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https://www.readbyqxmd.com/read/28269728/modeling-and-design-of-antennas-for-implantable-telemetry-applications
#1
Arun Venkatasubramanian, Brandon Gifford
Incorporating an RF communications link in an implanted medical device can increase its range of applicability and improve quality of life for the patient. Developments in support electronics decrease design risk, but the implanted antenna remains a critical component of a communications link that operates at very low received power. Transmitted power is limited both by regulatory restrictions and, for most implanted devices, by power source capacity. Dielectric losses and wave trapping in the body result in transmission losses much greater than seen in free space communications...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28237595/effect-of-short-term-feed-restriction-on-temporal-changes-in-milk-components-and-mammary-lipogenic-gene-expression-in-mid-lactation-holstein-dairy-cows
#2
A M Abdelatty, M E Iwaniuk, M Garcia, K M Moyes, B B Teter, P Delmonte, A K G Kadegowda, M A Tony, F F Mohamad, R A Erdman
Investigations of the temporal changes in mammary gene expression that occur during sudden diet change have been limited by the use of mammary tissue as the source of RNA because of the invasive nature of mammary biopsy procedures. However, the cytosolic crescent, present in 1% of the largest milk fat globules, contains mammary epithelial cell RNA that has become trapped between the inner and outer milk fat globule membranes during final formation and secretion of milk fat into the lumen of the mammary alveoli...
February 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28236130/entrapment-of-the-posterior-femoral-cutaneous-nerve-and-its-inferior-cluneal-branches-anatomical-basis-of-surgery-for-inferior-cluneal-neuralgia
#3
Stéphane Ploteau, Céline Salaud, Antoine Hamel, Roger Robert
PURPOSE: The apparent failure of pudendal nerve surgery in some patients has led us to suggest the possibility of entrapment of other adjacent nerve structures, leading to the concept of inferior cluneal neuralgia. Via its numerous collateral branches, the posterior femoral cutaneous nerve innervates a very extensive territory including the posterior surface of the thigh, the infragluteal fold, the skin over the ischial tuberosity, but also the lateral anal region, scrotum or labium majus via its perineal branch...
February 24, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28227992/modeling-and-design-of-antennas-for-implantable-telemetry-applications
#4
Arun Venkatasubramanian, Brandon Gifford, Arun Venkatasubramanian, Brandon Gifford, Brandon Gifford, Arun Venkatasubramanian
Incorporating an RF communications link in an implanted medical device can increase its range of applicability and improve quality of life for the patient. Developments in support electronics decrease design risk, but the implanted antenna remains a critical component of a communications link that operates at very low received power. Transmitted power is limited both by regulatory restrictions and, for most implanted devices, by power source capacity. Dielectric losses and wave trapping in the body result in transmission losses much greater than seen in free space communications...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28195977/fat-grip-resistance-training-improves-driving-performance-in-division-i-male-golfers
#5
Patrick M Cummings, Hunter S Waldman, Ben M Krings, JohnEric W Smith, Matthew J McAllister
Fat Grip (FG) training is implemented into strength and conditioning programs with the overall goal of increasing grip strength. Previous research assessing the effect of training with increased grip diameters compared to standard Olympic bar diameters has mainly been in acute settings. Therefore, the purpose of this study was to examine to effects FG training compared to normal diameter grip (CON) training during an eight week periodized resistance training (RT) program in Division I male golfers. Subjects (n = 10) were randomly assigned into two groups: the FG group (n = 5, scoring average: 75...
February 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28177896/monocyte-chemotactic-protein-1-deficiency-attenuates-and-high-fat-diet-exacerbates-bone-loss-in-mice-with-lewis-lung-carcinoma
#6
Lin Yan, Forrest H Nielsen, Sneha Sundaram, Jay Cao
Bone loss occurs in obesity and cancer-associated complications including wasting. This study determined whether a high-fat diet and a deficiency in monocyte chemotactic protein-1 (MCP-1) altered bone structural defects in male C57BL/6 mice with Lewis lung carcinoma (LLC) metastases in lungs. Compared to non-tumor-bearing mice, LLC reduced bone volume fraction, connectivity density, trabecular number, trabecular thickness and bone mineral density and increased trabecular separation in femurs. Similar changes occurred in vertebrae...
February 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28173868/docosahexaenoic-acid-increases-accumulation-of-adipocyte-triacylglycerol-through-up-regulation-of-lipogenic-gene-expression-in-pigs
#7
Chao-Wei Huang, Yu-Jen Chen, Jui-Ting Yang, Ching-Yi Chen, Kolapo M Ajuwon, Shuen-Ei Chen, Nan-Wei Su, Yu-Shan Chen, Harry J Mersmann, Shih-Torng Ding
BACKGROUND: Changing dietary fatty acid composition in modern diet influences the prevalence of obesity. Increasing evidences suggest favorable effects of n-3 PUFA for protecting against obesity and the metabolic syndrome. However, the regulation of n-3 PUFA in adipose is still unclear. Thus, this study addressed metabolism of different dietary fats in the adipose tissue of porcine model. METHODS: Eight-week-old cross-bred pigs were randomly assigned to three groups and fed a 2% fat diet for 30 days from either soybean oil (SBO), docosahexaenoic acid (DHA) or beef tallow...
February 7, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28078077/a-novel-method-for-the-quantification-of-fatty-infiltration-in-skeletal-muscle
#8
Nicole K Biltz, Gretchen A Meyer
BACKGROUND: Fatty infiltration of the skeletal muscle is a common but poorly understood feature of many myopathies. It is best described in human muscle, where non-invasive imaging techniques and representative histology have been optimized to view and quantify infiltrating fat. However, human studies are limited in their ability to identify cellular and molecular mechanisms regulating fatty infiltration, a likely prerequisite to developing targeted interventions. As mechanistic investigations move to small animals, studies may benefit from new or adapted imaging tools optimized for high resolution and whole muscle quantification...
2017: Skeletal Muscle
https://www.readbyqxmd.com/read/28073372/a-novel-method-for-the-quantification-of-fatty-infiltration-in-skeletal-muscle
#9
Nicole K Biltz, Gretchen A Meyer
BACKGROUND: Fatty infiltration of the skeletal muscle is a common but poorly understood feature of many myopathies. It is best described in human muscle, where non-invasive imaging techniques and representative histology have been optimized to view and quantify infiltrating fat. However, human studies are limited in their ability to identify cellular and molecular mechanisms regulating fatty infiltration, a likely prerequisite to developing targeted interventions. As mechanistic investigations move to small animals, studies may benefit from new or adapted imaging tools optimized for high resolution and whole muscle quantification...
January 10, 2017: Skeletal Muscle
https://www.readbyqxmd.com/read/28071704/high-fat-diet-induced-changes-of-mouse-hepatic-transcription-and-enhancer-activity-can-be-reversed-by-subsequent-weight-loss
#10
Majken Siersbæk, Lyuba Varticovski, Shutong Yang, Songjoon Baek, Ronni Nielsen, Susanne Mandrup, Gordon L Hager, Jay H Chung, Lars Grøntved
Epigenetic factors have been suggested to play an important role in metabolic memory by trapping and maintaining initial metabolic changes within the transcriptional regulatory machinery. In this study we fed mice a high fat diet (HFD) for seven weeks followed by additional five weeks of chow, to identify HFD-mediated changes to the hepatic transcriptional program that may persist after weight loss. Mice fed a HFD displayed increased fasting insulin levels, hepatosteatosis and major changes in hepatic gene transcription associated with modulation of H3K27Ac at enhancers, but no significant changes in chromatin accessibility, indicating that HFD-regulated gene transcription is primarily controlled by modulating the activity of pre-established enhancers...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27992512/68ga-trap-rgd-3-hybrid-imaging-for-the-in-vivo-monitoring-of-%C3%AE-v%C3%A3-3-integrin-expression-as-biomarker-of-anti-angiogenic-therapy-effects-in-experimental-breast-cancer
#11
Philipp M Kazmierczak, Andrei Todica, Franz-Josef Gildehaus, Heidrun Hirner-Eppeneder, Matthias Brendel, Ralf S Eschbach, Magdalena Hellmann, Konstantin Nikolaou, Maximilian F Reiser, Hans-Jürgen Wester, Saskia Kropf, Axel Rominger, Clemens C Cyran
OBJECTIVES: To investigate 68Ga-TRAP-(RGD)3 hybrid imaging for the in vivo monitoring of αvß3-integrin expression as biomarker of anti-angiogenic therapy effects in experimental breast cancer. MATERIALS AND METHODS: Human breast cancer (MDA-MB-231) xenografts were implanted orthotopically into the mammary fat pads of n = 25 SCID mice. Transmission/emission scans (53 min to 90 min after i.v. injection of 20 MBq 68Ga-TRAP-(RGD)3) were performed on a dedicated small animal PET before (day 0, baseline) and after (day 7, follow-up) a 1-week therapy with the VEGF antibody bevacizumab or placebo (imaging cohort n = 13; therapy n = 7, control n = 6)...
2016: PloS One
https://www.readbyqxmd.com/read/27981392/histological-evidence-that-metformin-reverses-the-adverse-effects-of-diabetes-on-orthodontic-tooth-movement-in-rats
#12
Jing Sun, Juan Du, Wei Feng, Boyao Lu, Hongrui Liu, Jie Guo, Norio Amizuka, Minqi Li
This study evaluated the effects of metformin on orthodontic tooth movement in a rat model of type 2 diabetes mellitus. Rats were fed a high-fat diet for 4 weeks to induce fat accumulation and insulin resistance, and then injected with a low dose of streptozotocin (35 mg/kg) intraperitoneally to induce type 2 diabetes. An orthodontic appliance was placed in normoglycemic, type 2 diabetes, and type 2 diabetes with metformin-administrated rats. After 14 days, type 2 diabetes rats exhibited greater orthodontic tooth movement and had a higher number of tartrate-resistant acid phosphatase-positive osteoclasts, stronger cathepsin K expression, and weaker alkaline phosphatase immunostaining than normoglycemic rats...
April 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/27933990/automated-enrichment-of-sulfanilamide-in-milk-matrices-by-utilization-of-aptamer-linked-magnetic-particles
#13
Christin Fischer, Constanze Kallinich, Sven Klockmann, Jil Schrader, Markus Fischer
The present work demonstrates the first automated enrichment approach for antibiotics in milk using specific DNA aptamers. First, aptamers toward the antibiotic sulfanilamide were selected and characterized regarding their dissociation constants and specificity toward relevant antibiotics via fluorescence assay and LC-MS/MS detection. The performed enrichment was automated using the KingFisherDuo and compared to a manual approach. Verifying the functionality, trapping was realized in different milk matrices: (i) 0...
December 7, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27923100/effects-of-air-pollution-exposure-on-glucose-metabolism-in-los-angeles-minority-children
#14
C M Toledo-Corral, T L Alderete, R Habre, K Berhane, F W Lurmann, M J Weigensberg, M I Goran, F D Gilliland
OBJECTIVES: Growing evidence indicates that ambient (AAP: NO2 , PM2.5 and O3 ) and traffic-related air pollutants (TRAP) contribute to metabolic disease risk in adults; however, few studies have examined these relationships in children. METHODS: Metabolic profiling was performed in 429 overweight and obese African-American and Latino youth living in urban Los Angeles, California. This cross-sectional study estimated individual residential air pollution exposure and used linear regression to examine relationships between air pollution and metabolic outcomes...
December 6, 2016: Pediatric Obesity
https://www.readbyqxmd.com/read/27768123/milk-fat-globule-egf-factor-8-suppresses-the-aberrant-immune-response-of-systemic-lupus-erythematosus-derived-neutrophils-and-associated-tissue-damage
#15
Wei Huang, Jiyuan Wu, Huiqin Yang, Yin Xiong, Rui Jiang, Tianpen Cui, Duyun Ye
Abnormal features of the systemic lupus erythematosus (SLE)-derived neutrophils, promoted aberrant immune response, have inspired new studies of the induction of autoimmunity and the development of organ damage in SLE. In this study, we explore the effect of milk fat globule-EGF factor 8 (MFG-E8) on the aberrant nitrification features in pristane-induced lupus. SLE patients and mice with pristane-induced lupus develop autoantibodies associated with MFG-E8 overproduction. However, the deletion of MFG-E8 leads to uncontrolled early pulmonary and peritoneal inflammation and tissue damage in mice with pristane-induced lupus...
February 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27701440/inhibition-of-net-release-fails-to-reduce-adipose-tissue-inflammation-in-mice
#16
Quinte Braster, Carlos Silvestre Roig, Helene Hartwig, Linda Beckers, Myrthe den Toom, Yvonne Döring, Mat J Daemen, Esther Lutgens, Oliver Soehnlein
Obesity-associated diseases such as Type 2 diabetes, liver disease and cardiovascular diseases are profoundly mediated by low-grade chronic inflammation of the adipose tissue. Recently, the importance of neutrophils and neutrophil-derived myeloperoxidase and neutrophil elastase on the induction of insulin resistance has been established. Since neutrophil elastase and myeloperoxidase are critically involved in the release of neutrophil extracellular traps (NETs), we here hypothesized that NETs may be relevant to early adipose tissue inflammation...
2016: PloS One
https://www.readbyqxmd.com/read/27669658/reduced-femoral-bone-mass-in-both-diet-induced-and-genetic-hyperlipidemia-mice
#17
Xiang Chen, Chunyu Wang, Kun Zhang, Ying Xie, Xiao Ji, Hui Huang, Xijie Yu
Growing evidence argues for a relationship between lipid and bone metabolisms with inconsistent conclusions. Sphingosine-1-phosphate (S1P) has been recognized as a suitable candidate for possible link between lipid metabolism and bone metabolism. This study was designed to investigate the effects of hyperlipidemia on bone metabolism using diet-induced and genetic-induced hyperlipidemia animal models and to explore whether S1P is involved. Wild-type mice and low-density lipoprotein receptor gene deficient (LDLR(-/-)) mice at age of 8weeks were placed on either control diet or high-fat diet (HFD) for 12weeks...
September 23, 2016: Bone
https://www.readbyqxmd.com/read/27666759/ligand-trap-of-the-activin-receptor-type-iia-inhibits-osteoclast-stimulation-of-bone-remodeling-in-diabetic-mice-with-chronic-kidney-disease
#18
Toshifumi Sugatani, Olga A Agapova, Yifu Fang, Alycia G Berman, Joseph M Wallace, Hartmut H Malluche, Marie-Claude Faugere, William Smith, Victoria Sung, Keith A Hruska
Dysregulation of skeletal remodeling is a component of renal osteodystrophy. Previously, we showed that activin receptor signaling is differentially affected in various tissues in chronic kidney disease (CKD). We tested whether a ligand trap for the activin receptor type 2A (RAP-011) is an effective treatment of the osteodystrophy of the CKD-mineral bone disorder. With a 70% reduction in the glomerular filtration rate, CKD was induced at 14 weeks of age in the ldlr-/- high fat-fed mouse model of atherosclerotic vascular calcification and diabetes...
January 2017: Kidney International
https://www.readbyqxmd.com/read/27623367/thermophilic-and-hyper-thermophilic-co-digestion-of-waste-activated-sludge-and-fat-oil-and-grease-evaluating-and-modeling-methane-production
#19
Rania Mona Alqaralleh, Kevin Kennedy, Robert Delatolla, Majid Sartaj
Renewable energy and clean environment are two crucial requirements for our modern world. Low cost, energy production and limited environmental impact make anaerobic digestion (AD) a promising technology for stabilizing organic waste and in particular, sewage waste. The anaerobic co-digestion of thickened waste activated sludge (TWAS) and sewage treatment plant trapped fat, oil and grease (FOG) using different FOG-TWAS mixtures (20, 40, 60 and 80% of FOG based on total volatile solids (TVS)) were investigated in this study using both thermophilic (55 ± 1 °C) and two stages hyper-thermophilic/thermophilic (70 ± 1 °C and 55 ± 1 °C) anaerobic co-digestion...
December 1, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27531997/effect-of-high-fat-diet-on-the-formation-of-pulmonary-neutrophil-extracellular-traps-during-influenza-pneumonia-in-balb-c-mice
#20
Anandi Narayana Moorthy, Kong Bing Tan, Shi Wang, Teluguakula Narasaraju, Vincent T Chow
Obesity is an independent risk factor for severe outcome of influenza infection. Higher dietary fat consumption has been linked to greater morbidity and severe influenza in mouse models. However, the extent of generation of neutrophil extracellular traps (NETs or NETosis) in obese individuals during influenza pneumonia is hitherto unknown. This study investigated pulmonary NETs generation in BALB/c mice fed with high-fat diet (HFD) and low-fat diet (LFD), during the course of influenza pneumonia. Clinical disease progression, histopathology, lung reactive oxygen species, and myeloperoxidase activity were also compared...
2016: Frontiers in Immunology
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