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Liyan Zhang, Shuai Li, Minmin Dong, Yao Jiang, Ru Li, Shuo Zhang, Xiaoxia Lv, Lijun Chen, Hua Wang
A facile and efficient enzymatic reconstitution methodology has been proposed for high-catalysis peroxidase mimics by remolding the redox active centers of heme-containing proteins with the in-site biomineralized gold using hemoglobin (Hb) as a model. Catalytic hemin (Hem) was extracted from the active centers of Hb for the gold biomineralization and then reconstituted into apoHb to yield the Hem-Au@apoHb nanocomposites showing dramatically improved intrinsic catalysis and electrocatalysis over natural Hb and Hem...
September 22, 2016: Biosensors & Bioelectronics
Mohammad Hossein Khosropanah, Amin Dinarvand, Afsaneh Nezhadhosseini, Alireza Haghighi, Sima Hashemi, Fereidon Nirouzad, Sepideh Khatamsaz, Maliheh Entezari, Mehrdad Hashemi, Hossein Dehghani
Cancer is one of the main causes of mortality in the world which appears by the effect of enviromental physico-chemical mutagen and carcinogen agents. The identification of new cytotoxic drug with low sid effects on immune system has developed as important area in new studies of immunopharmacology. Curcumin is a natural polyphenol with anti-oxidative, anti-inflammatory and anti-cancer properties. Its therapeutic potential is substantially hindered by the rather low water solubility and bioavailability, hence the need for suitable carriers...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Manuel Luque-Ramírez, Héctor F Escobar-Morreale
: Background The prevalence of adrenal hyperandrogenism (AH), as defined by increased circulating dehydroepiandrosterone-sulfate (DHEAS) levels, ranges from 15 to 45% in women with polycystic ovary syndrome PCOS. METHODS: The aim of this review is to update the pathogenesis and consequences of AH in PCOS, from molecular genetics to the clinical setting. RESULTS: Mounting evidence derived from animal models suggests that genetically or enviromentally determined prenatal androgen excess, by influencing the hormonal and metabolic phenotype of susceptible female fetuses later in life, may be the capital event for the development of AH in PCOS...
July 20, 2016: Current Pharmaceutical Design
Burcu Artunc-Ulkumen, Safiye Ulucay, Halil Gursoy Pala, Sirri Cam
OBJECTIVE: Gestational diabetes mellitus (GDM) is characterized with insulin resistance which is diagnosed during pregnancy. Although pregnancy is a diabetogenic state, not all women develop GDM. Genetic factors together with enviromental factors cause the maladaptation of maternal pancreas to this diabetogenic state and GDM develops. ADAMTS-9 is a recently recognized molecule whose genetic variants have risk of GDM. Decreased levels have already been shown in fetal membranes. Maternal serum levels of this protein have not been studied yet...
August 23, 2016: Journal of Maternal-fetal & Neonatal Medicine
Muharrem Burak Baytunca, Tuğba Donuk, Serpil Erermiş
PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections) syndrome is a disorder seen before adolescence that possesses an abrupt onset of obsessive-compulsive disorder symptoms and/or tics. Swedo and colleagues defined this disorder in 1998 as a syndrome related to Group A streptoccoccus (GAS) infection with neurological issues, such as motor hyperactivation and choreiform movements. The progress of the disorder may be described as wax-and-waning, apart from abrupt onset, and this relapse and remission course is associated with exacerbating infections, according to the creators of PANDAS syndrome...
2016: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
John J Kilbane, Benjamin Stark
Biological desulfurization (biodesulfurization) of dibenzothiophene (DBT) by the 4S pathway is a model system for an enviromentally benign way to lower the sulfur content of petroleum. Despite a large amount of effort the efficiency of the 4S pathway is still too low for a commercial oil biodesulfurization process, but the 4S pathway could potentially be used now for commercial processes to produce surfactants, antibiotics, polythioesters and other chemicals and for the detoxification of some chemical warfare agents...
August 2016: World Journal of Microbiology & Biotechnology
Derya Çamur, Çağatay Güler, Songül Acar Vaizoğlu, Betül Özdilek
An increase in enviromental pollution may lead to mercury toxicity of fish origin due to the accumulative nature of methylmercury in fish. The main sources of human exposure to organic mercury compounds are contaminated fish and other seafoods. This descriptive study was planned to determine mercury levels in anchovy and in hair samples from individuals with different fish consumption habits, and to evaluate those individuals in terms of toxic effects. For that purpose, we analyzed 100 anchovies from the Black Sea and 100 anchovies from the Sea of Marmara, and assessed 25 wholesale workers in fish markets and 25 cleaning firm employees from both Ankara and Istanbul...
July 2016: Toxicology and Industrial Health
Ye Zhang, Xiaodan Li, Shumei Zou, Hong Bo, Libo Dong, Rongbao Gao, Dayan Wang, Yuelong Shu
Abstract: To investigate the distribution of avian influenza virus in environmental samples from live poultry markets (LPM) in China, samples were collected and tested by nucleic acid during 2009-2013 season. Each sample was tested by real-time RT PCR using flu A specific primers. If any real-time PCR was positive, the sample was inoculated into specific-pathogen-free (SPF) embryonated chicken eggs for viral isolation. The results indicated that the positive rate of nucleic acid in enviromental samples exhibited seasonality...
November 2015: Bing du Xue Bao, Chinese Journal of Virology
Yoav Ben-Shlomo, Frank de Vocht
No abstract text is available yet for this article.
May 2016: Movement Disorders: Official Journal of the Movement Disorder Society
K B de Almeida Lopes, V Carpentieri-Pipolo, T H Oro, E Stefani Pagliosa, G Degrassi
AIMS: Assess the diversity of the culturable endophytic bacterial population associated with transgenic and nontransgenic soybean grown in field trial sites in Brazil and characterize them phenotypically and genotypically focusing on characteristics related to plant growth promotion. METHODS AND RESULTS: Endophytic bacteria were isolated from roots, stems and leaves of soybean cultivars (nontransgenic (C) and glyphosate-resistant (GR) transgenic soybean), including the isogenic BRS133 and BRS245RR...
March 2016: Journal of Applied Microbiology
Levent Mete, Özyıl Sarıkaya, Almıla Erol
AIM: The aim of this study was to compare deficit schizophrenia patients with non-deficit schizophrenia patients for negative and positive symptome scores, rate of summer births, and rate of familial history of psychosis. METHOD: 110 patients with schizophrenia diagnosed via Structured Clinical Interview for DSM-IV (SCID-I) aged between 18-65 were included in the study. All the patients were evaluated using the Scale for the Assessment of Negative Symptoms (SANS), Scale for the Assessment of Positive Symptoms (SAPS), and The Schedule for the Deficit Syndrome (SDS), and sociodemographic information was obtained...
2015: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
Krystyna Zeńczak-Praga, Małgorzata Zgorzalewicz-Stachowiak, Kinga Cesar
UNLABELLED: Cerebral palsy (CP) is still significant health and social issue in the world. Adults who suffer from that illness have problem with mobility which make their functioning much harder. Common symptoms include spasticity, chronic pain of musculoskeletal system, disturbance of sensation, epilepsy or mental retardation. AIM: The aim of the study was analysis of assistive devices used by patients with CP through childhood and adulthood. The results were compared with the situation in this field of CP patients in other countries...
November 2015: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Nadezda Petejova, Arnost Martinek
BACKGROUND AND AIMS: The global incidence of renal cell cancer is increasing annually and the causes are multifactorial. Early diagnosis and successful urological procedures with partial or total nephrectomy can be life-saving. However, only up to 10% of RCC patients present with characteristic clinical symptoms. Over 60% are detected incidentally in routine ultrasound examination. The question of screening and preventive measures greatly depends on the cause of the tumor development...
June 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Benjamín Reyes Fernández, Sonia Lippke, Nina Knoll, Emanuel Blanca Moya, Ralf Schwarzer
BACKGROUND: We examined a brief educational intervention addressing hand hygiene self-regulatory mechanisms, and evaluated which psychological mechanisms may lead to hand hygiene behaviours. METHODS: Two hundred forty two students (mean age = 21 years, SD = 3.9) received either an experimental (n = 149) or a control condition on action control and planning (n = 93). Hand hygiene, coping planning, and action control were measured at baseline and six weeks later...
2015: BMC Public Health
Zhang Chen, Huidong Li, Lin Chu, Chenbin Liu, Shenglian Luo
A simple and sensitive colorimetric assay for Pb2+ detection has been reported using glutathione protected silver nanoparticles (AgNPs) by salt amplification. The naked AgNPs aggregate under the influence of salt. Glutathione (GSH) can bind to AgNPs via Ag-S bond, helping AgNPs to against salt-induced aggregation. However, GSH binding to AgNPs can be compromised by the interaction between Pb2+ and GSH. As a result, Pb2+-mediated aggregation of AgNPs under the influence of salt is reflected by the UV-Visible spectrum, and the qualitative and quantitative detection for Pb2+ is accomplished, with the detection range 0...
February 2015: Journal of Nanoscience and Nanotechnology
Ali Atan, Melih Balcı
The frequency of stone disease in childhood ranges between 0.1-5 percent. Stone disease occurs as a result of enviromental, metabolic, anatomical, infectious and nutritional factors. Percutaneous nephrolitotomy, uretherorenoscopy, laparoscopic surgery, open surgery and extracorporeal shock wave lithothripsy are treatment alternatives for stone disease during childhood. However, these methods are not completely innocent. Some complications may occur after these procedures. These procedures are generally not cost- effective...
March 2015: Turkish Journal of Urology
Wojciech Guzikowski, Małgorzata I Szynkowska, Hanna Motak-Pochrzęst, Aleksandra Pawlaczyk, Stanisław Sypniewski
INTRODUCTION: An analysis of lead, zinc, cadmium and other trace elements in semen of men from infertile couples was performed to determine the association between abnormal semen parameters and enviromental or occupational exposure to some trace metals. MATERIAL AND METHODS: Presence of manganese, cobalt, nickel, copper, zinc, molybdenum, cadmium, tin and lead was measured in seminal plasma of 34 men from infertile couples using spectrometry with time-of-flight analysis...
June 19, 2015: Archives of Medical Science: AMS
Umut Can Oz, Burcu Devrim, Asuman Bozkır, Kandemir Canefe
Effective clinical utilisation of non-steroidal anti-inflammatory drugs, such as diclofenac sodium (DS) is significantly limited by their ulcerogenic potential and poor bioavailability after oral administration. The objective of this work was to develop reconstitutable pediatric suspensions of DS-loaded microspheres prepared with an acrylic polymer (Eudragit RS) for improved pediatric delivery of DS. The microspheres were prepared by the water-in-oil-in-water or solid-in-oil-in-water emulsion techniques. Enviromental scanning electron microscopy observations clearly showed that microspheres have spherical shape...
2015: Journal of Microencapsulation
Bilal Bakır, Mustafa Alparslan Babayiğit, Ömer Faruk Tekbaş, Recai Oğur, Abdullah Kılıç, Serdar Ulus
AIM: This study was performed with the objective to determine the levels of some physical hazards in primary schools. MATERIAL AND METHODS: This study is a cross-sectional field survey. In this study which was conducted in 31 primary schools selected by appropriate sampling from the district of Keçiören of the province of Ankara, measurements related with temperature, light, electromagnetic field (EMF) and noise levels were done at hundreds of points. Approval was obtained from Gülhane Military Medical Faculty Ethics Committee (2007/97)...
September 2014: Türk Pediatri Arşivi
Hossein Dehghani, Mehrdad Hashemi, Maliheh Entezari, Afshin Mohsenifar
Cancer is one of the main causes of mortality in the world which is created by the effect of enviromental physico-chemical mutagen and carcinogen agents. The identification of new cytotoxic drugs with low side effects on immune system has developed as important area in new studies of pharmacology. Thymoquinone (TQ), derived from the medicinal spice Nigella sativa (also calledt black cumin) exhibit anti-inflammatory and anti-cancer activities. In this study we employed nanogel-based nanoparticle approach to improve upon its effectiveness...
2015: Iranian Journal of Pharmaceutical Research: IJPR
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