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M Cioch, D Jawniak, M Wach, J Mańko, K Radomska, H Borowska, A Szczepanek, M Hus
BACKGROUND: Hematopoietic stem cell transplantation (HSCT) remains the most efficacious therapy in patients with acute leukemia. For older patients and those lacking a related HLA-compatible donor, autologous transplantation (auto-HSCT) is a valid alternative therapeutic option. METHODS: From 1997 until 2014 in the Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, Poland, 29 auto-HSCT were performed in patients with acute myeloid leukemia (AML; 15 men and 14 women; median age, 52...
June 2016: Transplantation Proceedings
Pavel Polák, Miroslav Penka, Petr Smejkal, Gabriela Chlupová
UNLABELLED: Rituximab, a monoclonal antibody against the surface antigen of B-lymphocytes CD20 is beeing used in the treatment of numerous hematological, hematooncological and autoimmune disorders. After administration of ritu-ximab, quick and almost complete depletion of B-lymphocytes with the exception of pre-B-lymphocytes and plasma cells occur. Neutropenia and low serum antibody levels in classes IgA, IgM and IgG may also develop. These changes usually persist for 6-12 months, rarely for several years...
2016: Vnitr̆ní Lékar̆ství
Patrik Flodr, Pavla Látalová, Martin Tichý, Zuzana Kubová, Tomáš Papajík, Michaela Šváchová, Lenka Radová, Marie Jarošová
The experimental platform in hematooncology is still searching for more valid prognostic and predictive factors on clinical, morphological and molecular levels. The bridge closer to daily practice is so-called translation medicine and from this point of view we have tried to sort diffuse large B-cell lymphoma not otherwise specified. The applied methodological approaches are morphology, indirect immunohistochemistry on formaline-fixed, parrafin-embeded tissue, Hans classifier sorting, expression of Bcl-2, CD5, CD20, CD30 and NfκB proteins in comparison with the clinical (Ann Arbor stage, IPI, aa-IPI, PFS, OS), laboratory and cytogenetic results (complex and simplex karyotypes)...
2016: Ceskoslovenská Patologie
In Kyung Youn, Soo Ah Im, Jae Wook Lee, Nak Gyun Chung, Bin Cho
To find a relationship between clinical and sonographic appearance of hemorrhagic cystitis (HC) in pediatric hematooncology patients. Clinical and sonographic findings of 31 children (M:F = 18:13; mean age, 12.7 years) with HC in pediatric hematooncology patients were reviewed. For each patient, the onset of HC after transplantation, use of bladder-toxic agent, presence of BK viruria, and duration of disease were reviewed. Sonographic findings including bladder wall thickness (BWT), the type of bladder wall thickening (nodular vs...
2015: SpringerPlus
Minna Voigtlaender, Birthe Vogler, Martin Trepel, Jens Panse, Roman Jung, Carsten Bokemeyer, Ulrike Bacher, Mascha Binder
Monoclonal B-cell lymphocytosis (MBL) and monoclonal gammopathy of undetermined significance (MGUS) result from clonal expansions of mature B or plasma cells. Here, we set out to determine the immunophenotypic/monoclonal immunoglobulin (M protein) features and co-prevalence of MBL and MGUS in a hospital-based cohort of 1909 non-hematooncological patients. Of the evaluable cases, 3.8 % showed evidence for MBL by immunophenotyping, while 9.8 % were screened positive for M protein by immunofixation. With six concomitant cases (0...
September 2015: Annals of Hematology
Arkadiusz Macheta, Sylwia Chocholska, Monika Podhorecka
The development of various analitic techniques like classical cytogenetics, molecular cytogenetics and molecular methods has greatly improved our ability to understand the basis of cancer development, that can be helpful in hematological diagnostics and treatment. Thus, improving these methods and raising the diagnostic standards remain of key importance in haematooncology. The influence of cytogenetic and biomolecular analysies on clinical decisions has increased considerably recently, but laboratory techniques have to be optimized to provide reliable results for the best patient care...
2015: Postȩpy Higieny i Medycyny Doświadczalnej
Daljit Kaur, Ratti Ram Sharma, Neelam Marwaha
BACKGROUND AND OBJECTIVES: Different methods of platelet concentrate preparations leave behind certain number of residual leukocytes, accounting for most of the febrile nonhemolytic transfusion reactions, especially in multitransfused patients. Various inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 are generated during storage and have been implicated for these adverse effects. We have studied the levels of these cytokines and their correlation with leucocyte contents in platelet concentrates prepared by three different methods...
January 2015: Asian Journal of Transfusion Science
Jana Chovancová, Tomáš Bernard, Olga Stehlíková, David Šálek, Andrea Janíková, Jiří Mayer, Michael Doubek
BACKGROUND: Minimal residual disease (MRD) detection is an essential tool for therapy response assessment in a considerable number of hematooncologic disorders, including mantle cell lymphoma (MCL). Flow cytometry (FCM) ranks among the most effective approaches, which allows rapid sample processing and compete successfully with highly sensitive molecular methods like polymerase chain reaction. Because FCM is ordinarily applied to detect MRD in B-lineage diseases like chronic lymphocytic leukemia, a similar method could be used in MCL...
March 2015: Cytometry. Part B, Clinical Cytometry
Jana Chovancová, Tomáš Bernard, Olga Stehlíková, David Sálek, Andrea Janíková, Jiří Mayer, Michael Doubek
Backround: Minimal residual disease (MRD) detection is an essential tool for therapy response assessment in a considerable number of hematooncologic disorders including mantle cell lymphoma (MCL). Flow cytometry (FCM) ranks among the most effective approaches which allow rapid sample processing and compete successfully with highly sensitive molecular methods like polymerase chain reaction (PCR). Since FCM is ordinarily applied to detect MRD in B-lineage diseases like chronic lymphocytic leukemia (CLL), a similar method could be used in MCL...
November 28, 2014: Cytometry. Part B, Clinical Cytometry
Elvan Akin, Ulrich Krüger, Peter Braun, Erika Stroh, Ilse Janicke, Reza Rezwanian, Ibrahim Akin, Wolfgang H Schöls
BACKGROUND: Dyspnoe is a symptom with a huge differential diagnostic spectrum. According to patients hemodynamic, acute forms can be caused by myocardial infarction, pulmonary embolism, pulmonary edema and heart rhythm disturbances while chronic forms can be caused by restrictive myocardial and pericardial diseases, hematooncological diseases, orthopedic deformations and chronic pulmonary diseases. The platypnea-orthodeoxia syndrome with underlying interatrial connection is a rare cause and need a special diagnostic work-up...
September 2014: Wiener Medizinische Wochenschrift
Andrea Doescher, Eduard K Petershofen, Bernd Hertenstein, Doris Kraemer, Jochen Casper, Jörg-Peter Schmidt, Thomas H Müller
BACKGROUND: Mitochondrial (mt) DNA markers have been identified as potential targets for the quantification of endogenous and allogeneic platelets (PLTs) in the blood of individuals who received transfusions. Our goal was to develop a routine polymerase chain reaction (PCR) assay for ex vivo monitoring of PLT survival in patients after transfusion. STUDY DESIGN AND METHODS: Targets were selected for real-time (RT)-PCR of mt DNA based on the frequency distribution of nucleotide polymorphisms and assay sensitivity in vitro...
January 2015: Transfusion
P Flodr, P Latalova, M Tichy, Z Kubova, T Papajik, M Svachova, K Vrzalikova, L Radova, M Jarosova, P Murray
The basic principles of lymphoma classification(s) in general have been widely evolving in a course of decades of years wiht the use of contemporary resources and recent cutting edges in hematooncology on a clinical, morphological and molecular level bring new possibilities not only in improvements of diagnostic and prognostic algorithms and also bear new opportunities in so called targeted and tailored strategies of lymphoma therapy. The pathogenesis and biologic behavior of lymphoproliferations and even lymphomas should be studied in a context of lymphocytic and (neoplastic) lymphoid stage and chronologic development...
2014: Neoplasma
Ram Prakash Thirugnanasambandam, Magatha Sneha Latha, Aravind Moorthy, Lakshminarayanan Kannan, Venkataraman Paramasivam, Julius Xavier Scott
OBJECTIVES: The health care scenario in India is experiencing an increase in the number of children affected with cancer and the number of pediatric oncologists available to treat these children are few and the awareness of childhood cancer is decimally low. Hence, the purpose of this study was to determine the attitude of post-graduate students of general pediatrics towards childhood cancer and to assess their interest in pursuing pediatric oncology as a specialty in their carrier. MATERIALS AND METHODS: The study was conducted among 188 post-graduates hailing from various Medical colleges all over South India who were attending a 2 day workshop at Chennai...
January 2014: Indian Journal of Medical and Paediatric Oncology
Atul P Kulkarni, Jigeeshu V Divatia
BACKGROUND: The costs of healthcare are increasing. Intensive care poses largest burden on the hospital budget, even in developed countries. We attempted to find out the costs of intensive care in an Indian cancer hospital. MATERIALS AND METHODS: Cost data was prospectively collected for patient-related and non-patient-related activities in a mixed surgical, medical cancer ICU. Demographic data, source, reason, and length of ICU stay were recorded. Total per day costs, costs for patients admitted from wards and operating rooms, and effective cost per survivor (ECPS) were calculated...
September 2013: Indian Journal of Critical Care Medicine
L Kubiczková, M Dúcka, L Sedlaříková, F Kryukov, R Hájek, S Ševčíková
Multiple myeloma is the second most common hematooncological disease characterized by clonal proliferation of plasma cells and monoclonal immunoglobulin production. It is a heterogenous disease; however, dysregulation of cyclins D seems to be an early unifying pathogenic event in multiple myeloma. In almost all patients, there is increased expression level of at least one of the cyclins D. Nevertheless, the mechanism of this increase is unknown in many cases. Next to wellknown roles of cyclins D in the cell cycle, they have many other functions contributing to tumor cell progression...
2013: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
Mayra Gonçalves Menegueti, Lécio Rodrigues Ferreira, Magda Fabbri Isaac Silva, Anderson Soares da Silva, Fernando Bellissimo-Rodrigues
Worldwide aging of the human population has promoted an increase in the incidence of neoplasia, including hematological cancers, which render patients particularly vulnerable to invasive fungal infections. For this reason, air filtration in hematooncology units has been recommended. However, scarce literature has assessed the impact of microbiological air quality on the occurrence of fungal infections in this population. We performed an integrative review of studies in the MEDLINE database that were published between January 1980 and October 2012, using the following combinations of keywords: air × quality × HEPA, air × quality × hematology, and airborne fungal infections...
July 2013: Revista da Sociedade Brasileira de Medicina Tropical
Z Rácil, J Mayer, I Kocmanová, B Wagnerová, J Winterová, F Folber, M Lengerová, M Moulis, D Zácková, L Smardová, A Janíková, M Navrátil, D Dvoráková, J Vorlícek
BACKGROUND: Invasive aspergillosis (IA) is a leading invasive fungal infection in hematooncological patients. The aim of this study was to analyse the incidence, diagnostic procedures and treatment of IA in hematooncological department in large hospital in the Czech Republic. PATIENTS AND METHODS: A retrospective analysis of medical and laboratory records from patients hospitalised in our department with proven/probable IA between January 2000 and December 2006 was performed...
February 2008: Vnitr̆ní Lékar̆ství
P Szturz, J Kyclová, M Moulis, M Navrátil, Z Adam, J Vaníček, J Mayer
BACKGROUND: Spontaneous hepatic bleeding is a rare but potentially life-threatening complication of primary systemic amyloidosis. Although the liver is a common site of amyloid deposition, clinical presentation is usually mild or absent. CASE: We report a case of a female patient, who had been repeatedly surgically revised because of liver rupture and hemoperitoneum. Initially, the computed tomography finding was interpreted as liver hemangioma. However, based on liver biopsy, the diagnosis had to be changed to primary systemic amyloidosis, and the patient was referred to our hematooncology department...
2013: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
T Staudinger
Critically ill cancer patients on intensive units with hematological or oncological underlying diseases are a special situation: the underlying disease may be incurable, acute problems are often therapy associated and immunosuppression is regularly present. Due to evolving knowledge about special aspects of these patients and optimized supportive therapy, the prognosis has substantially improved during the last decades. General reluctance to admit cancer patients to an intensive care unit is therefore no longer justified...
April 2013: Medizinische Klinik, Intensivmedizin und Notfallmedizin
Anna Grenda, Michał Budzyński, Agata A Filip
MicroRNAs (miRNAs) are a group of small molecules, about twenty nucleotides in length. They are involved in the regulation of gene expression mainly at a posttranscriptional level. This function depends on their complementarity to the 3'UTR regions of mRNAs. MicroRNAs are essential for proper development and functioning of the organism. They are so important because of their participation in such processes as angiogenesis, apoptosis, cell cycle control and oncogenesis. Over thirty percent of human genes are controlled by miRNAs...
2013: Postȩpy Higieny i Medycyny Doświadczalnej
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