keyword
https://read.qxmd.com/read/38143086/epigenetic-alterations-of-11beta-hydroxysteroid-dehydrogenase-1-gene-in-the-adipose-tissue-of-patients-with-primary-aldosteronism
#21
JOURNAL ARTICLE
Yoshimichi Takeda, Masashi Demura, Mitsuhiro Kometani, Shigehiro Karashima, Daisuke Aono, Seigo Konishi, Shin-Ichi Horike, Makiko Meguro-Horike, Takashi Yoneda, Yoshiyu Takeda
11Beta-hydroxysteroid dehydrogenase 1 (11β-HSD1) is a key enzyme involved in metabolic syndrome. Transcript-specific epigenetic regulation of the gene encoding 11β-HSD1 (HSD11B1) has been reported. We examined the mRNA level and methylation status of the HSD11B1 promoter region in the adipose tissue of patients with primary aldosteronism (PA). We compared 10 tissue specimens from patients with PA caused by aldosterone-producing adenoma (APA) with 8 adipose tissue specimens from patients with subclinical Cushing's syndrome (SCS) caused by cortisol-producing adenomas, 4 tissue specimens from patients with Cushing's adenoma (Cu), or 7 tissue specimens from patients with non-functioning adrenal adenoma (NFA)...
December 22, 2023: Endocrine Journal
https://read.qxmd.com/read/38136073/practice-variation-among-pediatric-endocrinologists-in-the-dosing-of-glucocorticoids-in-young-children-with-congenital-adrenal-hyperplasia
#22
JOURNAL ARTICLE
Heba Al-Rayess, Amit Lahoti, Leslie Long Simpson, Elise Palzer, Paul Thornton, Ryan Heksch, Manmohan Kamboj, Takara Stanley, Molly O Regelmann, Anshu Gupta, Vandana Raman, Shilpa Mehta, Mitchell E Geffner, Kyriakie Sarafoglou
A Pediatric Endocrine Society (PES) Drugs and Therapeutics Committee workgroup sought to determine the prescribing practices of pediatric endocrinologists when treating children <10 years of age with congenital adrenal hyperplasia (CAH). Our workgroup administered a 32-question online survey to PES members. There were 187 respondents (88.9% attending physicians), mostly from university-affiliated clinics (~80%). Ninety-eight percent of respondents prescribed the short-acting glucocorticoid hydrocortisone to treat young children, as per the Endocrine Society CAH Guidelines, although respondents also prescribed long-acting glucocorticoids such as prednisolone suspension (12%), prednisone tablets (9%), and prednisone suspension (6%)...
November 29, 2023: Children
https://read.qxmd.com/read/38134337/diagnosis-and-management-of-osteoporosis-a-comprehensive-review-of-guidelines
#23
REVIEW
Elpiniki Rentzeperi, Stavroula Pegiou, Ioannis Tsakiridis, Ioannis Kalogiannidis, Anargyros Kourtis, Apostolos Mamopoulos, Apostolos Athanasiadis, Themistoklis Dagklis
IMPORTANCE: Osteoporosis causes increased morbidity and mortality, and thus poses a significant economic burden to the health systems worldwide. OBJECTIVE: The aim of this study was to review and compare the most recently published major guidelines on diagnosis and management of this common medical entity. EVIDENCE ACQUISITION: A thorough comparative review of the most influential guidelines from the RACGP (Royal Australian College of General Practitioners), the ESCEO-IOF (European Society for Clinical and Economic Aspects of Osteoporosis-International Osteoporosis Foundation), the NOGG (National Osteoporosis Guideline Group), the NAMS (North American Menopause Society), the ES (Endocrine Society), and the ACOG (American College of Obstetricians and Gynecologists) was conducted...
November 2023: Obstetrical & Gynecological Survey
https://read.qxmd.com/read/38123337/definition-criteria-and-core-concepts-of-guidelines-for-the-management-of-obesity-disease-in-japan
#24
JOURNAL ARTICLE
Wataru Ogawa, Yushi Hirota, Shigeru Miyazaki, Tadashi Nakamura, Yoshihiro Ogawa, Iichiro Shimomura, Toshimasa Yamauchi, Koutaro Yokote
To identify those who might benefit from weight reduction within a large population of obese individuals, Japan Society for the Study of Obesity (JASSO) advocated the concept of "obesity disease." Here we summarize the definition, criteria, and core concepts for the management of obesity disease based on JASSO's latest guideline. JASSO defines obesity as excessive fat storage in adipose tissue associated with a BMI of ≥25 kg/m2 . The threshold BMI of obesity is low as compared to Western countries given that Japanese individuals tend to develop obesity-related health disorders at lower BMI...
December 20, 2023: Endocrine Journal
https://read.qxmd.com/read/38090229/using-animal-models-for-gender-affirming-hormone-therapy
#25
JOURNAL ARTICLE
Krisha Aghi, Teddy G Goetz, Daniel R Pfau, Simón E D Sun, Eartha Mae Guthman, Troy A Roepke
We have recently proposed experimental design guidelines and areas of study for preclinical rodent models of gender-affirming hormone therapy in neuroscience. These guidelines also apply to any field subject to the influences of gonadal steroid hormones, including metabolism and growth, cancer, and physiology. This perspective briefly describes our suggestions for these fields. Studying the effects of exogenous steroid hormones will have translational benefits for the community. We also discuss the need for equitable practices for cisgender scientists who wish to implement these guidelines and engage with the community...
December 1, 2023: Journal of the Endocrine Society
https://read.qxmd.com/read/38077545/skeletal-age-evaluation-using-hand-x-rays-to-determine-growth-problems
#26
JOURNAL ARTICLE
Muhammad Umer, Ala' Abdulmajid Eshmawi, Khaled Alnowaiser, Abdullah Mohamed, Huda Alrashidi, Imran Ashraf
A common clinical method for identifying anomalies in bone growth in infants and newborns is skeletal age estimation with X-ray images. Children's bone abnormalities can result from several conditions including wounds, infections, or tumors. One of the most frequent reasons for bone issues is that most youngsters are affected by the slow displacement of bones caused by pressure applied to the growth plates as youngsters develop. The growth plate can be harmed by a lack of blood supply, separation from other parts of the bone, or slight misalignment...
2023: PeerJ. Computer Science
https://read.qxmd.com/read/38073517/polycystic-ovary-syndrome-associations-with-cardiovascular-disease
#27
REVIEW
J L Benham, A Goldberg, H Teede, C T Tay
Polycystic ovary syndrome (PCOS), characterized by abnormal menstrual periods, elevated androgen levels and polycystic ovary morphology on ultrasound, is the most common endocrine disorder among females. PCOS is associated with cardiovascular disease (CVD) risk factors including diabetes, obesity, metabolic syndrome, adverse pregnancy outcomes such as pre-eclampsia and psychosocial distress including depression. Previous evidence on the association between PCOS and CVD is inconclusive but the latest 2023 International Evidence-Based PCOS Guideline identifies PCOS as a risk factor for CVD...
December 11, 2023: Climacteric: the Journal of the International Menopause Society
https://read.qxmd.com/read/38048417/brazilian-evidence-based-guideline-for-screening-diagnosis-treatment-and-follow-up-of-metabolic-dysfunction-associated-steatotic-liver-disease-masld-in-adult-individuals-with-overweight-or-obesity-a-joint-position-statement-from-the-brazilian-society-of-endocrinology
#28
REVIEW
Rodrigo Oliveira Moreira, Cynthia Melissa Valerio, Cristiane Alves Villela-Nogueira, Cintia Cercato, Fernando Gerchman, Ana Maria Pita Lottenberg, Amélio Fernando Godoy-Matos, Ricardo de Andrade Oliveira, Carlos Eduardo Brandão Mello, Mãrio Reis Álvares-da-Silva, Nathalie Carvalho Leite, Helma Pinchemel Cotrim, Edison Roberto Parisi, Giovanni Faria Silva, Paulo Augusto Carvalho Miranda, Bruno Halpern, Claudia Pinto Oliveira
INTRODUCTION: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as Nonalcoholic fatty liver disease (NAFLD), is one of the most common hepatic diseases in individuals with overweight or obesity. In this context, a panel of experts from three medical societies was organized to develop an evidence-based guideline on the screening, diagnosis, treatment, and follow-up of MASLD. MATERIAL AND METHODS: A MEDLINE search was performed to identify randomized clinical trials, meta-analyses, cohort studies, observational studies, and other relevant studies on NAFLD...
November 27, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38045671/effect-of-yoga-and-walking-on-glycemic-control-for-the-management-of-type-2-diabetes-a-systematic-review-and-meta-analysis
#29
REVIEW
Biswajit Dhali, Sridip Chatterjee, Sudip Sundar Das, Mary D Cruz
BACKGROUND: A daily habit of yogic practice or walking, along with an oral hypoglycemic agent (OHA) could be beneficial for better control of type 2 diabetes mellitus (T2DM). We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to find out the efficiency of yoga or walking on glycemic control in T2DM. METHODOLOGY: The present systematic review and meta-analysis were completed according to the PRISMA guidelines. The risk of bias in included studies was evaluated, by using the revised Cochrane risk-of-bias tool for randomized trials...
2023: Journal of the ASEAN Federation of Endocrine Societies
https://read.qxmd.com/read/38045667/the-efficacy-and-safety-of-myo-inositol-supplementation-for-the-prevention-of-gestational-diabetes-mellitus-in-overweight-and-obese-pregnant-women-a-systematic-review-and-meta-analysis
#30
REVIEW
Patricia Ann Factor, Hannah Corpuz
BACKGROUND: Myo-inositol has emerged as one of the preventive therapies for the development of gestational diabetes mellitus in at-risk populations. This systematic review and meta-analysis was conducted to determine the efficacy and safety of myo-inositol in decreasing the incidence of gestational diabetes in overweight and obese pregnant women. METHODOLOGY: This meta-analysis was conducted using the standard Cochrane methodology and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) 2020 guidelines...
2023: Journal of the ASEAN Federation of Endocrine Societies
https://read.qxmd.com/read/38040992/critical-care-management-of-patients-after-cardiac-arrest-a-scientific-statement-from-the-american-heart-association-and-neurocritical-care-society
#31
JOURNAL ARTICLE
Karen G Hirsch, Benjamin S Abella, Edilberto Amorim, Mary Kay Bader, Jeffrey F Barletta, Katherine Berg, Clifton W Callaway, Hans Friberg, Emily J Gilmore, David M Greer, Karl B Kern, Sarah Livesay, Teresa L May, Robert W Neumar, Jerry P Nolan, Mauro Oddo, Mary Ann Peberdy, Samuel M Poloyac, David Seder, Fabio Silvio Taccone, Anezi Uzendu, Brian Walsh, Janice L Zimmerman, Romergryko G Geocadin
The critical care management of patients after cardiac arrest is burdened by a lack of high-quality clinical studies and the resultant lack of high-certainty evidence. This results in limited practice guideline recommendations, which may lead to uncertainty and variability in management. Critical care management is crucial in patients after cardiac arrest and affects outcome. Although guidelines address some relevant topics (including temperature control and neurological prognostication of comatose survivors, 2 topics for which there are more robust clinical studies), many important subject areas have limited or nonexistent clinical studies, leading to the absence of guidelines or low-certainty evidence...
December 1, 2023: Neurocritical Care
https://read.qxmd.com/read/38024652/the-degree-of-prepregnancy-vitamin-d-deficiency-is-not-associated-with-gestational-diabetes-in-women-undergoing-art
#32
JOURNAL ARTICLE
Yvonne Liu, Johann-Georg Hocher, Huijun Chen, Liang Hu, Xiaoli Zhang, Sufen Cai, Sha Tang, Fei Gong, Bernhard K Krämer, Ge Lin, Berthold Hocher
CONTEXT: Gestational diabetes mellitus (GDM) is a common pregnancy complication, particularly in women undergoing assisted reproductive technology (ART). An association of GDM with vitamin D in women conceiving naturally has been described; however, studies have yielded heterogeneous results. OBJECTIVE: To analyze the association between prepregnancy total and free vitamin D and GDM incidence in women undergoing ART. METHODS: Post hoc analysis of a prospective study at the Reproductive and Genetic Hospital of CITIC-Xiangya in Changsha, China...
November 2, 2023: Journal of the Endocrine Society
https://read.qxmd.com/read/38014539/critical-care-management-of-patients-after-cardiac-arrest-a-scientific-statement-from-the-american-heart-association-and-neurocritical-care-society
#33
REVIEW
Karen G Hirsch, Benjamin S Abella, Edilberto Amorim, Mary Kay Bader, Jeffrey F Barletta, Katherine Berg, Clifton W Callaway, Hans Friberg, Emily J Gilmore, David M Greer, Karl B Kern, Sarah Livesay, Teresa L May, Robert W Neumar, Jerry P Nolan, Mauro Oddo, Mary Ann Peberdy, Samuel M Poloyac, David Seder, Fabio Silvio Taccone, Anezi Uzendu, Brian Walsh, Janice L Zimmerman, Romergryko G Geocadin
The critical care management of patients after cardiac arrest is burdened by a lack of high-quality clinical studies and the resultant lack of high-certainty evidence. This results in limited practice guideline recommendations, which may lead to uncertainty and variability in management. Critical care management is crucial in patients after cardiac arrest and affects outcome. Although guidelines address some relevant topics (including temperature control and neurological prognostication of comatose survivors, 2 topics for which there are more robust clinical studies), many important subject areas have limited or nonexistent clinical studies, leading to the absence of guidelines or low-certainty evidence...
November 28, 2023: Circulation
https://read.qxmd.com/read/37994586/thyroid-nodule-core-needle-biopsy-current-approach
#34
JOURNAL ARTICLE
Emrah Karatay, Mirkhalig Javadov, Hatice Kaya
Fine needle aspiration biopsy (FNAB) guided by ultrasonography is routinely used to identify thyroid nodules prior to surgery. Although FNAB has great diagnostic accuracy and safety, it is limited by its relatively low diagnostic accuracy in follicular lesions, such as non-diagnostic or atypia of unclear significance (AUS)/follicular lesion of uncertain significance (FLUS). Additional diagnostic tests are required to overcome these challenges in evaluating thyroid nodules. Thyroid nodules can now be diagnosed with spring-activated single- or double-action needles following the introduction of core needle biopsy (CNB)...
November 23, 2023: Endokrynologia Polska
https://read.qxmd.com/read/37902335/the-2023-practitioner-s-toolkit-for-managing-menopause
#35
REVIEW
S R Davis, S Taylor, C Hemachandra, K Magraith, P R Ebeling, F Jane, R M Islam
OBJECTIVE: The Practitioner's Toolkit for Managing the Menopause, developed in 2014, provided an accessible desk-top tool for health-care practitioners caring for women at midlife. To ensure the Toolkit algorithms and supporting information reflect current best practice, the Toolkit has been revised in accordance with the published literature. METHODS: A systematic search for guidelines, position and consensus statements pertaining to the menopause and published after 2014 was undertaken, and key recommendations extracted from the Clinical Practice Guidelines determined to be the most robust by formal evaluation...
December 2023: Climacteric: the Journal of the International Menopause Society
https://read.qxmd.com/read/37900394/a-successful-pregnancy-outcome-after-continued-surveillance-of-lupus-anticoagulant-antibodies-in-a-patient-with-recurrent-pregnancy-loss-a-case-report-and-literature-review
#36
Hannah Flagstad, Tori E Abdalla, Yasmina Sultan, Pedro Mastrodomenico, Ellen G Wood
Recurrent pregnancy loss (RPL) can be a devastating experience for individuals trying to have children. Various potential causes contribute to the multifactorial pathogenesis of RPL, including chromosomal anomalies, endocrine conditions, autoimmunity, thrombophilias, and infectious agents. Antinuclear antibodies (ANAs) offer an unspecific clue to the underlying autoimmune pathogenic etiology of RPL. This case details a 40-year-old female with a history of RPL, fibromyalgia, and ANA positivity, who spontaneously developed lupus anticoagulant antibodies during her second trimester of pregnancy...
September 2023: Curēus
https://read.qxmd.com/read/37897111/hypertension-in-the-emergency-department-a-missed-opportunity-to-screen-for-primary-aldosteronism
#37
JOURNAL ARTICLE
Rachel D Graven, Ignatius Lee, Jing Ren, Jun Yang, Diana Egerton-Warburton
OBJECTIVES: Primary aldosteronism (PA) is a common but under-diagnosed secondary cause of hypertension. Emergency departments (EDs) often assess patients with severe hypertension or its sequelae, some of whom have underlying PA. We aimed to determine the proportion of patients presenting to the ED with hypertension who meet the Endocrine Society criteria for PA testing, and the proportion who were screened. METHODS: We performed a structured retrospective chart review of adults who presented to three EDs in an Australian tertiary health network between August 2019 and February 2020, with a coded presenting complaint of hypertension...
October 28, 2023: Academic Emergency Medicine
https://read.qxmd.com/read/37888878/homeostasis-model-assessment-of-%C3%AE-cell-function-for-diagnosis-of-insulinoma
#38
JOURNAL ARTICLE
Kálmán Bódis, Martin Schön, Laura Dauben, Miriam Wilker, Klaus Strassburger, Volker Burkart, Michael Roden, Karsten Müssig
CONTEXT: Diagnosis of insulinoma is based on different criteria from the 72-hour fasting test according to current guidelines (Endocrine Society [ES], European [ENETS], and North American [NANETS] Neuroendocrine Tumor Societies), including assessment of β-cell function by glucagon stimulation test. OBJECTIVE: This study tested whether the homeostasis model assessment of insulin secretion, including assessment of β-cell function, (HOMA-B) at the end of the fasting test provides comparable efficacy for insulinoma diagnosis...
February 20, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/37877855/adrenal-incidentaloma-controversial-size-recommendations
#39
JOURNAL ARTICLE
Brandon S Jackson
The size of adrenal incidentalomas has important implications for diagnosis and management. Recommendations from endocrine societies do not all correlate with regard to adrenal incidentaloma size. Therefore, the aim was to compare adrenal incidentaloma size recommendations between different endocrine societies and the reasoning for these recommendations. Eight different international guidelines were reviewed and compared. The smaller the size of the incidentaloma, the lower the risk for malignancy. The majority of guidelines consider 4 cm as the cut-off, but there are discrepancies...
March 2023: Urol Res Pract
https://read.qxmd.com/read/37877341/european-neuroendocrine-tumour-society-enets-2023-guidance-paper-for-nonfunctioning-pancreatic-neuroendocrine-tumours
#40
JOURNAL ARTICLE
Beata Kos-Kudła, Justo P Castaño, Timm Denecke, Enrique Grande, Andreas Kjaer, Anna Koumarianou, Louis de Mestier, Stefano Partelli, Aurel Perren, Stefan Stättner, Juan W Valle, Nicola Fazio
This ENETS guidance paper for well-differentiated nonfunctioning pancreatic neuroendocrine tumours (NF-Pan-NET) has been developed by a multidisciplinary working group, and provides up-to-date and practical advice on the management of these tumours. Using the extensive experience of centres treating patients with NF-Pan-NEN, the authors of this guidance paper discuss 10 troublesome questions in everyday clinical practice. Our many years of experience in this field are still being verified in the light of the results of new clinical, which set new ways of proceeding in NEN...
December 2023: Journal of Neuroendocrinology
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