keyword
MENU ▼
Read by QxMD icon Read
search

Luteoline

keyword
https://www.readbyqxmd.com/read/28433594/favouring-no-over-h2o2-production-will-increase-pb-tolerance-in-prosopis-farcta-via-altered-primary-metabolism
#1
Somaieh Zafari, Mohsen Sharifi, Luis A J Mur, Najmeh Ahmadian Chashmi
Reactive oxygen species (ROS) and nitric oxide (NO) are known in triggering defense functions to detoxify heavy metal stresses. To investigate the relevance of ROS production, Pb treatment (400µM) alone and in combination with 400µM sodium ascorbate (Asc: as H2O2 scavenger) were given to hydroponically grown Prosopis farcta seedlings over a time course of 72h. Data presented here indicate that, the low extent of H2O2 due to scavenging by ascorbate, together with high level of NO improved Pb+Asc- treated Prosopis growth...
April 20, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28429944/biotechnological-production-of-dimethoxyflavonoids-using-a-fusion-flavonoid-o-methyltransferase-possessing-both-3-and-7-o-methyltransferase-activities
#2
Danbi Lee, Hye Lin Park, Sang-Won Lee, Seong Hee Bhoo, Man-Ho Cho
Although they are less abundant in nature, methoxyflavonoids have distinct physicochemical and pharmacological properties compared to common nonmethylated flavonoids. Thus, enzymatic conversion and biotransformation using genetically engineered microorganisms of flavonoids have been attempted for the efficient production of methoxyflavonoids. Because of their regiospecificity, more than two flavonoid O-methyltransferases (FOMTs) and enzyme reactions are required to biosynthesize di(or poly)-methoxyflavonoids...
April 21, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28416455/protection-from-cr-vi-induced-malignant-cell-transformation-and-tumorigenesis-of-cr-vi-transformed-cells-by-luteolin-through-nrf2-signaling
#3
Young-Ok Son, Poyil Pratheeshkumar, Yuting Wang, Donghern Kim, Zhuo Zhang, Xianglin Shi
Cr(VI) is a well known environmental carcinogen, but its mechanism of action and the measures required to mitigate its effects remain to be investigated. Our previous studies showed that exposure of human bronchial epithelial (BEAS-2B) cells to Cr(VI) caused malignant transformation, that these transformed cells progressed through tumorigenesis, and that luteolin, a natural compound, inhibited both of these processes. The present study investigates the underlying mechanisms by which luteolin protects cells against Cr(VI)-induced transformation and tumorigenesis...
April 14, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28415707/luteolin-reduces-inflammation-in-staphylococcus-aureus-induced-mastitis-by-inhibiting-nf-kb-activation-and-mmps-expression
#4
Ying-Fang Guo, Nian-Nian Xu, Weijing Sun, Yifan Zhao, Cheng-Ye Li, Meng-Yao Guo
Mastitis is a serious and prevalent disease caused by infection by pathogens such as Staphylococcus aureus. We evaluated the anti-inflammatory effects and mechanism of luteolin, a natural flavonoid with a wide range of pharmacological activities, in a mouse model of S. aureus mastitis. We also treated cultured mouse mammary epithelial cells (mMECs) with S. aureus and luteolin. Histopathological changes were examined by H&E staining and the levels of inflammatory cytokine proteins were analyzed using ELISAs...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28411511/elevated-co2-and-salinity-are-responsible-for-phenolics-enrichment-in-two-differently-pigmented-lettuces
#5
Cristina Sgherri, Usue Pérez-López, Francesco Micaelli, Jon Miranda-Apodaca, Amaia Mena-Petite, Alberto Muñoz-Rueda, Mike Frank Quartacci
Both salt stress and high CO2 level, besides influencing secondary metabolism, can affect oxidative status of plants mainly acting in an opposite way with salinity provoking oxidative stress and elevated CO2 alleviating it. The aim of the present work was to study the changes in the composition of phenolic acids and flavonoids as well as in the antioxidant activity in two differently pigmented lettuce cvs (green or red leaf) when submitted to salinity (200 mM NaCl) or elevated CO2 (700 ppm) or to their combination in order to evaluate how a future global change can affect lettuce quality...
April 7, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28411462/flavone-polyphenols-dominate-in-thymus-schimperi-ronniger-lc-esi-ms-ms-characterization-and-study-of-anti-proliferative-effects-of-plant-extract-on-ags-and-hepg2-cancer-cells
#6
Kebede Taye Desta, Gon Sup Kim, A M Abd El-Aty, Suchismita Raha, Man-Bae Kim, Ji Hoon Jeong, Mohamad Warda, Ahmet Hacımüftüoğlu, Ho-Chul Shin, Jae-Han Shim, Sung Chul Shin
Thymus schimperi is a highly localized and a rare plant endemic to Ethiopia. An optimized and validated high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS) method was applied to characterize 23 polyphenolic compounds found in ethyl acetate extracts of the plant. From those, flavones dominated and luteolin was the major component contributing 21.83% of the total composition (or 46.05±0.59g/kg of fresh sample weight). Validation data showed a determination coefficient (R(2))≥0...
March 31, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28408221/identification-and-structure-activity-relationship-of-novel-flavone-derivatives-that-inhibit-the-production-of-nitric-oxide-and-pge2-in-lps-induced-raw-264-7-cells
#7
Ji-Young An, Hwi-Ho Lee, Ji-Sun Shin, Hyung-Seok Yoo, Jong Seon Park, Seung Hwan Son, Sang Won Kim, Jihyun Yu, Jun Lee, Kyung-Tae Lee, Nam-Jung Kim
In an effort to identify novel anti-inflammatory compounds, a series of flavone derivatives were synthesized and biologically evaluated for their inhibitory effects on the production of nitric oxide (NO) and prostaglandin E2 (PGE2), representative pro-inflammatory mediators, in LPS-induced RAW 264.7 cells. Their structure-activity relationship was also investigated. In particular, we found that compound 3g displayed more potent inhibitory activities on PGE2 production, similar inhibitory activities on NO production and less weak cytotoxicity than luteolin, a natural flavone known as a potent anti-inflammatory agent...
March 28, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28407920/preharvest-application-of-oxalic-acid-improves-quality-and-phytochemical-content-of-artichoke-cynara-scolymus-l-at-harvest-and-during-storage
#8
Alejandra Martínez-Esplá, María Emma García-Pastor, Pedro Javier Zapata, Fabián Guillén, María Serrano, Daniel Valero, Amadeo Gironés-Vilaplana
In this study the effect of oxalic acid (OA) treatment of artichoke plants (Cynara scolymus L.) on head artichoke development and on artichokes quality parameters (weight loss, firmness, and color), respiration rate, antioxidant activity and phenolics (measured by Folin Ciocalteu and HPLC-DAD-ESI/MS(n)) at harvest and during storage for 21days at 2°C was evaluated. OA treatment increased the percentage of the first class artichokes although no significant effect was found in artichoke developmental process...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28405852/chlorinated-flavonoids-modulate-the-inflammatory-process-in-human-blood
#9
Carina Proença, Daniela Ribeiro, Tânia Soares, Sara M Tomé, Artur M S Silva, José L F C Lima, Eduarda Fernandes, Marisa Freitas
Flavonoids are known to react with neutrophil-generated hypochlorous acid (HOCl) at inflammation loci to form stable mono- and dichlorinated products. Some of these products have been shown to retain or even enhance their inflammatory potential, but further information is required in a broader approach to inflammatory mechanisms. In that sense, we performed an integrated evaluation on the anti-inflammatory potential of a panel of novel chlorinated flavonoids and their parent compounds, in several steps of the complex inflammatory cascade, namely, in the activity of cyclooxygenase (COX)-1 and COX-2, and in the production of cytokines [interleukin (IL)-6, IL-1β, tumor necrosis factor (TNF)], and the chemokine, IL-8, as well as in the production of reactive species, using human whole blood as a representative in vitro model, establishing, whenever possible, a structure-activity relationship...
April 13, 2017: Inflammation
https://www.readbyqxmd.com/read/28404689/methoxyluteolin-inhibits-neuropeptide-stimulated-tnf-cxcl8-and-vegf-release-via-mtor-activation-from-human-mast-cells
#10
Arti B Patel, Theoharis C Theoharides
Mast cells (MC) are critical for allergic reactions, but are also important in inflammatory processes. Stimulation by neuropeptides, such as substance P (SP) and neurotensin (NT) leads to release of pre-formed molecules stored in numerous MC secretory granules and newly-synthesized pro-inflammatory mediators, including tumor necrosis factor (TNF), interleukin 8 (CXCL8) and vascular endothelial growth factor (VEGF). Here, we investigate the role of mammalian target of rapamycin (mTOR) signaling in the stimulation of cultured human LAD2 MC by NT or SP, and the inhibitory effect of the natural flavonoids 3',4',5,7-tetrahydroxyflavone (luteolin) and its novel structural analog 3 ',4',5,7-tetramethoxyluteolin (methoxyluteolin)...
April 12, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28393257/luteolin-induces-apoptosis-by-ros-er-stress-and-mitochondrial-dysfunction-in-gliomablastoma
#11
Qiang Wang, Handong Wang, Yue Jia, Hao Pan, Hui Ding
OBJECTIVE: Luteolin, a common dietary flavonoid, induces apoptosis of many types of cancer cells. However, its role in glioblastoma and the potential mechanisms remain unknown. In this research, we studied the molecular mechanisms of the anti-cancer effect of luteolin in glioblastoma cancer cell lines. METHODS: Both U251MG and U87MG human glioblastoma cell lines were tested. Cell growth was assessed by the cell counting kit-8. Cell apoptosis was detected with flow cytometry and caspase-3 immunofluorescence staining...
April 9, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28391045/luteolin-inhibits-colorectal-cancer-cell-epithelial-to-mesenchymal-transition-by-suppressing-creb1-expression-revealed-by-comparative-proteomics-study
#12
Yuan Liu, Tingyuan Lang, Bingwei Jin, Feng Chen, Yi Zhang, Roger W Beuerman, Lei Zhou, Zhiqi Zhang
The cyclic AMP (cAMP) response element binding protein 1 (CREB1) is a promising target for cancer therapy. Here, we report that luteolin, a natural product, inhibits the expression of CREB1 at the transcriptional level and blocks epithelial-to-mesenchymal transition (EMT) of colorectal cancer cells. Treatment of colorectal cancer cells with luteolin induced mesenchymal-to-epithelial transition, reduced the expressions of mesenchymal markers and inhibited cell mobility in vitro. Through comparison of the proteomic profile of HCT-116 cells with and without luteolin treatment, we identified 366 differentially expressed proteins...
April 5, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28389141/luteolin-restricts-dengue-virus-replication-through-inhibition-of-the-proprotein-convertase-furin
#13
Minhua Peng, Satoru Watanabe, Kitti Wing Ki Chan, Qiuyan He, Ya Zhao, Zhongde Zhang, Xiaoping Lai, Dahai Luo, Subhash G Vasudevan, Geng Li
The increasing prevalence of dengue fever in the Indian sub-continent and Southern China is a major public health concern. There is currently an approved tetravalent vaccine available in a handful of countries for protection from dengue infection, but its efficacy against dengue virus (DENV) serotype 2 is not ideal and its overall performance in children under 9 years of age is poor. In many of the dengue afflicted countries-traditional medicine is widely used as a panacea for illnesses and here we describe the systematic evaluation of a natural product, luteolin, originating from the "heat clearing" class of herbs...
April 4, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28377982/mechanistic-insight-into-the-effects-of-aryl-hydrocarbon-receptor-activation-on-osteogenic-differentiation
#14
Chawon Yun, Joseph A Weiner, Danielle S Chun, Jonghwa Yun, Ralph W Cook, Michael S Schallmo, Abhishek S Kannan, Sean M Mitchell, Ryan D Freshman, Christian Park, Wellington K Hsu, Erin L Hsu
While inhibition of bone healing and increased rates of pseudarthrosis are known adverse outcomes associated with cigarette smoking, the underlying mechanisms by which this occurs are not well understood. Recent work has implicated the Aryl Hydrocarbon Receptor (Ahr) as one mediator of the anti-osteogenic effects of cigarette smoke (CS), which contains numerous toxic ligands for the Ahr. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) is a high-affinity Ahr ligand frequently used to evaluate Ahr pathway activation...
June 2017: Bone Reports
https://www.readbyqxmd.com/read/28377794/antioxidant-cytotoxic-and-toxic-activities-of-propolis-from-two-native-bees-in-brazil-scaptotrigona-depilis-and-melipona-quadrifasciata-anthidioides
#15
Thaliny Bonamigo, Jaqueline Ferreira Campos, Tamaeh Monteiro Alfredo, José Benedito Perrella Balestieri, Claudia Andrea Lima Cardoso, Edgar Julian Paredes-Gamero, Kely de Picoli Souza, Edson Lucas Dos Santos
Propolis is a natural mixture of compounds produced by various bee species, including stingless bees. This compound has been shown to exhibit antioxidant, antiproliferative, and antitumor activities. The present study aimed to determine the chemical constituents as well as the antioxidant, cytotoxic, and toxic activities of ethanol extracts of propolis obtained from the stingless bees Scaptotrigona depilis and Melipona quadrifasciata anthidioides, which are found in Brazil. Phytosterols, terpenes, phenolic compounds, and tocopherol were identified in the ethanol extracts of propolis (EEPs) in different concentrations...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28375095/the-study-of-polyphenolic-compounds-profile-of-some-rosmarinus-officinalis-l-extracts
#16
Neli-Kinga Olah, Gyongyi Osser, Ramona Flavia Câmpean, Flavia Roxana Furtuna, Daniela Benedec, Lorena Filip, Oana Raita, Daniela Hanganu
The purpose of this study was to compare the polyphenol profile of different Rosemary (Rosmarinus officinalis) extracts obtained from dry and fresh herb and the evaluation of their antioxidant effect. There were studied the polyphenols from hydroalcoholic extracts (1:5- dry plant:solvent) obtained from fresh respectively dry plant and the gemmotherapic extract obtained from fresh plant (1:20- dry plant: solvent). The polyphenol profile was evaluated by UV-Vis spectrophotometry, TLC and HPLC. The total polyphenol respectively flavonoids content were determined by UV-V is spectrophotometry...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28373891/simultaneous-determination-and-pharmacokinetic-study-of-quercetin-luteolin-and-apigenin-in-rat-plasma-after-oral-administration-of-matricaria-chamomilla-l-extract-by-hplc-uv
#17
Xiaoxv Dong, Wei Lan, Xingbin Yin, Chunjing Yang, Wenping Wang, Jian Ni
A simple and sensitive HPLC-UV method has been developed for the simultaneous determination of quercetin, luteolin, and apigenin in rat plasma after oral administration of Matricaria chamomilla L. extract. The flow rate was set at 1.0 ml/min and the detection wavelength was kept at 350 nm. The calibration curves were linear in the range of 0.11-11.36 μg/ml for quercetin, 0.11-11.20 μg/ml for luteolin, and 0.11-10.60 μg/ml for apigenin, respectively. The intraday and interday precisions (RSD) were less than 8...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28372166/octadecylimidazolium-ionic-liquid-modified-magnetic-materials-preparation-adsorption-evaluation-and-their-excellent-application-for-honey-and-cinnamon
#18
Houmei Liu, Zhan Li, Makoto Takafuji, Hirotaka Ihara, Hongdeng Qiu
A novel and versatile adsorbent based on 1-octadecylimidazolium ionic liquid modified magnetic nanoparticles (Fe3O4@SiO2@ImC18) possessing of both magnetic property and excellent adsorption ability was successfully synthesized. Twelve compounds from four kinds of substances (alkylbenzenes, PAHs, flavonoids and organic acids) were chosen as probe molecules to evaluate adsorption properties of the new adsorbent. A series of adsorption experiments were conducted and results indicated both synergism and competition effects were existed and multiple interactions took place during adsorption process...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28372151/quantification-of-phytoprostanes-bioactive-oxylipins-and-phenolic-compounds-of-passiflora-edulis-sims-shell-using-uhplc-qqq-ms-ms-and-lc-it-dad-ms-ms
#19
Sonia Medina, Jacinta Collado-González, Federico Ferreres, Julián Londoño-Londoño, Claudio Jiménez-Cartagena, Alexandre Guy, Thierry Durand, Jean-Marie Galano, Angel Gil-Izquierdo
The genus Passiflora, comprising about 500 species, is the largest in the Passion flower family. Passiflora edulis Sims f. edulis (gulupa) is one of the most important fruits cultivated in Colombia. In recent years and due to its organoleptic and bioactive properties, its exports have significantly increased. In this work, six new bioactive oxylipins -phytoprostanes - were detected in gulupa shell by a UHPLC-QqQ-MS/MS method: F1t-phytoprostanes and D1t-phytoprostanes were the predominant and minor classes, respectively...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28362855/inhibition-of-ano1-by-luteolin-and-its-cytotoxicity-in-human-prostate-cancer-pc-3-cells
#20
Yohan Seo, Kunhi Ryu, Jinhong Park, Dong-Kyu Jeon, Sungwoo Jo, Ho K Lee, Wan Namkung
Anoctamin 1 (ANO1), a calcium-activated chloride channel, is highly amplified in prostate cancer, the most common form of cancer and leading causes of cancer death in men, and downregulation of ANO1 expression or its functional activity is known to inhibit cell proliferation, migration and invasion in prostate cancer cells. Here, we performed a cell-based screening for the identification of ANO1 inhibitors as potential anticancer therapeutic agents for prostate cancer. Screening of ~300 selected bioactive natural products revealed that luteolin is a novel potent inhibitor of ANO1...
2017: PloS One
keyword
keyword
101663
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"