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https://www.readbyqxmd.com/read/28449405/the-impact-of-lesion-location-on-dysphagia-incidence-pattern-and-complications-in-acute-stroke-part-2-oropharyngeal-residue-swallow-and-cough-response-and-pneumonia
#1
S Suntrup-Krueger, A Kemmling, T Warnecke, C Hamacher, S Oelenberg, T Niederstadt, W Heindel, H Wiendl, R Dziewas
BACKGROUND AND PURPOSE: Dysphagia is a well-known complication of acute stroke. Given the complexity of cerebral swallowing control it is still difficult to predict which patients are likely to develop swallowing dysfunction based on their neuroimaging. In Part 2 of a comprehensive voxel-based imaging study, whether the location of a stroke lesion can be correlated with further dysfunctional swallowing patterns, pulmonary protective reflexes and pneumonia was evaluated. METHODS: In all, 200 acute stroke cases were investigated applying flexible endoscopic evaluation of swallowing within 96 h from admission...
April 27, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28448683/magnetic-resonance-imaging-connectivity-for-the-prediction-of-seizure-outcome-in-temporal-lobe-epilepsy
#2
Victoria L Morgan, Dario J Englot, Baxter P Rogers, Bennett A Landman, Ahmet Cakir, Bassel W Abou-Khalil, Adam W Anderson
OBJECTIVE: Currently, approximately 60-70% of patients with unilateral temporal lobe epilepsy (TLE) remain seizure-free 3 years after surgery. The goal of this work was to develop a presurgical connectivity-based biomarker to identify those patients who will have an unfavorable seizure outcome 1-year postsurgery. METHODS: Resting-state functional and diffusion-weighted 3T magnetic resonance imaging (MRI) was acquired from 22 unilateral (15 right, 7 left) patients with TLE and 35 healthy controls...
April 27, 2017: Epilepsia
https://www.readbyqxmd.com/read/28448404/dynamic-contrast-enhanced-magnetic-resonance-imaging-of-ocular-melanoma-as-a-tool-to-predict-metastatic-potential
#3
Wenbo Wei, Guang Jia, Hendrik von Tengg-Kobligk, Johannes T Heverhagen, Mohamed Abdel-Rahman, Lai Wei, John B Christoforidis, Frederick Davidorf, Michael V Knopp
PURPOSE: This study explores the capability of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to differentiate tumor characteristics of metastatic and nonmetastatic choroidal melanoma as a potential tool for patient management. MATERIALS AND METHODS: A total of 13 patients (69 ± 9 years) with choroidal melanoma were imaged using DCE-MRI on a 3-T MRI system with a 16-channel head coil. The Tofts 2-compartment model was chosen for quantification, and parameters K (the transfer constant from the blood plasma to the extracellular space) and Kep (the transfer constant from the extracellular space to the blood plasma) were calculated and compared...
April 26, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28448310/comparison-of-power-versus-manual-injection-in-bolus-shape-and-image-quality-on-contrast-enhanced-magnetic-resonance-angiography-an-experimental-study-in-a-swine-model
#4
Takahiro Tsuboyama, Gregor Jost, Hubertus Pietsch, Noriyuki Tomiyama
OBJECTIVE: The aim of this study was to compare power versus manual injection in bolus shape and image quality on contrast-enhanced magnetic resonance angiography (CE-MRA). MATERIALS AND METHODS: Three types of CE-MRA (head-neck 3-dimensional [3D] MRA with a test-bolus technique, thoracic-abdominal 3D MRA with a bolus-tracking technique, and thoracic-abdominal time-resolved 4-dimensional [4D] MRA) were performed after power and manual injection of gadobutrol (0...
April 26, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28448270/a-new-in-vitro-spine-test-rig-to-track-multiple-vertebral-motions-under-physiological-conditions
#5
Agnes Beckmann, Christian Herren, Marion Mundt, Jan Siewe, Philipp Kobbe, Rolf Sobottke, Hans-Christoph Pape, Marcus Stoffel, Bernd Markert
In vitro pure moment spine tests are commonly used to analyse surgical implants in cadaveric models. Most of the tests are performed at room temperature. However, some new dynamic instrumentation devices and soft tissues show temperature-dependent material properties. Therefore, the aim of this study is to develop a new test rig, which allows applying pure moments on lumbar spine specimens in a vapour-filled chamber at body temperature. As no direct sight is given in the vapour-filled closed chamber, a magnetic tracking (MT) system with implantable receivers was used...
April 27, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28447995/rapid-and-refined-cd11b-magnetic-isolation-of-primary-microglia-with-enhanced-purity-and-versatility
#6
Souvarish Sarkar, Emir Malovic, Brandon Plante, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasamy
Microglia are the primary responders to central nervous system insults; however, much remains unknown about their role in regulating neuroinflammation. Microglia are mesodermal cells that function similarly to macrophages in surveying inflammatory stress. The classical (M1-type) and alternative (M2-type) activations of macrophages have also been extended to microglia in an effort to better understand the underlying interplay these phenotypes have in neuroinflammatory conditions such as Parkinson's, Alzheimer's, and Huntington's Diseases...
April 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447632/a-universal-model-for-solar-eruptions
#7
Peter F Wyper, Spiro K Antiochos, C Richard DeVore
Magnetically driven eruptions on the Sun, from stellar-scale coronal mass ejections to small-scale coronal X-ray and extreme-ultraviolet jets, have frequently been observed to involve the ejection of the highly stressed magnetic flux of a filament. Theoretically, these two phenomena have been thought to arise through very different mechanisms: coronal mass ejections from an ideal (non-dissipative) process, whereby the energy release does not require a change in the magnetic topology, as in the kink or torus instability; and coronal jets from a resistive process involving magnetic reconnection...
April 26, 2017: Nature
https://www.readbyqxmd.com/read/28447451/improvement-of-a-p450-based-recombinant-e-coli-whole-cell-system-for-the-production-of-oxygenated-sesquiterpene-derivatives
#8
Thuy Thi Bich Ly, Alexander Schifrin, Bach Duc Nguyen, Rita Bernhardt
Sesquiterpenes are common constituents of essential oil in plants. Their oxygenated derivatives often possess desirable flavor, fragrant and pharmaceutical properties. Recently, the CYP264B1-based recombinant E. coli whole-cell system has been constructed for the oxidation of sesquiterpenes. However, limiting factors of this system related to the high volatility of substrates and the suitability of the P450 redox partner need to be addressed. In this work, the improvement of the system was implemented with (+)-α-longipinene as a model substrate...
April 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28447284/apical-sparing-pattern-of-left-ventricular-myocardial-99m-tc-hmdp-uptake-in-patients-with-transthyretin-cardiac-amyloidosis
#9
Axel Van Der Gucht, Anne-Ségolène Cottereau, Mukedaisi Abulizi, Aziz Guellich, Paul Blanc-Durand, Jean-Marc Israel, Arnault Galat, Violaine Plante-Bordeneuve, Jean-Luc Dubois-Randé, Diane Bodez, Jean Rosso, Thibaud Damy, Emmanuel Itti
BACKGROUND: A decreased longitudinal strain in basal segments with a base-to-apex gradient has been described in patients with cardiac amyloidosis (CA). OBJECTIVES: Aim was to investigate the left ventricular (LV) regional distribution of early-phase (99m)Tc-Hydroxymethylene diphosphonate ((99m)Tc-HMDP) uptake in patients with transthyretin-related cardiac amyloidosis (TTR-CA). METHODS: All patients underwent a whole-body planar (99m)Tc-HMDP scintigraphy acquired at 10-min post-injection (early-phase) followed by a thorax SPECT/CT...
April 26, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28446949/reliability-of-motor-evoked-potentials-induced-by-transcranial-magnetic-stimulation-the-effects-of-initial-motor-evoked-potentials-removal
#10
Fahimeh Hashemirad, Maryam Zoghi, Paul B Fitzgerald, Shapour Jaberzadeh
INTRODUCTION: Transcranial magnetic stimulation (TMS) is a useful tool for assessment of corticospinal excitability (CSE) changes in both healthy individuals and patients with brain disorders. The usefulness of TMS-elicited motor evoked potentials (MEPs) for the assessment of CSE in a clinical context depends on their intra-and inter-session reliability. This study aimed to evaluate if removal of initial MEPs elicited by using two types of TMS techniques influences the reliability scores and whether this effect is different in blocks with variable number of MEPs...
January 2017: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/28446938/minimally-invasive-surgery-for-resection-of-ossification-of-the-ligamentum-flavum-in-the-thoracic-spine
#11
Wei Zhao, Chaoxiong Shen, Ranze Cai, Jianfeng Wu, Yuandong Zhuang, Zhaowen Cai, Rui Wang, Chunmei Chen
INTRODUCTION: Thoracic ossification of the ligamentum flavum (TOLF) is a common cause of progressive thoracic myelopathy. Surgical decompression is commonly used to treat TOLF. AIM: To evaluate the clinical outcomes of microsurgical decompression of TOLF via a paraspinal approach, using a percutaneous tubular retractor system. MATERIAL AND METHODS: First, three-dimensional (3D) image reconstruction and printed models were made from thin computed tomography scans for each patient...
2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/28446216/the-effect-of-adipose-tissue-derived-stem-cells-in-a-middle-cerebral-artery-occlusion-stroke-model-depends-on-their-engraftment-rate
#12
Saskia Grudzenski, Sebastian Baier, Anne Ebert, Pim Pullens, Andreas Lemke, Karen Bieback, Rick M Dijkhuizen, Lothar R Schad, Angelika Alonso, Michael G Hennerici, Marc Fatar
BACKGROUND: In the field of experimental stem cell therapy, intra-arterial (IA) delivery yields the best results concerning, for example, migrated cell number at the targeted site. However, IA application also appears to be associated with increased mortality rates and infarction. Since many rodent studies systemically apply 1 × 10(6) cells, this could also be a consequence of engrafted cell number. The aim of this study was therefore to investigate the effect of different doses of adipose tissue-derived stem cells (ASCs) on engraftment rates and stroke outcome measured in vivo using 9...
April 26, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28446207/memory-is-preserved-in-older-adults-taking-at1-receptor-blockers
#13
Jean K Ho, Daniel A Nation
BACKGROUND: Prior work suggests that some but not all antihypertensive treatments may benefit cognition and risk for Alzheimer's disease, independent of stroke. Angiotensin II receptor blockers (ARBs) have been highlighted as one antihypertensive drug class that may confer greatest benefit. METHODS: The participants comprised 1626 nondemented adults, aged 55-91 years, recruited from Alzheimer's Disease Neuroimaging Initiative sites. Three groups were compared: ARB users (HTN-ARBs), other antihypertensive drug users (HTN-Other), and normotensives...
April 26, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28446132/pcsk5-is-required-in-the-early-cranio-cardiac-mesoderm-for-heart-development
#14
Dorota Szumska, Milena Cioroch, Angela Keeling, Annik Prat, Nabil G Seidah, Shoumo Bhattacharya
BACKGROUND: Loss of proprotein convertase subtilisin/kexin type 5 (Pcsk5) results in multiple developmental anomalies including cardiac malformations, caudal regression, pre-sacral mass, renal agenesis, anteroposterior patterning defects, and tracheo-oesophageal and anorectal malformations, and is a model for VACTERL/caudal regression/Currarino syndromes (VACTERL association - Vertebral anomalies, Anal atresia, Cardiac defects, Tracheoesophageal fistula and/or Esophageal atresia, Renal & Radial anomalies and Limb defects)...
April 26, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/28445847/to-elute-or-not-to-elute-in-immunocapture-bottom-up-lc-ms
#15
Maren Christin Stillesby Levernæs, Marianne Nordlund Broughton, Léon Reubsaet, Trine Grønhaug Halvorsen
Immunocapture-based bottom-up LC-MS is a promising technique for the quantification of low abundant proteins. Magnetic immunocapture beads provide efficient enrichment from complex samples through the highly specific interaction between the target protein and its antibody. In this article, we have performed the first thorough comparison between digestion of proteins while bound to antibody coated beads versus after elution from the beads. Two previously validated immunocapture based MS methods for the quantification of pro-gastrin releasing peptide (ProGRP) and human chorionic gonadotropin (hCG) were used as model systems...
April 14, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28445310/diagnostic-accuracy-of-serum-alanine-aminotransferase-as-biomarker-for-nonalcoholic-fatty-liver-disease-and-insulin-resistance-in-healthy-subjects-using-3t-mr-spectroscopy
#16
Jose Luis Martin-Rodriguez, Jorge Gonzalez-Cantero, Alvaro Gonzalez-Cantero, Juan Pedro Arrebola, Jorge Luis Gonzalez-Calvin
Recognition of the close relationship of nonalcoholic fatty liver disease (NAFLD) with diabetes mellitus 2, obesity, metabolic syndrome, and cardiovascular disease has stimulated growing interest in NAFLD as a public health problem. Serum alanine aminotransferase (ALT) has been proposed as a marker of NAFLD, but levels are within the range currently considered "normal" in a large proportion of NAFLD subjects.The aim of the study was to determine the diagnostic accuracy of serum ALT for identifying individuals with NAFLD, using 3-Tesla (T) magnetic resonance spectroscopy (H-MRS)...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28444763/manganese-concentration-mapping-in-the-rat-brain-with-mri-pet-and-autoradiography
#17
Geoffrey J Topping, Andrew Yung, Paul Schaffer, Cornelia Hoehr, Rick Kornelsen, Piotr Kozlowski, Vesna Sossi
PURPOSE: Mn(2+) is used a contrast agent and marker for neuronal activity with magnetic resonance imaging (MRI) in rats and mice, but its accumulation is generally not assessed quantitatively. In this work, non-radioactive Mn and (52) Mn are injected simultaneously in rats, and imaged with MRI, positron emission tomography (PET) and autoradiography (AR). Mn distributions are compared between modalities, to assess the potential and limitations on quantification of Mn with MRI, and to investigate the potential of multimodal measurement of Mn accumulation...
April 26, 2017: Medical Physics
https://www.readbyqxmd.com/read/28444501/validation-of-numerical-simulation-methods-in-aortic-arch-using-4d-flow-mri
#18
Shohei Miyazaki, Keiichi Itatani, Toyoki Furusawa, Teruyasu Nishino, Masataka Sugiyama, Yasuo Takehara, Satoshi Yasukochi
Computational fluid dynamics (CFD) are the gold standard in studying blood flow dynamics. However, CFD results are dependent on the boundary conditions and the computation model. The purpose of this study was to validate CFD methods using comparison with actual measurements of the blood flow vector obtained with four-dimensional (4D) flow magnetic resonance imaging (MRI). 4D Flow MRI was performed on a healthy adult and a child with double-aortic arch. The aortic lumen was segmented to visualize the blood flow...
April 25, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28444321/evidence-of-altered-brain-responses-to-nicotine-in-an-animal-model-of-adhd
#19
Guillaume L Poirier, Wei Huang, Kelly Tam, Joseph R DiFranza, Jean A King
Introduction: Individuals with attention deficit/hyperactivity disorder (ADHD) are susceptible to earlier and more severe nicotine addiction. To shed light on the relationship between nicotine and ADHD, we examined nicotine's effects on functional brain networks in an animal model of ADHD. Methods: Awake magnetic resonance imaging was used to compare functional connectivity in adolescent (postnatal day 44±2) males of the Spontaneously Hypertensive Rat (SHR) strain and two control strains, Wistar Kyoto and Sprague Dawley (n = 16 each)...
April 22, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28443896/an-msn-peg-ip-drug-delivery-system-and-il13r%C3%AE-2-as-targeted-therapy-for-glioma
#20
Jinlong Shi, Shiqiang Hou, Jianfei Huang, Shanshan Wang, Wei Huan, Chuanjun Huang, Xiaojiang Liu, Rui Jiang, Wenbo Qian, Jingjing Lu, Xiubing Wang, Wei Shi, Rongqin Huang, Jian Chen
A combination of gene therapy and chemotherapy has recently received interest as a targeted therapy for glioma. A mesoporous silica nanoparticle (MSN)-based vehicle coated with IL13Rα2-targeted peptide (IP) using polyethylene glycol (PEG), MSN-PEG-IP (MPI), was constructed and confirmed as a potential glioma-targeted drug delivery system in vitro. In this work, tissue microarray (TMA) results revealed that IL13Rα2 was over-expressed in human glioma tissues and that high expression of IL13Rα2 in patients was associated with poor survival...
April 26, 2017: Nanoscale
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