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G Benito, J C Sáez, J B Blázquez, J Quiñones
The objective of this study is the verification of the operation of a radiation monitoring network conformed by several sensors. The malfunction of a surveillance network has security and economic consequences, which derive from its maintenance and could be avoided with an early detection. The proposed method is based on a kind of multivariate distance, and the verification for the methodology has been tested at CIEMAT's local radiological early warning network.
December 11, 2017: Radiation Protection Dosimetry
Mudasir Ahmad, Bisma Ashraf, Asir Gani, Adil Gani
In the present study, the saffron anthocyanins were encapsulated in β-glucan and β-cyclodextrin by spray drying technique to achieve their stability under adverse gastro-environmental conditions. The microcapsules were subjected to simulated gastric conditions and release behavior of monomeric anthocyanins, antioxidants and phenols were studied. The structural properties of microcapsules were analyzed by SEM and ATR-FTIR spectroscopy. The particle size distribution, density, color, encapsulation efficiency and powder yield of samples were also evaluated...
April 1, 2018: International Journal of Biological Macromolecules
Jamie E Coborn, Monica M Houser, Claudio E Perez-Leighton, Jennifer A Teske
PURPOSE OF REVIEW: The growing prevalence of obesity, inadequate sleep and sleep disorders together with the negative impact of lack of sleep on overall health highlights the need for therapies targeted towards weight gain due to sleep loss. RECENT FINDINGS: Sex disparities in obesity and sleep disorders are present; yet, the role of sex is inadequately addressed and thus it is unclear whether sensitivity to sleep disruption differs between men and women. Like sex, environmental factors contribute to the development of obesity and poor sleep...
December 2017: Current Obesity Reports
Laura Camacho-Jiménez, Edna Sánchez-Castrejón, Fernando Díaz, Manuel B Aguilar, Ma Enriqueta Muñoz-Márquez, Elizabeth Ponce-Rivas
Crustacean hyperglycemic hormones (CHHs) are multifunctional neuropeptides ubiquitous in crustaceans. In Litopenaeus vannamei, CHH-B2 is a CHH eyestalk isoform whose expression has been shown to vary with enviromental conditions, suggesting its relevance for ecophysiological performance of shrimp, controlling processes related to metabolism and osmo-ionic regulation. To study the involvement of CHH-B2 in these processes, we cloned and expressed a recombinant version with a free C-terminal glycine (rCHH-B2-Gly) in the methylotrophic yeast Pichia pastoris...
November 1, 2017: General and Comparative Endocrinology
Linya Liu, Yacheng Huang, Xiaolong Huang, Jianghua Yang, Wenqiang Wu, Yun Xu, Ziwen Cong, Jun Xie, Wei Xia, Dongyi Huang
Dioscorin is one of the major soluble proteins in yam tubers. Unlike other well-known plant storage proteins, such as patatin and sporamin, dioscorin is argued for its function as storage proteins, and the molecular mechanisms underlying its expressional complexity are little understood. In this study, we isolated five dioscorin genes from Dioscorea alata L., comprising three class A (Da-dio1, -3 and -4) and two class B (Da-dio2 and -5) isoforms. Expressions of all dioscorin genes gradually decreased in mother tubers during yam sprouting and regrowth...
July 20, 2017: International Journal of Molecular Sciences
Saganuwan Alhaji Saganuwan
Central nervous system (CNS) disorders are on increase perhaps due to genetic, enviromental, social and dietetic factors. Unfortunately, a large number of CNS drugs have adverse effects such as addiction, tolerance, psychological and physical dependence. In view of this, literature search was carried out with a view to identifying functional chemical groups that may serve as lead molecule for synthesis of compounds that may have CNS activity. The search revealed that heterocycles that have heteroatoms such as nitrogen (N), sulphur (S) and oxygen (O) form the largest class of organic compounds...
May 2, 2017: Central Nervous System Agents in Medicinal Chemistry
Guoming Cao, Fujian Xu, Shanling Wang, Kailai Xu, Xiandeng Hou, Peng Wu
Gold nanoparticles (AuNPs)-based colorimetric assays are of particular interest since molecular events can be easily read out with the color changes of AuNPs by the naked eye. However, the molecular recognitions occur almost exclusively in the liquid phase (i.e., the interaction between target analytes and AuNPs is always proceeded in the presence of the sample matrix). Since the aggregation of the unmodified AuNPs is prone to be influenced by the ionic strength of the solution, sample matrix will cause undesirable interference...
March 31, 2017: Analytical Chemistry
Xuemei Wang, Pengfei Huang, Xiaomin Ma, Huan Wang, Xiaoquan Lu, Xinzhen Du
Novel magnetic mesoporous molecularly imprinted polymers (MMIPs) with core-shell structure were prepared by simple surface molecular imprinting polymerization using tetrabromobisphenol-S (TBBPS) as the template. The MMIPs-TBBPS were characterized by fourier-transform infrared spectrometry (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), N2 adsorption-desorption transmission, and vibrating sample magnetometry. The resultant MMIPs-TBBPS were successfully applied magnetic solid-phase extraction (MSPE) coupled with HPLC determination of TBBPS in spiked real water samples with recoveries of 77...
May 1, 2017: Talanta
Rachele Tamburino, Monica Vitale, Alessandra Ruggiero, Mauro Sassi, Lorenza Sannino, Simona Arena, Antonello Costa, Giorgia Batelli, Nicola Zambrano, Andrea Scaloni, Stefania Grillo, Nunzia Scotti
BACKGROUND: Drought is a major constraint for plant growth and crop productivity that is receiving an increased attention due to global climate changes. Chloroplasts act as environmental sensors, however, only partial information is available on stress-induced mechanisms within plastids. Here, we investigated the chloroplast response to a severe drought treatment and a subsequent recovery cycle in tomato through physiological, metabolite and proteomic analyses. RESULTS: Under stress conditions, tomato plants showed stunted growth, and elevated levels of proline, abscisic acid (ABA) and late embryogenesis abundant gene transcript...
February 10, 2017: BMC Plant Biology
Liyan Zhang, Shuai Li, Minmin Dong, Yao Jiang, Ru Li, Shuo Zhang, Xiaoxia Lv, Lijun Chen, Hua Wang
A facile and efficient enzymatic reconstitution methodology has been proposed for high-catalysis peroxidase mimics by remolding the redox active centers of heme-containing proteins with the in-site biomineralized gold using hemoglobin (Hb) as a model. Catalytic hemin (Hem) was extracted from the active centers of Hb for the gold biomineralization and then reconstituted into apoHb to yield the Hem-Au@apoHb nanocomposites showing dramatically improved intrinsic catalysis and electrocatalysis over natural Hb and Hem...
January 15, 2017: Biosensors & Bioelectronics
Mohammad Hossein Khosropanah, Amin Dinarvand, Afsaneh Nezhadhosseini, Alireza Haghighi, Sima Hashemi, Fereidon Nirouzad, Sepideh Khatamsaz, Maliheh Entezari, Mehrdad Hashemi, Hossein Dehghani
Cancer is one of the main causes of mortality in the world which appears by the effect of enviromental physico-chemical mutagen and carcinogen agents. The identification of new cytotoxic drug with low sid effects on immune system has developed as important area in new studies of immunopharmacology. Curcumin is a natural polyphenol with anti-oxidative, anti-inflammatory and anti-cancer properties. Its therapeutic potential is substantially hindered by the rather low water solubility and bioavailability, hence the need for suitable carriers...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Manuel Luque-Ramírez, Héctor F Escobar-Morreale
BACKGROUND: The prevalence of adrenal hyperandrogenism (AH), as defined by increased circulating dehydroepiandrosterone-sulfate (DHEAS) levels, ranges from 15 to 45% in women with polycystic ovary syndrome (PCOS). METHODS: The aim of this review is to update the pathogenesis and consequences of AH in PCOS, from molecular genetics to the clinical setting. RESULTS: Mounting evidence derived from animal models suggests that genetically or enviromentally determined prenatal androgen excess, by influencing the hormonal and metabolic phenotype of susceptible female fetuses later in life, may be the capital event for the development of AH in PCOS...
2016: Current Pharmaceutical Design
Burcu Artunc-Ulkumen, Safiye Ulucay, Halil Gursoy Pala, Sirri Cam
OBJECTIVE: Gestational diabetes mellitus (GDM) is characterized with insulin resistance which is diagnosed during pregnancy. Although pregnancy is a diabetogenic state, not all women develop GDM. Genetic factors together with enviromental factors cause the maladaptation of maternal pancreas to this diabetogenic state and GDM develops. ADAMTS-9 is a recently recognized molecule whose genetic variants have risk of GDM. Decreased levels have already been shown in fetal membranes. Maternal serum levels of this protein have not been studied yet...
June 2017: Journal of Maternal-fetal & Neonatal Medicine
Muharrem Burak Baytunca, Tuğba Donuk, Serpil Erermiş
PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections) syndrome is a disorder seen before adolescence that possesses an abrupt onset of obsessive-compulsive disorder symptoms and/or tics. Swedo and colleagues defined this disorder in 1998 as a syndrome related to Group A streptoccoccus (GAS) infection with neurological issues, such as motor hyperactivation and choreiform movements. The progress of the disorder may be described as wax-and-waning, apart from abrupt onset, and this relapse and remission course is associated with exacerbating infections, according to the creators of PANDAS syndrome...
2016: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
John J Kilbane, Benjamin Stark
Biological desulfurization (biodesulfurization) of dibenzothiophene (DBT) by the 4S pathway is a model system for an enviromentally benign way to lower the sulfur content of petroleum. Despite a large amount of effort the efficiency of the 4S pathway is still too low for a commercial oil biodesulfurization process, but the 4S pathway could potentially be used now for commercial processes to produce surfactants, antibiotics, polythioesters and other chemicals and for the detoxification of some chemical warfare agents...
August 2016: World Journal of Microbiology & Biotechnology
Derya Çamur, Çağatay Güler, Songül Acar Vaizoğlu, Betül Özdilek
An increase in enviromental pollution may lead to mercury toxicity of fish origin due to the accumulative nature of methylmercury in fish. The main sources of human exposure to organic mercury compounds are contaminated fish and other seafoods. This descriptive study was planned to determine mercury levels in anchovy and in hair samples from individuals with different fish consumption habits, and to evaluate those individuals in terms of toxic effects. For that purpose, we analyzed 100 anchovies from the Black Sea and 100 anchovies from the Sea of Marmara, and assessed 25 wholesale workers in fish markets and 25 cleaning firm employees from both Ankara and Istanbul...
July 2016: Toxicology and Industrial Health
Ye Zhang, Xiaodan Li, Shumei Zou, Hong Bo, Libo Dong, Rongbao Gao, Dayan Wang, Yuelong Shu
Abstract: To investigate the distribution of avian influenza virus in environmental samples from live poultry markets (LPM) in China, samples were collected and tested by nucleic acid during 2009-2013 season. Each sample was tested by real-time RT PCR using flu A specific primers. If any real-time PCR was positive, the sample was inoculated into specific-pathogen-free (SPF) embryonated chicken eggs for viral isolation. The results indicated that the positive rate of nucleic acid in enviromental samples exhibited seasonality...
November 2015: Bing du Xue Bao, Chinese Journal of Virology
Yoav Ben-Shlomo, Frank de Vocht
No abstract text is available yet for this article.
May 2016: Movement Disorders: Official Journal of the Movement Disorder Society
K B de Almeida Lopes, V Carpentieri-Pipolo, T H Oro, E Stefani Pagliosa, G Degrassi
AIMS: Assess the diversity of the culturable endophytic bacterial population associated with transgenic and nontransgenic soybean grown in field trial sites in Brazil and characterize them phenotypically and genotypically focusing on characteristics related to plant growth promotion. METHODS AND RESULTS: Endophytic bacteria were isolated from roots, stems and leaves of soybean cultivars (nontransgenic (C) and glyphosate-resistant (GR) transgenic soybean), including the isogenic BRS133 and BRS245RR...
March 2016: Journal of Applied Microbiology
Levent Mete, Özyıl Sarıkaya, Almıla Erol
AIM: The aim of this study was to compare deficit schizophrenia patients with non-deficit schizophrenia patients for negative and positive symptome scores, rate of summer births, and rate of familial history of psychosis. METHOD: 110 patients with schizophrenia diagnosed via Structured Clinical Interview for DSM-IV (SCID-I) aged between 18-65 were included in the study. All the patients were evaluated using the Scale for the Assessment of Negative Symptoms (SANS), Scale for the Assessment of Positive Symptoms (SAPS), and The Schedule for the Deficit Syndrome (SDS), and sociodemographic information was obtained...
2015: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
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