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https://www.readbyqxmd.com/read/28525945/the-protective-effect-of-luteolin-on-myocardial-ischemia-reperfusion-i-r-injury-through-tlr4-nf-%C3%AE%C2%BAb-nlrp3-inflammasome-pathway
#1
Xu Zhang, Qianming Du, Yan Yang, Jianing Wang, Shuai Dou, Chao Liu, Junguo Duan
The purpose of the present study was to investigate the effect of Luteolin(Lut) on myocardial ischemia reperfusion injury and explore the underlying mechanism. Myocardial ischemia reperfusion injury (I/R) model was induced with 30min of left anterior descending (LAD) occlusion followed by 24h of reperfusion. In vivo, the rats were randomly divided into 5 groups: (1)Sham, (2)I/R, (3)I/R+Lut(40mg/kg), (4)I/R+Lut(80mg/kg) and (5)I/R+Lut(160mg/kg). In vitro, the H9c2 cells were assigned to five groups: (1)control, (2)hypoxia-reoxygenation(H/R), (3)H/R+Lut(5μM), (4)H/R+Lut(10μM) and (5)H/R+Lut(20μM)...
May 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28521370/salvia-plebeia-extract-inhibits-xanthine-oxidase-activity-in-vitro-and-reduces-serum-uric-acid-in-an-animal-model-of-hyperuricemia
#2
Jin Kyu Kim, Woo Jung Kim, Jung Mi Hyun, Jong Suk Lee, Jin Gwan Kwon, Changon Seo, Myung-Jin Song, Chun Whan Choi, Seong Su Hong, Kyuhee Park, Pansoo Kim, Hachang Sung, Jin Koo Lee, Yongmun Choi
Hyperuricemia is a clinical condition characterized by an elevated level of serum uric acid and is a key risk factor for the development of gout and metabolic disorders. The existing urate-lowering therapies are often impractical for certain patient populations, providing a rationale to explore new agents with improved safety and efficacy. Here, we discovered that Salvia plebeia extract inhibited the enzyme activity of xanthine oxidase, which is a key enzyme generating uric acid in the liver. In an animal model of hyperuricemia, S...
May 18, 2017: Planta Medica
https://www.readbyqxmd.com/read/28513167/quercetin-luteolin-phloretin-and-morin-are-dietary-flavonoid-inhibitors-of-monocarboxylate-transporter-6
#3
Robert Spencer Jones, Mark Parker, Marilyn Emily Morris
Monocarboxylate transporter 6 (MCT6; SLC16A5) has been recognized for its role as a xenobiotic transporter, with characterized substrates probenecid, bumetanide, and nateglinide. To date, the impact of commonly ingested dietary compounds on MCT6 function has not been investigated and therefore, the objective of this study was to evaluate a variety of flavonoids for their potential MCT6-specific interactions. Flavonoids are a large group of polyphenolic phytochemicals found in commonly consumed plant-based products that have been recognized for their dietary health benefits...
May 17, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28508182/new-antimicrobial-flavonoids-and-chalcone-from-colutea-armata
#4
Farah Inamullah, Itrat Fatima, Sadia Khan, Mehdi Hassan Kazmi, Abdul Malik, Rasool Bakhsh Tareen, Tanveer Abbas
Colucins A (1) and B (2), new flavonoids and colucone (3), the new chalcone derivative, have been isolated from the CHCl3-soluble fraction of the whole plant of Colutea armata along with luteolin (4), luteolin 7-O-β-D-glucoside (5), isoliquiritigenin (6), trans-caffeic acid (7) and stigmasterol (8) reported for the first time from this species. Their structures were elucidated by spectroscopic techniques including MS and 2D-NMR spectroscopy. Compounds 1 and 2 showed significant antimicrobial activity against two Gram positive and three Gram negative bacterial strains while 3 was moderately active...
May 15, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28504280/metabolic-profile-and-underlying-improved-bio-activity-of-fructus-aurantii-immaturus-by-human-intestinal-bacteria
#5
Xing Yan Liu, Meng Lin Fan, Huai You Wang, Bo Yang Yu, Ji Hua Liu
Fructus aurantii immaturus (FAI) is the dried young fruit of Citrus aurantium L. or Citrus sinensis L. Osbeck. The purpose of this paper was to investigate the metabolic fate of FAI upon incubation with human intestinal bacteria, meanwhile to evaluate the antioxidant and anti-inflammatory activities of FAI and the transformed Fructus aurantii immaturus (TFAI). The water extract of FAI was anaerobically incubated with human intestinal bacterial suspensions for 48 h at 37 °C. Liquid chromatography-hybridised with quadrupole-time-of-flight mass spectrometry (LC-Q-TOF/MS) was applied to identify FAI metabolites...
May 15, 2017: Food & Function
https://www.readbyqxmd.com/read/28503053/pea-pisum-sativum-and-its-anticancer-activity
#6
REVIEW
Runchana Rungruangmaitree, Wannee Jiraungkoorskul
Pisum sativum (Family: Fabaceae), as known as green pea or garden pea, has long been important in diet due to its content of fiber, protein, starch, trace elements, and many phytochemical substances. It has been shown to possess antibacterial, antidiabetic, antifungal, anti-inflammatory, antihypercholesterolemia, and antioxidant activities and also shown anticancer property. Its nonnutritive biologically active components include alkaloids, flavonoids, glycosides, isoflavones, phenols, phytosterols, phytic acid, protease inhibitors, saponins, and tannins...
January 2017: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/28502822/anti-inflammatory-properties-of-the-stem-bark-from-the-herbal-drug-vitex-peduncularis-wall-ex-schauer-and-characterization-of-its-polyphenolic-profile
#7
Federico Ferreres, Sutsawat Duangsrisai, Nelson G M Gomes, Rungcharn Suksungworn, David M Pereira, Angel Gil-Izquierdo, Patrícia Valentão, Kiattawee Choowongkomon, Paula B Andrade
Vitex spp. have been reported as constituents of herbal preparations, namely Vitex peduncularis, commonly used in Asian countries. Unlike other species extensively investigated, reports on the biological activities and chemical profile of V. peduncularis are still scarce. In this work, the polyphenolic profile of V. peduncularis stem bark was unveiled, revealing a high content of apigenin and luteolin derivatives. More than 20 polyphenols were identified and quantitated for the first time, including C-rhamnosyl flavones infrequently reported...
May 11, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28502116/phenolic-composition-anti-inflammatory-antioxidant-and-antimicrobial-activities-of-alchemilla-mollis-buser-rothm
#8
Gökçe Şeker Karatoprak, Selen İlgün, Müberra Koşar
The current study was designed to evaluate the antioxidant, anti-inflammatory and antimicrobial activities of Alchemilla mollis (Buser) Rothm. (Rosaceae) aerial parts extracts. Chemical composition was analyzed by spectrophotometric and chromatographic (HPLC) techniques. The antioxidant properties assessed included, DPPH(●) and ABTS(●+) radical scavenging, β-carotene-linoleic acid co-oxidation assay. Antimicrobial activity was evaluated with disc diffusion and micro dilution method. In order to evaluate toxicity of the extracts with the sulforhodamine B (SRB) colorimetric assay L929 cell line (mouse fibroblast) was used...
May 14, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28498799/dietary-luteolin-attenuates-chronic-liver-injury-induced-by-mercuric-chloride-via-the-nrf2-nf-%C3%AE%C2%BAb-p53-signaling-pathway-in-rats
#9
Haili Zhang, Xiao Tan, Daqian Yang, Jingjing Lu, Biying Liu, Ruiqi Baiyun, Zhigang Zhang
Mercury exposure is a common cause of metal poisoning which is biotransformed to highly toxic metabolites thus eliciting biochemical alterations and oxidative stress. Luteolin, a phenolic compound found in many natural products, has multiple biological functions. Our study was aimed to explore the biological effects of luteolin in a liver injury model induced in rats by mercuric chloride (HgCl2). Criteria for injury included liver enzyme, glutathione and malondialdehyde levels, histopathology, TUNEL assay, hepatocyte viability and reactive oxygen species levels...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28498401/luteolin-induced-apoptosis-through-activation-of-endoplasmic-reticulum-stress-sensors-in-pheochromocytoma-cells
#10
Kisang Kwon, Young-Sook Kwon, Seung-Whan Kim, Kweon Yu, Kyung-Ho Lee, O-Yu Kwon
Luteolin [2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-chromenone] is an active flavonoid compound from Lonicera japonica (Caprifoliaceae). Luteolin inhibits tumor cell proliferation, inflammatory and oxidative stress better, when compared with other flavonoids. In the present study, it was demonstrated that luteolin induces typical apoptosis in PC12 cells (derived from a pheochromocytoma of the rat adrenal medulla) accompanied by DNA fragmentation and formation of apoptotic bodies. In addition, luteolin regulates expression of the endoplasmic reticulum (ER) chaperone binding immunoglobulin protein, activating ER stress sensors (eukaryotic initiation factor 2α phosphorylation and X‑box binding protein 1 mRNA splicing) and induced autophagy...
May 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28492713/flavonoids-and-anti-oxidant-activity-mediated-gastroprotective-action-of-leathery-murdah-terminalia-coriacea-roxb-wight-arn-leaf-methanolic-extract-in-rats
#11
Mohammed Safwan Ali Khan, Shaaz Nazan, Abdul Manan Mat Jais
BACKGROUND: Leathery Murdah, Terminalia coriacea (Roxb.) Wight & Arn. from family Combretaceae is used in Ayurveda and Siddha traditional systems of medicine to heal ulcers. OBJECTIVE: The present study was conducted to assess the gastroprotective effect and understand the fundamental mechanism of action of Leathery Murdah, Terminalia coriacea (Roxb.) Wight & Arn. Leaf Methanolic Extract. METHODS: The test extract was screened for anti-ulcer activity by Aspirin induced ulcerogenesis in pyloric ligation and ethanol induced gastric ulcers at three doses - 125, 250, and 500 mg/kg, p...
May 8, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28492621/leaf-parts-from-greek-artichoke-genotypes-as-a-good-source-of-bioactive-compounds-and-antioxidants
#12
Spyridon A Petropoulos, Carla Pereira, Lillian Barros, Isabel C F R Ferreira
Globe artichoke is an important vegetable in the Mediterranean diet. However, the marketable part of the plant constitutes a small portion of its total crop biomass and large amounts of waste are produced during its cultivation. In this study, the phenolic compound content and composition and the antioxidant activity of leaf parts [blades (SLB), petioles and midribs (SPM)] from various Greek artichoke genotypes were evaluated. The results showed significant variation in antioxidant activities and bioactive compound contents between the studied genotypes, with the leaf blades of most of the genotypes having a high content of flavonoids (mainly luteolin glycoside derivatives), which ranged between 49 and 78% of total phenolic compounds (TPC)...
May 11, 2017: Food & Function
https://www.readbyqxmd.com/read/28488389/chemical-profiling-and-assessment-of-antineurodegenerative-and-antioxidant-properties-of-veronica-teucrium-l-and-veronica-jacquinii-baumg
#13
Jelena Č Živković, João C M Barreira, Katarina P Šavikin, Ana Z Alimpić, Dejan S Stojković, Maria Inês Dias, Celestino Santos-Buelga, Sonja N Duletić-Laušević, Isabel C F R Ferreira
Neuroprotective potential of V. teucrium and V. jacquinii methanol extracts was analyzed. Chemical analysis of investigated extracts showed the presence of phenolic acid derivatives, flavonoids and one secoiridoid. The detected flavonoids derived from flavones (luteolin and isoscutellarein in V. jacquinii; apigenin, isoscutellarein and luteolin in V. teucrium) and flavonol (quercetin in V. jacquinii). Acteoside was the dominant compound in V. jacquinii, while plantamajoside and isoscutellarein 7-O-(6'''-O-acetyl)-β-allosyl (1'''→2''')-β-glucoside were the major phenolics in V...
May 10, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28488331/terminalia-ferdinandiana-exell-extracts-inhibit-the-growth-of-body-odour-forming-bacteria
#14
Kane McManus, Aiden Wood, Mitchell Henry Wright, Ben Matthews, Anthony Carlson Greene, Ian Edwin Cock
OBJECTIVE: T. ferdinandiana extracts are potent growth inhibitors of many bacterial pathogens. They may also inhibit the growth of malodour producing bacteria and thus be useful deodorant components, although this is yet to be tested. METHODS: T. ferdinandiana fruit and leaf solvent extracts were investigated by disc diffusion and liquid dilution MIC assays against the most significant bacterial contributors to axillary and plantar malodour formation. Toxicity was determined using the Artemia franciscana nauplii bioassay...
May 10, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28481281/the-functional-characterization-of-a-site-specific-apigenin-4-o-methyltransferase-synthesized-by-the-liverwort-species-plagiochasma-appendiculatum
#15
Hui Liu, Rui-Xue Xu, Shuai Gao, Ai-Xia Cheng
Apigenin, a widely distributed flavone, exhibits excellent antioxidant, anti-inflammatory, and antitumor properties. In addition, the methylation of apigenin is generally considered to result in better absorption and greatly increased bioavailability. Here, four putative Class II methyltransferase genes were identified from the transcriptome sequences generated from the liverwort species Plagiochasma appendiculatum. Each was heterologously expressed as a His-fusion protein in Escherichia coli and their methylation activity against apigenin was tested...
May 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28479197/anti-atherosclerotic-activities-of-flavonoids-from-the-flowers-of-helichrysum-arenarium-l-moench-through-the-pathway-of-anti-inflammation
#16
Zhonghua Mao, Chunli Gan, Jiuxin Zhu, Nan Ma, Lijun Wu, Libo Wang, Xiaobo Wang
We have successfully established AS model using thoracic aortas vascular ring which evaluated by the morphological changes of blood vessels, the proliferation of VSMC, and the expression of inflammation factors VEGF, CRP, JNK2 and p38. This AS model has the advantages of low cost, convenient and short period of established time. Moreover, we investigated the anti-AS activities of 7 flavonoids Narirutin (1), Naringin (2), Eriodictyol (3), Luteolin (4), Galuteolin (5), Astragalin (6), Kaempferol (7) from flowers of Helichrysum arenarium L...
April 27, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28466032/identification-of-new-potent-inhibitors-of-dengue-virus-ns3-protease-from-traditional-chinese-medicine-database
#17
Vivek Dhar Dwivedi, Indra Prasad Tripathi, Shiv Bharadwaj, Aman Chandra Kaushik, Sarad Kumar Mishra
Dengue virus (DENV) has emerged as an increasing fitness problem in the world for which no specialized drug is available. The non-structural protein NS3 protease of DENV has already been recognized as a potential therapeutic target for the discovery and development of novel antiviral agents against DENV infections. In this study, we employed the virtual screening technique to explore the potent inhibitors of DENV NS2B/NS3pro from Traditional Chinese Medicine (TCM) database. Total 200 inhibitors from TCM against DENV NS3pro were screened and only five TCM compounds like eriodictyol 7-O-glucuronide, luteolin 8-C-beta-glucopyranoside, (-)-epicatechin-3-O-gallate, 6-O-trans-p-coumaroylgeniposide and luteolin-7-O-glucoside were selected for further analysis which showed binding energies, -7...
September 2016: Virusdisease
https://www.readbyqxmd.com/read/28465374/regulation-of-delta-opioid-receptor-mediated-signaling-and-antinociception-in-peripheral-sensory-neurons-by-arachidonic-acid-dependent-12-15-lipoxygenase-metabolites
#18
Laura C Sullivan, Teresa A Chavera, Xiaoli Gao, Miryam M Pando, Kelly A Berg
The function of delta opioid receptors (DOR) expressed by peripheral pain-sensing neurons (nociceptors) is regulated by both cyclooxygenase (COX)- and lipoxygenase (LOX)-dependent arachidonic acid (AA) metabolites (Sullivan et al., 2015). Whereas COX metabolites enhance responsiveness, LOX metabolites elicit a refractory, non-signaling state of the DOR receptor system for antinociceptive signaling. In this study, using high performance liquid chromatography tandem mass spectrometry analyses, we have found that the 12/15-LOX metabolites, 12-hydroxyeicosatetraenoic acid (HETE) and 15-HETE, were elevated following treatment of adult rat primary sensory neuron cultures with AA...
May 2, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28465252/antioxidant-and-anti-inflammatory-activities-of-the-major-phenolics-from-zygophyllum-simplex-l
#19
Hossam M Abdallah, Ahmed Esmat
ETHNOPHARMACOLOGICAL RELEVANCE: Zygophyllum simplex L. is a halophyte plant that follows Zygophyllaceae. The plant is growing in arid and semiarid regions. It has been used traditionally in Arabic region to treat gout, asthma and inflammation. AIM OF STUDY: Although ant-inflammatory activity has been reported for this plant, this study aimed to isolate and identify the major constituents of Zygophyllum simplex L., as well as assessing their antioxidant and anti-inflammatory activities in-vitro...
April 29, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28464859/lyophilized-aqueous-extracts-of-mori-fructus-and-mori-ramulus-protect-mesenchymal-stem-cells-from-%C3%A2-oh-treated-damage-bioassay-and-antioxidant-mechanism
#20
Qian Jiang, Xican Li, Yage Tian, Qiaoqi Lin, Hong Xie, Wenbiao Lu, Yuguang Chi, Dongfeng Chen
BACKGROUND: Mori Fructus and Mori Ramulus are two traditional Chinese herbal medicines from mulberries. The present work explores their beneficial effects on •OH-treated mesenchymal stem cells (MSCs) and discusses possible mechanisms. METHODS: Lyophilized aqueous extracts of Mori Fructus (LAMF) and Mori Ramulus (LAMR) were prepared and analyzed using HPLC. LAMF and LAMR (along with morin) were further investigated for their effects on •OH-treated MSCs using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl (MTT) assay...
May 2, 2017: BMC Complementary and Alternative Medicine
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