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https://www.readbyqxmd.com/read/28917061/use-of-lipid-emulsion-therapy-in-local-anesthetic-overdose
#1
Ozgur Karcioglu
The use of intravenous lipid emulsion (ILE) therapy as antidote in systemic toxicity of certain agents has gained widespread support. There are increasing data suggesting use of ILE in reversing from local anesthetic-induced systemic toxicity severe, life-threatening cardiotoxicity, although findings are contradictory. Efficiency of ILE was demonstrated in animal studies in the treatment of severe impairment of cardiac functions, via a mechanism for trapping lipophilic drugs in an expanded plasma lipid compartment ("lipid sink")...
October 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28846033/metabolic-alterations-of-qinghai-tibet-plateau-pikas-in-adaptation-to-high-altitude
#2
Xue-Feng Cao, Zhen-Zhong Bai, Lan Ma, Shuang Ma, Ri-Li Ge
Cao, Xue-Feng, Zhen-Zhong Bai, Lan Ma, Shuang Ma, and Ri-Li Ge. Metabolic alterations of Qinghai-Tibet plateau pikas in adaptation to high altitude. High Alt Med Biol. 18:219-225, 2017.-To determine specific metabolic alterations in the myocardium of plateau pikas (Ochotona curzoniae) and potential metabolic biomarkers involved in their adaptation to the high-altitude environment of the Qinghai-Tibet Plateau. Ten pikas were captured by traps in the Kekexili Reserve (4630 m a.s.l; n = 5) and at the foot of the Laji Mountain (2600 m a...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28835390/excessive-vitamin-e-intake-does-not-cause-bone-loss-in-male-or-ovariectomized-female-mice-fed-normal-or-high-fat-diets
#3
Hiroko Ikegami, Rie Kawawa, Ikuyo Ichi, Tomoko Ishikawa, Taisuke Koike, Yoshinori Aoki, Yoko Fujiwara
Background: Animal studies on the effects of vitamin E on bone health have yielded conflicting and inconclusive results, and to our knowledge, no studies have addressed the effect of vitamin E on bone in animals consuming a high-fat diet (HFD).Objective: This study aimed to evaluate the effect of excessive vitamin E on bone metabolism in normal male mice and ovariectomized female mice fed a normal diet (ND) or HFD.Methods: In the first 2 experiments, 7-wk-old male mice were fed an ND (16% energy from fat) containing 75 (control), 0 (vitamin E-free), or 1000 (high vitamin E) mg vitamin E/kg (experiment 1) or an HFD (46% energy from fat) containing 0, 200, 500, or 1000 mg vitamin E/kg (experiment 2) for 18 wk...
August 23, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28815154/spin-trapping-a-review-for-the-study-of-obesity-related-oxidative-stress-and-na-k-atpase
#4
Athar Nawab, Alexandra Nichols, Rebecca Klug, Joseph I Shapiro, Komal Sodhi
Reactive oxygen species (ROS) have gained attention with mounting evidence of their importance in cell signaling and various disease states. ROS is produced continuously as a natural by-product of normal oxygen metabolism. However, high levels ROS causes oxidative stress and damage to biomolecules. This results in loss of protein function, DNA cleavage, lipid peroxidation, or ultimately cell injury or death. Obesity has become a worldwide epidemic; studies show fat accumulation is associated with increased ROS and oxidative stress...
June 2017: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/28814530/a-high-fat-diet-decreases-bone-mass-in-growing-mice-with-systemic-chronic-inflammation-induced-by-low-dose-slow-release-lipopolysaccharide-pellets
#5
Jay J Cao, Brian R Gregoire, Chwan-Li Shen
Background: Chronic inflammation is associated with increased bone resorption and is linked to osteopenia, or low bone mass. Obesity is also associated with low-grade chronic upregulation of inflammatory cytokines.Objective: This study investigated the effect of high-fat (HF) diet-induced obesity on bone structure changes in growing mice with existing systemic chronic inflammation induced by low-dose, slow-release lipopolysaccharide (LPS).Methods: Forty-eight 6-wk-old female C57BL/6 mice were randomly assigned to 4 treatment groups (n = 12/group) in a 2 × 2 factorial design-control (placebo) or LPS treatment (1...
August 16, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28766488/effect-of-high-strength-food-wastes-on-anaerobic-co-digestion-of-sewage-sludge
#6
(no author information available yet)
Anaerobic co-digestion has been practiced at water resource recovery facilities to increase methane production, but theimpact of many variables is still not well understood. In this study, the feasibility of co-digesting fats, oils and grease (FOG) and other high strength wastes (HSWs) with municipal sewage sludge was investigated. Four lab-scale, digesters were operated at a working volume of 9.75 L, 15 day SRT and temperature of 37 oC. Wastes including whey (cheese), juice, grease trap waste (GTW) and dissolved air flotation waste (DAF), along with municipal sewage sludge, were fed to the digesters in varying amounts...
July 6, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28720960/levels-and-formation-of-%C3%AE-dicarbonyl-compounds-in-beverages-and-the-preventive-effects-of-flavonoids
#7
Chen Wang, Yongling Lu, Qiju Huang, Tiesong Zheng, Shengmin Sang, Lishuang Lv
ABSTRACT: Methylglyoxal (MGO) and glyoxal (GO), α-dicarbonyl compounds found in the Maillard reaction, progressively and irreversibly modify proteins. Beverages are an exogenous source of α-dicarbonyl compounds and may potentially increase MGO and GO levels in vivo. Using GC-FID method, we detected the MGO and GO contents of 86 beverages in Chinese supermarkets. The highest MGO and GO 587.5 µg/100 mL and 716.7 µg/100 mL respectively found in soyamilk and coffee. Herbal beverages, which contained bioactive components, had lower average levels of MGO (48...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28704114/orbital-floor-fracture-with-entrapment-imaging-and-clinical-correlations-in-45-cases
#8
Nora Silverman, Jordan Spindle, Sunny X Tang, Andrew Wu, Bryan K Hong, John W Shore, Sara Wester, Flora Levin, Michael Connor, Benjamin Burt, Tanuj Nakra, Todd Shepler, Eric Hink, Tarek El-Sawy, Roman Shinder
Orbital floor fractures (OFF) with entrapment require prompt clinical and radiographic recognition for timely surgical correction. Correct CT radiographic interpretation of entrapped fractures can be subtle and thus missed. We reviewed the clinical, radiographic and intraoperative findings of 45 cases of entrapped OFF to correlate pre- and intraoperative findings with radiography. Retrospective review and statistical analysis of 45 patients with OFF using the chi squared and Kruskal-Wallis tests. Main outcome measures included patient demographics, clinical features, radiologic interpretation, intraoperative findings, and treatment outcomes...
July 13, 2017: Orbit
https://www.readbyqxmd.com/read/28669771/antidiabetic-antioxidant-and-anti-inflammatory-properties-of-water-and-n-butanol-soluble-extracts-from-saharian-anvillea-radiata-in-high-fat-diet-fed-mice
#9
Chouaib Kandouli, Mathieu Cassien, Anne Mercier, Caroline Delehedde, Emilie Ricquebourg, Pierre Stocker, Mourad Mekaouche, Zineb Leulmi, Aicha Mechakra, Sophie Thétiot-Laurent, Marcel Culcasi, Sylvia Pietri
ETHNOPHARMACOLOGICAL RELEVANCE: According to Saharian traditional medicine, Anvillea radiata Coss. & Dur. (Asteraceae) has been valued for treating a variety of ailments such as gastro-intestinal, liver and pulmonary diseases, and has gained awareness for its beneficial effect on postprandial hyperglycemia. However, to best of our knowledge, no detailed study of the antidiabetic curative effects of this plant has been conducted yet. AIM OF THE STUDY: To determine the hypoglycemic and antidiabetic effect of dietary supplementation with Anvillea radiata extracts on high-fat-diet (HFD)-induced obesity and insulin resistance in C57BL/6J mice in relation with antioxidant, anti-inflammatory, pancreatic beta-cells and skeletal muscle protection, and digestive enzyme inhibiting properties...
July 31, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28662609/rapid-degradation-of-fog-discharged-from-food-industry-wastewater-by-lipolytic-fungi-as-a-bioaugmentation-application
#10
Ayoma Witharana, Jagath Manatunge, Niranjanie Ratnayake, Chandrika M Nanayakkara, Mahesh Jayaweera
Fats, oils and grease (FOG) congregate in grease trap devices as a result of culinary activities in the food service industry. FOG is considered to be a slowly biodegradable particulate organic matter and may require enzymatic or hydrolytic conversion to form readily biodegradable soluble organic matter. The existing treatment methods are claimed on water based hydrolysis of FOG to form long chain fatty acids. The long fatty acids discharged into wastewater treatment system create functional difficulties, especially the inhibitory effect caused by accumulation of long chain fatty acids...
June 30, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28606422/effect-of-aerobic-exercise-on-markers-of-bone-metabolism-of-overweight-and-obese-patients-with-chronic-kidney-disease
#11
Tarcisio Santana Gomes, Danilo Takashi Aoike, Flavia Baria, Fabiana G Graciolli, Rosa M A Moyses, Lilian Cuppari
OBJECTIVE: The aim of the study was to investigate the effect of aerobic exercise on markers of bone metabolism in overweight and obese nondialysis-dependent patients with chronic kidney disease. METHODS: This is a post-hoc study with 39 sedentary patients (55.5 ± 8.3 years, body mass index 31.2 ± 4.4 kg/m(2), estimated glomerular filtration rate 26.9 ± 11.7 mL/minute) who were randomly assigned to the aerobic exercise group (n = 24) or the control group (n = 15)...
June 9, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/28551552/standardized-mori-ramulus-extract-improves-insulin-secretion-and-insulin-sensitivity-in-c57blks-j-db-db-mice-and-ins-1-cells
#12
Soo-Yeon Park, Bora Jin, Jae-Ho Shin, Sirichai Adisakwattana, Oran Kwon
Abnormalities in the hyperbolic relationship between insulin sensitivity and insulin secretion may cause oxidative stress and non-enzymatic glycation, resulting in an increased risk of type 2 diabetes. Here, we performed a 14-week study to investigate the effects of ethanolic extract of Mori ramulus (MRE; 0, 800, and 1600mg/kg body weight) and its signature component oxyresveratrol (OXY; 800mg/kg body weight) on β-cell dysfunction and insulin resistance in C57BLKS/J db/db mice fed with a high-fat diet. Compared with the diabetic control group, the high-dose MRE group showed a significant decrease in fasting blood glucose (p=0...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28532220/the-adipokine-tartrate-resistant-acid-phosphatase-5a-in-serum-correlates-to-adipose-tissue-expansion-in-obesity
#13
Christina Patlaka, Laia Mira Pascual, Staffan Paulie, Anni-Frid Henriksson, Peter Arner, Pernilla Lång, Göran Andersson
PURPOSE: Tartrate-resistant acid phosphatase (TRAP) exists as two isoforms, 5a and 5b. TRAP 5a is elevated in adipose tissue of obese women, interacts with pre-adipocytes and is linked to insulin-sensitive hyperplastic obesity when overexpressed in mice. The aim of this study was to investigate the relation between serum TRAP 5a, adiposity indices and metabolic syndrome risk markers in lean and obese women, using a newly developed TRAP 5a-specific ELISA. MATERIALS AND METHODS: A TRAP 5a sandwich ELISA was optimized using TRAP 5a-specific monoclonal antibodies and tested in sera of healthy males...
June 8, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28486336/seasonal-variations-of-bone-metabolism-and-bone-mineral-density-in-collegiate-alpine-skiers
#14
Teruyuki Sato, Keishoku Sakuraba, Yosuke Tsuchiya, Shinya Maruyama, Eisuke Ochi
This study investigated the seasonal variations in bone metabolism, mineral density, and physical characteristics in collegiate alpine skiers. Twelve male subjects (20.6 ± 1.5 years) were evaluated for body composition, body mineral density (BMD), serum levels of osteocalcin (OC), bone alkaline phosphatase (BAP), tartrate-resistant acid phosphatase 5b (TRACP-5b), parathormone, and 25-hydroxyvitamin D (25(OH)D). We also measured the knee extensor and flexor strength, maximal power, and vertical jump. Measurements were conducted in the pre-season period (T1), competitive period (T2), end-of-season period (T3), and resting period (T4)...
May 5, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28468730/the-influence-of-decreased-hydraulic-retention-time-on-the-performance-and-stability-of-co-digestion-of-sewage-sludge-with-grease-trap-sludge-and-organic-fraction-of-municipal-waste
#15
Anna Grosser
The effect of hydraulic retention time ranging from 12 to 20 d on process performance and stability was investigated in two anaerobic completely stirred tank reactors with a working liquid volume equal to 6 litres. The reactors were fed with mixtures containing (on volatile solids basis): 40% of sewage sludge, 30% of organic fraction of municipal waste and 30% of grease trap sludge. The change of hydraulic retention time did not significantly affect process stability. However, methane yields as well as volatile solids removal decreased from 0...
April 30, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28419293/expression-and-enzyme-activity-of-catalase-in-chilo-suppressalis-lepidoptera-crambidae-is-responsive-to-environmental-stresses
#16
Yanhui Lu, Qi Bai, Xusong Zheng, Zhongxian Lu
Catalase (CAT) is an important antioxidant enzyme that protects organisms against oxidative stresses by eliminating hydrogen peroxide. In this study, we cloned and characterized a full-length cDNA of CAT from Chilo suppressalis (CsCAT) and examined the influence of environmental stresses on CsCAT expression and enzyme activity. The cDNA contains a 1659-bp open reading frame encoding a polypeptide of 553 amino acids most closely related (90.14%) to Papilio polytes catalases. The CsCAT was expressed in all developmental stages with the highest expression in the fat body, and the CsCAT enzyme activity closely mirrored its observed mRNA expression patterns...
August 1, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28269728/modeling-and-design-of-antennas-for-implantable-telemetry-applications
#17
Arun Venkatasubramanian, Brandon Gifford
Incorporating an RF communications link in an implanted medical device can increase its range of applicability and improve quality of life for the patient. Developments in support electronics decrease design risk, but the implanted antenna remains a critical component of a communications link that operates at very low received power. Transmitted power is limited both by regulatory restrictions and, for most implanted devices, by power source capacity. Dielectric losses and wave trapping in the body result in transmission losses much greater than seen in free space communications...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28237595/effect-of-short-term-feed-restriction-on-temporal-changes-in-milk-components-and-mammary-lipogenic-gene-expression-in-mid-lactation-holstein-dairy-cows
#18
A M Abdelatty, M E Iwaniuk, M Garcia, K M Moyes, B B Teter, P Delmonte, A K G Kadegowda, M A Tony, F F Mohamad, R A Erdman
Investigations of the temporal changes in mammary gene expression that occur during sudden diet change have been limited by the use of mammary tissue as the source of RNA because of the invasive nature of mammary biopsy procedures. However, the cytosolic crescent, present in 1% of the largest milk fat globules, contains mammary epithelial cell RNA that has become trapped between the inner and outer milk fat globule membranes during final formation and secretion of milk fat into the lumen of the mammary alveoli...
May 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28236130/entrapment-of-the-posterior-femoral-cutaneous-nerve-and-its-inferior-cluneal-branches-anatomical-basis-of-surgery-for-inferior-cluneal-neuralgia
#19
Stéphane Ploteau, Céline Salaud, Antoine Hamel, Roger Robert
PURPOSE: The apparent failure of pudendal nerve surgery in some patients has led us to suggest the possibility of entrapment of other adjacent nerve structures, leading to the concept of inferior cluneal neuralgia. Via its numerous collateral branches, the posterior femoral cutaneous nerve innervates a very extensive territory including the posterior surface of the thigh, the infragluteal fold, the skin over the ischial tuberosity, but also the lateral anal region, scrotum or labium majus via its perineal branch...
February 24, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28227992/modeling-and-design-of-antennas-for-implantable-telemetry-applications
#20
Arun Venkatasubramanian, Brandon Gifford, Arun Venkatasubramanian, Brandon Gifford, Brandon Gifford, Arun Venkatasubramanian
Incorporating an RF communications link in an implanted medical device can increase its range of applicability and improve quality of life for the patient. Developments in support electronics decrease design risk, but the implanted antenna remains a critical component of a communications link that operates at very low received power. Transmitted power is limited both by regulatory restrictions and, for most implanted devices, by power source capacity. Dielectric losses and wave trapping in the body result in transmission losses much greater than seen in free space communications...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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