nanoparticles...
March 18, 2024: Journal of Vascular and Interventional Radiology: JVIR
https://read.qxmd.com/read/38084422/trans-catheter-closure-of-an-unusual-type-of-abernethy-malformation-in-a-child-presenting-with-severe-pulmonary-hypertension
#2
JOURNAL ARTICLE
Santosh Wadile, Ashishkumar Banpurkar, Snehal Kulkarni
Abernethy malformation is a congenital extra-hepatic porto-systemic shunt. This malformation is characterized by an abnormal connection between the portal vein or its branches and one of the systemic veins. Though rare, this anomaly can lead to pulmonary hypertension. Drainage of Abernethy malformation into coronary sinus is extremely rare. We describe a child with Abernethy malformation with unusual drainage into coronary sinus. The abnormal channel was successfully closed by trans-catheter technique with normalisation of pulmonary arterial pressures...
December 12, 2023: Cardiology in the Young
https://read.qxmd.com/read/38082998/hemodynamic-effect-of-a-fontan-assist-device-on-a-numerical-fontan-circulatory-model-under-various-medication-scenarios
#3
JOURNAL ARTICLE
Phong Tran, Preston Peak, Shweta Karnik, David Nguyen, Katharine Fraser, Christopher Broda, Yaxin Wang
Patients with single-ventricle heart disease and failing Fontan circulation represent the largest and most rapidly growing subgroup of adults with congenital heart disease referred for transplant assessment. Few clinical therapies are available for improving Fontan hemodynamics. Mechanical circulatory support devices have been used successfully in the clinical setting to assist the single ventricle, but no device is currently available to support the subpulmonary circulation. A subpulmonary pump could be used to support patients with failing Fontan circulation by mitigating chronic venous hypertension and restoring normal physiology...
July 2023: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/38037796/intraoperative-transit-time-flow-measurement-of-caval-veins-before-and-after-bidirectional-cavopulmonary-anastomosis
#4
JOURNAL ARTICLE
Sara C Arrigoni, Joost M A A van der Maaten, Marc T R Roofthooft, Roland F Hoffmann, Rolf M F Berger, Tjark Ebels
BACKGROUND: Haemodynamic changes in caval venous flow distribution occurring during bidirectional cavopulmonary anastomosis operation are still largely unknown. METHODS: Transit time flow measurements were performed in 15 cavopulmonary anastomosis operations. Superior and inferior caval vein flows were measured before and after the cavopulmonary anastomosis. Ratio of superior caval vein to overall caval veins flow was calculated. RESULTS: Mean superior caval vein flow ratio before cavopulmonary anastomosis was higher than previously reported for healthy children...
December 1, 2023: Cardiology in the Young
https://read.qxmd.com/read/38018039/clinical-utility-of-chest-sonography-in-copd-patients-with-a-focus-on-diaphragmatic-measurements
#5
JOURNAL ARTICLE
Hend M Esmaeel, Kamal A Atta, Safiya Khalaf, Doaa Gadallah
BACKGROUND: There are many methods of evaluating diaphragmatic function, such as trans-diaphragmatic pressure measurements, which are considered the key rule of diagnosis, we studied the clinical usefulness of chest ultrasonography in evaluating stable COPD patients and those in exacerbation, we focus on diaphragmatic measurements and their correlation to spirometry and other clinical parameters. METHODS: In a prospective case control study, we enrolled 100 COPD patients divided into 40 stable COPD patients and 60 patients with exacerbation...
November 29, 2023: Tuberculosis and Respiratory Diseases
https://read.qxmd.com/read/37998528/the-predictors-and-outcomes-of-functional-mitral-stenosis-following-surgical-mitral-valve-repair-a-retrospective-analysis
#6
JOURNAL ARTICLE
Yu-Ning Hu, Wen-Huang Lee, Meng-Ta Tsai, Yi-Chen Wang, Chao-Jung Shih, Yu-Ching Huang, Jun-Neng Roan
To optimize mitral valve repair outcomes, it is crucial to comprehend the predictors of functional mitral valve stenosis (FMS), to enhance preoperative assessments, and to adapt intraoperative treatment strategies. This study aimed to identify FMS risk factors, contributing valuable insights for refining surgical techniques. Among 228 selected patients, 215 underwent postoperative echocardiography follow-ups, and 36 met the FMS criteria based on a mean trans-mitral pressure gradient of >5 mmHg. Patients with FMS exhibited higher pulmonary systolic arterial pressure and increased late mortality during the follow-up...
November 19, 2023: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/37968674/short-term-study-of-atrial-shunt-and-improvement-of-functional-mitral-regurgitation
#7
JOURNAL ARTICLE
Xiaoke Shang, Mei Liu, Yucheng Zhong, Xueli Wang, Song Chen, Xiaojuan Fu, Ming Sun, Geng Li, Mingxing Xie, Guangyuan Song, Da Zhu, Changdong Zhang, Nianguo Dong
BACKGROUND: This study used an atrial septal shunt to compare the treatment progress and prognosis for patients with heart failure (HF) who have different ejection fractions. METHODS: Twenty HF patients with pulmonary hypertension, who required atrial septal shunt therapy, were included in this study. The patients underwent surgery between December 2012 and December 2020. They were divided into two groups based on their ejection fraction: a group with reduced ejection fraction (HFrEF) and a group with preserved ejection fraction(HFpEF) + mid-range ejection fraction (HfmrEF)...
November 15, 2023: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/37767953/evaluation-of-right-ventricular-diastolic-function-systolic-function-and-circulating-galectin-3-concentrations-in-dogs-with-pulmonary-stenosis
#8
JOURNAL ARTICLE
Randolph L Winter, Kara L Maneval, Claudio Serrano Ferrel, William A Clark, Emily J Herrold, Jaylyn D Rhinehart
BACKGROUND: Cardiovascular diseases with increased right ventricular (RV) afterload induce RV diastolic and systolic dysfunction, and myocardial fibrosis in humans. Studies in dogs with pulmonary stenosis (PS) evaluating RV diastolic function and markers of myocardial fibrosis are lacking. HYPOTHESIS/OBJECTIVES: Dogs with PS have echocardiographic evidence of RV diastolic and systolic dysfunction and increased serum concentrations of galectin-3 (Gal-3), a surrogate biomarker for myocardial fibrosis...
September 28, 2023: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/37583330/-preliminary-experience-of-transcatheter-pulmonary-valve-replacement-using-domestic-balloon-expandable-valve
#9
JOURNAL ARTICLE
Z G Zhao, R T Li, X Wei, Y Peng, J F Wei, S He, Q Li, X Li, Y J Li, X Li, X Zhou, M X Zheng, G Chen, Q An, M Chen, Y Feng
Objectives: To evaluate the feasibility and preliminary clinical results of transcatheter pulmonary valve replacement (TPVR) with the domestically-produced balloon-expandable Prizvalve system. Methods: This is a prospective single-center observational study. Patients with postoperative right ventricular outflow tract (RVOT) dysfunction, who were admitted to West China Hospital of Sichuan University from September 2021 to March 2023 and deemed anatomically suitable for TPVR with balloon-expandable valve, were included...
August 24, 2023: Zhonghua Xin Xue Guan Bing za Zhi
https://read.qxmd.com/read/37568502/early-hospital-discharge-using-remote-monitoring-for-patients-hospitalized-for-covid-19-regardless-of-need-for-home-oxygen-therapy-a-descriptive-study
#10
JOURNAL ARTICLE
Samy Talha, Sid Lamrous, Loic Kassegne, Nicolas Lefebvre, Abrar-Ahmad Zulfiqar, Pierre Tran Ba Loc, Marie Geny, Nicolas Meyer, Mohamed Hajjam, Emmanuel Andrès, Bernard Geny
AIM: Since beds are unavailable, we prospectively investigated whether early hospital discharge will be safe and useful in patients hospitalized for COVID-19, regardless of their need for home oxygen therapy. POPULATION AND METHODS: Extending the initial inclusion criteria, 62 patients were included and 51 benefited from home telemonitoring, mainly assessing clinical parameters (blood pressure, heart rate, respiratory rate, dyspnea, temperature) and peripheral saturation (SpO2 ) at follow-up...
August 3, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37555056/temporary-venovenous-extracorporeal-membrane-oxygenation-after-cardiopulmonary-bypass-in-minimally-invasive-cardiac-surgery-via-right-minithoracotomy
#11
JOURNAL ARTICLE
Hiroshi Nakanaga, Takeshi Kinoshita, Hiromi Fujii, Kohei Nagashima, Minoru Tabata
OBJECTIVES: In minimally invasive cardiac surgery, it can be difficult at times to maintain adequate oxygenation with single-lung ventilation after weaning from cardiopulmonary bypass (CPB), and intermittent double-lung ventilation is required during hemostasis. Venovenous extracorporeal membrane oxygenation (VV-ECMO) after weaning from CPB eliminates the necessity of overinflation of the left lung and intermittent double-lung ventilation and enables secure and fast hemostasis. We investigated the effectiveness and safety of temporary VV-ECMO in MICS...
August 2023: JTCVS techniques
https://read.qxmd.com/read/37532895/an-experimental-cold-gas-cannon-for-the-study-of-porcine-lung-contusion-and-behind-armor-blunt-trauma
#12
JOURNAL ARTICLE
Tomas Karlsson, Lars-Gunnar Olsson, Jenny Gustavsson, Ulf P Arborelius, Mårten Risling, Mattias Günther
Behind armor blunt trauma (BABT) is a non-penetrating injury caused by the rapid deformation of body armor, by a projectile, which may in extreme circumstances cause death. The understanding of the mechanisms is still low, in relation to what is needed for safety threshold levels. Few models of graded kinetic energy transfer to the body exist. We established an experimental model for graded BABT. The cold gas cannon was air-driven, consisted of a pressure vessel, a barrel, and a pressure actuator. It required short training to operate and was constructed by standard components...
August 2, 2023: Annals of Biomedical Engineering
https://read.qxmd.com/read/37361478/association-between-right-heart-catheterization-hemodynamics-and-glycosylated-hemoglobin-levels-in-adults-with-heart-failure-with-reduced-ejection-fraction
#13
JOURNAL ARTICLE
Gaspar Del Rio-Pertuz, Cristina Morataya, Kanak Parmar, Zeyad Elharabi, Daniel Davis, Mostafa Abohelwa, Ozman Ochoa, Alison Tran, Kenneth Nugent, David Paniagua, Erwin Argueta-Sosa
UNLABELLED: This study hypothesized that elevated glycosylated hemoglobin (HbA1c) levels are associated with abnormal right heart catheterization (RHC) hemodynamic parameters in patients with heart failure with reduced ejection fraction (HFrEF) and no prior diagnosis of diabetes. METHODS: Retrospective cohort study of adult patients with HFrEF and no prior diagnosis of diabetes who underwent RHC and had HbA1c levels measured 30 days before or after the RHC. This study excluded patients who had received blood transfusions within 90 days prior to HbA1c measurement and patients with known diabetes...
September 2023: Cardiovascular endocrinology & metabolism
https://read.qxmd.com/read/37330047/effects-of-lifestyle-and-associated-diseases-on-serum-cc16-suggest-complex-interactions-among-metabolism-heart-and-lungs
#14
JOURNAL ARTICLE
Nathalie Rohmann, Paula Stürmer, Corinna Geisler, Kristina Schlicht, Carina Knappe, Katharina Hartmann, Kathrin Türk, Tim Hollstein, Alexia Beckmann, Anna K Seoudy, Ulla Becker, Perdita Wietzke-Braun, Ute Settgast, Florian Tran, Philip Rosenstiel, Jan H Beckmann, Witigo von Schönfels, Stephan Seifert, Jan Heyckendorf, Andre Franke, Stefan Schreiber, Dominik M Schulte, Matthias Laudes
INTRODUCTION: Clara cell 16-kDa protein (CC16) is an anti-inflammatory, immunomodulatory secreted pulmonary protein with reduced serum concentrations in obesity according to recent data. OBJECTIVE: Studies focused solely on bodyweight, which does not properly reflect obesity-associated implications of the metabolic and reno-cardio-vascular system. The purpose of this study was therefore to examine CC16 in a broad physiological context considering cardio-metabolic comorbidities of primary pulmonary diseases...
June 16, 2023: Journal of Advanced Research
https://read.qxmd.com/read/37284356/improvement-of-breast-cancer-associated-pulmonary-tumor-thrombotic-microangiopathy-with-carboplatin-and-gemcitabine
#15
Helen Tran, Nader Kamangar
We present the case of a 50-year-old woman with stage IV invasive ER+/PR-/HER2-ductal breast carcinoma who was admitted to the intensive care unit (ICU) with obstructive shock and hypoxic respiratory failure due to pulmonary tumor thrombotic microangiopathy (PTTM), which significantly improved with chemotherapy. Upon presentation, her heart rate was 145 beats/min, her blood pressure was 86/47 mmHg, her respiratory rate was 25 breaths/min, and her oxygen saturation was 80% in room air. She underwent a broad non-diagnostic infectious evaluation, received fluid resuscitation, and was placed on broad-spectrum antibiotics...
May 2023: Curēus
https://read.qxmd.com/read/37115698/pressure-overload-induces-isg15-to-facilitate-adverse-ventricular-remodeling-and-promote-heart-failure
#16
JOURNAL ARTICLE
Veera Ganesh Yerra, Sri Nagarjun Batchu, Harmandeep Kaur, M D Golam Kabir, Youan Liu, Suzanne L Advani, Duc Tin Tran, Shadi Sadeghian, Phelopater Sedrak, Filio Billia, Uros Kuzmanov, Anthony O Gramolini, Deema O Qasrawi, Evgeniy V Petrotchenko, Christoph H Borchers, Kim A Connelly, Andrew Advani
Inflammation promotes adverse ventricular remodeling, a common antecedent of heart failure. Here, we set out to determine how inflammatory cells affect cardiomyocytes in the remodeling heart. Pathogenic cardiac macrophages induced an IFN response in cardiomyocytes, characterized by upregulation of the ubiquitin-like protein IFN-stimulated gene 15 (ISG15), which posttranslationally modifies its targets through a process termed ISGylation. Cardiac ISG15 is controlled by type I IFN signaling, and ISG15 or ISGylation is upregulated in mice with transverse aortic constriction or infused with angiotensin II; rats with uninephrectomy and DOCA-salt, or pulmonary artery banding; cardiomyocytes exposed to IFNs or CD4+ T cell-conditioned medium; and ventricular tissue of humans with nonischemic cardiomyopathy...
May 1, 2023: Journal of Clinical Investigation
https://read.qxmd.com/read/37109401/hands-off-trans-femoral-venous-intra-abdominal-pressure-estimates-in-children-results-of-a-sobering-single-center-study
#17
JOURNAL ARTICLE
Miriam Gutting, Lara Klischke, Torsten Kaussen
BACKGROUND: For a long time, trans-femoral venous pressure (FVP) measurement was considered a simple alternative for estimating intra-abdominal pressure (IAP). Since intravesical [IVP] and intragastric [IGP] pressure measurements are sometimes contraindicated for anatomical and pathophysiological reasons, FVP raised hopes, especially among pediatricians. Pediatric FVP validation studies have never been published; recent results from adult studies cast doubt on their interchangeability...
March 24, 2023: Life
https://read.qxmd.com/read/37099262/tricuspid-regurgitation-right-ventricular-volume-versus-pressure-load
#18
REVIEW
Robert Naeije, Khodr Tello, Michele D'Alto
PURPOSE OF THE REVIEW: Tricuspid regurgitation is associated with increased mortality in proportion to right ventricular adaptation to increased volume loading and pulmonary artery pressure. We here review recent progress in the understanding of right ventricular adaptation to pre- and after-loading conditions for improved recommendations of tricuspid valve repair. RECENT FINDINGS: Trans-catheter tricuspid valve repair has made the correction of tricuspid regurgitation more easily available, triggering a need of tighter indications...
June 2023: Current Heart Failure Reports
https://read.qxmd.com/read/37071180/a-biomimetic-approach-utilizing-pulsatile-perfusion-generates-contractile-vascular-grafts
#19
JOURNAL ARTICLE
Cole Knox, Keren Garcia, Jade Tran, Sean Wilson, Arlin Blood, Mary Kearns-Jonker, Timothy Martens
BACKGROUND: Surgical implantation of decellularized cadaveric arteries is routinely used to treat right-sided congenital cardiac lesions. These acellular conduits lack the capacity for somatic growth and are prone to stenosis and calcification necessitating multiple operations throughout childhood. Islet-1+ cardiovascular progenitor cells (CPCs) have demonstrated the capacity for differentiation into all cell types of the heart and outflow tracts. We hypothesize that CPC-seeding of decellularized pulmonary arteries and bioreactor culture under physiologic flow conditions will drive vascular differentiation of CPCs and result in a conduit more suitable for implantation and long-term growth...
April 18, 2023: Tissue Engineering. Part A
https://read.qxmd.com/read/37069661/pulmonary-tumor-thrombotic-microangiopathy-during-good-response-to-immuno-chemotherapy-for-advanced-non-small-cell-lung-cancer-a-case-report
#20
JOURNAL ARTICLE
Yoshikazu Utsu, Makio Kawakami, Hironori Arai, Haruka Hisamatsu, Yudai Yano, Jiro Terada
BACKGROUND: Pulmonary tumor thrombotic microangiopathy is a rapidly progressive and fatal disease in which tumor cells embolize to the pulmonary microvasculature. This condition is characterized by severe dyspnea and right heart failure. Although pulmonary tumor thrombotic microangiopathy typically occurs in patients with untreated and/or advanced cancer, its occurrence in patients who are responding well to medical therapy is poorly documented. CASE PRESENTATION: A 68-year-old Japanese woman who had received four cycles of immuno-chemotherapy (pembrolizumab, carboplatin, and pemetrexed) followed by three cycles of maintenance therapy (pembrolizumab and pemetrexed) for advanced non-small cell lung cancer and had achieved a partial response with a stable clinical course was admitted to the emergency ward because of worsening breathlessness and general fatigue for 1 week...
April 17, 2023: BMC Pulmonary Medicine
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