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https://www.readbyqxmd.com/read/28291194/-clinical-associations-between-photoreceptor-status-and-visual-outcomes-in-diabetic-macular-edema
#1
A Zh Fursova, N V Chubar', M S Tarasov, I F Saifullina, G G Pustovaya
AIM: to investigate morphological changes and visual acuity response to ranibizumab therapy in patients with different OCT-types of diabetic macular edema (DME) as well as different state of the inner and outer photoreceptor segments (IS and OS) and the outer limiting membrane (OLM); to study relationships between functional and morphological parameters before and after the treatment; to study the effect of glycated hemoglobin levels on morphological parameters and ME duration. MATERIAL AND METHODS: The study included 113 patients (113 eyes) with DME, who underwent 3 once-monthly intravitreal injections of ranibizumab (the mean patient age, 63...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28290843/-influence-of-the-potassium-channels-activator-nicorandil-to-the-quality-of-life-in-patients-with-ishemic-heart-disease-and-stable-angina-pectoris
#2
Zh M Sizova, V L Zakharova, N V Kozlova, T S Kuchkina
The aim of the study to assess the influence of medicamentous therapy to the quality of life of ischemic heart disease patients with stable angina pectoris by activator potassium channels nicorandil in comparison with traditional therapy by isosorbide dinitrate. The study included 84 ischemic heart disease patients. Authors consider quality of life as an estimated category of state of the subject in an illness situation. The dynamic of physical and psychological components of quality of life are compared in ischemic heart disease patients under the treatment by nicorandil and isosorbide dinitrate...
June 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290806/-cardio-hepatic-syndrome-in-heart-failure-prevalence-pathogenesis-and-prognostic-significance
#3
Zh D Kobalava, S V Villevalde, A E Soloveva
In a framework of the concept of organ interactions great attention has been paid during recent years to interaction of the heart and liver. The term cardio-hepatic syndrome (CHS) designates the combination of clinical-laboratory signs of liver dysfunction and acute or chronic cardiac pathology. In this article, we present mechanisms and characteristics of CHS in acute and chronic heart failure (HF), data of large clinical studies and registries on prevalence, associations, and prognostic significance of cardiogenic disturbances of liver function in patients with HF...
December 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290795/-a-breakthrough-in-the-treatment-of-patients-with-heart-failure-with-reduced-ejection-fraction-the-clinical-significance-of-the-paradigm-hf-trial
#4
Zh D Kobalava, S V Villevalde, O I Lukina
The implementation into clinical practice of new therapeutic strategies that could improve the prognosis of patients with heart failure (HF) with reduced ejection fraction (HFrEF) remains relevant. Innovative approach is to restore imbalances of neurohumoral systems by inhibiting angiotensin II receptor and neprilysin. The review presents the role of the natriuretic peptides system in the HFrEF pathophysiology, historical approaches to neurohormonal modulation, clinical pharmacology of the first in the class of angiotensin receptor and neprilysin inhibitor sakubitril/valsartan...
February 2017: Kardiologiia
https://www.readbyqxmd.com/read/28252621/-association-of-the-polymorphic-marker-glu23lys-in-the-kcnj11-gene-with-hypertension-in-kyrgyz-patients
#5
Zh T Isakova, E T Talaibekova, D A Asambaeva, A S Kerimkulova, O S Lunegova, A A Aldashev
AIM: To study the association of the polymorphic marker Glu23Lys in the KCNJ11 with the development of hypertension in Kyrgyz patients. SUBJECTS AND METHODS: This case-control study enrolled 214 unrelated ethnic Kyrgyzes, in which a study group included 152 hypertensive patients (82 men and 70 women) and a control group consisted of 109 apparently healthy individuals (61 men and 48 women). The examinees' mean age was 55.2±10.1 years. Hypertension was verified when blood pressure (BP) was above 140/90 mm Hg...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28246373/serological-diagnosis-of-cystic-echinococcosis-in-cattle
#6
Aitbay K Bulashev, Zhanbolat A Suranshiev, Orken S Akibekov, Zhanara Zh Akanova, Gulmira A Abulgazimova
An IgM murine monoclonal antibody (MAb) was obtained against the excretory-secretory antigen (ES-Ag) of in vitro reared protoscoleces of Echinococcus granulosus (Batsch, 1786). Western blotting revealed that the MAb recognised a 20.6 kDa protein of this ES-Ag. The MAb was used in sandwich enzyme-linked immunosorbent assay (s-ELISA) for selective sensitisation of the solid phase with the protoscolex-specific protein from its ES-Ag and somatic antigen (S-Ag) to examine serum samples of 108 cows from a cystic echinococcosis (CE) endemic area for specific antibodies and to compare the results with those from necropsies and an indirect ELISA (i-ELISA)...
February 17, 2017: Folia Parasitologica
https://www.readbyqxmd.com/read/28208321/high-efficiency-%C3%AE-ray-flash-generation-via-multiple-laser-scattering-in-ponderomotive-potential-well
#7
Z Gong, R H Hu, Y R Shou, B Qiao, C E Chen, X T He, S S Bulanov, T Zh Esirkepov, S V Bulanov, X Q Yan
γ-ray flash generation in near-critical-density target irradiated by four symmetrical colliding laser pulses is numerically investigated. With peak intensities about 10^{23} W/cm^{2}, the laser pulses boost electron energy through direct laser acceleration, while pushing them inward with the ponderomotive force. After backscattering with counterpropagating laser, the accelerated electron is trapped in the electromagnetic standing waves or the ponderomotive potential well created by the coherent overlapping of the laser pulses, and emits γ-ray photons in a multiple-laser-scattering regime, where electrons act as a medium transferring energy from the laser to γ rays in the ponderomotive potential valley...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28201890/structure-property-relationships-in-cubic-cuprous-iodide-a-novel-view-on-stability-chemical-bonding-and-electronic-properties
#8
A Pishtshev, S Zh Karazhanov
Based on the combination of density functional theory and theory-group methods, we performed systematic modeling of γ-CuI structural design at the atomistic level. Being started from the metallic copper lattice, we treated a crystal assembly as a stepwise iodination process characterized in terms of a sequence of intermediate lattice geometries. These geometries were selected and validated via screening of possible structural transformations. The genesis of chemical bonding was studied for three structural transformations by analyzing the relevant changes in the topology of valence electron densities...
February 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28178629/plasma-methionine-depletion-and-pharmacokinetic-properties-in-mice-of-methionine-%C3%AE-lyase-from-citrobacter-freundii-clostridium-tetani-and-clostridium-sporogenes
#9
E A Morozova, N V Anufrieva, D Zh Davydov, M V Komarova, I N Dyakov, A N Rodionov, T V Demidkina, V S Pokrovsky
PK studies were carried out after a single i.v. administration of 500 and 1000 U/kg by measuring of MGL activity in plasma samples. L-methionine concentration was measured by mass spectrometry. After single i.v. injection of 500U/kg the circulating T1/2 of enzymes in mice varies from 73 to 123min. The AUC0-tinf values determined for MGL 500U/kg from C. freundii, C. tetani and C. sporogenes are 8.21±0.28, 9.04±0.33 and 13.88±0.39U/(ml×h), respectively. Comparison of PK parameters of three MGL sources in the dose of 500U/kg indicated the MGL C...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28144590/effects-of-hesperidin-as-a-radio-protector-on-apoptosis-in-rat-peripheral-blood-lymphocytes-after-gamma-radiation
#10
R Fardid, Zh Ghorbani, Gh Haddadi, A Behzad-Behbahani, R Arabsolghar, E Kazemi, M A Okhovat, S J Hosseinimehr
INTRODUCTION: Hesperidin (HES), as the most abundant flavonoid existing in the citrus, is widely used by human daily. The radio-protective effects of Hesperidin have been confirmed in various measurement systems. This study aimed to evaluate the effects of Hesperidin on the changes in the apoptosis level and expression of apoptotic genes target (bax, bcl-2 and ration of bax/bcl-2) in the peripheral blood lymphocytes of male rats after gamma radiation. MATERIALS AND METHODS: 64 male rats were divided into eight groups: Control, HES (100 mg/kg b...
December 2016: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/28105932/genes-of-susceptibility-to-early-neurodegenerative-changes-in-the-rat-retina-and-brain-analysis-by-means-of-congenic-strains
#11
Elena E Korbolina, Anna A Zhdankina, Anzhela Zh Fursova, Oyuna S Kozhevnikova, Natalia G Kolosova
BACKGROUND: There has been considerable interest in discovery of the genetic architecture of complex traits, particularly age-related neurodegenerative disorders. To predict disease risk and to understand its genetic basis in humans, it is necessary to study animal models. Our previous research on the accelerated-senescence OXYS strain has revealed two quantitative trait loci (QTLs) on rat chromosome 1 that are associated with early cataract and/or retinopathy as well as with behavioral abnormalities...
December 22, 2016: BMC Genetics
https://www.readbyqxmd.com/read/28058682/mi-1-gene-expression-in-tomato-plants-under-root-knot-nematode-invasion-and-treatment-with-salicylic-acid
#12
V V Lavrova, Zh V Udalova, E M Matveeva, F K Khasanov, S V Zinovieva
The dynamics of expression of two homologous genes Mi-1.1 and Mi-1.2 in the roots of resistant and susceptible tomato plants in non-invasion conditions and during invasion with the root-knot nematode M. incognita was studied. Nematode invasion was accompanied by a significant increase in the expression level of both genes; however, the accumulation of transcripts at the early stages of nematode invasion in the penetration of nematode juveniles to the roots was observed only in plants that contained the Mi-1...
November 2016: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28057654/protocol-for-a-prospective-controlled-observational-study-to-evaluate-the-influence-of-hypoxia-on-healthy-volunteers-and-patients-with-inflammatory-bowel-disease-the-altitude-ibd-study
#13
Stephan Vavricka, Pedro A Ruiz, Sylvie Scharl, Luc Biedermann, Michael Scharl, Cheryl de Vallière, Carsten Lundby, Roland H Wenger, Leonhard Held, Tobias M Merz, Max Gassmann, Thomas Lutz, Andres Kunz, Denis Bron, Adriano Fontana, Laura Strauss, Achim Weber, Michael Fried, Gerhard Rogler, Jonas Zeitz
INTRODUCTION: Inflammatory bowel disease (IBD) is a chronic intestinal disorder, often leading to an impaired quality of life in affected patients. The importance of environmental factors in the pathogenesis of IBD, including their disease-modifying potential, is increasingly recognised. Hypoxia seems to be an important driver of inflammation, as has been reported by our group and others. The aim of the study is to evaluate if hypoxia can alter disease activity of IBD measured by Harvey-Bradshaw Activity Index in Crohn's disease (increase to ≥5 points) and the partial Mayo Score for ulcerative colitis (increase to ≥2 points)...
January 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28027545/social-and-psychological-state-of-the-chornobyl-clean-up-workers-risk-factors-for-negative-changes
#14
V O Buzunov, K N Loganovsky, L I Krasnikova, M O Bomko, Yu M Belyaev, Zh S Yaroshenko, T Ye Domashevska
It is generally recognized that the Chornobyl nuclear accident caused strong psychosocial stress affecting the entire population of Ukraine, primarily people involved in recovery operations. But what are the reasons? What is the struc ture of stressors? What are their social, medical and biological consequences, what are strategy and preventive meas ures? Issues that require special research and development. OBJECTIVE: To study social and psychological state of the Chornobyl cleanup workers 1986-1987, and to determine regularities of changes and dangerous risk factors...
December 2016: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/27898856/the-effect-of-zilpaterol-hydrochloride-supplementation-on-energy-metabolism-and-nitrogen-and-carbon-retention-of-steers-fed-at-maintenance-and-fasting-intake-levels
#15
L J Walter, N A Cole, J S Jennings, J P Hutcheson, B E Meyer, A N Schmitz, D D Reed, T E Lawrence
An indirect calorimetry trial examined energy metabolism, apparent nutrient digestibility, C retention (CR), and N retention (NR) of cattle supplemented with zilpaterol hydrochloride (ZH). Beef steers ( = 20; 463 ± 14 kg) blocked ( = 5) by weight and source were individually fed and adapted to maintenance energy intake for 21 d before allotment to ZH (90 mg/steer∙d) or no β-adrenergic agonist treatment (control [CONT]) for 20 d (455 ± 14 kg at the start of treatment). Respiration chambers = 4 were used to quantify heat production (HP) during maintenance (d 12 to 16 of the ZH period) and fasting heat production (FHP; d 19 to 20 of ZH period; total 4 d of fast)...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27878492/collagen-1-membrane-for-replacing-the-bladder-wall
#16
V I Kirpatovskii, A Yu Efimenko, V Yu Sysoeva, I S Mudraya, D M Kamalov, Zh A Akopyan, A A Kamalov
We studied the possibility of using membrane fabricated from type 1 collagen isolated from cattle tissues (group 1) or porcine tissues (group 2) for replacement of the resected bladder wall defect in rabbits in order to retain functional volume of the organ. Satisfactory take of both types of collagen membranes with formation of competent anastomosis was observed. Histological studies revealed inflammatory process in the bladder wall at the site of contact with the implanted membrane (more pronounced in case of membranes from cattle tissues) that decreased by day 21 of the experiment...
November 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27862329/exome-sequencing-identifies-fatp1-mutation-in-melkersson-rosenthal-syndrome
#17
LETTER
X G Xu, L P Guan, Y Lv, Y S Wan, Y Wu, R Q Qi, Zh G Liu, J G Zhang, Y L Chen, F P Xu, X Xu, Y H Li, L Geng, X H Gao, H D Chen
No abstract text is available yet for this article.
November 11, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27835013/analyzing-the-cp-nature-of-a-new-scalar-particle-via-s%C3%A2-zh-decays
#18
Martin Bauer, Matthias Neubert, Andrea Thamm
Scalar particles S that are singlets under the standard model gauge group are generic features of many models of fundamental physics, in particular, as possible mediators to a hidden sector. We show that the decay S→Zh provides a powerful probe of the CP nature of the scalar, because it is allowed only if S has CP-odd interactions. We perform a model-independent analysis of this decay using an effective Lagrangian and compute the relevant Wilson coefficients arising from integrating out heavy fermions to one-loop order...
October 28, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27801419/-ovarian-reserve-and-adipokine-levels-in-reproductive-aged-obese-women
#19
A K Durmanova, N K Otarbaev, A Kaiyrlykyzy, K Kh Zhangazieva, Zh N Ibraeva, G B Donenbaeva, Zh T Zhusupova, A S Saidakhmetov, G Sh Temirgalieva, Zh K Salykbaeva, Zh M Tazhigulova, A M Ensebaeva, K K Seksembaeva, O K Vasilenko, S Timanova, B Akkozhina
AIM: To investigate the relationship of the ovarian reserve to the levels of adipokines and sex hormones in reproductive-aged women with abdominal obesity. SUBJECTS AND METHODS: A total of 157 women aged 18 to 45 years with a body mass index (BMI) of more than 30 kg/m2 were examined (a study group). A control group consisted of 93 women aged 18-45 years with a BMI of less than 25 kg/m2. Anthropometric and carbohydrate and lipid metabolic parameters and the levels of sex hormones, anti-Müllerian hormone, resistin, and adiponectin were investigated...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27636763/clinical-microbiological-research-of-action-ozone-therapy-and-light-emetting-diode-radiation-of-red-range-630-nanometers-on-microflora-of-the-hole-extracted-toothatalveolitis-and-limited-osteomyelitis-of-jaws
#20
Yu I Chergeshtov, V N Tsarev, A G Volkov, A S Nosik, N Zh Dikopova, D A Malanchuk
As a result of cliniko-microbiological research the data testifying to substantial improvement of efficiency of antimicrobictherape at inclusion in a complex of medical actions at alveolitis and the limited osteomyelitis of a jow ozone therapy in a combination with a light-emettinf diode irradiation of the hole extracted teeth red ( 630 nanometers) are obtained by light.
2016: Stomatologii︠a︡
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