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https://www.readbyqxmd.com/read/28932073/a-lagging-lock-hair-cycle-abnormalities-in-follicular-vitiligo
#1
Hima Gopinath, Kaliaperumal Karthikeyan, Meghana Valeti
No abstract text is available yet for this article.
July 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28921693/liquid-cell-electron-microscopy-of-adsorbed-polymers
#2
Kandula Hima Nagamanasa, Huan Wang, Steve Granick
Individual macromolecules of polystyrene sulfonate and poly(ethylene oxide) are visualized with nanometer resolution using transmission electron microscopy (TEM) imaging of aqueous solutions with and without added salt, trapped in liquid pockets between creased graphene sheets. Successful imaging with 0.3 s per frame is enabled by the sluggish mobility of the adsorbed molecules. This study finds, validating others, that an advantage of this graphene liquid-cell approach is apparently to retard sample degradation from incident electrons, in addition to minimizing background scattering because graphene windows are atomically thin...
September 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28893049/comparative-evaluation-of-the-efficacy-of-bioactive-ceramic-composite-granules-alone-and-in-combination-with-platelet-rich-fibrin-in-the-treatment-of-mandibular-class-ii-furcation-defects-a-clinical-and-radiographic-study
#3
Hima S Lohi, Dilip G Nayak, Ashita S Uppoor
INTRODUCTION: Predictable closure of furcation defects with bone grafts, Guided Tissue Regeneration (GTR) and a combination of the two has remained an elusive goal so far. Hence, evaluation of biomimetic agents as candidate technologies for periodontal regeneration merit due consideration. In this study, Choukroun's Platelet Rich Fibrin (PRF), a second generation platelet concentrate, is combined with bone graft to examine if the addition enhances the therapeutic potential of bone graft in the management of Class II furcation defects...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892895/effectivity-of-titanium-oxide-based-nano-particles-on-e-coli-from-clinical-samples
#4
Hima Bindu Mantravadi
INTRODUCTION: Nanoparticles composed of Titanium Oxide (TiO2) are non toxic, durable, stable and have a high refractive index with a lot of scope in biomedical applications. Due to their antibacterial effects, they can be applied to inanimate objects like glass, metal and even biomedical implants. AIM: This study was conducted to assess the antibacterial effect of Titanium Oxide (TiO2) alone or with Silver (Ag) as an additive on Escherichia coli. MATERIALS AND METHODS: Escherichia coli isolates (n=25) sensitive to most of the drugs including first generation cephalosporins, ampicillin and amoxycillin from various samples like pus, urine, sputum and blood were placed onto the glass slides containing TiO2 annealed at 200°C, 400°C, TiO2 with 0...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28891336/polyunsaturated-fatty-acid-based-targeted-nanotherapeutics-to-enhance-the-therapeutic-efficacy-of-docetaxel
#5
Thiruganesh Ramasamy, Pasupathi Sundaramoorthy, Hima Bindu Ruttala, Yongjoo Choi, Woo Hyun Shin, Jee-Heon Jeong, Sae Kwang Ku, Han-Gon Choi, Hwan Mook Kim, Chul Soon Yong, Jong Oh Kim
Since breast cancer is one of the most lethal malignancies, targeted strategies are urgently needed. In this study, we report the enhanced therapeutic efficacy of docetaxel (DTX) when combined with polyunsaturated fatty acids (PUFA) for effective treatment of multi-resistant breast cancers. Folic acid (FA)-conjugated PUFA-based lipid nanoparticles (FA-PLN/DTX) was developed. The physicochemical properties, in vitro uptake, in vitro cytotoxicity, and in vivo anticancer activity of FA-PLN/DTX were evaluated. FA-PLN/DTX could efficiently target and treat human breast tumor xenografts in vivo...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28890258/facile-construction-of-bioreducible-crosslinked-polypeptide-micelles-for-enhanced-cancer-combination-therapy
#6
Hima Bindu Ruttala, Natarajan Chitrapriya, Kaliappan Kaliraj, Thiruganesh Ramasamy, Woo Hyun Shin, Jee-Heon Jeong, Jae Ryong Kim, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
In this study, we developed pH and redox-responsive crosslinked polypeptide-based combination micelles for enhanced chemotherapeutic efficacy and minimized side effects. The stability and drug release properties of the polypeptide micelles were efficiency balanced by the corona-crosslinking of the triblock copolymer, poly(ethylene glycol)-b-poly(aspartic acid)-b-poly(tyrosine) (PEG-b-pAsp-b-pTyr) with coordinated redox and pH dual-sensitivity by introducing disulfide crosslinkages. Because of the crosslinking of the middle shell of the triblock polypeptide micelles, their robust structure was maintained in strong destabilization conditions and exhibited excellent stability...
September 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28883877/homocystinuria-with-cerebral-venous-sinus-thrombosis-excellent-recovery-with-intravenous-recombinant-tissue-plasminogen-activator
#7
Vykuntaraju K Gowda, Raghunath C Nanjundappa, Hima Pendharkar, Naveen Benakappa
Hyperhomocysteinemia can cause cerebral venous thrombosis. Recombinant tissue plasminogen activator is one of the treatment options for cerebral venous thrombosis in selected cases. We present here a 7-year-old boy with homocysteinuria with stroke. MRI of brain showed cerebral venous sinus thrombosis. We successfully treated with intravenous recombinant tissue plasminogen activator. He recovered completely without any complications. Recombinant tissue plasminogen activator can be considered one of the treatment options in cerebral venous thrombosis in homocystinura...
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/28879938/isoniazid-toxicity-presenting-as-bilateral-dentate-hyperintensities
#8
Aarthi Deepesh, Hima S Pendharkar
No abstract text is available yet for this article.
September 2017: Neurology India
https://www.readbyqxmd.com/read/28863345/the-stromal-microenvironment-modulates-mitochondrial-oxidative-phosphorylation-in-chronic-lymphocytic-leukemia-cells
#9
Hima V Vangapandu, Mary L Ayres, Christopher A Bristow, William G Wierda, Michael J Keating, Kumudha Balakrishnan, Christine M Stellrecht, Varsha Gandhi
Peripheral blood chronic lymphocytic leukemia (CLL) cells are replicationally quiescent mature B-cells. In short-term cultures, supporting stromal cells provide a survival advantage to CLL cells by inducing transcription and translation without promoting proliferation. We hypothesized that the stromal microenvironment augments malignant B cells' metabolism to enable the cells to cope with their energy demands for transcription and translation. We used extracellular flux analysis to assess the two major energy-generating pathways, mitochondrial oxidative phosphorylation (OxPhos) and glycolysis, in primary CLL cells in the presence of three different stromal cell lines...
August 29, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28835371/b-cell-receptor-signaling-regulates-metabolism-in-chronic-lymphocytic-leukemia
#10
Hima Vangapandu, Ondrej Havranek, Mary Ayres, Benny A Kaipparettu, Kumudha Balakrishnan, William Wierda, Michael J Keating, R Eric Davis, Christine M Stellrecht, Varsha Gandhi
Chronic lymphocytic leukemia (CLL) cells are quiescent but have active transcription and translation processes, suggesting that these lymphocytes are metabolically active. Based on this premise, the metabolic phenotype of CLL lymphocytes was investigated by evaluating the two intracellular ATP generating pathways. Metabolic flux was assessed by measuring glycolysis as extracellular acidification rate (ECAR) and mitochondrial oxidative phosphorylation as oxygen consumption rate (OCR) and then correlated with prognostic factors...
August 23, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28732901/multiple-polysaccharide-drug-complex-loaded-liposomes-a-unique-strategy-in-drug-loading-and-cancer-targeting
#11
Hima Bindu Ruttala, Thiruganesh Ramasamy, Biki Gupta, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
In the present study, a unique strategy was developed to develop nanocarriers containing multiple therapeutics with controlled release characteristics. In this study, we demonstrated the synthesis of dextran sulfate-doxorubicin (DS-DOX) and alginate-cisplatin (AL-CIS) polymer-drug complexes to produce a transferrin ligand-conjugated liposome. The targeted nanoparticles (TL-DDAC) were nano-sized and spherical. The targeted liposome exhibited a specific receptor-mediated endocytic uptake in cancer cells. The enhanced cellular uptake of TL-DDAC resulted in a significantly better anticancer effect in resistant and sensitive breast cancer cells compared to that of the free drugs...
October 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28675346/trigeminal-neuralgia-caused-by-a-new-variant-of-persistent-trigeminal-artery-associated-with-agenesis-of-internal-carotid-artery
#12
Gorky Medhi, Hima Pendharkar, Karel terBrugge, Chandrajit Prasad, Arun Kumar Gupta
We report a hitherto undescribed persistent carotid vertebral anastomosis associated with ipsilateral internal carotid artery agenesis and bilateral duplication of the intradural vertebral arteries. This rare anomaly was detected on MRI, supplemented by CT angiography while evaluating for cause trigeminal neuralgia in a 37-year-old woman. The aberrant vessel was seen to cause thinning and lateral displacement of the left trigeminal nerve on CISS 3D images. Also noted was a bilateral vertebral artery duplication of the PSA variant with the posterior inferior cerebellar artery arising from the medial limb of the duplication on the left...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28627294/polyphenolic-characterisation-and-bioactivity-of-an-oxalis-pes-caprae-l-leaf-extract
#13
Marisa C Gaspar, Diogo A Fonseca, Manuel J Antunes, Christian Frigerio, Nelson G M Gomes, M Vieira, Armanda E Santos, Maria T Cruz, Maria D Cotrim, Maria G Campos
The present work is focused on the characterisation of the polyphenolic content of an Oxalis pes-caprae L. leaf extract and on the evaluation of its bioactivity with particular interest on its vascular activity and antioxidant potential. The polyphenolic content was characterised by HPLC-DAD and LC-MS/MS. The vascular activity was evaluated according to the influence on the serotonergic and adrenergic systems of the human internal mammary artery (HIMA). Antioxidant and neuroprotective studies were also conducted...
June 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28596992/lip-prints-a-study-of-its-uniqueness-among-students-of-mediciti-medical-college
#14
Archana Alzapur, Rajani S Nagothu, Hima B Nalluri
BACKGROUND: "Cheiloscopy" is a technique that deals with lip prints. The pattern of fine creases on the lips are unique to the individual. They are similar to finger prints and useful in crime investigation. AIMS AND OBJECTIVES: To study the uniqueness, prevalence, and gender significance of lip print patterns in human subjects. MATERIALS AND METHODS: The study was conducted on 100 randomly selected male and female undergraduate medical students...
January 2017: Indian Journal of Clinical Anatomy and Physiology
https://www.readbyqxmd.com/read/28572652/pancreatic-carcinoma-diagnosed-by-peroral-pancreatoscopy-using-the-spyglass-system
#15
Sindhu Barola, Hima Tadimeti, Yen-I Chen, Saowanee Ngamruengphong, Mouen A Khashab, Anthony N Kalloo, Vivek Kumbhari
No abstract text is available yet for this article.
June 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28557364/supine-awake-oximetry-as-a-screening-tool-for-daytime-hypercapnia-in-super-obese-patients
#16
Yewon Chung, Frances Louise Garden, Adelle S Jee, Subash Srikantha, Saurabh Gupta, Peter Richard Buchanan, Peter Wallace Collett, Guy Barrington Marks, Hima Vedam
AIMS: To determine the validity of supine awake oximetry as a test for daytime hypercapnia and severe sleep disordered breathing in super-obese patients and to provide evidence to support its use as a screening tool for these disorders in this high-risk patient population. METHODS: Cross-sectional diagnostic test evaluation of super-obese adults (BMI >50 kg/m(2) ) presenting to Liverpool Hospital, Australia, between 2009 and 2015 for diagnostic polysomnography and arterial blood gas measurement...
May 30, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28503309/are-there-two-forms-of-isometric-muscle-action-results-of-the-experimental-study-support-a-distinction-between-a-holding-and-a-pushing-isometric-muscle-function
#17
Laura V Schaefer, Frank N Bittmann
BACKGROUND: In isometric muscle function, there are subjectively two different modes of performance: one can either hold isometrically - thus resist an impacting force - or push isometrically - therefore work against a stable resistance. The purpose of this study is to investigate whether or not two different isometric muscle actions - the holding vs. pushing one (HIMA vs PIMA) - can be distinguished by objective parameters. METHODS: Ten subjects performed two different measuring modes at 80% of MVC realized by a special pneumatic system...
2017: BMC Sports Science, Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28472638/smart-chemistry-based-nanosized-drug-delivery-systems-for-systemic-applications-a-comprehensive-review
#18
REVIEW
Thiruganesh Ramasamy, Hima Bindu Ruttala, Biki Gupta, Bijay Kumar Poudel, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
This review focuses on the smart chemistry that has been utilized in developing polymer-based drug delivery systems over the past 10years. We provide a comprehensive overview of the different functional moieties and reducible linkages exploited in these systems, and outline their design, synthesis, and application from a therapeutic efficacy viewpoint. Furthermore, we highlight the next generation nanomedicine strategies based on this novel chemistry.
July 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28444602/bioactive-guided-fractionation-of-diols-from-streptomyces-sp-msl
#19
Raja Hima Bindhu Madasu, Vijayalakshmi Muvva, Rajesh Kumar Munaganti, Kumar Reddy Dorigondla, Venkateswarlu Yenamandra
An actinomycete strain with a great potential to produce bioactive compounds isolated from a laterite soil was identified as Streptomyces sp. MSL based on 16S rDNA sequence analysis. Secondary metabolites produced by the strain in optimized nutrient broth were extracted and analyzed by chromatographic and spectroscopic techniques. Among the different fractions, four diols, viz., (1) (2R,3R)-2,3-Butanediol, (2) (2R,3S)-2,3-Butanediol, (3) 2,3-dimethyl-2,3-butanediol (Pinacol), and (4) (3R)-1,3-Butanediol exhibited good antimicrobial activity...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28440229/pigmented-fungiform-papillae-in-mother-and-daughter
#20
Hima Gopinath, Gatha M Upadya
No abstract text is available yet for this article.
July 2017: Indian Journal of Dermatology, Venereology and Leprology
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