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Yu I Chergeshtov, V N Tsarev, A G Volkov, A S Nosik, N Zh Dikopova, D A Malanchuk
As a result of cliniko-microbiological research the data testifying to substantial improvement of efficiency of antimicrobictherape at inclusion in a complex of medical actions at alveolitis and the limited osteomyelitis of a jow ozone therapy in a combination with a light-emettinf diode irradiation of the hole extracted teeth red ( 630 nanometers) are obtained by light.
2016: Stomatologii︠a︡
A Zh Fursova, N V Chubar', M S Tarasov, I F Saifullina, G G Pustovaya
AIM: to describe baseline functional and anatomical parameters of the macular region and how they change under ranibizumab therapy depending on the type of diabetic macular edema (DME) determined with optical coherence tomography (OCT). MATERIAL AND METHODS: The study included 100 patients (100 eyes) with diabetes mellitus and DME (38 men and 62 women) aged 61.9±5.6 years with the mean disease duration of 8.48 years. Basing on OCT findings, 4 groups (25 patients each) were formed: sponge-like DME, cystoid DME, DME with serous neuroepithelium detachment (NED), and mixed DME (cystoid DME and serous NED)...
July 2016: Vestnik Oftalmologii
N V Lobanova, L V Shishkina, M V Ryzhova, G L Kobyakov, R V Sycheva, S A Burov, A V Luk'yanov, Zh R Omarova
UNLABELLED: Glioblastoma is the most common primary malignant glial tumor of the brain in adult patients. AIM: to define the prognostic value of isocitrate dehydrogenase-1 (IDH-1) mutation and methylguanine-DNA methyltransferase (MGMT) methylation status in patients with glioblastoma (GB) and to analyze the impact of clinical data (gender, age, and tumor site), histological variants of the tumor structure, and time to development of recurrences on the course of the disease...
July 2016: Arkhiv Patologii
A V Razygraev, K I Taborskaya, M A Petrosyan, Zh N Tumasova
Earlier it has been shown that extracellular glutathione peroxidase (GPx3) from human plasma is able to use cysteine (Cys-SH) instead of glutathione (GSH) as a thiol substrate. In the present study, the ability of rat plasma to utilize not only GSH, but also Cys-SH and homocysteine (Hcy-SH), in the thiol peroxidase reaction has been confirmed. The molar ratio between thiol and H2O2 in the catalyzed reaction was 2:1. The specific activity increased with fractionation of proteins. At a fixed thiol concentration of 0...
May 2016: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
A G Polipanov, Zh A Mamasaidov, Yu N Geleskhanova, N B Cheskidova, T A Romanova, A S Dzhumagulova
AIM: To estimate the possibility of predicting the presence and severity of coronary atherosclerosis from arterial stiffness characteristics and augmentation index (AIx) in patients with essential hypertension (EH) obtained under outpatient conditions. MATERIALS AND METHODS: The general clinical examination of 15 patients aged 30-70 yr with EH was supplemented by measuring blood glucose and creatinine levels, the lipid status (LWLP, HDLP, TG), duplex scanning of carotid arteries, and evaluation of arterial stiffness by pulsed wave contour analysis...
2016: Klinicheskaia Meditsina
D Z Albegova, O V Kamkina, S I Pavlova, Zh K Albegova, O S Laptev, I G Kozlov
We studied the effect of modified bioflavonoid and reference drug quercetin dihydrate on proliferation of mononuclears triggered by T- and B-cell mitogens. Lymphocytes were in vivo pretreated with the examined agents followed by their explantation and in vitro activation with T- and B-cell mitogens in cell culture. Intraperitoneal injection of modified bioflavonoid and quercetin dihydrate produced a dose-dependent inhibition of proliferation of the in vitroactivated splenocytes; modified bioflavonoid demonstrated higher antiproliferative activity...
July 2016: Bulletin of Experimental Biology and Medicine
M L Perepechaeva, N G Kolosova, N A Stefanova, A Zh Fursova, A Y Grishanova
Age-related macular degeneration (AMD) is a complex multifactorial disease of the elderly, with unclear pathogenesis; AMD is the leading cause of blindness. One of the destructive processes in AMD is oxidative stress, which leads to an imbalance in the processes responsible for production and detoxification of reactive oxygen species. The aryl hydrocarbon receptor (AhR) signaling pathway can participate in the development of oxidative stress, but the main regulator of antioxidant defense is nuclear factor, erythroid derived 2 (Nrf2)...
August 2016: Experimental and Molecular Pathology
S V Gritsaev, I I Kostroma, I M Zapreeva, A V Shmidt, S A Tiranova, V A Balashova, I S Martynkevich, Zh V Chubukina, N Yu Semenova, A V Chechetkin
Secondary myeloid neoplasia may be a complication of intensive cytostatic therapy. The most common types of secondary neoplasias are acute myeloid leukemia and myelodysplastic syndrome. The development of secondary atypical chronic myeloid leukemia (aCML) is an extremely rare phenomenon. The paper describes transformation of secondary myelodysplastic syndrome to aCML 6 months after its diagnosis. The development of aCML was accompanied by additional chromosomal aberration as monosomy of chromosome 17. No mutations in the JAK2, MPL, and CalR genes were detected...
2016: Terapevticheskiĭ Arkhiv
I I Kostroma, S V Gritsaev, Zh Yu Sidorova, S A Tiranova, S P Svitina, Yu S Drizhun, Zh V Chubukina, I S Martynkevich, S I Kapustin, S S Bessmel'tsev
AIM: to investigate the methylation status of the SOX7 and p15NK4b genes and Wnt signaling pathway antagonists in patients with acute myeloid leukemia (AML) in order to assess the association of the rate of aberrant methylation (AM) with the morphological variant and pattern of chromosomal aberrations, as well as the impact of the methylation status on survival. SUBJECTS AND METHODS: The data of 57 AML patients aged 20 to 79 years were analyzed. The methylation status of the genes was studied by methylation-specific polymerase chain reaction...
2016: Terapevticheskiĭ Arkhiv
A Maksimova, A M Glushakova, A V Kachalkin, I Yu Chernov, S N Panteleeva, Zh I Reznikova
Yeast abundance and species diversity in the colonies of Formica aquilonia ants in birch-pine forbs forest, Novosibirsk oblast, Russia, was studied. The average yeast number in the anthill material was 10³-10⁴CFU/g, reaching 10⁵ CFU/g in the hatching chambers. Typical litter species (Trichosporon monilfiforme and Cystofilobasidium capitatum) were predominant in soil and litter around the anthills. Apart from these species, ascomycete species of the family Debaryomycetaceae, Debaryomyces hansenii and Schwanniomyces vanrijiae, were predominant in the anthill material...
January 2016: Mikrobiologiia
T S Ramazanov, Zh A Moldabekov, M T Gabdullin
In this paper, the multipole expansion method is used to determine effective interaction potentials between particles in both classical dusty plasma and dense quantum plasma. In particular, formulas for interactions of dipole-dipole and charge-dipole pairs in a classical nondegenerate plasma as well as in degenerate quantum and semiclassical plasmas were derived. The potentials describe interactions between atoms, atoms and charged particles, dust particles in the complex plasma, atoms and electrons in the degenerate plasma, and metals...
May 2016: Physical Review. E
S V Villeval'de, Zh D Kobalava, A E Solov'eva, V S Moiseev
AIM: To study the incidence, pattern, and predictive factors of concurrent kidney and liver dysfunctions in patients with decompensated heart failure (HF). SUBJECTS AND METHODS: The kidney and liver function indicators were estimated in 322 patients aged 69.5±10.6 years with decompensated HF (hypertension in 87%, myocardial infarction in 57%, atrial fibrillation in 65%, chronic kidney disease in 39%, type 2 diabetes in 42%, a left ventricular ejection fraction (EF) of 38±13%, EF <35% 39%, NYHA Functional Class IV in 56%)...
2016: Terapevticheskiĭ Arkhiv
S M Knobel-Graves, J C Brooks, B J Johnson, J D Starkey, J L Beckett, J M Hodgen, J P Hutcheson, M N Streeter, C L Thomas, R J Rathmann, A J Garmyn, M F Miller
Vitamin D (D3) supplementation may be used to increase tenderness in beef from cattle fed zilpaterol hydrochloride (ZH). The study was arranged as a 2 × 2 factorial with fixed effects of ZH (no ZH or ZH fed at 8.3 mg/kg DM for 20 d with a 3-d withdrawal) and D3 (no D3 or 500,000 IU D3·steer·d for 10 d prior to harvest). Cattle ( = 466) were harvested in 2 blocks on the basis of BW with subsequent collection of carcass data. Full loins and inside rounds ( = 144 of each subprimal) were collected for fabrication of 5 steaks from the longissimus lumborum (LL), gluteus medius (GM), and semimembranosus (SM), which were aged for 7, 14, 21, 28, or 35 d...
June 2016: Journal of Animal Science
Valentihna N Kislitskaya, Zhandos D Kenzhin, Berikbay Zh Kultanov, Raushan S Dosmagambetova, Anar A Turmuhambetova
AIM: Objective of the study was to evaluate the state of the main indicators of antioxidant status and enzymes of purine metabolism in the germ cells of men living in the zone of ecological catastrophe Aral Sea region. METHODS: The criterion for inclusion is the stay of an adult in the Aral Sea area is not less than 5 years, employment in occupations with no more than 2 hazard class. Determination of the activity of adenosine deaminase (ADA) was conducted in semen by the method of Nemechek et al...
September 15, 2015: Open Access Macedonian Journal of Medical Sciences
Yasminur G Turdybekova, Raushan S Dosmagambetova, Symbat U Zhanabayeva, Gena V Bublik, Alik B Kubayev, Zhanbolat G Ibraibekov, Irina L Kopobayeva, Berikbay Zh Kultanov
In order to assess women's reproductive health in the Kyzylorda region (the Aral Sea) of Kazakhstan, 1406 women were involved in an integrated clinical-functional and laboratory examination, given regional and environmental ecological factors. The high level of endocrine gynecological pathology is indicated in the examined women. In both examined zones, there is a late menarche over 16 years old, which is 39%. It is indicated a trend towards younger age of menopause onset. Inflammatory diseases of the female genital organs affect a third of the examined women...
September 15, 2015: Open Access Macedonian Journal of Medical Sciences
A V Lovinskaya, S Zh Kolumbayeva, S K Abilev, O L Kolomiets
There was performed an assessment of genotoxic effects of rocket fuel component--unsymmetrical dimethylhydrazine (UDMH, heptyl)--on forming germ cells of male mice. Immunocytochemically there was studied the structure of meiotic nuclei at different times after the intraperitoneal administration of UDMH to male mice. There were revealed following types of disturbances of the structure of synaptonemal complexes (SCs) of meiotic chromosomes: single and multiple fragments of SCs associations of autosomes with a sex bivalent, atypical structure of the SCs with a frequency higher than the reference level...
2016: Gigiena i Sanitariia
L A Stankevich, K M Sonkin, N V Shemyakina, Zh V Nagornova, J G Khomenko, D S Perets, A V Koval
The article presents the results of classification of EEG patterns registered during imagined rhytmic movements of the fingers of the right hand (little, thumb, index, middle fingers) in 8 healthy subjects. The subjects imagined finger movements in a given rhythm; no external stimuli were used. A two-level committee of classifiers was developed for decoding: the first level included support vector machines and artificial neural networks; the second level included artificial neural network used for generalizing...
January 2016: Fiziologiia Cheloveka
Ekaterina Vachkova, D Bosnakovski, P Yonkova, N Grigorova, Zh Ivanova, P Todorov, G Penchev, A Milanova, G Simeonova, S Stanilova, I Penchev Georgiev
Rabbits are considered as appropriate animal models to study some obesity-associated abnormalities because of the similarity of their blood lipid profile and metabolism to humans. The current study was focused on comparison of adipose differentiation ability in rabbit adipose-derived stem cells (ADSC) in vitro. Subcutaneous and visceral stromal vascular fractions (SVF) were isolated from three 28-d-old New Zealand rabbits by collagenase digestion. Supernatants from both isolates were collected 24 h after the initial plating...
September 2016: In Vitro Cellular & Developmental Biology. Animal
E B Kasymova, O A Bashkina, Kh M Galimzyanov, K Zh Engibaryan, L P Rodina, L S Chanpalova, A L Kovalenko
The study was aimed to investigate the influence of drug reamberin inclusion in the treatment regimen of patients with acute Epstein-Barr virus (EBV) infection on the effectiveness of therapy. Treatment results were analyzed in a group of 70 children aged 4-15 with a diagnosis of moderate to severe EBV infection. By the method of random sampling distribution, patients were divided into two comparable groups of 35 children, which were representative with respect to gender, age, date of admission, and conducted basic therapy...
2016: Eksperimental'naia i Klinicheskaia Farmakologiia
А V Panitskiy, S N Lukashenko, N Zh Kadyrova
The paper provides research results of (137)Cs and (90)Sr radionuclides concentrations in bodies of Lacertidae family lizards, inhabiting different parts of Semipalatinsk Test Site, and the parameters of these radionuclides' transfer into lizards' bodies. It shows that high activity concentration of radionuclides in lizards' bodies can be noticed if they live directly at locally contaminated areas. Since the distance from contaminated spots exceeds home range of the studied animals, no increased values of radionuclides' activity were found in the animal bodies...
May 2, 2016: Journal of Environmental Radioactivity
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