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https://www.readbyqxmd.com/read/28503309/are-there-two-forms-of-isometric-muscle-action-results-of-the-experimental-study-support-a-distinction-between-a-holding-and-a-pushing-isometric-muscle-function
#1
Laura V Schaefer, Frank N Bittmann
BACKGROUND: In isometric muscle function, there are subjectively two different modes of performance: one can either hold isometrically - thus resist an impacting force - or push isometrically - therefore work against a stable resistance. The purpose of this study is to investigate whether or not two different isometric muscle actions - the holding vs. pushing one (HIMA vs PIMA) - can be distinguished by objective parameters. METHODS: Ten subjects performed two different measuring modes at 80% of MVC realized by a special pneumatic system...
2017: BMC Sports Science, Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28472638/smart-chemistry-based-nanosized-drug-delivery-systems-for-systemic-applications-a-comprehensive-review
#2
REVIEW
Thiruganesh Ramasamy, Hima Bindu Ruttala, Biki Gupta Kanu, Bijay Kumar Poudel, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
This review focuses on the smart chemistry that has been utilized in developing polymer-based drug delivery systems over the past 10years. We provide a comprehensive overview of the different functional moieties and reducible linkages exploited in these systems, and outline their design, synthesis, and application from a therapeutic efficacy viewpoint. Furthermore, we highlight the next generation nanomedicine strategies based on this novel chemistry.
May 1, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28444602/bioactive-guided-fractionation-of-diols-from-streptomyces-sp-msl
#3
Raja Hima Bindhu Madasu, Vijayalakshmi Muvva, Rajesh Kumar Munaganti, Kumar Reddy Dorigondla, Venkateswarlu Yenamandra
An actinomycete strain with a great potential to produce bioactive compounds isolated from a laterite soil was identified as Streptomyces sp. MSL based on 16S rDNA sequence analysis. Secondary metabolites produced by the strain in optimized nutrient broth were extracted and analyzed by chromatographic and spectroscopic techniques. Among the different fractions, four diols, viz., (1) (2R,3R)-2,3-Butanediol, (2) (2R,3S)-2,3-Butanediol, (3) 2,3-dimethyl-2,3-butanediol (Pinacol), and (4) (3R)-1,3-Butanediol exhibited good antimicrobial activity...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28440229/pigmented-fungiform-papillae-in-mother-and-daughter
#4
Hima Gopinath, Gatha M Upadya
No abstract text is available yet for this article.
April 19, 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28414054/endothelium-dependent-vasorelaxant-effect-of-procyanidin-b2-on-human-internal-mammary-artery
#5
Aleksandra Novakovic, Marija Marinko, Goran Jankovic, Ivan Stojanovic, Predrag Milojevic, Dragoslav Nenezic, Vladimir Kanjuh, Qin Yang, Guo-Wei He
The aim of the present study was to investigate and characterize vasorelaxant effect of procyanidin B2 on human internal mammary artery (HIMA) as one of the mechanisms of its protective effect against vascular risk. Procyanidin B2 induced strong concentration-dependent relaxation of HIMA rings pre-contracted by phenylephrine. Pretreatment with L-NAME, a NO synthase inhibitor, hydroxocobalamin, a NO scavenger, and ODQ, an inhibitor of soluble guanylate cyclase, significantly inhibited procyanidin B2-induced relaxation of HIMA, while indomethacin, a cyclooxygenase inhibitor, considerably reduced effects of low concentrations...
April 13, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28411841/the-molecular-revolution-in-cutaneous-biology-the-era-of-genome-wide-association-studies-and-statistical-big%C3%A2-data-and-computational-topics
#6
REVIEW
Hima Anbunathan, Anne M Bowcock
The investigation of biological systems involving all organs of the body including the skin is in era of big data. This requires heavy-duty computational tools, and novel statistical methods. Microarrays have allowed the interrogation of thousands of common genetic markers in thousands of individuals from the same population (termed genome wide association studies or GWAS) to reveal common variation associated with disease or phenotype. These markers are usually single nucleotide polymorphisms (SNPs) that are relatively common in the population...
May 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28410515/folate-receptor-targeted-hybrid-lipid-core-nanocapsules-for-sequential-delivery-of-doxorubicin-and-tanespimycin
#7
Biki Gupta, Shiva Pathak, Bijay Kumar Poudel, Shobha Regmi, Hima Bindu Ruttala, Milan Gautam, Jong Seong Lee, Jee-Heon Jeong, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
When exposed to cancer cells, cytotoxic drugs such as doxorubicin (DOX) can lead to the induction of heat shock protein 90 (Hsp90), a molecular chaperone associated with a number of cancer-related client proteins, and result in cell survival. Co-administration of DOX with tanespimycin (TNP), an Hsp90 inhibitor, can sensitize the cancer cells to the cytotoxic effects of DOX. The effect of such a combination has been found to depend on the schedule of administration. Sequential administration of DOX and TNP has been linked to highly synergistic combination effects...
April 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28403775/synthesis-and-bioevaluation-of-quaternary-centered-3-hydroxy-3-alkynyl-indolin-2-one-derivatives-as-potential-cytotoxic-agents-and-akt-kinase-inhibitors
#8
Sai Prathima Parvathaneni, Bikshapathi Raktani, Y Poornachandra, Hima Bindu Vittam, G Jagadeeshkumar, Jagadeesh Nanubolu, C Ganesh, Jayathirtha Rao Vaidya
An expeditious approach for direct alkynylation of isatins (ketones) has been developed using tetrabutylammonium fluoride (TBAF) as a catalyst in THF solvent at room temperature under metal-free conditions. Furthermore this method is an economically viable process that also compliments green aspects like being a ligand/metal free process under ambient conditions. This reaction tolerated a wide range of substrates with good to excellent yields (80-94%). All the 3-hydroxy-3-ethynylindolin-2-one derivatives were subjected for in vitro cytotoxic activity on five different cancer cell lines...
April 12, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28388280/duvelisib-a-phosphoinositide-3-kinase-%C3%AE-%C3%AE-inhibitor-for-chronic-lymphocytic-leukemia
#9
Hima V Vangapandu, Nitin Jain, Varsha Gandhi
Frontline chemotherapy is successful against chronic lymphocytic leukemia (CLL), but results in untoward toxicity. Further, prognostic factors, cytogenetic anomalies, and compensatory cellular signaling lead to therapy resistance or disease relapse. Therefore, for the past few years, development of targeted therapies is on the rise. PI3K is a major player in the B-cell receptor (BCR) signaling axis, which is critical for the survival and maintenance of B cells. Duvelisib, a PI3K δ/γ dual isoform specific inhibitor that induces apoptosis and reduces cytokine and chemokine levels in vitro, holds promise for CLL...
May 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28373037/rodent-borne-trypanosoma-from-cities-and-villages-of-niger-and-nigeria-a-special-role-for-the-invasive-genus-rattus
#10
C Tatard, M Garba, P Gauthier, K Hima, E Artige, D K H J Dossou, S Gagaré, G Genson, P Truc, G Dobigny
Although they are known to sometimes infect humans, atypical trypanosomes are very poorly documented, especially in Africa where one lethal case has yet been described. Here we conducted a survey of rodent-borne Trypanosoma in 19 towns and villages of Niger and Nigeria, with a special emphasis on Niamey, the capital city of Niger. The 1298 rodents that were captured yielded 189 qPCR-positive animals from 14 localities, thus corresponding to a 14.6% overall prevalence. Rats, especially black rats, displayed particularly elevated prevalence (27...
April 1, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28353686/genetic-structure-and-invasion-history-of-the-house-mouse-mus-musculus-domesticus-in-senegal-west-africa-a-legacy-of-colonial-and-contemporary-times
#11
C Lippens, A Estoup, M K Hima, A Loiseau, C Tatard, A Dalecky, K Bâ, M Kane, M Diallo, A Sow, Y Niang, S Piry, K Berthier, R Leblois, J-M Duplantier, C Brouat
Knowledge of the genetic make-up and demographic history of invasive populations is critical to understand invasion mechanisms. Commensal rodents are ideal models to study whether complex invasion histories are typical of introductions involving human activities. The house mouse Mus musculus domesticus is a major invasive synanthropic rodent originating from South-West Asia. It has been largely studied in Europe and on several remote islands, but the genetic structure and invasion history of this taxon have been little investigated in several continental areas, including West Africa...
March 29, 2017: Heredity
https://www.readbyqxmd.com/read/28274071/extra-nasopharyngeal-angiofibroma-simulating-a-mucocele-a-new-location-for-the-rare-entity
#12
Srikanth Goud, Tipirisety Swapna, Hima Bindu, Sanjeeva Reddy Gari Shylaja
Angiofibromas are rare, benign, but locally aggressive vascular tumours which account for 0.05-0.5% of all head and neck neoplasms. The common variant of angiofibromas of head and neck region is Juvenile Nasopharyngeal Angiofibroma (JNAF) which is well published in the literature. Incidence of Extranasopharygeal Angiofibromas (ENAF) is relatively rare and most of the published literature favours maxillary sinus as the most common site. We report a rare clinical entity of ENAF involving the upper lip which is first of its kind in the light of literature review owing to its anatomical location...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28259556/a-multi-country-study-to-assess-the-effect-of-a-treatment-with-moxidectin-pour-on-during-the-dry-period-on-milk-production-in-dairy-cows
#13
Thomas Geurden, David J Bartram, Hima Bindu Vanimisetti, Jane Fanke, Philippe Camuset, Jacques Devos, Andrew Sawyer, Georg von Samson-Himmelstjerna, Janina Demeler, Johannes Charlier
A randomized clinical study was conducted in a total of 45 commercial dairy farms in France (14 farms), Germany (28 farms) and the UK (3 farms) to evaluate the effect of an anthelmintic treatment on milk yield in the subsequent lactation. A total of 1287 animals with suspected exposure to Ostertagia ostertagi were included in the study. Animals were treated during the dry period (7-77days before parturition) with moxidectin pour-on (Cydectin(®) 0.5% Pour-On, Zoetis; 638 animals) or left untreated (649 animals) according to a randomized block design...
February 20, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28122339/molecularly-targeted-co-delivery-of-a-histone-deacetylase-inhibitor-and-paclitaxel-by-lipid-protein-hybrid-nanoparticles-for-synergistic-combinational-chemotherapy
#14
Hima Bindu Ruttala, Thiruganesh Ramasamy, Bijay Kumar Poudal, Yongjoo Choi, Ju Yeon Choi, Jeonghwan Kim, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
In this study, a transferrin-anchored albumin nanoplatform with PEGylated lipid bilayers (Tf-L-APVN) was developed for the targeted co-delivery of paclitaxel and vorinostat in solid tumors. Tf-L-APVN exhibited a sequential and controlled release profile of paclitaxel and vorinostat, with an accelerated release pattern at acidic pH. At cellular levels, Tf-L-APVN significantly enhanced the synergistic effects of paclitaxel and vorinostat on the proliferation of MCF-7, MDA-MB-231, and HepG2 cancer cells. Vorinostat could significantly enhance the cytotoxic potential of paclitaxel, induce marked cell apoptosis, alter cell cycle patterns, and inhibit the migratory capacity of cancer cells...
February 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28111215/noni-morinda-citrifolia-l-fruit-juice-reverses-age-related-decline-in-neural-immune-interactions-in-the-spleens-of-old-f344-rats
#15
Uday P Pratap, Lalgi Hima, Hannah P Priyanka, Srinivasan ThyagaRajan
ETHNOPHARMACOLOGICAL RELEVANCE: Various parts of the tropical plant, Morinda citrifolia L. (Noni), have been widely used in traditional medicine in South and Southeast Asia for several centuries. The therapeutic effects of the noni are believed to be mediated through several phytochemicals such as anthraquinones, iridoid, fatty acid glycosides, alcohols, etc. AIM OF THE STUDY: The aim of the study is to investigate the effects of Morinda citrifolia fruit juice (noni fruit juice; NFJ) on neural-immune interactions through the involvement of intracellular signaling pathways both in vitro and in vivo in the splenic lymphocytes of young and old male F344 rats...
January 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28069389/layer-by-layer-assembly-of-hierarchical-nanoarchitectures-to-enhance-the-systemic-performance-of-nanoparticle-albumin-bound-paclitaxel
#16
Hima Bindu Ruttala, Thiruganesh Ramasamy, Beom Soo Shin, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Although protein-bound paclitaxel (PTX, Abraxane(®)) has been established as a standard PTX-based therapy against multiple cancers, its clinical success is limited by unfavorable pharmacokinetics, suboptimal biodistribution, and acute toxicities. In the present study, we aimed to apply the principles of a layer-by-layer (LbL) technique to improve the poor colloidal stability and pharmacokinetic pattern of nanoparticle albumin-bound paclitaxel (nab-PTX). LbL-based nab-PTX was successfully fabricated by the alternate deposition of polyarginine (pARG) and poly(ethylene glycol)-block-poly (L-aspartic acid) (PEG-b-PLD) onto an albumin conjugate...
March 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28064078/novel-indolizino-8-7-b-indole-hybrids-as-anti-small-cell-lung-cancer-agents-regioselective-modulation-of-topoisomerase-ii-inhibitory-and-dna-crosslinking-activities
#17
Sue-Ming Chang, Wilson Christian, Ming-Hsi Wu, Tai-Lin Chen, Yi-Wen Lin, Ching-Shu Suen, Hima Bindu Pidugu, Dilip Detroja, Anamik Shah, Ming-Jing Hwang, Tsann-Long Su, Te-Chang Lee
A novel series of bis(hydroxymethyl)indolizino[8,7-b]indole hybrids composed of β-carboline (topoisomerase I/II inhibition) and bis(hydroxymethyl)pyrrole (DNA cross-linking) are synthesized for antitumor evaluation. Of tumor cell lines tested, small cell lung cancer (SCLC) cell lines are the most sensitive to the newly synthesized compounds. These hybrids induce cell cycle arrest at the G2/M phase, trigger tumor cell apoptotic death, and display diverse mechanisms of action involving topoisomerase II (Topo II) inhibition and induction of DNA cross-linking...
February 15, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27813088/nutlin-3a-selects-for-cells-harbouring-tp53-mutations
#18
Jill E Kucab, Monica Hollstein, Volker M Arlt, David H Phillips
TP53 mutations occur in half of all human tumours. Mutagen-induced or spontaneous TP53 mutagenesis can be studied in vitro using the human TP53 knock-in (Hupki) mouse embryo fibroblast (HUF) immortalisation assay (HIMA). TP53 mutations arise in up to 30% of mutagen-treated, immortalised HUFs; however, mutants are not identified until TP53 sequence analysis following immortalisation (2-5 months) and much effort is expended maintaining TP53-WT cultures. In order to improve the selectivity of the HIMA for HUFs harbouring TP53 mutations, we explored the use of Nutlin-3a, an MDM2 inhibitor that leads to stabilisation and activation of wild-type (WT) p53...
February 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27794477/engineering-of-cell-microenvironment-responsive-polypeptide-nanovehicle-co-encapsulating-a-synergistic-combination-of-small-molecules-for-effective-chemotherapy-in-solid-tumors
#19
Thiruganesh Ramasamy, Hima Bindu Ruttala, Nataraj Chitrapriya, Bijay Kumar Poudal, Ju Yeon Choi, Ssang Tae Kim, Yu Seok Youn, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
In this study, we report a facile method to construct a bioactive (poly(phenylalanine)-b-poly(l-histidine)-b-poly(ethylene glycol) polypeptide nanoconstruct to co-load doxorubicin (DOX) and quercetin (QUR) (DQ-NV). The smart pH-sensitive nanovehicle was fabricated with precisely tailored drug-to-carrier ratio that resulted in accelerated, sequential drug release. As a result of ratiometric loading, QUR could significantly enhance the cytotoxic potential of DOX, induced marked cell apoptosis; change cell cycle patterns, inhibit the migratory capacity of sensitive and resistant cancer cells...
October 26, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27734029/hepatoblastoma-modeling-in-mice-places-nrf2-within-a-cancer-field-established-by-mutant-%C3%AE-catenin
#20
Sarah A Comerford, Elizabeth A Hinnant, Yidong Chen, Hima Bansal, Shawn Klapproth, Dinesh Rakheja, Milton J Finegold, Dolores Lopez-Terrada, Kathryn A O'Donnell, Gail E Tomlinson, Robert E Hammer
Aberrant wnt/β-catenin signaling and amplification/overexpression of Myc are associated with hepatoblastoma (HB), the most prevalent type of childhood liver cancer. To address their roles in the pathogenesis of HB, we generated mice in which Myc and mutant β-catenin were targeted to immature cells of the developing mouse liver. Perinatal coexpression of both genes promoted the preferential development of HBs over other tumor types in neonatal mice, all of which bore striking resemblance to their human counterparts...
October 6, 2016: JCI Insight
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