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https://www.readbyqxmd.com/read/28430854/dynamic-modeling-and-network-approaches-for-omics-time-course-data-overview-of-computational-approaches-and-applications
#1
Yulan Liang, Arpad Kelemen
Inferring networks and dynamics of genes, proteins, cells and other biological entities from high-throughput biological omics data is a central and challenging issue in computational and systems biology. This is essential for understanding the complexity of human health, disease susceptibility and pathogenesis for Predictive, Preventive, Personalized and Participatory (P4) system and precision medicine. The delineation of the possible interactions of all genes/proteins in a genome/proteome is a task for which conventional experimental techniques are ill suited...
April 18, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28391973/the-current-status-and-problems-confronted-in-delivering-precision-medicine-in-japan-and-europe
#2
REVIEW
Hideaki Bando
Precision medicine has been defined as "a predictive, preventive, personalized, and participatory health care service delivery model." Today, developments in next-generation sequencing and information technology have made precision medicine possible, with massive amounts of genetic, "omics," clinical, environmental, and lifestyle data now available. Unfortunately, differences in governmental support and health care regulations have resulted in heterogeneous progress among countries. In Japan, for example, precision cancer screening and treatments are increasingly being promoted, with collaboration among research, governmental, and pharmaceutical agencies taking place in the nationwide SCRUM-Japan cancer genome screening project...
February 22, 2017: Current Problems in Cancer
https://www.readbyqxmd.com/read/28386099/participatory-simulation-modelling-to-inform-public-health-policy-and-practice-rethinking-the-evidence-hierarchies
#3
Eloise O'Donnell, Jo-An Atkinson, Louise Freebairn, Lucie Rychetnik
Drawing on the long tradition of evidence-based medicine that aims to improve the efficiency and effectiveness of clinical practice, the field of public health has sought to apply 'hierarchies of evidence' to appraise and synthesise public health research. Various critiques of this approach led to the development of synthesis methods that include broader evidence typologies and more 'fit for purpose' privileging of methodological designs. While such adaptations offer great utility for evidence-informed public health policy and practice, this paper offers an alternative perspective on the synthesis of evidence that necessitates a yet more egalitarian approach...
April 6, 2017: Journal of Public Health Policy
https://www.readbyqxmd.com/read/28356752/value-as-the-key-concept-in-the-health-care-system-how-it-has-influenced-medical-practice-and-clinical-decision-making-processes
#4
Chiara Marzorati, Gabriella Pravettoni
In the last 10 years, value has played a key role in the health care system. In this concept, innovations in medical practice and the increasing importance of patient centeredness have contributed to draw the attention of the medical community. Nonetheless, a large consensus on the meaning of "value" is still lacking: patients, physicians, policy makers, and other health care professionals have different ideas on which component of value may play a prominent role. Yet, shared clinical decision-making and patient empowerment have been recognized as fundamental features of the concept of value...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/28329560/patient-provider-communication-concordance-and-ratings-of-care-in-dermatology-results-of-a-cross-sectional-study
#5
Valerie M Harvey, Uchechukwu Ozoemena, Joan Paul, Hind A Beydoun, Nashay N Clemetson, Ginette A Okoye
ObjectiveTo determine the impact of race concordance on patient perception of quality of dermatologic care.Study designCross-sectional study.SettingAcademic outpatient practices in the Departments of Dermatology of Eastern Virginia Medical School and the Johns Hopkins University School of Medicine.ParticipantsThe study cohort comprised 124 participants including 6 providers and 118 established patients.Main Outcome MeasuresWe hypothesized, a priori, that patients in race-discordant dyads would report lower ratings of participatory decision-making (PDM), satisfaction, trust in the provider, and similarities with providers...
November 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28294320/nursing-clinical-practice-changes-to-improve-self-management-in-chronic-obstructive-pulmonary-disease
#6
J M Padilha, P A F Sousa, F M S Pereira
AIM: To propose nursing clinical practice changes to improve the development of patient self-management. BACKGROUND: Chronic obstructive pulmonary disease is one of the main causes of chronic morbidity, loss of quality of life and high mortality rates. INTRODUCTION: Control of the disease's progression, the preservation of autonomy in self-care and maintenance of quality of life are extremely challenging for patients to execute in their daily living...
March 13, 2017: International Nursing Review
https://www.readbyqxmd.com/read/28270929/changing-paradigms-in-the-management-of-rejection-in-kidney-transplantation-evolving-from-protocol-based-care-to-the-era-of-p4-medicine
#7
Mirela Maier, Tomoko Takano, Ruth Sapir-Pichhadze
PURPOSE OF REVIEW: P4 medicine denotes an evolving field of medicine encompassing predictive, preventive, personalized, and participatory medicine. Using the example of kidney allograft rejection because of donor-recipient incompatibility in human leukocyte antigens, this review outlines P4 medicine's relevance to the various stages of the kidney transplant cycle. SOURCES OF INFORMATION: A search for English articles was conducted in Medline via OvidSP (up to August 18, 2016) using a combination of subject headings (MeSH) and free text in titles, abstracts, and author keywords for the concepts kidney transplantation and P4 medicine...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28209684/medicine-inside-prisons-participatory-research-and-practising-with-hope-behind-bars
#8
Sarah de Leeuw
No abstract text is available yet for this article.
February 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28188946/integration-of-cognitive-skills-as-a-cross-cutting-theme-into-the-undergraduate-medical-curriculum-at-tehran-university-of-medical-sciences
#9
Akbar Soltani, Maryam Allaa, Hamideh Moosapour, Azadeh Aletaha, Farzaneh Shahrtash, Alireza Monajemi, Tohid Arastoo, Maryam Ahmadinejad, Azim Mirzazadeh, Mahboobeh Khabaz Mafinejad
Nowadays, improvement of thinking skills of students is one of the universally supported aims in the majority of medical schools. This study aims to design longitudinal theme of reasoning, problem-solving and decision-making into the undergraduate medical curriculum at Tehran University of Medical Sciences (TUMS). A participatory approach was applied to design the curriculum during 2009-2011. The project was conducted by the contribution of representatives of both basic and clinical faculty members, students and graduates at Tehran University of Medical Sciences...
January 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28179216/navigating-ethics-in-the-digital-age-introducing-connected-and-open-research-ethics-core-a-tool-for-researchers-and-institutional-review-boards
#10
John Torous, Camille Nebeker
Research studies that leverage emerging technologies, such as passive sensing devices and mobile apps, have demonstrated encouraging potential with respect to favorably influencing the human condition. As a result, the nascent fields of mHealth and digital medicine have gained traction over the past decade as demonstrated in the United States by increased federal funding for research that cuts across a broad spectrum of health conditions. The existence of mHealth and digital medicine also introduced new ethical and regulatory challenges that both institutional review boards (IRBs) and researchers are struggling to navigate...
February 8, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28155322/an-assessment-of-implementation-of-communityoriented-primary-care-in-kenyan-family-medicine-postgraduate-medical-education-programmes
#11
Ian J Nelligan, Jacob Shabani, Stephanie Taché, Gulnaz Mohamoud, Megan Mahoney
BACKGROUND AND OBJECTIVES: Family medicine postgraduate programmes in Kenya are examining the benefits of Community-Oriented Primary Care (COPC) curriculum, as a method to train residents in population-based approaches to health care delivery. Whilst COPC is an established part of family medicine training in the United States, little is known about its application in Kenya. We sought to conduct a qualitative study to explore the development and implementation of COPC curriculum in the first two family medicine postgraduate programmes in Kenya...
December 2, 2016: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/28152741/quality-improvement-strategies-in-medical-oncology-a-qualitative-analysis-from-a-scoping-review
#12
Laavanya Dharmakulaseelan, Simron Singh, Adam E Haynes, Brian M Wong, Matthew C Cheung
203 Background: In 2001, the Institute of Medicine (IOM) outlined imperatives to improve quality of care. Quality improvement (QI) has since become essential to cancer care but barriers still exist to the publication of and participation in QI initiatives, including limited recognition for QI and uncertainty with methodologies. We sought to identify strategies used in QI in scholarly medical oncology literature to provide practical guidance for QI. METHODS: We conducted a scoping review using Arksey and O'Malley's framework...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28074382/engaging-hmong-adults-in-genomic%C3%A2-and%C3%A2-pharmacogenomic-research-toward-reducing-health-disparities-in-genomic-knowledge-using-a-community-based-participatory-research-approach
#13
Kathleen A Culhane-Pera, Robert J Straka, MaiKia Moua, Youssef Roman, Pachia Vue, Kang Xiaaj, May Xia Lo, Mai Lor
Advancing precision medicine relies in part on examining populations that may exhibit unique genetic variants that impact clinical outcomes. Failure to include diverse populations in genomic-based research represents a health disparity. We implemented a community-based participatory research (CBPR) process with the Hmong community in Minnesota, who were refugees from Laos, in order to assess the feasibility of conducting genomic and pharmacogenomic-based research for genetic variants that are relevant to the Hmong community...
January 10, 2017: Journal of Community Genetics
https://www.readbyqxmd.com/read/28026910/participatory-policy-making-by-dairy-producers-to-reduce-anti-microbial-use-on-farms
#14
L van Dijk, A Hayton, D C J Main, A Booth, A King, D C Barrett, H J Buller, K K Reyher
Pressures for more responsible use of anti-microbial (AM) medicines in food animals are likely to increase from policymakers and the food industry, including retailers. To address this challenge, participatory approaches to welfare interventions and disease prevention may also be necessary alongside more conventional regulatory measures. This article describes the process of enabling groups of dairy producers to use a participatory policy making approach to develop an AM stewardship policy. The policy includes measures agreed to by all producers for more responsible use of AMs, whilst maintaining or improving dairy herd health and welfare...
December 27, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27997259/a-new-comprehensive-model-for-continuous-professional-development
#15
Niels Kristian Kjaer, Marianne Vedsted, James Høpner
BACKGROUND: It is generally agreed that continuing professional development (CPD) for GPs is important for quality of care. Internationally, however, different approaches to identify the learning objectives and the CPD content have been chosen. OBJECTIVES: To improve GPs' CPD in Denmark we explore how general practitioners' (GPs) self-experienced learning needs can be combined with learning needs experienced from a societal perspective and still make sense for GPs...
December 20, 2016: European Journal of General Practice
https://www.readbyqxmd.com/read/27976667/icoh-international-code-of-ethics-for-occupational-health-professionals-historical-fortune-and-future-perspectives-in-italy
#16
Carlo Petyx, Giovanni Costa, Maurizio Manno, Antonio Valenti, Sergio Iavicoli
The Working Group responsible for the Italian translation of the third edition of the International Code of Ethics, appointed by the President of the International Commission on Occupational Health (ICOH), Dr. Jukka Takala, completed last April the revision work. The final text, already available on the ICOH website, has been printed and distributed by the Italian National Institute for Insurance against Accidents at Work (INAIL) at the 79th National Congress of the Italian Society of Occupational Medicine and Industrial Hygiene (SIMLII), in Rome...
December 13, 2016: La Medicina del Lavoro
https://www.readbyqxmd.com/read/27940512/announcements-versus-conversations-to-improve-hpv-vaccination-coverage-a-randomized-trial
#17
Noel T Brewer, Megan E Hall, Teri L Malo, Melissa B Gilkey, Beth Quinn, Christine Lathren
OBJECTIVE: Improving provider recommendations is critical to addressing low human papillomavirus (HPV) vaccination coverage. Thus, we sought to determine the effectiveness of training providers to improve their recommendations using either presumptive "announcements" or participatory "conversations." METHODS: In 2015, we conducted a parallel-group randomized clinical trial with 30 pediatric and family medicine clinics in central North Carolina. We randomized clinics to receive no training (control), announcement training, or conversation training...
January 2017: Pediatrics
https://www.readbyqxmd.com/read/27873024/p4%C3%A2-medicine-and-osteoporosis-a%C3%A2-systematic-review
#18
REVIEW
Klemen Kodrič, Klemen Čamernik, Darko Černe, Radko Komadina, Janja Marc
BACKGROUND: Osteoporosis is the most frequent bone metabolic disease. In order to improve early detection, prediction, prevention, diagnosis, and treatment of the disease, a new model of P4 medicine (personalized, predictive, preventive, and participatory medicine) could be applied. The aim of this work was to systematically review the publications of four different types of "omics" studies related to osteoporosis, in order to discover novel predictive, preventive, diagnostic, and therapeutic targets for better management of the geriatric population...
December 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27864206/educational-strategies-to-enable-expansion-of-pharmacogenomics-based-care
#19
Kristin Wiisanen Weitzel, Christina L Aquilante, Samuel Johnson, David F Kisor, Philip E Empey
PURPOSE: The current state of pharmacogenomics education for pharmacy students and practitioners is discussed, and resources and strategies to address persistent challenges in this area are reviewed. SUMMARY: Consensus-based pharmacist competencies and guidelines have been published to guide pharmacogenomics knowledge attainment and application in clinical practice. Pharmacogenomics education is integrated into various pharmacy school courses and, increasingly, into Pharm...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27822876/leaves-imitate-trees-minnesota-hmong-concepts-of-heredity-and-applications-to-genomics-research
#20
Kathleen A Culhane-Pera, MaiKia Moua, Pachia Vue, Kang Xiaaj, May Xia Lo, Robert J Straka
Historically, Hmong refugees in the USA were distrustful of Western medicine, medicines, and medical research due to concerns about harm and experimentation. Current Hmong concerns about genomics research are not well known. Our research aims were to identify cultural and ethical issues about conducting genomic studies in the Hmong community. Using a community-based participatory action process, the West Side Hmong Genomics Research Board conducted a qualitative exploratory research study that included semistructured interviews with five Hmong key informants and five focus groups with 42 Hmong adults near Saint Paul, Minnesota...
January 2017: Journal of Community Genetics
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