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https://www.readbyqxmd.com/read/28122339/molecularly-targeted-co-delivery-of-a-histone-deacetylase-inhibitor-and-paclitaxel-by-lipid-protein-hybrid-nanoparticles-for-synergistic-combinational-chemotherapy
#1
Hima Bindu Ruttala, Thiruganesh Ramasamy, Bijay Kumar Poudal, Yongjoo Choi, Ju Yeon Choi, Jeonghwan Kim, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
In this study, a transferrin-anchored albumin nanoplatform with PEGylated lipid bilayers (Tf-L-APVN) was developed for the targeted co-delivery of paclitaxel and vorinostat in solid tumors. Tf-L-APVN exhibited a sequential and controlled release profile of paclitaxel and vorinostat, with an accelerated release pattern at acidic pH. At cellular levels, Tf-L-APVN significantly enhanced the synergistic effects of paclitaxel and vorinostat on the proliferation of MCF-7, MDA-MB-231, and HepG2 cancer cells. Vorinostat could significantly enhance the cytotoxic potential of paclitaxel, induce marked cell apoptosis, alter cell cycle patterns, and inhibit the migratory capacity of cancer cells...
January 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28111215/noni-morinda-citrifolia-l-fruit-juice-reverses-age-related-decline-in-neural-immune-interactions-in-the-spleens-of-old-f344-rats
#2
Uday P Pratap, Lalgi Hima, Hannah P Priyanka, Srinivasan ThyagaRajan
ETHNOPHARMACOLOGICAL RELEVANCE: Various parts of the tropical plant, Morinda citrifolia L. (Noni), have been widely used in traditional medicine in South and Southeast Asia for several centuries. The therapeutic effects of the noni are believed to be mediated through several phytochemicals such as anthraquinones, iridoid, fatty acid glycosides, alcohols, etc. AIM OF THE STUDY: The aim of the study is to investigate the effects of Morinda citrifolia fruit juice (noni fruit juice; NFJ) on neural-immune interactions through the involvement of intracellular signaling pathways both in vitro and in vivo in the splenic lymphocytes of young and old male F344 rats...
January 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28069389/layer-by-layer-assembly-of-hierarchical-nanoarchitectures-to-enhance-the-systemic-performance-of-nanoparticle-albumin-bound-paclitaxel
#3
Hima Bindu Ruttala, Thiruganesh Ramasamy, Beom Soo Shin, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Although protein-bound paclitaxel (PTX, Abraxane(®)) has been established as a standard PTX-based therapy against multiple cancers, its clinical success is limited by unfavorable pharmacokinetics, suboptimal biodistribution, and acute toxicities. In the present study, we aimed to apply the principles of a layer-by-layer (LbL) technique to improve the poor colloidal stability and pharmacokinetic pattern of nanoparticle albumin-bound paclitaxel (nab-PTX). LbL-based nab-PTX was successfully fabricated by the alternate deposition of polyarginine (pARG) and poly(ethylene glycol)-block-poly (L-aspartic acid) (PEG-b-PLD) onto an albumin conjugate...
January 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28064078/novel-indolizino-8-7-b-indole-hybrids-as-anti-small-cell-lung-cancer-agents-regioselective-modulation-of-topoisomerase-ii-inhibitory-and-dna-crosslinking-activities
#4
Sue-Ming Chang, Wilson Christian, Ming-Hsi Wu, Tai-Lin Chen, Yi-Wen Lin, Ching-Shu Suen, Hima Bindu Pidugu, Dilip Detroja, Anamik Shah, Ming-Jing Hwang, Tsann-Long Su, Te-Chang Lee
A novel series of bis(hydroxymethyl)indolizino[8,7-b]indole hybrids composed of β-carboline (topoisomerase I/II inhibition) and bis(hydroxymethyl)pyrrole (DNA cross-linking) are synthesized for antitumor evaluation. Of tumor cell lines tested, small cell lung cancer (SCLC) cell lines are the most sensitive to the newly synthesized compounds. These hybrids induce cell cycle arrest at the G2/M phase, trigger tumor cell apoptotic death, and display diverse mechanisms of action involving topoisomerase II (Topo II) inhibition and induction of DNA cross-linking...
February 15, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27813088/nutlin-3a-selects-for-cells-harbouring-tp53-mutations
#5
Jill E Kucab, Monica Hollstein, Volker M Arlt, David H Phillips
TP53 mutations occur in half of all human tumours. Mutagen-induced or spontaneous TP53 mutagenesis can be studied in vitro using the human TP53 knock-in (Hupki) mouse embryo fibroblast (HUF) immortalisation assay (HIMA). TP53 mutations arise in up to 30% of mutagen-treated, immortalised HUFs; however, mutants are not identified until TP53 sequence analysis following immortalisation (2-5 months) and much effort is expended maintaining TP53-WT cultures. In order to improve the selectivity of the HIMA for HUFs harbouring TP53 mutations, we explored the use of Nutlin-3a, an MDM2 inhibitor that leads to stabilisation and activation of wild-type (WT) p53...
February 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27794477/engineering-of-cell-microenvironment-responsive-polypeptide-nanovehicle-co-encapsulating-a-synergistic-combination-of-small-molecules-for-effective-chemotherapy-in-solid-tumors
#6
Thiruganesh Ramasamy, Hima Bindu Ruttala, Nataraj Chitrapriya, Bijay Kumar Poudal, Ju Yeon Choi, Ssang Tae Kim, Yu Seok Youn, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
: In this study, we report a facile method to construct a bioactive (poly(phenylalanine)-b-poly(l-histidine)-b-poly(ethylene glycol) polypeptide nanoconstruct to co-load doxorubicin (DOX) and quercetin (QUR) (DQ-NV). The smart pH-sensitive nanovehicle was fabricated with precisely tailored drug-to-carrier ratio that resulted in accelerated, sequential drug release. As a result of ratiometric loading, QUR could significantly enhance the cytotoxic potential of DOX, induced marked cell apoptosis; change cell cycle patterns, inhibit the migratory capacity of sensitive and resistant cancer cells...
October 26, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27734029/hepatoblastoma-modeling-in-mice-places-nrf2-within-a-cancer-field-established-by-mutant-%C3%AE-catenin
#7
Sarah A Comerford, Elizabeth A Hinnant, Yidong Chen, Hima Bansal, Shawn Klapproth, Dinesh Rakheja, Milton J Finegold, Dolores Lopez-Terrada, Kathryn A O'Donnell, Gail E Tomlinson, Robert E Hammer
Aberrant wnt/β-catenin signaling and amplification/overexpression of Myc are associated with hepatoblastoma (HB), the most prevalent type of childhood liver cancer. To address their roles in the pathogenesis of HB, we generated mice in which Myc and mutant β-catenin were targeted to immature cells of the developing mouse liver. Perinatal coexpression of both genes promoted the preferential development of HBs over other tumor types in neonatal mice, all of which bore striking resemblance to their human counterparts...
October 6, 2016: JCI Insight
https://www.readbyqxmd.com/read/27728380/acute-acalculous-cholecystitis-as-initial-manifestation-in-dengue-fever
#8
Hima Nandakumar
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27721636/polytherapy-and-drug-interactions-in-elderly
#9
Hima Bindu Gujjarlamudi
There is an increase in population of elderly above the age of 65. As age advances, more diseases develop resulting in use of more medications. Physiological changes, alterations in homeostatic regulation and diseases modify pharmacokinetics and drug response in older patients. The risk for drug interactions and drug-related problems increases along with multiple medications. Periodic evaluation of the patients' drug regimen is essential to minimize polytherapy. Clinicians must be alert to the use of herbal and dietary supplements as they are prone to drug-drug interactions...
July 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/27622157/dose-escalated-stereotactic-body-radiation-therapy-for-prostate-cancer-quality-of-life-comparison-of-two-prospective-trials
#10
Harvey C Quon, Hima Bindu Musunuru, Patrick Cheung, Geordi Pang, Alexandre Mamedov, Laura D'Alimonte, Andrea Deabreu, Liying Zhang, Andrew Loblaw
INTRODUCTION: The optimal prostate stereotactic body radiation therapy (SBRT) dose-fractionation scheme is controversial. This study compares long-term quality of life (QOL) from two prospective trials of prostate SBRT to investigate the effect of increasing dose (NCT01578902 and NCT01146340). MATERIAL AND METHODS: Patients with localized prostate cancer received SBRT 35 or 40 Gy delivered in five fractions, once per week. QOL was measured using the Expanded Prostate Cancer Index Composite at baseline and every 6 months...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27569437/active-surveillance-for-intermediate-risk-prostate-cancer-survival-outcomes-in-the-sunnybrook-experience
#11
Hima Bindu Musunuru, Toshihiro Yamamoto, Laurence Klotz, Gabriella Ghanem, Alexandre Mamedov, Peraka Sethukavalan, Vibhuti Jethava, Suneil Jain, Liying Zhang, Danny Vesprini, Andrew Loblaw
PURPOSE: To assess the applicability of active surveillance in patients with intermediate risk prostate cancer, we compared the survival outcomes of patients with low risk and intermediate risk disease. MATERIALS AND METHODS: Active surveillance was offered to all patients with low risk (cT1-T2b and Gleason score 6 and prostate specific antigen 10 ng/ml or less) and select intermediate risk disease (age greater than 70 years with cT2c or prostate specific antigen 15 ng/ml or less, or Gleason score 3+4 or less)...
August 26, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27524392/early-motor-repertoire-in-very-low-birth-weight-infants-in-india-is-associated-with-motor-development-at-one-year
#12
Lars Adde, Niranjan Thomas, Hima B John, Samuel Oommen, Randi Tynes Vågen, Toril Fjørtoft, Alexander Refsum Jensenius, Ragnhild Støen
BACKGROUND: Most studies on Prechtl's method of assessing General Movements (GMA) in young infants originate in Europe. AIM: To determine if motor behavior at an age of 3 months post term is associated with motor development at 12 months post age in VLBW infants in India. METHODS: 243 VLBW infants (135 boys, 108 girls; median gestational age 31wks, range 26-39wks) were video-recorded at a median age of 11wks post term (range 9-16wks). Certified and experienced observers assessed the videos by the "Assessment of Motor Repertoire - 2-5 Months"...
November 2016: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27479083/analysis-and-implementation-of-an-electronic-laboratory-notebook-in-a-biomedical-research-institute
#13
Santiago Guerrero, Gwendal Dujardin, Alejandro Cabrera-Andrade, César Paz-Y-Miño, Alberto Indacochea, Marta Inglés-Ferrándiz, Hima Priyanka Nadimpalli, Nicola Collu, Yann Dublanche, Ismael De Mingo, David Camargo
Electronic laboratory notebooks (ELNs) will probably replace paper laboratory notebooks (PLNs) in academic research due to their advantages in data recording, sharing and security. Despite several reports describing technical characteristics of ELNs and their advantages over PLNs, no study has directly tested ELN performance among researchers. In addition, the usage of tablet-based devices or wearable technology as ELN complements has never been explored in the field. To implement an ELN in our biomedical research institute, here we first present a technical comparison of six ELNs using 42 parameters...
2016: PloS One
https://www.readbyqxmd.com/read/27402150/high-prevalence-of-vitamin-d-deficiency-in-chronic-non-specific-musculoskeletal-pain
#14
Sundarachary Nagarjunakonda, Sridhar Amalakanti, Veeramma Uppala, Hima Bindu Bolla, Rajeswari Daggumati, Harish Lavu, Anil Kumar Devanaboina
No abstract text is available yet for this article.
July 12, 2016: Musculoskeletal Care
https://www.readbyqxmd.com/read/27386534/experimental-river-delta-size-set-by-multiple-floods-and-backwater-hydrodynamics
#15
Vamsi Ganti, Austin J Chadwick, Hima J Hassenruck-Gudipati, Brian M Fuller, Michael P Lamb
River deltas worldwide are currently under threat of drowning and destruction by sea-level rise, subsidence, and oceanic storms, highlighting the need to quantify their growth processes. Deltas are built through construction of sediment lobes, and emerging theories suggest that the size of delta lobes scales with backwater hydrodynamics, but these ideas are difficult to test on natural deltas that evolve slowly. We show results of the first laboratory delta built through successive deposition of lobes that maintain a constant size...
May 2016: Science Advances
https://www.readbyqxmd.com/read/27357171/estimating-and-testing-high-dimensional-mediation-effects-in-epigenetic-studies
#16
Haixiang Zhang, Yinan Zheng, Zhou Zhang, Tao Gao, Brian Joyce, Grace Yoon, Wei Zhang, Joel Schwartz, Allan Just, Elena Colicino, Pantel Vokonas, Lihui Zhao, Jinchi Lv, Andrea Baccarelli, Lifang Hou, Lei Liu
MOTIVATION: High-dimensional DNA methylation markers may mediate pathways linking environmental exposures with health outcomes. However, there is a lack of analytical methods to identify significant mediators for high-dimensional mediation analysis. RESULTS: Based on sure independent screening and minimax concave penalty techniques, we use a joint significance test for mediation effect. We demonstrate its practical performance using Monte Carlo simulation studies and apply this method to investigate the extent to which DNA methylation markers mediate the causal pathway from smoking to reduced lung function in the Normative Aging Study...
October 15, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27279298/metabolic-syndrome-in-androgenic-alopecia
#17
Hima Gopinath, Gatha M Upadya
BACKGROUND: Androgenic alopecia has been associated with an increased risk of coronary heart disease in various studies. The relationship between androgenic alopecia and metabolic syndrome, a known risk factor for atherosclerotic cardiovascular disease, is still poorly understood. AIM: To study the association between metabolic syndrome and early-onset androgenic alopecia. METHODS: A hospital-based analytical cross-sectional study was done on men in the age group of 18-55 years...
July 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/27274082/mobile-phones-and-seizures-drug-resistant-epilepsy-is-less-common-in-mobile-phone-using-patients
#18
Sundarachary Nagarjunakonda, Sridhar Amalakanti, Veeramma Uppala, Rama Krishna Gajula, Ramya Sree Tata, Hima Bindu Bolla, Lalitha Rajanala, Srinivasulu Athina, Rajeswari Daggumati, Harish Lavu, Anil Kumar Devanaboina
BACKGROUND: Epilepsy is a condition where patients have seizures due to abnormal nerve impulses in the brain. The effect of mobile phone radiation on patients with seizures is not known. OBJECTIVE: To compare the seizure profile of patients not using mobile phones with that of their peers using mobile phones. METHODS: In a retrospective cohort study performed at the neurology outpatient department of Guntur Medical College Hospital, Guntur, India from September 2014 to September 2015, we included 178 consecutive epileptic patients aged 16-65 years, who had had seizure disorder for 1 year or more...
January 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/27242078/estrogen-induced-neuroprotective-and-anti-inflammatory-effects-are-dependent-on-the-brain-areas-of-middle-aged-female-rats
#19
Uday P Pratap, Anushree Patil, Himanshu R Sharma, Lalgi Hima, Ramanathan Chockalingam, Murali M Hariharan, Sushrut Shitoot, Hannah P Priyanka, Srinivasan ThyagaRajan
BACKGROUND: Reproductive aging in females is characterized by fluctuations and precipitous decline in estrogen levels, which may lead to reduction in cognitive function and age-associated neurodegenerative disorders. The nature of estrogen-mediated neuronal plasticity is unknown during reproductive aging. We hypothesize that estrogen treatment of early middle-aged ovariectomized rats may exert specific effects in the brain by modulating signaling pathways regulating metabolic enzymes, inflammatory markers, antioxidant status, cholinergic function and survival signals...
June 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27152482/predictors-of-asthma-following-severe-respiratory-syncytial-virus-rsv-bronchiolitis-in-early-childhood
#20
Susan Lu, Tina V Hartert, Mark L Everard, Hilde Giezek, Linda Nelsen, Anish Mehta, Hima Patel, Barbara Knorr, Theodore F Reiss
BACKGROUND: We sought to identify predictors of asthma development following severe early childhood RSV bronchiolitis. Different definitions of asthma were also compared. METHODS: This longitudinal, observational study (N = 343) followed patients (<2 years old) from a placebo-controlled trial (N = 979) of montelukast after RSV bronchiolitis to identify clinical, demographic, or biochemical predictors of asthma, atopic disorders, and chronic asthma therapy use at 6 years of age (Clinical Trials Registry Number: NCT01140048)...
December 2016: Pediatric Pulmonology
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