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Yu Yu Rusakov, I L Rusaskova
In this paper we have investigated the cumulative peculiarity of the "heavy atom on light atom" effect on the 13 C NMR chemical shifts, initiated by the adjacent chalcogens. For this purpose, the most accurate hybrid computational scheme for the calculation of chemical shifts of carbon nuclei, directly bonded with several heavy chalcogens, is introduced and attested on the representative series of molecules. The best hybrid scheme combines the nonrelativistic coupled cluster-based approach with the different types of corrections, including vibrational, solvent and relativistic...
February 7, 2018: Magnetic Resonance in Chemistry: MRC
Yu I Pigolkin, Zh V Dorosheva, N S Oganesyan, D V Gornostaev
The detection of grade II-III central obesity on a corpse in conjunction with the identification of two additional criteria (such as arterial hypertension and impaired glucose tolerance) provides, if combined with the autopsy data (including the visual reduction of muscular mass, the increased total amount of the adipose tissue, gynecomastia in men together with hypertrophied abdominal adipose tissue accumulation, decreased face and body pilosis), a basis for diagnostics of metabolic syndrome (MS). The objective parameters for this purpose are waist circumference measurements, corpse weight and height, the degree of visceral obesity, narrowing of the renal arteries as a result of their compression by the surrounding adipose tissue, and accumulation of epicardial fat confirmed by the results of the biochemical analysis...
2018: Sudebno-meditsinskaia Ekspertiza
E E Achkasov, A V Pugaev, Zh G Nabiyeva, S V Kalachev
AIM: To develop and justify optimal nutritional support in early phase of acute pancreatitis (AP). MATERIAL AND METHODS: 140 AP patients were enrolled. They were divided into groups depending on nutritional support: group I (n=70) - early enteral tube feeding (ETF) with balanced mixtures, group II (n=30) - early ETF with oligopeptide mixture, group III (n=40) - total parenteral nutrition (TPN). The subgroups were also isolated depending on medication: A - Octreotide, B - Quamatel, C - Octreotide + Quamatel...
2018: Khirurgiia
A S Axambayeva, L R Zhaparova, Zh S Shagyrova, E M Ramankulov, A V Shustov
Tyrosinases catalyze oxidation of phenols with a formation of biphenols, quinones, and highly polymerized melanins. Tyrosinases have prospects for industrial use to remove phenols, also in biosensors, in bioorganic synthesis, and for a production of biocompatible adhesives (medical glues). Despite growing fields of potential applications, a selection of commercially available tyrosinases are currently limited to a single enzyme which is isolated from fruiting bodies of mushrooms. This article describes a preparation of recombinant tyrosinase from a bacterium Verrucomicrobium spinosum using a heterologous expression in Escherichia coli...
January 6, 2018: Applied Biochemistry and Biotechnology
V O Buzunov, K M Loganovsky, L I Krasnikova, M O Bomko, Yu M Belyayev, Zh S Yaroshenko, T E Domashevska
Numerous scientific studies have been carried out since the ChNPP accident indicating that the last one has caused a severe psychosocial stress in survivors. Population of radioactively contaminated territories, people migrated from the areas of strict radiation control, and accident consequences clean up participants in 1986 1987 were covered by the conducted research projects. Nature of the stress herewith is polygenic and includes factors directly related to the Chernobyl catastrophe, and factors being a result of social and economic circumstances...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
D Bazyka
After the creation of the Academy of Medical Sciences of Ukraine in 1993 the Research Center for Radiation Medicine was among the first institutions to join the Academy (fig. 1). Estab lishing the Academy was among the first steps of the independent Ukrainian government and aimed to provide a high level health care for population. It was extremely needed for the minimization of Chornobyl medical consequences. This choice was related to a growing recognition of the scientific research in fulfilling the Сenter's mission - study of the effects of low dose radiation on human body and radiation protection of the exposed population...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
A I Shatokhin, M N Boichenko, T Zh Umbetov, S G Pak, E V Volchkova
DNA viruses have high oncogenic risk viruses; they cause emergence of Kaposi sarcoma, Lymphoma, Squamous cell carcinoma. HIV immunodeficiency promotes increase in frequency of such tumors. Etiotropic therapy of HIV patients considerably reduces prevalence of DNA viruses and a viral malignization.
2017: Stomatologii︠a︡
O V Kalyuzhin, Zh B Ponezheva, I V Semenova, O N Khokhlova, L V Serebrovskaya, T S Guseva, O V Parshina, V V Maleev
AIM: To determine whether there is a correlation of the composition of circulating lymphocyte subpopulations, the serum concentrations of interferon (IFN)-α, IFN-γ, and IFN-λ3, and the lymphocyte expression of types I and II IFN receptors with the species of a disease pathogen and the degree of liver fibrosis (LF) in patients with chronic hepatitis B (CHB) and in those with chronic hepatitis C (CHC). SUBJECTS AND METHODS: The investigation enrolled 44 patients with CHC, 9 patients with CHB, and 13 clinically healthy donors...
2017: Terapevticheskiĭ Arkhiv
Yuriy G Kim, Aliya Zh Baltabekova, Erzhan E Zhiyenbay, Altynai S Aksambayeva, Zhadyra S Shagyrova, Rinat Khannanov, Erlan M Ramanculov, Alexandr V Shustov
B18R protein of Vaccinia virus binds to type I interferons and inhibits activation of interferon-mediated signal transduction. Cells which have unimpaired interferon signaling such as primary cell cultures or some industrially important cell lines are capable of development of an antiviral state. An establishment of the antiviral state limits replication of RNA-viruses and can suppress replication of RNA vectors. The interferon inhibitor B18R effectively prevents the establishment of the antiviral state. For this reason, B18R has become a ubiquitous component of protocols for epigenetic reprogramming which use transfections of RNA replicons or mRNA...
2017: PloS One
M Yu Maksimova, Zh N Sermagambetova, S I Skrylev, P A Fedin, A Yu Koshcheev, V L Shchipakin, I A Sinicyn
AIM: To assess brain stem dysfunction in patients with hemodynamically significant stenosis of vertebral arteries (VA) using short latency brainstem auditory evoked potentials (BAEP). MATERIAL AND METHODS: The study group included 50 patients (mean age 64±6 years) with hemodynamically significant extracranial VA stenosis. RESULTS: Patients with hemodynamically significant extracranial VA stenosis had BAEP abnormalities including the elongation of interpeak intervals I-V and peak V latency as well as the reduction of peak I amplitude...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Zh T Isakova, E T Talaibekova, D A Asambaeva, A S Kerimkulova, O S Lunegova, N M Aldasheva, A A Aldashev
AIM: To analyze the association of genotype combinations of the polymorphic markers G276T in the ADIPOQ gene, Glu23Lys in the KCNJ11 gene, and IVS3C>T in the TCF7L2 gene with the development of type 2 diabetes mellitus (T2DM) in the Kyrgyz population. SUBJECTS AND METHODS: The investigation enrolled 23 Kyrgyz people, of whom there were 114 patients with T2DM and 109 without T2DM (a control group). T2DM was diagnosed in accordance with the WHO criteria (1999)...
2017: Terapevticheskiĭ Arkhiv
Trevor Wai-Kit Yung, Cynthia Y Y Lai, Ivan Neil Gomez, Valerie Loh, Jing Wang, Jacob Y C Chan, Karthikeyan Krishnamurthy, Benson Wui-Man Lau, Shamay S M Ng
Culture is thought to strongly influence the development of executive functions (EF), such that ethnic groups with similar cultural origins are generally assumed to exhibit comparable levels of EF performance. However, other characteristics, such as urbanization and Westernization, may also affect EF performance in societies comprising different ethnic groups, even if the ethnic groups share a similar cultural origin. The present study aimed to compare the perceptions of parents in three cities [China-Shenzhen (ZH group), China-Hong Kong (HK group), and Singapore (SG group)] regarding the EF performances of their children, all of whom share the same genetic and cultural (i...
November 24, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
A V Kislitsyna, A G Volkov, N Zh Dikopova, S S Akhmedbaeva, A L Shishmareva
Playing various musical instruments is the cause of an additional load that affects the condition of dentition and of all organs and body systems at large. Each group of instruments is known to exert a specific impact on the health of the musicians including the undesirable influence on the state of thir oral cavity, such as a change of occlusion and irritation of oral mucosa. Taken together, these effects contribute to the development of periodontal disease, one of the most common dental disorders. AIM: The objective of the present study was to evaluate the effectiveness of ozone therapy conducted with the use of the generator producing ozone under effect of ultraviolet radiation for the treatment of periodontitis in musicians-instrumentalists...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
V V Lavrova, S V Zinovieva, Zh V Udalova, E M Matveeva
The dynamics of expression of PR1 and PR6 genes, which are involved in the defense response of plants infected with the root-knot nematode Meloidogyne incognita, was studied in the "tomato-root-knot nematode" parasitic system. The invasion of the resistant plants was accompanied by an increased accumulation of transcripts of PR genes, which reflects their fast response to the penetration of nematode juveniles with subsequent development of an adequate defense response. In the susceptible plants, changes in the PR1 and PR6 gene activity induced by the nematode invasion were insignificant, which may be one of the causes of the disease...
September 2017: Doklady. Biochemistry and Biophysics
Vadim S Pokrovsky, Olga E Chepikova, Denis Zh Davydov, Andrey A Zamyatnin, Alexander N Lukashev, Elena V Lukasheva
Amino acids are essential components in various biochemical pathways. The deprivation of certain amino acids is an antimetabolite strategy for the treatment of amino acid-dependent cancers which exploits the compromised metabolism of malignant cells. This review summarizes recent progress in the relationship between amino acids metabolism and cancer therapy, with a particular focus on L-asparagine, L-methionine, L-arginine and L-lysine degrading enzymes and their formulations, which have been successfully used in the treatment of several types of cancer...
October 6, 2017: Current Medicinal Chemistry
Zh А Baigazinov, S N Lukashenko, S S Karatayev, А V Panitski, А S Mamyrbayeva, S А Baigazy, T Ye Kozhakhanov, L F Subbotina
Following a continuous intake of tritium (T) by laying hens' over a 55 day period, an increase of НТО concentration both in eggs and meat was observed over the first 2 weeks for intakes via inhalation and ingestion of water and grass meal. After this time, equilibrium of the T in these products occurred. It was found that when the intake of HTO is from water, air and grass meal, the ratio of its activity concentration in muscular tissue to that in eggs does not exceed 1, 4, and 6 respectively. The ratio of ОBТ concentration to that of НТО in the meat of hens (ОBТ/HTO) when intakes were from water, air and grass meal were 0...
November 2017: Journal of Environmental Radioactivity
S S Voznesenskiy, A Yu Popik, E L Gamayunov, T Yu Orlova, Zh V Markina, I V Postnova, Yu A Shchipunov
No abstract text is available yet for this article.
May 31, 2017: European Biophysics Journal: EBJ
Amy C Ladd, David G Brohawn, Ravindar R Thomas, Paula M Keeney, Stuart S Berr, Shaharyar M Khan, Francisco R Portell, Meiram Zh Shakenov, Patrick F Antkowiak, Bijoy Kundu, Nicholas Tustison, James P Bennett
Amyotrophic lateral sclerosis (ALS) is a generally fatal neurodegenerative disease of adults that produces weakness and atrophy due to dysfunction and death of upper and lower motor neurons. We used RNA-sequencing (RNA-seq) to analyze expression of all mitochondrial DNA (mtDNA)-encoded respiratory genes in ALS and CTL human cervical spinal cords (hCSC) and isolated motor neurons. We analyzed with RNA-seq mtDNA gene expression in human neural stem cells (hNSC) exposed to recombinant human mitochondrial transcription factor A (rhTFAM), visualized in 3-dimensions clustered gene networks activated by rhTFAM, quantitated their interactions with other genes and determined their gene ontology (GO) families...
May 13, 2017: Brain Research
Orazbek S Sakhov, Murat E Kuzhukeyev, Almat T Kodasbayev, Tolegen Zh Egemberdiev, Salim F Berkinbayev, Bekbolat K Zholdin, Serik A Alimbaev, Sholpan B Zhangelova, Rustam A Rakhimov, Daniyar I Makhanov, Yersyn T Sabitov, Dauren A Teleuov, Ruslan K Baisebenov, Arystan M Kuzhukeyev
This paper presents data on the nascence and development of the interventional cardiology service in Kazakhstan. It provides details of the structure of the Kazakhstan interventional cardiology service, staff training, the number of coronary and structural heart interventions for the period of 2010-2015, as well as the peculiarities of the capitation payment method. The number of coronary interventions is increasing year by year, though the number of intracoronary imaging techniques and intracoronary flow/pressure techniques remains inadequate...
May 15, 2017: EuroIntervention
S S Voznesenskiy, A Yu Popik, E L Gamayunov, T Yu Orlova, Zh V Markina, I V Postnova, Yu A Shchipunov
The biocompatible silica precursor tetrakis(2-hydroxyethyl)orthosilicate with ethylene glycol residues was used instead of the common alcohol-containing tetraethoxysilane for the first time to prepare a biorecognition element by entrapping the marine microalga Porphyridium purpureum into a silica matrix by a one-stage sol-gel procedure at conditions (pH, ionic strength, and temperature) appropriate for living cells. We show that the microalga immobilized in this way fully maintains its viability and functionality...
May 5, 2017: European Biophysics Journal: EBJ
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